메뉴 건너뛰기




Volumn 7, Issue 3, 2010, Pages 200-206

Fragile x Syndrome and Alzheimer's disease: Another story about APP and β-Amyloid

Author keywords

Amyloid precursor protein (APP) and beta amyloid; Fragile x syndrome (FXS); Metabotropic glutamate receptors (mGluR)

Indexed keywords

2 METHYL 6 (2 PHENYLVINYL)PYRIDINE; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; AMYLOID BETA PROTEIN; FRAGILE X MENTAL RETARDATION PROTEIN; MESSENGER RNA; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 5;

EID: 77952474914     PISSN: 15672050     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720510791050957     Document Type: Article
Times cited : (33)

References (59)
  • 1
    • 44549087765 scopus 로고    scopus 로고
    • Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior
    • Selkoe DJ. Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behav Brain Res 192(1): 106-13 (2008).
    • (2008) Behav Brain Res , vol.192 , Issue.1 , pp. 106-113
    • Selkoe, D.J.1
  • 2
    • 45249108473 scopus 로고    scopus 로고
    • Structure-function implications in Alzheimer's disease: Effect of Abeta oligomers at central synapses
    • Cerpa W, Dinamarca MC, Inestrosa NC. Structure-function implications in Alzheimer's disease: effect of Abeta oligomers at central synapses. Curr Alzheimer Res 5(3): 233-43 (2008).
    • (2008) Curr Alzheimer Res , vol.5 , Issue.3 , pp. 233-243
    • Cerpa, W.1    Dinamarca, M.C.2    Inestrosa, N.C.3
  • 3
    • 58149385218 scopus 로고    scopus 로고
    • Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus
    • Puzzo D, Privitera L, Leznik E, Fà M, Staniszewski A, Palmeri A, et al. Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J Neurosci 28: 14537-14545 (2008).
    • (2008) J Neurosci , vol.28 , pp. 14537-14545
    • Puzzo, D.1    Privitera, L.2    Leznik, E.3    Fà, M.4    Staniszewski, A.5    Palmeri, A.6
  • 4
    • 33947314641 scopus 로고    scopus 로고
    • Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
    • Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci 27: 2866-75 (2007).
    • (2007) J Neurosci , vol.27 , pp. 2866-2875
    • Shankar, G.M.1    Bloodgood, B.L.2    Townsend, M.3    Walsh, D.M.4    Selkoe, D.J.5    Sabatini, B.L.6
  • 5
    • 0035397917 scopus 로고    scopus 로고
    • Novel allosteric antagonists shed light on mGluR5 and CNS disorders
    • Spooren WP, Gasparini F, Salt TE, Kuhn R. Novel allosteric antagonists shed light on mGluR5 and CNS disorders. Trends Pharmacol Sci 22: 331-7 (2001).
    • (2001) Trends Pharmacol Sci , vol.22 , pp. 331-337
    • Spooren, W.P.1    Gasparini, F.2    Salt, T.E.3    Kuhn, R.4
  • 6
    • 0037075138 scopus 로고    scopus 로고
    • Selective antagonists at group I metabotropic glutamate receptors: Synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids
    • Kromann H, Sløk FA, Stensbøl TB, Bräuner-Osborne H, Madsen U, Krogsgaard-Larsen P. Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids. J Med Chem 45(4): 988-91 (2002).
    • (2002) J Med Chem , vol.45 , Issue.4 , pp. 988-991
    • Kromann, H.1    Sløk, F.A.2    Stensbøl, T.B.3    Bräuner-Osborne, H.4    Madsen, U.5    Krogsgaard-Larsen, P.6
  • 7
    • 0030995878 scopus 로고    scopus 로고
    • Pharmacology and functions of metabotropic glutamate receptors
    • Conn PJ, Pin JP. Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 37: 205-37 (1997).
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 205-237
    • Conn, P.J.1    Pin, J.P.2
  • 8
    • 0035371317 scopus 로고    scopus 로고
    • th. Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice
    • th. Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. J Neurosci 21: 3771-9 (2001).
