Temporal and regional alterations in NMDA receptor expression in Mecp2-null mice

Anatomical Record

Volumn 294, Issue 10, 2011, Pages 1624-1634

  Blue, Mary E ^a,b   Kaufmann, Walter E ^a,b   Bressler, Joseph ^a,c   Eyring, Charlotte ^a   O'driscoll, Cliona ^a   Naidu, Sakkubai ^a,b   Johnston, Michael V ^a,b  

^a Kennedy Krieger Inc   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Johns Hopkins University   (United States)

Author keywords

Autoradiography; Development; Mouse models; NMDA; Rett syndrome; Western blots

Indexed keywords

METHYL CPG BINDING PROTEIN 2; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BRAIN REGION; FRONTAL CORTEX; GENE MUTATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROSPLENIAL CORTEX; SOMATOSENSORY CORTEX; THALAMUS; VISUAL CORTEX; WILD TYPE;

ANIMALS; AUTORADIOGRAPHY; BLOTTING, WESTERN; BRAIN; FEMALE; MALE; METHYL-CPG-BINDING PROTEIN 2; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, N-METHYL-D-ASPARTATE;

AVES; MUS;

EID: 80053015805     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.21380     Document Type: Article

References (58)

1. Aber KM, Nori P, MacDonald SM, Bibat G, Jarrar MH, Kaufmann WE. 2003. Methyl-CpG-binding protein 2 is localized in the postsynaptic compartment: an immunochemical study of subcellular fractions. Neuroscience 116: 77-80.
2. Ackermann H, Riecker A. 2010. The contribution(s) of the insula to speech production: a review of the clinical and functional imaging literature. Brain Struct Funct 214: 419-433.
3. Amir RE, Van den Veyver IB, Wan M, Tran CQ, Francke U, Zoghbi HY. 1999. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet 23: 185-188.
4. Ampuero E, Dagnino-Subiabre A, Sandoval R, Zepeda-Carreno R, Sandoval S, Viedma A, Aboitiz F, Orrego F, Wyneken U. 2007. Status epilepticus induces region-specific changes in dendritic spines, dendritic length and TrkB protein content of rat brain cortex. Brain Res 1150: 225-238.
5. Asaka Y, Jugloff DG, Zhang L, Eubanks JH, Fitzsimonds RM. 2006. Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome. Neurobiol Dis 21: 217-227.
6. Blue ME, Martin LJ, Brennan EM, Johnston MV. 1997. Ontogeny of non-NMDA glutamate receptors in rat barrel field cortex: I. Metabotropic receptors. J Comp Neurol 386: 16-28.
7. Blue ME, Naidu S, Johnston MV. 1999a. Altered development of glutamate and GABA receptors in the basal ganglia of girls with Rett syndrome. ExpNeurol 156: 345-352.
8. Blue ME, Naidu S, Johnston MV. 1999b. Development of amino acid receptors in frontal cortex from girls with Rett syndrome. Ann Neurol 45: 541-545.
9. Braunschweig D, Simcox T, Samaco RC, LaSalle JM. 2004. X-Chromosome inactivation ratios affect wild-type MeCP2 expression within mosaic Rett syndrome and Mecp2-/+ mouse brain. Hum Mol Genet 13: 1275-1286.
10. Brennan EM, Martin LJ, Johnston MV, Blue ME. 1997. Ontogeny of non-NMDA glutamate receptors in rat barrel field cortex: II. AMPA and kainate receptors. J Comp Neurol 386: 29-45.
11. Cardoso A, Madeira MD, Paula-Barbosa MM, Lukoyanov NV. 2008. Retrosplenial granular b cortex in normal and epileptic rats: a stereological study. Brain Res 1218: 206-214.
12. Chen RZ, Akbarian S, Tudor M, Jaenisch R. 2001. Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat Genet 27: 327-331.
13. Cohen DR, Matarazzo V, Palmer AM, Tu Y, Jeon OH, Pevsner J, Ronnett GV. 2003. Expression of MeCP2 in olfactory receptor neurons is developmentally regulated and occurs before synaptogenesis. Mol Cell Neurosci 22: 417-429.
14. Colantuoni C, Jeon OH, Hyder K, Chenchik A, Khimani AH, Narayanan V, Hoffman EP, Kaufmann WE, Naidu S, Pevsner J. 2001. Gene expression profiling in postmortem Rett Syndrome brain: differential gene expression and patient classification. Neurobiol Dis 8: 847-865.
15. D'Cruz JA, Wu C, Zahid T, El-Hayek Y, Zhang L, Eubanks JH. 2010. Alterations of cortical and hippocampal EEG activity in MeCP2-deficient mice. Neurobiol Dis 38: 8-16.
