메뉴 건너뛰기




Volumn 9, Issue FEB, 2015, Pages

Targeted pharmacological treatment of autism spectrum disorders: Fragile X and Rett syndromes

Author keywords

Autism spectrum disorders; FMRP; Fragile X syndrome; MeCP2; Pharmacotherapy; Rett syndrome; Synaptic deficits; Treatment

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; 6 QUINOXALINECARBOXYLIC ACID PIPERIDIDE; ACAMPROSATE; AMPA RECEPTOR; ARBACLOFEN; BASIMGLURANT; BRAIN DERIVED NEUROTROPHIC FACTOR; CANNABINOID RECEPTOR; DOPAMINE RECEPTOR; FENOBAM; GANAXOLONE; GLYCOGEN SYNTHASE KINASE 3; ION CHANNEL; LITHIUM; MAMMALIAN TARGET OF RAPAMYCIN; MAVOGLURANT; MEMANTINE; METABOTROPIC RECEPTOR; MEVINOLIN; MINOCYCLINE; MITOGEN ACTIVATED PROTEIN KINASE; MONOAMINE; MUSCARINIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OXYTOCIN; OXYTOCIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; SEROTONIN RECEPTOR; SOMATOMEDIN; UNCLASSIFIED DRUG;

EID: 84925070978     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2015.00055     Document Type: Article
Times cited : (26)

References (322)
  • 1
    • 78149259999 scopus 로고    scopus 로고
    • Correction of respiratory disorders in a mouse model of Rett syndrome
    • Abdala, A. P., Dutschmann, M., Bissonnette, J. M., and Paton, J. F. (2010). Correction of respiratory disorders in a mouse model of Rett syndrome. Proc. Natl. Acad. Sci. U S A 107, 18208-18213. doi: 10.1073/pnas.1012104107.
    • (2010) Proc. Natl. Acad. Sci. U S A , vol.107 , pp. 18208-18213
    • Abdala, A.P.1    Dutschmann, M.2    Bissonnette, J.M.3    Paton, J.F.4
  • 2
    • 84901806718 scopus 로고    scopus 로고
    • Effect of Sarizotan, a 5-HT1a and D2-like receptor agonist, on respiration in three mouse models of Rett syndrome
    • Abdala, A. P., Lioy, D. T., Garg, S. K., Knopp, S. J., Paton, J. F., and Bissonnette, J. M. (2014). Effect of Sarizotan, a 5-HT1a and D2-like receptor agonist, on respiration in three mouse models of Rett syndrome. Am. J. Respir. Cell Mol. Biol. 50, 1031-1039. doi: 10.1165/rcmb.2013-0372OC.
    • (2014) Am. J. Respir. Cell Mol. Biol. , vol.50 , pp. 1031-1039
    • Abdala, A.P.1    Lioy, D.T.2    Garg, S.K.3    Knopp, S.J.4    Paton, J.F.5    Bissonnette, J.M.6
  • 3
    • 84897088758 scopus 로고    scopus 로고
    • CYFIP family proteins between autism and intellectual disability: Links with Fragile X syndrome
    • Abekhoukh, S., and Bardoni, B. (2014). CYFIP family proteins between autism and intellectual disability: links with Fragile X syndrome. Front. Cell. Neurosci. 8:81. doi: 10.3389/fncel.2014.00081.
    • (2014) Front. Cell. Neurosci. , vol.8 , pp. 81
    • Abekhoukh, S.1    Bardoni, B.2
  • 4
    • 0032830639 scopus 로고    scopus 로고
    • Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
    • Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., and Zoghbi, H. Y. (1999). Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat. Genet. 23, 185-188. doi: 10.1038/13810.
    • (1999) Nat. Genet. , vol.23 , pp. 185-188
    • Amir, R.E.1    Van den Veyver, I.B.2    Wan, M.3    Tran, C.Q.4    Francke, U.5    Zoghbi, H.Y.6
  • 5
    • 84868628418 scopus 로고    scopus 로고
    • Translational medicine: Mice and men show the way
    • Anagnostou, E. (2012). Translational medicine: mice and men show the way. Nature 491, 196-197. doi: 10.1038/491196a.
    • (2012) Nature , vol.491 , pp. 196-197
    • Anagnostou, E.1
  • 6
    • 84907681050 scopus 로고    scopus 로고
    • Intranasal oxytocin in the treatment of autism spectrum disorders: A review of literature and early safety and efficacy data in youth
    • Anagnostou, E., Soorya, L., Brian, J., Dupuis, A., Mankad, D., Smile, S., et al. (2014a). Intranasal oxytocin in the treatment of autism spectrum disorders: a review of literature and early safety and efficacy data in youth. Brain Res. 1580, 188-198. doi: 10.1016/j.brainres.2014.01.049..
    • (2014) Brain Res. , vol.1580 , pp. 188-198
    • Anagnostou, E.1    Soorya, L.2    Brian, J.3    Dupuis, A.4    Mankad, D.5    Smile, S.6
  • 8
    • 77749292152 scopus 로고    scopus 로고
    • Promoting social behavior with oxytocin in high-functioning autism spectrum disorders
    • Andari, E., Duhamel, J. R., Zalla, T., Herbrecht, E., Leboyer, M., and Sirigu, A. (2010). Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Proc. Natl. Acad. Sci. U S A 107, 4389-4394. doi: 10.1073/pnas.0910249107.
    • (2010) Proc. Natl. Acad. Sci. U S A , vol.107 , pp. 4389-4394
    • Andari, E.1    Duhamel, J.R.2    Zalla, T.3    Herbrecht, E.4    Leboyer, M.5    Sirigu, A.6
  • 9
    • 82555196668 scopus 로고    scopus 로고
    • Mutations causing syndromic autism define an axis of synaptic pathophysiology
    • Auerbach, B. D., Osterweil, E. K., and Bear, M. F. (2011). Mutations causing syndromic autism define an axis of synaptic pathophysiology. Nature 480, 63-68. doi: 10.1038/nature10658.
    • (2011) Nature , vol.480 , pp. 63-68
    • Auerbach, B.D.1    Osterweil, E.K.2    Bear, M.F.3
  • 10
    • 85027958764 scopus 로고    scopus 로고
    • MeCP2: The long trip from a chromatin protein to neurological disorders
    • Ausió, J., de Paz, A. M., and Esteller, M. (2014). MeCP2: the long trip from a chromatin protein to neurological disorders. Trends Mol. Med. 20, 487-498. doi: 10.1016/j.molmed.2014.03.004.
    • (2014) Trends Mol. Med. , vol.20 , pp. 487-498
    • Ausió, J.1    de Paz, A.M.2    Esteller, M.3
  • 11
    • 84905825592 scopus 로고    scopus 로고
    • Genetic aspects of autism spectrum disorders: Insights from animal models
    • Banerjee, S., Riordan, M., and Bhat, M. A. (2014). Genetic aspects of autism spectrum disorders: insights from animal models. Front. Cell. Neurosci. 8:58. doi: 10.3389/fncel.2014.00058.
    • (2014) Front. Cell. Neurosci. , vol.8 , pp. 58
    • Banerjee, S.1    Riordan, M.2    Bhat, M.A.3
  • 12
    • 53849110899 scopus 로고    scopus 로고
    • Fragile X syndrome: Loss of local mRNA regulation alters synaptic development and function
    • Bassell, G. J., and Warren, S. T. (2008). Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function. Neuron 60, 201-214. doi: 10.1016/j.neuron.2008.10.004.
    • (2008) Neuron , vol.60 , pp. 201-214
    • Bassell, G.J.1    Warren, S.T.2
  • 13
    • 3042647610 scopus 로고    scopus 로고
    • The mGluR theory of fragile X mental retardation
    • Bear, M. F., Huber, K. M., and Warren, S. T. (2004). The mGluR theory of fragile X mental retardation. Trends Neurosci. 27, 370-377. doi: 10.1016/j.tins.2004.04.009.
    • (2004) Trends Neurosci. , vol.27 , pp. 370-377
    • Bear, M.F.1    Huber, K.M.2    Warren, S.T.3
  • 14
    • 84866681617 scopus 로고    scopus 로고
    • The GABA excitatory/inhibitory shift in brain maturation and neurological disorders
    • Ben-Ari, Y., Khalilov, I., Kahle, K. T., and Cherubini, E. (2012). The GABA excitatory/inhibitory shift in brain maturation and neurological disorders. Neuroscientist 18, 467-486. doi: 10.1177/1073858412438697.
    • (2012) Neuroscientist , vol.18 , pp. 467-486
    • Ben-Ari, Y.1    Khalilov, I.2    Kahle, K.T.3    Cherubini, E.4
  • 15
    • 84896400422 scopus 로고    scopus 로고
    • Mechanism-based treatments in neurodevelopmental disorders: Fragile X syndrome
    • Berry-Kravis, E. (2014). Mechanism-based treatments in neurodevelopmental disorders: fragile X syndrome.Pediatr. Neurol. 50, 297-302. doi: 10.1016/j.pediatrneurol.2013.12.001.
    • (2014) Pediatr. Neurol. , vol.50 , pp. 297-302
    • Berry-Kravis, E.1
  • 17
    • 65949096495 scopus 로고    scopus 로고
    • A pilot open label, single dose trial of fenobam in adults with fragile X syndrome
    • Berry-Kravis, E., Hessl, D., Coffey, S., Hervey, C., Schneider, A., Yuhas, J., et al. (2009). A pilot open label, single dose trial of fenobam in adults with fragile X syndrome. J. Med. Genet. 46, 266-271. doi: 10.1136/jmg.2008.063701.
    • (2009) J. Med. Genet. , vol.46 , pp. 266-271
    • Berry-Kravis, E.1    Hessl, D.2    Coffey, S.3    Hervey, C.4    Schneider, A.5    Yuhas, J.6
  • 18
    • 84866628742 scopus 로고    scopus 로고
    • Effects of STX209 (arbaclofen) on neurobehavioral function in children and adults with fragile X syndrome: A randomized, controlled, phase 2 trial
    • Berry-Kravis, E. M., Hessl, D., Rathmell, B., Zarevics, P., Cherubini, M., Walton-Bowen, K., et al. (2012). Effects of STX209 (arbaclofen) on neurobehavioral function in children and adults with fragile X syndrome: a randomized, controlled, phase 2 trial. Sci. Transl. Med. 4:152ra127. doi: 10.1126/scitranslmed.3004214.
    • (2012) Sci. Transl. Med. , vol.4
    • Berry-Kravis, E.M.1    Hessl, D.2    Rathmell, B.3    Zarevics, P.4    Cherubini, M.5    Walton-Bowen, K.6
  • 19
    • 80052347724 scopus 로고    scopus 로고
    • Targeted treatments for fragile X syndrome
    • Berry-Kravis, E., Knox, A., and Hervey, C. (2011). Targeted treatments for fragile X syndrome. J. Neurodev. Disord.3, 193-210. doi: 10.1007/s11689-011-9074-7.
    • (2011) J. Neurodev. Disord. , vol.3 , pp. 193-210
    • Berry-Kravis, E.1    Knox, A.2    Hervey, C.3
  • 20
    • 33750962399 scopus 로고    scopus 로고
    • Effect of CX516, an AMPA-modulating compound, on cognition and behavior in fragile X syndrome: A controlled trial
    • Berry-Kravis, E., Krause, S. E., Block, S. S., Guter, S., Wuu, J., Leurgans, S., et al. (2006). Effect of CX516, an AMPA-modulating compound, on cognition and behavior in fragile X syndrome: a controlled trial. J. Child Adolesc. Psychopharmacol. 16, 525-540. doi: 10.1089/cap.2006.16.525.
    • (2006) J. Child Adolesc. Psychopharmacol. , vol.16 , pp. 525-540
    • Berry-Kravis, E.1    Krause, S.E.2    Block, S.S.3    Guter, S.4    Wuu, J.5    Leurgans, S.6
  • 21
    • 51249098804 scopus 로고    scopus 로고
    • Open-label treatment trial of lithium to target the underlying defect in fragile X syndrome
    • Berry-Kravis, E., Sumis, A., Hervey, C., Nelson, M., Porges, S. W., Weng, N., et al. (2008). Open-label treatment trial of lithium to target the underlying defect in fragile X syndrome. J. Dev. Behav. Pediatr. 29, 293-302. doi: 10.1097/DBP.0b013e31817dc447.
    • (2008) J. Dev. Behav. Pediatr. , vol.29 , pp. 293-302
    • Berry-Kravis, E.1    Sumis, A.2    Hervey, C.3    Nelson, M.4    Porges, S.W.5    Weng, N.6
  • 22
    • 84862637069 scopus 로고    scopus 로고
    • The pathophysiology of fragile, X (and what it teaches us about synapses)
    • Bhakar, A. L., Dolen, G., and Bear, M. F. (2012). The pathophysiology of fragile, X (and what it teaches us about synapses). Annu. Rev. Neurosci. 35, 417-443. doi: 10.1146/annurev-neuro-060909-153138.
    • (2012) Annu. Rev. Neurosci. , vol.35 , pp. 417-443
    • Bhakar, A.L.1    Dolen, G.2    Bear, M.F.3
  • 23
    • 84867736998 scopus 로고    scopus 로고
    • Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic and behavioral phenotypes in fragile X syndrome mice
    • Bhattacharya, A., Kaphzan, H., Alvarez-Dieppa, A. C., Murphy, J. P., Pierre, P., and Klann, E. (2012). Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic and behavioral phenotypes in fragile X syndrome mice.Neuron 76, 325-337. doi: 10.1016/j.neuron.2012.07.022.
    • (2012) Neuron , vol.76 , pp. 325-337
    • Bhattacharya, A.1    Kaphzan, H.2    Alvarez-Dieppa, A.C.3    Murphy, J.P.4    Pierre, P.5    Klann, E.6
  • 24
    • 33646893456 scopus 로고    scopus 로고
    • Molecular genetics of Rett syndrome: When DNA methylation goes unrecognized
    • Bienvenu, T., and Chelly, J. (2006). Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized. Nat. Rev. Genet. 7, 415-426. doi: 10.1038/nrg1878.
    • (2006) Nat. Rev. Genet. , vol.7 , pp. 415-426
    • Bienvenu, T.1    Chelly, J.2
  • 25
    • 62149089881 scopus 로고    scopus 로고
    • Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model
    • Bilousova, T. V., Dansie, L., Ngo, M., Aye, J., Charles, J. R., Ethell, D. W., et al. (2009). Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model. J. Med. Genet. 46, 94-102. doi: 10.1136/jmg.2008.061796.
    • (2009) J. Med. Genet. , vol.46 , pp. 94-102
    • Bilousova, T.V.1    Dansie, L.2    Ngo, M.3    Aye, J.4    Charles, J.R.5    Ethell, D.W.6
  • 26
    • 80053015805 scopus 로고    scopus 로고
    • Temporal and regional alterations in NMDA receptor expression in Mecp2-null mice
    • Blue, M. E., Kaufmann, W. E., Bressler, J., Eyring, C., O’driscoll, C., Naidu, S., et al. (2011). Temporal and regional alterations in NMDA receptor expression in Mecp2-null mice. Anat. Rec. (Hoboken) 294, 1624-1634. doi: 10.1002/ar.21380.
    • (2011) Anat. Rec. (Hoboken) , vol.294 , pp. 1624-1634
    • Blue, M.E.1    Kaufmann, W.E.2    Bressler, J.3    Eyring, C.4    O’Driscoll, C.5    Naidu, S.6
  • 27
    • 0032945641 scopus 로고    scopus 로고
    • Development of amino acid receptors in frontal cortex from girls with Rett syndrome
    • Blue, M. E., Naidu, S., and Johnston, M. V. (1999). Development of amino acid receptors in frontal cortex from girls with Rett syndrome. Ann. Neurol. 45, 541-545. doi: 10.1002/1531-8249(199904)45:4<541::aid-ana21>3.0.co;2-2.
    • (1999) Ann. Neurol. , vol.45 , pp. 541-545
    • Blue, M.E.1    Naidu, S.2    Johnston, M.V.3
  • 28
    • 84898723842 scopus 로고    scopus 로고
    • Reversal of activity-mediated spine dynamics and learning impairment in a mouse model of Fragile X syndrome
    • Boda, B., Mendez, P., Boury-Jamot, B., Magara, F., and Muller, D. (2014). Reversal of activity-mediated spine dynamics and learning impairment in a mouse model of Fragile X syndrome. Eur. J. Neurosci. 39, 1130-1137. doi: 10.1111/ejn.12488.
    • (2014) Eur. J. Neurosci. , vol.39 , pp. 1130-1137
    • Boda, B.1    Mendez, P.2    Boury-Jamot, B.3    Magara, F.4    Muller, D.5
  • 29
    • 33646421164 scopus 로고    scopus 로고
    • Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase
    • Borrell-Pagès, M., Canals, J. M., Cordelières, F. P., Parker, J. A., Pineda, J. R., Grange, G., et al. (2006). Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J. Clin. Invest. 116, 1410-1424. doi: 10.1172/jci27607.
    • (2006) J. Clin. Invest. , vol.116 , pp. 1410-1424
    • Borrell-Pagès, M.1    Canals, J.M.2    Cordelières, F.P.3    Parker, J.A.4    Pineda, J.R.5    Grange, G.6
  • 30
    • 0033153034 scopus 로고    scopus 로고
    • Roles of metabotropic glutamate receptors in LTP and LTD in the hippocampus
    • Bortolotto, Z. A., Fitzjohn, S. M., and Collingridge, G. L. (1999). Roles of metabotropic glutamate receptors in LTP and LTD in the hippocampus. Curr. Opin. Neurobiol. 9, 299-304. doi: 10.1016/s0959-4388(99)80044-0.
    • (1999) Curr. Opin. Neurobiol. , vol.9 , pp. 299-304
    • Bortolotto, Z.A.1    Fitzjohn, S.M.2    Collingridge, G.L.3
  • 31
    • 84899579632 scopus 로고    scopus 로고
    • Fragile X syndrome neurobiology translates into rational therapy
    • Braat, S., and Kooy, R. F. (2014). Fragile X syndrome neurobiology translates into rational therapy. Drug Discov. Today 19, 510-519. doi: 10.1016/j.drudis.2014.01.013.
    • (2014) Drug Discov. Today , vol.19 , pp. 510-519
    • Braat, S.1    Kooy, R.F.2
  • 33
    • 79955748023 scopus 로고    scopus 로고
    • Readthrough of nonsense mutations in Rett syndrome: Evaluation of novel aminoglycosides and generation of a new mouse model
    • Brendel, C., Belakhov, V., Werner, H., Wegener, E., Gärtner, J., Nudelman, I., et al. (2011). Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model. J. Mol. Med. (Berl.) 89, 389-398. doi: 10.1007/s00109-010-0704-4.
    • (2011) J. Mol. Med. (Berl.) , vol.89 , pp. 389-398
    • Brendel, C.1    Belakhov, V.2    Werner, H.3    Wegener, E.4    Gärtner, J.5    Nudelman, I.6
  • 34
    • 77954145556 scopus 로고    scopus 로고
    • Fragile X mental retardation protein controls gating of the sodium-activated potassium channel slack
    • Brown, M. R., Kronengold, J., Gazula, V. R., Chen, Y., Strumbos, J. G., Sigworth, F. J., et al. (2010). Fragile X mental retardation protein controls gating of the sodium-activated potassium channel slack. Nat. Neurosci. 13, 819-821. doi: 10.1038/nn.2563.
    • (2010) Nat. Neurosci. , vol.13 , pp. 819-821
    • Brown, M.R.1    Kronengold, J.2    Gazula, V.R.3    Chen, Y.4    Strumbos, J.G.5    Sigworth, F.J.6
  • 35
    • 0023146784 scopus 로고
    • Reduced concentrations and increased metabolism of biogenic amines in a single case of Rett-syndrome: A postmortem brain study
    • Brücke, T., Sofic, E., Killian, W., Rett, A., and Riederer, P. (1987). Reduced concentrations and increased metabolism of biogenic amines in a single case of Rett-syndrome: a postmortem brain study. J. Neural Transm. 68, 315-324. doi: 10.1007/bf02098506.
    • (1987) J. Neural Transm. , vol.68 , pp. 315-324
    • Brücke, T.1    Sofic, E.2    Killian, W.3    Rett, A.4    Riederer, P.5
  • 36
    • 84890811053 scopus 로고    scopus 로고
    • Rapamycin improves sociability in the BTBR T(+)Itpr3(tf)/J mouse model of autism spectrum disorders
    • Burket, J. A., Benson, A. D., Tang, A. H., and Deutsch, S. I. (2014). Rapamycin improves sociability in the BTBR T(+)Itpr3(tf)/J mouse model of autism spectrum disorders. Brain Res. Bull. 100, 70-75. doi: 10.1016/j.brainresbull.2013.11.005.
    • (2014) Brain Res. Bull. , vol.100 , pp. 70-75
    • Burket, J.A.1    Benson, A.D.2    Tang, A.H.3    Deutsch, S.I.4
  • 38
    • 84910673035 scopus 로고    scopus 로고
    • Effect of lovastatin on behavior in children and adults with fragile X syndrome: An open-label study
    • Çaku, A., Pellerin, D., Bouvier, P., Riou, E., and Corbin, F. (2014). Effect of lovastatin on behavior in children and adults with fragile X syndrome: an open-label study. Am. J. Med. Genet. A 164A, 2834-2842. doi: 10.1002/ajmg.a.36750.