    • (2001) J Neurosci , vol.21 , pp. 3771-3779
    • Karim, F.1    Wang, C.C.2    Gereau, R.W.3
  • 10
    • 10744221298 scopus 로고    scopus 로고
    • Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors
    • Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, et al. Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell 114: 777-89 (2003).
    • (2003) Cell , vol.114 , pp. 777-789
    • Yuan, J.P.1    Kiselyov, K.2    Shin, D.M.3    Chen, J.4    Shcheynikov, N.5    Kang, S.H.6
  • 11
    • 0030704241 scopus 로고    scopus 로고
    • Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1alpha, mGluR2 and mGluR5, relative to neuro-transmitter release sites
    • Lujan R, Roberts JDB, Shigemoto R, Ohishi H, Somogyi P. Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1alpha, mGluR2 and mGluR5, relative to neuro-transmitter release sites. J Chem Neuroanatom 13(4): 219-41 (1997).
    • (1997) J Chem Neuroanatom , vol.13 , Issue.4 , pp. 219-241
    • Lujan, R.1    Roberts, J.D.B.2    Shigemoto, R.3    Ohishi, H.4    Somogyi, P.5
  • 12
    • 0033153034 scopus 로고    scopus 로고
    • Roles of metabotropic glutamate receptors in LTP and LTD in the hippocampus
    • Bortolotto ZA, Fitzjohn SM, Collingridge GL. Roles of metabotropic glutamate receptors in LTP and LTD in the hippocampus. Curr Opin Neurobiol 9: 299-304 (1999).
    • (1999) Curr Opin Neurobiol , vol.9 , pp. 299-304
    • Bortolotto, Z.A.1    Fitzjohn, S.M.2    Collingridge, G.L.3
  • 14
    • 4043114222 scopus 로고    scopus 로고
    • Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation
    • Pacheco R, Ciruela F, Casadó V, Mallol J, Gallart T, Lluis C, et al. Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation. J Biol Chem 279: 33352-8 (2004).
    • (2004) J Biol Chem , vol.279 , pp. 33352-33358
    • Pacheco, R.1    Ciruela, F.2    Casadó, V.3    Mallol, J.4    Gallart, T.5    Lluis, C.6
  • 16
    • 27144537834 scopus 로고    scopus 로고
    • Fenobam: A clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity
    • Porter RH, Jaeschke G, Spooren W, Ballard TM, Büttelmann B, Kolczewski S, et al. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther 315(2): 711-21 (2005).
    • (2005) J Pharmacol Exp Ther , vol.315 , Issue.2 , pp. 711-721
    • Porter, R.H.1    Jaeschke, G.2    Spooren, W.3    Ballard, T.M.4    Büttelmann, B.5    Kolczewski, S.6
  • 17
    • 0033011288 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors prevent programmed cell death through the modulation of neuronal endonuclease activity and intracellular Ph
    • Vincent AM, TenBroeke M, Maiese K. Metabotropic glutamate receptors prevent programmed cell death through the modulation of neuronal endonuclease activity and intracellular Ph. Exp Neurol 155: 79-94 (1999).
    • (1999) Exp Neurol , vol.155 , pp. 79-94
    • Vincent, A.M.1    Tenbroeke, M.2    Maiese, K.3
  • 18
    • 0032993405 scopus 로고    scopus 로고
    • Expression and signaling of group I metabotropic glutamate receptors in astrocytes and microglia
    • Biber K, Laurie DJ, Berthele A, Sommer B, Tölle TR, Gebicke-Härter PJ, et al. Expression and signaling of group I metabotropic glutamate receptors in astrocytes and microglia. J Neurochem 72: 1671-80 (1999).
    • (1999) J Neurochem , vol.72 , pp. 1671-1680
    • Biber, K.1    Laurie, D.J.2    Berthele, A.3    Sommer, B.4    Tölle, T.R.5    Gebicke-Härter, P.J.6
  • 19
    • 0035996447 scopus 로고    scopus 로고
    • Neuronal and glial mGluR5 modulation prevents stretch-induced enhancement of NMDA receptor current
    • Lea PM, Custer SJ, Vicini S, Faden AI. Neuronal and glial mGluR5 modulation prevents stretch-induced enhancement of NMDA receptor current. Pharmacol Biochem Behav 73: 287-98 (2002).
