메뉴 건너뛰기




Volumn 79, Issue 4, 2010, Pages 632-646

Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of Fragile X syndrome

Author keywords

Autism; FMR1; Glycogen synthase kinase 3; Lithium; MPEP

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; BRAIN DERIVED NEUROTROPHIC FACTOR; FRAGILE X MENTAL RETARDATION PROTEIN; GLYCOGEN SYNTHASE KINASE 3; LITHIUM CARBONATE; METABOTROPIC RECEPTOR;

EID: 71549145629     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.09.023     Document Type: Article
Times cited : (162)

References (64)
  • 3
    • 23944490213 scopus 로고    scopus 로고
    • Recent advances in fragile X: a model for autism and neurodegeneration
    • Hagerman R.J., Ono M.Y., and Hagerman P.J. Recent advances in fragile X: a model for autism and neurodegeneration. Curr Opin Psychiatry 18 (2005) 490-496
    • (2005) Curr Opin Psychiatry , vol.18 , pp. 490-496
    • Hagerman, R.J.1    Ono, M.Y.2    Hagerman, P.J.3
  • 4
    • 0028246435 scopus 로고
    • Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch-Belgian Fragile X Consortium
    • Bakker C.E., Verheij C., Willemsen R., van der Helm R., Oerlemans F., Vermey M., et al. Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch-Belgian Fragile X Consortium. Cell 78 (1994) 23-33
    • (1994) Cell , vol.78 , pp. 23-33
    • Bakker, C.E.1    Verheij, C.2    Willemsen, R.3    van der Helm, R.4    Oerlemans, F.5    Vermey, M.6
  • 5
    • 0037180564 scopus 로고    scopus 로고
    • Increased rates of cerebral glucose metabolism in a mouse model of fragile X mental retardation
    • Qin M., Kang J., and Smith C.B. Increased rates of cerebral glucose metabolism in a mouse model of fragile X mental retardation. Proc Natl Acad Sci USA 99 (2002) 15758-15763
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15758-15763
    • Qin, M.1    Kang, J.2    Smith, C.B.3
  • 6
    • 26044460532 scopus 로고    scopus 로고
    • A null mutation for Fmr1 in female mice: effects on regional cerebral metabolic rate for glucose and relationship to behavior
    • Qin M., Kang J., and Smith C.B. A null mutation for Fmr1 in female mice: effects on regional cerebral metabolic rate for glucose and relationship to behavior. Neuroscience 135 (2005) 999-1009
    • (2005) Neuroscience , vol.135 , pp. 999-1009
    • Qin, M.1    Kang, J.2    Smith, C.B.3
  • 7
    • 62649111481 scopus 로고    scopus 로고
    • Dissociation of social and nonsocial anxiety in a mouse model of fragile X syndrome
    • Liu Z.H., and Smith C.B. Dissociation of social and nonsocial anxiety in a mouse model of fragile X syndrome. Neurosci Lett 454 (2009) 62-66
    • (2009) Neurosci Lett , vol.454 , pp. 62-66
    • Liu, Z.H.1    Smith, C.B.2
  • 8
    • 31444443968 scopus 로고    scopus 로고
    • Social behavior deficits in the Fmr1 mutant mouse
    • Mineur Y.S., Huynh L.X., and Crusio W.E. Social behavior deficits in the Fmr1 mutant mouse. Behav Brain Res 168 (2006) 172-175
    • (2006) Behav Brain Res , vol.168 , pp. 172-175
    • Mineur, Y.S.1    Huynh, L.X.2    Crusio, W.E.3
  • 9
    • 26444548563 scopus 로고    scopus 로고
    • Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome
    • Spencer C.M., Alekseyenko O., Serysheva E., Yuva-Paylor L.A., and Paylor R. Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome. Genes Brain Behav 4 (2005) 420-430
    • (2005) Genes Brain Behav , vol.4 , pp. 420-430
    • Spencer, C.M.1    Alekseyenko, O.2    Serysheva, E.3    Yuva-Paylor, L.A.4    Paylor, R.5
  • 11
    • 20044388322 scopus 로고    scopus 로고
    • Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome
    • McBride S.M., Choi C.H., Wang Y., Liebelt D., Braunstein E., Ferreiro D., et al. Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome. Neuron 45 (2005) 753-764
    • (2005) Neuron , vol.45 , pp. 753-764
    • McBride, S.M.1    Choi, C.H.2    Wang, Y.3    Liebelt, D.4    Braunstein, E.5    Ferreiro, D.6
  • 12
