Chronic elevation of brain-derived neurotrophic factor by ampakines

Journal of Pharmacology and Experimental Therapeutics

Volumn 307, Issue 1, 2003, Pages 297-305

  Lauterborn, Julie C ^a   Truong, Giang S ^a   Baudry, Michel ^a,b   Bi, Xiaoning ^a   Lynch, Gary ^a   Gall, Christine M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; AMPAKINE; BRAIN DERIVED NEUROTROPHIC FACTOR; CARBACHOL; CX 546; CX 614; NEUROTROPHIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN DERIVED NEUROTROPHIC FACTOR GENE; BRAIN SLICE; CLINICAL PROTOCOL; CONTROLLED STUDY; GENE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; REFRACTORY PERIOD; WESTERN BLOTTING;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; HIPPOCAMPUS; IMMUNOLOGIC TECHNIQUES; OXAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; RNA, MESSENGER;

EID: 0141742403     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.053694     Document Type: Article

References (40)

1. Aloyz R, Fawcett JP, Kaplan DR, Murphy RA, and Miller FD (1999) Activity-dependent activation of trkB neurotrophin receptors in the adult CNS. Learn Mem 6:216-231.
2. Arai A, Kessler M, Rogers G, and Lynch G (1996) Effects of a memory enhancing drug on AMPA receptor currents and synaptic transmission in hippocampus. J Pharmacol Exp Ther 278:627-638.
3. Arai AC, Kessler M, Rogers G, and Lynch G (2000) Effects of the potent ampakine CX614 on hippocampal and recombinant AMPA receptors: interactions with cyclothiazide and GYKI 52466. Mol Pharmacol 58:802-813.
4. Balkowiec A and Katz D (2002) Cellular mechanisms regulating activity-dependent release of native brain-derived neurotrophic factor from hippocampal neurons. J Neurosci 22:10399-10407.
5. Carroll RC, Beattie EC, von Zastrow M, and Malenka RC (2001) Role of AMPA receptor endocytosis in synaptic plasticity. Nat Rev Neurosci 2:315-324.
6. Castren E, Berninger B, Leingartner A, and Lindholm D (1998) Regulation of brain derived neurotrophic factor mRNA levels in hippocampus by neuronal activity. Prog Brain Res 117:57-64.
7. Condorelli D, Belluardo N, Mudo G, Dell'Albani P, Jiang X, and Giuffrida-Stella A (1994) Changes in gene expression of AMPA-selective glutamate receptor subunits induced by status epilepticus in rat brain. Neurochem Int 25:367-376.
8. Conner JM, Lauterborn JC, and Gall CM (1998) Anterograde transport of neurotrophin proteins in the CNS - a reassessment of the neurotrophic hypothesis. Rev Neurosci 9:91-103.
9. Conner JM, Lauterborn JC, Yan Q, Gall CM, and Varon S (1997) Distribution of brain-derived neurotrophic factor (BDNF) protein and messenger RNA in the normal adult rat CNS: evidence for anterograde axonal transport. J Neurosci 17:2295-2313.
10. D'Mello S and Heinrich G (1991) Nerve growth factor gene expression: involvement of a downstream AP-1 element in basal and modulated transcription. Mol Cell Neurosci 2:157-167.
11. Dicou E, Rangon C-M, Guimiot F, Spedding M, and Gressens P (2003) Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain. Brain Res 970:221-225.
12. Elliott RC and Gall CM (2000) Changes in activating protein 1 (AP-1) composition correspond with the biphasic profile of nerve growth factor mRNA expression in rat following hilus lesion-induced seizures. J Neurosci 20:2142-2149.
13. Endres M, Fan G, Hirt L, Fujii M, Matsushita K, Liu X, Jaenisch R, and Moskowitz MA (2000) Ischemic brain damage in mice after selectively modifying BDNF or NT4 gene expression. J Cereb Blood Flow Metab 20:139-144.
14. Gall CM and Lauterborn JC (2000) Regulation of BDNF Expression: multifaceted, region-specific control ofa neuronal survival factor in the adult CNS, in Neurobiology of the Neurotrophins (Mocchetti I, ed) pp 541-579, FP Graham Publishing Co., Johnson City, TN.
15. Goff DC, Leahy L, Berman I, Posever T, Herz L, Leon AC, Johnson SA, and Lynch G (2001) A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia. J Clin Psychopharmacol 21:484-487.
16. Gold S, Hennegriff M, Lynch G, and Gall CM (1996) Relative concentrations and seizure-induced changes in mRNAs encoding three AMPA receptor subunits in hippocampus and cortex. J Comp Neurol 365:541-555.
17. Grooms S, Opitz T, Bennett M, and Zukin R (2000) Status epilepticus decreases glutamate receptor 2 mRNA and protein expression in hippocampal pyramidal cells before neuronal death. Proc Natl Acad Sci USA 97:3631-3636.
