Brief report: Acamprosate in fragile X syndrome

Journal of Autism and Developmental Disorders

Volumn 40, Issue 11, 2010, Pages 1412-1416

  Erickson, Craig A ^a,b   Mullett, Jennifer E ^a,b   McDougle, Christopher J ^a,b  

^a INDIANA UNIVERSITY   (United States)

^b RILEY HOSPITAL FOR CHILDREN   (United States)

Author keywords

Acamprosate; Fragile X syndrome; Irritability; Language; MGluR5

Indexed keywords

ACAMPROSATE; ARIPIPRAZOLE; DEXAMPHETAMINE; PROPRANOLOL; ZIPRASIDONE;

ADULT; ARTICLE; AUTISM; CASE REPORT; FRAGILE X SYNDROME; HUMAN; INTERPERSONAL COMMUNICATION; MALE; MEDICAL RECORD; MORNING DOSAGE; PRIORITY JOURNAL; SEDATION; SIDE EFFECT; TREATMENT OUTCOME; VOMITING;

ADOLESCENT; AUTISTIC DISORDER; COMMUNICATION; COMORBIDITY; FRAGILE X SYNDROME; HUMANS; MALE; RECEPTORS, METABOTROPIC GLUTAMATE; TAURINE; TREATMENT OUTCOME; VERBAL BEHAVIOR; YOUNG ADULT;

EID: 78549286298     PISSN: 01623257     EISSN: 15733432     Source Type: Journal    
DOI: 10.1007/s10803-010-0988-9     Document Type: Article

References (30)

