메뉴 건너뛰기




Volumn 6, Issue 12, 2010, Pages 2363-2372

System-level strategies for studying the metabolism of Mycobacterium tuberculosis

Author keywords

[No Author keywords available]

Indexed keywords

TUBERCULOSTATIC AGENT;

EID: 78149422217     PISSN: 1742206X     EISSN: 17422051     Source Type: Journal    
DOI: 10.1039/c003757p     Document Type: Review
Times cited : (14)

References (50)
  • 2
    • 70349751621 scopus 로고    scopus 로고
    • System-level analysis of Salmonella metabolism during infection
    • D. Bumann System-level analysis of Salmonella metabolism during infection Curr. Opin. Microbiol. 2009 12 559 567
    • (2009) Curr. Opin. Microbiol. , vol.12 , pp. 559-567
    • Bumann, D.1
  • 3
    • 57549102595 scopus 로고    scopus 로고
    • Genome-scale models of bacterial metabolism: Reconstruction and applications
    • M. Durot P. Bourguignon V. Schachter Genome-scale models of bacterial metabolism: reconstruction and applications FEMS Microbiol. Rev. 2008 33 164 190
    • (2008) FEMS Microbiol. Rev. , vol.33 , pp. 164-190
    • Durot, M.1    Bourguignon, P.2    Schachter, V.3
  • 5
    • 35348934254 scopus 로고    scopus 로고
    • Genome-scale reconstruction of metabolic network in Bacillus subtilis based on high-throughput phenotyping and gene essentiality data
    • Y. K. Oh B. O. Palsson S. M. Park C. H. Schilling R. Mahadevan Genome-scale reconstruction of metabolic network in Bacillus subtilis based on high-throughput phenotyping and gene essentiality data J. Biol. Chem. 2007 282 28791 28799
    • (2007) J. Biol. Chem. , vol.282 , pp. 28791-28799
    • Oh, Y.K.1    Palsson, B.O.2    Park, S.M.3    Schilling, C.H.4    Mahadevan, R.5
  • 8
    • 45149111660 scopus 로고    scopus 로고
    • The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli
    • A. M. Feist B. O. Palsson The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli Nat. Biotechnol. 2008 26 659 667
    • (2008) Nat. Biotechnol. , vol.26 , pp. 659-667
    • Feist, A.M.1    Palsson, B.O.2
  • 9
    • 70350676551 scopus 로고    scopus 로고
    • A genome-scale metabolic model of Arabidopsis and some of its properties
    • M. G. Poolman L. Miguet L. J. Sweetlove D. A. Fell A genome-scale metabolic model of Arabidopsis and some of its properties Plant Physiol. 2009 151 1570 1581
    • (2009) Plant Physiol. , vol.151 , pp. 1570-1581
    • Poolman, M.G.1    Miguet, L.2    Sweetlove, L.J.3    Fell, D.A.4
  • 11
    • 67449096729 scopus 로고    scopus 로고
    • Flux balance analysis of biological systems: Applications and challenges
    • K. Raman N. Chandra Flux balance analysis of biological systems: applications and challenges Briefings Bioinf. 2009 10 435 440
    • (2009) Briefings Bioinf. , vol.10 , pp. 435-440
    • Raman, K.1    Chandra, N.2
  • 13
    • 34249934691 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for the production of l-valine based on transcriptome analysis and in silico gene knockout simulation
    • J. H. Park K. H. Lee T. Y. Kim S. Y. Lee Metabolic engineering of Escherichia coli for the production of l-valine based on transcriptome analysis and in silico gene knockout simulation Proc. Natl. Acad. Sci. U. S. A. 2007 104 7797 7802
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 7797-7802
    • Park, J.H.1    Lee, K.H.2    Kim, T.Y.3    Lee, S.Y.4
  • 14
    • 29144484729 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for enhanced production of succinic acid, based on genome comparison and in silico gene knockout simulation
    • S. J. Lee D. Y. Lee T. Y. Kim B. H. Kim J. Lee S. Y. Lee Metabolic engineering of Escherichia coli for enhanced production of succinic acid, based on genome comparison and in silico gene knockout simulation Appl. Environ. Microbiol. 2005 71 7880 7887
    • (2005) Appl. Environ. Microbiol. , vol.71 , pp. 7880-7887
    • Lee, S.J.1    Lee, D.Y.2    Kim, T.Y.3    Kim, B.H.4    Lee, J.5    Lee, S.Y.6