    • 58849126410 scopus 로고    scopus 로고
    • Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential
    • Min W.W., Yuskaitis C.J., Yan Q., Sikorski C., Chen S., Jope R.S., et al. Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential. Neuropharmacology 56 (2009) 463-472
    • (2009) Neuropharmacology , vol.56 , pp. 463-472
    • Min, W.W.1    Yuskaitis, C.J.2    Yan, Q.3    Sikorski, C.4    Chen, S.5    Jope, R.S.6
  • 13
    • 0032947795 scopus 로고    scopus 로고
    • Anti-bipolar therapy: mechanism of action of lithium
    • Jope R.S. Anti-bipolar therapy: mechanism of action of lithium. Mol Psychiatry 4 (1999) 117-128
    • (1999) Mol Psychiatry , vol.4 , pp. 117-128
    • Jope, R.S.1
  • 15
    • 0037383322 scopus 로고    scopus 로고
    • GSK-3: tricks of the trade for a multi-tasking kinase
    • Doble B.W., and Woodgett J.R. GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci 116 (2003) 1175-1186
    • (2003) J Cell Sci , vol.116 , pp. 1175-1186
    • Doble, B.W.1    Woodgett, J.R.2
  • 16
    • 0442276554 scopus 로고    scopus 로고
    • The glamour and gloom of glycogen synthase kinase-3
    • Jope R.S., and Johnson G.V. The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci 29 (2004) 95-102
    • (2004) Trends Biochem Sci , vol.29 , pp. 95-102
    • Jope, R.S.1    Johnson, G.V.2
  • 17
    • 65649100104 scopus 로고    scopus 로고
    • Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development
    • Force T., and Woodgett J.R. Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development. J Biol Chem 284 (2009) 9643-9647
    • (2009) J Biol Chem , vol.284 , pp. 9643-9647
    • Force, T.1    Woodgett, J.R.2
  • 18
    • 33745444341 scopus 로고    scopus 로고
    • Targeting glycogen synthase kinase-3 in insulin signalling
    • Frame S., and Zheleva D. Targeting glycogen synthase kinase-3 in insulin signalling. Expert Opin Ther Targets 10 (2006) 429-444
    • (2006) Expert Opin Ther Targets , vol.10 , pp. 429-444
    • Frame, S.1    Zheleva, D.2
  • 19
    • 0029776032 scopus 로고    scopus 로고
    • A molecular mechanism for the effect of lithium on development
    • Klein P.S., and Melton D.A. A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci USA 93 (1996) 8455-8459
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 8455-8459
    • Klein, P.S.1    Melton, D.A.2
  • 20
    • 0030449964 scopus 로고    scopus 로고
    • Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
    • Stambolic V., Ruel L., and Woodgett J.R. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol 6 (1996) 1664-1668
    • (1996) Curr Biol , vol.6 , pp. 1664-1668
    • Stambolic, V.1    Ruel, L.2    Woodgett, J.R.3
  • 21
    • 0036909443 scopus 로고    scopus 로고
    • Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium
    • De Sarno P., Li X., and Jope R.S. Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium. Neuropharmacology 43 (2002) 1158-1164
    • (2002) Neuropharmacology , vol.43 , pp. 1158-1164
    • De Sarno, P.1    Li, X.2    Jope, R.S.3
  • 22
    • 0042379932 scopus 로고    scopus 로고
    • Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes
    • Jope R.S. Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes. Trends Pharmacol Sci 24 (2003) 441-443
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 441-443
    • Jope, R.S.1
  • 24
    • 24344457816 scopus 로고    scopus 로고
    • Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP
    • Yan Q.J., Rammal M., Tranfaglia M., and Bauchwitz R.P. Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP. Neuropharmacology 49 (2005) 1053-1066
    • (2005) Neuropharmacology , vol.49 , pp. 1053-1066
    • Yan, Q.J.1    Rammal, M.2    Tranfaglia, M.3    Bauchwitz, R.P.4
  • 26
    • 28844449366 scopus 로고    scopus 로고
    • The inhibition of glycogen synthase kinase 3beta by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Abeta peptides
