-
1
-
-
27744583133
-
Impaired metabotropic glutamate receptor/phospholipase C signaling pathway in the cerebral cortex in Alzheimer's disease and dementia with Lewy bodies correlates with stage of Alzheimer's-disease-related changes
-
Albasanz J. L., Dalfo E., Ferrer I., and, Martin M., (2005) Impaired metabotropic glutamate receptor/phospholipase C signaling pathway in the cerebral cortex in Alzheimer's disease and dementia with Lewy bodies correlates with stage of Alzheimer's-disease-related changes. Neurobiol. Dis. 20, 685-693.
-
(2005)
Neurobiol. Dis.
, vol.20
, pp. 685-693
-
-
Albasanz, J.L.1
Dalfo, E.2
Ferrer, I.3
Martin, M.4
-
2
-
-
0027377580
-
FMR1 protein: Conserved RNP family domains and selective RNA binding
-
Ashley C. T., Jr, Wilkinson K. D., Reines D., and, Warren S. T., (1993) FMR1 protein: conserved RNP family domains and selective RNA binding. Science 262, 563-566.
-
(1993)
Science
, vol.262
, pp. 563-566
-
-
Ashley, Jr.C.T.1
Wilkinson, K.D.2
Reines, D.3
Warren, S.T.4
-
3
-
-
37249013214
-
-
Auris Medical AG. (-[cited 2013 Sep 11) Efficacy of AM-111 in patients with acute sensorineural hearing loss [Internet], Bethesda, MD: National Library of Medicine (US). Available NLM identifier: NCT00802425
-
Auris Medical AG. (2008 -[cited 2013 Sep 11) Efficacy of AM-111 in patients with acute sensorineural hearing loss. In: ClinicalTrials.gov [Internet], Bethesda, MD: National Library of Medicine (US). Available at: http://clinicaltrials.gov/ct2/show/NCT00802425 NLM identifier: NCT00802425.
-
(2008)
ClinicalTrials.gov
-
-
-
5
-
-
3042647610
-
The mGluR theory of fragile X mental retardation
-
Bear M. F., Huber K. M., and, Warren S. T., (2004) The mGluR theory of fragile X mental retardation. Trends Neurosci. 27, 370-377.
-
(2004)
Trends Neurosci.
, vol.27
, pp. 370-377
-
-
Bear, M.F.1
Huber, K.M.2
Warren, S.T.3
-
6
-
-
78650962524
-
Deconstruction for reconstruction: The role of proteolysis in neural plasticity and disease
-
Bingol B., and, Sheng M., (2011) Deconstruction for reconstruction: the role of proteolysis in neural plasticity and disease. Neuron 69, 22-32.
-
(2011)
Neuron
, vol.69
, pp. 22-32
-
-
Bingol, B.1
Sheng, M.2
-
7
-
-
0035152487
-
Cell-permeable peptide inhibitors of JNK: Novel blockers of beta-cell death
-
Bonny C., Oberson A., Negri S., Sauser C., and, Schorderet D. F., (2001) Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Diabetes 50, 77-82.
-
(2001)
Diabetes
, vol.50
, pp. 77-82
-
-
Bonny, C.1
Oberson, A.2
Negri, S.3
Sauser, C.4
Schorderet, D.F.5
-
8
-
-
0141724805
-
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia
-
Borsello T., Clarke P. G., Hirt L., Vercelli A., Repici M., Schorderet D. F., Bogousslavsky J., and, Bonny C., (2003) A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nat. Med. 9, 1180-1186.
-
(2003)
Nat. Med.
, vol.9
, pp. 1180-1186
-
-
Borsello, T.1
Clarke, P.G.2
Hirt, L.3
Vercelli, A.4
Repici, M.5
Schorderet, D.F.6
Bogousslavsky, J.7
Bonny, C.8
-
9
-
-
0032546976
-
Purified recombinant Fmrp exhibits selective RNA binding as an intrinsic property of the fragile X mental retardation protein
-
Brown V., Small K., Lakkis L., Feng Y., Gunter C., Wilkinson K. D., and, Warren S. T., (1998) Purified recombinant Fmrp exhibits selective RNA binding as an intrinsic property of the fragile X mental retardation protein. J. Biol. Chem. 273, 15521-15527.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 15521-15527
-
-
Brown, V.1
Small, K.2
Lakkis, L.3
Feng, Y.4
Gunter, C.5
Wilkinson, K.D.6
Warren, S.T.7
-
10
-
-
84861760725
-
-
(-[cited 2013 Sep 11) A study to characterize the safety, PK and biological activity of CC-930 in idiopathic pulmonary fibrosis (IPF). ClinicalTrials.gov [Internet], Bethesda, MD: National Library of Medicine (US). Available from NLM identifier: NCT01203943
-
Celgene Corporation. (2010 -[cited 2013 Sep 11) A study to characterize the safety, PK and biological activity of CC-930 in idiopathic pulmonary fibrosis (IPF). In: ClinicalTrials.gov [Internet], Bethesda, MD: National Library of Medicine (US). Available from: http://clinicaltrials.gov/ct2/show/ NCT01203943 NLM identifier: NCT01203943.