    • (2014) Am. J. Med. Genet. A , vol.164A , pp. 2834-2842
    • Çaku, A.1    Pellerin, D.2    Bouvier, P.3    Riou, E.4    Corbin, F.5
  • 39
    • 84921305880 scopus 로고    scopus 로고
    • Excitation/inhibition imbalance and impaired synaptic inhibition in hippocampal area CA3 of Mecp2 knockout mice
    • Calfa, G., Li, W., Rutherford, J. M., and Pozzo-Miller, L. (2015). Excitation/inhibition imbalance and impaired synaptic inhibition in hippocampal area CA3 of Mecp2 knockout mice. Hippocampus 25, 159-168. doi: 10.1002/hipo.22360.
    • (2015) Hippocampus , vol.25 , pp. 159-168
    • Calfa, G.1    Li, W.2    Rutherford, J.M.3    Pozzo-Miller, L.4
  • 40
    • 84867280540 scopus 로고    scopus 로고
    • Treatment of neurodevelopmental disorders in adulthood
    • Castrén, E., Elgersma, Y., Maffei, L., and Hagerman, R. (2012). Treatment of neurodevelopmental disorders in adulthood. J. Neurosci. 32, 14074-14079. doi: 10.1523/JNEUROSCI.3287-12.2012.
    • (2012) J. Neurosci. , vol.32 , pp. 14074-14079
    • Castrén, E.1    Elgersma, Y.2    Maffei, L.3    Hagerman, R.4
  • 41
    • 84903975689 scopus 로고    scopus 로고
    • Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett syndrome
    • Castro, J., Garcia, R. I., Kwok, S., Banerjee, A., Petravicz, J., Woodson, J., et al. (2014). Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett syndrome. Proc. Natl. Acad. Sci. U S A 111, 9941-9946. doi: 10.1073/pnas.1311685111.
    • (2014) Proc. Natl. Acad. Sci. U S A , vol.111 , pp. 9941-9946
    • Castro, J.1    Garcia, R.I.2    Kwok, S.3    Banerjee, A.4    Petravicz, J.5    Woodson, J.6
  • 42
    • 84874936217 scopus 로고    scopus 로고
    • Mechanisms and therapeutic challenges in autism spectrum disorders: Insights from Rett syndrome
    • Castro, J., Mellios, N., and Sur, M. (2013). Mechanisms and therapeutic challenges in autism spectrum disorders: insights from Rett syndrome. Curr. Opin. Neurol. 26, 154-159. doi: 10.1097/WCO.0b013e32835f19a7.
    • (2013) Curr. Opin. Neurol. , vol.26 , pp. 154-159
    • Castro, J.1    Mellios, N.2    Sur, M.3
  • 43
    • 84884140511 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of dopamine-mediated behavioral plasticity in the striatum
    • Cerovic, M., d’Isa, R., Tonini, R., and Brambilla, R. (2013). Molecular and cellular mechanisms of dopamine-mediated behavioral plasticity in the striatum. Neurobiol. Learn. Mem. 105, 63-80. doi: 10.1016/j.nlm.2013.06.013.
    • (2013) Neurobiol. Learn. Mem. , vol.105 , pp. 63-80
    • Cerovic, M.1    d’Isa, R.2    Tonini, R.3    Brambilla, R.4
  • 44
    • 35648978121 scopus 로고    scopus 로고
    • The story of Rett syndrome: From clinic to neurobiology
    • Chahrour, M., and Zoghbi, H. Y. (2007). The story of Rett syndrome: from clinic to neurobiology. Neuron 56, 422-437. doi: 10.1016/j.neuron.2007.10.001.
    • (2007) Neuron , vol.56 , pp. 422-437
    • Chahrour, M.1    Zoghbi, H.Y.2
  • 45
    • 41049102573 scopus 로고    scopus 로고
    • Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila
    • Chang, S., Bray, S. M., Li, Z., Zarnescu, D. C., He, C., Jin, P., et al. (2008). Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Nat. Chem. Biol. 4, 256-263. doi: 10.1038/nchembio.78.
    • (2008) Nat. Chem. Biol. , vol.4 , pp. 256-263
    • Chang, S.1    Bray, S.M.2    Li, Z.3    Zarnescu, D.C.4    He, C.5    Jin, P.6
  • 46
    • 31444434393 scopus 로고    scopus 로고
    • The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression
    • Chang, Q., Khare, G., Dani, V., Nelson, S., and Jaenisch, R. (2006). The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron 49, 341-348. doi: 10.1016/j.neuron.2005.12.027.
    • (2006) Neuron , vol.49 , pp. 341-348
    • Chang, Q.1    Khare, G.2    Dani, V.3    Nelson, S.4    Jaenisch, R.5
  • 47
    • 78149431869 scopus 로고    scopus 로고
    • Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
    • Chao, H. T., Chen, H., Samaco, R. C., Xue, M., Chahrour, M., Yoo, J., et al. (2010). Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature 468, 263-269. doi: 10.1038/nature09582.
    • (2010) Nature , vol.468 , pp. 263-269
    • Chao, H.T.1    Chen, H.2    Samaco, R.C.3    Xue, M.4    Chahrour, M.5    Yoo, J.6
  • 48
    • 84871191102 scopus 로고    scopus 로고
    • Recent progress in Rett syndrome and MeCP2 Dysfunction: Assessment of potential treatment options
    • Chapleau, C. A., Lane, J., Larimore, J., Li, W., Pozzo-Miller, L., and Percy, A. K. (2013b). Recent progress in Rett syndrome and MeCP2 Dysfunction: assessment of potential treatment options. Future Neurol. 8, 21-28. doi: 10.2217/fnl.12.79.
    • (2013) Future Neurol. , vol.8 , pp. 21-28
    • Chapleau, C.A.1    Lane, J.2    Larimore, J.3    Li, W.4    Pozzo-Miller, L.5    Percy, A.K.6
  • 49
    • 84906933431 scopus 로고    scopus 로고
    • Evaluation of current pharmacological treatment options in the management of Rett syndrome: From the present to future therapeutic alternatives
    • Chapleau, C. A., Lane, J., Pozzo-Miller, L., and Percy, A. K. (2013a). Evaluation of current pharmacological treatment options in the management of Rett syndrome: from the present to future therapeutic alternatives. Curr. Clin. Pharmacol. 8, 358-369. doi: 10.2174/15748847113086660069.
    • (2013) Curr. Clin. Pharmacol. , vol.8 , pp. 358-369
    • Chapleau, C.A.1    Lane, J.2    Pozzo-Miller, L.3    Percy, A.K.4
  • 50
    • 78751500005 scopus 로고    scopus 로고
    • Modulation of dendritic spine development and plasticity by BDNF and vesicular trafficking: Fundamental roles in neurodevelopmental disorders associated with mental retardation and autism
    • Chapleau, C. A., Larimore, J. L., Theibert, A., and Pozzo-Miller, L. (2009). Modulation of dendritic spine development and plasticity by BDNF and vesicular trafficking: fundamental roles in neurodevelopmental disorders associated with mental retardation and autism. J. Neurodev. Disord. 1, 185-196. doi: 10.1007/s11689-009-9027-6.
    • (2009) J. Neurodev. Disord. , vol.1 , pp. 185-196
    • Chapleau, C.A.1    Larimore, J.L.2    Theibert, A.3    Pozzo-Miller, L.4
  • 51
    • 0035093830 scopus 로고    scopus 로고
    • Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
    • Chen, R. Z., Akbarian, S., Tudor, M., and Jaenisch, R. (2001). Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat. Genet. 27, 327-331. doi: 10.1038/85906.
    • (2001) Nat. Genet. , vol.27 , pp. 327-331
    • Chen, R.Z.1    Akbarian, S.2    Tudor, M.3    Jaenisch, R.4
  • 52
    • 0242332183 scopus 로고    scopus 로고
    • Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2
    • Chen, W. G., Chang, Q., Lin, Y., Meissner, A., West, A. E., Griffith, E. C., et al. (2003). Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 302, 885-889. doi: 10.1126/science.1086446.
    • (2003) Science , vol.302 , pp. 885-889
    • Chen, W.G.1    Chang, Q.2    Lin, Y.3    Meissner, A.4    West, A.E.5    Griffith, E.C.6
  • 53
    • 77955914539 scopus 로고    scopus 로고
    • Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome
    • Chen, L. Y., Rex, C. S., Babayan, A. H., Kramár, E. A., Lynch, G., Gall, C. M., et al. (2010). Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome. J. Neurosci. 30, 10977-10984. doi: 10.1523/JNEUROSCI.1077-10.2010.
    • (2010) J. Neurosci. , vol.30 , pp. 10977-10984
    • Chen, L.Y.1    Rex, C.S.2    Babayan, A.H.3    Kramár, E.A.4    Lynch, G.5    Gall, C.M.6
  • 54
    • 84864951981 scopus 로고    scopus 로고
    • Astrocytes and developmental plasticity in fragile X
    • Cheng, C., Sourial, M., and Doering, L. C. (2012). Astrocytes and developmental plasticity in fragile X. Neural Plast.2012:197491. doi: 10.1155/2012/197491.
    • (2012) Neural Plast. , vol.2012
    • Cheng, C.1    Sourial, M.2    Doering, L.C.3
  • 55
    • 33745706730 scopus 로고    scopus 로고
    • Endocannabinoid-mediated synaptic plasticity in the CNS
    • Chevaleyre, V., Takahashi, K. A., and Castillo, P. E. (2006). Endocannabinoid-mediated synaptic plasticity in the CNS. Annu. Rev. Neurosci. 29, 37-76. doi: 10.1146/annurev.neuro.29.051605.112834.
    • (2006) Annu. Rev. Neurosci. , vol.29 , pp. 37-76
    • Chevaleyre, V.1    Takahashi, K.A.2    Castillo, P.E.3
  • 56
    • 34250731835 scopus 로고    scopus 로고
    • Memantine as adjunctive therapy in children diagnosed with autistic spectrum disorders: An observation of initial clinical response and maintenance tolerability
    • Chez, M. G., Burton, Q., Dowling, T., Chang, M., Khanna, P., and Kramer, C. (2007). Memantine as adjunctive therapy in children diagnosed with autistic spectrum disorders: an observation of initial clinical response and maintenance tolerability. J. Child Neurol. 22, 574-579. doi: 10.1177/0883073807302611.
    • (2007) J. Child Neurol. , vol.22 , pp. 574-579
    • Chez, M.G.1    Burton, Q.2    Dowling, T.3    Chang, M.4    Khanna, P.5    Kramer, C.6
  • 57
    • 77957019846 scopus 로고    scopus 로고
    • Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders
    • Chiu, C. T., and Chuang, D. M. (2010). Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders. Pharmacol. Ther. 128, 281-304. doi: 10.1016/j.pharmthera.2010.07.006.
    • (2010) Pharmacol. Ther. , vol.128 , pp. 281-304
    • Chiu, C.T.1    Chuang, D.M.2
  • 58
    • 0036345677 scopus 로고    scopus 로고
    • Role of altered brain serotonin mechanisms in autism
    • Chugani, D. C. (2002). Role of altered brain serotonin mechanisms in autism. Mol. Psychiatry 7(Suppl. 2), S16-S17. doi: 10.1038/sj.mp.4001167.
    • (2002) Mol. Psychiatry , vol.7 , pp. S16-S17
    • Chugani, D.C.1
  • 59
    • 77953280825 scopus 로고    scopus 로고
    • Reversibility of functional deficits in experimental models of Rett syndrome
    • Cobb, S., Guy, J., and Bird, A. (2010). Reversibility of functional deficits in experimental models of Rett syndrome.Biochem. Soc. Trans. 38, 498-506. doi: 10.1042/BST0380498.
    • (2010) Biochem. Soc. Trans. , vol.38 , pp. 498-506
    • Cobb, S.1    Guy, J.2    Bird, A.3
  • 60
    • 80053579176 scopus 로고    scopus 로고
    • Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function
    • Cohen, S., Gabel, H. W., Hemberg, M., Hutchinson, A. N., Sadacca, L. A., Ebert, D. H., et al. (2011). Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function. Neuron 72, 72-85. doi: 10.1016/j.neuron.2011.08.022.
    • (2011) Neuron , vol.72 , pp. 72-85
    • Cohen, S.1    Gabel, H.W.2    Hemberg, M.3    Hutchinson, A.N.4    Sadacca, L.A.5    Ebert, D.H.6
  • 61
    • 3042635178 scopus 로고    scopus 로고
    • GSK3 inhibitors: Development and therapeutic potential
    • Cohen, P., and Goedert, M. (2004). GSK3 inhibitors: development and therapeutic potential. Nat. Rev. Drug Discov.3, 479-487. doi: 10.1038/nrd1415.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 479-487
    • Cohen, P.1    Goedert, M.2
  • 63
    • 84862154850 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 (IGF1) and its active peptide (1-3)IGF1 enhance the expression of synaptic markers in neuronal circuits through different cellular mechanisms
    • Corvin, A. P., Molinos, I., Little, G., Donohoe, G., Gill, M., Morris, D. W., et al. (2012). Insulin-like growth factor 1 (IGF1) and its active peptide (1-3)IGF1 enhance the expression of synaptic markers in neuronal circuits through different cellular mechanisms. Neurosci. Lett. 520, 51-56. doi: 10.1016/j.neulet.2012.05.029.
    • (2012) Neurosci. Lett. , vol.520 , pp. 51-56
    • Corvin, A.P.1    Molinos, I.2    Little, G.3    Donohoe, G.4    Gill, M.5    Morris, D.W.6
  • 64
    • 84868198902 scopus 로고    scopus 로고
    • Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X syndrome
    • Costa, L., Spatuzza, M., D’Antoni, S., Bonaccorso, C. M., Trovato, C., Musumeci, S. A., et al. (2012). Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X syndrome. Biol. Psychiatry 72, 924-933. doi: 10.1016/j.biopsych.2012.06.008.
    • (2012) Biol. Psychiatry , vol.72 , pp. 924-933
    • Costa, L.1    Spatuzza, M.2    D’Antoni, S.3    Bonaccorso, C.M.4    Trovato, C.5    Musumeci, S.A.6
  • 65
    • 79951990962 scopus 로고    scopus 로고
    • Phosphoinositide-3-kinase activation controls synaptogenesis and spinogenesis in hippocampal neurons
    • Cuesto, G., Enriquez-Barreto, L., Caramés, C., Cantarero, M., Gasull, X., Sandi, C., et al. (2011). Phosphoinositide-3-kinase activation controls synaptogenesis and spinogenesis in hippocampal neurons. J. Neurosci. 31, 2721-2733. doi: 10.1523/JNEUROSCI.4477-10.2011.
    • (2011) J. Neurosci. , vol.31 , pp. 2721-2733
    • Cuesto, G.1    Enriquez-Barreto, L.2    Caramés, C.3    Cantarero, M.4    Gasull, X.5    Sandi, C.6
  • 66
    • 84875970431 scopus 로고    scopus 로고
    • Resilience to audiogenic seizures is associated with p-ERK1/2 dephosphorylation in the subiculum of Fmr1 knockout mice
    • Curia, G., Gualtieri, F., Bartolomeo, R., Vezzali, R., and Biagini, G. (2013). Resilience to audiogenic seizures is associated with p-ERK1/2 dephosphorylation in the subiculum of Fmr1 knockout mice. Front. Cell. Neurosci. 7:46. doi: 10.3389/fncel.2013.00046.
    • (2013) Front. Cell. Neurosci. , vol.7 , pp. 46
    • Curia, G.1    Gualtieri, F.2    Bartolomeo, R.3    Vezzali, R.4    Biagini, G.5
  • 67
    • 84878921815 scopus 로고    scopus 로고
    • Long-lasting effects of minocycline on behavior in young but not adult Fragile X mice
    • Dansie, L. E., Phommahaxay, K., Okusanya, A. G., Uwadia, J., Huang, M., Rotschafer, S. E., et al. (2013). Long-lasting effects of minocycline on behavior in young but not adult Fragile X mice. Neuroscience 246, 186-198. doi: 10.1016/j.neuroscience.2013.04.058.
    • (2013) Neuroscience , vol.246 , pp. 186-198
    • Dansie, L.E.1    Phommahaxay, K.2    Okusanya, A.G.3    Uwadia, J.4    Huang, M.5    Rotschafer, S.E.6
  • 68
    • 84886953546 scopus 로고    scopus 로고
    • The translation of translational control by FMRP: Therapeutic targets for FXS
    • Darnell, J. C., and Klann, E. (2013). The translation of translational control by FMRP: therapeutic targets for FXS.Nat. Neurosci. 16, 1530-1536. doi: 10.1038/nn.3379.
    • (2013) Nat. Neurosci. , vol.16 , pp. 1530-1536
    • Darnell, J.C.1    Klann, E.2
  • 70
    • 84880297402 scopus 로고    scopus 로고
    • Progress toward treatments for synaptic defects in autism
    • Delorme, R., Ey, E., Toro, R., Leboyer, M., Gillberg, C., and Bourgeron, T. (2013). Progress toward treatments for synaptic defects in autism. Nat. Med. 19, 685-694. doi: 10.1038/nm.3193.
    • (2013) Nat. Med. , vol.19 , pp. 685-694
    • Delorme, R.1    Ey, E.2    Toro, R.3    Leboyer, M.4    Gillberg, C.5    Bourgeron, T.6
  • 71
    • 84874256375 scopus 로고    scopus 로고
    • FMRP regulates neurotransmitter release and synaptic information transmission by modulating action potential duration via BK channels
    • Deng, P. Y., Rotman, Z., Blundon, J. A., Cho, Y., Cui, J., Cavalli, V., et al. (2013). FMRP regulates neurotransmitter release and synaptic information transmission by modulating action potential duration via BK channels. Neuron77, 696-711. doi: 10.1016/j.neuron.2012.12.018.
    • (2013) Neuron , vol.77 , pp. 696-711
    • Deng, P.Y.1    Rotman, Z.2    Blundon, J.A.3    Cho, Y.4    Cui, J.5    Cavalli, V.6
  • 72
    • 84865538160 scopus 로고    scopus 로고
    • Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome
    • Deogracias, R., Yazdani, M., Dekkers, M. P., Guy, J., Ionescu, M. C., Vogt, K. E., et al. (2012). Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome. Proc. Natl. Acad. Sci. U S A 109, 14230-14235. doi: 10.1073/pnas.1206093109.
    • (2012) Proc. Natl. Acad. Sci. U S A , vol.109 , pp. 14230-14235
    • Deogracias, R.1    Yazdani, M.2    Dekkers, M.P.3    Guy, J.4    Ionescu, M.C.5    Vogt, K.E.6
  • 73
    • 84875234176 scopus 로고    scopus 로고
    • The role of microglia in brain maintenance: Implications for Rett syndrome
    • Derecki, N. C., Cronk, J. C., and Kipnis, J. (2013). The role of microglia in brain maintenance: implications for Rett syndrome. Trends Immunol. 34, 144-150. doi: 10.1016/j.it.2012.10.002.
    • (2013) Trends Immunol. , vol.34 , pp. 144-150
    • Derecki, N.C.1    Cronk, J.C.2    Kipnis, J.3
  • 74
    • 32444434874 scopus 로고    scopus 로고
    • Autism and the serotonin transporter: The long and short of it
    • Devlin, B., Cook, E. H. Jr., Coon, H., Dawson, G., Grigorenko, E. L., McMahon, W., et al. (2005). Autism and the serotonin transporter: the long and short of it. Mol. Psychiatry 10, 1110-1116. doi: 10.1038/sj.mp.4001724.
    • (2005) Mol. Psychiatry , vol.10 , pp. 1110-1116
    • Devlin, B.1    Cook, E.H.2    Coon, H.3    Dawson, G.4    Grigorenko, E.L.5    McMahon, W.6
  • 76
    • 33750726094 scopus 로고    scopus 로고
    • Decreased expression of the GABAA receptor in fragile X syndrome
    • D’Hulst, C., De Geest, N., Reeve, S. P., Van Dam, D., De Deyn, P. P., Hassan, B. A., et al. (2006). Decreased expression of the GABAA receptor in fragile X syndrome. Brain Res. 1121, 238-245. doi: 10.1016/j.brainres.2006.08.115.
    • (2006) Brain Res. , vol.1121 , pp. 238-245
    • D’Hulst, C.1    De Geest, N.2    Reeve, S.P.3    Van Dam, D.4    De Deyn, P.P.5    Hassan, B.A.6
  • 77
    • 58249135425 scopus 로고    scopus 로고
    • Expression of the GABAergic system in animal models for fragile X syndrome and fragile X associated tremor/ataxia syndrome (FXTAS)
    • D’Hulst, C., Heulens, I., Brouwer, J. R., Willemsen, R., De Geest, N., Reeve, S. P., et al. (2009). Expression of the GABAergic system in animal models for fragile X syndrome and fragile X associated tremor/ataxia syndrome (FXTAS). Brain Res. 1253, 176-183. doi: 10.1016/j.brainres.2008.11.075.
