-
1
-
-
84855691031
-
Central adaptation to odorants depends on PI3K levels in local interneurons of the antennal lobe
-
doi: 10.1523/JNEUROSCI.2921-11.2012
-
Acebes, A., Devaud, J. M., Arnes, M., and Ferrus, A. (2012). Central adaptation to odorants depends on PI3K levels in local interneurons of the antennal lobe. J. Neurosci. 32,417-422. doi: 10.1523/JNEUROSCI.2921-11.2012.
-
(2012)
J. Neurosci
, vol.32
, pp. 417-422
-
-
Acebes, A.1
Devaud, J.M.2
Arnes, M.3
Ferrus, A.4
-
2
-
-
79951989692
-
Synapse loss in olfactorylocal interneurons modifies perception
-
doi: 10.1523/JNEUR0SCI.5046-10.2011
-
Acebes, A., Martin-Pena, A., Chevalier, V., and Ferrus, A. (2011). Synapse loss in olfactorylocal interneurons modifies perception. J. Neurosci. 31,2734-2745. doi: 10.1523/JNEUR0SCI.5046-10.2011.
-
(2011)
J. Neurosci
, vol.31
, pp. 2734-2745
-
-
Acebes, A.1
Martin-Pena, A.2
Chevalier, V.3
Ferrus, A.4
-
3
-
-
84887942578
-
Phosphatidylinos-itol 3-kinase (PI3K) inhibitors as cancer therapeutics
-
doi: 10.1186/1756-8722-6-88
-
Akinleye, A., Avvaru, P., Furqan, M., Song, Y., and Liu, D. (2013). Phosphatidylinos-itol 3-kinase (PI3K) inhibitors as cancer therapeutics. J. Hematol. Oncol. 6, 88. doi: 10.1186/1756-8722-6-88.
-
(2013)
J. Hematol. Oncol
, vol.6
, pp. 88
-
-
Akinleye, A.1
Avvaru, P.2
Furqan, M.3
Song, Y.4
Liu, D.5
-
4
-
-
84887824378
-
Phosphoinositide 3-Kinase deltagene mutation predisposes to respiratory infectionandairwaydamage
-
doi: 10.1126/science.1243292
-
Angulo, I., Vadas, O., Garcon, F., Banham-Hall, E., Plagnol, V., Leahy, T. R., et al. (2013). Phosphoinositide 3-Kinase deltagene mutation predisposes to respiratory infectionandairwaydamage. Science 342, 866-871. doi: 10.1126/science.1243292.
-
(2013)
Science
, vol.342
, pp. 866-871
-
-
Angulo, I.1
Vadas, O.2
Garcon, F.3
Banham-Hall, E.4
Plagnol, V.5
Leahy, T.R.6
-
5
-
-
0036185944
-
Early embryonic lethalityin mice deficient in thep110beta catalytic subunit ofPI 3-kinase
-
doi: 10.1007/s00335-001-2123-x
-
Bi, L., Okabe, I., Bernard, D. J., and Nussbaum, R. L. (2002). Early embryonic lethalityin mice deficient in thep110beta catalytic subunit ofPI 3-kinase. Mamm. Genome 13, 169-172. doi: 10.1007/s00335-001-2123-x
-
(2002)
Mamm. Genome
, vol.13
, pp. 169-172
-
-
Bi, L.1
Okabe, I.2
Bernard, D.J.3
Nussbaum, R.L.4
-
6
-
-
79960555700
-
Possible implications of insulin resistance and glucose metabolism in Alzheimer's disease pathogenesis
-
doi: 10.1111/j.1582-4934.2011.01318.x
-
Bosco, D., Fava, A., Plastino, M., Montalcini, T., and Pujia, A. (2011). Possible implications of insulin resistance and glucose metabolism in Alzheimer's disease pathogenesis. J. Cell. Mol. Med. 15, 1807-1821. doi: 10.1111/j.1582-4934.2011.01318.x
-
(2011)
J. Cell. Mol. Med
, vol.15
, pp. 1807-1821
-
-
Bosco, D.1
Fava, A.2
Plastino, M.3
Montalcini, T.4
Pujia, A.5
-
7
-
-
84879732033
-
Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death
-
doi: 10.1038/cddis.2013.111
-
Brennan-Minnella, A. M., Shen, Y., El-Benna, J., and Swanson, R. A. (2013). Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death. CellDeath Dis. 4, e580. doi: 10.1038/cddis.2013.111
-
(2013)
CellDeath Dis
, vol.4
-
-
Brennan-Minnella, A.M.1
Shen, Y.2
El-Benna, J.3
Swanson, R.A.4
-
8
-
-
24744435115
-
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
-
doi: 10.1038/nm1284
-
Camps, M., Ruckle, T., Ji, H., Ardissone, V., Rintelen, F., Shaw, J., et al. (2005). Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat. Med. 11, 936-943. doi: 10.1038/nm1284.
-
(2005)
Nat. Med
, vol.11
, pp. 936-943
-
-
Camps, M.1
Ruckle, T.2
Ji, H.3
Ardissone, V.4
Rintelen, F.5
Shaw, J.6
-
9
-
-
77649341620
-
PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development
-
doi: 10.1038/emboj.2009.406
-
Chan, C.-B., Liu, X., Ensslin, M. A., Dillehay, D. L., Ormandy, C. J., Sohn, P., et al. (2010). PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development. EMBO J. 29, 956-968. doi: 10.1038/emboj.2009.406.
-
(2010)
EMBO J
, vol.29
, pp. 956-968
-
-
Chan, C.-B.1
Liu, X.2
Ensslin, M.A.3
Dillehay, D.L.4
Ormandy, C.J.5
Sohn, P.6
-
10
-
-
77954480424
-
PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons
-
doi: 10.1523/jneurosci.6271-09.2010
-
Christie, K. J., Webber, C. A., Martinez, J. A., Singh, B., and Zochodne, D. W. (2010). PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons. J. Neurosci. 30, 9306-9315. doi: 10.1523/jneurosci.6271-09.2010.
-
(2010)
J. Neurosci
, vol.30
, pp. 9306-9315
-
-
Christie, K.J.1
Webber, C.A.2
Martinez, J.A.3
Singh, B.4
Zochodne, D.W.5
-
11
-
-
79951990962
-
Phosphoinositide-3-kinase activation controls synaptogene-sis and spinogenesis in hippocampal neurons
-
doi: 10.1523/JNEUROSCI.4477-10.2011
-
Cuesto, G., Enriquez-Barreto, L., Carames, C., Cantarero, M., Gasull, X., Sandi, C., et al. (2011). Phosphoinositide-3-kinase activation controls synaptogene-sis and spinogenesis in hippocampal neurons. J. Neurosci. 31, 2721-2733. doi: 10.1523/JNEUROSCI.4477-10.2011.
-
(2011)
J. Neurosci
, vol.31
, pp. 2721-2733
-
-
Cuesto, G.1
Enriquez-Barreto, L.2
Carames, C.3
Cantarero, M.4
Gasull, X.5
Sandi, C.6
-
12
-
-
65449139457
-
Autism-specific copy number variants further implicate the phosphatidylinositol signaling pathway and the glutamatergic synapse in the etiology of the disorder
-
doi: 10.1093/hmg/ddp092
-
Cusco, I., Medrano, A., Gener, B., Vilardell, M., Gallastegui, F., Villa, O., et al. (2009). Autism-specific copy number variants further implicate the phosphatidylinositol signaling pathway and the glutamatergic synapse in the etiology of the disorder. Hum. Mol. Genet. 18, 1795-1804. doi: 10.1093/hmg/ddp092.
