-
1
-
-
39849102665
-
Altered protein synthesis is a trigger for long-Term memory formation
-
Klann, E. & Sweatt, J.D. Altered protein synthesis is a trigger for long-Term memory formation. Neurobiol. Learn. Mem. 89, 247-259 (2008
-
(2008)
Neurobiol. Learn. Mem
, vol.89
, pp. 247-259
-
-
Klann, E.1
Sweatt, J.D.2
-
2
-
-
84862637069
-
The pathophysiology of fragile X (and what it teaches us about synapses
-
Bhakar, A.L., Dolen, G. & Bear, M.F. The pathophysiology of fragile X (and what it teaches us about synapses). Annu. Rev. Neurosci. 35, 417-443 (2012
-
(2012)
Annu. Rev. Neurosci
, vol.35
, pp. 417-443
-
-
Bhakar, A.L.1
Dolen, G.2
Bear, M.F.3
-
3
-
-
84856879093
-
Molecular mechanisms of fragile X syndrome: A twenty-year perspective
-
Santoro, M.R., Bray, S.M. & Warren, S.T. Molecular mechanisms of fragile X syndrome: A twenty-year perspective. Annu. Rev. Pathol. 7, 219-245 (2012
-
(2012)
Annu. Rev. Pathol
, vol.7
, pp. 219-245
-
-
Santoro, M.R.1
Bray, S.M.2
Warren, S.T.3
-
4
-
-
66149123016
-
The fragile X mental retardation protein in circadian rhythmicity and memory consolidation
-
Gatto, C.L. & Broadie, K. The fragile X mental retardation protein in circadian rhythmicity and memory consolidation. Mol. Neurobiol. 39, 107-129 (2009
-
(2009)
Mol. Neurobiol
, vol.39
, pp. 107-129
-
-
Gatto, C.L.1
Broadie, K.2
-
5
-
-
0030986183
-
Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits
-
Comery, T.A. et al. Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits. Proc. Natl. Acad. Sci. USA 94, 5401-5404 (1997
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 5401-5404
-
-
Comery, T.A.1
-
6
-
-
0035879180
-
Abnormal development of dendritic spines in FMR1 knock-out mice
-
Nimchinsky, E.A., Oberlander, A.M. & Svoboda, K. Abnormal development of dendritic spines in FMR1 knock-out mice. J. Neurosci. 21, 5139-5146 (2001
-
(2001)
J Neurosci
, vol.21
, pp. 5139-5146
-
-
Nimchinsky, E.A.1
Oberlander, A.M.2
Svoboda, K.3
-
7
-
-
77953528456
-
Delayed stabilization of dendritic spines in fragile X mice
-
Cruz-Martin, A., Crespo, M. & Portera-Cailliau, C. Delayed stabilization of dendritic spines in fragile X mice. J. Neurosci. 30, 7793-7803 (2010
-
(2010)
J Neurosci
, vol.30
, pp. 7793-7803
-
-
Cruz-Martin, A.1
Crespo, M.2
Portera-Cailliau, C.3
-
8
-
-
78049262158
-
Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile X syndrome
-
Pan, F., Aldridge, G.M., Greenough, W.T. & Gan, W.B. Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile X syndrome. Proc. Natl. Acad. Sci. USA 107, 17768-17773 (2010
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 17768-17773
-
-
Pan, F.1
Aldridge, G.M.2
Greenough, W.T.3
Gan, W.B.4
-
9
-
-
33646194363
-
Metabotropic receptor-dependent long-Term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome
-
Nosyreva, E.D. & Huber, K.M. Metabotropic receptor-dependent long-Term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome. J. Neurophysiol. 95, 3291-3295 (2006
-
(2006)
J Neurophysiol
, vol.95
, pp. 3291-3295
-
-
Nosyreva, E.D.1
Huber, K.M.2
-
10
-
-
33746866693
-
Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-Term depression
-
Hou, L. et al. Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-Term depression. Neuron 51, 441-454 (2006
-
(2006)
Neuron
, vol.51
, pp. 441-454
-
-
Hou, L.1
-
11
-
-
75949119188
-
Critical period plasticity is disrupted in the barrel cortex of FMR1 knockout mice
-
Harlow, E.G. et al. Critical period plasticity is disrupted in the barrel cortex of FMR1 knockout mice. Neuron 65, 385-398 (2010
-
(2010)
Neuron
, vol.65
, pp. 385-398
-
-
Harlow, E.G.1
-
12
-
-
84860473697
-
Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome
-
Till, S.M. et al. Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome. Hum. Mol. Genet. 21, 2143-2156 (2012
-
(2012)
Hum. Mol. Genet
, vol.21
, pp. 2143-2156
-
-
Till, S.M.1
-
13
-
-
59649126241
-