  • 16
    • 20944450448 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence
    • E. J. Munoz-Elias J. D. McKinney Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence Nat. Med. 2005 11 638 644
    • (2005) Nat. Med. , vol.11 , pp. 638-644
    • Munoz-Elias, E.J.1    McKinney, J.D.2
  • 17
    • 0033634971 scopus 로고    scopus 로고
    • A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis
    • M. S. Glickman J. S. Cox W. R. Jacobs A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis Mol. Cell 2000 5 717 727
    • (2000) Mol. Cell , vol.5 , pp. 717-727
    • Glickman, M.S.1    Cox, J.S.2    Jacobs, W.R.3
  • 18
    • 16244381720 scopus 로고    scopus 로고
    • The pyruvate requirement of some members of the Mycobacterium tuberculosis complex is due to an inactive pyruvate kinase: Implications for in vivo growth
    • L. A. Keating P. R. Wheeler H. Mansoor J. K. Inwald J. Dale R. G. Hewinson S. V. Gordon The pyruvate requirement of some members of the Mycobacterium tuberculosis complex is due to an inactive pyruvate kinase: implications for in vivo growth Mol. Microbiol. 2005 56 163 174
    • (2005) Mol. Microbiol. , vol.56 , pp. 163-174
    • Keating, L.A.1    Wheeler, P.R.2    Mansoor, H.3    Inwald, J.K.4    Dale, J.5    Hewinson, R.G.6    Gordon, S.V.7
  • 19
    • 33745235266 scopus 로고    scopus 로고
    • Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence
    • E. J. Munoz-Elias A. M. Upton J. Cherian J. D. McKinney Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence Mol. Microbiol. 2006 60 1109 1122
    • (2006) Mol. Microbiol. , vol.60 , pp. 1109-1122
    • Munoz-Elias, E.J.1    Upton, A.M.2    Cherian, J.3    McKinney, J.D.4
  • 20
    • 73549105511 scopus 로고    scopus 로고
    • An anaerobic-type α-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis
    • A. D. Baughn S. J. Garforth C. Vilchze W. R. Jacobs An anaerobic-type α-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis PLoS Pathog. 2009 5 e1000662
    • (2009) PLoS Pathog. , vol.5 , pp. 1000662
    • Baughn, A.D.1    Garforth, S.J.2    Vilchze, C.3    Jacobs, W.R.4
  • 21
    • 22644447865 scopus 로고    scopus 로고
    • Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: Identification of α-ketoglutarate decarboxylase
    • J. Tian R. Bryk M. Itoh M. Suematsu C. Nathan Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of α-ketoglutarate decarboxylase Proc. Natl. Acad. Sci. U. S. A. 2005 102 10670 10675
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 10670-10675
    • Tian, J.1    Bryk, R.2    Itoh, M.3    Suematsu, M.4    Nathan, C.5
  • 22
    • 14244250191 scopus 로고    scopus 로고
    • Compiling a molecular inventory for Mycobacterium bovis BCG at two growth rates: Evidence for growth rate-mediated regulation of ribosome biosynthesis and lipid metabolism
    • D. J. V. Beste J. Peters T. Hooper C. Avignone-Rossa M. E. Bushell J. McFadden Compiling a molecular inventory for Mycobacterium bovis BCG at two growth rates: evidence for growth rate-mediated regulation of ribosome biosynthesis and lipid metabolism J. Bacteriol. 2005 187 1677 1684
    • (2005) J. Bacteriol. , vol.187 , pp. 1677-1684
    • Beste, D.J.V.1    Peters, J.2    Hooper, T.3    Avignone-Rossa, C.4    Bushell, M.E.5    McFadden, J.6
  • 24
    • 84956662394 scopus 로고    scopus 로고
    • Carbon metabolism of enterobacterial human pathogens growing in epithelial colorectal adenocarcinoma (caco-2) cells
    • A. Gotz E. Eylert W. Eisenreich W. Goebel Carbon metabolism of enterobacterial human pathogens growing in epithelial colorectal adenocarcinoma (caco-2) cells PLoS One 2010 5 e10586
    • (2010) PLoS One , vol.5 , pp. 10586
    • Gotz, A.1    Eylert, E.2    Eisenreich, W.3    Goebel, W.4
  • 26
    • 33847654799 scopus 로고    scopus 로고
    • Flux balance analysis of mycolic acid pathway: Targets for anti-tubercular drugs
