-
1
-
-
35848946909
-
The pathophysiology of fragile x syndrome
-
Penagarikano, O., Mulle, J.G. & Warren, S.T. The pathophysiology of fragile x syndrome. Annu. Rev. Genomics Hum. Genet. 8, 109-129 (2007).
-
(2007)
Annu. Rev. Genomics Hum. Genet
, vol.8
, pp. 109-129
-
-
Penagarikano, O.1
Mulle, J.G.2
Warren, S.T.3
-
2
-
-
0031310667
-
FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association
-
Feng, Y. et al. FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association. Mol. Cell 1, 109-118 (1997).
-
(1997)
Mol. Cell
, vol.1
, pp. 109-118
-
-
Feng, Y.1
-
3
-
-
0345492360
-
The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95
-
Todd, P.K., Mack, K.J. & Malter, J.S. The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95. Proc. Natl. Acad. Sci. USA 100, 14374-14378 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 14374-14378
-
-
Todd, P.K.1
Mack, K.J.2
Malter, J.S.3
-
4
-
-
18044379515
-
Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome
-
Brown, V. et al. Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell 107, 477-487 (2001).
-
(2001)
Cell
, vol.107
, pp. 477-487
-
-
Brown, V.1
-
5
-
-
0035900649
-
Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function
-
Darnell, J.C. et al. Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell 107, 489-499 (2001).
-
(2001)
Cell
, vol.107
, pp. 489-499
-
-
Darnell, J.C.1
-
6
-
-
2942532624
-
The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesis
-
Zhang, Y.Q. et al. The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesis. Dev. Biol. 270, 290-307 (2004).
-
(2004)
Dev. Biol
, vol.270
, pp. 290-307
-
-
Zhang, Y.Q.1
-
7
-
-
6344276563
-
The fragile X protein controls microtubule- associated protein 1B translation and microtubule stability in brain neuron development
-
Lu, R. et al. The fragile X protein controls microtubule- associated protein 1B translation and microtubule stability in brain neuron development. Proc. Natl. Acad. Sci. USA 101, 15201-15206 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 15201-15206
-
-
Lu, R.1
-
8
-
-
7944232720
-
RNA and microRNAs in fragile X mental retardation
-
Jin, P., Alisch, R.S. & Warren, S.T. RNA and microRNAs in fragile X mental retardation. Nat. Cell Biol. 6, 1048-1053 (2004).
-
(2004)
Nat. Cell Biol
, vol.6
, pp. 1048-1053
-
-
Jin, P.1
Alisch, R.S.2
Warren, S.T.3
-
9
-
-
3042647610
-
The mGluR theory of fragile X mental retardation
-
Bear, M.F., Huber, K.M. & Warren, S.T. The mGluR theory of fragile X mental retardation. Trends Neurosci. 27, 370-377 (2004).
-
(2004)
Trends Neurosci
, vol.27
, pp. 370-377
-
-
Bear, M.F.1
Huber, K.M.2
Warren, S.T.3
-
10
-
-
23944520830
-
Differential translation and fragile X syndrome
-
Vanderklish, P.W. & Edelman, G.M. Differential translation and fragile X syndrome. Genes Brain Behav. 4, 360-384 (2005).
-
(2005)
Genes Brain Behav
, vol.4
, pp. 360-384
-
-
Vanderklish, P.W.1
Edelman, G.M.2
-
11
-
-
24344457816
-
Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP
-
Yan, Q.J., Rammal, M., Tranfaglia, M. & Bauchwitz, R.P. Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP. Neuropharmacology 49, 1053-1066 (2005).
-
(2005)
Neuropharmacology
, vol.49
, pp. 1053-1066
-
-
Yan, Q.J.1
Rammal, M.2
Tranfaglia, M.3
Bauchwitz, R.P.4
-
12
-
-
20044388322
-
Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile x syndrome
-
McBride, S.M. et al. Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile x syndrome. Neuron 45, 753-764 (2005).