The FXG: A presynaptic fragile X granule expressed in a subset of developing brain circuits
-
Christie, S.B., Akins, M.R., Schwob, J.E. & Fallon, J.R. The FXG: A presynaptic fragile X granule expressed in a subset of developing brain circuits. J. Neurosci. 29, 1514-1524 (2009
-
(2009)
J. Neurosci
, vol.29
, pp. 1514-1524
-
-
Christie, S.B.1
Akins, M.R.2
Schwob, J.E.3
Fallon, J.R.4
-
14
-
-
7244224871
-
Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells
-
Stefani, G., Fraser, C.E., Darnell, J.C. & Darnell, R.B. Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells. J. Neurosci. 24, 7272-7276 (2004
-
(2004)
J. Neurosci
, vol.24
, pp. 7272-7276
-
-
Stefani, G.1
Fraser, C.E.2
Darnell, J.C.3
Darnell, R.B.4
-
15
-
-
4444238669
-
Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticles
-
Khandjian, E.W. et al. Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticles. Proc. Natl. Acad. Sci. USA 101, 13357-13362 (2004
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 13357-13362
-
-
Khandjian, E.W.1
-
16
-
-
79960779323
-
FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
-
Darnell, J.C. et al. FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism. Cell 146, 247-261 (2011
-
(2011)
Cell
, vol.146
, pp. 247-261
-
-
Darnell, J.C.1
-
17
-
-
0025905795
-
Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome
-
Verkerk, A.J. et al. Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell 65, 905-914 (1991
-
(1991)
Cell
, vol.65
, pp. 905-914
-
-
Verkerk, A.J.1
-
18
-
-
0027327486
-
The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein
-
Siomi, H., Siomi, M.C., Nussbaum, R.L. & Dreyfuss, G. The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein. Cell 74, 291-298 (1993
-
(1993)
Cell
, vol.74
, pp. 291-298
-
-
Siomi, H.1
Siomi, M.C.2
Nussbaum, R.L.3
Dreyfuss, G.4
-
19
-
-
0027509234
-
A point mutation in the FMR-1 gene associated with fragile X mental retardation
-
De Boulle, K. et al. A point mutation in the FMR-1 gene associated with fragile X mental retardation. Nat. Genet. 3, 31-35 (1993
-
(1993)
Nat. Genet
, vol.3
, pp. 31-35
-
-
De Boulle, K.1
-
20
-
-
0034603208
-
Sequence-specific RNA binding by a Nova KH domain: Implications for paraneoplastic disease and the fragile X syndrome
-
Lewis, H.A. et al. Sequence-specific RNA binding by a Nova KH domain: Implications for paraneoplastic disease and the fragile X syndrome. Cell 100, 323-332 (2000
-
(2000)
Cell
, vol.100
, pp. 323-332
-
-
Lewis, H.A.1
-
21
-
-
0031310667
-
FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association
-
Feng, Y. et al. FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association. Mol. Cell 1, 109-118 (1997
-
(1997)
Mol. Cell
, vol.1
, pp. 109-118
-
-
Feng, Y.1
-
22
-
-
74249093220
-
A mouse model of the human Fragile X syndrome I304N mutation
-
Zang, J.B. et al. A mouse model of the human Fragile X syndrome I304N mutation. PLoS Genet. 5, e1000758 (2009
-
(2009)
PLoS Genet
, vol.5
-
-
Zang, J.B.1
-
23
-
-
52949109182
-
Excess protein synthesis in Drosophila fragile X mutants impairs long-Term memory
-
Bolduc, F.V., Bell, K., Cox, H., Broadie, K.S. & Tully, T. Excess protein synthesis in Drosophila fragile X mutants impairs long-Term memory. Nat. Neurosci. 11, 1143-1145 (2008
-
(2008)
Nat. Neurosci
, vol.11
, pp. 1143-1145
-
-
Bolduc, F.V.1
Bell, K.2
Cox, H.3
Broadie, K.S.4
Tully, T.5
-
24
-
-
0037371441
-
The role of a clinically important mutation in the fold and RNA-binding properties of KH motifs
-
Ramos, A., Hollingworth, D. & Pastore, A. The role of a clinically important mutation in the fold and RNA-binding properties of KH motifs. RNA 9, 293-298 (2003
-
(2003)
RNA
, vol.9
, pp. 293-298
-
-
Ramos, A.1
Hollingworth, D.2
Pastore, A.3
-
25
-
-
17444384228
-
Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes
-
Darnell, J.C. et al. Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes. Genes Dev. 19, 903-918 (2005