    • (2002) Pharmacol Biochem Behav , vol.73 , pp. 287-298
    • Lea, P.M.1    Custer, S.J.2    Vicini, S.3    Faden, A.I.4
  • 20
    • 0033638723 scopus 로고    scopus 로고
    • Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamatemediated neuronal toxicity through actions that reflect NMDA receptor antagonism
    • O'Leary DM, Movsesyan V, Vicini S, Faden AI. Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamatemediated neuronal toxicity through actions that reflect NMDA receptor antagonism. Br J Pharmacol 131: 1429-37 (2000).
    • (2000) Br J Pharmacol , vol.131 , pp. 1429-1437
    • O'Leary, D.M.1    Movsesyan, V.2    Vicini, S.3    Faden, A.I.4
  • 22
    • 22044444318 scopus 로고    scopus 로고
    • Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors
    • Lea PM, Movsesyan VA, Faden AI. Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors. Br J Pharmacol 145: 527-34 (2005).
    • (2005) Br J Pharmacol , vol.145 , pp. 527-534
    • Lea, P.M.1    Movsesyan, V.A.2    Faden, A.I.3
  • 23
    • 0029147583 scopus 로고
    • Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors
    • Lee RK, Wurtman RJ, Cox AJ, Nitsch RM. Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors. Proc Natl Acad Sci USA 15; 92(17): 8083-7 (1995).
    • (1995) Proc Natl Acad Sci USA 15 , vol.92 , Issue.17 , pp. 8083-8087
    • Lee, R.K.1    Wurtman, R.J.2    Cox, A.J.3    Nitsch, R.M.4
  • 24
    • 3042662255 scopus 로고    scopus 로고
    • mGLuR5 activation reduces [beta]-amyloid-induced cell death in primary neuronal cultures and attenuates translocation of cytochrome c and apoptosis-inducing factor
    • Movsesyan VA, Stoica BA, Faden AI. mGLuR5 activation reduces [beta]-amyloid-induced cell death in primary neuronal cultures and attenuates translocation of cytochrome c and apoptosis-inducing factor. J Neurochem 89(6): 1528-36 (2004).
    • (2004) J Neurochem , vol.89 , Issue.6 , pp. 1528-1536
    • Movsesyan, V.A.1    Stoica, B.A.2    Faden, A.I.3
  • 25
    • 77952492030 scopus 로고    scopus 로고
    • Declines of hippocampal metabotropic glutamate receptor in Alzheimer's disease
    • Minuzzia L, Quiriona R, Gauthiera S, Rosa-Netoa P. Declines of hippocampal metabotropic glutamate receptor in Alzheimer's disease. Alzheimer's Dementia 5(4) (Suppl 1): 267 (2009).
    • (2009) Alzheimer's Dementia , vol.5 , Issue.4 SUPPL. , pp. 267
    • Minuzzia, L.1    Quiriona, R.2    Gauthiera, S.3    Rosa-Netoa, P.4
  • 26
    • 0033019102 scopus 로고    scopus 로고
    • Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-beta peptide. Brain Res (2009); [Epub ahead of Print] [27] Oka A, Takashima S. The up-regulation of metabotropic glutamate receptor 5 (mGluR5) in Down's syndrome brains
    • Casley CS, Lakics V, Lee HG, Broad LM, Day TA, Cluett T, et al. Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-beta peptide. Brain Res (2009); [Epub ahead of Print] [27] Oka A, Takashima S. The up-regulation of metabotropic glutamate receptor 5 (mGluR5) in Down's syndrome brains. Acta Neuropathol 97(3): 275-8 (1999).
    • (1999) Acta Neuropathol , vol.97 , Issue.3 , pp. 275-278
    • Casley, C.S.1    Lakics, V.2    Lee, H.G.3    Broad, L.M.4    Day, T.A.5    Cluett, T.6
  • 27
    • 0001966753 scopus 로고    scopus 로고
    • In: Hagerman RJ, Cronister A, Eds, Baltimore: John Hopkins University Press
    • Hagerman RJ, Hagerman PJ. Physical and behavioral phenotype. In: Hagerman RJ, Cronister A, Eds. Baltimore: John Hopkins University Press pp. 3-109 (2002).