-
(2005)
Neuron
, vol.45
, pp. 753-764
-
-
McBride, S.M.1
-
13
-
-
0037071887
-
Understanding fragile X syndrome: Insights from retarded flies
-
Gao, F.B. Understanding fragile X syndrome: insights from retarded flies. Neuron 34, 859-862 (2002).
-
(2002)
Neuron
, vol.34
, pp. 859-862
-
-
Gao, F.B.1
-
14
-
-
0033761489
-
Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein
-
Wan, L., Dockendorff, T.C., Jongens, T.A. & Dreyfuss, G. Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein. Mol. Cell. Biol. 20, 8536-8547 (2000).
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 8536-8547
-
-
Wan, L.1
Dockendorff, T.C.2
Jongens, T.A.3
Dreyfuss, G.4
-
15
-
-
0345308602
-
Control of dendritic development by the Drosophila fragile X-related gene involves the small GTPase Rac1
-
Lee, A. et al. Control of dendritic development by the Drosophila fragile X-related gene involves the small GTPase Rac1. Development 130, 5543-5552 (2003).
-
(2003)
Development
, vol.130
, pp. 5543-5552
-
-
Lee, A.1
-
16
-
-
0035977134
-
Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function
-
Zhang, Y.Q. et al. Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. Cell 107, 591-603 (2001).
-
(2001)
Cell
, vol.107
, pp. 591-603
-
-
Zhang, Y.Q.1
-
17
-
-
20544468497
-
The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain
-
Reeve, S.P. et al. The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain. Curr. Biol. 15, 1156-1163 (2005).
-
(2005)
Curr. Biol
, vol.15
, pp. 1156-1163
-
-
Reeve, S.P.1
-
18
-
-
0037071888
-
Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain
-
Morales, J. et al. Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain. Neuron 34, 961-972 (2002).
-
(2002)
Neuron
, vol.34
, pp. 961-972
-
-
Morales, J.1
-
19
-
-
0037071905
-
Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest
-
Dockendorff, T.C. et al. Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest. Neuron 34, 973-984 (2002).
-
(2002)
Neuron
, vol.34
, pp. 973-984
-
-
Dockendorff, T.C.1
-
20
-
-
3042735950
-
Defective neuronal development in the mushroom bodies of Drosophila fragile X mental retardation 1 mutants
-
Michel, C.I., Kraft, R. & Restifo, L.L. Defective neuronal development in the mushroom bodies of Drosophila fragile X mental retardation 1 mutants. J. Neurosci. 24, 5798-5809 (2004).
-
(2004)
J. Neurosci
, vol.24
, pp. 5798-5809
-
-
Michel, C.I.1
Kraft, R.2
Restifo, L.L.3
-
21
-
-
6944247816
-
The Drosophila fragile x gene negatively regulates neuronal elaboration and synaptic differentiation
-
Pan, L., Zhang, Y.Q., Woodruff, E. & Broadie, K. The Drosophila fragile x gene negatively regulates neuronal elaboration and synaptic differentiation. Curr. Biol. 14, 1863-1870 (2004).
-
(2004)
Curr. Biol
, vol.14
, pp. 1863-1870
-
-
Pan, L.1
Zhang, Y.Q.2
Woodruff, E.3
Broadie, K.4
-
22
-
-
0033864480
-
GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects
-
Krogsgaard-Larsen, P., Frolund, B. & Frydenvang, K. GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects. Curr. Pharm. Des. 6, 1193-1209 (2000).
-
(2000)
Curr. Pharm. Des
, vol.6
, pp. 1193-1209
-
-
Krogsgaard-Larsen, P.1
Frolund, B.2
Frydenvang, K.3
-
23
-
-
39049187608
-
The importance of company: Na+ and Cl- influence substrate interaction with SLC6 transporters and other proteins
-
Reith, M.E., Zhen, J. & Chen, N. The importance of company: Na+ and Cl- influence substrate interaction with SLC6 transporters and other proteins. Handb. Exp. Pharmacol. 75-93 (2006).