-
(2009)
Hum. Mol. Genet
, vol.18
, pp. 1795-1804
-
-
Cusco, I.1
Medrano, A.2
Gener, B.3
Vilardell, M.4
Gallastegui, F.5
Villa, O.6
-
13
-
-
79960779323
-
FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
-
doi: 10.1016/j.cell.2011.06.013
-
Darnell, J. C., Van Driesche, S. J., Zhang, C., Hung, K. Y., Mele, A., Fraser, C. E., et al. (2011). FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism. Cell 146, 247-261. doi: 10.1016/j.cell.2011.06.013.
-
(2011)
Cell
, vol.146
, pp. 247-261
-
-
Darnell, J.C.1
van Driesche, S.J.2
Zhang, C.3
Hung, K.Y.4
Mele, A.5
Fraser, C.E.6
-
14
-
-
78650529784
-
A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase
-
doi: 10.1073/pnas.1008739107
-
Dbouk, H. A., Pang, H., Fiser, A., and Backer, J. M. (2010). A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase. Proc. Natl. Acad. Sci. U.S.A. 107, 19897-19902. doi: 10.1073/pnas.1008739107
-
(2010)
Proc. Natl. Acad. Sci. U.S.A
, vol.107
, pp. 19897-19902
-
-
Dbouk, H.A.1
Pang, H.2
Fiser, A.3
Backer, J.M.4
-
15
-
-
84889001107
-
Intranasal insulin therapy for cognitive impairment and neurodegeneration: Current state of the art. Expert Opin
-
doi: 10.1517/17425247.2013.856877
-
de la Monte, S. M. (2013). Intranasal insulin therapy for cognitive impairment and neurodegeneration: current state of the art. Expert Opin. Drug Deliv. 10, 1699-1709. doi: 10.1517/17425247.2013.856877.
-
(2013)
Drug Deliv
, vol.10
, pp. 1699-1709
-
-
de la Monte, S.M.1
-
16
-
-
0030790548
-
Using structure to define the function of phosphoinositide 3-kinase family members
-
doi: 10.1016/S0014-5793(97)00617-0
-
Domin, J., and Waterfield, M. D. (1997). Using structure to define the function of phosphoinositide 3-kinase family members. FEBS Lett. 410, 91-95. doi: 10.1016/S0014-5793(97)00617-0.
-
(1997)
FEBS Lett
, vol.410
, pp. 91-95
-
-
Domin, J.1
Waterfield, M.D.2
-
17
-
-
41149165141
-
Control of axonal growth and regeneration of sensory neurons by the p110§ PI 3-kinase
-
doi: 10.1371/journal.pone.00 00869
-
Eickholt, B. J., Ahmed, A. I., Davies, M., Papakonstanti, E. A., Pearce, W., Starkey, M. L., et al. (2007). Control of axonal growth and regeneration of sensory neurons by the p110§ PI 3-kinase. PLoS ONE 2:e869. doi: 10.1371/journal.pone.00 00869
-
(2007)
PLoS ONE
, vol.2
-
-
Eickholt, B.J.1
Ahmed, A.I.2
Davies, M.3
Papakonstanti, E.A.4
Pearce, W.5
Starkey, M.L.6
-
18
-
-
78650818650
-
Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway
-
doi: 10.1007/82_2010_58
-
Fayard, E., Xue, G., Parcellier, A., Bozulic, L., and Hemmings, B. A. (2010). Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway. Curr. Top. Microbiol. Immunol. 346, 31-56. doi: 10.1007/82_2010_58.
-
(2010)
Curr. Top. Microbiol. Immunol
, vol.346
, pp. 31-56
-
-
Fayard, E.1
Xue, G.2
Parcellier, A.3
Bozulic, L.4
Hemmings, B.A.5
-
19
-
-
77954903710
-
Activity of any class IA PI3K isoform can sustain cell proliferation and survival
-
doi: 10.1073/pnas.09064 61107
-
Foukas, L. C., Berenjeno, I. M., Gray, A., Khwaja, A., and Vanhaesebroeck, B. (2010).Activity of any class IA PI3K isoform can sustain cell proliferation and survival. Proc. Natl. Acad. Sci. U.S.A. 107, 11381-11386. doi: 10.1073/pnas.09064 61107
-
(2010)
Proc. Natl. Acad. Sci. U.S.A
, vol.107
, pp. 11381-11386
-
-
Foukas, L.C.1
Berenjeno, I.M.2
Gray, A.3
Khwaja, A.4
Vanhaesebroeck, B.5
-
20
-
-
84880555817
-
Intranasal insulin as a treatment for Alzheimer's disease: A review of basic research and clinical evidence
-
doi: 10.1007/s40263-013-0076-8
-
Freiherr, J., Hallschmid, M., Frey, W. H. II, Brunner, Y. F., Chapman, C. D., Holscher, C., et al. (2013). Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence. CNS Drugs 27, 505-514. doi: 10.1007/s40263-013-0076-8.
-
(2013)
CNS Drugs
, vol.27
, pp. 505-514
-
-
Freiherr, J.1
Hallschmid, M.2
Frey, W.H.I.I.3
Brunner, Y.F.4
Chapman, C.D.5
Holscher, C.6
-
21
-
-
84878288766
-
RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms
-
doi: 10.1016/j.cell.2013.04.031
-
Fritsch, R., dekrijger, I., Fritsch, K., George, R., Reason, B., Kumar, MS., et al. (2013). RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms. Cell 153, 1050-1063. doi: 10.1016/j.cell.2013.04.031.
-
(2013)
Cell
, vol.153
, pp. 1050-1063
-
-
Fritsch, R.1
Dekrijger, I.2
Fritsch, K.3
George, R.4
Reason, B.5
Kumar, M.S.6
-
22
-
-
80052275615
-
PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains
-
doi: 10.1073/pnas.1019386108
-
Gao, X., Lowry, P. R., Zhou, X., Depry, C., Wei, Z., Wong, G. W., et al. (2011).PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains. Proc. Natl. Acad. Sci. U.S.A. 108, 14509-14514. doi: 10.1073/pnas.1019386108
-
(2011)
Proc. Natl. Acad. Sci. U.S.A
, vol.108
, pp. 14509-14514
-
-
Gao, X.1
Lowry, P.R.2
Zhou, X.3
Depry, C.4
Wei, Z.5
Wong, G.W.6
-
23
-
-
84860568814
-
Excess protein synthesis in FXS patient lym-phoblastoid cells can be rescued with a p110beta-selective inhibitor
-
doi: 10.2119/molmed.2011.00363
-
Gross, C., and Bassell, G. J. (2012). Excess protein synthesis in FXS patient lym-phoblastoid cells can be rescued with a p110beta-selective inhibitor. Mol. Med. 18, 336-345. doi: 10.2119/molmed.2011.00363.
-
(2012)
Mol. Med
, vol.18
, pp. 336-345
-
-
Gross, C.1
Bassell, G.J.2
-
24
-
-
77956209418
-
Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome
-
doi: 10.1523/JNEUROSCI.0402-10.2010
-
Gross, C., Nakamoto, M., Yao, X., Chan, C. B., Yim, S. Y., Ye, K., et al. (2010). Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome. J. Neurosci. 30, 10624-10638. doi: 10.1523/JNEUROSCI.0402-10.2010.