-
(2005)
Genes Dev
, vol.19
, pp. 903-918
-
-
Darnell, J.C.1
-
26
-
-
0027377580
-
FMR-1 protein: Conserved RNP family domains and selective RNA binding
-
Ashley, C.T., Wilkinson, K.D., Reines, D. & Warren, S.T. FMR-1 protein: Conserved RNP family domains and selective RNA binding. Science 262, 563-566 (1993
-
(1993)
Science
, vol.262
, pp. 563-566
-
-
Ashley, C.T.1
Wilkinson, K.D.2
Reines, D.3
Warren, S.T.4
-
27
-
-
0030760613
-
The fragile X mental retardation protein is associated with poly(A)+ mRNA in actively translating polyribosomes
-
Corbin, F. et al. The fragile X mental retardation protein is associated with poly(A)+ mRNA in actively translating polyribosomes. Hum. Mol. Genet. 6, 1465-1472 (1997
-
(1997)
Hum. Mol. Genet
, vol.6
, pp. 1465-1472
-
-
Corbin, F.1
-
28
-
-
84865645908
-
Cytoplasmic RNA-binding proteins and the control of complex brain function
-
Darnell, J.C. & Richter, J.D. Cytoplasmic RNA-binding proteins and the control of complex brain function. Cold Spring Harb. Perspect. Biol. 4, a012344 (2012
-
(2012)
Cold Spring Harb. Perspect. Biol
, vol.4
-
-
Darnell, J.C.1
Richter, J.D.2
-
29
-
-
77953928753
-
HITS-CLIP: Panoramic views of protein-RNA regulation in living cells
-
Wiley Interdiscip
-
Darnell, R.B. HITS-CLIP: Panoramic views of protein-RNA regulation in living cells. Wiley Interdiscip. Rev. RNA 1, 266-286 (2010
-
(2010)
Rev. RNA
, vol.1
, pp. 266-286
-
-
Darnell, R.B.1
-
30
-
-
84863100938
-
Differences in AMPA and kainate receptor interactomes facilitate identification of AMPA receptor auxiliary subunit GSG1L
-
Shanks, N.F. et al. Differences in AMPA and kainate receptor interactomes facilitate identification of AMPA receptor auxiliary subunit GSG1L. Cell Rep. 1, 590-598 (2012
-
(2012)
Cell Rep
, vol.1
, pp. 590-598
-
-
Shanks, N.F.1
-
31
-
-
79952441030
-
Presynaptic translation: Stepping out of the postsynaptic shadow
-
Akins, M.R., Berk-Rauch, H.E. & Fallon, J.R. Presynaptic translation: Stepping out of the postsynaptic shadow. Front. Neural Circuits 3, 17 (2009
-
(2009)
Front. Neural Circuits
, vol.3
, pp. 17
-
-
Akins, M.R.1
Berk-Rauch, H.E.2
Fallon, J.R.3
-
32
-
-
34247116144
-
Presynaptic FMR1 genotype influences the degree of synaptic connectivity in a mosaic mouse model of fragile X syndrome
-
Hanson, J.E. & Madison, D.V. Presynaptic FMR1 genotype influences the degree of synaptic connectivity in a mosaic mouse model of fragile X syndrome. J. Neurosci. 27, 4014-4018 (2007
-
(2007)
J. Neurosci
, vol.27
, pp. 4014-4018
-
-
Hanson, J.E.1
Madison, D.V.2
-
33
-
-
79960955668
-
Abnormal presynaptic short-Term plasticity and information processing in a mouse model of fragile X syndrome
-
Deng, P.Y., Sojka, D. & Klyachko, V.A. Abnormal presynaptic short-Term plasticity and information processing in a mouse model of fragile X syndrome. J. Neurosci. 31, 10971-10982 (2011
-
(2011)
J. Neurosci
, vol.31
, pp. 10971-10982
-
-
Deng, P.Y.1
Sojka, D.2
Klyachko, V.A.3
-
34
-
-
65649083055
-
Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models
-
Zhang, J., Hou, L., Klann, E. & Nelson, D.L. Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models. J. Neurophysiol. 101, 2572-2580 (2009
-
(2009)
J. Neurophysiol
, vol.101
, pp. 2572-2580
-
-
Zhang, J.1
Hou, L.2
Klann, E.3
Nelson, D.L.4
-
35
-
-
53849100522
-
Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome
-
Gibson, J.R., Bartley, A.F., Hays, S.A. & Huber, K.M. Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome. J. Neurophysiol. 100, 2615-2626 (2008
-
(2008)
J. Neurophysiol
, vol.100
, pp. 2615-2626
-
-
Gibson, J.R.1
Bartley, A.F.2
Hays, S.A.3
Huber, K.M.4
-
36
-
-
77954858360
-
Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome
-
Suvrathan, A., Hoeffer, C.A., Wong, H., Klann, E. & Chattarji, S. Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome. Proc. Natl. Acad. Sci. USA 107, 11591-11596 (2010