16. Dani VS, Chang Q, Maffei A, Turrigiano GG, Jaenisch R, Nelson SB. 2005. Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome. Proc Natl Acad Sci USA 102: 12560-12565.
17. Dani VS, Nelson SB. 2009. Intact long-term potentiation but reduced connectivity between neocortical layer 5 pyramidal neurons in a mouse model of Rett syndrome. J Neurosci 29: 11263-11270.
18. Degano AL, Pasterkamp RJ, Ronnett GV. 2009. MeCP2 deficiency disrupts axonal guidance, fasciculation, and targeting by altering Semaphorin 3F function. Mol Cell Neurosci 42: 243-254.
19. Fischer M, Reuter J, Gerich FJ, Hildebrandt B, Hagele S, Katschinski D, Muller M. 2009. Enhanced hypoxia susceptibility in hippocampal slices from a mouse model of rett syndrome. J Neurophysiol 101: 1016-1032.
20. Guy J, Hendrich B, Holmes M, Martin JE, Bird A. 2001. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat Genet 27: 322-326.
21. Hagberg B, Goutieres F, Hanefeld F, Rett A, Wilson J. 1985. Rett syndrome: criteria for inclusion and exclusion. Brain Dev 7: 372-373.
22. Hagerman RJ, Berry-Kravis E, Kaufmann WE, Ono MY, Tartaglia N, Lachiewicz A, Kronk R, Delahunty C, Hessl D, Visootsak J, Picker J, Gane L, Tranfaglia M. 2009. Advances in the treatment of fragile X syndrome. Pediatrics 123: 378-390.
23. Hamberger A, Gillberg C, Palm A, Hagberg B. 1992. Elevated CSF glutamate in Rett syndrome. Neuropediatrics 23: 212-213.
24. Hoffbuhr K, Devaney JM, LaFleur B, Sirianni N, Scacheri C, Giron J, Schuette J, Innis J, Marino M, Philippart M, Narayanan V, Umansky R, Kronn D, Hoffman EP, Naidu S. 2001. MeCP2 mutations in children with and without the phenotype of Rett syndrome. Neurology 56: 1486-1495.
25. Horska A, Farage L, Bibat G, Nagae LM, Kaufmann WE, Barker PB, Naidu S. 2009. Brain metabolism in Rett syndrome: age, clinical, and genotype correlations. Ann Neurol 65: 90-97.
26. Jaarsma D, Sebens JB, Korf J. 1993. Glutamate dehydrogenase improves binding of [3H]CGP39653 to NMDA receptors in the autoradiographic assay. J Neurosci Methods 46: 133-138.
27. Jentarra GM, Olfers SL, Rice SG, Srivastava N, Homanics GE, Blue M, Naidu S, Narayanan V. 2010. Abnormalities of cell packing density and dendritic complexity in the MeCP2 A140V mouse model of Rett syndrome/X-linked mental retardation. BMC Neurosci 11: 19:1-15.
28. Johnston MV, Blue ME, Naidu S. 2005. Rett syndrome and neuronal development. J Child Neurol 20: 759-763.
29. Johnston MV, Jeon OH, Pevsner J, Blue ME, Naidu S. 2001. Neurobiology of Rett syndrome: a genetic disorder of synapse development. Brain Dev 23(Suppl 1): S206-S213.
30. Johnston MV, Mullaney B, Blue ME. 2003. Neurobiology of Rett syndrome. J Child Neurol 18: 688-692.
31. Kaufmann WE, Johnston MV, Blue ME. 2005. MeCP2 expression and function during brain development: implications for Rett syndrome's pathogenesis and clinical evolution. Brain Dev 27(Suppl 1): S77-S87.
32. Kukko-Lukjanov TK, Lintunen M, Jalava N, Lauren HB, Lopez-Picon FR, Michelsen KA, Panula P, Holopainen IE. 2010. Involvement of histamine 1 receptor in seizure susceptibility and neuroprotection in immature mice. Epilepsy Res 90: 8-15.
33. Lappalainen R, Riikonen RS. 1996. High levels of cerebrospinal fluid glutamate in Rett syndrome. Pediatr Neurol 15: 213-216.
34. LaSalle JM. 2004. Paradoxical role of methyl-CpG-binding protein 2 in Rett syndrome. Curr Top Dev Biol 59: 61-86.
35. Lawson-Yuen A, Liu D, Han L, Jiang ZI, Tsai GE, Basu AC, Picker J, Feng J, Coyle JT. 2007. Ube3a mRNA and protein expression are not decreased in Mecp2R168X mutant mice. Brain Res 1180: 1-6.
36. Maliszewska-Cyna E, Bawa D, Eubanks JH. 2010. Diminished prevalence but preserved synaptic distribution of N-methyl-d-aspartate receptor subunits in the methyl CpG binding protein 2-null mouse brain. Neuroscience 168:624-632.