-
(2006)
Handb. Exp. Pharmacol
, pp. 75-93
-
-
Reith, M.E.1
Zhen, J.2
Chen, N.3
-
24
-
-
33745068751
-
Food for thought: Honeybee foraging, memory, and acetylcholine
-
pe23 2006
-
Weinberger, N.M. Food for thought: honeybee foraging, memory, and acetylcholine. Sci. STKE 2006, pe23 (2006).
-
(2006)
Sci. STKE
-
-
Weinberger, N.M.1
-
25
-
-
30444432203
-
Stimulation of muscarinic receptors mimics experience-dependent plasticity in the honey bee brain
-
Ismail, N., Robinson, G.E. & Fahrbach, S.E. Stimulation of muscarinic receptors mimics experience-dependent plasticity in the honey bee brain. Proc. Natl. Acad. Sci. USA 103, 207-211 (2006).
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 207-211
-
-
Ismail, N.1
Robinson, G.E.2
Fahrbach, S.E.3
-
26
-
-
34547411880
-
Propagation of olfactory information in Drosophila
-
Root, C.M., Semmelhack, J.L., Wong, A.M., Flores, J. & Wang, J.W. Propagation of olfactory information in Drosophila. Proc. Natl. Acad. Sci. USA 104, 11826-11831 (2007).
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 11826-11831
-
-
Root, C.M.1
Semmelhack, J.L.2
Wong, A.M.3
Flores, J.4
Wang, J.W.5
-
27
-
-
27144466423
-
Role of GABAergic inhibition in shaping odor-evoked spatiotemporal patterns in the Drosophila antennal lobe
-
Wilson, R.I. & Laurent, G. Role of GABAergic inhibition in shaping odor-evoked spatiotemporal patterns in the Drosophila antennal lobe. J. Neurosci. 25, 9069-9079 (2005).
-
(2005)
J. Neurosci
, vol.25
, pp. 9069-9079
-
-
Wilson, R.I.1
Laurent, G.2
-
28
-
-
0038439322
-
Mushroom body memoir: From maps to models
-
Heisenberg, M. Mushroom body memoir: from maps to models. Nat. Rev. Neurosci. 4, 266-275 (2003).
-
(2003)
Nat. Rev. Neurosci
, vol.4
, pp. 266-275
-
-
Heisenberg, M.1
-
29
-
-
0028360968
-
The mating of a fly
-
Hall, J.C. The mating of a fly. Science 264, 1702-1714 (1994).
-
(1994)
Science
, vol.264
, pp. 1702-1714
-
-
Hall, J.C.1
-
30
-
-
0018413205
-
Conditioned responses in courtship behavior of normal and mutant Drosophila
-
Siegel, R.W. & Hall, J.C. Conditioned responses in courtship behavior of normal and mutant Drosophila. Proc. Natl. Acad. Sci. USA 76, 3430-3434 (1979).
-
(1979)
Proc. Natl. Acad. Sci. USA
, vol.76
, pp. 3430-3434
-
-
Siegel, R.W.1
Hall, J.C.2
-
31
-
-
33747130379
-
Altered synaptic function in Alzheimer's disease
-
Bell, K.F. & Claudio Cuello, A. Altered synaptic function in Alzheimer's disease. Eur. J. Pharmacol. 545, 11-21 (2006).
-
(2006)
Eur. J. Pharmacol
, vol.545
, pp. 11-21
-
-
Bell, K.F.1
Claudio Cuello, A.2
-
32
-
-
33745239787
-
Biologically active molecules that reduce polyglutamine aggregation and toxicity
-
Desai, U.A. et al. Biologically active molecules that reduce polyglutamine aggregation and toxicity. Hum. Mol. Genet. 15, 2114-2124 (2006).
-
(2006)
Hum. Mol. Genet
, vol.15
, pp. 2114-2124
-
-
Desai, U.A.1
-
33
-
-
33845789522
-
Forward chemical genetic approach identifies new role for GAPDH in insulin signaling
-
Min, J. et al. Forward chemical genetic approach identifies new role for GAPDH in insulin signaling. Nat. Chem. Biol. 3, 55-59 (2007).