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 11591-11596
-
-
Suvrathan, A.1
Hoeffer, C.A.2
Wong, H.3
Klann, E.4
Chattarji, S.5
-
37
-
-
68549091079
-
Requirement for protein synthesis at developing synapses
-
Sebeo, J. et al. Requirement for protein synthesis at developing synapses. J. Neurosci. 29, 9778-9793 (2009
-
(2009)
J. Neurosci
, vol.29
, pp. 9778-9793
-
-
Sebeo, J.1
-
38
-
-
33744966575
-
Local functions for FMRP in axon growth cone motility and activity-dependent regulation of filopodia and spine synapses
-
Antar, L.N., Li, C., Zhang, H., Carroll, R.C. & Bassell, G.J. Local functions for FMRP in axon growth cone motility and activity-dependent regulation of filopodia and spine synapses. Mol. Cell Neurosci. 32, 37-48 (2006
-
(2006)
Mol. Cell Neurosci
, vol.32
, pp. 37-48
-
-
Antar, L.N.1
Li, C.2
Zhang, H.3
Carroll, R.C.4
Bassell, G.J.5
-
39
-
-
0035864826
-
Evidence that fragile X mental retardation protein is a negative regulator of translation
-
Laggerbauer, B., Ostareck, D., Keidel, E.M., Ostareck-Lederer, A. & Fischer, U. Evidence that fragile X mental retardation protein is a negative regulator of translation. Hum. Mol. Genet. 10, 329-338 (2001
-
(2001)
Hum. Mol. Genet
, vol.10
, pp. 329-338
-
-
Laggerbauer, B.1
Ostareck, D.2
Keidel, E.M.3
Ostareck-Lederer, A.4
Fischer, U.5
-
40
-
-
0035368955
-
The fragile X mental retardation protein inhibits translation via interacting with mRNA
-
Li, Z. et al. The fragile X mental retardation protein inhibits translation via interacting with mRNA. Nucleic Acids Res. 29, 2276-2283 (2001
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 2276-2283
-
-
Li, Z.1
-
41
-
-
77956209418
-
Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome
-
Gross, C. et al. Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome. J. Neurosci. 30, 10624-10638 (2010
-
(2010)
J. Neurosci
, vol.30
, pp. 10624-10638
-
-
Gross, C.1
-
42
-
-
84860568814
-
Excess protein synthesis in FXS patient lymphoblastoid cells can be rescued with a p110beta-selective inhibitor
-
Gross, C. & Bassell, G.J. Excess protein synthesis in FXS patient lymphoblastoid cells can be rescued with a p110beta-selective inhibitor. Mol. Med. 18, 336-345 (2012
-
(2012)
Mol. Med
, vol.18
, pp. 336-345
-
-
Gross, C.1
Bassell, G.J.2
-
43
-
-
37049032616
-
Correction of fragile X syndrome in mice
-
Dölen, G. et al. Correction of fragile X syndrome in mice. Neuron 56, 955-962 (2007
-
(2007)
Neuron
, vol.56
, pp. 955-962
-
-
Dölen, G.1
-
44
-
-
84867736998
-
Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic and behavioral phenotypes in Fragile X syndrome mice
-
Bhattacharya, A. et al. Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic and behavioral phenotypes in Fragile X syndrome mice. Neuron 76, 325-337 (2012
-
(2012)
Neuron
, vol.76
, pp. 325-337
-
-
Bhattacharya, A.1
-
45
-
-
19044372933
-
Postadolescent changes in regional cerebral protein syn thesis: An in vivo study in the fmr1 null mouse
-
Qin, M., Kang, J., Burlin, T.V., Jiang, C. & Smith, C.B. Postadolescent changes in regional cerebral protein synthesis: An in vivo study in the FMR1 null mouse. J. Neurosci. 25, 5087-5095 (2005
-
(2005)
J. Neurosci
, vol.25
, pp. 5087-5095
-
-
Qin, M.1
Kang, J.2
Burlin, T.V.3
Jiang, C.4
Smith, C.B.5
-
46
-
-
78449259794
-
Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome
-
Osterweil, E.K., Krueger, D.D., Reinhold, K. & Bear, M.F. Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome. J. Neurosci. 30, 15616-15627 (2010
-
(2010)
J. Neurosci
, vol.30
, pp. 15616-15627
-
-
Osterweil, E.K.1
Krueger, D.D.2
Reinhold, K.3
Bear, M.F.4
-
47
-
-
0035977134
-
Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function
-
Zhang, Y.Q. et al. Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. Cell 107, 591-603 (2001
-
(2001)
Cell
, vol.107
, pp. 591-603
-
-
Zhang, Y.Q.1
-
48
-
-
0037423293
-