    • (2009) Brain Res. , vol.1253 , pp. 176-183
    • D’Hulst, C.1    Heulens, I.2    Brouwer, J.R.3    Willemsen, R.4    De Geest, N.5    Reeve, S.P.6
  • 78
    • 84875844949 scopus 로고    scopus 로고
    • Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486
    • Dolan, B. M., Duron, S. G., Campbell, D. A., Vollrath, B., Shankaranarayana Rao, B. S., Ko, H. Y., et al. (2013). Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486. Proc. Natl. Acad. Sci. U S A 110, 5671-5676. doi: 10.1073/pnas.1219383110.
    • (2013) Proc. Natl. Acad. Sci. U S A , vol.110 , pp. 5671-5676
    • Dolan, B.M.1    Duron, S.G.2    Campbell, D.A.3    Vollrath, B.4    Shankaranarayana Rao, B.S.5    Ko, H.Y.6
  • 79
    • 40949090052 scopus 로고    scopus 로고
    • Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome
    • Dölen, G., and Bear, M. F. (2008). Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome. J. Physiol. 586, 1503-1508. doi: 10.1113/jphysiol.2008.150722.
    • (2008) J. Physiol. , vol.586 , pp. 1503-1508
    • Dölen, G.1    Bear, M.F.2
  • 80
    • 84893578436 scopus 로고    scopus 로고
    • Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models
    • Doll, C. A., and Broadie, K. (2014). Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models. Front. Cell. Neurosci. 8:30. doi: 10.3389/fncel.2014.00030.
    • (2014) Front. Cell. Neurosci. , vol.8 , pp. 30
    • Doll, C.A.1    Broadie, K.2
  • 81
    • 84880041880 scopus 로고    scopus 로고
    • Effects of intranasal oxytocin on the neural basis of face processing in autism spectrum disorder
    • Domes, G., Heinrichs, M., Kumbier, E., Grossmann, A., Hauenstein, K., and Herpertz, S. C. (2013). Effects of intranasal oxytocin on the neural basis of face processing in autism spectrum disorder. Biol. Psychiatry 74, 164-171. doi: 10.1016/j.biopsych.2013.02.007.
    • (2013) Biol. Psychiatry , vol.74 , pp. 164-171
    • Domes, G.1    Heinrichs, M.2    Kumbier, E.3    Grossmann, A.4    Hauenstein, K.5    Herpertz, S.C.6
  • 82
    • 84871371030 scopus 로고    scopus 로고
    • NMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2
    • Durand, S., Patrizi, A., Quast, K. B., Hachigian, L., Pavlyuk, R., Saxena, A., et al. (2012). NMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2. Neuron 76, 1078-1090. doi: 10.1016/j.neuron.2012.12.004.
    • (2012) Neuron , vol.76 , pp. 1078-1090
    • Durand, S.1    Patrizi, A.2    Quast, K.B.3    Hachigian, L.4    Pavlyuk, R.5    Saxena, A.6
  • 83
    • 84880746947 scopus 로고    scopus 로고
    • High MMP-9 activity levels in fragile X syndrome are lowered by minocycline
    • Dziembowska, M., Pretto, D. I., Janusz, A., Kaczmarek, L., Leigh, M. J., Gabriel, N., et al. (2013). High MMP-9 activity levels in fragile X syndrome are lowered by minocycline. Am. J. Med. Genet. A 161A, 1897-1903. doi: 10.1002/ajmg.a.36023.
    • (2013) Am. J. Med. Genet. A , vol.161A , pp. 1897-1903
    • Dziembowska, M.1    Pretto, D.I.2    Janusz, A.3    Kaczmarek, L.4    Leigh, M.J.5    Gabriel, N.6
  • 84
    • 84856115427 scopus 로고    scopus 로고
    • NMDA receptor hypofunction in the dentate gyrus and impaired context discrimination in adult Fmr1 knockout mice
    • Eadie, B. D., Cushman, J., Kannangara, T. S., Fanselow, M. S., and Christie, B. R. (2012). NMDA receptor hypofunction in the dentate gyrus and impaired context discrimination in adult Fmr1 knockout mice.Hippocampus 22, 241-254. doi: 10.1002/hipo.20890.
    • (2012) Hippocampus , vol.22 , pp. 241-254
    • Eadie, B.D.1    Cushman, J.2    Kannangara, T.S.3    Fanselow, M.S.4    Christie, B.R.5
  • 85
    • 84872593582 scopus 로고    scopus 로고
    • Activity-dependent neuronal signalling and autism spectrum disorder
    • Ebert, D. H., and Greenberg, M. E. (2013). Activity-dependent neuronal signalling and autism spectrum disorder.Nature 493, 327-337. doi: 10.1038/nature11860.
    • (2013) Nature , vol.493 , pp. 327-337
    • Ebert, D.H.1    Greenberg, M.E.2
  • 86
    • 33745887507 scopus 로고    scopus 로고
    • Memantine for disruptive behavior in autistic disorder
    • Erickson, C. A., and Chambers, J. E. (2006). Memantine for disruptive behavior in autistic disorder. J. Clin. Psychiatry 67:1000. doi: 10.4088/jcp.v67n0619h.
    • (2006) J. Clin. Psychiatry , vol.67 , pp. 1000
    • Erickson, C.A.1    Chambers, J.E.2
  • 87
    • 70450247105 scopus 로고    scopus 로고
    • Open-label memantine in fragile X syndrome
    • Erickson, C. A., Mullett, J. E., and McDougle, C. J. (2009). Open-label memantine in fragile X syndrome. J. Autism Dev. Disord. 39, 1629-1635. doi: 10.1007/s10803-009-0807-3.
    • (2009) J. Autism Dev. Disord. , vol.39 , pp. 1629-1635
    • Erickson, C.A.1    Mullett, J.E.2    McDougle, C.J.3
  • 88
    • 78549286298 scopus 로고    scopus 로고
    • Brief report: Acamprosate in fragile X syndrome
    • Erickson, C. A., Mullett, J. E., and McDougle, C. J. (2010). Brief report: acamprosate in fragile X syndrome. J. Autism Dev. Disord. 40, 1412-1416. doi: 10.1007/s10803-010-0988-9.
    • (2010) J. Autism Dev. Disord. , vol.40 , pp. 1412-1416
    • Erickson, C.A.1    Mullett, J.E.2    McDougle, C.J.3
  • 89
    • 84879238323 scopus 로고    scopus 로고
    • Impact of acamprosate on behavior and brain-derived neurotrophic factor: An open-label study in youth with fragile X syndrome
    • Erickson, C. A., Wink, L. K., Ray, B., Early, M. C., Stiegelmeyer, E., Mathieu-Frasier, L., et al. (2013). Impact of acamprosate on behavior and brain-derived neurotrophic factor: an open-label study in youth with fragile X syndrome. Psychopharmacology (Berl) 228, 75-84. doi: 10.1007/s00213-013-3022-z.
    • (2013) Psychopharmacology (Berl) , vol.228 , pp. 75-84
    • Erickson, C.A.1    Wink, L.K.2    Ray, B.3    Early, M.C.4    Stiegelmeyer, E.5    Mathieu-Frasier, L.6
  • 90
    • 34547957954 scopus 로고    scopus 로고
    • Matrix metalloproteinases in brain development and remodeling: Synaptic functions and targets
    • Ethell, I. M., and Ethell, D. W. (2007). Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets. J. Neurosci. Res. 85, 2813-2823. doi: 10.1002/jnr.21273.
    • (2007) J. Neurosci. Res. , vol.85 , pp. 2813-2823
    • Ethell, I.M.1    Ethell, D.W.2
  • 91
    • 84891593130 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 inhibitors reverse deficits in long-term potentiation and cognition in fragile X mice
    • Franklin, A. V., King, M. K., Palomo, V., Martinez, A., McMahon, L. L., and Jope, R. S. (2014). Glycogen synthase kinase-3 inhibitors reverse deficits in long-term potentiation and cognition in fragile X mice. Biol. Psychiatry 75, 198-206. doi: 10.1016/j.biopsych.2013.08.003.
    • (2014) Biol. Psychiatry , vol.75 , pp. 198-206
    • Franklin, A.V.1    King, M.K.2    Palomo, V.3    Martinez, A.4    McMahon, L.L.5    Jope, R.S.6
  • 92
    • 77958479803 scopus 로고    scopus 로고
    • Dopamine release and uptake impairments and behavioral alterations observed in mice that model fragile X mental retardation syndrome
    • Fulks, J. L., O’Bryhim, B. E., Wenzel, S. K., Fowler, S. C., Vorontsova, E., Pinkston, J. W., et al. (2010). Dopamine release and uptake impairments and behavioral alterations observed in mice that model fragile X mental retardation syndrome. ACS Chem. Neurosci. 1, 679-690. doi: 10.1021/cn100032f.
    • (2010) ACS Chem. Neurosci. , vol.1 , pp. 679-690
    • Fulks, J.L.1    O’Bryhim, B.E.2    Wenzel, S.K.3    Fowler, S.C.4    Vorontsova, E.5    Pinkston, J.W.6
  • 93
    • 80052696272 scopus 로고    scopus 로고
    • MeCP2 and Rett syndrome: Reversibility and potential avenues for therapy
    • Gadalla, K. K., Bailey, M. E., and Cobb, S. R. (2011). MeCP2 and Rett syndrome: reversibility and potential avenues for therapy. Biochem. J. 439, 1-14. doi: 10.1042/bj20110648.
    • (2011) Biochem. J. , vol.439 , pp. 1-14
    • Gadalla, K.K.1    Bailey, M.E.2    Cobb, S.R.3
  • 94
    • 84896913124 scopus 로고    scopus 로고
    • 2-Methyl-6-(phenylethynyl) pyridine (MPEP) reverses maze learning and PSD-95 deficits in Fmr1 knock-out mice
    • Gandhi, R. M., Kogan, C. S., and Messier, C. (2014). 2-Methyl-6-(phenylethynyl) pyridine (MPEP) reverses maze learning and PSD-95 deficits in Fmr1 knock-out mice. Front. Cell. Neurosci. 8:70. doi: 10.3389/fncel.2014.00070.
    • (2014) Front. Cell. Neurosci. , vol.8 , pp. 70
    • Gandhi, R.M.1    Kogan, C.S.2    Messier, C.3
  • 95
    • 84869861822 scopus 로고    scopus 로고
    • Chronic administration of AFQ056/Mavoglurant restores social behaviour in Fmr1 knockout mice
    • Gantois, I., Pop, A. S., de Esch, C. E., Buijsen, R. A., Pooters, T., Gomez-Mancilla, B., et al. (2013). Chronic administration of AFQ056/Mavoglurant restores social behaviour in Fmr1 knockout mice. Behav. Brain Res. 239, 72-79. doi: 10.1016/j.bbr.2012.10.059.
    • (2013) Behav. Brain Res. , vol.239 , pp. 72-79
    • Gantois, I.1    Pop, A.S.2    de Esch, C.E.3    Buijsen, R.A.4    Pooters, T.5    Gomez-Mancilla, B.6
  • 97
    • 84862068720 scopus 로고    scopus 로고
    • Regulation of neuronal GABA(B) receptor functions by subunit composition
    • Gassmann, M., and Bettler, B. (2012). Regulation of neuronal GABA(B) receptor functions by subunit composition.Nat. Rev. Neurosci. 13, 380-394. doi: 10.1038/nrn3249.
    • (2012) Nat. Rev. Neurosci. , vol.13 , pp. 380-394
    • Gassmann, M.1    Bettler, B.2
  • 100
    • 84872595085 scopus 로고    scopus 로고
    • Autism-related deficits via dysregulated eIF4E-dependent translational control
    • Gkogkas, C. G., Khoutorsky, A., Ran, I., Rampakakis, E., Nevarko, T., Weatherill, D. B., et al. (2013). Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature 493, 371-377. doi: 10.1038/nature11628.
    • (2013) Nature , vol.493 , pp. 371-377
    • Gkogkas, C.G.1    Khoutorsky, A.2    Ran, I.3    Rampakakis, E.4    Nevarko, T.5    Weatherill, D.B.6
  • 101
    • 77950503200 scopus 로고    scopus 로고
    • Epilepsy and the natural history of Rett syndrome
    • Glaze, D. G., Percy, A. K., Skinner, S., Motil, K. J., Neul, J. L., Barrish, J. O., et al. (2010). Epilepsy and the natural history of Rett syndrome. Neurology 74, 909-912. doi: 10.1212/wnl.0b013e3181d6b852.
    • (2010) Neurology , vol.74 , pp. 909-912
    • Glaze, D.G.1    Percy, A.K.2    Skinner, S.3    Motil, K.J.4    Neul, J.L.5    Barrish, J.O.6
  • 102
    • 84865281952 scopus 로고    scopus 로고
    • Synaptic NMDA receptor-mediated currents in anterior piriform cortex are reduced in the adult fragile X mouse
    • Gocel, J., and Larson, J. (2012). Synaptic NMDA receptor-mediated currents in anterior piriform cortex are reduced in the adult fragile X mouse. Neuroscience 221, 170-181. doi: 10.1016/j.neuroscience.2012.06.052.
    • (2012) Neuroscience , vol.221 , pp. 170-181
    • Gocel, J.1    Larson, J.2
  • 103
    • 83455179319 scopus 로고    scopus 로고
    • Therapeutic implications for striatal-enriched protein tyrosine phosphatase (STEP) in neuropsychiatric disorders
    • Goebel-Goody, S. M., Baum, M., Paspalas, C. D., Fernandez, S. M., Carty, N. C., Kurup, P., et al. (2012b). Therapeutic implications for striatal-enriched protein tyrosine phosphatase (STEP) in neuropsychiatric disorders. Pharmacol. Rev. 64, 65-87. doi: 10.1124/pr.110.003053.
    • (2012) Pharmacol. Rev. , vol.64 , pp. 65-87
    • Goebel-Goody, S.M.1    Baum, M.2    Paspalas, C.D.3    Fernandez, S.M.4    Carty, N.C.5    Kurup, P.6
  • 104
    • 80455158054 scopus 로고    scopus 로고
    • Taking STEPs forward to understand fragile X syndrome
    • Goebel-Goody, S. M., and Lombroso, P. J. (2012). Taking STEPs forward to understand fragile X syndrome. Results Probl. Cell Differ. 54, 223-241. doi: 10.1007/978-3-642-21649-7_12.
    • (2012) Results Probl. Cell Differ. , vol.54 , pp. 223-241
    • Goebel-Goody, S.M.1    Lombroso, P.J.2
  • 105
    • 84863333644 scopus 로고    scopus 로고
    • Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model
    • Goebel-Goody, S. M., Wilson-Wallis, E. D., Royston, S., Tagliatela, S. M., Naegele, J. R., and Lombroso, P. J. (2012a). Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model. Genes Brain Behav. 11, 586-600. doi: 10.1111/j.1601-183x.2012.00781.x.
    • (2012) Genes Brain Behav. , vol.11 , pp. 586-600
    • Goebel-Goody, S.M.1    Wilson-Wallis, E.D.2    Royston, S.3    Tagliatela, S.M.4    Naegele, J.R.5    Lombroso, P.J.6
  • 107
    • 34248172449 scopus 로고    scopus 로고
    • Structure and functions of the human amyloid precursor protein: The whole is more than the sum of its parts
    • Gralle, M., and Ferreira, S. T. (2007). Structure and functions of the human amyloid precursor protein: the whole is more than the sum of its parts. Prog. Neurobiol. 82, 11-32. doi: 10.1016/j.pneurobio.2007.02.001.
    • (2007) Prog. Neurobiol. , vol.82 , pp. 11-32
    • Gralle, M.1    Ferreira, S.T.2
  • 108
    • 84860568814 scopus 로고    scopus 로고
    • Excess protein synthesis in FXS patient lymphoblastoid cells can be rescued with a p110beta-selective inhibitor
    • Gross, C., and Bassell, G. J. (2012). Excess protein synthesis in FXS patient lymphoblastoid cells can be rescued with a p110beta-selective inhibitor. Mol. Med. 18, 336-345. doi: 10.2119/molmed.2011.00363.
    • (2012) Mol. Med. , vol.18 , pp. 336-345
    • Gross, C.1    Bassell, G.J.2
  • 109
    • 84894110828 scopus 로고    scopus 로고
    • Neuron-specific regulation of class I PI3K catalytic subunits and their dysfunction in brain disorders
    • Gross, C., and Bassell, G. J. (2014). Neuron-specific regulation of class I PI3K catalytic subunits and their dysfunction in brain disorders. Front. Mol. Neurosci. 7:12. doi: 10.3389/fnmol.2014.00012.
    • (2014) Front. Mol. Neurosci. , vol.7 , pp. 12
    • Gross, C.1    Bassell, G.J.2
  • 110
    • 84856078399 scopus 로고    scopus 로고
    • Therapeutic strategies in fragile X syndrome: Dysregulated mGluR signaling and beyond
    • Gross, C., Berry-Kravis, E. M., and Bassell, G. J. (2012). Therapeutic strategies in fragile X syndrome: dysregulated mGluR signaling and beyond. Neuropsychopharmacology 37, 178-195. doi: 10.1038/npp.2011.137.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 178-195
    • Gross, C.1    Berry-Kravis, E.M.2    Bassell, G.J.3
  • 111
    • 77956209418 scopus 로고    scopus 로고
    • Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome
    • Gross, C., Nakamoto, M., Yao, X., Chan, C. B., Yim, S. Y., Ye, K., et al. (2010). Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome. J. Neurosci. 30, 10624-10638. doi: 10.1523/jneurosci.0402-10.2010.
    • (2010) J. Neurosci. , vol.30 , pp. 10624-10638
    • Gross, C.1    Nakamoto, M.2    Yao, X.3    Chan, C.B.4    Yim, S.Y.5    Ye, K.6
  • 112
    • 79955748180 scopus 로고    scopus 로고
    • Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2
    • Gross, C., Yao, X., Pong, D. L., Jeromin, A., and Bassell, G. J. (2011). Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2. J. Neurosci. 31, 5693-5698. doi: 10.1523/jneurosci.6661-10.2011.
    • (2011) J. Neurosci. , vol.31 , pp. 5693-5698
    • Gross, C.1    Yao, X.2    Pong, D.L.3    Jeromin, A.4    Bassell, G.J.5
  • 113
    • 84862908964 scopus 로고    scopus 로고
    • Inhibition of GSK3beta improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome
    • Guo, W., Murthy, A. C., Zhang, L., Johnson, E. B., Schaller, E. G., Allan, A. M., et al. (2012). Inhibition of GSK3beta improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome.Hum. Mol. Genet. 21, 681-691. doi: 10.1093/hmg/ddr501.
    • (2012) Hum. Mol. Genet. , vol.21 , pp. 681-691
    • Guo, W.1    Murthy, A.C.2    Zhang, L.3    Johnson, E.B.4    Schaller, E.G.5    Allan, A.M.6
  • 115
    • 33847266846 scopus 로고    scopus 로고
    • Reversal of neurological defects in a mouse model of Rett syndrome
    • Guy, J., Gan, J., Selfridge, J., Cobb, S., and Bird, A. (2007). Reversal of neurological defects in a mouse model of Rett syndrome. Science 315, 1143-1147. doi: 10.1126/science.1138389.
    • (2007) Science , vol.315 , pp. 1143-1147
    • Guy, J.1    Gan, J.2    Selfridge, J.3    Cobb, S.4    Bird, A.5
  • 116
    • 0035094767 scopus 로고    scopus 로고
    • A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
    • Guy, J., Hendrich, B., Holmes, M., Martin, J. E., and Bird, A. (2001). A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat. Genet. 27, 322-326. doi: 10.1038/85899.
    • (2001) Nat. Genet. , vol.27 , pp. 322-326
    • Guy, J.1    Hendrich, B.2    Holmes, M.3    Martin, J.E.4    Bird, A.5
  • 117
    • 0020507697 scopus 로고
    • A progressive syndrome of autism, dementia, ataxia and loss of purposeful hand use in girls: Rett’s syndrome: Report of 35 cases
    • Hagberg, B., Aicardi, J., Dias, K., and Ramos, O. (1983). A progressive syndrome of autism, dementia, ataxia and loss of purposeful hand use in girls: Rett’s syndrome: report of 35 cases. Ann. Neurol. 14, 471-479. doi: 10.1002/ana.410140412.
    • (1983) Ann. Neurol. , vol.14 , pp. 471-479
    • Hagberg, B.1    Aicardi, J.2    Dias, K.3    Ramos, O.4
  • 119
    • 0033515582 scopus 로고    scopus 로고
    • Fragile X syndrome and selective mutism
    • Hagerman, R. J., Hills, J., Scharfenaker, S., and Lewis, H. (1999). Fragile X syndrome and selective mutism. Am. J. Med. Genet. 83, 313-317. doi: 10.1002/(sici)1096-8628(19990402)83:4<313::aid-ajmg15>3.0.co;2-f.