18. Heaton M, Madorsky I, Paiva M, and Mayer J (2002) Influence if ethanol on neonatal cerebellum of BDNF gene-deleted animals: analyses of effects on Purkinje cells, apoptosis-related proteins and endogenous antioxidants. J Neurobiol 51:160-176.
19. Hefti F, Knusel B, and Lapchak P (1993) Protective effects of nerve growth factor and brain-derived neurotrophic factor on basal forebrain cholinergic neurons in adult rats with partial fimbrial transections. Prog Brain Res 98:257-263.
20. Knusel B, Gao H, Okazaki T, Yoshida T, Mori N, Hefti F, and Kaplan DR (1997) Ligand-induced down-regulation of Trk messenger RNA, protein and tyrosine phosphorylation in rat cortical neurons. Neuroscience 78:851-862.
21. Lauterborn JC, Lynch G, Vanderklish P, Arai A, and Gall CM (2000) Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons. J Neurosci 20:8-21.
22. Legutko B, Li X, and Skolnick P (2001) Regulation of BDNF expression in primary neuron culture by LY392098, a novel AMPA receptor potentiator. Neuropharmacology 40:1019-1027.
23. Lever IJ, Bradbury EJ, Cunningham JR, Adelson DW, Jones MG, McMahon SB, Marvizon JC, and Malcangio M (2001) Brain-derived neurotrophic factor is released in the dorsal horn by distinctive patterns of afferent fiber stimulation. J Neurosci 21:4249-4258.
24. Lindvall O, Kokaia Z, Bengzon J, Elmér E, and Kokaia M (1994) Neurotrophins and brain insults. Trends Neurosci 17:490-496.
25. Lissin DV, Comperts SN, Carroll RC, Christine CW, Kalman D, Kitamura M, Hardy S, Nicoll R, Malenka RC, and von Zastrow M (1999) Activity differentially regulates the surface expression of synaptic AMPA and NMDA glutamate receptors. Proc Natl Acad Sci USA 95:7097-7102.
26. Lüscher C, Xia H, Beattie EC, Carroll RC, von Zastrow M, Malenka RC, and Nicoll RA (1999) Role of AMPA receptor cycling in synaptic transmission and plasticity. Neuron 24:649-658.
27. Lynch G (2002) Memory enhancement: the search for mechanism-based drugs. Nat Neurosci 5:1035-1038.
28. Lynch G, Granger R, Ambros-Ingerson J, Davis CM, Kessler M, and Schehr R (1997) Evidence that a positive modulator of AMPA-type glutamate receptors improves delayed recall in aged humans. Exp Neurol 145:89-92.
29. Mackowiak M, O'Neill MJ, Hicks CA, Bleakman D, and Skolnick P (2002) An AMPA receptor potentiator modulates hippocampal expression on BDNF: an in vivo study. Neuropharmacology 43:1-10.
30. Marini AM, Rabin SJ, Lipsky RH, and Mocchetti I (1998) Activity-dependent release of brain-derived neurotrophic factor underlies the neuroprotective effect of N-methyl-D-aspartate. J Biol Chem 273:29394-29399.
31. Morgan J, Cohen D, Hempstead J, and Curran T (1987) Mapping patterns of c-fos expression in the central nervous system after seizure. Science (Wash DC) 237:192-197.
32. 2+ signals without involvement of de novo AP-1 synthesis. Biochem Biophys Res Commun 229:788-793.
33. Siegel G and Chauhan N (2000) Neurotrophic factors in Alzheimer's and Parkinson's disease brain. Brain Res Rev 33:199-227.
34. Staubli U, Perez Y, Xu F, Rogers G, Ingvar M, Stone-Elander S, and Lynch G (1994b) Centrally active modulators of glutamate (AMPA) receptors facilitate the induction of LTP in vivo. Proc Natl Acad Sci USA 91:11158-11162.
35. Staubli U, Rogers G, and Lynch G (1994a) Facilitation of glutamate receptors enhances memory. Proc Natl Acad Sci USA 91:777-781.
36. Thoenen H and Sendtner M (2002) Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches. Nat Neurosci 5 (Suppl):1046-1050.
37. Timmusk T, Palm K, Lendahl U, and Metsis M (1999) Brain-derived neurotrophic factor expression in vivo is under the control of neuron-restrictive silencer element. J Biol Chem 274:1078-1084.
38. von Bartheld C, Wang X, and Butowt R (2001) Anterograde axonal transport, transcytosis and recycling of neurotrophic factors: the concept of trophic currencies in neural networks. Mol Neurobiol 24:1-28.
39. Wang YT and Linden DJ (2000) Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis. Neuron 25:635-647.
40. Zafra F, Hengerer B, Leibrock J, Thoenen H, and Lindholm D (1990) Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. EMBO (Eur Mol Biol Organ) J 9:3545-3550.