    • (2002) Physical and Behavioral Phenotype , pp. 3-109
    • Hagerman, R.J.1    Hagerman, P.J.2
  • 29
  • 30
    • 0033529082 scopus 로고    scopus 로고
    • Dendritic spine changes associated with hippocampal long-term synaptic plasticity
    • Engert F, Bonhoeffer T. Dendritic spine changes associated with hippocampal long-term synaptic plasticity. Nature 399: 66-70 (1999).
    • (1999) Nature , vol.399 , pp. 66-70
    • Engert, F.1    Bonhoeffer, T.2
  • 31
    • 0037188502 scopus 로고    scopus 로고
    • Altered synaptic plasticity in a mouse model of fragile X mental retardation
    • Huber KM, Gallagher SM, Warren ST, Bear MF. Altered synaptic plasticity in a mouse model of fragile X mental retardation. Proc Natl Acad Sci USA 99: 7746-50 (2002).
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 7746-7750
    • Huber, K.M.1    Gallagher, S.M.2    Warren, S.T.3    Bear, M.F.4
  • 32
    • 65649083055 scopus 로고    scopus 로고
    • Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models
    • Zhang J, Hou L, Klann E, Nelson DL. Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models. J Neurophysiol 101(5): 2572-80 (2009).
    • (2009) J Neurophysiol , vol.101 , Issue.5 , pp. 2572-2580
    • Zhang, J.1    Hou, L.2    Klann, E.3    Nelson, D.L.4
  • 33
    • 70349909566 scopus 로고    scopus 로고
    • Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice
    • Shang Y, Wang H, Mercaldo V, Li X, Chen T, Zhuo M. Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice. J Neurochem 111(3): 635-46 (2009).
    • (2009) J Neurochem , vol.111 , Issue.3 , pp. 635-646
    • Shang, Y.1    Wang, H.2    Mercaldo, V.3    Li, X.4    Chen, T.5    Zhuo, M.6
  • 34
    • 67149099836 scopus 로고    scopus 로고
    • Thin, stubby or mushroom: Spine pathology in Alzheimer's disease
    • Tackenberg C, Ghori A, Brandt R. Thin, stubby or mushroom: spine pathology in Alzheimer's disease. Curr Alzheimer Res 6(3): 261-8 (2009).
    • (2009) Curr Alzheimer Res , vol.6 , Issue.3 , pp. 261-268
    • Tackenberg, C.1    Ghori, A.2    Brandt, R.3
  • 35
    • 0025905795 scopus 로고
    • Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome
    • Verkerk AJ, Pieretti M, Sutcliffe JS, Fu YH, Kuhl DP, Pizzuti A, et al. Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell 65: 905-14 (1991).
    • (1991) Cell , vol.65 , pp. 905-914
    • Verkerk, A.J.1    Pieretti, M.2    Sutcliffe, J.S.3    Fu, Y.H.4    Kuhl, D.P.5    Pizzuti, A.6
  • 36
    • 0026339303 scopus 로고
    • Instability of a 550-base pair DNA segment and abnormal methylation in fragile X syndrome
    • Oberle I, Rousseau F, Heitz D, Kretz C, Devys D, Henauer A, et al. Instability of a 550-base pair DNA segment and abnormal methylation in fragile X syndrome. Science 252: 1097-102 (1991).
    • (1991) Science , vol.252 , pp. 1097-1102
    • Oberle, I.1    Rousseau, F.2    Heitz, D.3    Kretz, C.4    Devys, D.5    Henauer, A.6
  • 37
    • 17844372504 scopus 로고    scopus 로고
    • From mRNP trafficking to spine dysmorphogenesis: The roots of fragile X syndrome
    • Bagni C, Greenough WT. From mRNP trafficking to spine dysmorphogenesis: The roots of fragile X syndrome. Nat Rev Neurosci 6: 376-87 (2005).
    • (2005) Nat Rev Neurosci , vol.6 , pp. 376-387
    • Bagni, C.1    Greenough, W.T.2
  • 38
    • 60849094795 scopus 로고    scopus 로고
    • Phosphorylation of FMRP inhibits association with Dicer
    • Cheever A, Ceman S. Phosphorylation of FMRP inhibits association with Dicer. RNA 15(3): 362-6 (2009).