    • (1999) Am. J. Med. Genet. , vol.83 , pp. 313-317
    • Hagerman, R.J.1    Hills, J.2    Scharfenaker, S.3    Lewis, H.4
  • 120
    • 84922403583 scopus 로고    scopus 로고
    • Treatment of the psychiatric problems associated with fragile X syndrome
    • Hagerman, R. J., and Polussa, J. (2015). Treatment of the psychiatric problems associated with fragile X syndrome.Curr. Opin. Psychiatry 28, 107-112. doi: 10.1097/yco.0000000000000131.
    • (2015) Curr. Opin. Psychiatry , vol.28 , pp. 107-112
    • Hagerman, R.J.1    Polussa, J.2
  • 121
    • 84857192799 scopus 로고    scopus 로고
    • Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome
    • Hall, S. S., Lightbody, A. A., McCarthy, B. E., Parker, K. J., and Reiss, A. L. (2012). Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome. Psychoneuroendocrinology 37, 509-518. doi: 10.1016/j.psyneuen.2011.07.020.
    • (2012) Psychoneuroendocrinology , vol.37 , pp. 509-518
    • Hall, S.S.1    Lightbody, A.A.2    McCarthy, B.E.3    Parker, K.J.4    Reiss, A.L.5
  • 122
    • 84879217408 scopus 로고    scopus 로고
    • Serotonin hypothesis of autism: Implications for selective serotonin reuptake inhibitor use during pregnancy
    • Harrington, R. A., Lee, L. C., Crum, R. M., Zimmerman, A. W., and Hertz-Picciotto, I. (2013). Serotonin hypothesis of autism: implications for selective serotonin reuptake inhibitor use during pregnancy. Autism Res. 6, 149-168. doi: 10.1002/aur.1288.
    • (2013) Autism Res. , vol.6 , pp. 149-168
    • Harrington, R.A.1    Lee, L.C.2    Crum, R.M.3    Zimmerman, A.W.4    Hertz-Picciotto, I.5
  • 123
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay, N., and Sonenberg, N. (2004). Upstream and downstream of mTOR. Genes Dev. 18, 1926-1945. doi: 10.1101/gad.1212704.
    • (2004) Genes Dev. , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 124
    • 2942583823 scopus 로고    scopus 로고
    • Altered cortical synaptic morphology and impaired memory consolidation in forebrain-specific dominant-negative PAK transgenic mice
    • Hayashi, M. L., Choi, S. Y., Rao, B. S., Jung, H. Y., Lee, H. K., Zhang, D., et al. (2004). Altered cortical synaptic morphology and impaired memory consolidation in forebrain-specific dominant-negative PAK transgenic mice.Neuron 42, 773-787. doi: 10.1016/j.neuron.2004.05.003.
    • (2004) Neuron , vol.42 , pp. 773-787
    • Hayashi, M.L.1    Choi, S.Y.2    Rao, B.S.3    Jung, H.Y.4    Lee, H.K.5    Zhang, D.6
  • 125
    • 34547433543 scopus 로고    scopus 로고
    • Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice
    • Hayashi, M. L., Rao, B. S., Seo, J. S., Choi, H. S., Dolan, B. M., Choi, S. Y., et al. (2007). Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice. Proc. Natl. Acad. Sci. U S A 104, 11489-11494. doi: 10.1073/pnas.0705003104.
    • (2007) Proc. Natl. Acad. Sci. U S A , vol.104 , pp. 11489-11494
    • Hayashi, M.L.1    Rao, B.S.2    Seo, J.S.3    Choi, H.S.4    Dolan, B.M.5    Choi, S.Y.6
  • 126
    • 80053654735 scopus 로고    scopus 로고
    • Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry
    • Hays, S. A., Huber, K. M., and Gibson, J. R. (2011). Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry. J. Neurosci. 31, 14223-14234. doi: 10.1523/jneurosci.3157-11.2011.
    • (2011) J. Neurosci. , vol.31 , pp. 14223-14234
    • Hays, S.A.1    Huber, K.M.2    Gibson, J.R.3
  • 127
    • 84891750581 scopus 로고    scopus 로고
    • The developmental switch in GABA polarity is delayed in fragile X mice
    • He, Q., Nomura, T., Xu, J., and Contractor, A. (2014). The developmental switch in GABA polarity is delayed in fragile X mice. J. Neurosci. 34, 446-450. doi: 10.1523/jneurosci.4447-13.2014.
    • (2014) J. Neurosci. , vol.34 , pp. 446-450
    • He, Q.1    Nomura, T.2    Xu, J.3    Contractor, A.4
  • 128
    • 84906965053 scopus 로고    scopus 로고
    • Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule
    • Hebert, B., Pietropaolo, S., Meme, S., Laudier, B., Laugeray, A., Doisne, N., et al. (2014). Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule. Orphanet J. Rare Dis. 9:124. doi: 10.1186/s13023-014-0124-6.
    • (2014) Orphanet J. Rare Dis. , vol.9 , pp. 124
    • Hebert, B.1    Pietropaolo, S.2    Meme, S.3    Laudier, B.4    Laugeray, A.5    Doisne, N.6
  • 129
    • 67651173255 scopus 로고    scopus 로고
    • Endocannabinoid signaling and long-term synaptic plasticity
    • Heifets, B. D., and Castillo, P. E. (2009). Endocannabinoid signaling and long-term synaptic plasticity. Annu. Rev. Physiol. 71, 283-306. doi: 10.1146/annurev.physiol.010908.163149.
    • (2009) Annu. Rev. Physiol. , vol.71 , pp. 283-306
    • Heifets, B.D.1    Castillo, P.E.2
  • 130
    • 84866615813 scopus 로고    scopus 로고
    • Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen
    • Henderson, C., Wijetunge, L., Kinoshita, M. N., Shumway, M., Hammond, R. S., Postma, F. R., et al. (2012). Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen. Sci. Transl. Med. 4:152ra128. doi: 10.1126/scitranslmed.3004218.
    • (2012) Sci. Transl. Med. , vol.4
    • Henderson, C.1    Wijetunge, L.2    Kinoshita, M.N.3    Shumway, M.4    Hammond, R.S.5    Postma, F.R.6
  • 131
    • 84894454320 scopus 로고    scopus 로고
    • A solution to limitations of cognitive testing in children with intellectual disabilities: The case of fragile X syndrome
    • Hessl, D., Nguyen, D. V., Green, C., Chavez, A., Tassone, F., Hagerman, R. J., et al. (2009). A solution to limitations of cognitive testing in children with intellectual disabilities: the case of fragile X syndrome. J. Neurodev. Disord. 1, 33-45. doi: 10.1007/s11689-008-9001-8.
    • (2009) J. Neurodev. Disord. , vol.1 , pp. 33-45
    • Hessl, D.1    Nguyen, D.V.2    Green, C.3    Chavez, A.4    Tassone, F.5    Hagerman, R.J.6
  • 132
    • 84856578911 scopus 로고    scopus 로고
    • Pharmacological treatment of fragile X syndrome with GABAergic drugs in a knockout mouse model
    • Heulens, I., D’Hulst, C., Van Dam, D., De Deyn, P. P., and Kooy, R. F. (2012). Pharmacological treatment of fragile X syndrome with GABAergic drugs in a knockout mouse model. Behav. Brain Res. 229, 244-249. doi: 10.1016/j.bbr.2012.01.031.
    • (2012) Behav. Brain Res. , vol.229 , pp. 244-249
    • Heulens, I.1    D’Hulst, C.2    Van Dam, D.3    De Deyn, P.P.4    Kooy, R.F.5
  • 133
    • 75749114797 scopus 로고    scopus 로고
    • mTOR signaling: At the crossroads of plasticity, memory and disease
    • Hoeffer, C. A., and Klann, E. (2010). mTOR signaling: at the crossroads of plasticity, memory and disease. Trends Neurosci. 33, 67-75. doi: 10.1016/j.tins.2009.11.003.
    • (2010) Trends Neurosci. , vol.33 , pp. 67-75
    • Hoeffer, C.A.1    Klann, E.2
  • 134
    • 84859420878 scopus 로고    scopus 로고
    • Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome
    • Hoeffer, C. A., Sanchez, E., Hagerman, R. J., Mu, Y., Nguyen, D. V., Wong, H., et al. (2012). Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome. Genes Brain Behav. 11, 332-341. doi: 10.1111/j.1601-183x.2012.00768.x.
    • (2012) Genes Brain Behav. , vol.11 , pp. 332-341
    • Hoeffer, C.A.1    Sanchez, E.2    Hagerman, R.J.3    Mu, Y.4    Nguyen, D.V.5    Wong, H.6
  • 135
    • 13944264748 scopus 로고    scopus 로고
    • A placebo controlled crossover trial of liquid fluoxetine on repetitive behaviors in childhood and adolescent autism
    • Hollander, E., Phillips, A., Chaplin, W., Zagursky, K., Novotny, S., Wasserman, S., et al. (2005). A placebo controlled crossover trial of liquid fluoxetine on repetitive behaviors in childhood and adolescent autism.Neuropsychopharmacology 30, 582-589. doi: 10.1038/sj.npp.1300627.
    • (2005) Neuropsychopharmacology , vol.30 , pp. 582-589
    • Hollander, E.1    Phillips, A.2    Chaplin, W.3    Zagursky, K.4    Novotny, S.5    Wasserman, S.6
  • 136
    • 84858971972 scopus 로고    scopus 로고
    • A double-blind placebo-controlled trial of fluoxetine for repetitive behaviors and global severity in adult autism spectrum disorders
    • Hollander, E., Soorya, L., Chaplin, W., Anagnostou, E., Taylor, B. P., Ferretti, C. J., et al. (2012). A double-blind placebo-controlled trial of fluoxetine for repetitive behaviors and global severity in adult autism spectrum disorders. Am. J. Psychiatry 169, 292-299. doi: 10.1176/appi.ajp.2011.10050764.
    • (2012) Am. J. Psychiatry , vol.169 , pp. 292-299
    • Hollander, E.1    Soorya, L.2    Chaplin, W.3    Anagnostou, E.4    Taylor, B.P.5    Ferretti, C.J.6
  • 137
    • 33745215607 scopus 로고    scopus 로고
    • Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat
    • Horwood, J. M., Dufour, F., Laroche, S., and Davis, S. (2006). Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat. Eur. J. Neurosci. 23, 3375-3384. doi: 10.1111/j.1460-9568.2006.04859.x.
    • (2006) Eur. J. Neurosci. , vol.23 , pp. 3375-3384
    • Horwood, J.M.1    Dufour, F.2    Laroche, S.3    Davis, S.4
  • 138
    • 50349090344 scopus 로고    scopus 로고
    • Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome
    • Hu, H., Qin, Y., Bochorishvili, G., Zhu, Y., van Aelst, L., and Zhu, J. J. (2008). Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome. J. Neurosci. 28, 7847-7862. doi: 10.1523/jneurosci.1496-08.2008.
    • (2008) J. Neurosci. , vol.28 , pp. 7847-7862
    • Hu, H.1    Qin, Y.2    Bochorishvili, G.3    Zhu, Y.4    van Aelst, L.5    Zhu, J.J.6
  • 139
    • 84884338166 scopus 로고    scopus 로고
    • The genetic landscapes of autism spectrum disorders
    • Huguet, G., Ey, E., and Bourgeron, T. (2013). The genetic landscapes of autism spectrum disorders. Annu. Rev. Genomics Hum. Genet. 14, 191-213. doi: 10.1146/annurev-genom-091212-153431.
    • (2013) Annu. Rev. Genomics Hum. Genet. , vol.14 , pp. 191-213
    • Huguet, G.1    Ey, E.2    Bourgeron, T.3
  • 140
    • 84867745968 scopus 로고    scopus 로고
    • Synaptic circuit remodelling by matrix metalloproteinases in health and disease
    • Huntley, G. W. (2012). Synaptic circuit remodelling by matrix metalloproteinases in health and disease. Nat. Rev. Neurosci. 13, 743-757. doi: 10.1038/nrn3320.
    • (2012) Nat. Rev. Neurosci. , vol.13 , pp. 743-757
    • Huntley, G.W.1
  • 141
    • 55049131112 scopus 로고    scopus 로고
    • Minocycline increases phosphorylation and membrane insertion of neuronal GluR1 receptors
    • Imbesi, M., Uz, T., Manev, R., Sharma, R. P., and Manev, H. (2008). Minocycline increases phosphorylation and membrane insertion of neuronal GluR1 receptors. Neurosci. Lett. 447, 134-137. doi: 10.1016/j.neulet.2008.10.006.
    • (2008) Neurosci. Lett. , vol.447 , pp. 134-137
    • Imbesi, M.1    Uz, T.2    Manev, R.3    Sharma, R.P.4    Manev, H.5
  • 143
    • 78650937072 scopus 로고    scopus 로고
    • Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056
    • Jacquemont, S., Curie, A., des Portes, V., Torrioli, M. G., Berry-Kravis, E., Hagerman, R. J., et al. (2011). Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056. Sci. Transl. Med. 3:64ra61. doi: 10.1126/scitranslmed.3001708.
    • (2011) Sci. Transl. Med. , vol.3
    • Jacquemont, S.1    Curie, A.2    des Portes, V.3    Torrioli, M.G.4    Berry-Kravis, E.5    Hagerman, R.J.6
  • 144
    • 84887344195 scopus 로고    scopus 로고
    • The fragile X mental retardation protein regulates matrix metalloproteinase 9 mRNA at synapses
    • Janusz, A., Milek, J., Perycz, M., Pacini, L., Bagni, C., Kaczmarek, L., et al. (2013). The fragile X mental retardation protein regulates matrix metalloproteinase 9 mRNA at synapses. J. Neurosci. 33, 18234-18241. doi: 10.1523/JNEUROSCI.2207-13.2013.
    • (2013) J. Neurosci. , vol.33 , pp. 18234-18241
    • Janusz, A.1    Milek, J.2    Perycz, M.3    Pacini, L.4    Bagni, C.5    Kaczmarek, L.6
  • 145
    • 0038445711 scopus 로고    scopus 로고
    • Dopamine: A potential substrate for synaptic plasticity and memory mechanisms
    • Jay, T. M. (2003). Dopamine: a potential substrate for synaptic plasticity and memory mechanisms. Prog. Neurobiol. 69, 375-390. doi: 10.1016/s0301-0082(03)00085-6.
    • (2003) Prog. Neurobiol. , vol.69 , pp. 375-390
    • Jay, T.M.1
  • 146
    • 33750866196 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions
    • Jope, R. S., and Roh, M. S. (2006). Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions. Curr. Drug Targets 7, 1421-1434. doi: 10.2174/1389450110607011421.
    • (2006) Curr. Drug Targets , vol.7 , pp. 1421-1434
    • Jope, R.S.1    Roh, M.S.2
  • 147
    • 0037381336 scopus 로고    scopus 로고
    • The expression of methyl CpG binding factor MeCP2 correlates with cellular differentiation in the developing rat brain and in cultured cells
    • Jung, B. P., Jugloff, D. G., Zhang, G., Logan, R., Brown, S., and Eubanks, J. H. (2003). The expression of methyl CpG binding factor MeCP2 correlates with cellular differentiation in the developing rat brain and in cultured cells. J. Neurobiol. 55, 86-96. doi: 10.1002/neu.10201.
    • (2003) J. Neurobiol. , vol.55 , pp. 86-96
    • Jung, B.P.1    Jugloff, D.G.2    Zhang, G.3    Logan, R.4    Brown, S.5    Eubanks, J.H.6
  • 148
    • 84867013830 scopus 로고    scopus 로고
    • Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome
    • Jung, K. M., Sepers, M., Henstridge, C. M., Lassalle, O., Neuhofer, D., Martin, H., et al. (2012). Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome. Nat. Commun. 3:1080. doi: 10.1038/ncomms2045.
    • (2012) Nat. Commun. , vol.3 , pp. 1080
    • Jung, K.M.1    Sepers, M.2    Henstridge, C.M.3    Lassalle, O.4    Neuhofer, D.5    Martin, H.6
  • 149
    • 84906569100 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and Rett syndrome
    • Katz, D. M. (2014). Brain-derived neurotrophic factor and Rett syndrome. Handb. Exp. Pharmacol. 220, 481-495. doi: 10.1007/978-3-642-45106-5_18.
    • (2014) Handb. Exp. Pharmacol. , vol.220 , pp. 481-495
    • Katz, D.M.1
  • 150
  • 151
    • 1342322145 scopus 로고    scopus 로고
    • Translational control by MAPK signaling in long-term synaptic plasticity and memory
    • Kelleher, R. J. 3rd, Govindarajan, A., Jung, H. Y., Kang, H., and Tonegawa, S. (2004). Translational control by MAPK signaling in long-term synaptic plasticity and memory. Cell 116, 467-479. doi: 10.1016/s0092-8674(04)00115-1.
    • (2004) Cell , vol.116 , pp. 467-479
    • Kelleher, R.J.1    Govindarajan, A.2    Jung, H.Y.3    Kang, H.4    Tonegawa, S.5
  • 152
    • 84896912072 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome
    • Khwaja, O. S., Ho, E., Barnes, K. V., O’Leary, H. M., Pereira, L. M., Finkelstein, Y., et al. (2014). Safety, pharmacokinetics and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome. Proc. Natl. Acad. Sci. U S A 111, 4596-4601. doi: 10.1073/pnas.1311141111.
    • (2014) Proc. Natl. Acad. Sci. U S A , vol.111 , pp. 4596-4601
    • Khwaja, O.S.1    Ho, E.2    Barnes, K.V.3    O’Leary, H.M.4    Pereira, L.M.5    Finkelstein, Y.6
  • 153
    • 84905157802 scopus 로고    scopus 로고
    • Emerging role of the KCNT1 Slack channel in intellectual disability
    • Kim, G. E., and Kaczmarek, L. K. (2014). Emerging role of the KCNT1 Slack channel in intellectual disability. Front. Cell. Neurosci. 8:209. doi: 10.3389/fncel.2014.00209.
    • (2014) Front. Cell. Neurosci. , vol.8 , pp. 209
    • Kim, G.E.1    Kaczmarek, L.K.2
  • 154
    • 41949135731 scopus 로고    scopus 로고
    • Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome
    • Kim, S. H., Markham, J. A., Weiler, I. J., and Greenough, W. T. (2008). Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome. Proc. Natl. Acad. Sci. U S A 105, 4429-4434. doi: 10.1073/pnas.0800257105.
    • (2008) Proc. Natl. Acad. Sci. U S A , vol.105 , pp. 4429-4434
    • Kim, S.H.1    Markham, J.A.2    Weiler, I.J.3    Greenough, W.T.4
  • 155
    • 84884988657 scopus 로고    scopus 로고
    • Lithium treatment alleviates impaired cognition in a mouse model of fragile X syndrome
    • King, M. K., and Jope, R. S. (2013). Lithium treatment alleviates impaired cognition in a mouse model of fragile X syndrome. Genes Brain Behav. 12, 723-731. doi: 10.1111/gbb.12071.
    • (2013) Genes Brain Behav. , vol.12 , pp. 723-731
    • King, M.K.1    Jope, R.S.2
  • 156
    • 32344450824 scopus 로고    scopus 로고
    • Genomic DNA methylation: The mark and its mediators
    • Klose, R. J., and Bird, A. P. (2006). Genomic DNA methylation: the mark and its mediators. Trends Biochem. Sci.31, 89-97. doi: 10.1016/j.tibs.2005.12.008.
    • (2006) Trends Biochem. Sci. , vol.31 , pp. 89-97
    • Klose, R.J.1    Bird, A.P.2
  • 157
    • 84894064252 scopus 로고    scopus 로고
    • Evolution of oxytocin pathways in the brain of vertebrates
    • Knobloch, H. S., and Grinevich, V. (2014). Evolution of oxytocin pathways in the brain of vertebrates. Front. Behav. Neurosci. 8:31. doi: 10.3389/fnbeh.2014.00031.
    • (2014) Front. Behav. Neurosci. , vol.8 , pp. 31
    • Knobloch, H.S.1    Grinevich, V.2
  • 158
    • 33645754287 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitors in autism: A review of efficacy and tolerability
    • Kolevzon, A., Mathewson, K. A., and Hollander, E. (2006). Selective serotonin reuptake inhibitors in autism: a review of efficacy and tolerability. J. Clin. Psychiatry 67, 407-414. doi: 10.4088/jcp.v67n0311.
    • (2006) J. Clin. Psychiatry , vol.67 , pp. 407-414
    • Kolevzon, A.1    Mathewson, K.A.2    Hollander, E.3
  • 159
    • 58249128132 scopus 로고    scopus 로고
    • PAK signalling in neuronal physiology
    • Kreis, P., and Barnier, J. V. (2009). PAK signalling in neuronal physiology. Cell. Signal. 21, 384-393. doi: 10.1016/j.cellsig.2008.11.001.
    • (2009) Cell. Signal. , vol.21 , pp. 384-393
    • Kreis, P.1    Barnier, J.V.2
  • 160
    • 84866981228 scopus 로고    scopus 로고
    • Brain activity mapping in Mecp2 mutant mice reveals functional deficits in forebrain circuits, including key nodes in the default mode network, that are reversed with ketamine treatment
    • Kron, M., Howell, C. J., Adams, I. T., Ransbottom, M., Christian, D., Ogier, M., et al. (2012). Brain activity mapping in Mecp2 mutant mice reveals functional deficits in forebrain circuits, including key nodes in the default mode network, that are reversed with ketamine treatment. J. Neurosci. 32, 13860-13872. doi: 10.1523/JNEUROSCI.2159-12.2012.