The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses
-
Zalfa, F. et al. The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses. Cell 112, 317-327 (2003
-
(2003)
Cell
, vol.112
, pp. 317-327
-
-
Zalfa, F.1
-
49
-
-
84863333644
-
Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model
-
Goebel-Goody, S.M. et al. Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model. Genes Brain Behav. 11, 586-600 (2012
-
(2012)
Genes Brain Behav
, vol.11
, pp. 586-600
-
-
Goebel-Goody, S.M.1
-
50
-
-
77955393170
-
Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b
-
Strumbos, J.G., Brown, M.R., Kronengold, J., Polley, D.B. & Kaczmarek, L.K. Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b. J. Neurosci. 30, 10263-10271 (2010
-
(2010)
J. Neurosci
, vol.30
, pp. 10263-10271
-
-
Strumbos, J.G.1
Brown, M.R.2
Kronengold, J.3
Polley, D.B.4
Kaczmarek, L.K.5
-
51
-
-
84155177066
-
Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein
-
Lee, H.Y. et al. Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein. Neuron 72, 630-642 (2011
-
(2011)
Neuron
, vol.72
, pp. 630-642
-
-
Lee, H.Y.1
-
52
-
-
74949102875
-
Dysregulation of mTOR signaling in fragile X syndrome
-
Sharma, A. et al. Dysregulation of mTOR signaling in fragile X syndrome. J. Neurosci. 30, 694-702 (2010
-
(2010)
J. Neurosci
, vol.30
, pp. 694-702
-
-
Sharma, A.1
-
53
-
-
70350022707
-
Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities
-
Schütt, J., Falley, K., Richter, D., Kreienkamp, H.J. & Kindler, S. Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities. J. Biol. Chem. 284, 25479-25487 (2009
-
(2009)
J. Biol. Chem
, vol.284
, pp. 25479-25487
-
-
Schütt, J.1
Falley, K.2
Richter, D.3
Kreienkamp, H.J.4
Kindler, S.5
-
54
-
-
84859420878
-
Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome
-
Hoeffer, C.A. et al. Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome. Genes Brain Behav. 11, 332-341 (2012
-
(2012)
Genes Brain Behav
, vol.11
, pp. 332-341
-
-
Hoeffer, C.A.1
-
55
-
-
79952301339
-
Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome
-
Krueger, D.D., Osterweil, E.K., Chen, S.P., Tye, L.D. & Bear, M.F. Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome. Proc. Natl. Acad. Sci. USA 108, 2587-2592 (2011
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 2587-2592
-
-
Krueger, D.D.1
Osterweil, E.K.2
Chen, S.P.3
Tye, L.D.4
Bear, M.F.5
-
56
-
-
3042647610
-
The mGluR theory of fragile X mental retardation
-
Bear, M.F., Huber, K.M. & Warren, S.T. The mGluR theory of fragile X mental retardation. Trends Neurosci. 27, 370-377 (2004
-
(2004)
Trends Neurosci
, vol.27
, pp. 370-377
-
-
Bear, M.F.1
Huber, K.M.2
Warren, S.T.3
-
57
-
-
84859628864
-
Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice
-
Michalon, A. et al. Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice. Neuron 74, 49-56 (2012
-
(2012)
Neuron
, vol.74
, pp. 49-56
-
-
Michalon, A.1
-
58
-
-
65949096495
-
A pilot open label, single dose trial of fenobam in adults with fragile X syndrome
-
Berry-Kravis, E. et al. A pilot open label, single dose trial of fenobam in adults with fragile X syndrome. J. Med. Genet. 46, 266-271 (2009
-
(2009)
J. Med. Genet
, vol.46
, pp. 266-271
-
-
Berry-Kravis, E.1
-
59
-
-
9944229967
-
Biochemical mechanisms for translational regulation in synaptic plasticity
-
Klann, E. & Dever, T.E. Biochemical mechanisms for translational regulation in synaptic plasticity. Nat. Rev. Neurosci. 5, 931-942 (2004
-
(2004)
Nat. Rev. Neurosci
, vol.5
, pp. 931-942
-
-
Klann, E.1
Dever, T.E.2
-
60
-
-
75749114797
-
Mtor signaling: At the crossroads of plasticity memory and disease
-
Hoeffer, C.A. & Klann, E. mTOR signaling: At the crossroads of plasticity, memory and disease. Trends Neurosci. 33, 67-75 (2010
-
(2010)
Trends Neurosci
, vol.33
, pp. 67-75
-
-
Hoeffer, C.A.1
Klann, E.2
-
61
-
-
54949144402
-
The autistic neuron: Troubled translation?
