Pathway-selective sensitization of mycobacterium tuberculosis for target-based whole-cell screening

Chemistry and Biology

Volumn 19, Issue 7, 2012, Pages 844-854

  Abrahams, Garth L ^a,b   Kumar, Anuradha ^c   Savvi, Suzana ^a   Hung, Alvin W ^d   Wen, Shijun ^d   Abell, Chris ^d   Barry III, Clifton E ^e   Sherman, David R ^c   Boshoff, Helena I M ^e   Mizrahi, Valerie ^a,b  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOCITRATE LYASE; PANTOTHENIC ACID;

ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BIOSYNTHESIS; CELL SCREENING; DRUG DEVELOPMENT; FEASIBILITY STUDY; GENE EXPRESSION; GENE SILENCING; HIGH THROUGHPUT SCREENING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHENOTYPE; PROMOTER REGION; SENSITIZATION; TARGET BASED WHOLE CELL SCREENING;

BACTERIAL PROTEINS; CARBOXY-LYASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; ISOCITRATE LYASE; MYCOBACTERIUM TUBERCULOSIS; PEPTIDE SYNTHASES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

MYCOBACTERIUM TUBERCULOSIS;

EID: 84864401215     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2012.05.020     Document Type: Article

References (39)

1. A. Blumenthal, C. Trujillo, S. Ehrt, and D. Schnappinger Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo PLoS One 5 2010 e15667
2. P. Carroll, M.C. Faray-Kele, and T. Parish Identifying vulnerable pathways in Mycobacterium tuberculosis by using a knockdown approach Appl. Environ. Microbiol. 77 2011 5040 5043
3. K. Chan, T. Knaak, L. Satkamp, O. Humbert, S. Falkow, and L. Ramakrishnan Complex pattern of Mycobacterium marinum gene expression during long-term granulomatous infection Proc. Natl. Acad. Sci. USA 99 2002 3920 3925
4. J.A. DeVito, J.A. Mills, V.G. Liu, A. Agarwal, C.F. Sizemore, Z. Yao, D.M. Stoughton, M.G. Cappiello, M.D. Barbosa, L.A. Foster, and D.L. Pompliano An array of target-specific screening strains for antibacterial discovery Nat. Biotechnol. 20 2002 478 483
5. S. Ehrt, X.V. Guo, C.M. Hickey, M. Ryou, M. Monteleone, L.W. Riley, and D. Schnappinger Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor Nucleic Acids Res. 33 2005 e21
6. R.A. Forsyth, R.J. Haselbeck, K.L. Ohlsen, R.T. Yamamoto, H. Xu, J.D. Trawick, D. Wall, L. Wang, V. Brown-Driver, and J.M. Froelich A genome-wide strategy for the identification of essential genes in Staphylococcus aureus Mol. Microbiol. 43 2002 1387 1400
7. S. Gandotra, D. Schnappinger, M. Monteleone, W. Hillen, and S. Ehrt In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice Nat. Med. 13 2007 1515 1520
8. P. Glaziou, K. Floyd, and M. Raviglione Global burden and epidemiology of tuberculosis Clin. Chest Med. 30 2009 621 636 vii
9. T.A. Gould, H. van de Langemheen, E.J. Muñoz-Elías, J.D. McKinney, and J.C. Sacchettini Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis Mol. Microbiol. 61 2006 940 947
10. X.V. Guo, M. Monteleone, M. Klotzsche, A. Kamionka, W. Hillen, M. Braunstein, S. Ehrt, and D. Schnappinger Silencing Mycobacterium smegmatis by using tetracycline repressors J. Bacteriol. 189 2007 4614 4623
11. S.M. Hingley-Wilson, V.K. Sambandamurthy, and W.R. Jacobs Jr. Survival perspectives from the world's most successful pathogen, Mycobacterium tuberculosis Nat. Immunol. 4 2003 949 955
12. K. Höner Zu Bentrup, A. Miczak, D.L. Swenson, and D.G. Russell Characterization of activity and expression of isocitrate lyase in Mycobacterium avium and Mycobacterium tuberculosis J. Bacteriol. 181 1999 7161 7167
13. A.W. Hung, H.L. Silvestre, S. Wen, A. Ciulli, T.L. Blundell, and C. Abell Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase Angew. Chem. Int. Ed. Engl. 48 2009 8452 8456
14. J. Inglese, D.S. Auld, A. Jadhav, R.L. Johnson, A. Simeonov, A. Yasgar, W. Zheng, and C.P. Austin Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries Proc. Natl. Acad. Sci. USA 103 2006 11473 11478
15. A. Koul, E. Arnoult, N. Lounis, J. Guillemont, and K. Andries The challenge of new drug discovery for tuberculosis Nature 469 2011 483 490
16. G. Lamichhane Novel targets in M. tuberculosis: search for new drugs Trends Mol. Med. 17 2010 25 33
