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Volumn 49, Issue 7, 2005, Pages 1053-1066

Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP

Author keywords

Audiogenic seizures; fmr1; Fragile X; mGluR; MPEP; Open field

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; FRAGILE X MENTAL RETARDATION PROTEIN; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST;

EID: 24344457816     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2005.06.004     Document Type: Article
Times cited : (462)

References (59)
  • 1
    • 0028149789 scopus 로고
    • Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice
    • A. Aiba, M. Kano, C. Chen, M.E. Stanton, G.D. Fox, K. Herrup, T.A. Zwingman, and S. Tonegawa Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice Cell 79 1994 377 388
    • (1994) Cell , vol.79 , pp. 377-388
    • Aiba, A.1    Kano, M.2    Chen, C.3    Stanton, M.E.4    Fox, G.D.5    Herrup, K.6    Zwingman, T.A.7    Tonegawa, S.8
  • 2
    • 1642336232 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor activation regulates Fragile X mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses
    • L.N. Antar, R. Afroz, J.B. Dictenberg, R.C. Carroll, and G.J. Bassell Metabotropic glutamate receptor activation regulates Fragile X mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses J. Neurosci. 24 2004 2648 2655
    • (2004) J. Neurosci. , vol.24 , pp. 2648-2655
    • Antar, L.N.1    Afroz, R.2    Dictenberg, J.B.3    Carroll, R.C.4    Bassell, G.J.5
  • 3
    • 0032907608 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors: Electrophysiological properties and role in plasticity
    • R. Anwyl Metabotropic glutamate receptors: electrophysiological properties and role in plasticity Brain Res. Brain Res. Rev. 29 1999 83 120
    • (1999) Brain Res. Brain Res. Rev. , vol.29 , pp. 83-120
    • Anwyl, R.1
  • 4
    • 0030887607 scopus 로고    scopus 로고
    • Microinfusion of the metabotropic glutamate receptor agonist 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid into the nucleus accumbens induces dopamine-dependent locomotor activation in the rat
    • S. Attarian, and M. Amalric Microinfusion of the metabotropic glutamate receptor agonist 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid into the nucleus accumbens induces dopamine-dependent locomotor activation in the rat Eur. J. Neurosci. 9 1997 809 816
    • (1997) Eur. J. Neurosci. , vol.9 , pp. 809-816
    • Attarian, S.1    Amalric, M.2
  • 5
    • 0028246435 scopus 로고
    • Fmr1 knockout mice: A model to study fragile X mental retardation
    • C.E. Bakker, and D-B FX Consortium Fmr1 knockout mice: a model to study fragile X mental retardation Cell 78 1994 23 33
    • (1994) Cell , vol.78 , pp. 23-33
    • Bakker, C.E.1    Consortium, D.-B.F.X.2
  • 7
    • 3042647610 scopus 로고    scopus 로고
    • The mGluR theory of fragile X mental retardation
    • M.F. Bear, K.M. Huber, and S.T. Warren The mGluR theory of fragile X mental retardation Trends Neurosci. 27 2004 370 377
    • (2004) Trends Neurosci. , vol.27 , pp. 370-377
    • Bear, M.F.1    Huber, K.M.2    Warren, S.T.3
  • 8
    • 0028287907 scopus 로고
    • A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation
    • Z.A. Bortolotto, Z.I. Bashir, C.H. Davies, and G.L. Collingridge A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation Nature 368 1994 740 743
    • (1994) Nature , vol.368 , pp. 740-743
    • Bortolotto, Z.A.1    Bashir, Z.I.2    Davies, C.H.3    Collingridge, G.L.4
  • 9
    • 0026596987 scopus 로고
    • Activation of glutamate metabotropic receptors induces long-term potentiation
    • Z.A. Bortolotto, and G.L. Collingridge Activation of glutamate metabotropic receptors induces long-term potentiation Eur. J. Pharmacol. 214 1992 297 298
    • (1992) Eur. J. Pharmacol. , vol.214 , pp. 297-298
    • Bortolotto, Z.A.1    Collingridge, G.L.2
  • 10
    • 3042685523 scopus 로고    scopus 로고
    • The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety
