Altered fatty acid metabolism due to rifampicin-resistance conferring mutations in the rpoB gene of mycobacterium tuberculosis: Mapping the potential of pharmaco-metabolomics for global health and personalized medicine

OMICS A Journal of Integrative Biology

Volumn 16, Issue 11, 2012, Pages 596-603

  Du Preez, Ilse ^a   Loots, Du Toit ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE LIPID; RIFAMPICIN; RNA POLYMERASE BETA SUBUNIT;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; GENE MUTATION; MASS FRAGMENTOGRAPHY; METABOLOMICS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PERSONALIZED MEDICINE; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL;

BACTERIAL PROTEINS; BIOSYNTHETIC PATHWAYS; DRUG RESISTANCE, BACTERIAL; FATTY ACIDS; HUMANS; INDIVIDUALIZED MEDICINE; METABOLOME; METABOLOMICS; MUTATION; MYCOBACTERIUM TUBERCULOSIS; RIFAMPIN;

MYCOBACTERIUM TUBERCULOSIS;

EID: 84868343034     PISSN: 15362310     EISSN: 15578100     Source Type: Journal    
DOI: 10.1089/omi.2012.0028     Document Type: Article

References (36)

1. Ahmad, S., Araj, G.F., Akbar, P.K., Fares, E., Chugh, T.D., and Mustafa, A.S. (2000). Characterization of rpoB mutations in rifampin-resistant Mycobacterium tuberculosis isolates from the Middle East. Diagn Microbiol Infect Dis 38, 227-232. (Pubitemid 32056227)
2. Anthony, R.M., Schuitema, A.R.J., Bergval, I.L., Brown, T.J., Oskam, L., and Klatser, P.R. (2005). Acquisition of rifabutin resistance by a rifampicin resistant mutant of Mycobacterium tuberculosis involves an unusual spectrum of mutations and elevated frequency. Ann Clin Microbiol Antimicrob 4, 9.
3. Aziz, M.A., Wright, A., Laszlo, A., et al. (2006). Epidemiology of antituberculosis drug resistance (the Global Project on Antituberculosis Drug Resistance Surveillance): an updated analysis. Lancet 368, 2142-2154. (Pubitemid 44914009)
4. Baran, R., Reindl, W., and Northen, T.R. (2009). Mass spectrometry based metabolomics and enzymatic assays for functional genomics. Curr Opin Microbiol 12, 547-552.
5. Barry, C.E. III, Lee, R.E., Mdluli, M., Sampson, A.E., Schroeder, B.G., Slayden, R.A., and Yuan, Y. (1998). Mycolic acids: structure, biosynthesis and physiological functions. Prog Lipid Res 37, 143-179. (Pubitemid 28391410)
6. Bergval, I.L., Klatser, P.R., Schuitema, A.R.J., Oskam, L., and Anthony, R.M. (2007). Specific mutations in the Mycobacterium tuberculosis rpoB gene are associated with increased dnaE2 expression. FEMS Microbiol Lett 275, 338-343. (Pubitemid 47437870)
7. Chatterjee, D. (1997). The mycobacterial cell wall: structure, biosynthesis and sites of drug action. Curr Opin Chem Biol 1, 579-568.
8. Chen, S. (2011). An "omics" approach to determine the mechanisms of acquired aromatase inhibitor resistance. OMICS 15, 347-352.
9. Debnath, M., Pandey, M., and Bisen, P.S. (2011). An omics approach to understand the plant abiotic stress. OMICS 15, 739-762.
10. De Carvalho, L.P.S., Fischer, S.M., Marrero, J., Nathan, C., Ehrt, S., and Rhee, L.Y. (2010). Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates. Chem Biol 17, 1122-1131.
11. Dunn, W.B., Bailey., N.J.C., and Johnson, H.E. (2005). Measuring the metabolome: current analytical technologies. Analyst 130, 606-625. (Pubitemid 40685888)
12. Dunn, W. Metabolite Identification in Metabolomics. (2012). Genet Eng Biotechn N Tutotrials 30, 8.
13. Fiehn, O., Kopka, J., Dörmann, P., Altmann, T., Trethewey, R.N., and Willmitzer, L. (2000). Metabolite profiling for plant functional genomics. Nature Biotechnol 18, 1157-1161.
14. Fulco, A.J., and Bloch, K. (1964). Cofactor requirements for the formation of D9-unsaturated fatty acids in Mycobacterium phlei. J Biol Chem 239, 993-997.