37. Matarazzo V, Cohen D, Palmer AM, Simpson PJ, Khokhar B, Pan SJ, Ronnett GV. 2004. The transcriptional repressor Mecp2 regulates terminal neuronal differentiation. Mol Cell Neurosci 27: 44-58.
38. Medrihan L, Tantalaki E, Aramuni G, Sargsyan V, Dudanova I, Missler M, Zhang W. 2008. Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome. J Neurophysiol 99: 112-121.
39. Moretti P, Levenson JM, Battaglia F, Atkinson R, Teague R, Antalffy B, Armstrong D, Arancio O, Sweatt JD, Zoghbi HY. 2006. Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome. J Neurosci 26: 319-327.
40. Mullaney BC, Johnston MV, Blue ME. 2004. Developmental expression of methyl-CpG binding protein 2 is dynamically regulated in the rodent brain. Neuroscience 123: 939-949.
41. Nagai M, Hoshide S, Kario K. 2010. The insular cortex and cardiovascular system: a new insight into the brain-heart axis. J Am Soc Hypertens 4: 174-182.
42. Naidu S. 1997. Rett syndrome: a disorder affecting early brain growth. Ann Neurol 42: 3-10.
43. Neul J, Kaufmann W, Glaze D, Christodoulou J, Clarke A, Bahi-Buisson N, Leonard H, Bailey M, Schanen N, Kerr A, Renieri A, Huppke P, Percy A, RettSearch Consortium 2010. Rett syndrome: revised diagnostic criteria and nomenclature. Ann Neurol 2010; 68: 944-950.
44. Palmer A, Qayumi J, Ronnett G. 2008. MeCP2 mutation causes distinguishable phases of acute and chronic defects in synaptogenesis and maintenance, respectively. Mol Cell Neurosci 37: 794-807.
45. 1H spectroscopic imaging at 4.1 Tesla. J Child Neurol 14: 524-528.
46. Rett A. 1966. On a unusual brain atrophy syndrome in hyperammonemia in childhood. Wien Med Wochenschr 116: 723-726.
47. Ronnett GV, Leopold D, Cai X, Hoffbuhr KC, Moses L, Hoffman EP, Naidu S. 2003. Olfactory biopsies demonstrate a defect in neuronal development in Rett's syndrome. Ann Neurol 54: 206-218.
48. Russell JC, Blue ME, Johnston MV, Naidu S, Hossain MA. 2007. Enhanced cell death in MeCP2 null cerebellar granule neurons exposed to excitotoxicity and hypoxia. Neuroscience 150: 563-574.
49. Saywell V, Viola A, Confort-Gouny S, Le Fur Y, Villard L, Cozzone PJ. 2006. Brain magnetic resonance study of Mecp2 deletion effects on anatomy and metabolism. Biochem Biophys Res Commun 340: 776-783.
50. Shahbazian M, Young J, Yuva-Paylor L, Spencer C, Antalffy B, Noebels J, Armstrong D, Paylor R, Zoghbi H. 2002. Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3. Neuron 35: 243-254.
51. Sirianni N, Naidu S, Pereira J, Pillotto RF, Hoffman EP. 1998. Rett syndrome: confirmation of X-linked dominant inheritance, and localization of the gene to Xq28. Am J Hum Genet 63: 1552-1558.
52. Sun HT, Cohen S, Kaufmann WE. 2001. Annexin-1 is abnormally expressed in fragile X syndrome: two-dimensional electrophoresis study in lymphocytes. Am J Med Genet 103: 81-90.
53. Viola A, Saywell V, Villard L, Cozzone PJ, Lutz NW. 2007. Metabolic fingerprints of altered brain growth, osmoregulation and neurotransmission in a Rett syndrome model. PLoS One 2: e157:1-9.
54. Ward BC, Agarwal S, Wang K, Berger-Sweeney J, Kolodny NH. 2008. Longitudinal brain MRI study in a mouse model of Rett Syndrome and the effects of choline. Neurobiol Dis 31: 110-119.
55. Wenk GL, Mobley SL. 1996. Choline acetyltransferase activity and vesamicol binding in Rett syndrome and in rats with nucleus basalis lesions. Neuroscience 73: 79-84.
56. Young JI, Zoghbi HY. 2004. X-chromosome inactivation patterns are unbalanced and affect the phenotypic outcome in a mouse model of rett syndrome. Am J Hum Genet 74: 511-520.
57. Zhang L, He J, Jugloff DG, Eubanks JH. 2008. The MeCP2-null mouse hippocampus displays altered basal inhibitory rhythms and is prone to hyperexcitability. Hippocampus 18: 294-309.
58. Zhang ZW, Zak JD, Liu H. 2010. MeCP2 is required for normal development of GABAergic circuits in the thalamus. J Neurophysiol 103:2470-2481.