-
(2010)
J. Neurosci
, vol.30
, pp. 10624-10638
-
-
Gross, C.1
Nakamoto, M.2
Yao, X.3
Chan, C.B.4
Yim, S.Y.5
Ye, K.6
-
25
-
-
46149106818
-
The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma
-
doi: 10.1073/pnas.0707761105
-
Guillermet-Guibert, J., Bjorklof, K., Salpekar, A., Gonella, C., Ramadani, F., Bilancio, A., et al. (2008). The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma. Proc. Natl. Acad. Sci. U.S.A. 105, 8292-8297. doi: 10.1073/pnas.0707761105.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A
, vol.105
, pp. 8292-8297
-
-
Guillermet-Guibert, J.1
Bjorklof, K.2
Salpekar, A.3
Gonella, C.4
Ramadani, F.5
Bilancio, A.6
-
26
-
-
70149087158
-
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia
-
doi: 10.1182/blood-2009-02-r)(\c,ir)r)
-
Gutierrez, A., Sanda, T., Grebliunaite, R., Carracedo, A., Salmena, L., Ahn, Y., et al. (2009). High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood 114, 647-650. doi: 10.1182/blood-2009-02-r)(\c,ir)r)
-
(2009)
Blood
, vol.114
, pp. 647-650
-
-
Gutierrez, A.1
Sanda, T.2
Grebliunaite, R.3
Carracedo, A.4
Salmena, L.5
Ahn, Y.6
-
27
-
-
33751297031
-
Signalling through Class I PI3Ks in mammalian cells
-
doi: 10.1042/BST0340647
-
Hawkins, P. T., Anderson, K. E., Davidson, K., and Stephens, L. R. (2006). Signalling through Class I PI3Ks in mammalian cells. Biochem. Soc. Trans. 34, 647-662. doi: 10.1042/BST0340647.
-
(2006)
Biochem. Soc. Trans
, vol.34
, pp. 647-662
-
-
Hawkins, P.T.1
Anderson, K.E.2
Davidson, K.3
Stephens, L.R.4
-
28
-
-
75749114797
-
mTORsignaling: At the crossroads of plasticity, memory and disease
-
doi: 10.1016/j.tins.2009.11.003
-
Hoeffer, C.A., and Klann, E. (2010). mTORsignaling: at the crossroads of plasticity, memory and disease. Trends Neurosci. 33, 67-75. doi: 10.1016/j.tins.2009.11.003.
-
(2010)
Trends Neurosci
, vol.33
, pp. 67-75
-
-
Hoeffer, C.A.1
Klann, E.2
-
29
-
-
1842562359
-
An investigation into signal transduction mechanisms involved in insulin-induced long-term depression in the CA1 region of the hippocampus
-
doi: 10.1111/j.1471-4159.2003.02307.x
-
Huang, C.-C., Lee, C.-C., and Hsu, K.-S. (2004). An investigation into signal transduction mechanisms involved in insulin-induced long-term depression in the CA1 region of the hippocampus. J. Neurochem. 89, 217-231. doi: 10.1111/j.1471-4159.2003.02307.x
-
(2004)
J. Neurochem
, vol.89
, pp. 217-231
-
-
Huang, C.-C.1
Lee, C.-C.2
Hsu, K.-S.3
-
30
-
-
0344305401
-
Insulin induces a novel form of postsynaptic mossy fiber long-term depression in the hippocampus
-
doi: 10.1016/S1044-7431(03)00238-0
-
Huang, C.-C., You, J.-L., Lee, C.-C., and Hsu, K.-S. (2003). Insulin induces a novel form of postsynaptic mossy fiber long-term depression in the hippocampus. Mol. Cell. Neurosci. 24, 831-841. doi: 10.1016/S1044-7431(03)00238-0.
-
(2003)
Mol. Cell. Neurosci
, vol.24
, pp. 831-841
-
-
Huang, C.-C.1
You, J.-L.2
Lee, C.-C.3
Hsu, K.-S.4
-
31
-
-
0036713778
-
TSC2 is phosphorylated and inhibited byAkt and suppresses mTORsignalling
-
doi: 10.1038/ncb839
-
Inoki, K., Li, Y., Zhu, T., Wu, J., and Guan, K.-L. (2002). TSC2 is phosphorylated and inhibited byAkt and suppresses mTORsignalling. Nat. Cell Biol. 4, 648-657. doi: 10.1038/ncb839
-
(2002)
Nat. Cell Biol
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.-L.5
-
32
-
-
0035871209
-
Further characterization of the autism susceptibility locus AUTS1 on chromosome 7q
-
International Molecular Genetic Study of Autism Consortium, doi: 10.1093/hmg/10.9.973
-
International Molecular Genetic Study of Autism Consortium. (2001). Further characterization of the autism susceptibility locus AUTS1 on chromosome 7q. Hum. Mol. Genet. 10,973-982.doi: 10.1093/hmg/10.9.973.
-
(2001)
Hum. Mol. Genet
, vol.10
, pp. 973-982
-
-
-
33
-
-
30544449810
-
Control of dendritic arborization by the phosphoinositide-37-kinase-Akt-mammalian target of rapamycin pathway
-
doi: 10.1523/JNEUROSCI.2270-05.2005
-
Jaworski, J., Spangler, S., Seeburg, D. P., Hoogenraad, C. C., and Sheng, M. (2005). Control of dendritic arborization by the phosphoinositide-37-kinase-Akt-mammalian target of rapamycin pathway. J. Neurosci. 25, 11300-11312. doi: 10.1523/JNEUROSCI.2270-05.2005.
-
(2005)
J. Neurosci
, vol.25
, pp. 11300-11312
-
-
Jaworski, J.1
Spangler, S.2
Seeburg, D.P.3
Hoogenraad, C.C.4
Sheng, M.5
-
34
-
-
49649087385
-
Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis
-
doi: 10.1038/nature07091
-
Jia, S., Liu, Z., Zhang, S., Liu, P., Zhang, L., Lee, S. H., et al. (2008). Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature 454, 776-779. doi: 10.1038/nature07091.
-
(2008)
Nature
, vol.454
, pp. 776-779
-
-
Jia, S.1
Liu, Z.2
Zhang, S.3
Liu, P.4
Zhang, L.5
Lee, S.H.6
-
35
-
-
0037695593
-
Essential, nonredundant role for the phosphoinositide 3-kinase p1105 in signaling by the B-cell receptor complex
-
doi: 10.1128/mcb.22.24.8580-8591.2002
-
Jou, S.-T., Carpino, N., Takahashi, Y., Piekorz, R., Chao, J.-R., Carpino, N., et al. (2002). Essential, nonredundant role for the phosphoinositide 3-kinase p1105 in signaling by the B-cell receptor complex. Mol. Cell. Biol. 22, 8580-8591. doi: 10.1128/mcb.22.24.8580-8591.2002.
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 8580-8591
-
-
Jou, S.-T.1
Carpino, N.2
Takahashi, Y.3
Piekorz, R.4
Chao, J.-R.5
Carpino, N.6
-
36
-
-
32644480629
-
The role of the phosphatidylinositide 3-kinase-protein kinase B pathway in schizophrenia
-
doi: 10.1016/j.pharmthera.2005.10.014
-
Kalkman, H. O. (2006). The role of the phosphatidylinositide 3-kinase-protein kinase B pathway in schizophrenia. Pharmacol. Ther. 110, 117-134. doi: 10.1016/j.pharmthera.2005.10.014.