-
(2007)
Nat. Chem. Biol
, vol.3
, pp. 55-59
-
-
Min, J.1
-
34
-
-
33745912507
-
Identification of novel antimicrobials using a live-animal infection model
-
Moy, T.I. et al. Identification of novel antimicrobials using a live-animal infection model. Proc. Natl. Acad. Sci. USA 103, 10414-10419 (2006).
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 10414-10419
-
-
Moy, T.I.1
-
35
-
-
34248598584
-
-
Segalat, L. Invertebrate animal models of diseases as screening tools in drug discovery. ACS Chem. Biol. 2, 231-236 (2007).
-
Segalat, L. Invertebrate animal models of diseases as screening tools in drug discovery. ACS Chem. Biol. 2, 231-236 (2007).
-
-
-
-
36
-
-
23944519979
-
The interaction between the cholinergic and dopaminergic system in learning and memory process in rats
-
Hefco, V. et al. The interaction between the cholinergic and dopaminergic system in learning and memory process in rats. Rom. J. Physiol. 41, 21-30 (2004).
-
(2004)
Rom. J. Physiol
, vol.41
, pp. 21-30
-
-
Hefco, V.1
-
37
-
-
3242810417
-
Nucleus accumbens acetylcholine regulates appetitive learning and motivation for food via activation of muscarinic receptors
-
Pratt, W.E. & Kelley, A.E. Nucleus accumbens acetylcholine regulates appetitive learning and motivation for food via activation of muscarinic receptors. Behav. Neurosci. 118, 730-739 (2004).
-
(2004)
Behav. Neurosci
, vol.118
, pp. 730-739
-
-
Pratt, W.E.1
Kelley, A.E.2
-
38
-
-
0042575347
-
Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice
-
Tzavara, E.T. et al. Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice. Mol. Psychiatry 8, 673-679 (2003).
-
(2003)
Mol. Psychiatry
, vol.8
, pp. 673-679
-
-
Tzavara, E.T.1
-
39
-
-
19444366814
-
Genetic deletion of CB1 receptors improves non-associative learning
-
Degroot, A., Salhoff, C., Davis, R.J. & Nomikos, G.G. Genetic deletion of CB1 receptors improves non-associative learning. Behav. Brain Res. 162, 161-164 (2005).
-
(2005)
Behav. Brain Res
, vol.162
, pp. 161-164
-
-
Degroot, A.1
Salhoff, C.2
Davis, R.J.3
Nomikos, G.G.4
-
40
-
-
0034939477
-
Memory impairment induced by cholinergic antagonists injected into the mushroom bodies of the honeybee
-
Lozano, V.C., Armengaud, C. & Gauthier, M. Memory impairment induced by cholinergic antagonists injected into the mushroom bodies of the honeybee. J. Comp. Physiol. [A] 187, 249-254 (2001).
-
(2001)
J. Comp. Physiol. [A]
, vol.187
, pp. 249-254
-
-
Lozano, V.C.1
Armengaud, C.2
Gauthier, M.3
-
41
-
-
33750726094
-
Decreased expression of the GABAA receptor in fragile X syndrome
-
D'Hulst, C. et al. Decreased expression of the GABAA receptor in fragile X syndrome. Brain Res. 1121, 238-245 (2006).
-
(2006)
Brain Res
, vol.1121
, pp. 238-245
-
-
D'Hulst, C.1
-
42
-
-
30744433092
-
Expression profiling suggests underexpression of the GABA(A) receptor subunit delta in the fragile X knockout mouse model
-
Gantois, I. et al. Expression profiling suggests underexpression of the GABA(A) receptor subunit delta in the fragile X knockout mouse model. Neurobiol. Dis. 21, 346-357 (2006).
-
(2006)
Neurobiol. Dis
, vol.21
, pp. 346-357
-
-
Gantois, I.1
-
43
-
-
14744291567
-
Decreased GABA(A) receptor expression in the seizure-prone fragile X mouse
-
El Idrissi, A. et al. Decreased GABA(A) receptor expression in the seizure-prone fragile X mouse. Neurosci. Lett. 377, 141-146 (2005).
