Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant

Psychopharmacology

Volumn 231, Issue 6, 2014, Pages 1227-1235

  Pop, Andreea S ^a   Levenga, Josien ^b   De Esch, Celine E F ^a   Buijsen, Ronald A M ^a   Nieuwenhuizen, Ingeborg M ^a   Li, Tracy ^a   Isaacs, Aaron ^a   Gasparini, Fabrizio ^c   Oostra, Ben A ^a   Willemsen, Rob ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

AFQ056 Mavoglurant; Dendritic spines; FMR1; FMRP; Fragile X syndrome; Hippocampal CA1

Indexed keywords

FRAGILE X MENTAL RETARDATION PROTEIN; MAVOGLURANT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENDRITIC SPINE; FMR1 GENE; FRAGILE X SYNDROME; HIPPOCAMPAL CA1 REGION; KNOCKOUT MOUSE; LONG TERM CARE; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SPINE; WILD TYPE; YOUNG ADULT;

ANIMALS; CA1 REGION, HIPPOCAMPAL; DENDRITIC SPINES; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID ANTAGONISTS; FRAGILE X MENTAL RETARDATION PROTEIN; FRAGILE X SYNDROME; INDOLES; MALE; MICE; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; PHENOTYPE; PYRAMIDAL CELLS; RECEPTOR, METABOTROPIC GLUTAMATE 5;

EID: 84896713573     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-012-2947-y     Document Type: Article

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