Glycogen synthase kinase-3 inhibitors reverse deficits in long-term potentiation and cognition in fragile X mice

Biological Psychiatry

Volumn 75, Issue 3, 2014, Pages 198-206

  Franklin, Aimee V ^a   King, Margaret K ^a   Palomo, Valle ^c   Martinez, Ana ^c   McMahon, Lori L ^a   Jope, Richard S ^b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

Cognition; fragile X syndrome; glycogen synthase kinase 3; learning; long term potentiation (LTP); synaptic plasticity

Indexed keywords

CT 99021; DIMETHYL SULFOXIDE; GLYCOGEN SYNTHASE KINASE 3; LITHIUM CHLORIDE; MOOD STABILIZER; N' DODECANOYL 1 ETHYL 4 HYDROXY 2 OXO 1,2 DIHYDROQUINOLINEL 3 CARBOHYDRAZIDE; PICROTOXIN; THIADIAZOLIDINDIONE 8; UNCLASSIFIED DRUG; VP 07;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN SLICE; COGNITION; COGNITIVE DEFECT; DENTATE GYRUS; ENZYME INHIBITION; FRAGILE X SYNDROME; GRANULE CELL; HIPPOCAMPUS; LONG TERM POTENTIATION; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; SYNAPTOSOME;

COGNITION; FRAGILE X SYNDROME; GLYCOGEN SYNTHASE KINASE-3; LEARNING; LONG-TERM POTENTIATION (LTP); SYNAPTIC PLASTICITY;

ANIMALS; COGNITION; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; EXCITATORY AMINO ACID ANTAGONISTS; FRAGILE X MENTAL RETARDATION PROTEIN; FRAGILE X SYNDROME; GLYCOGEN SYNTHASE KINASE 3; GUANYLATE KINASE; HIPPOCAMPUS; LITHIUM CHLORIDE; LONG-TERM POTENTIATION; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; PATCH-CLAMP TECHNIQUES; PROTEIN KINASE INHIBITORS; SYNAPSES;

EID: 84891593130     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2013.08.003     Document Type: Article

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