-
Kelleher, R.J.r. & Bear, M.F. The autistic neuron: Troubled translation? Cell 135, 401-406 (2008
-
(2008)
Cell
, vol.135
, pp. 401-406
-
-
Kelleher Jr., R.1
Bear, M.F.2
-
62
-
-
41449117763
-
The cyclic AMP cascade is altered in the fragile X nervous system
-
Kelley, D.J. et al. The cyclic AMP cascade is altered in the fragile X nervous system. PLoS ONE 2, e931 (2007
-
(2007)
PLoS ONE
, vol.2
-
-
Kelley, D.J.1
-
63
-
-
0027498425
-
Demonstration of abnormal cyclic AMP production in platelets from patients with fragile X syndrome
-
Berry-Kravis, E. & Sklena, P. Demonstration of abnormal cyclic AMP production in platelets from patients with fragile X syndrome. Am. J. Med. Genet. 45, 81-87 (1993
-
(1993)
Am. J. Med. Genet
, vol.45
, pp. 81-87
-
-
Berry-Kravis, E.1
Sklena, P.2
-
64
-
-
0036198673
-
Reduced cortical synaptic plasticity and GluR1 expression associated with fragile X mental retardation protein deficiency
-
Li, J., Pelletier, M.R., Perez Velazquez, J.L. & Carlen, P.L. Reduced cortical synaptic plasticity and GluR1 expression associated with fragile X mental retardation protein deficiency. Mol. Cell Neurosci. 19, 138-151 (2002
-
(2002)
Mol. Cell Neurosci
, vol.19
, pp. 138-151
-
-
Li, J.1
Pelletier, M.R.2
Perez Velazquez, J.L.3
Carlen, P.L.4
-
65
-
-
20544447033
-
Rho gtpases dendritic structure and mental retardation
-
Newey, S.E., Velamoor, V., Govek, E.E. & Van Aelst, L. Rho GTPases, dendritic structure and mental retardation. J. Neurobiol. 64, 58-74 (2005
-
(2005)
J. Neurobiol
, vol.64
, pp. 58-74
-
-
Newey, S.E.1
Velamoor, V.2
Govek, E.E.3
Van Aelst, L.4
-
66
-
-
33645217296
-
SynGAP regulates synaptic strength and mitogen-Activated protein kinases in cultured neurons
-
Rumbaugh, G., Adams, J.P., Kim, J.H. & Huganir, R.L. SynGAP regulates synaptic strength and mitogen-Activated protein kinases in cultured neurons. Proc. Natl. Acad. Sci. USA 103, 4344-4351 (2006
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 4344-4351
-
-
Rumbaugh, G.1
Adams, J.P.2
Kim, J.H.3
Huganir, R.L.4
-
67
-
-
77954657070
-
Functional impact of global rare copy number variation in autism spectrum disorders
-
Pinto, D. et al. Functional impact of global rare copy number variation in autism spectrum disorders. Nature 466, 368-372 (2010
-
(2010)
Nature
, vol.466
, pp. 368-372
-
-
Pinto, D.1
-
68
-
-
0034685813
-
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-Term depression
-
Huber, K.M., Kayser, M.S. & Bear, M.F. Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-Term depression. Science 288, 1254-1257 (2000
-
(2000)
Science
, vol.288
, pp. 1254-1257
-
-
Huber, K.M.1
Kayser, M.S.2
Bear, M.F.3
-
69
-
-
0037188502
-
Altered synaptic plasticity in a mouse model of fragile X mental retardation
-
Huber, K.M., Gallagher, S.M., Warren, S.T. & Bear, M.F. Altered synaptic plasticity in a mouse model of fragile X mental retardation. Proc. Natl. Acad. Sci. USA 99, 7746-7750 (2002
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 7746-7750
-
-
Huber, K.M.1
Gallagher, S.M.2
Warren, S.T.3
Bear, M.F.4
-
70
-
-
20044388322
-
Pharmacological rescue of synaptic plasticity, courtship behavior and mushroom body defects in a Drosophila model of fragile X syndrome
-
McBride, S.M. et al. Pharmacological rescue of synaptic plasticity, courtship behavior and mushroom body defects in a Drosophila model of fragile X syndrome. Neuron 45, 753-764 (2005
-
(2005)
Neuron
, vol.45
, pp. 753-764
-
-
McBride, S.M.1
-
71
-
-
14744291567
-
Decreased GABA(A) receptor expression in the seizure-prone fragile X mouse
-
El Idrissi, A. et al. Decreased GABA(A) receptor expression in the seizure-prone fragile X mouse. Neurosci. Lett. 377, 141-146 (2005
-
(2005)
Neurosci. Lett
, vol.377
, pp. 141-146
-
-
El Idrissi, A.1
-
72
-
-
33750726094
-
Decreased expression of the GABAA receptor in fragile X syndrome
-
D'Hulst, C. et al. Decreased expression of the GABAA receptor in fragile X syndrome. Brain Res. 1121, 238-245 (2006
-
(2006)
Brain Res
, vol.1121
, pp. 238-245
-
-
D'Hulst, C.1
-
73
-
-
77954143021
-