-
(2005)
Neurosci. Lett
, vol.377
, pp. 141-146
-
-
El Idrissi, A.1
-
44
-
-
33846238191
-
Major defects in neocortical GABAergic inhibitory circuits in mice lacking the fragile X mental retardation protein
-
Selby, L., Zhang, C. & Sun, Q.Q. Major defects in neocortical GABAergic inhibitory circuits in mice lacking the fragile X mental retardation protein. Neurosci. Lett. 412, 227-232 (2007).
-
(2007)
Neurosci. Lett
, vol.412
, pp. 227-232
-
-
Selby, L.1
Zhang, C.2
Sun, Q.Q.3
-
45
-
-
0038345688
-
Formation of dendritic spines in cultured striatal neurons depends on excitatory afferent activity
-
Segal, M., Greenberger, V. & Korkotian, E. Formation of dendritic spines in cultured striatal neurons depends on excitatory afferent activity. Eur. J. Neurosci. 17, 2573-2585 (2003).
-
(2003)
Eur. J. Neurosci
, vol.17
, pp. 2573-2585
-
-
Segal, M.1
Greenberger, V.2
Korkotian, E.3
-
46
-
-
0030963294
-
γ-Aminobutyric acid receptor distribution in the mushroom bodies of a fly (Calliphora erythrocephala): A functional subdivision of Kenyon cells?
-
Brotz, T.M., Bochenek, B., Aronstein, K., Ffrench-Constant, R.H. & Borst, A. γ-Aminobutyric acid receptor distribution in the mushroom bodies of a fly (Calliphora erythrocephala): a functional subdivision of Kenyon cells? J. Comp. Neurol. 383, 42-48 (1997).
-
(1997)
J. Comp. Neurol
, vol.383
, pp. 42-48
-
-
Brotz, T.M.1
Bochenek, B.2
Aronstein, K.3
Ffrench-Constant, R.H.4
Borst, A.5
-
47
-
-
0032458798
-
Immunocytochemical mapping of an RDL-like GABA receptor subunit and of GABA in brain structures related to learning and memory in the cricket Acheta domesticus
-
Strambi, C. et al. Immunocytochemical mapping of an RDL-like GABA receptor subunit and of GABA in brain structures related to learning and memory in the cricket Acheta domesticus. Learn. Mem. 5, 78-89 (1998).
-
(1998)
Learn. Mem
, vol.5
, pp. 78-89
-
-
Strambi, C.1
-
48
-
-
0032579863
-
Three classes of GABA-like immunoreactive neurons in the mushroom body of the cockroach
-
Yamazaki, Y., Nishikawa, M. & Mizunami, M. Three classes of GABA-like immunoreactive neurons in the mushroom body of the cockroach. Brain Res. 788, 80-86 (1998).
-
(1998)
Brain Res
, vol.788
, pp. 80-86
-
-
Yamazaki, Y.1
Nishikawa, M.2
Mizunami, M.3
-
49
-
-
17544404660
-
Glutamate-like immunoreactivity marks compartments of the mushroom bodies in the brain of the cricket
-
Schurmann, F.W., Ottersen, O.P. & Honegger, H.W. Glutamate-like immunoreactivity marks compartments of the mushroom bodies in the brain of the cricket. J. Comp. Neurol. 418, 227-239 (2000).
-
(2000)
J. Comp. Neurol
, vol.418
, pp. 227-239
-
-
Schurmann, F.W.1
Ottersen, O.P.2
Honegger, H.W.3
-
50
-
-
0029931883
-
Courtship anomalies caused by doublesex mutations in Drosophila melanogaster
-
Villella, A. & Hall, J.C. Courtship anomalies caused by doublesex mutations in Drosophila melanogaster. Genetics 143, 331-344 (1996).
-
(1996)
Genetics
, vol.143
, pp. 331-344
-
-
Villella, A.1
Hall, J.C.2
|