    • (2012) J. Neurosci. , vol.32 , pp. 13860-13872
    • Kron, M.1    Howell, C.J.2    Adams, I.T.3    Ransbottom, M.4    Christian, D.5    Ogier, M.6
  • 161
    • 84907192606 scopus 로고    scopus 로고
    • A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome
    • Kron, M., Lang, M., Adams, I. T., Sceniak, M., Longo, F., and Katz, D. M. (2014). A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome. Dis. Model. Mech. 7, 1047-1055. doi: 10.1242/dmm.016030.
    • (2014) Dis. Model. Mech. , vol.7 , pp. 1047-1055
    • Kron, M.1    Lang, M.2    Adams, I.T.3    Sceniak, M.4    Longo, F.5    Katz, D.M.6
  • 162
    • 79952301339 scopus 로고    scopus 로고
    • Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome
    • Krueger, D. D., Osterweil, E. K., Chen, S. P., Tye, L. D., and Bear, M. F. (2011). Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome. Proc. Natl. Acad. Sci. U S A 108, 2587-2592. doi: 10.1073/pnas.1013855108.
    • (2011) Proc. Natl. Acad. Sci. U S A , vol.108 , pp. 2587-2592
    • Krueger, D.D.1    Osterweil, E.K.2    Chen, S.P.3    Tye, L.D.4    Bear, M.F.5
  • 163
    • 84893708713 scopus 로고    scopus 로고
    • A de novo convergence of autism genetics and molecular neuroscience
    • Krumm, N., O’Roak, B. J., Shendure, J., and Eichler, E. E. (2014). A de novo convergence of autism genetics and molecular neuroscience. Trends Neurosci. 37, 95-105. doi: 10.1016/j.tins.2013.11.005.
    • (2014) Trends Neurosci. , vol.37 , pp. 95-105
    • Krumm, N.1    O’Roak, B.J.2    Shendure, J.3    Eichler, E.E.4
  • 164
    • 84887081316 scopus 로고    scopus 로고
    • Agonist-dependent signaling by group I metabotropic glutamate receptors is regulated by association with lipid domains
    • Kumari, R., Castillo, C., and Francesconi, A. (2013). Agonist-dependent signaling by group I metabotropic glutamate receptors is regulated by association with lipid domains. J. Biol. Chem. 288, 32004-32019. doi: 10.1074/jbc.M113.475863.
    • (2013) J. Biol. Chem. , vol.288 , pp. 32004-32019
    • Kumari, R.1    Castillo, C.2    Francesconi, A.3
  • 166
    • 84867302438 scopus 로고    scopus 로고
    • A call for transparent reporting to optimize the predictive value of preclinical research
    • Landis, S. C., Amara, S. G., Asadullah, K., Austin, C. P., Blumenstein, R., Bradley, E. W., et al. (2012). A call for transparent reporting to optimize the predictive value of preclinical research. Nature 490, 187-191. doi: 10.1038/nature11556.
    • (2012) Nature , vol.490 , pp. 187-191
    • Landis, S.C.1    Amara, S.G.2    Asadullah, K.3    Austin, C.P.4    Blumenstein, R.5    Bradley, E.W.6
  • 167
    • 0035880454 scopus 로고    scopus 로고
    • Quantitative localization of heterogeneous methyl-CpG-binding protein 2 (MeCP2) expression phenotypes in normal and Rett syndrome brain by laser scanning cytometry
    • LaSalle, J. M., Goldstine, J., Balmer, D., and Greco, C. M. (2001). Quantitative localization of heterogeneous methyl-CpG-binding protein 2 (MeCP2) expression phenotypes in normal and Rett syndrome brain by laser scanning cytometry. Hum. Mol. Genet. 10, 1729-1740. doi: 10.1093/hmg/10.17.1729.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 1729-1740
    • LaSalle, J.M.1    Goldstine, J.2    Balmer, D.3    Greco, C.M.4
  • 170
    • 84155177066 scopus 로고    scopus 로고
    • Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein
    • Lee, H. Y., Ge, W. P., Huang, W., He, Y., Wang, G. X., Rowson-Baldwin, A., et al. (2011). Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein. Neuron 72, 630-642. doi: 10.1016/j.neuron.2011.09.033..
    • (2011) Neuron , vol.72 , pp. 630-642
    • Lee, H.Y.1    Ge, W.P.2    Huang, W.3    He, Y.4    Wang, G.X.5    Rowson-Baldwin, A.6
  • 171
    • 84868214380 scopus 로고    scopus 로고
    • Fragile X syndrome: Mechanistic insights and therapeutic avenues regarding the role of potassium channels
    • Lee, H. Y., and Jan, L. Y. (2012). Fragile X syndrome: mechanistic insights and therapeutic avenues regarding the role of potassium channels. Curr. Opin. Neurobiol. 22, 887-894. doi: 10.1016/j.conb.2012.03.010.
    • (2012) Curr. Opin. Neurobiol. , vol.22 , pp. 887-894
    • Lee, H.Y.1    Jan, L.Y.2
  • 172
    • 84876358587 scopus 로고    scopus 로고
    • A randomized double-blind, placebo-controlled trial of minocycline in children and adolescents with fragile x syndrome
    • Leigh, M. J., Nguyen, D. V., Mu, Y., Winarni, T. I., Schneider, A., Chechi, T., et al. (2013). A randomized double-blind, placebo-controlled trial of minocycline in children and adolescents with fragile x syndrome. J. Dev. Behav. Pediatr. 34, 147-155. doi: 10.1097/DBP.0b013e318287cd17.
    • (2013) J. Dev. Behav. Pediatr. , vol.34 , pp. 147-155
    • Leigh, M.J.1    Nguyen, D.V.2    Mu, Y.3    Winarni, T.I.4    Schneider, A.5    Chechi, T.6
  • 174
    • 84867120199 scopus 로고    scopus 로고
    • Serotonin in the modulation of neural plasticity and networks: Implications for neurodevelopmental disorders
    • Lesch, K. P., and Waider, J. (2012). Serotonin in the modulation of neural plasticity and networks: implications for neurodevelopmental disorders. Neuron 76, 175-191. doi: 10.1016/j.neuron.2012.09.013.
    • (2012) Neuron , vol.76 , pp. 175-191
    • Lesch, K.P.1    Waider, J.2
  • 176
    • 84890441953 scopus 로고    scopus 로고
    • BDNF deregulation in Rett syndrome
    • Li, W., and Pozzo-Miller, L. (2014). BDNF deregulation in Rett syndrome. Neuropharmacology 76(Pt. C), 737-746. doi: 10.1016/j.neuropharm.2013.03.024.
    • (2014) Neuropharmacology , vol.76 , pp. 737-746
    • Li, W.1    Pozzo-Miller, L.2
  • 177
    • 84893485922 scopus 로고    scopus 로고
    • Pharmacological rescue of Ras signaling, GluA1-dependent synaptic plasticity and learning deficits in a fragile X model
    • Lim, C. S., Hoang, E. T., Viar, K. E., Stornetta, R. L., Scott, M. M., and Zhu, J. J. (2014). Pharmacological rescue of Ras signaling, GluA1-dependent synaptic plasticity and learning deficits in a fragile X model. Genes Dev. 28, 273-289. doi: 10.1101/gad.232470.113.
    • (2014) Genes Dev. , vol.28 , pp. 273-289
    • Lim, C.S.1    Hoang, E.T.2    Viar, K.E.3    Stornetta, R.L.4    Scott, M.M.5    Zhu, J.J.6
  • 178
    • 84872731409 scopus 로고    scopus 로고
    • Fragile X syndrome therapeutics: Translation, meet translational medicine
    • Lipton, J., and Sahin, M. (2013). Fragile X syndrome therapeutics: translation, meet translational medicine. Neuron77, 212-213. doi: 10.1016/j.neuron.2013.01.009.
    • (2013) Neuron , vol.77 , pp. 212-213
    • Lipton, J.1    Sahin, M.2
  • 179
    • 77952421253 scopus 로고    scopus 로고
    • Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA
    • Maccarrone, M., Rossi, S., Bari, M., De Chiara, V., Rapino, C., Musella, A., et al. (2010). Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA. Neuropsychopharmacology 35, 1500-1509. doi: 10.1038/npp.2010.19.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 1500-1509
    • McCarrone, M.1    Rossi, S.2    Bari, M.3    De Chiara, V.4    Rapino, C.5    Musella, A.6
  • 180
    • 77953122395 scopus 로고    scopus 로고
    • Diminished prevalence but preserved synaptic distribution of N-methyl-D-aspartate receptor subunits in the methyl CpG binding protein 2(MeCP2)-null mouse brain
    • Maliszewska-Cyna, E., Bawa, D., and Eubanks, J. H. (2010). Diminished prevalence but preserved synaptic distribution of N-methyl-D-aspartate receptor subunits in the methyl CpG binding protein 2(MeCP2)-null mouse brain. Neuroscience 168, 624-632. doi: 10.1016/j.neuroscience.2010.03.065.
    • (2010) Neuroscience , vol.168 , pp. 624-632
    • Maliszewska-Cyna, E.1    Bawa, D.2    Eubanks, J.H.3
  • 181
    • 77952474914 scopus 로고    scopus 로고
    • Fragile X syndrome and Alzheimer’s disease: Another story about APP and beta-amyloid
    • Malter, J. S., Ray, B. C., Westmark, P. R., and Westmark, C. J. (2010). Fragile X syndrome and Alzheimer’s disease: another story about APP and beta-amyloid. Curr. Alzheimer Res. 7, 200-206. doi: 10.2174/156720510791050957.
    • (2010) Curr. Alzheimer Res. , vol.7 , pp. 200-206
    • Malter, J.S.1    Ray, B.C.2    Westmark, P.R.3    Westmark, C.J.4
  • 182
    • 78149488365 scopus 로고    scopus 로고
    • A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells
    • Marchetto, M. C., Carromeu, C., Acab, A., Yu, D., Yeo, G. W., Mu, Y., et al. (2010). A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 143, 527-539. doi: 10.1016/j.cell.2010.10.016.
    • (2010) Cell , vol.143 , pp. 527-539
    • Marchetto, M.C.1    Carromeu, C.2    Acab, A.3    Yu, D.4    Yeo, G.W.5    Mu, Y.6
  • 183
    • 0242300612 scopus 로고    scopus 로고
    • DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation
    • Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., et al. (2003). DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 302, 890-893. doi: 10.1126/science.1090842.
    • (2003) Science , vol.302 , pp. 890-893
    • Martinowich, K.1    Hattori, D.2    Wu, H.3    Fouse, S.4    He, F.5    Hu, Y.6
  • 184
    • 77951855933 scopus 로고    scopus 로고
    • Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents
    • Massa, S. M., Yang, T., Xie, Y., Shi, J., Bilgen, M., Joyce, J. N., et al. (2010). Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J. Clin. Invest. 120, 1774-1785. doi: 10.1172/JCI41356.
    • (2010) J. Clin. Invest. , vol.120 , pp. 1774-1785
    • Massa, S.M.1    Yang, T.2    Xie, Y.3    Shi, J.4    Bilgen, M.5    Joyce, J.N.6
  • 185
    • 79958269376 scopus 로고    scopus 로고
    • Role of the 5-HT7 receptor in the central nervous system: From current status to future perspectives
    • Matthys, A., Haegeman, G., Van Craenenbroeck, K., and Vanhoenacker, P. (2011). Role of the 5-HT7 receptor in the central nervous system: from current status to future perspectives. Mol. Neurobiol. 43, 228-253. doi: 10.1007/s12035-011-8175-3.
    • (2011) Mol. Neurobiol. , vol.43 , pp. 228-253
    • Matthys, A.1    Haegeman, G.2    Van Craenenbroeck, K.3    Vanhoenacker, P.4
  • 186
    • 83655193397 scopus 로고    scopus 로고
    • Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: Implication for therapy in Rett syndrome
    • McCauley, M. D., Wang, T., Mike, E., Herrera, J., Beavers, D. L., Huang, T. W., et al. (2011). Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndrome. Sci. Transl. Med.3:113ra125. doi: 10.1126/scitranslmed.3002982.
    • (2011) Sci. Transl. Med. , vol.3
    • McCauley, M.D.1    Wang, T.2    Mike, E.3    Herrera, J.4    Beavers, D.L.5    Huang, T.W.6
  • 187
    • 35348917593 scopus 로고    scopus 로고
    • Muscarinic receptor dependent long-term depression in rat visual cortex is PKC independent but requires ERK1/2 activation and protein synthesis
    • McCoy, P. A., and McMahon, L. L. (2007). Muscarinic receptor dependent long-term depression in rat visual cortex is PKC independent but requires ERK1/2 activation and protein synthesis. J. Neurophysiol. 98, 1862-1870. doi: 10.1152/jn.00510.2007.
    • (2007) J. Neurophysiol. , vol.98 , pp. 1862-1870
    • McCoy, P.A.1    McMahon, L.L.2
  • 188
    • 77249090207 scopus 로고    scopus 로고
    • The neurobiological properties of tianeptine (Stablon): From monoamine hypothesis to glutamatergic modulation
    • McEwen, B. S., Chattarji, S., Diamond, D. M., Jay, T. M., Reagan, L. P., Svenningsson, P., et al. (2010). The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation. Mol. Psychiatry 15, 237-249. doi: 10.1038/mp.2009.80.
    • (2010) Mol. Psychiatry , vol.15 , pp. 237-249
    • McEwen, B.S.1    Chattarji, S.2    Diamond, D.M.3    Jay, T.M.4    Reagan, L.P.5    Svenningsson, P.6
  • 189
    • 38349055166 scopus 로고    scopus 로고
    • Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome
    • Medrihan, L., Tantalaki, E., Aramuni, G., Sargsyan, V., Dudanova, I., Missler, M., et al. (2008). Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome. J. Neurophysiol. 99, 112-121. doi: 10.1152/jn.00826.2007.
    • (2008) J. Neurophysiol. , vol.99 , pp. 112-121
    • Medrihan, L.1    Tantalaki, E.2    Aramuni, G.3    Sargsyan, V.4    Dudanova, I.5    Missler, M.6
  • 190
    • 84857434829 scopus 로고    scopus 로고
    • Genomics, intellectual disability and autism
    • Mefford, H. C., Batshaw, M. L., and Hoffman, E. P. (2012). Genomics, intellectual disability and autism. N. Engl. J. Med. 366, 733-743. doi: 10.1056/NEJMra1114194.
    • (2012) N. Engl. J. Med. , vol.366 , pp. 733-743
    • Mefford, H.C.1    Batshaw, M.L.2    Hoffman, E.P.3
  • 191
    • 80051961148 scopus 로고    scopus 로고
    • Oxytocin and vasopressin in the human brain: Social neuropeptides for translational medicine
    • Meyer-Lindenberg, A., Domes, G., Kirsch, P., and Heinrichs, M. (2011). Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. Nat. Rev. Neurosci. 12, 524-538. doi: 10.1038/nrn3044.
    • (2011) Nat. Rev. Neurosci. , vol.12 , pp. 524-538
    • Meyer-Lindenberg, A.1    Domes, G.2    Kirsch, P.3    Heinrichs, M.4
  • 192
    • 84891614268 scopus 로고    scopus 로고
    • Chronic metabotropic glutamate receptor 5 inhibition corrects local alterations of brain activity and improves cognitive performance in fragile X mice
    • Michalon, A., Bruns, A., Risterucci, C., Honer, M., Ballard, T. M., Ozmen, L., et al. (2014). Chronic metabotropic glutamate receptor 5 inhibition corrects local alterations of brain activity and improves cognitive performance in fragile X mice. Biol. Psychiatry 75, 189-197. doi: 10.1016/j.biopsych.2013.05.038.
    • (2014) Biol. Psychiatry , vol.75 , pp. 189-197
    • Michalon, A.1    Bruns, A.2    Risterucci, C.3    Honer, M.4    Ballard, T.M.5    Ozmen, L.6
  • 193
    • 84859628864 scopus 로고    scopus 로고
    • Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice
    • Michalon, A., Sidorov, M., Ballard, T. M., Ozmen, L., Spooren, W., Wettstein, J. G., et al. (2012). Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice. Neuron 74, 49-56. doi: 10.1016/j.neuron.2012.03.009.
    • (2012) Neuron , vol.74 , pp. 49-56
    • Michalon, A.1    Sidorov, M.2    Ballard, T.M.3    Ozmen, L.4    Spooren, W.5    Wettstein, J.G.6
  • 194
    • 58849126410 scopus 로고    scopus 로고
    • Elevated glycogen synthase kinase-3 activity in fragile X mice: Key metabolic regulator with evidence for treatment potential
    • Min, W. W., Yuskaitis, C. J., Yan, Q., Sikorski, C., Chen, S., Jope, R. S., et al. (2009). Elevated glycogen synthase kinase-3 activity in fragile X mice: key metabolic regulator with evidence for treatment potential.Neuropharmacology 56, 463-472. doi: 10.1016/j.neuropharm.2008.09.017.
    • (2009) Neuropharmacology , vol.56 , pp. 463-472
    • Min, W.W.1    Yuskaitis, C.J.2    Yan, Q.3    Sikorski, C.4    Chen, S.5    Jope, R.S.6
  • 195
    • 84859304559 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3: A promising therapeutic target for fragile x syndrome
    • Mines, M. A., and Jope, R. S. (2011). Glycogen synthase kinase-3: a promising therapeutic target for fragile x syndrome. Front. Mol. Neurosci. 4:35. doi: 10.3389/fnmol.2011.00035.
    • (2011) Front. Mol. Neurosci. , vol.4 , pp. 35
    • Mines, M.A.1    Jope, R.S.2
  • 196
    • 77956650465 scopus 로고    scopus 로고
    • GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of fragile X syndrome and autism
    • Mines, M. A., Yuskaitis, C. J., King, M. K., Beurel, E., and Jope, R. S. (2010). GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of fragile X syndrome and autism. PLoS One5:e9706. doi: 10.1371/journal.pone.0009706.
    • (2010) PLoS One , vol.5
    • Mines, M.A.1    Yuskaitis, C.J.2    King, M.K.3    Beurel, E.4    Jope, R.S.5
  • 197
    • 77949560003 scopus 로고    scopus 로고
    • Homeostatic regulation of neuronal excitability by K(+) channels in normal and diseased brains
    • Misonou, H. (2010). Homeostatic regulation of neuronal excitability by K(+) channels in normal and diseased brains. Neuroscientist 16, 51-64. doi: 10.1177/1073858409341085.
    • (2010) Neuroscientist , vol.16 , pp. 51-64
    • Misonou, H.1
  • 198
    • 33646683567 scopus 로고    scopus 로고
    • MeCP2 dysfunction in Rett syndrome and related disorders
    • Moretti, P., and Zoghbi, H. Y. (2006). MeCP2 dysfunction in Rett syndrome and related disorders. Curr. Opin. Genet. Dev. 16, 276-281. doi: 10.1016/j.gde.2006.04.009.
    • (2006) Curr. Opin. Genet. Dev. , vol.16 , pp. 276-281
    • Moretti, P.1    Zoghbi, H.Y.2
  • 199
    • 84872167553 scopus 로고    scopus 로고
    • Role of metabotropic glutamate receptors in persistent forms of hippocampal plasticity and learning
    • Mukherjee, S., and Manahan-Vaughan, D. (2013). Role of metabotropic glutamate receptors in persistent forms of hippocampal plasticity and learning. Neuropharmacology 66, 65-81. doi: 10.1016/j.neuropharm.2012.06.005.
    • (2013) Neuropharmacology , vol.66 , pp. 65-81
    • Mukherjee, S.1    Manahan-Vaughan, D.2
  • 200
    • 84874845902 scopus 로고    scopus 로고
    • Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway
    • Murata, Y., and Constantine-Paton, M. (2013). Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway. J. Neurosci. 33, 5040-5052. doi: 10.1523/jneurosci.2896-12.2013.
    • (2013) J. Neurosci. , vol.33 , pp. 5040-5052
    • Murata, Y.1    Constantine-Paton, M.2
  • 201
    • 84879883914 scopus 로고    scopus 로고
    • Recent developments in the genetics of autism spectrum disorders
    • Murdoch, J. D., and State, M. W. (2013). Recent developments in the genetics of autism spectrum disorders. Curr. Opin. Genet. Dev. 23, 310-315. doi: 10.1016/j.gde.2013.02.003.
    • (2013) Curr. Opin. Genet. Dev. , vol.23 , pp. 310-315
    • Murdoch, J.D.1    State, M.W.2
  • 202
    • 34848890329 scopus 로고    scopus 로고
    • Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors
    • Nakamoto, M., Nalavadi, V., Epstein, M. P., Narayanan, U., Bassell, G. J., and Warren, S. T. (2007). Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors. Proc. Natl. Acad. Sci. U S A 104, 15537-15542. doi: 10.1073/pnas.0707484104.