    • K. Raman P. Rajagopalan N. Chandra Flux balance analysis of mycolic acid pathway: targets for anti-tubercular drugs PLoS Comput. Biol. 2005 1 e46
    • (2005) PLoS Comput. Biol. , vol.1 , pp. 46
    • Raman, K.1    Rajagopalan, P.2    Chandra, N.3
  • 27
    • 34447523907 scopus 로고    scopus 로고
    • Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli
    • R. Schuetz L. Kuepfer U. Sauer Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli Mol. Syst. Biol. 2007 3 119
    • (2007) Mol. Syst. Biol. , vol.3 , pp. 119
    • Schuetz, R.1    Kuepfer, L.2    Sauer, U.3
  • 29
    • 34447317247 scopus 로고    scopus 로고
    • Investigating the metabolic capabilities of Mycobacterium tuberculosis H37rV using the in silico strain iNj661 and proposing alternative drug targets
    • N. Jamshidi B. O. Palsson Investigating the metabolic capabilities of Mycobacterium tuberculosis H37rV using the in silico strain iNj661 and proposing alternative drug targets BMC Syst. Biol. 2007 1 26
    • (2007) BMC Syst. Biol. , vol.1 , pp. 26
    • Jamshidi, N.1    Palsson, B.O.2
  • 30
    • 0345701347 scopus 로고    scopus 로고
    • Genes required for mycobacterial growth defined by high density mutagenesis
    • C. M. Sassetti D. H. Boyd E. J. Rubin Genes required for mycobacterial growth defined by high density mutagenesis Mol. Microbiol. 2003 48 77 84
    • (2003) Mol. Microbiol. , vol.48 , pp. 77-84
    • Sassetti, C.M.1    Boyd, D.H.2    Rubin, E.J.3
  • 31
    • 0034679958 scopus 로고    scopus 로고
    • Lipid lunch for persistent pathogen
    • W. Bishai Lipid lunch for persistent pathogen Nature 2000 406 683 685
    • (2000) Nature , vol.406 , pp. 683-685
    • Bishai, W.1
  • 32
    • 0347722525 scopus 로고    scopus 로고
    • TB drug discovery: Addressing issues of persistence and resistance
    • C. V. Smith V. Sharma J. C. Sacchettini TB drug discovery: addressing issues of persistence and resistance Tuberculosis 2004 84 45 55
    • (2004) Tuberculosis , vol.84 , pp. 45-55
    • Smith, C.V.1    Sharma, V.2    Sacchettini, J.C.3
  • 34
    • 14544268137 scopus 로고    scopus 로고
    • Uncovering transcriptional regulation of metabolism by using metabolic network topology
    • K. R. Patil J. Nielsen Uncovering transcriptional regulation of metabolism by using metabolic network topology Proc. Natl. Acad. Sci. U. S. A. 2005 102 2685 2689
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 2685-2689
    • Patil, K.R.1    Nielsen, J.2
  • 35
    • 78149439555 scopus 로고    scopus 로고
    • Differential producibility analysis (DPA) of transcriptomic data in the context of genome scale metabolic reaction networks: Deconstructing the metabolic response of M. tuberculosis to the host environment
    • B. K. Bonde D. J. V. Beste E. Laing A. M. Kierzek J. McFadden Differential producibility analysis (DPA) of transcriptomic data in the context of genome scale metabolic reaction networks: deconstructing the metabolic response of M. tuberculosis to the host environment PLoS Comput. Biol.
    • PLoS Comput. Biol.
    • Bonde, B.K.1    Beste, D.J.V.2    Laing, E.3    Kierzek, A.M.4    McFadden, J.5
  • 38
    • 63549148162 scopus 로고    scopus 로고
    • Genome-scale reconstruction of Escherichia coli's transcriptional and translational machinery: A knowledge base, its mathematical formulation, and its functional characterization
    • I. Thiele N. Jamshidi R. M. T. Fleming B. O. Palsson Genome-scale reconstruction of Escherichia coli's transcriptional and translational machinery: a knowledge base, its mathematical formulation, and its functional characterization PLoS Comput. Biol. 2009 5 e1000312
    • (2009) PLoS Comput. Biol. , vol.5 , pp. 1000312
    • Thiele, I.1    Jamshidi, N.2    Fleming, R.M.T.3    Palsson, B.O.4
  • 39
    • 73549086984 scopus 로고    scopus 로고
    • Computational systems approach for drug target discovery
    • N. Chandra Computational systems approach for drug target discovery Expert Opin. Drug Discovery 2009 4 1221 1236