-
(2010)
Celgene Corporation
-
-
-
12
-
-
79952315521
-
Pharmacological reversal of synaptic plasticity deficits in the mouse model of fragile X syndrome by group II mGluR antagonist or lithium treatment
-
Choi C. H., Schoenfeld B. P., Bell A. J., et al,. (2011) Pharmacological reversal of synaptic plasticity deficits in the mouse model of fragile X syndrome by group II mGluR antagonist or lithium treatment. Brain Res. 1380, 106-119.
-
(2011)
Brain Res.
, vol.1380
, pp. 106-119
-
-
Choi, C.H.1
Schoenfeld, B.P.2
Bell, A.J.3
-
13
-
-
84886953546
-
The translation of translational control by FMRP: Therapeutic targets for FXS
-
Darnell J. C., and, Klann E,. (2013) The translation of translational control by FMRP: therapeutic targets for FXS. Nat. Neurosci. 16, 1-7.
-
(2013)
Nat. Neurosci.
, vol.16
, pp. 1-7
-
-
Darnell, J.C.1
Klann, E.2
-
14
-
-
79960779323
-
FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism
-
Darnell J. C., Van-Driesche S. J., Zhang C., et al,. (2011) FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism. Cell 146, 247-261.
-
(2011)
Cell
, vol.146
, pp. 247-261
-
-
Darnell, J.C.1
Van-Driesche, S.J.2
Zhang, C.3
-
15
-
-
0026345716
-
Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox
-
Fu Y. H., Kuhl D. P., Pizzuti A., et al,. (1991) Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox. Cell 67, 1047-1058.
-
(1991)
Cell
, vol.67
, pp. 1047-1058
-
-
Fu, Y.H.1
Kuhl, D.P.2
Pizzuti, A.3
-
16
-
-
2442637740
-
Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1
-
Gallagher S. M., Daly C. A., Bear M. F., and, Huber K. M., (2004) Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1. J. Neurosci. 24, 4859-4864.
-
(2004)
J. Neurosci.
, vol.24
, pp. 4859-4864
-
-
Gallagher, S.M.1
Daly, C.A.2
Bear, M.F.3
Huber, K.M.4
-
17
-
-
84856078399
-
Therapeutic strategies in fragile X syndrome: Dysregulated mGluR signaling and beyond
-
Gross C., Berry-Kravis E. M., and, Bassell G. J., (2012) Therapeutic strategies in fragile X syndrome: dysregulated mGluR signaling and beyond. Neuropsychopharmacology 37, 178-195.
-
(2012)
Neuropsychopharmacology
, vol.37
, pp. 178-195
-
-
Gross, C.1
Berry-Kravis, E.M.2
Bassell, G.J.3
-
18
-
-
35248880092
-
TAT transduction: The molecular mechanism and therapeutic prospects
-
Gump J. M., and, Dowdy S. F., (2007) TAT transduction: the molecular mechanism and therapeutic prospects. Trends Mol. Med. 13, 443-448.
-
(2007)
Trends Mol. Med.
, vol.13
, pp. 443-448
-
-
Gump, J.M.1
Dowdy, S.F.2
-
19
-
-
50049086691
-
The fragile X prevalence paradox
-
Hagerman P. J., (2008) The fragile X prevalence paradox. J. Med. Genet. 45, 498-499.
-
(2008)
J. Med. Genet.
, vol.45
, pp. 498-499
-
-
Hagerman, P.J.1
-
20
-
-
0034685813
-
Role for Rapid dendritic protein synthesis in hippocampal mglur-dependent long-term depression
-
Huber K. M., Kayser M. S., and, Bear M. F., (2000) Role for Rapid dendritic protein synthesis in hippocampal mglur-dependent long-term depression. Science 288, 1254-1256.
