Quantitative localization of heterogeneous methyl-CpG-binding protein 2 (MeCP2) expression phenotypes in normal and Rett syndrome brain by laser scanning cytometry

Human Molecular Genetics

Volumn 10, Issue 17, 2001, Pages 1729-1740

  LaSalle, Janine M ^a   Goldstine, Jared ^a   Balmer, Damina ^a   Greco, Claudia M ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; EPITOPE; METHYL CPG BINDING PROTEIN 2; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN NERVE CELL; CARBOXY TERMINAL SEQUENCE; CELL COUNT; CELL SUBPOPULATION; CELL TYPE; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CONTROLLED STUDY; CYTOMETRY; DEVELOPMENTAL DISORDER; FEMALE; GENE MUTATION; GENETIC CODE; GENETIC HETEROGENEITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; LASER; MOSAICISM; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ASSAY; RANDOMIZATION; RETT SYNDROME;

ANIMALIA;

EID: 0035880454     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/10.17.1729     Document Type: Article

References (29)

1. Review of Rett syndrome
2. Rett syndrome: Clinical update and review of recent genetic advances
3. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
4. Influence of mutation type and X chromosome inactivation on Rett syndrome phenotypes
5. Long-read sequence analysis of the MECP2 gene in Rett syndrome patients: Correlation of disease severity with mutation type and location
6. Rett syndrome: Analysis of MECP2 and clinical characterization of 31 patients
7. Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA
8. Isolation, physical mapping, and northern analysis of the X-linked human gene encoding methyl CpG-binding protein, MECP2
9. Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA
10. DNA methylation specifies chromosomal localization of MeCP2
11. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin
12. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
13. A complex pattern of evolutionary conservation and alternative polyadenylation within the long 3′-untranslated region of the methyl-CpG-binding protein 2 gene (MeCP2) suggests a regulatory role in gene expression
14. Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions
15. Rett syndrome: A surprising result of mutation in MECP2
16. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
17. Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
18. Laser-scanning cytometry: A new instrumentation with many applications
19. Slide-based laser scanning cytometry
20. Cell cycle effects and induction of apoptosis caused by infection of HL-60 cells with human granulocytic ehrlichiosis pathogen measured by flow and laser scanning cytometry
21. Laser scanning cytometry for comet assay analysis
22. Intracellular localization of cyclin B1 during the cell cycle in glioma cells
23. DNA ploidy analysis by laser scanning cytometry (LSC) in colorectal cancers and comparison with flow cytometry
24. Tissue microarrays for high-throughput molecular profiling of tumor specimens
25. Patterns of X chromosome inactivation in the Rett syndrome
26. MECP2 truncating mutations cause histone H4 hyperacetylation in Rett syndrome
27. Tissue microarray technology for high-throughput molecular profiling of cancer
28. Automated quantitation of cell-mediated HIV-1 infection of human syncytiotrophoblast cells using fluorescence in situ hybridization and laser scanning cytometry
29. MECP2 mutations account for most cases of typical forms of Rett syndrome