    • (2009) Expert Opin. Drug Discovery , vol.4 , pp. 1221-1236
    • Chandra, N.1
  • 40
    • 62449223765 scopus 로고    scopus 로고
    • TargetTB: A target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis
    • K. Raman K. Yeturu N. Chandra TargetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis BMC Syst. Biol. 2008 2 109
    • (2008) BMC Syst. Biol. , vol.2 , pp. 109
    • Raman, K.1    Yeturu, K.2    Chandra, N.3
  • 41
    • 77049123018 scopus 로고    scopus 로고
    • Metabolite-centric approaches for the discovery of antibacterials using genome-scale metabolic networks
    • T. Y. Kim H. U. Kim S. Y. Lee Metabolite-centric approaches for the discovery of antibacterials using genome-scale metabolic networks Metab. Eng. 2010 12 105 111
    • (2010) Metab. Eng. , vol.12 , pp. 105-111
    • Kim, T.Y.1    Kim, H.U.2    Lee, S.Y.3
  • 43
    • 43749101877 scopus 로고    scopus 로고
    • The Mycobacterium tuberculosis Rv2540c dna sequence encodes a bifunctional chorismate synthase
    • F. Ely J. Nunes E. Schroeder J. Frazzon M. Palma D. Santos L. Basso The Mycobacterium tuberculosis Rv2540c dna sequence encodes a bifunctional chorismate synthase BMC Biochem. 2008 9 13
    • (2008) BMC Biochem. , vol.9 , pp. 13
    • Ely, F.1    Nunes, J.2    Schroeder, E.3    Frazzon, J.4    Palma, M.5    Santos, D.6    Basso, L.7
  • 44
    • 0036773752 scopus 로고    scopus 로고
    • The common aromatic amino acid biosynthesis pathway is essential in Mycobacterium tuberculosis
    • T. Parish N. G. Stoker The common aromatic amino acid biosynthesis pathway is essential in Mycobacterium tuberculosis Microbiology 2002 148 3069 3077
    • (2002) Microbiology , vol.148 , pp. 3069-3077
    • Parish, T.1    Stoker, N.G.2
  • 45
    • 72949105807 scopus 로고    scopus 로고
    • Strategies for efficient disruption of metabolism in Mycobacterium tuberculosis from network analysis
    • K. Raman R. Vashisht N. Chandra Strategies for efficient disruption of metabolism in Mycobacterium tuberculosis from network analysis Mol. BioSyst. 2009 5 1740 1751
    • (2009) Mol. BioSyst. , vol.5 , pp. 1740-1751
    • Raman, K.1    Vashisht, R.2    Chandra, N.3
  • 46
    • 70449513046 scopus 로고    scopus 로고
    • A systems biology framework for modeling metabolic enzyme inhibition of Mycobacterium tuberculosis
    • X. Fang A. Wallqvist J. Reifman A systems biology framework for modeling metabolic enzyme inhibition of Mycobacterium tuberculosis BMC Syst. Biol. 2009 3 92
    • (2009) BMC Syst. Biol. , vol.3 , pp. 92
    • Fang, X.1    Wallqvist, A.2    Reifman, J.3
  • 47
    • 73849090293 scopus 로고    scopus 로고
    • Accomplishments in genome-scale in silico modeling for industrial and medical biotechnology
    • C. B. Milne P.-J. Kim J. A. Eddy N. D. Price Accomplishments in genome-scale in silico modeling for industrial and medical biotechnology Biotechnol. J. 2009 4 1653 1670
    • (2009) Biotechnol. J. , vol.4 , pp. 1653-1670
    • Milne, C.B.1    Kim, P.-J.2    Eddy, J.A.3    Price, N.D.4
  • 48
    • 0344443759 scopus 로고    scopus 로고
    • A novel metabolic cycle catalyzes glucose oxidation and anaplerosis in hungry Escherichia coli
    • E. Fischer U. Sauer A novel metabolic cycle catalyzes glucose oxidation and anaplerosis in hungry Escherichia coli J. Biol. Chem. 2003 278 46446 46451
    • (2003) J. Biol. Chem. , vol.278 , pp. 46446-46451
    • Fischer, E.1    Sauer, U.2
  • 50
    • 34547888003 scopus 로고    scopus 로고
    • A genome-scale, constraint-based approach to systems biology of human metabolism
    • M. L. Mo N. Jamshidi B. O. Palsson A genome-scale, constraint-based approach to systems biology of human metabolism Mol. BioSyst. 2007 3 598 603
    • (2007) Mol. BioSyst. , vol.3 , pp. 598-603
    • Mo, M.L.1    Jamshidi, N.2    Palsson, B.O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.