    • Liu F., Gong X., Zhang G., Marquis K., Reinhart P., and Andree T.H. The inhibition of glycogen synthase kinase 3beta by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Abeta peptides. J Neurochem 95 (2005) 1363-1372
    • (2005) J Neurochem , vol.95 , pp. 1363-1372
    • Liu, F.1    Gong, X.2    Zhang, G.3    Marquis, K.4    Reinhart, P.5    Andree, T.H.6
  • 27
    • 3342955475 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3β haploinsufficiency mimics the behavioral and molecular effects of lithium
    • O'Brien W.T., Harper A.D., Jové F., Woodgett J.R., Maretto S., Piccolo S., et al. Glycogen synthase kinase-3β haploinsufficiency mimics the behavioral and molecular effects of lithium. J Neurosci 24 (2004) 6791-6798
    • (2004) J Neurosci , vol.24 , pp. 6791-6798
    • O'Brien, W.T.1    Harper, A.D.2    Jové, F.3    Woodgett, J.R.4    Maretto, S.5    Piccolo, S.6
  • 28
    • 2642552331 scopus 로고    scopus 로고
    • Lithium, a common drug for bipolar disorder treatment, regulates amyloid-β precursor protein processing
    • Su Y., Ryder J., Li B., Wu X., Fox N., Solenberg P., et al. Lithium, a common drug for bipolar disorder treatment, regulates amyloid-β precursor protein processing. Biochemistry 43 (2004) 6899-6908
    • (2004) Biochemistry , vol.43 , pp. 6899-6908
    • Su, Y.1    Ryder, J.2    Li, B.3    Wu, X.4    Fox, N.5    Solenberg, P.6
  • 29
    • 20944441740 scopus 로고    scopus 로고
    • The anti-apoptotic, glucocorticoid receptor cochaperone protein BAG-1 is a long-term target for the actions of mood stabilizers
    • Zhou R., Gray N.A., Yuan P., Li X., Chen J., Chen G., et al. The anti-apoptotic, glucocorticoid receptor cochaperone protein BAG-1 is a long-term target for the actions of mood stabilizers. J Neurosci 25 (2005) 4493-4502
    • (2005) J Neurosci , vol.25 , pp. 4493-4502
    • Zhou, R.1    Gray, N.A.2    Yuan, P.3    Li, X.4    Chen, J.5    Chen, G.6
  • 30
    • 84889487702 scopus 로고    scopus 로고
    • Lithium, the seminal GSK3 inhibitor
    • Martinez A., Castro A., and Medina M. (Eds), John Wiley and Sons, Inc.
    • Jope R.S. Lithium, the seminal GSK3 inhibitor. In: Martinez A., Castro A., and Medina M. (Eds). Glycogen synthase kinase 3 (GSK-3) and its inhibitors (2006), John Wiley and Sons, Inc. 223-242
    • (2006) Glycogen synthase kinase 3 (GSK-3) and its inhibitors , pp. 223-242
    • Jope, R.S.1
  • 31
    • 34249087808 scopus 로고    scopus 로고
    • Strain differences in lithium attenuation of d-amphetamine-induced hyperlocomotion: a mouse model for the genetics of clinical response to lithium
    • Gould T.D., O'Donnell K.C., Picchini A.M., and Manji H.K. Strain differences in lithium attenuation of d-amphetamine-induced hyperlocomotion: a mouse model for the genetics of clinical response to lithium. Neuropsychopharmacology 32 (2007) 1321-1333
    • (2007) Neuropsychopharmacology , vol.32 , pp. 1321-1333
    • Gould, T.D.1    O'Donnell, K.C.2    Picchini, A.M.3    Manji, H.K.4
  • 32
    • 40949090052 scopus 로고    scopus 로고
    • Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome
    • Dolen G., and Bear M.F. Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome. J Physiol 586 (2008) 1503-1508
    • (2008) J Physiol , vol.586 , pp. 1503-1508
    • Dolen, G.1    Bear, M.F.2
  • 33
    • 65949096495 scopus 로고    scopus 로고
    • A pilot open label, single dose trial of fenobam in adults with fragile X syndrome
    • Berry-Kravis E., Hessl D., Coffey S., Hervey C., Schneider A., Yuhas J., et al. A pilot open label, single dose trial of fenobam in adults with fragile X syndrome. J Med Genet 46 (2009) 266-271
    • (2009) J Med Genet , vol.46 , pp. 266-271
    • Berry-Kravis, E.1    Hessl, D.2    Coffey, S.3    Hervey, C.4    Schneider, A.5    Yuhas, J.6
  • 34
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies S.P., Reddy H., Caivano M., and Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351 (2000) 95-105