-
(2006)
Pharmacol. Ther
, vol.110
, pp. 117-134
-
-
Kalkman, H.O.1
-
37
-
-
31944448780
-
Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase
-
doi: 10.1073/pnas.0510772103
-
Kang, S., Denley, A., Vanhaesebroeck, B., and Vogt, P. K. (2006). Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase. Proc. Natl. Acad. Sci. U.S.A. 103, 1289-1294. doi: 10.1073/pnas.0510772103.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A
, vol.103
, pp. 1289-1294
-
-
Kang, S.1
Denley, A.2
Vanhaesebroeck, B.3
Vogt, P.K.4
-
38
-
-
77955274106
-
Signaling pathways in schizophrenia: Emerging targets and therapeutic strategies
-
doi: 10.1016/j.tips.2010.05.004
-
Karam, C. S., Ballon, J. S., Bivens, N. M., Freyberg, Z., Girgis, R. R., Lizardi-Ortiz, J. E., et al. (2010). Signaling pathways in schizophrenia: emerging targets and therapeutic strategies. Trends Pharmacol. Sci. 31, 381-390. doi: 10.1016/j.tips.2010.05.004.
-
(2010)
Trends Pharmacol. Sci
, vol.31
, pp. 381-390
-
-
Karam, C.S.1
Ballon, J.S.2
Bivens, N.M.3
Freyberg, Z.4
Girgis, R.R.5
Lizardi-Ortiz, J.E.6
-
39
-
-
80054977111
-
PI3Kgamma is required for NMDA receptor-dependent long-term depression and behavioral flexibility
-
doi: 10.1038/nn.2937
-
Kim, J. I., Lee, H. R., Sim, S. E., Baek, J., Yu, N. K., Choi, J. H., et al. (2011). PI3Kgamma is required for NMDA receptor-dependent long-term depression and behavioral flexibility. Nat. Neurosci. 14, 1447-1454. doi: 10.1038/nn.2937.
-
(2011)
Nat. Neurosci
, vol.14
, pp. 1447-1454
-
-
Kim, J.I.1
Lee, H.R.2
Sim, S.E.3
Baek, J.4
Yu, N.K.5
Choi, J.H.6
-
40
-
-
84890805572
-
Low glycaemic index diet reduces seizure susceptibilityinasyndrome-specific mouse model of generalized epilepsy
-
doi: 10.1016/j.eplepsyres.2013.10.014
-
Kim, T. H., Petrou, S., and Reid, C. A. (2013). Low glycaemic index diet reduces seizure susceptibilityinasyndrome-specific mouse model of generalized epilepsy. Epilepsy Res. doi: 10.1016/j.eplepsyres.2013.10.014.
-
(2013)
Epilepsy Res
-
-
Kim, T.H.1
Petrou, S.2
Reid, C.A.3
-
41
-
-
33646383684
-
A pharmacological map of the PI3-K family defines a role for p110 ± in insulin signaling
-
doi: 10.1016/j.cell.2006.03.035
-
Knight, Z. A., Gonzalez, B., Feldman, M. E., Zunder, E. R., Goldenberg, D. D., Williams, O., et al. (2006). A pharmacological map of the PI3-K family defines a role for p110 ± in insulin signaling. Cell 125, 733-747. doi: 10.1016/j.cell.2006.03.035.
-
(2006)
Cell
, vol.125
, pp. 733-747
-
-
Knight, Z.A.1
Gonzalez, B.2
Feldman, M.E.3
Zunder, E.R.4
Goldenberg, D.D.5
Williams, O.6
-
42
-
-
84878759104
-
Mouse models of PIK3CA mutations: One mutation initiates heterogeneous mammarytumors
-
doi: 10.1111/febs.12175
-
Koren, S., and Bentires-Alj, M. (2013). Mouse models of PIK3CA mutations: one mutation initiates heterogeneous mammarytumors. FEBS J. 280,2758-2765. doi: 10.1111/febs.12175
-
(2013)
FEBS J
, vol.280
, pp. 2758-2765
-
-
Koren, S.1
Bentires-Alj, M.2
-
43
-
-
0036090377
-
Genomic structure of the PIK3CG gene on chromosome band 7q22 and evaluation as a candidate myeloid tumor suppressor
-
doi: 10.1182/blood.V99.1.372
-
Kratz, C. P., Emerling, B. M., Bonifas, J., Wang, W., Green, E. D., Beau, M. M. L., et al. (2002). Genomic structure of the PIK3CG gene on chromosome band 7q22 and evaluation as a candidate myeloid tumor suppressor. Blood 99, 372-374. doi: 10.1182/blood.V99.1.372.
-
(2002)
Blood
, vol.99
, pp. 372-374
-
-
Kratz, C.P.1
Emerling, B.M.2
Bonifas, J.3
Wang, W.4
Green, E.D.5
Beau, M.M.L.6
-
44
-
-
84890806945
-
Everolimus treatment of refractory epilepsy in tuberous sclerosis complex
-
doi: 10.1002/ana.23960
-
Krueger, D. A., Wilfong, A. A., Holland-Bouley, K., Anderson, A. E., Agricola, K., Tudor, C., et al. (2013). Everolimus treatment of refractory epilepsy in tuberous sclerosis complex. Ann. Neurol. 74, 679-687. doi: 10.1002/ana.23960.
-
(2013)
Ann. Neurol
, vol.74
, pp. 679-687
-
-
Krueger, D.A.1
Wilfong, A.A.2
Holland-Bouley, K.3
Anderson, A.E.4
Agricola, K.5
Tudor, C.6
-
45
-
-
0034912213
-
Association of phosphatidylinositol 3-kinase composed of p110beta-catalytic and p85-regulatory subunits with the small GTPase Rab5
-
doi: 10.1093/oxfordjour-nals.jbchem.a002964
-
Kurosu, H., and Katada, T. (2001). Association of phosphatidylinositol 3-kinase composed of p110beta-catalytic and p85-regulatory subunits with the small GTPase Rab5. J. Biochem. 130, 73-78. doi: 10.1093/oxfordjour-nals.jbchem.a002964.
-
(2001)
J. Biochem
, vol.130
, pp. 73-78
-
-
Kurosu, H.1
Katada, T.2
-
46
-
-
0030869757
-
Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110beta is synergistically activated by the betagamma subunits of G proteins and phosphotyrosyl peptide
-
doi: 10.1074/jbc.272.39.24252
-
Kurosu, H., Maehama, T., Okada, T., Yamamoto, T., Hoshino, S., Fukui, Y., et al. (1997). Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110beta is synergistically activated by the betagamma subunits of G proteins and phosphotyrosyl peptide. J. Biol. Chem. 272, 24252-24256. doi: 10.1074/jbc.272.39.24252
-
(1997)
J. Biol. Chem
, vol.272
, pp. 24252-24256
-
-
Kurosu, H.1
Maehama, T.2
Okada, T.3
Yamamoto, T.4
Hoshino, S.5
Fukui, Y.6
-
47
-
-
33846589304
-
Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia
-
doi: 10.1093/hmg/ddl449
-
Law, A. J., Kleinman, J. E., Weinberger, D. R., and Weickert, C. S. (2007). Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia. Hum. Mol. Genet. 16, 129-141. doi: 10.1093/hmg/ddl449.