    • C.S. Busse, J. Brodkin, D. Tattersall, J.J. Anderson, N. Warren, L. Tehrani, L.J. Bristow, M.A. Varney, and N.D. Cosford The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4- yl)ethynyl]pyridine (MTEP) in rodent models of anxiety Neuropsychopharmacology 29 2004 1971 1979
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1971-1979
    • Busse, C.S.1    Brodkin, J.2    Tattersall, D.3    Anderson, J.J.4    Warren, N.5    Tehrani, L.6    Bristow, L.J.7    Varney, M.A.8    Cosford, N.D.9
  • 11
    • 0032882867 scopus 로고    scopus 로고
    • Induction of LTD by activation of group I mGluR in the dentate gyrus in vitro
    • N. Camodeca, N.A. Breakwell, M.J. Rowan, and R. Anwyl Induction of LTD by activation of group I mGluR in the dentate gyrus in vitro Neuropharmacology 38 1999 1597 1606
    • (1999) Neuropharmacology , vol.38 , pp. 1597-1606
    • Camodeca, N.1    Breakwell, N.A.2    Rowan, M.J.3    Anwyl, R.4
  • 12
    • 0034105111 scopus 로고    scopus 로고
    • Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893)
    • A.G. Chapman, K. Nanan, M. Williams, and B.S. Meldrum Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893) Neuropharmacology 39 2000 1567 1574
    • (2000) Neuropharmacology , vol.39 , pp. 1567-1574
    • Chapman, A.G.1    Nanan, K.2    Williams, M.3    Meldrum, B.S.4
  • 13
    • 0035804765 scopus 로고    scopus 로고
    • Fragile X mice develop sensory hyperreactivity to auditory stimuli
    • L. Chen, and M. Toth Fragile X mice develop sensory hyperreactivity to auditory stimuli Neuroscience 103 2001 1043 1050
    • (2001) Neuroscience , vol.103 , pp. 1043-1050
    • Chen, L.1    Toth, M.2
  • 19
    • 0034942216 scopus 로고    scopus 로고
    • Chemical induction of mGluR5- and protein synthesis-dependent long-term depression in hippocampal area CA1
    • K.M. Huber, J.C. Roder, and M.F. Bear Chemical induction of mGluR5- and protein synthesis-dependent long-term depression in hippocampal area CA1 J. Neurophysiol. 86 2001 321 325
    • (2001) J. Neurophysiol. , vol.86 , pp. 321-325
    • Huber, K.M.1    Roder, J.C.2    Bear, M.F.3
  • 24
  • 25
    • 0035368955 scopus 로고    scopus 로고
    • The fragile X mental retardation protein inhibits translation via interacting with mRNA
    • Z. Li, Y. Zhang, L. Ku, K.D. Wilkinson, S.T. Warren, and Y. Feng The fragile X mental retardation protein inhibits translation via interacting with mRNA Nucleic Acids Res. 29 2001 2276 2283
    • (2001) Nucleic Acids Res. , vol.29 , pp. 2276-2283
    • Li, Z.1    Zhang, Y.2    Ku, L.3    Wilkinson, K.D.4    Warren, S.T.5    Feng, Y.6
  • 26
    • 0028208421 scopus 로고
    • Long-term synaptic depression in the mammalian brain
    • D.J. Linden Long-term synaptic depression in the mammalian brain Neuron 12 1994 457 472
    • (1994) Neuron , vol.12 , pp. 457-472
    • Linden, D.J.1
  • 27
    • 3142737454 scopus 로고    scopus 로고
    • Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, d-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice
    • A.J. McGeehan, P.H. Janak, and M.F. Olive Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, d-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice Psychopharmacology (Berl) 174 2004 266 273
    • (2004) Psychopharmacology (Berl) , vol.174 , pp. 266-273
    • McGeehan, A.J.1    Janak, P.H.2    Olive, M.F.3
  • 28
    • 0025937352 scopus 로고
    • The effects of trans-ACPD on long-term potentiation in the rat hippocampal slice
    • N. McGuinness, R. Anwyl, and M. Rowan The effects of trans-ACPD on long-term potentiation in the rat hippocampal slice Neuroreport 2 1991 688 690
    • (1991) Neuroreport , vol.2 , pp. 688-690
    • McGuinness, N.1    Anwyl, R.2    Rowan, M.3
  • 29
    • 0032561736 scopus 로고    scopus 로고
    • Depletion of dopamine in the nucleus accumbens prevents the generation of locomotion by metabotropic glutamate receptor activation
    • D. Meeker, J.H. Kim, and P. Vezina Depletion of dopamine in the nucleus accumbens prevents the generation of locomotion by metabotropic glutamate receptor activation Brain Res. 812 1998 260 264