    • (2000) Biochem J , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 35
    • 51249098804 scopus 로고    scopus 로고
    • Open-label treatment trial of lithium to target the underlying defect in fragile X syndrome
    • Berry-Kravis E., Sumis A., Hervey C., Nelson M., Porges S.W., Weng N., et al. Open-label treatment trial of lithium to target the underlying defect in fragile X syndrome. J Dev Behav Pediatr 29 (2008) 293-302
    • (2008) J Dev Behav Pediatr , vol.29 , pp. 293-302
    • Berry-Kravis, E.1    Sumis, A.2    Hervey, C.3    Nelson, M.4    Porges, S.W.5    Weng, N.6
  • 37
    • 35148838569 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor rescues synaptic plasticity in a mouse model of fragile X syndrome
    • Lauterborn J.C., Rex C.S., Kramar E., Chen L.Y., Pandyarajan V., Lynch G., et al. Brain-derived neurotrophic factor rescues synaptic plasticity in a mouse model of fragile X syndrome. J Neurosci 27 (2007) 10685-10694
    • (2007) J Neurosci , vol.27 , pp. 10685-10694
    • Lauterborn, J.C.1    Rex, C.S.2    Kramar, E.3    Chen, L.Y.4    Pandyarajan, V.5    Lynch, G.6
  • 38
    • 0141927282 scopus 로고    scopus 로고
    • Lithium treatment alters brain concentrations of nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in a rat model of depression
    • Angelucci F., Aloe L., Jimenez-Vasquez P., and Mathe A.A. Lithium treatment alters brain concentrations of nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in a rat model of depression. Int J Neuropsychopharmacol 6 (2003) 225-231
    • (2003) Int J Neuropsychopharmacol , vol.6 , pp. 225-231
    • Angelucci, F.1    Aloe, L.2    Jimenez-Vasquez, P.3    Mathe, A.A.4
  • 39
    • 4644250763 scopus 로고    scopus 로고
    • The effect of escitalopram, desipramine, electroconvulsive seizures and lithium on brain-derived neurotrophic factor mRNA and protein expression in the rat brain and the correlation to 5-HT and 5-HIAA levels
    • Jacobsen J.P., and Mork A. The effect of escitalopram, desipramine, electroconvulsive seizures and lithium on brain-derived neurotrophic factor mRNA and protein expression in the rat brain and the correlation to 5-HT and 5-HIAA levels. Brain Res 1024 (2004) 183-192
    • (2004) Brain Res , vol.1024 , pp. 183-192
    • Jacobsen, J.P.1    Mork, A.2
  • 40
    • 58049196879 scopus 로고    scopus 로고
    • The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons
    • Yasuda S., Liang M.H., Marinova Z., Yahyavi A., and Chuang D.M. The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons. Mol Psychiatry 14 (2009) 51-59
    • (2009) Mol Psychiatry , vol.14 , pp. 51-59
    • Yasuda, S.1    Liang, M.H.2    Marinova, Z.3    Yahyavi, A.4    Chuang, D.M.5
  • 41
    • 0034194228 scopus 로고    scopus 로고
    • (Over)correction of FMR1 deficiency with YAC transgenics: behavioral and physical features
    • Peier A.M., McIlwain K.L., Kenneson A., Warren S.T., Paylor R., and Nelson D.L. (Over)correction of FMR1 deficiency with YAC transgenics: behavioral and physical features. Hum Mol Genet 9 (2000) 1145-1159
    • (2000) Hum Mol Genet , vol.9 , pp. 1145-1159
    • Peier, A.M.1    McIlwain, K.L.2    Kenneson, A.3    Warren, S.T.4    Paylor, R.5    Nelson, D.L.6
  • 42
    • 0036197452 scopus 로고    scopus 로고
    • Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse
    • Mineur Y.S., Sluyter F., de Wit S., Oostra B.A., and Crusio W.E. Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse. Hippocampus 12 (2002) 39-46
    • (2002) Hippocampus , vol.12 , pp. 39-46
    • Mineur, Y.S.1    Sluyter, F.2    de Wit, S.3    Oostra, B.A.4    Crusio, W.E.5
  • 44
    • 46449094508 scopus 로고    scopus 로고
    • Unaltered hormonal response to stress in a mouse model of fragile X syndrome
    • Qin M., and Smith C.B. Unaltered hormonal response to stress in a mouse model of fragile X syndrome. Psychoneuroendocrinology 33 (2008) 883-889
    • (2008) Psychoneuroendocrinology , vol.33 , pp. 883-889