1. M al Qatari S Khan B Harris J Littleton 2001 Acamprosate is neuroprotective against glutamate-induced excitotoxicity when enhanced by ethanol withdrawal in neocortical cultures of fetal rat brain Alcoholism, Clinical and Experimental Research 25 9 1276 1283 10.1111/j.1530-0277.2001. tb02348.x 11584146
2. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders, Four Edition, Text Revision (4th ed.). Washington, DC: American Psychiatric Association.
3. MF Bear KM Huber ST Warren 2004 The mGluR theory of fragile X mental retardation Trends in Neurosciences 27 7 370 377 10.1016/j.tins.2004.04.009 15219735 (Pubitemid 38829251)
4. E Berry-Kravis D Hessl S Coffey C Hervey A Schneider J Yuhas, et al. 2009 A pilot open label, single dose trial of fenobam in adults with fragile X syndrome Journal of Medical Genetics 46 4 266 271 10.1136/jmg.2008.063701 19126569
5. E Berry-Kravis A Sumis C Hervey M Nelson SW Porges N Weng, et al. 2008 Open-label treatment trial of lithium to target the underlying defect in fragile X syndrome Journal of Developmental and Behavioral Pediatrics 29 4 293 302 10.1097/DBP.0b013e31817dc447 18698192
6. YA Blednov R Adron Harris 2008 Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: Relationship to acamprosate actions International Journal of Neuropsychopharmacology 11 6 775 793 18377703
7. SC Chuang W Zhao R Bauchwitz Q Yan R Bianchi RK Wong 2005 Prolonged epileptiform discharges induced by altered group I metabotropic glutamate receptor-mediated synaptic responses in hippocampal slices of a fragile X mouse model Journal of Neuroscience 25 35 8048 8055 10.1523/JNEUROSCI.1777-05.2005 16135762 (Pubitemid 41254408)
8. Y de Diego-Otero Y Romero-Zerbo R el Bekay J Decara L Sanchez F Rodriguez-de Fonseca, et al. 2009 Alpha-tocopherol protects against oxidative stress in the fragile X knockout mouse: An experimental therapeutic approach for the Fmr1 deficiency Neuropsychopharmacology 34 4 1011 1026 10.1038/npp.2008.152 18843266
9. FM de Vrij J Levenga HC van der Linde SK Koekkoek CI De Zeeuw DL Nelson, et al. 2008 Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice Neurobiology of Diseases 31 1 127 132 10.1016/j.nbd.2008.04.002 (Pubitemid 351822560)
10. P De Witte J Littleton P Parot G Koob 2005 Neuroprotective and abstinence-promoting effects of acamprosate: Elucidating the mechanism of action CNS Drugs 19 6 517 537 10.2165/00023210-200519060-00004 15963001 (Pubitemid 41058377)
11. D Devys Y Lutz N Rouyer JP Bellocq JL Mandel 1993 The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation Nature Genetics 4 4 335 340 10.1038/ng0893-335 8401578 (Pubitemid 23231479)
12. G Dolen MF Bear 2008 Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome Journal of Physiology 586 6 1503 1508 10.1113/jphysiol.2008.150722 18202092 (Pubitemid 351404955)
13. G Dolen E Osterweil BS Rao GB Smith BD Auerbach S Chattarji, et al. 2007 Correction of fragile X syndrome in mice Neuron 56 6 955 962 10.1016/j.neuron.2007.12.001 18093519 (Pubitemid 350251119)
14. R el Bekay Y Romero-Zerbo J Decara L Sanchez-Salido I Del Arco-Herrera F Rodriguez-de Fonseca, et al. 2007 Enhanced markers of oxidative stress, altered antioxidants and NADPH-oxidase activation in brains from Fragile X mental retardation 1-deficient mice, a pathological model for Fragile X syndrome European Journal of Neuroscience 26 11 3169 3180 10.1111/j.1460-9568.2007.05939. x 18005058 (Pubitemid 350135184)
15. Erickson, C. A., Mullett, J. E., & McDougle, C. J. (2009). Open-label memantine in Fragile X Syndrome. J Autism Dev Disord.
16. Forest Pharmaceuticals Inc. (2005). Campral Product Information Retrieved August 17, 2009, from http://www.frx.com/pi/campral-pi.pdf.
17. WT Greenough AY Klintsova SA Irwin R Galvez KE Bates IJ Weiler 2001 Synaptic regulation of protein synthesis and the fragile X protein Proc Natl Acad Sci USA 98 13 7101 7106 10.1073/pnas.141145998 11416194 (Pubitemid 32567909)
18. T Gupta YM Syed AA Revis SA Miller M Martinez KA Cohn, et al. 2008 Acute effects of acamprosate and MPEP on ethanol Drinking-in-the-Dark in male C57BL/6J mice Alcoholism, Clinical and Experimental Research 32 11 1992 1998 18782337
19. Guy, W. (1976). ECDEU assessment manual for psychopharmacology, Publication No. 76-338. Washington, DC: US DHEW, NIMH.
20. PJ Hagerman 2008 The fragile X prevalence paradox Journal of Medical Genetics 45 8 498 499 10.1136/jmg.2008.059055 18413371
21. BR Harris MA Prendergast DA Gibson DT Rogers JA Blanchard RC Holley, et al. 2002 Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a novel site of action at metabotropic glutamate receptors Alcoholism, Clinical and Experimental Research 26 12 1779 1793 12500101
22. G Jaeschke JG Wettstein RE Nordquist W Spooren 2008 mGlu5 receptor antagonists and their potential therapeutic potential Expert Opinion on Therapeutic Patents 18 2 123 142 10.1517/13543776.18.2.123 (Pubitemid 351377052)
23. C Lord M Rutter A Le Couteur 1994 Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders Journal of Autism and Developmental Disorders 24 5 659 685 10.1007/BF02172145 7814313 (Pubitemid 24309810)
24. K Mann F Kiefer R Spanagel J Littleton 2008 Acamprosate: Recent findings and future research directions Alcoholism, Clinical and Experimental Research 32 7 1105 1110 10.1111/j.1530-0277.2008.00690.x 18540918
25. SM McBride CH Choi Y Wang D Liebelt E Braunstein D Ferreiro, et al. 2005 Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome Neuron 45 5 753 764 10.1016/j.neuron.2005.01.038 15748850 (Pubitemid 40320709)
26. M Pieretti FP Zhang YH Fu ST Warren BA Oostra CT Caskey, et al. 1991 Absence of expression of the FMR-1 gene in fragile X syndrome Cell 66 4 817 822 10.1016/0092-8674(91)90125-I 1878973
27. MT Reilly IA Lobo LM McCracken CM Borghese D Gong T Horishita, et al. 2008 Effects of acamprosate on neuronal receptors and ion channels expressed in Xenopus oocytes Alcoholism, Clinical and Experimental Research 32 2 188 196 10.1111/j.1530-0277.2007.00569.x 18226119
28. Y Romero-Zerbo J Decara R el Bekay L Sanchez-Salido I Del Arco-Herrera FR de Fonseca, et al. 2009 Protective effects of melatonin against oxidative stress in Fmr1 knockout mice: A therapeutic research model for the fragile X syndrome Journal of Pineal Research 46 2 224 234 10.1111/j.1600-079X.2008.00653. x 19141086
29. Ronesi, J. A., & Huber, K. M. (2008). Metabotropic glutamate receptors and fragile x mental retardation protein: Partners in translational regulation at the synapse. Sci Signal, 1(5), pe6.
30. QJ Yan M Rammal M Tranfaglia RP Bauchwitz 2005 Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP Neuropharmacology 49 7 1053 1066 10.1016/j.neuropharm.2005.06.004 16054174 (Pubitemid 41503304)