-
(2000)
Science
, vol.288
, pp. 1254-1256
-
-
Huber, K.M.1
Kayser, M.S.2
Bear, M.F.3
-
21
-
-
0037188502
-
Altered synaptic plasticity in a mouse model of fragile X mental retardation
-
Huber K. M., Gallagher S. M., Warren S. T., and, Bear M. F., (2002) Altered synaptic plasticity in a mouse model of fragile X mental retardation. Proc. Natl Acad. Sci. USA 99, 7746-7750.
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 7746-7750
-
-
Huber, K.M.1
Gallagher, S.M.2
Warren, S.T.3
Bear, M.F.4
-
22
-
-
0034639857
-
Understanding the molecular basis of fragile X syndrome
-
Jin P., and, Warren S. T., (2000) Understanding the molecular basis of fragile X syndrome. Hum. Mol. Genet. 9, 901-908.
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 901-908
-
-
Jin, P.1
Warren, S.T.2
-
23
-
-
0025800165
-
Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG)n
-
Kremer E. J., Pritchard M., Lynch M., et al,. (1991) Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG)n. Science 252, 1711-1714.
-
(1991)
Science
, vol.252
, pp. 1711-1714
-
-
Kremer, E.J.1
Pritchard, M.2
Lynch, M.3
-
24
-
-
79551594543
-
Toward fulfilling the promise of molecular medicine in fragile X syndrome
-
Krueger D. D., and, Bear M. F., (2011) Toward fulfilling the promise of molecular medicine in fragile X syndrome. Annu. Rev. Med. 62, 411-429.
-
(2011)
Annu. Rev. Med.
, vol.62
, pp. 411-429
-
-
Krueger, D.D.1
Bear, M.F.2
-
25
-
-
35148838569
-
Brain-derived neurotrophic factor rescues synaptic plasticity in a mouse model of fragile X syndrome
-
Lauterborn J. C., Rex C. S., Kramar E., Chen L. Y., Pandyarajan V., Lynch G., and, Gall C. M., (2007) Brain-derived neurotrophic factor rescues synaptic plasticity in a mouse model of fragile X syndrome. J. Neurosci. 27, 10685-10694.
-
(2007)
J. Neurosci.
, vol.27
, pp. 10685-10694
-
-
Lauterborn, J.C.1
Rex, C.S.2
Kramar, E.3
Chen, L.Y.4
Pandyarajan, V.5
Lynch, G.6
Gall, C.M.7
-
26
-
-
77952474914
-
Fragile X syndrome and Alzheimer's disease: Another story about APP and beta-amyloid
-
Malter J. S., Ray B. C., Westmark P. R., and, Westmark C. J., (2010) Fragile X syndrome and Alzheimer's disease: another story about APP and beta-amyloid. Curr. Alzheimer Res. 7, 200-206.
-
(2010)
Curr. Alzheimer Res.
, vol.7
, pp. 200-206
-
-
Malter, J.S.1
Ray, B.C.2
Westmark, P.R.3
Westmark, C.J.4
-
27
-
-
0035478618
-
Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand
-
Morishima Y., Gotoh Y., Zieg J., Barrett T., Takano H., Flavell R., Davis R. J., Shirasaki Y., and, Greenberg M. E., (2001) Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand. J. Neurosci. 21, 7551-7560.
-
(2001)
J. Neurosci.
, vol.21
, pp. 7551-7560
-
-
Morishima, Y.1
Gotoh, Y.2
Zieg, J.3
Barrett, T.4
Takano, H.5
Flavell, R.6
Davis, R.J.7
Shirasaki, Y.8
Greenberg, M.E.9
-
28
-
-
34249064936
-
Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome
-
Muddashetty R. S., Kelic S., Gross C., Xu M., and, Bassell G. J., (2007) Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome. J. Neurosci. 27, 5338-5348.
-
(2007)
J. Neurosci.
, vol.27
, pp. 5338-5348
-
-
Muddashetty, R.S.1
Kelic, S.2
Gross, C.3
Xu, M.4
Bassell, G.J.5
-
29
-
-
79958045841
-
Reversible Inhibition of PSD-95 mRNA Translation by miR-125a, FMRP Phosphorylation, and mGluR Signaling
-
Muddashetty R. S., Nalavadi V. C., Gross C., Yao X., Xing L., Laur O., Warren S. T., and, Bassell G. J., (2011) Reversible Inhibition of PSD-95 mRNA Translation by miR-125a, FMRP Phosphorylation, and mGluR Signaling. Mol. Cell 42, 673-688.