    • Qin, M.1    Smith, C.B.2
  • 45
    • 62149089881 scopus 로고    scopus 로고
    • Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model
    • Bilousova T.V., Dansie L., Ngo M., Aye J., Charles J.R., Ethell D.W., et al. Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model. J Med Genet 46 (2009) 94-102
    • (2009) J Med Genet , vol.46 , pp. 94-102
    • Bilousova, T.V.1    Dansie, L.2    Ngo, M.3    Aye, J.4    Charles, J.R.5    Ethell, D.W.6
  • 46
    • 0029867314 scopus 로고    scopus 로고
    • A review of the validity and variability of the elevated plus-maze as an animal model of anxiety
    • Hogg S. A review of the validity and variability of the elevated plus-maze as an animal model of anxiety. Pharmacol Biochem Behav 54 (1996) 21-30
    • (1996) Pharmacol Biochem Behav , vol.54 , pp. 21-30
    • Hogg, S.1
  • 47
    • 43249118326 scopus 로고    scopus 로고
    • Rodent models of depression: forced swimming and tail suspension behavioral despair tests in rats and mice
    • [Chapter 8:Unit 8 10A]
    • Porsolt R.D., Brossard G., Hautbois C., and Roux S. Rodent models of depression: forced swimming and tail suspension behavioral despair tests in rats and mice. Curr Protoc Neurosci (2001) [Chapter 8:Unit 8 10A]
    • (2001) Curr Protoc Neurosci
    • Porsolt, R.D.1    Brossard, G.2    Hautbois, C.3    Roux, S.4
  • 48
    • 33750866196 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions
    • Jope R.S., and Roh M.S. Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions. Curr Drug Targets 7 (2006) 1421-1434
    • (2006) Curr Drug Targets , vol.7 , pp. 1421-1434
    • Jope, R.S.1    Roh, M.S.2
  • 49
    • 3042647610 scopus 로고    scopus 로고
    • The mGluR theory of fragile X mental retardation
    • Bear M.F., Huber K.M., and Warren S.T. The mGluR theory of fragile X mental retardation. Trends Neurosci 27 (2004) 370-377
    • (2004) Trends Neurosci , vol.27 , pp. 370-377
    • Bear, M.F.1    Huber, K.M.2    Warren, S.T.3
  • 50
    • 0037188502 scopus 로고    scopus 로고
    • Altered synaptic plasticity in a mouse model of fragile X mental retardation
    • Huber K.M., Gallagher S.M., Warren S.T., and Bear M.F. Altered synaptic plasticity in a mouse model of fragile X mental retardation. Proc Natl Acad Sci USA 99 (2002) 7746-7750
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 7746-7750
    • Huber, K.M.1    Gallagher, S.M.2    Warren, S.T.3    Bear, M.F.4
  • 51
    • 34848890329 scopus 로고    scopus 로고
    • Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors
    • Nakamoto M., Nalavadi V., Epstein M.P., Narayanan U., Bassell G.J., and Warren S.T. Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors. Proc Natl Acad Sci USA 104 (2007) 15537-15542
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 15537-15542
    • Nakamoto, M.1    Nalavadi, V.2    Epstein, M.P.3    Narayanan, U.4    Bassell, G.J.5    Warren, S.T.6
  • 52
    • 0038825269 scopus 로고    scopus 로고
    • In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine)
    • Anderson J.J., Bradbury M.J., Giracello D.R., Chapman D.F., Holtz G., Roppe J., et al. In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine). Eur J Pharmacol 473 (2003) 35-40
    • (2003) Eur J Pharmacol , vol.473 , pp. 35-40
    • Anderson, J.J.1    Bradbury, M.J.2    Giracello, D.R.3    Chapman, D.F.4    Holtz, G.5    Roppe, J.6
  • 53
    • 33646775275 scopus 로고    scopus 로고
    • Group I metabotropic receptor neuroprotection requires Akt and its substrates that govern FOXO3a, Bim, and beta-catenin during oxidative stress
    • Chong Z.Z., Li F., and Maiese K. Group I metabotropic receptor neuroprotection requires Akt and its substrates that govern FOXO3a, Bim, and beta-catenin during oxidative stress. Curr Neurovasc Res 3 (2006) 107-117
    • (2006) Curr Neurovasc Res , vol.3 , pp. 107-117
    • Chong, Z.Z.1    Li, F.2    Maiese, K.3
  • 54