    • (2007) Proc. Natl. Acad. Sci. U S A , vol.104 , pp. 15537-15542
    • Nakamoto, M.1    Nalavadi, V.2    Epstein, M.P.3    Narayanan, U.4    Bassell, G.J.5    Warren, S.T.6
  • 203
    • 84878946078 scopus 로고    scopus 로고
    • The amyloid precursor protein: A biochemical enigma in brain development, function and disease
    • Nalivaeva, N. N., and Turner, A. J. (2013). The amyloid precursor protein: a biochemical enigma in brain development, function and disease. FEBS Lett. 587, 2046-2054. doi: 10.1016/j.febslet.2013.05.010.
    • (2013) FEBS Lett. , vol.587 , pp. 2046-2054
    • Nalivaeva, N.N.1    Turner, A.J.2
  • 204
    • 0032574977 scopus 로고    scopus 로고
    • Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
    • Nan, X., Ng, H. H., Johnson, C. A., Laherty, C. D., Turner, B. M., Eisenman, R. N., et al. (1998). Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393, 386-389. doi: 10.3410/f.718020287.793478774.
    • (1998) Nature , vol.393 , pp. 386-389
    • Nan, X.1    Ng, H.H.2    Johnson, C.A.3    Laherty, C.D.4    Turner, B.M.5    Eisenman, R.N.6
  • 205
    • 49649106751 scopus 로고    scopus 로고
    • S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade
    • Narayanan, U., Nalavadi, V., Nakamoto, M., Thomas, G., Ceman, S., Bassell, G. J., et al. (2008). S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade. J. Biol. Chem. 283, 18478-18482. doi: 10.1074/jbc.c800055200.
    • (2008) J. Biol. Chem. , vol.283 , pp. 18478-18482
    • Narayanan, U.1    Nalavadi, V.2    Nakamoto, M.3    Thomas, G.4    Ceman, S.5    Bassell, G.J.6
  • 207
    • 84952877388 scopus 로고    scopus 로고
    • Developmental delay in Rett syndrome: Data from the natural history study
    • Neul, J. L., Lane, J. B., Lee, H. S., Geerts, S., Barrish, J. O., Annese, F., et al. (2014). Developmental delay in Rett syndrome: data from the natural history study. J. Neurodev. Disord. 6:20. doi: 10.1186/1866-1955-6-20.
    • (2014) J. Neurodev. Disord. , vol.6 , pp. 20
    • Neul, J.L.1    Lane, J.B.2    Lee, H.S.3    Geerts, S.4    Barrish, J.O.5    Annese, F.6
  • 208
    • 45549103898 scopus 로고    scopus 로고
    • Brain oxytocin: A key regulator of emotional and social behaviours in both females and males
    • Neumann, I. D. (2008). Brain oxytocin: a key regulator of emotional and social behaviours in both females and males. J. Neuroendocrinol. 20, 858-865. doi: 10.1111/j.1365-2826.2008.01726.x.
    • (2008) J. Neuroendocrinol. , vol.20 , pp. 858-865
    • Neumann, I.D.1
  • 209
    • 84867916378 scopus 로고    scopus 로고
    • Balance of brain oxytocin and vasopressin: Implications for anxiety, depression and social behaviors
    • Neumann, I. D., and Landgraf, R. (2012). Balance of brain oxytocin and vasopressin: implications for anxiety, depression and social behaviors. Trends Neurosci. 35, 649-659. doi: 10.1016/j.tins.2012.08.004.
    • (2012) Trends Neurosci. , vol.35 , pp. 649-659
    • Neumann, I.D.1    Landgraf, R.2
  • 210
    • 34248589702 scopus 로고    scopus 로고
    • Glutamate antagonists seem to be slightly effective in psychopharmacologic treatment of autism
    • Niederhofer, H. (2007). Glutamate antagonists seem to be slightly effective in psychopharmacologic treatment of autism. J. Clin. Psychopharmacol. 27, 317-318. doi: 10.1097/01.jcp.0000270082.30500.69.
    • (2007) J. Clin. Psychopharmacol. , vol.27 , pp. 317-318
    • Niederhofer, H.1
  • 211
    • 35148840586 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome
    • Ogier, M., Wang, H., Hong, E., Wang, Q., Greenberg, M. E., and Katz, D. M. (2007). Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome.J. Neurosci. 27, 10912-10917. doi: 10.1523/jneurosci.1869-07.2007.
    • (2007) J. Neurosci. , vol.27 , pp. 10912-10917
    • Ogier, M.1    Wang, H.2    Hong, E.3    Wang, Q.4    Greenberg, M.E.5    Katz, D.M.6
  • 212
    • 83055184199 scopus 로고    scopus 로고
    • The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome
    • Olmos-Serrano, J. L., Corbin, J. G., and Burns, M. P. (2011). The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome. Dev. Neurosci. 33, 395-403. doi: 10.1159/000332884.
    • (2011) Dev. Neurosci. , vol.33 , pp. 395-403
    • Olmos-Serrano, J.L.1    Corbin, J.G.2    Burns, M.P.3
  • 213
    • 77954851827 scopus 로고    scopus 로고
    • Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome
    • Olmos-Serrano, J. L., Paluszkiewicz, S. M., Martin, B. S., Kaufmann, W. E., Corbin, J. G., and Huntsman, M. M. (2010). Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome. J. Neurosci. 30, 9929-9938. doi: 10.1523/jneurosci.1714-10.2010.
    • (2010) J. Neurosci. , vol.30 , pp. 9929-9938
    • Olmos-Serrano, J.L.1    Paluszkiewicz, S.M.2    Martin, B.S.3    Kaufmann, W.E.4    Corbin, J.G.5    Huntsman, M.M.6
  • 215
    • 34249098796 scopus 로고    scopus 로고
    • AMPA receptor potentiators: Application for depression and Parkinson’s disease
    • O’Neill, M. J., and Witkin, J. M. (2007). AMPA receptor potentiators: application for depression and Parkinson’s disease. Curr. Drug Targets 8, 603-620. doi: 10.2174/138945007780618517.
    • (2007) Curr. Drug Targets , vol.8 , pp. 603-620
    • O’Neill, M.J.1    Witkin, J.M.2
  • 216
    • 84872716739 scopus 로고    scopus 로고
    • Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome
    • Osterweil, E. K., Chuang, S. C., Chubykin, A. A., Sidorov, M., Bianchi, R., Wong, R. K., et al. (2013). Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome. Neuron77, 243-250. doi: 10.1016/j.neuron.2012.01.034.
    • (2013) Neuron , vol.77 , pp. 243-250
    • Osterweil, E.K.1    Chuang, S.C.2    Chubykin, A.A.3    Sidorov, M.4    Bianchi, R.5    Wong, R.K.6
  • 217
    • 78449259794 scopus 로고    scopus 로고
    • Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome
    • Osterweil, E. K., Krueger, D. D., Reinhold, K., and Bear, M. F. (2010). Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome. J. Neurosci. 30, 15616-15627. doi: 10.1523/jneurosci.3888-10.2010.
    • (2010) J. Neurosci. , vol.30 , pp. 15616-15627
    • Osterweil, E.K.1    Krueger, D.D.2    Reinhold, K.3    Bear, M.F.4
  • 218
    • 81855185433 scopus 로고    scopus 로고
    • DAGL-dependent endocannabinoid signalling: Roles in axonal pathfinding, synaptic plasticity and adult neurogenesis
    • Oudin, M. J., Hobbs, C., and Doherty, P. (2011). DAGL-dependent endocannabinoid signalling: roles in axonal pathfinding, synaptic plasticity and adult neurogenesis. Eur. J. Neurosci. 34, 1634-1646. doi: 10.1111/j.1460-9568.2011.07831.x.
    • (2011) Eur. J. Neurosci. , vol.34 , pp. 1634-1646
    • Oudin, M.J.1    Hobbs, C.2    Doherty, P.3
  • 219
    • 35048886071 scopus 로고    scopus 로고
    • Developmental expression of FMRP in the astrocyte lineage: Implications for fragile X syndrome
    • Pacey, L. K., and Doering, L. C. (2007). Developmental expression of FMRP in the astrocyte lineage: implications for fragile X syndrome. Glia 55, 1601-1609. doi: 10.1002/glia.20573.
    • (2007) Glia , vol.55 , pp. 1601-1609
    • Pacey, L.K.1    Doering, L.C.2
  • 220
    • 67649834454 scopus 로고    scopus 로고
    • Increased GABA(B) receptor-mediated signaling reduces the susceptibility of fragile X knockout mice to audiogenic seizures
    • Pacey, L. K., Heximer, S. P., and Hampson, D. R. (2009). Increased GABA(B) receptor-mediated signaling reduces the susceptibility of fragile X knockout mice to audiogenic seizures. Mol. Pharmacol. 76, 18-24. doi: 10.1124/mol.109.056127.
    • (2009) Mol. Pharmacol. , vol.76 , pp. 18-24
    • Pacey, L.K.1    Heximer, S.P.2    Hampson, D.R.3
  • 221
    • 80052166631 scopus 로고    scopus 로고
    • Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome
    • Pacey, L. K., Tharmalingam, S., and Hampson, D. R. (2011). Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome. J. Pharmacol. Exp. Ther. 338, 897-905. doi: 10.1124/jpet.111.183327.
    • (2011) J. Pharmacol. Exp. Ther. , vol.338 , pp. 897-905
    • Pacey, L.K.1    Tharmalingam, S.2    Hampson, D.R.3
  • 222
    • 83055163327 scopus 로고    scopus 로고
    • Fragile X syndrome: The GABAergic system and circuit dysfunction
    • Paluszkiewicz, S. M., Martin, B. S., and Huntsman, M. M. (2011). Fragile X syndrome: the GABAergic system and circuit dysfunction. Dev. Neurosci. 33, 349-364. doi: 10.1159/000329420.
    • (2011) Dev. Neurosci. , vol.33 , pp. 349-364
    • Paluszkiewicz, S.M.1    Martin, B.S.2    Huntsman, M.M.3
  • 223
    • 77957678816 scopus 로고    scopus 로고
    • Open-label add-on treatment trial of minocycline in fragile X syndrome
    • Paribello, C., Tao, L., Folino, A., Berry-Kravis, E., Tranfaglia, M., Ethell, I. M., et al. (2010). Open-label add-on treatment trial of minocycline in fragile X syndrome. BMC Neurol. 10:91. doi: 10.1186/1471-2377-10-91.
    • (2010) BMC Neurol. , vol.10 , pp. 91
    • Paribello, C.1    Tao, L.2    Folino, A.3    Berry-Kravis, E.4    Tranfaglia, M.5    Ethell, I.M.6
  • 224
    • 84873739255 scopus 로고    scopus 로고
    • Dampened dopamine-mediated neuromodulation in prefrontal cortex of fragile X mice
    • Paul, K., Venkitaramani, D. V., and Cox, C. L. (2013). Dampened dopamine-mediated neuromodulation in prefrontal cortex of fragile X mice. J. Physiol. 591, 1133-1143. doi: 10.1113/jphysiol.2012.241067.
    • (2013) J. Physiol. , vol.591 , pp. 1133-1143
    • Paul, K.1    Venkitaramani, D.V.2    Cox, C.L.3
  • 227
    • 78650914440 scopus 로고    scopus 로고
    • Rett syndrome diagnostic criteria: Lessons from the natural history study
    • Percy, A. K., Neul, J. L., Glaze, D. G., Motil, K. J., Skinner, S. A., Khwaja, O., et al. (2010). Rett syndrome diagnostic criteria: lessons from the natural history study. Ann. Neurol. 68, 951-955. doi: 10.1002/ana.22154.
    • (2010) Ann. Neurol. , vol.68 , pp. 951-955
    • Percy, A.K.1    Neul, J.L.2    Glaze, D.G.3    Motil, K.J.4    Skinner, S.A.5    Khwaja, O.6
  • 228
    • 84867127593 scopus 로고    scopus 로고
    • Acetylcholine as a neuromodulator: Cholinergic signaling shapes nervous system function and behavior
    • Picciotto, M. R., Higley, M. J., and Mineur, Y. S. (2012). Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior. Neuron 76, 116-129. doi: 10.1016/j.neuron.2012.08.036.
    • (2012) Neuron , vol.76 , pp. 116-129
    • Picciotto, M.R.1    Higley, M.J.2    Mineur, Y.S.3
  • 229
    • 60349108540 scopus 로고    scopus 로고
    • Synaptic ionotropic glutamate receptors and plasticity are developmentally altered in the CA1 field of Fmr1 knockout mice
    • Pilpel, Y., Kolleker, A., Berberich, S., Ginger, M., Frick, A., Mientjes, E., et al. (2009). Synaptic ionotropic glutamate receptors and plasticity are developmentally altered in the CA1 field of Fmr1 knockout mice. J. Physiol. 587, 787-804. doi: 10.1113/jphysiol.2008.160929.
    • (2009) J. Physiol. , vol.587 , pp. 787-804
    • Pilpel, Y.1    Kolleker, A.2    Berberich, S.3    Ginger, M.4    Frick, A.5    Mientjes, E.6
  • 230
    • 84878912163 scopus 로고    scopus 로고
    • Insulinotropic treatments exacerbate metabolic syndrome in mice lacking MeCP2 function
    • Pitcher, M. R., Ward, C. S., Arvide, E. M., Chapleau, C. A., Pozzo-Miller, L., Hoeflich, A., et al. (2013). Insulinotropic treatments exacerbate metabolic syndrome in mice lacking MeCP2 function. Hum. Mol. Genet. 22, 2626-2633. doi: 10.1093/hmg/ddt111.
    • (2013) Hum. Mol. Genet. , vol.22 , pp. 2626-2633
    • Pitcher, M.R.1    Ward, C.S.2    Arvide, E.M.3    Chapleau, C.A.4    Pozzo-Miller, L.5    Hoeflich, A.6
  • 231
    • 84896713573 scopus 로고    scopus 로고
    • Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant
    • Pop, A. S., Levenga, J., de Esch, C. E., Buijsen, R. A., Nieuwenhuizen, I. M., Li, T., et al. (2014). Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant. Psychopharmacology (Berl)231, 1227-1235. doi: 10.1007/s00213-012-2947-y.
    • (2014) Psychopharmacology (Berl) , vol.231 , pp. 1227-1235
    • Pop, A.S.1    Levenga, J.2    de Esch, C.E.3    Buijsen, R.A.4    Nieuwenhuizen, I.M.5    Li, T.6
  • 232
    • 77955392133 scopus 로고    scopus 로고
    • Aminoglycoside-mediated partial suppression of MECP2 nonsense mutations responsible for Rett syndrome in vitro
    • Popescu, A. C., Sidorova, E., Zhang, G., and Eubanks, J. H. (2010). Aminoglycoside-mediated partial suppression of MECP2 nonsense mutations responsible for Rett syndrome in vitro. J. Neurosci. Res. 88, 2316-2324. doi: 10.1002/jnr.22409.
    • (2010) J. Neurosci. Res. , vol.88 , pp. 2316-2324
    • Popescu, A.C.1    Sidorova, E.2    Zhang, G.3    Eubanks, J.H.4
  • 235
    • 77955089126 scopus 로고    scopus 로고
    • The functional neurophysiology of the amyloid precursor protein (APP) processing pathway
    • Randall, A. D., Witton, J., Booth, C., Hynes-Allen, A., and Brown, J. T. (2010). The functional neurophysiology of the amyloid precursor protein (APP) processing pathway. Neuropharmacology 59, 243-267. doi: 10.1016/j.neuropharm.2010.02.011.
    • (2010) Neuropharmacology , vol.59 , pp. 243-267
    • Randall, A.D.1    Witton, J.2    Booth, C.3    Hynes-Allen, A.4    Brown, J.T.5
  • 236
    • 0034143238 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors trigger homosynaptic protein synthesis to prolong long-term potentiation
    • Raymond, C. R., Thompson, V. L., Tate, W. P., and Abraham, W. C. (2000). Metabotropic glutamate receptors trigger homosynaptic protein synthesis to prolong long-term potentiation. J. Neurosci. 20, 969-976..
    • (2000) J. Neurosci. , vol.20 , pp. 969-976
    • Raymond, C.R.1    Thompson, V.L.2    Tate, W.P.3    Abraham, W.C.4
  • 237
    • 24044449245 scopus 로고    scopus 로고
    • Blink rate in boys with fragile X syndrome: Preliminary evidence for altered dopamine function
    • Roberts, J. E., Symons, F. J., Johnson, A. M., Hatton, D. D., and Boccia, M. L. (2005). Blink rate in boys with fragile X syndrome: preliminary evidence for altered dopamine function. J. Intellect. Disabil. Res. 49, 647-656. doi: 10.1111/j.1365-2788.2005.00713.x.
    • (2005) J. Intellect. Disabil. Res. , vol.49 , pp. 647-656
    • Roberts, J.E.1    Symons, F.J.2    Johnson, A.M.3    Hatton, D.D.4    Boccia, M.L.5
  • 238
    • 84892366098 scopus 로고    scopus 로고
    • Reorganization of circuits underlying cerebellar modulation of prefrontal cortical dopamine in mouse models of autism spectrum disorder
    • Rogers, T. D., Dickson, P. E., McKimm, E., Heck, D. H., Goldowitz, D., Blaha, C. D., et al. (2013). Reorganization of circuits underlying cerebellar modulation of prefrontal cortical dopamine in mouse models of autism spectrum disorder. Cerebellum 12, 547-556. doi: 10.1007/s12311-013-0462-2.
    • (2013) Cerebellum , vol.12 , pp. 547-556
    • Rogers, T.D.1    Dickson, P.E.2    McKimm, E.3    Heck, D.H.4    Goldowitz, D.5    Blaha, C.D.6
  • 239
    • 84892799819 scopus 로고    scopus 로고
    • The role of de novo mutations in the genetics of autism spectrum disorders
    • Ronemus, M., Iossifov, I., Levy, D., and Wigler, M. (2014). The role of de novo mutations in the genetics of autism spectrum disorders. Nat. Rev. Genet. 15, 133-141. doi: 10.1038/nrg3585.
    • (2014) Nat. Rev. Genet. , vol.15 , pp. 133-141
    • Ronemus, M.1    Iossifov, I.2    Levy, D.3    Wigler, M.4
  • 240
    • 45149122378 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors and fragile x mental retardation protein: Partners in translational regulation at the synapse
    • Ronesi, J. A., and Huber, K. M. (2008a). Metabotropic glutamate receptors and fragile x mental retardation protein: partners in translational regulation at the synapse. Sci. Signal. 1:pe6. doi: 10.1126/stke.15pe6.
    • (2008) Sci. Signal. , vol.1
    • Ronesi, J.A.1    Huber, K.M.2
  • 241
    • 38349029199 scopus 로고    scopus 로고
    • Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation
    • Ronesi, J. A., and Huber, K. M. (2008b). Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation. J. Neurosci. 28, 543-547. doi: 10.1523/jneurosci.5019-07.2008.
    • (2008) J. Neurosci. , vol.28 , pp. 543-547
    • Ronesi, J.A.1    Huber, K.M.2
  • 242
    • 84856596122 scopus 로고    scopus 로고
    • Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of Fragile X syndrome
    • Rotschafer, S. E., Trujillo, M. S., Dansie, L. E., Ethell, I. M., and Razak, K. A. (2012). Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of Fragile X syndrome. Brain Res. 1439, 7-14. doi: 10.1016/j.brainres.2011.12.041.
    • (2012) Brain Res. , vol.1439 , pp. 7-14
    • Rotschafer, S.E.1    Trujillo, M.S.2    Dansie, L.E.3    Ethell, I.M.4    Razak, K.A.5
  • 243
    • 34147198993 scopus 로고    scopus 로고
    • Treatment with desipramine improves breathing and survival in a mouse model for Rett syndrome
    • Roux, J. C., Dura, E., Moncla, A., Mancini, J., and Villard, L. (2007). Treatment with desipramine improves breathing and survival in a mouse model for Rett syndrome. Eur. J. Neurosci. 25, 1915-1922. doi: 10.1111/j.1460-9568.2007.05466.x.
    • (2007) Eur. J. Neurosci. , vol.25 , pp. 1915-1922
    • Roux, J.C.1    Dura, E.2    Moncla, A.3    Mancini, J.4    Villard, L.5
  • 244
    • 54249106325 scopus 로고    scopus 로고
    • Tyrosine hydroxylase deficit in the chemoafferent and the sympathoadrenergic pathways of the Mecp2 deficient mouse
    • Roux, J. C., Dura, E., and Villard, L. (2008). Tyrosine hydroxylase deficit in the chemoafferent and the sympathoadrenergic pathways of the Mecp2 deficient mouse. Neurosci. Lett. 447, 82-86. doi: 10.1016/j.neulet.2008.09.045.
    • (2008) Neurosci. Lett. , vol.447 , pp. 82-86
    • Roux, J.C.1    Dura, E.2    Villard, L.3
  • 245
    • 79958025812 scopus 로고    scopus 로고
    • Complexities of Rett syndrome and MeCP2
    • Samaco, R. C., and Neul, J. L. (2011). Complexities of Rett syndrome and MeCP2. J. Neurosci. 31, 7951-7959. doi: 10.1523/jneurosci.0169-11.2011.