-
(2011)
Mol. Cell
, vol.42
, pp. 673-688
-
-
Muddashetty, R.S.1
Nalavadi, V.C.2
Gross, C.3
Yao, X.4
Xing, L.5
Laur, O.6
Warren, S.T.7
Bassell, G.J.8
-
30
-
-
37549044298
-
FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group i mGluR and mediated by PP2A
-
Narayanan U., Nalavadi V., Nakamoto M., Pallas D. C., Ceman S., Bassell G. J., and, Warren S. T., (2007) FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A. J. Neurosci. 27, 14349-14357.
-
(2007)
J. Neurosci.
, vol.27
, pp. 14349-14357
-
-
Narayanan, U.1
Nalavadi, V.2
Nakamoto, M.3
Pallas, D.C.4
Ceman, S.5
Bassell, G.J.6
Warren, S.T.7
-
31
-
-
49649106751
-
S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade
-
Narayanan U., Nalavadi V., Nakamoto M., Thomas G., Ceman S., Bassell G. J., and, Warren S. T., (2008) S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade. J. Biol. Chem. 283, 18478-18482.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 18478-18482
-
-
Narayanan, U.1
Nalavadi, V.2
Nakamoto, M.3
Thomas, G.4
Ceman, S.5
Bassell, G.J.6
Warren, S.T.7
-
32
-
-
0033019102
-
The up-regulation of metabotropic glutamate receptor 5 (mGluR5) in Down's syndrome brains
-
Oka A., and, Takashima S., (1999) The up-regulation of metabotropic glutamate receptor 5 (mGluR5) in Down's syndrome brains. Acta Neuropathol. 97, 275-278.
-
(1999)
Acta Neuropathol.
, vol.97
, pp. 275-278
-
-
Oka, A.1
Takashima, S.2
-
33
-
-
78449259794
-
Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome
-
Osterweil E. K., Krueger D. D., Reinhold K., and, Bear M. F., (2010) Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome. J. Neurosci. 30, 15616-15627.
-
(2010)
J. Neurosci.
, vol.30
, pp. 15616-15627
-
-
Osterweil, E.K.1
Krueger, D.D.2
Reinhold, K.3
Bear, M.F.4
-
34
-
-
46149087988
-
Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD
-
Park S., Park J. M., Kim S., et al,. (2008) Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. Neuron 59, 70-83.
-
(2008)
Neuron
, vol.59
, pp. 70-83
-
-
Park, S.1
Park, J.M.2
Kim, S.3
-
35
-
-
84855649801
-
Novel role of c-jun N-terminal kinase in regulating the initiation of cap-dependent translation
-
Patel M. R., Sadiq A. A., Jay-Dixon J., Jirakulaporn T., Jacobson B. A., Farassati F., Bitterman P. B., and, Kratzke R. A., (2012) Novel role of c-jun N-terminal kinase in regulating the initiation of cap-dependent translation. Int. J. Oncol. 40, 577-582.
-
(2012)
Int. J. Oncol.
, vol.40
, pp. 577-582
-
-
Patel, M.R.1
Sadiq, A.A.2
Jay-Dixon, J.3
Jirakulaporn, T.4
Jacobson, B.A.5
Farassati, F.6
Bitterman, P.B.7
Kratzke, R.A.8
-
36
-
-
80052811773
-
JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models
-
Ploia C., Antoniou X., Sclip A., et al,. (2011) JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models. J. Alzheimer's Dis. 26, 315-329.
-
(2011)
J. Alzheimer's Dis.
, vol.26
, pp. 315-329
-
-
Ploia, C.1
Antoniou, X.2
Sclip, A.3
-
37
-
-
38349029199
-
Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation
-
Ronesi J. A., and, Huber K. M., (2008a) Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation. J. Neurosci. 28, 543-547.
-
(2008)
J. Neurosci.
, vol.28
, pp. 543-547
-
-
Ronesi, J.A.1
Huber, K.M.2
-
38
-
-
45149122378
-
Metabotropic glutamate receptors and fragile x mental retardation protein: Partners in translational regulation at the synapse
-
Ronesi J. A., and, Huber K. M,. (2008b) Metabotropic glutamate receptors and fragile x mental retardation protein: partners in translational regulation at the synapse. Sci. Signal. 1, pe6.
-
(2008)
Sci. Signal.
, vol.1
-
-
Ronesi, J.A.1
Huber, K.M.2
-
39
-
-
84862777306
-
Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome
-
Ronesi J. A., Collins K. A., Hays S. A., et al,. (2012) Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome. Nat. Neurosci. 15, 431-440.