    • 33748684592 scopus 로고    scopus 로고
    • Endogenously activated mGlu5 metabotropic glutamate receptors sustain the increase in c-Myc expression induced by leukaemia inhibitory factor in cultured mouse embryonic stem cells
    • Spinsanti P., De Vita T., Di Castro S., Storto M., Formisano P., Nicoletti F., et al. Endogenously activated mGlu5 metabotropic glutamate receptors sustain the increase in c-Myc expression induced by leukaemia inhibitory factor in cultured mouse embryonic stem cells. J Neurochem 99 (2006) 299-307
    • (2006) J Neurochem , vol.99 , pp. 299-307
    • Spinsanti, P.1    De Vita, T.2    Di Castro, S.3    Storto, M.4    Formisano, P.5    Nicoletti, F.6
  • 55
    • 25644434915 scopus 로고    scopus 로고
    • A reduced number of metabotropic glutamate subtype 5 receptors are associated with constitutive homer proteins in a mouse model of fragile X syndrome
    • Giuffrida R., Musumeci S., D'Antoni S., Bonaccorso C.M., Giuffrida-Stella A.M., Oostra B.A., et al. A reduced number of metabotropic glutamate subtype 5 receptors are associated with constitutive homer proteins in a mouse model of fragile X syndrome. J Neurosci 25 (2005) 8908-8916
    • (2005) J Neurosci , vol.25 , pp. 8908-8916
    • Giuffrida, R.1    Musumeci, S.2    D'Antoni, S.3    Bonaccorso, C.M.4    Giuffrida-Stella, A.M.5    Oostra, B.A.6
  • 56
    • 38349029199 scopus 로고    scopus 로고
    • Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation
    • Ronesi J.A., and Huber K.M. Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation. J Neurosci 28 (2008) 543-547
    • (2008) J Neurosci , vol.28 , pp. 543-547
    • Ronesi, J.A.1    Huber, K.M.2
  • 57
    • 56249091722 scopus 로고    scopus 로고
    • Multifaceted strain-specific effects in a mouse model of depression and of antidepressant reversal
    • Ibarguen-Vargas Y., Surget A., Touma C., Palme R., and Belzung C. Multifaceted strain-specific effects in a mouse model of depression and of antidepressant reversal. Psychoneuroendocrinology 33 (2008) 1357-1368
    • (2008) Psychoneuroendocrinology , vol.33 , pp. 1357-1368
    • Ibarguen-Vargas, Y.1    Surget, A.2    Touma, C.3    Palme, R.4    Belzung, C.5
  • 59
    • 33748981282 scopus 로고    scopus 로고
    • Fmr1 KO mice as a possible model of autistic features
    • Bernardet M., and Crusio W.E. Fmr1 KO mice as a possible model of autistic features. ScientificWorldJournal 6 (2006) 1164-1176
    • (2006) ScientificWorldJournal , vol.6 , pp. 1164-1176
    • Bernardet, M.1    Crusio, W.E.2
  • 61
    • 0034795827 scopus 로고    scopus 로고
    • Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain
    • Fukumoto T., Morinobu S., Okamoto Y., Kagaya A., and Yamawaki S. Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain. Psychopharmacology (Berl) 158 (2001) 100-106
    • (2001) Psychopharmacology (Berl) , vol.158 , pp. 100-106
    • Fukumoto, T.1    Morinobu, S.2    Okamoto, Y.3    Kagaya, A.4    Yamawaki, S.5
  • 62
    • 33748280959 scopus 로고    scopus 로고
    • Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania
    • Prickaerts J., Moechars D., Cryns K., Lenaerts I., van Craenendonck H., Goris I., et al. Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania. J Neurosci 26 (2006) 9022-9029
    • (2006) J Neurosci , vol.26 , pp. 9022-9029
    • Prickaerts, J.1    Moechars, D.2    Cryns, K.3    Lenaerts, I.4    van Craenendonck, H.5    Goris, I.6
  • 63
    • 0037039527 scopus 로고    scopus 로고
    • Alterations in the auditory startle response in Fmr1 targeted mutant mouse models of fragile X syndrome
    • Nielsen D.M., Derber W.J., McClellan D.A., and Crnic L.S. Alterations in the auditory startle response in Fmr1 targeted mutant mouse models of fragile X syndrome. Brain Res 927 (2002) 8-17
    • (2002) Brain Res , vol.927 , pp. 8-17
    • Nielsen, D.M.1    Derber, W.J.2    McClellan, D.A.3    Crnic, L.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.