    • (2011) J. Neurosci. , vol.31 , pp. 7951-7959
    • Samaco, R.C.1    Neul, J.L.2
  • 246
    • 84856879093 scopus 로고    scopus 로고
    • Molecular mechanisms of fragile X syndrome: A twenty-year perspective
    • Santoro, M. R., Bray, S. M., and Warren, S. T. (2012). Molecular mechanisms of fragile X syndrome: a twenty-year perspective. Annu. Rev. Pathol. 7, 219-245. doi: 10.1146/annurev-pathol-011811-132457.
    • (2012) Annu. Rev. Pathol. , vol.7 , pp. 219-245
    • Santoro, M.R.1    Bray, S.M.2    Warren, S.T.3
  • 247
    • 1842429102 scopus 로고    scopus 로고
    • Phenotypic manifestations of MECP2 mutations in classical and atypical Rett syndrome
    • Schanen, C., Houwink, E. J., Dorrani, N., Lane, J., Everett, R., Feng, A., et al. (2004). Phenotypic manifestations of MECP2 mutations in classical and atypical Rett syndrome. Am. J. Med. Genet. A 126A, 129-140. doi: 10.1002/ajmg.a.20571.
    • (2004) Am. J. Med. Genet. A , vol.126A , pp. 129-140
    • Schanen, C.1    Houwink, E.J.2    Dorrani, N.3    Lane, J.4    Everett, R.5    Feng, A.6
  • 248
    • 84904464077 scopus 로고    scopus 로고
    • An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits
    • Scheele, D., Kendrick, K. M., Khouri, C., Kretzer, E., Schläpfer, T. E., Stoffel-Wagner, B., et al. (2014). An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits.Neuropsychopharmacology 39, 2078-2085. doi: 10.1038/npp.2014.78.
    • (2014) Neuropsychopharmacology , vol.39 , pp. 2078-2085
    • Scheele, D.1    Kendrick, K.M.2    Khouri, C.3    Kretzer, E.4    Schläpfer, T.E.5    Stoffel-Wagner, B.6
  • 249
    • 84863025204 scopus 로고    scopus 로고
    • A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome
    • Schmid, D. A., Yang, T., Ogier, M., Adams, I., Mirakhur, Y., Wang, Q., et al. (2012). A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome. J. Neurosci. 32, 1803-1810. doi: 10.1523/JNEUROSCI.0865-11.2012.
    • (2012) J. Neurosci. , vol.32 , pp. 1803-1810
    • Schmid, D.A.1    Yang, T.2    Ogier, M.3    Adams, I.4    Mirakhur, Y.5    Wang, Q.6
  • 250
    • 84890122852 scopus 로고    scopus 로고
    • c-Jun N-terminal kinase regulates mGluR-dependent expression of post-synaptic FMRP target proteins
    • Schmit, T. L., Dowell, J. A., Maes, M. E., and Wilhelm, M. (2013). c-Jun N-terminal kinase regulates mGluR-dependent expression of post-synaptic FMRP target proteins. J. Neurochem. 127, 772-781. doi: 10.1111/jnc.12453.
    • (2013) J. Neurochem. , vol.127 , pp. 772-781
    • Schmit, T.L.1    Dowell, J.A.2    Maes, M.E.3    Wilhelm, M.4
  • 251
    • 0742304657 scopus 로고    scopus 로고
    • The principal features and mechanisms of dopamine modulation in the prefrontal cortex
    • Seamans, J. K., and Yang, C. R. (2004). The principal features and mechanisms of dopamine modulation in the prefrontal cortex. Prog. Neurobiol. 74, 1-58. doi: 10.1016/j.pneurobio.2004.05.006.
    • (2004) Prog. Neurobiol. , vol.74 , pp. 1-58
    • Seamans, J.K.1    Yang, C.R.2
  • 252
    • 0029925683 scopus 로고    scopus 로고
    • Intracellular signaling pathways activated by neurotrophic factors
    • Segal, R. A., and Greenberg, M. E. (1996). Intracellular signaling pathways activated by neurotrophic factors. Annu. Rev. Neurosci. 19, 463-489. doi: 10.1146/annurev.neuro.19.1.463.
    • (1996) Annu. Rev. Neurosci. , vol.19 , pp. 463-489
    • Segal, R.A.1    Greenberg, M.E.2
  • 253
    • 0037081840 scopus 로고    scopus 로고
    • Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation
    • Shahbazian, M. D., Antalffy, B., Armstrong, D. L., and Zoghbi, H. Y. (2002). Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation. Hum. Mol. Genet. 11, 115-124. doi: 10.1093/hmg/11.2.115.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 115-124
    • Shahbazian, M.D.1    Antalffy, B.2    Armstrong, D.L.3    Zoghbi, H.Y.4
  • 255
    • 84904554983 scopus 로고    scopus 로고
    • Genetic removal of matrix metalloproteinase 9 rescues the symptoms of fragile x syndrome in a mouse model
    • Sidhu, H., Dansie, L. E., Hickmott, P. W., Ethell, D. W., and Ethell, I. M. (2014). Genetic removal of matrix metalloproteinase 9 rescues the symptoms of fragile x syndrome in a mouse model. J. Neurosci. 34, 9867-9879. doi: 10.1523/jneurosci.1162-14.2014.
    • (2014) J. Neurosci. , vol.34 , pp. 9867-9879
    • Sidhu, H.1    Dansie, L.E.2    Hickmott, P.W.3    Ethell, D.W.4    Ethell, I.M.5
  • 256
    • 84875850679 scopus 로고    scopus 로고
    • Fragile X mental retardation protein and synaptic plasticity
    • Sidorov, M. S., Auerbach, B. D., and Bear, M. F. (2013). Fragile X mental retardation protein and synaptic plasticity.Mol. Brain 6:15. doi: 10.1186/1756-6606-6-15.
    • (2013) Mol. Brain , vol.6 , pp. 15
    • Sidorov, M.S.1    Auerbach, B.D.2    Bear, M.F.3
  • 257
    • 84869992899 scopus 로고    scopus 로고
    • Structure, function and modulation of GABA(A) receptors
    • Sigel, E., and Steinmann, M. E. (2012). Structure, function and modulation of GABA(A) receptors. J. Biol. Chem.287, 40224-40231. doi: 10.1074/jbc.R112.386664.
    • (2012) J. Biol. Chem. , vol.287 , pp. 40224-40231
    • Sigel, E.1    Steinmann, M.E.2
  • 258
    • 84862336959 scopus 로고    scopus 로고
    • Matrix metalloproteinases and minocycline: Therapeutic avenues for fragile X syndrome
    • Siller, S. S., and Broadie, K. (2012). Matrix metalloproteinases and minocycline: therapeutic avenues for fragile X syndrome. Neural Plast. 2012:124548. doi: 10.1155/2012/124548.
    • (2012) Neural Plast. , vol.2012
    • Siller, S.S.1    Broadie, K.2
  • 259
    • 84877012162 scopus 로고    scopus 로고
    • Fmr1 deletion enhances and ultimately desensitizes CB(1) signaling in autaptic hippocampal neurons
    • Straiker, A., Min, K. T., and Mackie, K. (2013). Fmr1 deletion enhances and ultimately desensitizes CB(1) signaling in autaptic hippocampal neurons. Neurobiol. Dis. 56, 1-5. doi: 10.1016/j.nbd.2013.04.002.
    • (2013) Neurobiol. Dis. , vol.56 , pp. 1-5
    • Straiker, A.1    Min, K.T.2    McKie, K.3
  • 260
    • 77955393170 scopus 로고    scopus 로고
    • Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b
    • Strumbos, J. G., Brown, M. R., Kronengold, J., Polley, D. B., and Kaczmarek, L. K. (2010). Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b. J. Neurosci. 30, 10263-10271. doi: 10.1523/jneurosci.1125-10.2010.
    • (2010) J. Neurosci. , vol.30 , pp. 10263-10271
    • Strumbos, J.G.1    Brown, M.R.2    Kronengold, J.3    Polley, D.B.4    Kaczmarek, L.K.5
  • 261
    • 40349098058 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 (GSK3) in the heart: A point of integration in hypertrophic signalling and a therapeutic target? A critical analysis
    • Sugden, P. H., Fuller, S. J., Weiss, S. C., and Clerk, A. (2008). Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis. Br. J. Pharmacol. 153(Suppl 1), S137-S153. doi: 10.1038/sj.bjp.0707659.
    • (2008) Br. J. Pharmacol. , vol.153 , pp. S137-S153
    • Sugden, P.H.1    Fuller, S.J.2    Weiss, S.C.3    Clerk, A.4
  • 262
    • 72549103697 scopus 로고    scopus 로고
    • Dopamine and synaptic plasticity in dorsal striatal circuits controlling action selection
    • Surmeier, D. J., Plotkin, J., and Shen, W. (2009). Dopamine and synaptic plasticity in dorsal striatal circuits controlling action selection. Curr. Opin. Neurobiol. 19, 621-628. doi: 10.1016/j.conb.2009.10.003.
    • (2009) Curr. Opin. Neurobiol. , vol.19 , pp. 621-628
    • Surmeier, D.J.1    Plotkin, J.2    Shen, W.3
  • 263
    • 77954858360 scopus 로고    scopus 로고
    • Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome
    • Suvrathan, A., Hoeffer, C. A., Wong, H., Klann, E., and Chattarji, S. (2010). Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome. Proc. Natl. Acad. Sci. U S A 107, 11591-11596. doi: 10.1073/pnas.1002262107.
    • (2010) Proc. Natl. Acad. Sci. U S A , vol.107 , pp. 11591-11596
    • Suvrathan, A.1    Hoeffer, C.A.2    Wong, H.3    Klann, E.4    Chattarji, S.5
  • 264
    • 68049129281 scopus 로고    scopus 로고
    • Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes
    • Tavoulari, S., Forrest, L. R., and Rudnick, G. (2009). Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes. J. Neurosci. 29, 9635-9643. doi: 10.1523/jneurosci.0440-09.2009.
    • (2009) J. Neurosci. , vol.29 , pp. 9635-9643
    • Tavoulari, S.1    Forrest, L.R.2    Rudnick, G.3
  • 265
    • 80053924976 scopus 로고    scopus 로고
    • Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome
    • Thomas, A. M., Bui, N., Graham, D., Perkins, J. R., Yuva-Paylor, L. A., and Paylor, R. (2011). Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome. Behav. Brain Res. 223, 310-321. doi: 10.1016/j.bbr.2011.04.049.
    • (2011) Behav. Brain Res. , vol.223 , pp. 310-321
    • Thomas, A.M.1    Bui, N.2    Graham, D.3    Perkins, J.R.4    Yuva-Paylor, L.A.5    Paylor, R.6
  • 266
    • 84856639776 scopus 로고    scopus 로고
    • Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome
    • Thomas, A. M., Bui, N., Perkins, J. R., Yuva-Paylor, L. A., and Paylor, R. (2012). Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome. Psychopharmacology (Berl)219, 47-58. doi: 10.1007/s00213-011-2375-4.
    • (2012) Psychopharmacology (Berl) , vol.219 , pp. 47-58
    • Thomas, A.M.1    Bui, N.2    Perkins, J.R.3    Yuva-Paylor, L.A.4    Paylor, R.5
  • 267
    • 1342289413 scopus 로고    scopus 로고
    • MAPK cascade signalling and synaptic plasticity
    • Thomas, G. M., and Huganir, R. L. (2004). MAPK cascade signalling and synaptic plasticity. Nat. Rev. Neurosci. 5, 173-183. doi: 10.1038/nrn1346.
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 173-183
    • Thomas, G.M.1    Huganir, R.L.2
  • 268
    • 0035013739 scopus 로고    scopus 로고
    • MECP2 mutations in sporadic cases of Rett syndrome are almost exclusively of paternal origin
    • Trappe, R., Laccone, F., Cobilanschi, J., Meins, M., Huppke, P., Hanefeld, F., et al. (2001). MECP2 mutations in sporadic cases of Rett syndrome are almost exclusively of paternal origin. Am. J. Hum. Genet. 68, 1093-1101. doi: 10.1086/320109.
    • (2001) Am. J. Hum. Genet. , vol.68 , pp. 1093-1101
    • Trappe, R.1    Laccone, F.2    Cobilanschi, J.3    Meins, M.4    Huppke, P.5    Hanefeld, F.6
  • 270
    • 84893640636 scopus 로고    scopus 로고
    • Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring
    • Tyzio, R., Nardou, R., Ferrari, D. C., Tsintsadze, T., Shahrokhi, A., Eftekhari, S., et al. (2014). Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring. Science 343, 675-679. doi: 10.1126/science.1247190.
    • (2014) Science , vol.343 , pp. 675-679
    • Tyzio, R.1    Nardou, R.2    Ferrari, D.C.3    Tsintsadze, T.4    Shahrokhi, A.5    Eftekhari, S.6
  • 271
    • 84872130293 scopus 로고    scopus 로고
    • Role of presynaptic metabotropic glutamate receptors in the induction of long-term synaptic plasticity of vesicular release
    • Upreti, C., Zhang, X. L., Alford, S., and Stanton, P. K. (2013). Role of presynaptic metabotropic glutamate receptors in the induction of long-term synaptic plasticity of vesicular release. Neuropharmacology 66, 31-39. doi: 10.1016/j.neuropharm.2012.05.004.
    • (2013) Neuropharmacology , vol.66 , pp. 31-39
    • Upreti, C.1    Zhang, X.L.2    Alford, S.3    Stanton, P.K.4
  • 272
    • 84901639525 scopus 로고    scopus 로고
    • Distinctive behavioral and cellular responses to fluoxetine in the mouse model for fragile X syndrome
    • Uutela, M., Lindholm, J., Rantamäki, T., Umemori, J., Hunter, K., Võikar, V., et al. (2014). Distinctive behavioral and cellular responses to fluoxetine in the mouse model for fragile X syndrome. Front. Cell. Neurosci. 8:150. doi: 10.3389/fncel.2014.00150.
    • (2014) Front. Cell. Neurosci. , vol.8 , pp. 150
    • Uutela, M.1    Lindholm, J.2    Rantamäki, T.3    Umemori, J.4    Hunter, K.5    Võikar, V.6
  • 273
    • 84859475819 scopus 로고    scopus 로고
    • Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior
    • Veenstra-VanderWeele, J., Muller, C. L., Iwamoto, H., Sauer, J. E., Owens, W. A., Shah, C. R., et al. (2012). Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior. Proc. Natl. Acad. Sci. U S A 109, 5469-5474. doi: 10.1073/pnas.1112345109.
    • (2012) Proc. Natl. Acad. Sci. U S A , vol.109 , pp. 5469-5474
    • Veenstra-VanderWeele, J.1    Muller, C.L.2    Iwamoto, H.3    Sauer, J.E.4    Owens, W.A.5    Shah, C.R.6
  • 274
    • 80053611552 scopus 로고    scopus 로고
    • Modulation of behavioral phenotypes by a muscarinic M1 antagonist in a mouse model of fragile X syndrome
    • Veeraragavan, S., Bui, N., Perkins, J. R., Yuva-Paylor, L. A., Carpenter, R. L., and Paylor, R. (2011b). Modulation of behavioral phenotypes by a muscarinic M1 antagonist in a mouse model of fragile X syndrome.Psychopharmacology (Berl) 217, 143-151. doi: 10.1007/s00213-011-2276-6.
    • (2011) Psychopharmacology (Berl) , vol.217 , pp. 143-151
    • Veeraragavan, S.1    Bui, N.2    Perkins, J.R.3    Yuva-Paylor, L.A.4    Carpenter, R.L.5    Paylor, R.6
  • 275
    • 80053607529 scopus 로고    scopus 로고
    • The modulation of fragile X behaviors by the muscarinic M4 antagonist, tropicamide
    • Veeraragavan, S., Bui, N., Perkins, J. R., Yuva-Paylor, L. A., and Paylor, R. (2011a). The modulation of fragile X behaviors by the muscarinic M4 antagonist, tropicamide. Behav. Neurosci. 125, 783-790. doi: 10.1037/a0025202.
    • (2011) Behav. Neurosci. , vol.125 , pp. 783-790
    • Veeraragavan, S.1    Bui, N.2    Perkins, J.R.3    Yuva-Paylor, L.A.4    Paylor, R.5
  • 276
    • 83655164085 scopus 로고    scopus 로고
    • Genetic reduction of muscarinic M4 receptor modulates analgesic response and acoustic startle response in a mouse model of fragile X syndrome (FXS)
    • Veeraragavan, S., Graham, D., Bui, N., Yuva-Paylor, L. A., Wess, J., and Paylor, R. (2012). Genetic reduction of muscarinic M4 receptor modulates analgesic response and acoustic startle response in a mouse model of fragile X syndrome (FXS). Behav. Brain Res. 228, 1-8. doi: 10.1016/j.bbr.2011.11.018.
    • (2012) Behav. Brain Res. , vol.228 , pp. 1-8
    • Veeraragavan, S.1    Graham, D.2    Bui, N.3    Yuva-Paylor, L.A.4    Wess, J.5    Paylor, R.6
  • 277
    • 84859420788 scopus 로고    scopus 로고
    • The effect of an mGluR5 inhibitor on procedural memory and avoidance discrimination impairments in Fmr1 KO mice
    • Vinueza Veloz, M. F., Buijsen, R. A., Willemsen, R., Cupido, A., Bosman, L. W., Koekkoek, S. K., et al. (2012). The effect of an mGluR5 inhibitor on procedural memory and avoidance discrimination impairments in Fmr1 KO mice.Genes Brain Behav. 11, 325-331. doi: 10.1111/j.1601-183x.2011.00763.x.
    • (2012) Genes Brain Behav. , vol.11 , pp. 325-331
    • Vinueza Veloz, M.F.1    Buijsen, R.A.2    Willemsen, R.3    Cupido, A.4    Bosman, L.W.5    Koekkoek, S.K.6
  • 278
    • 35548930804 scopus 로고    scopus 로고
    • Multiple Gq-coupled receptors converge on a common protein synthesis-dependent long-term depression that is affected in fragile X syndrome mental retardation
    • Volk, L. J., Pfeiffer, B. E., Gibson, J. R., and Huber, K. M. (2007). Multiple Gq-coupled receptors converge on a common protein synthesis-dependent long-term depression that is affected in fragile X syndrome mental retardation. J. Neurosci. 27, 11624-11634. doi: 10.1523/jneurosci.2266-07.2007.
    • (2007) J. Neurosci. , vol.27 , pp. 11624-11634
    • Volk, L.J.1    Pfeiffer, B.E.2    Gibson, J.R.3    Huber, K.M.4
  • 279
    • 0345304274 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptor subtypes in cerebral cortex and hippocampus
    • Volpicelli, L. A., and Levey, A. I. (2004). Muscarinic acetylcholine receptor subtypes in cerebral cortex and hippocampus. Prog. Brain Res. 145, 59-66. doi: 10.1016/s0079-6123(03)45003-6.
    • (2004) Prog. Brain Res. , vol.145 , pp. 59-66
    • Volpicelli, L.A.1    Levey, A.I.2
  • 280
    • 84897083203 scopus 로고    scopus 로고
    • Lipid rafts: A signaling platform linking cholesterol metabolism to synaptic deficits in autism spectrum disorders
    • Wang, H. (2014). Lipid rafts: a signaling platform linking cholesterol metabolism to synaptic deficits in autism spectrum disorders. Front. Behav. Neurosci. 8:104. doi: 10.3389/fnbeh.2014.00104.
    • (2014) Front. Behav. Neurosci. , vol.8 , pp. 104
    • Wang, H.1
  • 281
    • 77954915376 scopus 로고    scopus 로고
    • Fragile X: Leading the way for targeted treatments in autism
    • Wang, L. W., Berry-Kravis, E., and Hagerman, R. J. (2010b). Fragile X: leading the way for targeted treatments in autism. Neurotherapeutics 7, 264-274. doi: 10.1016/j.nurt.2010.05.005.
    • (2010) Neurotherapeutics , vol.7 , pp. 264-274
    • Wang, L.W.1    Berry-Kravis, E.2    Hagerman, R.J.3
  • 282
    • 84862803170 scopus 로고    scopus 로고
    • New perspectives on the biology of fragile X syndrome
    • Wang, T., Bray, S. M., and Warren, S. T. (2012a). New perspectives on the biology of fragile X syndrome. Curr. Opin. Genet. Dev. 22, 256-263. doi: 10.1016/j.gde.2012.02.002.
    • (2012) Curr. Opin. Genet. Dev. , vol.22 , pp. 256-263
    • Wang, T.1    Bray, S.M.2    Warren, S.T.3
  • 283
    • 84864929468 scopus 로고    scopus 로고
    • Induced pluripotent stem cells to model and treat neurogenetic disorders
    • Wang, H., and Doering, L. C. (2012). Induced pluripotent stem cells to model and treat neurogenetic disorders.Neural Plast. 2012:346053. doi: 10.1155/2012/346053.
    • (2012) Neural Plast. , vol.2012
    • Wang, H.1    Doering, L.C.2
  • 284
    • 84875921248 scopus 로고    scopus 로고
    • Reversing autism by targeting downstream mTOR signaling
    • Wang, H., and Doering, L. C. (2013). Reversing autism by targeting downstream mTOR signaling. Front. Cell. Neurosci. 7:28. doi: 10.3389/fncel.2013.00028.