Early developmental alterations in GABAergic protein expression in fragile X knockout mice
-
Adusei, D.C., Pacey, L.K., Chen, D. & Hampson, D.R. Early developmental alterations in GABAergic protein expression in fragile X knockout mice. Neuropharmacology 59, 167-171 (2010
-
(2010)
Neuropharmacology
, vol.59
, pp. 167-171
-
-
Adusei, D.C.1
Pacey, L.K.2
Chen, D.3
Hampson, D.R.4
-
74
-
-
41049102573
-
Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila
-
Chang, S. et al. Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Nat. Chem. Biol. 4, 256-263 (2008
-
(2008)
Nat. Chem. Biol
, vol.4
, pp. 256-263
-
-
Chang, S.1
-
75
-
-
84856578911
-
Pharmacological treatment of fragile X syndrome with GABAergic drugs in a knockout mouse model
-
Heulens, I., D'Hulst, C., Van Dam, D., De Deyn, P.P. & Kooy, R.F. Pharmacological treatment of fragile X syndrome with GABAergic drugs in a knockout mouse model. Behav. Brain Res. 229, 244-249 (2012
-
(2012)
Behav. Brain Res
, vol.229
, pp. 244-249
-
-
Heulens, I.1
D'Hulst, C.2
Van Dam, D.3
De Deyn, P.P.4
Kooy, R.F.5
-
76
-
-
84866615813
-
Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABA(B) receptors with arbaclofen
-
152ra128
-
Henderson, C. et al. Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABA(B) receptors with arbaclofen. Sci. Transl. Med. 4, 152ra128 (2012
-
(2012)
Sci. Transl. Med
, vol.4
-
-
Henderson, C.1
-
77
-
-
84866628742
-
Effects of STX209 (arbaclofen) on neurobehavioral function in children and adults with fragile X syndrome: A randomized, controlled, phase 2 trial
-
152ra127
-
Berry-Kravis, E.M. et al. Effects of STX209 (arbaclofen) on neurobehavioral function in children and adults with fragile X syndrome: A randomized, controlled, phase 2 trial. Sci. Transl. Med. 4, 152ra127 (2012
-
(2012)
Sci. Transl. Med
, vol.4
-
-
Berry-Kravis, E.M.1
-
78
-
-
58149485508
-
Making synaptic plasticity and memory last: Mechanisms of translational regulation
-
Richter, J.D. & Klann, E. Making synaptic plasticity and memory last: Mechanisms of translational regulation. Genes Dev. 23, 1-11 (2009
-
(2009)
Genes Dev
, vol.23
, pp. 1-11
-
-
Richter, J.D.1
Klann, E.2
-
79
-
-
4043055356
-
Synaptic plasticity and translation initiation
-
Klann, E., Antion, M.D., Banko, J.L. & Hou, L. Synaptic plasticity and translation initiation. Learn. Mem. 11, 365-372 (2004
-
(2004)
Learn. Mem
, vol.11
, pp. 365-372
-
-
Klann, E.1
Antion, M.D.2
Banko, J.L.3
Hou, L.4
-
80
-
-
58149469090
-
Translational control of long-lasting synaptic plasticity and memory
-
Costa-Mattioli, M., Sossin, W.S., Klann, E. & Sonenberg, N. Translational control of long-lasting synaptic plasticity and memory. Neuron 61, 10-26 (2009
-
(2009)
Neuron
, vol.61
, pp. 10-26
-
-
Costa-Mattioli, M.1
Sossin, W.S.2
Klann, E.3
Sonenberg, N.4
-
81
-
-
84862777306
-
Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome
-
Ronesi, J.A. et al. Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome. Nat. Neurosci. 15, 431-440 (2012
-
(2012)
Nat. Neurosci
, vol.15
, pp. 431-440
-
-
Ronesi, J.A.1
-
82
-
-
0032932198
-
P70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signaling complex
-
Romanelli, A., Martin, K.A., Toker, A. & Blenis, J. p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signaling complex. Mol. Cell Biol. 19, 2921-2928 (1999
-
(1999)
Mol. Cell Biol
, vol.19
, pp. 2921-2928
-
-
Romanelli, A.1
Martin, K.A.2
Toker, A.3
Blenis, J.4
-
83
-
-
84872716739
-
Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome
-
Osterweil, E.K. et al. Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome. Neuron 77, 243-250 (2013
-
(2013)
Neuron
, vol.77
, pp. 243-250
-
-
Osterweil, E.K.1
-
84
-
-
27744588780
-
Tuberous sclerosis: A GAP at the crossroads of multiple signaling pathways
-
Kwiatkowski, D.J. & Manning, B.D. Tuberous sclerosis: A GAP at the crossroads of multiple signaling pathways. Hum. Mol. Genet. 14, 251-258 (2005
-
(2005)
Hum. Mol. Genet
, vol.14
, pp. 251-258
-
-
Kwiatkowski, D.J.1
Manning, B.D.2
-
85
-
-
82555196668
-