    • (2009) RNA , vol.15 , Issue.3 , pp. 362-366
    • Cheever, A.1    Ceman, S.2
  • 39
    • 0037423293 scopus 로고    scopus 로고
    • The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses
    • Zalfa F, Giorgi M, Primerano B, Moro A, Di Penta A, Reis S, et al. The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses. Cell 112: 317-27 (2003).
    • (2003) Cell , vol.112 , pp. 317-327
    • Zalfa, F.1    Giorgi, M.2    Primerano, B.3    Moro, A.4    Di Penta, A.5    Reis, S.6
  • 41
    • 0035900649 scopus 로고    scopus 로고
    • Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function
    • Darnell JC, Jensen KB, Jin P, Brown V, Warren ST, Darnell RB, et al. Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell 107: 489-99 (2001).
    • (2001) Cell , vol.107 , pp. 489-499
    • Darnell, J.C.1    Jensen, K.B.2    Jin, P.3    Brown, V.4    Warren, S.T.5    Darnell, R.B.6
  • 42
    • 0042624778 scopus 로고    scopus 로고
    • The fragile X mental retardation protein binds and regulates a novel class of mRNAs containing U rich target sequences
    • Chen L, Yun SW, Seto J, Liu W, Toth M. The fragile X mental retardation protein binds and regulates a novel class of mRNAs containing U rich target sequences. Neuroscience 120: 1005-17 (2003).
    • (2003) Neuroscience , vol.120 , pp. 1005-1017
    • Chen, L.1    Yun, S.W.2    Seto, J.3    Liu, W.4    Toth, M.5
  • 44
    • 53849110899 scopus 로고    scopus 로고
    • Syndrome: Loss of local mrna regulation alters synaptic development and function
    • Bassell GJ, Warren ST, Fragile X. Syndrome: loss of local mrna regulation alters synaptic development and function. Neuron 60(2): 201-14 (2008).
    • (2008) Neuron , vol.60 , Issue.2 , pp. 201-214
    • Bassell, G.J.1    Warren, S.T.2    Fragile, X.3
  • 45
    • 0345492360 scopus 로고    scopus 로고
    • The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor dependent translation of PSD-95
    • Todd P, Mack K, Malter JS. The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor dependent translation of PSD-95. Proc Natl Acad Sci USA 100: 14374-8 (2003).
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 14374-14378
    • Todd, P.1    Mack, K.2    Malter, J.S.3
  • 47
    • 3042647610 scopus 로고    scopus 로고
    • The mGluR theory of fragile X mental retardation
    • Bear MF, Huber KM, Warren ST. The mGluR theory of fragile X mental retardation. Trends Neurosci 27: 370-7 (2004).
    • (2004) Trends Neurosci , vol.27 , pp. 370-377
    • Bear, M.F.1    Huber, K.M.2    Warren, S.T.3
  • 48
    • 65949096495 scopus 로고    scopus 로고
    • A pilot open label, single dose trial of fenobam in adults with fragile X syndrome
    • Berry-Kravis E, Hessl D, Coffey S, Hervey C, Schneider A, Yuhas J, et al. A pilot open label, single dose trial of fenobam in adults with fragile X syndrome. J Med Genet 46(4):266-71 (2009).
    • (2009) J Med Genet , vol.46 , Issue.4 , pp. 266-271
    • Berry-Kravis, E.1    Hessl, D.2    Coffey, S.3    Hervey, C.4    Schneider, A.5    Yuhas, J.6
  • 50
    • 77449134798 scopus 로고    scopus 로고
    • MPEP Reduces Seizure Severity in Fmr-1 KO mice over Expressing Human Abeta
    • Westmark CJ, Westmark PR, Malter JS. MPEP Reduces Seizure Severity in Fmr-1 KO mice over Expressing Human Abeta. Int J Clin Exp Pathol 10; 3(1): 56-68 (2009).
