Para-aminosalicylic acid is a prodrug targeting dihydrofolate reductase in mycobacterium tuberculosis

Journal of Biological Chemistry

Volumn 288, Issue 32, 2013, Pages 23447-23456

  Zheng, Jun ^a,g   Rubin, Eric J ^b   Bifani, Pablo ^a   Mathys, Vanessa ^c   Lim, Vivian ^a   Au, Melvin ^a   Jang, Jichan ^d   Nam, Jiyoun ^d   Dick, Thomas ^a,f   Walker, John R ^e   Pethe, Kevin ^d   Camacho, Luis R ^a  

^a NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c SCIENTIFIC INSTITUTE OF PUBLIC HEALTH   (Belgium)

^d Institute Pasteur Korea   (South Korea)

^e GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^f NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^g Vela Diagnostics Pte Ltd   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-MYCOBACTERIAL; ANTIBACTERIALS; BIOSYNTHETIC PATHWAY; DIHYDROFOLATE; DIHYDROFOLATE REDUCTASE; DRUG TARGETS; MYCOBACTERIUM TUBERCULOSIS; PRODRUGS;

BIOCHEMISTRY; BIOLOGY;

METABOLITES;

AMINOSALICYLIC ACID; ANTIMETABOLITE; BACTERIAL ENZYME; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; DIHYDROFOLATE SYNTHETASE; DIHYDROPTEROATE SYNTHASE; FOLIC ACID; FOLIC ACID DERIVATIVE; HYDROXYL DIHYDROFOLATE; PRODRUG; RIBOFLAVIN BIOSYNTHESIS PROTEIN; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; CONTROLLED STUDY; CROSS RESISTANCE; DRUG MECHANISM; DRUG TARGETING; ENZYME INHIBITION; ENZYME SUBSTRATE; FOLATE METABOLISM; GENE MUTATION; GENE OVEREXPRESSION; MOLECULAR RECOGNITION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; RIBD GENE;

ANTIBIOTIC ACTION; ANTIBIOTIC RESISTANCE; DRUG DEVELOPMENT; FOLATE METABOLISM; MICROBIOLOGY; MYCOBACTERIUM TUBERCULOSIS;

AMINOSALICYLIC ACID; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; DIHYDROPTEROATE SYNTHASE; FOLIC ACID ANTAGONISTS; GENE KNOCKDOWN TECHNIQUES; MUTATION; PRODRUGS; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 84881409003     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.475798     Document Type: Article

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