    • (1998) Brain Res. , vol.812 , pp. 260-264
    • Meeker, D.1    Kim, J.H.2    Vezina, P.3
  • 30
    • 0024603931 scopus 로고
    • An in vivo electrophysiological study of the ontogeny of excitatory and inhibitory processes in the rat hippocampus
    • H.B. Michelson, and E.W. Lothman An in vivo electrophysiological study of the ontogeny of excitatory and inhibitory processes in the rat hippocampus Brain Res. Dev. Brain Res. 47 1989 113 122
    • (1989) Brain Res. Dev. Brain Res. , vol.47 , pp. 113-122
    • Michelson, H.B.1    Lothman, E.W.2
  • 33
    • 0036113758 scopus 로고    scopus 로고
    • Behavioral effects of the selective blockade of metabotropic glutamate receptor subtype 5 in experimental hypoxia
    • A. Nadlewska, H. Car, R.J. Wisniewska, and K. Wisniewski Behavioral effects of the selective blockade of metabotropic glutamate receptor subtype 5 in experimental hypoxia Pol. J. Pharmacol. 54 2002 95 102
    • (2002) Pol. J. Pharmacol. , vol.54 , pp. 95-102
    • Nadlewska, A.1    Car, H.2    Wisniewska, R.J.3    Wisniewski, K.4
  • 34
    • 0035879180 scopus 로고    scopus 로고
    • Abnormal development of dendritic spines in FMR1 knock-out mice
    • E.A. Nimchinsky, A.M. Oberlander, and K. Svoboda Abnormal development of dendritic spines in FMR1 knock-out mice J. Neurosci. 21 2001 5139 5146
    • (2001) J. Neurosci. , vol.21 , pp. 5139-5146
    • Nimchinsky, E.A.1    Oberlander, A.M.2    Svoboda, K.3
  • 35
    • 0030995998 scopus 로고    scopus 로고
    • Two distinct forms of long-term depression coexist in CA1 hippocampal pyramidal cells
    • S.H. Oliet, R.C. Malenka, and R.A. Nicoll Two distinct forms of long-term depression coexist in CA1 hippocampal pyramidal cells Neuron 18 1997 969 982
    • (1997) Neuron , vol.18 , pp. 969-982
    • Oliet, S.H.1    Malenka, R.C.2    Nicoll, R.A.3
  • 36
    • 0034868541 scopus 로고    scopus 로고
    • Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats
    • K. Ossowska, J. Konieczny, S. Wolfarth, J. Wieronska, and A. Pilc Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats Neuropharmacology 41 2001 413 420
    • (2001) Neuropharmacology , vol.41 , pp. 413-420
    • Ossowska, K.1    Konieczny, J.2    Wolfarth, S.3    Wieronska, J.4    Pilc, A.5
  • 38
    • 0022620470 scopus 로고
    • Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat
    • S. Pellow, and S.E. File Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat Pharmacol. Biochem. Behav. 24 1986 525 529
    • (1986) Pharmacol. Biochem. Behav. , vol.24 , pp. 525-529
    • Pellow, S.1    File, S.E.2
  • 41
    • 0037470154 scopus 로고    scopus 로고
    • The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: A review
    • L. Prut, and C. Belzung The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review Eur. J. Pharmacol. 463 2003 3 33
    • (2003) Eur. J. Pharmacol. , vol.463 , pp. 3-33
    • Prut, L.1    Belzung, C.2
  • 42
    • 0031044630 scopus 로고    scopus 로고
    • A multiple-test study of anxiety-related behaviours in six inbred rat strains
    • A. Ramos, O. Berton, P. Mormede, and F. Chaouloff A multiple-test study of anxiety-related behaviours in six inbred rat strains Behav. Brain Res. 85 1997 57 69
    • (1997) Behav. Brain Res. , vol.85 , pp. 57-69
    • Ramos, A.1    Berton, O.2    Mormede, P.3    Chaouloff, F.4
  • 43
    • 9644281626 scopus 로고    scopus 로고
    • Role of neurosteroids in catamenial epilepsy
    • D.S. Reddy Role of neurosteroids in catamenial epilepsy Epilepsy Res. 62 2004 99 118
    • (2004) Epilepsy Res. , vol.62 , pp. 99-118
    • Reddy, D.S.1
  • 45
    • 0015904883 scopus 로고
    • Relationships between exploratory behaviour and fear: A review
    • P.A. Russell Relationships between exploratory behaviour and fear: a review Br. J. Psychol. 64 1973 417 433
    • (1973) Br. J. Psychol. , vol.64 , pp. 417-433
    • Russell, P.A.1
  • 46
    • 0028298584 scopus 로고