-
(2012)
Nat. Neurosci.
, vol.15
, pp. 431-440
-
-
Ronesi, J.A.1
Collins, K.A.2
Hays, S.A.3
-
40
-
-
84857216258
-
Role of the JNK pathway in human diseases
-
Sabapathy K., (2012) Role of the JNK pathway in human diseases. Prog. Mol. Biol. Transl. Sci. 106, 145-169.
-
(2012)
Prog. Mol. Biol. Transl. Sci.
, vol.106
, pp. 145-169
-
-
Sabapathy, K.1
-
41
-
-
83755171439
-
C-Jun N-terminal kinase regulates soluble Abeta oligomers and cognitive impairment in AD mouse model
-
Sclip A., Antoniou X., Colombo A., et al,. (2011) c-Jun N-terminal kinase regulates soluble Abeta oligomers and cognitive impairment in AD mouse model. J. Biol. Chem. 286, 43871-43880.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 43871-43880
-
-
Sclip, A.1
Antoniou, X.2
Colombo, A.3
-
42
-
-
70349909566
-
Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice
-
Shang Y., Wang H., Mercaldo V., Li X., Chen T., and, Zhuo M., (2009) Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice. J. Neurochem. 111, 635-646.
-
(2009)
J. Neurochem.
, vol.111
, pp. 635-646
-
-
Shang, Y.1
Wang, H.2
Mercaldo, V.3
Li, X.4
Chen, T.5
Zhuo, M.6
-
43
-
-
74949102875
-
Dysregulation of mTOR signaling in fragile X syndrome
-
Sharma A., Hoeffer C. A., Takayasu Y., Miyawaki T., McBride S. M., Klann E., and, Zukin R. S., (2010) Dysregulation of mTOR signaling in fragile X syndrome. J. Neurosci. 30, 694-702.
-
(2010)
J. Neurosci.
, vol.30
, pp. 694-702
-
-
Sharma, A.1
Hoeffer, C.A.2
Takayasu, Y.3
Miyawaki, T.4
McBride, S.M.5
Klann, E.6
Zukin, R.S.7
-
44
-
-
79955625469
-
Early continuous inhibition of group 1 mGlu signaling partially rescues dendritic spine abnormalities in the Fmr1 knockout mouse model for fragile X syndrome
-
Su T., Fan H. X., Jiang T., Sun W. W., Den W. Y., Gao M. M., Chen S. Q., Zhao Q. H., and, Yi Y. H., (2011) Early continuous inhibition of group 1 mGlu signaling partially rescues dendritic spine abnormalities in the Fmr1 knockout mouse model for fragile X syndrome. Psychopharmacology 215, 291-300.
-
(2011)
Psychopharmacology
, vol.215
, pp. 291-300
-
-
Su, T.1
Fan, H.X.2
Jiang, T.3
Sun, W.W.4
Den, W.Y.5
Gao, M.M.6
Chen, S.Q.7
Zhao, Q.H.8
Yi, Y.H.9
-
45
-
-
34249776342
-
C-Jun phosphorylation in Alzheimer disease
-
Thakur A., Wang X., Siedlak S. L., Perry G., Smith M. A., and, Zhu X., (2007) c-Jun phosphorylation in Alzheimer disease. J. Neurosci. Res. 85, 1668-1673.
-
(2007)
J. Neurosci. Res.
, vol.85
, pp. 1668-1673
-
-
Thakur, A.1
Wang, X.2
Siedlak, S.L.3
Perry, G.4
Smith, M.A.5
Zhu, X.6
-
46
-
-
0030786344
-
Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase
-
Tournier C., Whitmarsh A. J., Cavanagh J., Barrett T., and, Davis R. J., (1997) Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proc. Natl Acad. Sci. USA 94, 7337-7342.
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 7337-7342
-
-
Tournier, C.1
Whitmarsh, A.J.2
Cavanagh, J.3
Barrett, T.4
Davis, R.J.5
-
47
-
-
68649093278
-
Protein translation in synaptic plasticity: MGluR-LTD, Fragile X
-
Waung M. W., and, Huber K. M., (2009) Protein translation in synaptic plasticity: mGluR-LTD, Fragile X. Curr. Opin. Neurobiol. 19, 319-326.
-
(2009)
Curr. Opin. Neurobiol.