-
(2007)
Hum. Mol. Genet
, vol.16
, pp. 129-141
-
-
Law, A.J.1
Kleinman, J.E.2
Weinberger, D.R.3
Weickert, C.S.4
-
48
-
-
33646240854
-
Neuregulin 1 transcripts are differentiallyexpressedin schizophrenia and regulated by 57. SNPs associated with the disease
-
doi: 10.1073/pnas.0602002103
-
Law, A. J., Lipska, B. K., Weickert, C. S., Hyde, T. M., Straub, R. E., Hashimoto, R., et al. (2006). Neuregulin 1 transcripts are differentiallyexpressedin schizophrenia and regulated by 57. SNPs associated with the disease. Proc. Natl. Acad. Sci. U.S.A. 103, 6747-6752. doi: 10.1073/pnas.0602002103.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A
, vol.103
, pp. 6747-6752
-
-
Law, A.J.1
Lipska, B.K.2
Weickert, C.S.3
Hyde, T.M.4
Straub, R.E.5
Hashimoto, R.6
-
49
-
-
84864340439
-
Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110delta inhibition as a potential therapeutic strategy
-
doi: 10.1073/pnas.1206118109
-
Law, A. J., Wang, Y., Sei, Y., O'Donnell, P., Piantadosi, P., Papaleo, F., et al. (2012). Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110delta inhibition as a potential therapeutic strategy. Proc. Natl. Acad. Sci. U.S.A. 109,12165-12170. doi: 10.1073/pnas.1206118109.
-
(2012)
Proc. Natl. Acad. Sci. U.S.A
, vol.109
, pp. 12165-12170
-
-
Law, A.J.1
Wang, Y.2
Sei, Y.3
O'Donnell, P.4
Piantadosi, P.5
Papaleo, F.6
-
50
-
-
79960016949
-
Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways
-
doi: 10.1016/j.neuropharm.2011.06.003
-
Lee, C.-C., Huang, C.-C., and Hsu, K.-S. (2011). Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways. Neuropharmacology 61, 867-879. doi: 10.1016/j.neuropharm.2011.06.003.
-
(2011)
Neuropharmacology
, vol.61
, pp. 867-879
-
-
Lee, C.-C.1
Huang, C.-C.2
Hsu, K.-S.3
-
51
-
-
84864402732
-
De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly
-
doi: 10.1038/ng.2329
-
Lee, J. H., Huynh, M., Silhavy, J. L., Kim, S., Dixon-Salazar, T., Heiberg, A., et al. (2012). De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly. Nat. Genet. 44, 941-945. doi: 10.1038/ng.2329
-
(2012)
Nat. Genet
, vol.44
, pp. 941-945
-
-
Lee, J.H.1
Huynh, M.2
Silhavy, J.L.3
Kim, S.4
Dixon-Salazar, T.5
Heiberg, A.6
-
52
-
-
84872115717
-
Pleckstrin homology (PH) domains and phosphoinositides
-
doi: 10.1042/BSS0740081
-
Lemmon, M. A. (2007). Pleckstrin homology (PH) domains and phosphoinositides. Biochem. Soc. Symp. 81-93. doi: 10.1042/BSS0740081.
-
(2007)
Biochem. Soc. Symp
, pp. 81-93
-
-
Lemmon, M.A.1
-
53
-
-
65249140471
-
The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders
-
doi: 10.1172/JCI37934
-
Levitt, P., and Campbell, D. B. (2009). The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders. J. Clin. Invest. 119,747-754. doi: 10.1172/JCI37934.
-
(2009)
J. Clin. Invest
, vol.119
, pp. 747-754
-
-
Levitt, P.1
Campbell, D.B.2
-
54
-
-
77956187905
-
PTEN deletion enhances the regenerative ability of adult corticospinal neurons
-
doi: 10.1038/nn.2603
-
Liu, K., Lu, Y., Lee, J. K., Samara, R., Willenberg, R., Sears-Kraxberger, I., et al. (2010).PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat. Neurosci. 13,1075-1081. doi: 10.1038/nn.2603
-
(2010)
Nat. Neurosci
, vol.13
, pp. 1075-1081
-
-
Liu, K.1
Lu, Y.2
Lee, J.K.3
Samara, R.4
Willenberg, R.5
Sears-Kraxberger, I.6
-
55
-
-
0037762556
-
Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons
-
doi: 10.1016/S0896-6273(03)00228-9
-
Man, H.-Y., Wang, Q., Lu, W.-Y., Ju, W., Ahmadian, G., Liu, L., et al. (2003). Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons. Neuron 38, 611-624. doi: 10.1016/S0896-6273(03)00228-9.
-
(2003)
Neuron
, vol.38
, pp. 611-624
-
-
Man, H.-Y.1
Wang, Q.2
Lu, W.-Y.3
Ju, W.4
Ahmadian, G.5
Liu, L.6
-
56
-
-
84876144541
-
Differences in phosphodiesterase 3A and 3B expression after ischemic insult
-
doi: 10.1016/j.neures.2013.02.006
-
Mitome-Mishima, Y., Miyamoto, N., Tanaka, R., Oishi, H., Arai, H., Hattori, N., et al. (2013). Differences in phosphodiesterase 3A and 3B expression after ischemic insult. Neurosci. Res. 75, 340-348. doi: 10.1016/j.neures.2013.02.006.
-
(2013)
Neurosci. Res
, vol.75
, pp. 340-348
-
-
Mitome-Mishima, Y.1
Miyamoto, N.2
Tanaka, R.3
Oishi, H.4
Arai, H.5
Hattori, N.6
-
57
-
-
80052863881
-
Conserved interneuron-specific ErbB4 expression in frontal cortex of rodents, monkeys, and humans: Implications for schizophrenia
-
doi: 10.1016/j.biopsych.2011.04.016
-
Neddens, J., Fish, K. N., Tricoire, L., Vullhorst, D., Shamir, A., Chung, W., et al. (2011).Conserved interneuron-specific ErbB4 expression in frontal cortex of rodents, monkeys, and humans: implications for schizophrenia. Biol. Psychiatry 70, 636-645. doi: 10.1016/j.biopsych.2011.04.016
-
(2011)
Biol. Psychiatry
, vol.70
, pp. 636-645
-
-
Neddens, J.1
Fish, K.N.2
Tricoire, L.3
Vullhorst, D.4
Shamir, A.5
Chung, W.6
-
58
-
-
30344445643
-
Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia
-
doi: 10.1002/ajmg.b.30236
-
Norton, N., Moskvina, V., Morris, D. W., Bray, N. J., Zammit, S., Williams, N. M., et al. (2006). Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia. Am. J. Med. Genet. Part B Neuropsychiatr. Genet. 141B, 96-101. doi: 10.1002/ajmg.b.30236.
-
(2006)
Am. J. Med. Genet. Part B Neuropsychiatr. Genet
, vol.141 B
, pp. 96-101
-
-
Norton, N.1
Moskvina, V.2
Morris, D.W.3
Bray, N.J.4
Zammit, S.5
Williams, N.M.6
-
59
-
-
84875528574
-
Signaling by the phosphoinositide 3-kinase family in immune cells
-
doi: 10.1146/annurev-immunol-032712-095946
-
Okkenhaug, K. (2013). Signaling by the phosphoinositide 3-kinase family in immune cells. Annu. Rev. Immunol. 31, 675-704. doi: 10.1146/annurev-immunol-032712-095946.