    • The stimulant effect of modafinil on wakefulness is not associated with an increase in anxiety in mice. a comparison with dexamphetamine
    • P. Simon, C. Panissaud, and J. Costentin The stimulant effect of modafinil on wakefulness is not associated with an increase in anxiety in mice. A comparison with dexamphetamine Psychopharmacology (Berl) 114 1994 597 600
    • (1994) Psychopharmacology (Berl) , vol.114 , pp. 597-600
    • Simon, P.1    Panissaud, C.2    Costentin, J.3
  • 47
    • 0034693328 scopus 로고    scopus 로고
    • Effects of the prototypical mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats
    • W.P. Spooren, F. Gasparini, R. Bergmann, and R. Kuhn Effects of the prototypical mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats Eur. J. Pharmacol. 406 2000 403 410
    • (2000) Eur. J. Pharmacol. , vol.406 , pp. 403-410
    • Spooren, W.P.1    Gasparini, F.2    Bergmann, R.3    Kuhn, R.4
  • 48
    • 0033680311 scopus 로고    scopus 로고
    • Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents
    • W.P. Spooren, A. Vassout, H.C. Neijt, R. Kuhn, F. Gasparini, S. Roux, R.D. Porsolt, and C. Gentsch Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents J. Pharmacol. Exp. Ther. 295 2000 1267 1275
    • (2000) J. Pharmacol. Exp. Ther. , vol.295 , pp. 1267-1275
    • Spooren, W.P.1    Vassout, A.2    Neijt, H.C.3    Kuhn, R.4    Gasparini, F.5    Roux, S.6    Porsolt, R.D.7    Gentsch, C.8
  • 49
    • 0345492360 scopus 로고    scopus 로고
    • The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95
    • P.K. Todd, K.J. Mack, and J.S. Malter The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95 Proc. Natl Acad. Sci. U.S.A. 100 2003 14374 14378
    • (2003) Proc. Natl Acad. Sci. U.S.A. , vol.100 , pp. 14374-14378
    • Todd, P.K.1    MacK, K.J.2    Malter, J.S.3
  • 50
    • 0037456073 scopus 로고    scopus 로고
    • Whisker stimulation-dependent translation of FMRP in the barrel cortex requires activation of type I metabotropic glutamate receptors
    • P.K. Todd, J.S. Malter, and K.J. Mack Whisker stimulation-dependent translation of FMRP in the barrel cortex requires activation of type I metabotropic glutamate receptors Brain Res. Mol. Brain Res. 110 2003 267 278
    • (2003) Brain Res. Mol. Brain Res. , vol.110 , pp. 267-278
    • Todd, P.K.1    Malter, J.S.2    MacK, K.J.3
  • 51
    • 0037022346 scopus 로고    scopus 로고
    • Dendritic spines elongate after stimulation of group 1 metabotropic glutamate receptors in cultured hippocampal neurons
    • P.W. Vanderklish, and G.M. Edelman Dendritic spines elongate after stimulation of group 1 metabotropic glutamate receptors in cultured hippocampal neurons Proc. Natl Acad. Sci. U.S.A. 99 2002 1639 1644
    • (2002) Proc. Natl Acad. Sci. U.S.A. , vol.99 , pp. 1639-1644
    • Vanderklish, P.W.1    Edelman, G.M.2
  • 53
    • 0000650706 scopus 로고
    • The open-field test: A critical review
    • R.N. Walsh, and R.A. Cummins The open-field test: a critical review Psychol. Bull. 83 1976 482 504
    • (1976) Psychol. Bull. , vol.83 , pp. 482-504
    • Walsh, R.N.1    Cummins, R.A.2
  • 58
    • 0037423293 scopus 로고    scopus 로고
    • The Fragile X Syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses
    • F. Zalfa, M. Giorgi, B. Primerano, A. Moro, A. Di Penta, S. Reis, B. Oostra, and C. Bagni The Fragile X Syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses Cell 112 2003 317 327
    • (2003) Cell , vol.112 , pp. 317-327
    • Zalfa, F.1    Giorgi, M.2    Primerano, B.3    Moro, A.4    Di Penta, A.5    Reis, S.6    Oostra, B.7    Bagni, C.8
  • 59
    • 0026735789 scopus 로고
    • Metabotropic glutamate receptors are required for the induction of long-term potentiation
    • F. Zheng, and J.P. Gallagher Metabotropic glutamate receptors are required for the induction of long-term potentiation Neuron 9 1992 163 172
    • (1992) Neuron , vol.9 , pp. 163-172
    • Zheng, F.1    Gallagher, J.P.2


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