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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 17, 2013, Pages 4741-4750

A medicinal chemists' guide to the unique difficulties of lead optimization for tuberculosis

(2) Dartois, Véronique a Barry, Clifton E b

a PUBLIC HEALTH RESEARCH INSTITUTE (United States)

b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (United States)

Author keywords

Drug discovery; Tuberculosis

Indexed keywords

6,7 DIHYDRO 2 NITRO 6 (4 TRIFLUOROMETHOXYBENZYLOXY) 5H IMIDAZO[2,1 B][1,3]OXAZINE; BEDAQUILINE; CLOFAZIMINE; ETHAMBUTOL; ISONIAZID; MEFLOQUINE; MOXIFLOXACIN; PYRAZINAMIDE; RIFAMPICIN; STREPTOMYCIN;

ARTICLE; COMBINATION CHEMOTHERAPY; DRUG EFFICACY; DRUG PENETRATION; DRUG SENSITIVITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LUNG TUBERCULOSIS; MAXIMUM PLASMA CONCENTRATION; MICROENVIRONMENT; MINIMUM INHIBITORY CONCENTRATION; MONOTHERAPY; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; TREATMENT DURATION; VASCULARIZATION;

BACTERIA (MICROORGANISMS);

DRUG DISCOVERY; TUBERCULOSIS;

ANIMALS; ANTITUBERCULAR AGENTS; DRUG DISCOVERY; HUMANS; LUNG; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS;

EID: 84881367368 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.07.006 Document Type: Review

Times cited : (94)

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