, vol.19
, pp. 319-326
-
-
Waung, M.W.1
Huber, K.M.2
-
48
-
-
33947195786
-
FMRP mediates mGluR5-dependent translation of amyloid precursor protein
-
Westmark C. J., and, Malter J. S., (2007) FMRP mediates mGluR5-dependent translation of amyloid precursor protein. PLoS Biol. 5, e52.
-
(2007)
PLoS Biol.
, vol.5
-
-
Westmark, C.J.1
Malter, J.S.2
-
49
-
-
77449134798
-
MPEP reduces seizure severity in Fmr-1 KO mice over expressing human Abeta
-
Westmark C. J., Westmark P. R., and, Malter J. S., (2009) MPEP reduces seizure severity in Fmr-1 KO mice over expressing human Abeta. Int. J. Clin. Exp. Pathol. 3, 56-68.
-
(2009)
Int. J. Clin. Exp. Pathol.
, vol.3
, pp. 56-68
-
-
Westmark, C.J.1
Westmark, P.R.2
Malter, J.S.3
-
50
-
-
33847765450
-
Proapoptotic Nix Activates the JNK Pathway by Interacting with POSH and Mediates Death in a Parkinson Disease Model
-
Wilhelm M., Xu Z., Kukekov N. V., Gire S., and, Greene L. A., (2007) Proapoptotic Nix Activates the JNK Pathway by Interacting with POSH and Mediates Death in a Parkinson Disease Model. J. Biol. Chem. 282, 1288-1295.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 1288-1295
-
-
Wilhelm, M.1
Xu, Z.2
Kukekov, N.V.3
Gire, S.4
Greene, L.A.5
-
51
-
-
84862923333
-
Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein
-
Wilhelm M., Kukekov N. V., Schmit T. L., Biagas K. V., Sproul A. A., Gire S., Maes M. E., Xu Z., and, Greene L. A., (2012) Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein. J. Biol. Chem. 287, 2247-2256.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 2247-2256
-
-
Wilhelm, M.1
Kukekov, N.V.2
Schmit, T.L.3
Biagas, K.V.4
Sproul, A.A.5
Gire, S.6
Maes, M.E.7
Xu, Z.8
Greene, L.A.9
-
52
-
-
84890122815
-
-
(-[cited 2013 Sep 11) ClinicalTrials.gov [Internet], Bethesda, MD: National Library of Medicine (US). Available NLM identifier: NCT01570205
-
Xigen SA,. (2012 -[cited 2013 Sep 11) Safety, tolerability and PK of a single IV infusion of 10, 40, and 80 μg/kg XG-102 administered to healthy volunteers. In: ClinicalTrials.gov [Internet], Bethesda, MD: National Library of Medicine (US). Available at: http://clinicaltrials.gov/ct2/show/NCT01570205 NLM identifier: NCT01570205.
-
(2012)
Safety, Tolerability and PK of A Single IV Infusion of 10, 40, and 80 μg/kg XG-102 Administered to Healthy Volunteers
-
-
Xigen, S.A.1
-
53
-
-
24344457816
-
Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP
-
Yan Q. J., Rammal M., Tranfaglia M., and, Bauchwitz R. P., (2005) Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP. Neuropharmacology 49, 1053-1066.
-
(2005)
Neuropharmacology
, vol.49
, pp. 1053-1066
-
-
Yan, Q.J.1
Rammal, M.2
Tranfaglia, M.3
Bauchwitz, R.P.4
-
54
-
-
32544448949
-
A signaling mechanism from G{alpha}q-protein-coupled metabotropic glutamate receptors to gene expression: Role of the c-Jun N-terminal kinase pathway
-
Yang L., Mao L., Chen H., Catavsan M., Kozinn J., Arora A., Liu X., and, Wang J. Q., (2006) A signaling mechanism from G{alpha}q-protein-coupled metabotropic glutamate receptors to gene expression: role of the c-Jun N-terminal kinase pathway. J. Neurosci. 26, 971-980.
-
(2006)
J. Neurosci.
, vol.26
, pp. 971-980
-
-
Yang, L.1
Mao, L.2
Chen, H.3
Catavsan, M.4
Kozinn, J.5
Arora, A.6
Liu, X.7
Wang, J.Q.8
-
55
-
-
0026347628
-
Fragile X genotype characterized by an unstable region of DNA
-
Yu S., Pritchard M., Kremer E., et al,. (1991) Fragile X genotype characterized by an unstable region of DNA. Science 252, 1179-1181.
-
(1991)
Science
, vol.252
, pp. 1179-1181
-
-
Yu, S.1
Pritchard, M.2
Kremer, E.3
|