-
(2013)
Annu. Rev. Immunol
, vol.31
, pp. 675-704
-
-
Okkenhaug, K.1
-
60
-
-
0037047590
-
Impaired B and T cell antigen receptor signaling inp110delta PI 3-kinase mutant mice
-
doi: 10.1126/science.1073560
-
Okkenhaug, K., Bilancio, A., Farjot, G., Priddle, H., Sancho, S., Peskett, E., et al. (2002). Impaired B and T cell antigen receptor signaling inp110delta PI 3-kinase mutant mice. Science 297, 1031-1034. doi: 10.1126/science.1073560.
-
(2002)
Science
, vol.297
, pp. 1031-1034
-
-
Okkenhaug, K.1
Bilancio, A.2
Farjot, G.3
Priddle, H.4
Sancho, S.5
Peskett, E.6
-
61
-
-
0037868947
-
Phosphatidylinositol 3-kinase regulates the induction of long-term potentiation through extracellular signal-related kinase-independent mechanisms
-
Opazo, P., Watabe, A. M., Grant, S. G., and O'Dell, T. J. (2003). Phosphatidylinositol 3-kinase regulates the induction of long-term potentiation through extracellular signal-related kinase-independent mechanisms. J. Neurosci. 23, 3679-3688.
-
(2003)
J. Neurosci
, vol.23
, pp. 3679-3688
-
-
Opazo, P.1
Watabe, A.M.2
Grant, S.G.3
O'Dell, T.J.4
-
62
-
-
84886100578
-
Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease
-
doi: 10.1111/jnc.12296
-
Ostapchenko, V. G., Beraldo, F. H., Guimarâes, A. L. S., Mishra, S., Guzman, M., Fan, J., et al. (2013). Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease. J. Neurochem. 127,415-425. doi: 10.1111/jnc.12296.
-
(2013)
J. Neurochem
, vol.127
, pp. 415-425
-
-
Ostapchenko, V.G.1
Beraldo, F.H.2
Guimarâes, A.L.S.3
Mishra, S.4
Guzman, M.5
Fan, J.6
-
63
-
-
37349012900
-
Role of PI3 kinase gamma in excitation-contractioncouplingandheartdisease
-
doi: 10.2174/187152907782793545
-
Oudit, G. Y., and Kassiri, Z. (2007). Role of PI3 kinase gamma in excitation-contractioncouplingandheartdisease. Cardiovasc. Hematol. Disord. DrugTargets 7, 295-304. doi: 10.2174/187152907782793545.
-
(2007)
Cardiovasc. Hematol. Disord. DrugTargets
, vol.7
, pp. 295-304
-
-
Oudit, G.Y.1
Kassiri, Z.2
-
64
-
-
55849108858
-
Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTORpathway
-
doi: 10.1126/science.1161566
-
Park, K. K., Liu, K., Hu, Y., Smith, P. D., Wang, C., Cai, B., et al. (2008). Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTORpathway. Science 322,963-966. doi: 10.1126/science.1161566.
-
(2008)
Science
, vol.322
, pp. 963-966
-
-
Park, K.K.1
Liu, K.2
Hu, Y.3
Smith, P.D.4
Wang, C.5
Cai, B.6
-
65
-
-
4344714889
-
PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects
-
doi: 10.1016/j.cell.2004.07.017
-
Patrucco, E., Notte, A., Barberis, L., Selvetella, G., Maffei, A., Brancaccio, M., et al. (2004). PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Cell 118, 375-387. doi: 10.1016/j.cell.2004.07.017.
-
(2004)
Cell
, vol.118
, pp. 375-387
-
-
Patrucco, E.1
Notte, A.2
Barberis, L.3
Selvetella, G.4
Maffei, A.5
Brancaccio, M.6
-
66
-
-
84856244294
-
The PI3K/PKB signaling module as keyregu-lator of hematopoiesis: Implications for therapeutic strategies in leukemia
-
doi: 10.1182/blood-2011-07-366203
-
Polak, R., and Buitenhuis, M. (2012). The PI3K/PKB signaling module as keyregu-lator of hematopoiesis: implications for therapeutic strategies in leukemia. Blood 119, 911-923. doi: 10.1182/blood-2011-07-366203
-
(2012)
Blood
, vol.119
, pp. 911-923
-
-
Polak, R.1
Buitenhuis, M.2
-
67
-
-
0029876116
-
Differential cellular pattern of gene expression for two distinct cGMP-inhibited cyclic nucleotide phosphodiesterases in developingandmatureratbrain
-
doi: 10.1016/0306-4522(95)00520-X
-
Reinhardt, R. R., and Bondy, C. A. (1996). Differential cellular pattern of gene expression for two distinct cGMP-inhibited cyclic nucleotide phosphodiesterases in developingandmatureratbrain. Neuroscience 72, 567-578. doi: 10.1016/0306-4522(95)00520-X
-
(1996)
Neuroscience
, vol.72
, pp. 567-578
-
-
Reinhardt, R.R.1
Bondy, C.A.2
-
68
-
-
84864363684
-
Finding a druggable target for schizophrenia
-
doi: 10.1073/pnas.1209389109
-
Rico, B. (2012). Finding a druggable target for schizophrenia. Proc. Natl. Acad. Sci. U.S.A. 109, 11902-11903. doi: 10.1073/pnas.1209389109.
-
(2012)
Proc. Natl. Acad. Sci. U.S.A
, vol.109
, pp. 11902-11903
-
-
Rico, B.1
-
69
-
-
84864400015
-
De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes
-
doi: 10.1038/ng.2331
-
Riviere, J. B., Mirzaa, G. M., O'Roak, B. J., Beddaoui, M., Alcantara, D., Conway, R. L., et al. (2012). De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes. Nat. Genet. 44, 934-940. doi: 10.1038/ng.2331.
-
(2012)
Nat. Genet
, vol.44
, pp. 934-940
-
-
Riviere, J.B.1
Mirzaa, G.M.2
O'Roak, B.J.3
Beddaoui, M.4
Alcantara, D.5
Conway, R.L.6
-
70
-
-
0033959896
-
A novel positive feedback loop mediated by the docking protein Gab1 and phos-phatidylinositol 3-kinase in epidermal growth factor receptor signaling
-
doi: 10.1128/MCB.20.4.1448-1459.2000
-
Rodrigues, G. A., Falasca, M., Zhang, Z., Ong, S. H., and Schlessinger, J. (2000). A novel positive feedback loop mediated by the docking protein Gab1 and phos-phatidylinositol 3-kinase in epidermal growth factor receptor signaling. Mol. Cell. Biol. 20, 1448-1459. doi: 10.1128/MCB.20.4.1448-1459.2000.
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 1448-1459
-
-
Rodrigues, G.A.1
Falasca, M.2
Zhang, Z.3
Ong, S.H.4
Schlessinger, J.5
-
71
-
-
0242353156
-
PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis
-
doi: 10.1038/nn1134
-
Rong, R., Ahn, J. Y., Huang, H., Nagata, E., Kalman, D., Kapp, J. A., et al. (2003). PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Nat. Neurosci. 6, 1153-1161. doi: 10.1038/nn1134.
-
(2003)
Nat. Neurosci
, vol.6
, pp. 1153-1161
-
-
Rong, R.1
Ahn, J.Y.2
Huang, H.3
Nagata, E.4
Kalman, D.5
Kapp, J.A.6
-
72
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
doi: 10.1126/science.1096502
-
Samuels, Y., Wang, Z., Bardelli, A., Silliman, N., Ptak, J., Szabo, S., et al. (2004). High frequency of mutations of the PIK3CA gene in human cancers. Science 304, 554. doi: 10.1126/science.1096502.