Mutations causing syndromic autism define an axis of synaptic pathophysiology
-
Auerbach, B.D., Osterweil, E.K. & Bear, M.F. Mutations causing syndromic autism define an axis of synaptic pathophysiology. Nature 480, 63-68 (2011
-
(2011)
Nature
, vol.480
, pp. 63-68
-
-
Auerbach, B.D.1
Osterweil, E.K.2
Bear, M.F.3
-
86
-
-
40649104735
-
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis
-
Ozcan, U. et al. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol. Cell 29, 541-551 (2008
-
(2008)
Mol. Cell
, vol.29
, pp. 541-551
-
-
Ozcan, U.1
-
87
-
-
77956650465
-
GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of fragile X syndrome and autism
-
Mines, M.A., Yuskaitis, C.J., King, M.K., Beurel, E. & Jope, R.S. GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of fragile X syndrome and autism. PLoS ONE 5, e9706 (2010
-
(2010)
PLoS ONE
, vol.5
-
-
Mines, M.A.1
Yuskaitis, C.J.2
King, M.K.3
Beurel, E.4
Jope, R.S.5
-
88
-
-
84862908964
-
Inhibition of GSK3beta improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome
-
Guo, W. et al. Inhibition of GSK3beta improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome. Hum. Mol. Genet. 21, 681-691 (2012
-
(2012)
Hum. Mol. Genet
, vol.21
, pp. 681-691
-
-
Guo, W.1
-
89
-
-
38349029199
-
Homer interactions are necessary for metabotropic glutamate receptor-induced long-Term depression and translational activation
-
Ronesi, J.A. & Huber, K.M. Homer interactions are necessary for metabotropic glutamate receptor-induced long-Term depression and translational activation. J. Neurosci. 28, 543-547 (2008
-
(2008)
J. Neurosci
, vol.28
, pp. 543-547
-
-
Ronesi, J.A.1
Huber, K.M.2
-
90
-
-
70450208984
-
Deregulation of EIF4E: A novel mechanism for autism
-
Neves-Pereira, M. et al. Deregulation of EIF4E: A novel mechanism for autism. J. Med. Genet. 46, 759-765 (2009
-
(2009)
J. Med. Genet
, vol.46
, pp. 759-765
-
-
Neves-Pereira, M.1
-
91
-
-
51549108502
-
The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP
-
Napoli, I. et al. The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell 134, 1042-1054 (2008
-
(2008)
Cell
, vol.134
, pp. 1042-1054
-
-
Napoli, I.1
-
92
-
-
84872617263
-
Exaggerated translation causes synaptic and behavioural aberrations associated with autism
-
Santini, E. et al. Exaggerated translation causes synaptic and behavioural aberrations associated with autism. Nature 493, 411-415 (2013
-
(2013)
Nature
, vol.493
, pp. 411-415
-
-
Santini, E.1
-
93
-
-
62149089881
-
Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model
-
Bilousova, T.V. et al. Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model. J. Med. Genet. 46, 94-102 (2009
-
(2009)
J. Med. Genet
, vol.46
, pp. 94-102
-
-
Bilousova, T.V.1
-
94
-
-
80052289615
-
Neural circuit architecture defects in a Drosophila model of Fragile X syndrome are alleviated by minocycline treatment and genetic removal of matrix metalloproteinase
-
Siller, S.S. & Broadie, K. Neural circuit architecture defects in a Drosophila model of Fragile X syndrome are alleviated by minocycline treatment and genetic removal of matrix metalloproteinase. Dis. Model Mech. 4, 673-685 (2011
-
(2011)
Dis. Model Mech
, vol.4
, pp. 673-685
-
-
Siller, S.S.1
Broadie, K.2
-
95
-
-
57549088119
-
Minocycline and neurodegenerative diseases
-
Kim, H.S. & Suh, Y.H. Minocycline and neurodegenerative diseases. Behav. Brain Res. 196, 168-179 (2009
-
(2009)
Behav. Brain Res
, vol.196
, pp. 168-179
-
-
Kim, H.S.1
Suh, Y.H.2
-
96
-
-
49249133699
-
Features of 80S mammalian ribosome and its subunits
-
Budkevich, T.V., El'skaya, A.V. & Nierhaus, K.H. Features of 80S mammalian ribosome and its subunits. Nucleic Acids Res. 36, 4736-4744 (2008
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 4736-4744
-
-
Budkevich, T.V.1
El'skaya, A.V.2
Nierhaus, K.H.3
-
97
-
-
77957678816
-
Open-label add-on treatment trial of minocycline in fragile X syndrome
-
Paribello, C. et al. Open-label add-on treatment trial of minocycline in fragile X syndrome. BMC Neurol. 10, 91 (2010
-
(2010)
BMC Neurol
, vol.10
, pp. 91
-
-
Paribello, C.1
|