15. Gagneux, S., Long, C.D., Small, P.M., Van, T., Schoolnik, G.K., and Bohannan, B.J.M. (2006). The competitive cost of antibiotic resistance in Mycobacterium tuberculosis. Science 312, 1944-1946. (Pubitemid 43993719)
16. Garrett R.H., and Grisham, C.M. (2005). Biochemistry, 3rd ed. Belmont, CA: Thomas Brooks/Cole, 860-862.
17. Glickman, M.S., and Jacobs, W.R, Jr. (2001). Microbial pathogenesis of Mycobacterium tuberculosis: Dawn of a discipline. Cell 104, 477-485. (Pubitemid 32203703)
18. González, B., Pajares, M.A., Hermoso, J.A., Guillerm, D., Guillerm, G., and Sanz-Aparicio, J. (2003). Crystal structures of methionine adenosyltransferase complexed with substrates and products reveal the methionine-ATP recognition and give insights into the catalytic mechanism. J Mol Biol 331, 407-416. (Pubitemid 36904025)
19. Jain, M., Petzold, C.J., Schelle, M.W., et al. (2007). Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling. PNAS 104, 5133-5138. (Pubitemid 47186188)
20. Koekemoer, G., and Swanepoel, J.W.H. (2008). A semi-parametric method for transforming data to normality. Stat Comput 18, 241-257.
21. Kyoto Encyclopedia of Genes and Genomes (KEGG). (2011). http://www.genome.jp/kegg/pathway.
22. Madsen, R., Lundstedt, T., and Trygg, J. (2010). Chemometrics in metabolomics-A review in human disease diagnosis. Anal Chim Acta 659, 23-33.
23. Mariam, D.H., Mengistu, Y., Hoffner, S.E., and Andersson, D.I. (2004). Effect of rpoB mutations conferring rifampin resistance on fitness of Mycobacterium tuberculosis. Antimicrob Agents Chemother 48, 1289-1294. (Pubitemid 38405483)
24. McGaw, L.J., Lall, N., Meyer, J.J.M., and Eloff, J.N. (2008). The potential of South African plants against Mycobacterium infections. J Ethnopharmacol 119, 482-500.
25. Muñ oz-Eĺas, E.J., Upton, A.M., Cherian, J., and McKinney, J.D. (2006). Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence. Mol Microbiol 60, 1109-1122.
26. Nigou, J., Gilleron, M., and Puzo, G. (2003). Lipoarabinomannans: from structure to biosynthesis. Biochimie 85, 153-166. (Pubitemid 36625990)
27. Olivier, I., and Loots, D.T. (2012). A metabolomics approach to characterise and identify various Mycobacterium species. J Microbiol Methods 88, 419-426.
28. Olivier, I., and Loots, D.T. (2011). An overview of tuberculosis treatments and diagnostics. What role could metabolomics play? J Cell Tissue Res 11, 2655-2671.
29. Ramakrishnan, T., Murthy, P.S., and Gopinathan, K.P. (1972). Intermediary metabolism of mycobacteria. Bacteriol Rev 36, 65-108.
30. Rezwan, M., Lanéelle, M., Sander, P., and Daffé, M. (2007). Breaking down the wall: Fractionation of mycobacteria. J Microbiol Methods 68, 32-39. (Pubitemid 46054314)
31. Sandgren, A., Strong, M., Muthukrishnan, P., Weiner, B.K., Church, G.M., and Murray, M.B. (2009). Tuberculosis Drug Resistance Mutation Database. PLoS Med 6, e1000002. doi: 10.1371/journal.pmed.1000002
32. Schnackenberg, L.K., Jones, R.C., Thyparambil, S., et al. (2006). An integrated study of acute effects of valproic acid in the liver using metabonomics, proteomics, and transcriptomics platforms. OMICS 10, 1-14.
33. Shi, L., Sohaskey, C.D., Pfeiffer, C., et al. (2010). Carbon flux rerouting during Mycobacterium tuberculosis growth arrest. Mol Microbiol 78, 1199-1215.
34. Singh, J.A., Upshur, R., and Padayatchi, N. (2007). XDR-TB in South Africa: no time for denial or complacency. PLoS Med 4, 19-25.
35. Wehrli, W. (1983). Rifampin: Mechanisms of action and resistance. Rev Infect Dis 5, S407-S411.
36. World Health Organization. (2010). Multidrug and extensively drug-resistant TB (M/XDR-TB): 2010 global report on surveillance and response. Geneva, Switzerland.