17. J.D. McKinney, K. Höner zu Bentrup, E.J. Muñoz-Elías, A. Miczak, B. Chen, W.T. Chan, D. Swenson, J.C. Sacchettini, W.R. Jacobs Jr., and D.G. Russell Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase Nature 406 2000 735 738
18. K. Mdluli, and M. Spigelman Novel targets for tuberculosis drug discovery Curr. Opin. Pharmacol. 6 2006 459 467
19. C.D. Mitnick, B. McGee, and C.A. Peloquin Tuberculosis pharmacotherapy: strategies to optimize patient care Expert Opin. Pharmacother. 10 2009 381 401
20. E.J. Muñoz-Elías, and J.D. McKinney Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence Nat. Med. 11 2005 638 644
21. E.J. Muñoz-Elías, and J.D. McKinney Carbon metabolism of intracellular bacteria Cell. Microbiol. 8 2006 10 22
22. J. Ollinger, T. O'Malley, J. Ahn, J. Odingo, and T. Parish Inhibition of the sole type I signal peptidase of Mycobacterium tuberculosis is bactericidal under replicating and nonreplicating conditions J. Bacteriol. 194 2012 2614 2619
23. M.S. Pavelka Jr., and W.R. Jacobs Jr. Comparison of the construction of unmarked deletion mutations in Mycobacterium smegmatis, Mycobacterium bovis bacillus Calmette-Guérin, and Mycobacterium tuberculosis H37Rv by allelic exchange J. Bacteriol. 181 1999 4780 4789
24. M.S. Pavelka Jr., B. Chen, C.L. Kelley, F.M. Collins, and W.R. Jacobs Jr Jr. Vaccine efficacy of a lysine auxotroph of Mycobacterium tuberculosis Infect. Immun. 71 2003 4190 4192
25. D.J. Payne, M.N. Gwynn, D.J. Holmes, and D.L. Pompliano Drugs for bad bugs: confronting the challenges of antibacterial discovery Nat. Rev. Drug Discov. 6 2007 29 40
26. T.T. Pham, D. Jacobs-Sera, M.L. Pedulla, R.W. Hendrix, and G.F. Hatfull Comparative genomic analysis of mycobacteriophage Tweety: evolutionary insights and construction of compatible site-specific integration vectors for mycobacteria Microbiology 153 2007 2711 2723
27. V.K. Sambandamurthy, X. Wang, B. Chen, R.G. Russell, S. Derrick, F.M. Collins, S.L. Morris, and W.R. Jacobs Jr. A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis Nat. Med. 8 2002 1171 1174
28. C.M. Sassetti, D.H. Boyd, and E.J. Rubin Genes required for mycobacterial growth defined by high density mutagenesis Mol. Microbiol. 48 2003 77 84
29. S.B. Singh, J.W. Phillips, and J. Wang Highly sensitive target-based whole-cell antibacterial discovery strategy by antisense RNA silencing Curr. Opin. Drug Discov. Devel. 10 2007 160 166
30. A.M. Upton, and J.D. McKinney Role of the methylcitrate cycle in propionate metabolism and detoxification in Mycobacterium smegmatis Microbiology 153 2007 3973 3982
31. J. Wang, S.M. Soisson, K. Young, W. Shoop, S. Kodali, A. Galgoci, R. Painter, G. Parthasarathy, Y.S. Tang, and R. Cummings Platensimycin is a selective FabF inhibitor with potent antibiotic properties Nature 441 2006 358 361
32. M.E. Webb, A.G. Smith, and C. Abell Biosynthesis of pantothenate Nat. Prod. Rep. 21 2004 695 721
33. J.R. Wei, V. Krishnamoorthy, K. Murphy, J.H. Kim, D. Schnappinger, T. Alber, C.M. Sassetti, K.Y. Rhee, and E.J. Rubin Depletion of antibiotic targets has widely varying effects on growth Proc. Natl. Acad. Sci. USA 108 2011 4176 4181
34. S. Woong Park, M. Klotzsche, D.J. Wilson, H.I. Boshoff, H. Eoh, U. Manjunatha, A. Blumenthal, K. Rhee, C.E. Barry 3rd, and C.C. Aldrich Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression PLoS Pathog. 7 2011 e1002264
35. D.M. Yajko, J.J. Madej, M.V. Lancaster, C.A. Sanders, V.L. Cawthon, B. Gee, A. Babst, and W.K. Hadley Colorimetric method for determining MICs of antimicrobial agents for Mycobacterium tuberculosis J. Clin. Microbiol. 33 1995 2324 2327
36. K. Young, H. Jayasuriya, J.G. Ondeyka, K. Herath, C. Zhang, S. Kodali, A. Galgoci, R. Painter, V. Brown-Driver, and R. Yamamoto Discovery of FabH/FabF inhibitors from natural products Antimicrob. Agents Chemother. 50 2006 519 526
37. Y. Zhang The magic bullets and tuberculosis drug targets Annu. Rev. Pharmacol. Toxicol. 45 2005 529 564
38. Y. Zhang, and W.W. Yew Mechanisms of drug resistance in Mycobacterium tuberculosis Int. J. Tuberc. Lung Dis. 13 2009 1320 1330
39. R. Zheng, and J.S. Blanchard Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase Biochemistry 40 2001 12904 12912