A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome

DMM Disease Models and Mechanisms

Volumn 7, Issue 9, 2014, Pages 1047-1055

  Kron, Miriam ^a   Lang, Min ^a   Adams, Ian T ^a   Sceniak, Michael ^a   Longo, Frank ^b   Katz, David M ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Arousal; Brain derived neurotrophic factor (BDNF); Brainstem; Mecp2; Respiration

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; LM 22A 4; PARTIAL AGONIST; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; CARBAZOLE DERIVATIVE; INDOLE ALKALOID; MECP2 PROTEIN, MOUSE; METHYL CPG BINDING PROTEIN 2; PROTEIN KINASE INHIBITOR; STAUROSPORINE AGLYCONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APNEA; AROUSAL; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DRUG SCREENING; EVOKED BRAIN STEM RESPONSE; FEMALE; IN VIVO STUDY; MALE; MOUSE; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP TECHNIQUE; POSTSYNAPTIC INHIBITION; RESPIRATORY TRACT DISEASE; RETT SYNDROME; SENSORY NERVE; SOLITARY TRACT NUCLEUS; ANIMAL; BREATHING; CHEMISTRY; DISEASE MODEL; GENETICS; HUMAN; KNOCKOUT MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; APNEA; BRAIN-DERIVED NEUROTROPHIC FACTOR; CARBAZOLES; DISEASE MODELS, ANIMAL; HUMANS; INDOLE ALKALOIDS; METHYL-CPG-BINDING PROTEIN 2; MICE; MICE, KNOCKOUT; PROTEIN KINASE INHIBITORS; RESPIRATION; RETT SYNDROME;

EID: 84907192606     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.016030     Document Type: Article

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