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
-
73
-
-
0036580702
-
Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region
-
Sanna, P. P., Cammalleri, M., Berton, F., Simpson, C., Lutjens, R., Bloom, F. E., et al. (2002). Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region. J. Neurosci. 22, 3359-3365.
-
(2002)
J. Neurosci
, vol.22
, pp. 3359-3365
-
-
Sanna, P.P.1
Cammalleri, M.2
Berton, F.3
Simpson, C.4
Lutjens, R.5
Bloom, F.E.6
-
74
-
-
0034635264
-
Function of PI3Ky in thymocyte development, T cell activation, and neutrophil migration
-
doi: 10.1126/science.287.5455.1040
-
Sasaki, T., Irie-Sasaki, J., Jones, R. G., Oliveira-Dos-Santos, A. J., Stanford, W. L., Bolon, B., et al. (2000). Function of PI3Ky in thymocyte development, T cell activation, and neutrophil migration. Science 287, 1040-1046. doi: 10.1126/science.287.5455.1040.
-
(2000)
Science
, vol.287
, pp. 1040-1046
-
-
Sasaki, T.1
Irie-Sasaki, J.2
Jones, R.G.3
Oliveira-Dos-Santos, A.J.4
Stanford, W.L.5
Bolon, B.6
-
75
-
-
1542753558
-
Association of INPP1, PIK3CG, and TSC2 gene variants with autistic disorder: Implications for phosphatidylinositol signalling in autism
-
doi: 10.1136/jmg.40.11.e119
-
Serajee, F. J., Nabi, R., Zhong, H., and Mahbubul Huq, A. H. M. (2003). Association of INPP1, PIK3CG, and TSC2 gene variants with autistic disorder: implications for phosphatidylinositol signalling in autism. J. Med. Genet. 40, e119. doi: 10.1136/jmg.40.11.e119.
-
(2003)
J. Med. Genet
, vol.e119
, pp. 40
-
-
Serajee, F.J.1
Nabi, R.2
Zhong, H.3
Mahbubul, H.A.H.M.4
-
76
-
-
74949102875
-
Dysregulation of mTORsignalingin fragileXsyndrome
-
doi: 10.1523/jneurosci.3696-09.2010
-
Sharma, A., Hoeffer, C. A., Takayasu, Y., Miyawaki, T., Mcbride, S. M., Klann, E., et al. (2010). Dysregulation of mTORsignalingin fragileXsyndrome. J. Neurosci. 30, 694-702. doi: 10.1523/jneurosci.3696-09.2010.
-
(2010)
J. Neurosci
, vol.30
, pp. 694-702
-
-
Sharma, A.1
Hoeffer, C.A.2
Takayasu, Y.3
Miyawaki, T.4
McBride, S.M.5
Klann, E.6
-
77
-
-
84866326235
-
Beta-testing of PI3-kinase inhibitors: Is betabetter?
-
doi: 10.1158/2159-8290.cd-12-0122
-
Shepherd, P. R., and Denny, W. A. (2012). Beta-testing of PI3-kinase inhibitors: is betabetter? CancerDiscov. 2,393-394. doi: 10.1158/2159-8290.cd-12-0122.
-
(2012)
CancerDiscov
, vol.2
, pp. 393-394
-
-
Shepherd, P.R.1
Denny, W.A.2
-
78
-
-
0034213075
-
The conserved phosphoinositide 3-kinase pathway determines heart size in mice
-
doi: 10.1093/emboj/19.11.2537
-
Shioi, T., Kang, P. M., Douglas, P. S., Hampe, J., Yballe, C. M., Lawitts, J., et al. (2000). The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBOJ. 19,2537-2548. doi: 10.1093/emboj/19.11.2537.
-
(2000)
EMBOJ
, vol.19
, pp. 2537-2548
-
-
Shioi, T.1
Kang, P.M.2
Douglas, P.S.3
Hampe, J.4
Yballe, C.M.5
Lawitts, J.6
-
79
-
-
32244444322
-
The involvement of ErbB4 with schizophrenia: Association and expression studies
-
doi: 10.1002/ajmg. b.30275
-
Silberberg, G., Darvasi, A., Pinkas-Kramarski, R., and Navon, R. (2006). The involvement of ErbB4 with schizophrenia: association and expression studies. Am. J. Med. Genet. Part B Neuropsychiat. Genet. 141B, 142-148. doi: 10.1002/ajmg. b.30275
-
(2006)
Am. J. Med. Genet. Part B Neuropsychiat. Genet
, vol.141 B
, pp. 142-148
-
-
Silberberg, G.1
Darvasi, A.2
Pinkas-Kramarski, R.3
Navon, R.4
-
80
-
-
77249100829
-
Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation
-
doi: 10.1016/j.cmet.2010.02.002
-
Sopasakis, V. R., Liu, P., Suzuki, R., Kondo, T., Winnay, J., Tran, T. T., et al. (2010). Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation. Cell Metab. 11, 220-230. doi: 10.1016/j.cmet.2010.02.002.
-
(2010)
Cell Metab
, vol.11
, pp. 220-230
-
-
Sopasakis, V.R.1
Liu, P.2
Suzuki, R.3
Kondo, T.4
Winnay, J.5
Tran, T.T.6
-
81
-
-
0013375948
-
Neuregulin 1 and susceptibility to schizophrenia
-
doi: 10.1086/342734
-
Stefansson, H., Petursson, H., Sigurdsson, E., Steinthorsdottir, V., Bjornsdottir, S., Sigmundsson, T., et al. (2002). Neuregulin 1 and susceptibility to schizophrenia. Am. J. Hum. Genet. 71, 877-892. doi: 10.1086/342734.
-
(2002)
Am. J. Hum. Genet
, vol.71
, pp. 877-892
-
-
Stefansson, H.1
Petursson, H.2
Sigurdsson, E.3
Steinthorsdottir, V.4
Bjornsdottir, S.5
Sigmundsson, T.6
-
82
-
-
53549099115
-
Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathwayin long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex
-
doi: 10.1101/lm.1067808
-
Sui, L., Wang, J., and Li, B. M. (2008). Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathwayin long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex. Learn. Mem. 15, 762-776. doi: 10.1101/lm.1067808.
-
(2008)
Learn. Mem
, vol.15
, pp. 762-776
-
-
Sui, L.1
Wang, J.2
Li, B.M.3
-
83
-
-
84865508373
-
Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice
-
doi: 10.1038/nature11310
-
Tsai, P. T., Hull, C., Chu, Y., Greene-Colozzi, E., Sadowski, A. R., Leech, J. M., et al. (2012). Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. Nature 488, 647-651. doi: 10.1038/nature11310.
-
(2012)
Nature
, vol.488
, pp. 647-651
-
-
Tsai, P.T.1
Hull, C.2
Chu, Y.3
Greene-Colozzi, E.4
Sadowski, A.R.5
Leech, J.M.6
-
84
-
-
84884200967
-
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer a^ oligomer bound to cellular prion protein
-
doi: 10.1016/j.neuron.2013.06.036
-
Um, J. W., Kaufman, A. C., Kostylev, M., Heiss, J. K., Stagi, M., Taka-hashi, H., et al. (2013). Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer a^ oligomer bound to cellular prion protein. Neuron 79, 887-902. doi: 10.1016/j.neuron.2013.06.036.