    • (2009) Int J Clin Exp Pathol 10 , vol.3 , Issue.1 , pp. 56-68
    • Westmark, C.J.1    Westmark, P.R.2    Malter, J.S.3
  • 51
    • 0035801393 scopus 로고    scopus 로고
    • The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif
    • Schaeffer C, Bardoni B, Mandel JL, Ehresmann B, Ehresmann C, Moine H, et al. The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif. EMBO J 20: 4803-13 (2001).
    • (2001) EMBO J , vol.20 , pp. 4803-4813
    • Schaeffer, C.1    Bardoni, B.2    Mandel, J.L.3    Ehresmann, B.4    Ehresmann, C.5    Moine, H.6
  • 52
    • 0025784589 scopus 로고
    • Distribution and activity of alternatively spliced Alzheimer amyloid peptide precursor and scrapie PrP mRNAs on rat brain polysomes
    • Denman R, Potempska A, Wolfe G, Ramakrishna N, Miller DL. Distribution and activity of alternatively spliced Alzheimer amyloid peptide precursor and scrapie PrP mRNAs on rat brain polysomes. Arch Biochem Biophys 288: 29-38 (1991).
    • (1991) Arch Biochem Biophys , vol.288 , pp. 29-38
    • Denman, R.1    Potempska, A.2    Wolfe, G.3    Ramakrishna, N.4    Miller, D.L.5
  • 54
    • 33947195786 scopus 로고    scopus 로고
    • FMRP mediates mGluR5-dependent translation of amyloid precursor protein
    • Westmark CJ, Malter JS. FMRP mediates mGluR5-dependent translation of amyloid precursor protein. PLoS Biol 5(3): e52 (2007).
    • (2007) PLoS Biol , vol.5 , Issue.3
    • Westmark, C.J.1    Malter, J.S.2
  • 56
    • 31344432963 scopus 로고    scopus 로고
    • Phenyl ureas of creatinine as mGluR5 antagonists. A structure-activity relationship study of fenobam analogues
    • Wållberg A, Nilsson K, Osterlund K, Peterson A, Elg S, Raboisson P, et al. Phenyl ureas of creatinine as mGluR5 antagonists. A structure-activity relationship study of fenobam analogues. Bioorg Med Chem Lett 16(5): 1142-5 (2006).
    • (2006) Bioorg Med Chem Lett , vol.16 , Issue.5 , pp. 1142-1145
    • Wållberg, A.1    Nilsson, K.2    Osterlund, K.3    Peterson, A.4    Elg, S.5    Raboisson, P.6
  • 57
    • 67650455900 scopus 로고    scopus 로고
    • The anxiolytic and analgesic properties of fenobam, a potent mGlu5 receptor antagonist, in relation to the impairment of learning
    • doi:10.1016/j.neuropharm
    • Jacob W, Gravius A, Pietraszek M, Nagel J, Belozertseva I, Shekunova E. The anxiolytic and analgesic properties of fenobam, a potent mGlu5 receptor antagonist, in relation to the impairment of learning. Neuropharmacology doi:10.1016/j.neuropharm.2009.04. 011 (2009).
    • (2009) Neuropharmacology , vol.4 , Issue.11 , pp. 2009
    • Jacob, W.1    Gravius, A.2    Pietraszek, M.3    Nagel, J.4    Belozertseva, I.5    Shekunova, E.6
  • 58
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, A elevation, and amyloid plaques in transgenic mice
    • Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, et al. Correlative memory deficits, A elevation, and amyloid plaques in transgenic mice. Science 274: 99-102 (1996).
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3    Eckman, C.4    Harigaya, Y.5    Younkin, S.6
  • 59
    • 9844219728 scopus 로고    scopus 로고
    • Altered metabolism of familial Alzheimer's disease linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice
    • Lamb BT, Call LM, Slunt HH, Bardel KA, Lawler AM, Eckman CB, et al. Altered metabolism of familial Alzheimer's disease linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice. Hum Mol Genet 6: 1535-41 (1997).
    • (1997) Hum Mol Genet , vol.6 , pp. 1535-1541
    • Lamb, B.T.1    Call, L.M.2    Slunt, H.H.3    Bardel, K.A.4    Lawler, A.M.5    Eckman, C.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.