    • (2013) Front. Cell. Neurosci. , vol.7 , pp. 28
    • Wang, H.1    Doering, L.C.2
  • 285
    • 77954368724 scopus 로고    scopus 로고
    • Roles of fragile X mental retardation protein in dopaminergic stimulation-induced synapse-associated protein synthesis and subsequent alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) receptor internalization
    • Wang, H., Kim, S. S., and Zhuo, M. (2010a). Roles of fragile X mental retardation protein in dopaminergic stimulation-induced synapse-associated protein synthesis and subsequent alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) receptor internalization. J. Biol. Chem. 285, 21888-21901. doi: 10.1074/jbc.M110.116293.
    • (2010) J. Biol. Chem. , vol.285 , pp. 21888-21901
    • Wang, H.1    Kim, S.S.2    Zhuo, M.3
  • 286
    • 0346656871 scopus 로고    scopus 로고
    • Developmentally-programmed FMRP expression in oligodendrocytes: A potential role of FMRP in regulating translation in oligodendroglia progenitors
    • Wang, H., Ku, L., Osterhout, D. J., Li, W., Ahmadian, A., Liang, Z., et al. (2004). Developmentally-programmed FMRP expression in oligodendrocytes: a potential role of FMRP in regulating translation in oligodendroglia progenitors. Hum. Mol. Genet. 13, 79-89. doi: 10.1093/hmg/ddh009.
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 79-89
    • Wang, H.1    Ku, L.2    Osterhout, D.J.3    Li, W.4    Ahmadian, A.5    Liang, Z.6
  • 287
    • 84926325289 scopus 로고    scopus 로고
    • Fmr1 KO and fenobam treatment differentially impact distinct synapse populations of mouse neocortex
    • Wang, G. X., Smith, S. J., and Mourrain, P. (2014). Fmr1 KO and fenobam treatment differentially impact distinct synapse populations of mouse neocortex. Neuron 84, 1273-1286. doi: 10.1016/j.neuron.2014.11.016.
    • (2014) Neuron , vol.84 , pp. 1273-1286
    • Wang, G.X.1    Smith, S.J.2    Mourrain, P.3
  • 288
    • 84859780333 scopus 로고    scopus 로고
    • Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome
    • Wang, X., Snape, M., Klann, E., Stone, J. G., Singh, A., Petersen, R. B., et al. (2012b). Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome. J. Neurochem. 121, 672-679. doi: 10.1111/j.1471-4159.2012.07722.x.
    • (2012) J. Neurochem. , vol.121 , pp. 672-679
    • Wang, X.1    Snape, M.2    Klann, E.3    Stone, J.G.4    Singh, A.5    Petersen, R.B.6
  • 289
    • 49849098290 scopus 로고    scopus 로고
    • FMRP acts as a key messenger for dopamine modulation in the forebrain
    • Wang, H., Wu, L. J., Kim, S. S., Lee, F. J., Gong, B., Toyoda, H., et al. (2008b). FMRP acts as a key messenger for dopamine modulation in the forebrain. Neuron 59, 634-647. doi: 10.1016/j.neuron.2008.06.027.
    • (2008) Neuron , vol.59 , pp. 634-647
    • Wang, H.1    Wu, L.J.2    Kim, S.S.3    Lee, F.J.4    Gong, B.5    Toyoda, H.6
  • 290
    • 43749093221 scopus 로고    scopus 로고
    • Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors
    • Wang, H., Wu, L. J., Zhang, F., and Zhuo, M. (2008a). Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors. J. Neurosci.28, 4385-4397. doi: 10.1523/JNEUROSCI.0646-08.2008.
    • (2008) J. Neurosci. , vol.28 , pp. 4385-4397
    • Wang, H.1    Wu, L.J.2    Zhang, F.3    Zhuo, M.4
  • 291
    • 84870727469 scopus 로고    scopus 로고
    • Group I metabotropic glutamate receptor-mediated gene transcription and implications for synaptic plasticity and diseases
    • Wang, H., and Zhuo, M. (2012). Group I metabotropic glutamate receptor-mediated gene transcription and implications for synaptic plasticity and diseases. Front. Pharmacol. 3:189. doi: 10.3389/fphar.2012.00189.
    • (2012) Front. Pharmacol. , vol.3 , pp. 189
    • Wang, H.1    Zhuo, M.2
  • 292
    • 84893842512 scopus 로고    scopus 로고
    • Mitigation of sociocommunicational deficits of autism through oxytocin-induced recovery of medial prefrontal activity: A randomized trial
    • Watanabe, T., Abe, O., Kuwabara, H., Yahata, N., Takano, Y., Iwashiro, N., et al. (2014). Mitigation of sociocommunicational deficits of autism through oxytocin-induced recovery of medial prefrontal activity: a randomized trial. JAMA Psychiatry 71, 166-175. doi: 10.1001/jamapsychiatry.2013.3181.
    • (2014) JAMA Psychiatry , vol.71 , pp. 166-175
    • Watanabe, T.1    Abe, O.2    Kuwabara, H.3    Yahata, N.4    Takano, Y.5    Iwashiro, N.6
  • 293
    • 84872031387 scopus 로고    scopus 로고
    • The therapeutic effect of memantine through the stimulation of synapse formation and dendritic spine maturation in autism and fragile X syndrome
    • Wei, H., Dobkin, C., Sheikh, A. M., Malik, M., Brown, W. T., and Li, X. (2012). The therapeutic effect of memantine through the stimulation of synapse formation and dendritic spine maturation in autism and fragile X syndrome.PLoS One 7:e36981. doi: 10.1371/journal.pone.0036981.
    • (2012) PLoS One , vol.7
    • Wei, H.1    Dobkin, C.2    Sheikh, A.M.3    Malik, M.4    Brown, W.T.5    Li, X.6
  • 294
    • 0027208589 scopus 로고
    • Metabotropic glutamate receptors trigger postsynaptic protein synthesis
    • Weiler, I. J., and Greenough, W. T. (1993). Metabotropic glutamate receptors trigger postsynaptic protein synthesis. Proc. Natl. Acad. Sci. U S A 90, 7168-7171. doi: 10.1073/pnas.90.15.7168.
    • (1993) Proc. Natl. Acad. Sci. U S A , vol.90 , pp. 7168-7171
    • Weiler, I.J.1    Greenough, W.T.2
  • 295
    • 53349143074 scopus 로고    scopus 로고
    • Neuroscience: Fragile dopamine
    • Weinshenker, D., and Warren, S. T. (2008). Neuroscience: fragile dopamine. Nature 455, 607-608. doi: 10.1038/455607a.
    • (2008) Nature , vol.455 , pp. 607-608
    • Weinshenker, D.1    Warren, S.T.2
  • 297
    • 4544236400 scopus 로고    scopus 로고
    • Safety and side effect profile of fluoxetine
    • Wernicke, J. F. (2004). Safety and side effect profile of fluoxetine. Expert Opin. Drug Saf. 3, 495-504. doi: 10.1517/14740338.3.5.495.
    • (2004) Expert Opin. Drug Saf. , vol.3 , pp. 495-504
    • Wernicke, J.F.1
  • 298
    • 84884211307 scopus 로고    scopus 로고
    • What’s hAPPening at synapses? The role of amyloid beta-protein precursor and β-amyloid in neurological disorders
    • Westmark, C. J. (2013). What’s hAPPening at synapses? The role of amyloid beta-protein precursor and β-amyloid in neurological disorders. Mol. Psychiatry 18, 425-434. doi: 10.1038/mp.2012.122.
    • (2013) Mol. Psychiatry , vol.18 , pp. 425-434
    • Westmark, C.J.1
  • 300
    • 33947195786 scopus 로고    scopus 로고
    • FMRP mediates mGluR5-dependent translation of amyloid precursor protein
    • Westmark, C. J., and Malter, J. S. (2007). FMRP mediates mGluR5-dependent translation of amyloid precursor protein. PLoS Biol. 5:e52. doi: 10.1371/journal.pbio.0050052.
    • (2007) PLoS Biol. , vol.5
    • Westmark, C.J.1    Malter, J.S.2
  • 301
    • 77449134798 scopus 로고    scopus 로고
    • MPEP reduces seizure severity in Fmr-1 KO mice over expressing human Abeta
    • Westmark, C. J., Westmark, P. R., and Malter, J. S. (2010). MPEP reduces seizure severity in Fmr-1 KO mice over expressing human Abeta. Int. J. Clin. Exp. Pathol. 3, 56-68..
    • (2010) Int. J. Clin. Exp. Pathol. , vol.3 , pp. 56-68
    • Westmark, C.J.1    Westmark, P.R.2    Malter, J.S.3
  • 302
    • 80055044964 scopus 로고    scopus 로고
    • Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice
    • Westmark, C. J., Westmark, P. R., O’Riordan, K. J., Ray, B. C., Hervey, C. M., Salamat, M. S., et al. (2011). Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice. PLoS One 6:e26549. doi: 10.1371/journal.pone.0026549.
    • (2011) PLoS One , vol.6
    • Westmark, C.J.1    Westmark, P.R.2    O’Riordan, K.J.3    Ray, B.C.4    Hervey, C.M.5    Salamat, M.S.6
  • 303
    • 79958190232 scopus 로고    scopus 로고
    • Activity-dependent calcium signaling and ERK-MAP kinases in neurons: A link to structural plasticity of the nucleus and gene transcription regulation
    • Wiegert, J. S., and Bading, H. (2011). Activity-dependent calcium signaling and ERK-MAP kinases in neurons: a link to structural plasticity of the nucleus and gene transcription regulation. Cell Calcium 49, 296-305. doi: 10.1016/j.ceca.2010.11.009.
    • (2011) Cell Calcium , vol.49 , pp. 296-305
    • Wiegert, J.S.1    Bading, H.2
  • 304
    • 84875223146 scopus 로고    scopus 로고
    • Fragile X syndrome: From targets to treatments
    • Wijetunge, L. S., Chattarji, S., Wyllie, D. J., and Kind, P. C. (2013). Fragile X syndrome: from targets to treatments.Neuropharmacology 68, 83-96. doi: 10.1016/j.neuropharm.2012.11.028.
    • (2013) Neuropharmacology , vol.68 , pp. 83-96
    • Wijetunge, L.S.1    Chattarji, S.2    Wyllie, D.J.3    Kind, P.C.4
  • 305
    • 26044482076 scopus 로고    scopus 로고
    • Case history: The discovery of fluoxetine hydrochloride (Prozac)
    • Wong, D. T., Perry, K. W., and Bymaster, F. P. (2005). Case history: the discovery of fluoxetine hydrochloride (Prozac). Nat. Rev. Drug Discov. 4, 764-774. doi: 10.1038/nrd1821.
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 764-774
    • Wong, D.T.1    Perry, K.W.2    Bymaster, F.P.3
  • 306
    • 77951642306 scopus 로고    scopus 로고
    • Contributions of matrix metalloproteinases to neural plasticity, habituation, associative learning and drug addiction
    • Wright, J. W., and Harding, J. W. (2009). Contributions of matrix metalloproteinases to neural plasticity, habituation, associative learning and drug addiction. Neural Plast. 2009:579382. doi: 10.1155/2009/579382.
    • (2009) Neural Plast. , vol.2009
    • Wright, J.W.1    Harding, J.W.2
  • 307
    • 24344457816 scopus 로고    scopus 로고
    • Suppression of two major fragile X syndrome mouse model phenotypes by the mGluR5 antagonist MPEP
    • Yan, Q. J., Rammal, M., Tranfaglia, M., and Bauchwitz, R. P. (2005). Suppression of two major fragile X syndrome mouse model phenotypes by the mGluR5 antagonist MPEP. Neuropharmacology 49, 1053-1066. doi: 10.1016/j.neuropharm.2005.06.004.
    • (2005) Neuropharmacology , vol.49 , pp. 1053-1066
    • Yan, Q.J.1    Rammal, M.2    Tranfaglia, M.3    Bauchwitz, R.P.4
  • 308
    • 78650215787 scopus 로고    scopus 로고
    • Fragile X mice: Reduced long-term potentiation and N-Methyl-D-Aspartate receptor-mediated neurotransmission in dentate gyrus
    • Yun, S. H., and Trommer, B. L. (2011). Fragile X mice: reduced long-term potentiation and N-Methyl-D-Aspartate receptor-mediated neurotransmission in dentate gyrus. J. Neurosci. Res. 89, 176-182. doi: 10.1002/jnr.22546.
    • (2011) J. Neurosci. Res. , vol.89 , pp. 176-182
    • Yun, S.H.1    Trommer, B.L.2
  • 309
    • 71549145629 scopus 로고    scopus 로고
    • Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome
    • Yuskaitis, C. J., Mines, M. A., King, M. K., Sweatt, J. D., Miller, C. A., and Jope, R. S. (2010). Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome. Biochem. Pharmacol. 79, 632-646. doi: 10.1016/j.bcp.2009.09.023.
    • (2010) Biochem. Pharmacol. , vol.79 , pp. 632-646
    • Yuskaitis, C.J.1    Mines, M.A.2    King, M.K.3    Sweatt, J.D.4    Miller, C.A.5    Jope, R.S.6
  • 310
    • 36849075300 scopus 로고    scopus 로고
    • Oral treatment with desipramine improves breathing and life span in Rett syndrome mouse model
    • Zanella, S., Mebarek, S., Lajard, A. M., Picard, N., Dutschmann, M., and Hilaire, G. (2008). Oral treatment with desipramine improves breathing and life span in Rett syndrome mouse model. Respir. Physiol. Neurobiol. 160, 116-121. doi: 10.1016/j.resp.2007.08.009.
    • (2008) Respir. Physiol. Neurobiol. , vol.160 , pp. 116-121
    • Zanella, S.1    Mebarek, S.2    Lajard, A.M.3    Picard, N.4    Dutschmann, M.5    Hilaire, G.6
  • 311
    • 77951528668 scopus 로고    scopus 로고
    • Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome
    • Zhang, L., and Alger, B. E. (2010). Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome. J. Neurosci. 30, 5724-5729. doi: 10.1523/JNEUROSCI.0795-10.2010.
    • (2010) J. Neurosci. , vol.30 , pp. 5724-5729
    • Zhang, L.1    Alger, B.E.2
  • 312
    • 84925225933 scopus 로고    scopus 로고
    • Dendritic channelopathies contribute to neocortical and sensory hyperexcitability in Fmr1(-/y) mice
    • Zhang, Y., Bonnan, A., Bony, G., Ferezou, I., Pietropaolo, S., Ginger, M., et al. (2014b). Dendritic channelopathies contribute to neocortical and sensory hyperexcitability in Fmr1(-/y) mice. Nat. Neurosci. 17, 1701-1709. doi: 10.1038/nn.3864.
    • (2014) Nat. Neurosci. , vol.17 , pp. 1701-1709
    • Zhang, Y.1    Bonnan, A.2    Bony, G.3    Ferezou, I.4    Pietropaolo, S.5    Ginger, M.6
  • 313
    • 84866172141 scopus 로고    scopus 로고
    • Regulation of neuronal excitability by interaction of fragile X mental retardation protein with slack potassium channels
    • Zhang, Y., Brown, M. R., Hyland, C., Chen, Y., Kronengold, J., Fleming, M. R., et al. (2012). Regulation of neuronal excitability by interaction of fragile X mental retardation protein with slack potassium channels. J. Neurosci. 32, 15318-15327. doi: 10.1523/JNEUROSCI.2162-12.2012.
    • (2012) J. Neurosci. , vol.32 , pp. 15318-15327
    • Zhang, Y.1    Brown, M.R.2    Hyland, C.3    Chen, Y.4    Kronengold, J.5    Fleming, M.R.6
  • 314
    • 84893709462 scopus 로고    scopus 로고
    • Loss of MeCP2 from forebrain excitatory neurons leads to cortical hyperexcitation and seizures
    • Zhang, W., Peterson, M., Beyer, B., Frankel, W. N., and Zhang, Z. W. (2014a). Loss of MeCP2 from forebrain excitatory neurons leads to cortical hyperexcitation and seizures. J. Neurosci. 34, 2754-2763. doi: 10.1523/JNEUROSCI.4900-12.2014.
    • (2014) J. Neurosci. , vol.34 , pp. 2754-2763
    • Zhang, W.1    Peterson, M.2    Beyer, B.3    Frankel, W.N.4    Zhang, Z.W.5
  • 315
    • 54849419578 scopus 로고    scopus 로고
    • The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation
    • Zhang, Y., Venkitaramani, D. V., Gladding, C. M., Kurup, P., Molnar, E., Collingridge, G. L., et al. (2008). The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation. J. Neurosci. 28, 10561-10566. doi: 10.1523/JNEUROSCI.2666-08.2008.
    • (2008) J. Neurosci. , vol.28 , pp. 10561-10566
    • Zhang, Y.1    Venkitaramani, D.V.2    Gladding, C.M.3    Kurup, P.4    Molnar, E.5    Collingridge, G.L.6
  • 316
    • 16344390935 scopus 로고    scopus 로고
    • A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC
    • Zhang, H., Webb, D. J., Asmussen, H., Niu, S., and Horwitz, A. F. (2005). A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC. J. Neurosci. 25, 3379-3388. doi: 10.1523/jneurosci.3553-04.2005.
    • (2005) J. Neurosci. , vol.25 , pp. 3379-3388
    • Zhang, H.1    Webb, D.J.2    Asmussen, H.3    Niu, S.4    Horwitz, A.F.5
  • 317
    • 77952973905 scopus 로고    scopus 로고
    • MeCP2 is required for normal development of GABAergic circuits in the thalamus
    • Zhang, Z. W., Zak, J. D., and Liu, H. (2010). MeCP2 is required for normal development of GABAergic circuits in the thalamus. J. Neurophysiol. 103, 2470-2481. doi: 10.1152/jn.00601.2009.
    • (2010) J. Neurophysiol. , vol.103 , pp. 2470-2481
    • Zhang, Z.W.1    Zak, J.D.2    Liu, H.3
  • 318
    • 2542473205 scopus 로고    scopus 로고
    • Comparative signaling pathways of insulin-like growth factor-1 and brain-derived neurotrophic factor in hippocampal neurons and the role of the PI3 kinase pathway in cell survival
    • Zheng, W. H., and Quirion, R. (2004). Comparative signaling pathways of insulin-like growth factor-1 and brain-derived neurotrophic factor in hippocampal neurons and the role of the PI3 kinase pathway in cell survival. J. Neurochem. 89, 844-852. doi: 10.1111/j.1471-4159.2004.02350.x.
    • (2004) J. Neurochem. , vol.89 , pp. 844-852
    • Zheng, W.H.1    Quirion, R.2
  • 319
    • 0036845819 scopus 로고    scopus 로고
    • Glatiramer acetate-specific T-helper 1- and 2-type cell lines produce BDNF: Implications for multiple sclerosis therapy. Brain-derived neurotrophic factor
    • Ziemssen, T., Kümpfel, T., Klinkert, W. E., Neuhaus, O., and Hohlfeld, R. (2002). Glatiramer acetate-specific T-helper 1- and 2-type cell lines produce BDNF: implications for multiple sclerosis therapy. Brain-derived neurotrophic factor. Brain 125, 2381-2391. doi: 10.1093/brain/awf252.
    • (2002) Brain , vol.125 , pp. 2381-2391
    • Ziemssen, T.1    Kümpfel, T.2    Klinkert, W.E.3    Neuhaus, O.4    Hohlfeld, R.5
  • 320
    • 33845996905 scopus 로고    scopus 로고
    • Aminoglycoside-induced translational read-through in disease: Overcoming nonsense mutations by pharmacogenetic therapy
    • Zingman, L. V., Park, S., Olson, T. M., Alekseev, A. E., and Terzic, A. (2007). Aminoglycoside-induced translational read-through in disease: overcoming nonsense mutations by pharmacogenetic therapy. Clin. Pharmacol. Ther. 81, 99-103. doi: 10.1038/sj.clpt.6100012.
    • (2007) Clin. Pharmacol. Ther. , vol.81 , pp. 99-103
    • Zingman, L.V.1    Park, S.2    Olson, T.M.3    Alekseev, A.E.4    Terzic, A.5
  • 321
    • 84862659562 scopus 로고    scopus 로고
    • Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities
    • pii:a009886
    • Zoghbi, H. Y., and Bear, M. F. (2012). Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. Cold Spring Harb. Perspect. Biol. 4, pii:a009886. doi: 10.1101/cshperspect.a009886.
    • (2012) Cold Spring Harb. Perspect. Biol. , vol.4
    • Zoghbi, H.Y.1    Bear, M.F.2
  • 322
    • 57349114703 scopus 로고    scopus 로고
    • Inactivation of the maternal fragile X gene results in sensitization of GABAB receptor function in the offspring
    • Zupan, B., and Toth, M. (2008). Inactivation of the maternal fragile X gene results in sensitization of GABAB receptor function in the offspring. J. Pharmacol. Exp. Ther. 327, 820-826. doi: 10.1124/jpet.108.143990.
    • (2008) J. Pharmacol. Exp. Ther. , vol.327 , pp. 820-826
    • Zupan, B.1    Toth, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.