-
(2013)
Neuron
, vol.79
, pp. 887-902
-
-
Um, J.W.1
Kaufman, A.C.2
Kostylev, M.3
Heiss, J.K.4
Stagi, M.5
Taka-Hashi, H.6
-
85
-
-
77951621262
-
The emerging mechanisms of isoform-specific PI3K signalling
-
doi: 10.1038/nrm2882
-
Vanhaesebroeck, B., Guillermet-Guibert, J., Graupera, M., and Bilanges, B. (2010). The emerging mechanisms of isoform-specific PI3K signalling. Nat. Rev. Mol. CellBiol. 11, 329-341. doi: 10.1038/nrm2882.
-
(2010)
Nat. Rev. Mol. CellBiol
, vol.11
, pp. 329-341
-
-
Vanhaesebroeck, B.1
Guillermet-Guibert, J.2
Graupera, M.3
Bilanges, B.4
-
86
-
-
80051764374
-
Function of ERBB4 is determined by alternative splicing
-
doi: 10.4161/cc.10.16.17194
-
Veikkolainen, V., Vaparanta, K., Halkilahti, K., Iljin, K., Sundvall, M., and Elenius, K. (2011). Function of ERBB4 is determined by alternative splicing. Cell Cycle 10, 2647-2657. doi: 10.4161/cc.10.16.17194
-
(2011)
Cell Cycle
, vol.10
, pp. 2647-2657
-
-
Veikkolainen, V.1
Vaparanta, K.2
Halkilahti, K.3
Iljin, K.4
Sundvall, M.5
Elenius, K.6
-
87
-
-
70349613442
-
Selective expression of ErbB4 in interneurons, but not pyramidal cells, of the rodent hippocampus
-
doi: 10.1523/JNEUROSCI.2454-09.2009
-
Vullhorst, D., Neddens, J., Karavanova, I., Tricoire, L., Petralia, R. S., McBain, C. J., et al. (2009). Selective expression of ErbB4 in interneurons, but not pyramidal cells, of the rodent hippocampus. J. Neurosci. 29, 12255-12264. doi: 10.1523/JNEUROSCI.2454-09.2009.
-
(2009)
J. Neurosci
, vol.29
, pp. 12255-12264
-
-
Vullhorst, D.1
Neddens, J.2
Karavanova, I.3
Tricoire, L.4
Petralia, R.S.5
McBain, C.J.6
-
88
-
-
79952114000
-
The neurodevelopmental implications of PI3K signaling
-
doi: 10.1007/82_ 2010_82
-
Waite, K., and Eickholt, B. J. (2010). The neurodevelopmental implications of PI3K signaling. Curr. Top. Microbiol. Immunol. 346, 245-265. doi: 10.1007/82_ 2010_82
-
(2010)
Curr. Top. Microbiol. Immunol
, vol.346
, pp. 245-265
-
-
Waite, K.1
Eickholt, B.J.2
-
89
-
-
84875921248
-
Reversing autism by targeting downstream mTOR signaling
-
doi: 10.3389/fncel.2013.00028
-
Wang, H., and Doering, L. C. (2013). Reversing autism by targeting downstream mTOR signaling. Front. Cell. Neurosci. 7:28. doi: 10.3389/fncel.2013.00028.
-
(2013)
Front. Cell. Neurosci
, vol.7
, pp. 28
-
-
Wang, H.1
Doering, L.C.2
-
90
-
-
84865073864
-
Drugs targeting mGluR5 receptor offer "fragile" hope for autism
-
doi: 10.1038/nm0612-840
-
Williams, S. C. P. (2012). Drugs targeting mGluR5 receptor offer "fragile" hope for autism. Nat. Med. 18, 840-840. doi: 10.1038/nm0612-840.
-
(2012)
Nat. Med
, vol.18
, pp. 840
-
-
Williams, S.C.P.1
-
91
-
-
84889003871
-
Regulation of spine formation by ErbB4 in PV-positive interneurons
-
doi: 10.1523/JNEUROSCI.2090-13.2013
-
Yin, D. M., Sun, X. D., Bean, J. C., Lin, T. W., Sathyamurthy, A., Xiong, W. C., et al. (2013). Regulation of spine formation by ErbB4 in PV-positive interneurons. J. Neurosci. 33, 19295-19303. doi: 10.1523/JNEUROSCI.2090-13.2013.
-
(2013)
J. Neurosci
, vol.33
, pp. 19295-19303
-
-
Yin, D.M.1
Sun, X.D.2
Bean, J.C.3
Lin, T.W.4
Sathyamurthy, A.5
Xiong, W.C.6
-
92
-
-
29444449785
-
The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells
-
doi: 10.1073/pnas.0508988102
-
Zhao, J. J., Liu, Z., Wang, L., Shin, E., Loda, M. F., and Roberts, T. M. (2005). The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 102, 18443-18448. doi: 10.1073/pnas.0508988102.
-
(2005)
Proc. Natl. Acad. Sci. U.S.A
, vol.102
, pp. 18443-18448
-
-
Zhao, J.J.1
Liu, Z.2
Wang, L.3
Shin, E.4
Loda, M.F.5
Roberts, T.M.6
-
93
-
-
51849128358
-
Class I PI3K in oncogenic cellular transformation
-
doi: 10.1038/onc.2008.244
-
Zhao, L., and Vogt, P. K. (2008). Class I PI3K in oncogenic cellular transformation. Oncogene27, 5486-5496. doi: 10.1038/onc.2008.244.
-
(2008)
Oncogene27
, pp. 5486-5496
-
-
Zhao, L.1
Vogt, P.K.2
-
94
-
-
0035947044
-
Role of insulin and insulin receptor in learning and memory
-
doi: 10.1016/S0303-7207(01)00455-5
-
Zhao, W.-Q., and Alkon, D. L. (2001). Role of insulin and insulin receptor in learning and memory. Mol. Cell. Endocrinol. 177, 125-134. doi: 10.1016/S0303-7207(01)00455-5
-
(2001)
Mol. Cell. Endocrinol
, vol.177
, pp. 125-134
-
-
Zhao, W.-Q.1
Alkon, D.L.2
-
95
-
-
84864588849
-
The possible role of the Akt signaling pathway in schizophrenia
-
doi: 10.1016/j.brainres.2012.06.032
-
Zheng, W., Wang, H., Zeng, Z., Lin, J., Little, P. J., Srivastava, L. K., et al. (2012). The possible role of the Akt signaling pathway in schizophrenia. Brain Res. 1470, 145-158. doi: 10.1016/j.brainres.2012.06.032
-
(2012)
Brain Res
, vol.1470
, pp. 145-158
-
-
Zheng, W.1
Wang, H.2
Zeng, Z.3
Lin, J.4
Little, P.J.5
Srivastava, L.K.6
-
96
-
-
84868198811
-
PTEN signaling in autism spectrum disorders
-
doi: 10.1016/j.conb.2012.05.004
-
Zhou, J., and Parada, L. F. (2012). PTEN signaling in autism spectrum disorders. Curr. Opin. Neurobiol. 22, 873-879. doi: 10.1016/j.conb.2012.05.004
-
(2012)
Curr. Opin. Neurobiol
, vol.22
, pp. 873-879
-
-
Zhou, J.1
Parada, L.F.2
|