메뉴 건너뛰기




Volumn 131, Issue , 2015, Pages 73-118

Sensory TRP channels: The key transducers of nociception and pain

Author keywords

TRP channel Nociception TRPV1 TRPV2 TRPV3 TRPV4 TRPM3 TRPM8 TRPA1 Pain

Indexed keywords

ION CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL M3; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST; VANILLOID RECEPTOR 2; VANILLOID RECEPTOR 3; VANILLOID RECEPTOR 4;

EID: 84924581659     PISSN: 18771173     EISSN: 18780814     Source Type: Book Series    
DOI: 10.1016/bs.pmbts.2015.01.002     Document Type: Chapter
Times cited : (118)

References (270)
  • 1
    • 47049130315 scopus 로고    scopus 로고
    • The Kyoto protocol of IASP basic pain terminology
    • J.D. Loeser, and R.D. Treede The Kyoto protocol of IASP basic pain terminology Pain 137 2008 473 477
    • (2008) Pain , vol.137 , pp. 473-477
    • Loeser, J.D.1    Treede, R.D.2
  • 3
    • 77956272001 scopus 로고    scopus 로고
    • International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family
    • L.J. Wu, T.B. Sweet, and D.E. Clapham International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family Pharmacol Rev 62 2010 381 404
    • (2010) Pharmacol Rev , vol.62 , pp. 381-404
    • Wu, L.J.1    Sweet, T.B.2    Clapham, D.E.3
  • 4
    • 0347504835 scopus 로고    scopus 로고
    • TRP channels as cellular sensors
    • D.E. Clapham TRP channels as cellular sensors Nature 426 2003 517 524
    • (2003) Nature , vol.426 , pp. 517-524
    • Clapham, D.E.1
  • 5
    • 0035838673 scopus 로고    scopus 로고
    • Physiology, phylogeny, and functions of the TRP superfamily of cation channels
    • C. Montell Physiology, phylogeny, and functions of the TRP superfamily of cation channels Sci STKE 2001 2001 re1
    • (2001) Sci STKE , vol.2001 , pp. re1
    • Montell, C.1
  • 6
    • 0014683485 scopus 로고
    • Abnormal electroretinogram from a Drosophila mutant
    • D.J. Cosens, and A. Manning Abnormal electroretinogram from a Drosophila mutant Nature 224 1969 285 287
    • (1969) Nature , vol.224 , pp. 285-287
    • Cosens, D.J.1    Manning, A.2
  • 7
    • 78649340763 scopus 로고    scopus 로고
    • The history of the Drosophila TRP channel: The birth of a new channel superfamily
    • B. Minke The history of the Drosophila TRP channel: the birth of a new channel superfamily J Neurogenet 24 2010 216 233
    • (2010) J Neurogenet , vol.24 , pp. 216-233
    • Minke, B.1
  • 8
    • 84889594608 scopus 로고    scopus 로고
    • TRPV1 structures in distinct conformations reveal activation mechanisms
    • E. Cao, M. Liao, Y. Cheng, and D. Julius TRPV1 structures in distinct conformations reveal activation mechanisms Nature 504 2013 113 118
    • (2013) Nature , vol.504 , pp. 113-118
    • Cao, E.1    Liao, M.2    Cheng, Y.3    Julius, D.4
  • 9
    • 84889607320 scopus 로고    scopus 로고
    • Structure of the TRPV1 ion channel determined by electron cryo-microscopy
    • M. Liao, E. Cao, D. Julius, and Y. Cheng Structure of the TRPV1 ion channel determined by electron cryo-microscopy Nature 504 2013 107 112
    • (2013) Nature , vol.504 , pp. 107-112
    • Liao, M.1    Cao, E.2    Julius, D.3    Cheng, Y.4
  • 11
    • 26444457870 scopus 로고    scopus 로고
    • Homo- and heteromeric assembly of TRP channel subunits
    • M. Schaefer Homo- and heteromeric assembly of TRP channel subunits Pflugers Arch 451 2005 35 42
    • (2005) Pflugers Arch , vol.451 , pp. 35-42
    • Schaefer, M.1
  • 12
    • 51349083674 scopus 로고    scopus 로고
    • Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor i
    • P. Valente, N. García-Sanz, and A. Gomis Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I FASEB J 22 2008 3298 3309
    • (2008) FASEB J , vol.22 , pp. 3298-3309
    • Valente, P.1    García-Sanz, N.2    Gomis, A.3
  • 13
    • 36649016621 scopus 로고    scopus 로고
    • Voltage is a partial activator of rat thermosensitive TRP channels
    • J.A. Matta, and G.P. Ahern Voltage is a partial activator of rat thermosensitive TRP channels J Physiol 585 2007 469 482
    • (2007) J Physiol , vol.585 , pp. 469-482
    • Matta, J.A.1    Ahern, G.P.2
  • 14
    • 78650914392 scopus 로고    scopus 로고
    • Regulation of nociceptive transmission at the periphery via TRPA1-TRPV1 interactions
    • A.N. Akopian Regulation of nociceptive transmission at the periphery via TRPA1-TRPV1 interactions Curr Pharm Biotechnol 12 2011 89 94
    • (2011) Curr Pharm Biotechnol , vol.12 , pp. 89-94
    • Akopian, A.N.1
  • 15
    • 33847394506 scopus 로고    scopus 로고
    • Thermosensitive TRPV channel subunits coassemble into heteromeric channels with intermediate conductance and gating properties
    • W. Cheng, F. Yang, C.L. Takanishi, and J. Zheng Thermosensitive TRPV channel subunits coassemble into heteromeric channels with intermediate conductance and gating properties J Gen Physiol 129 2007 191 207
    • (2007) J Gen Physiol , vol.129 , pp. 191-207
    • Cheng, W.1    Yang, F.2    Takanishi, C.L.3    Zheng, J.4
  • 16
    • 84911995832 scopus 로고    scopus 로고
    • Direct evidence for functional TRPV1/TRPA1 heteromers
    • M.J. Fischer, D. Balasuriya, and P. Jeggle Direct evidence for functional TRPV1/TRPA1 heteromers Pflugers Arch 466 2014 2229 2241
    • (2014) Pflugers Arch , vol.466 , pp. 2229-2241
    • Fischer, M.J.1    Balasuriya, D.2    Jeggle, P.3
  • 18
    • 72149113587 scopus 로고    scopus 로고
    • The transient receptor potential (TRP) channels TRPP2 and TRPC1 form a heterotetramer with a 2:2 stoichiometry and an alternating subunit arrangement
    • T. Kobori, G.D. Smith, R. Sandford, and J.M. Edwardson The transient receptor potential (TRP) channels TRPP2 and TRPC1 form a heterotetramer with a 2:2 stoichiometry and an alternating subunit arrangement J Biol Chem 284 2009 35507 35513
    • (2009) J Biol Chem , vol.284 , pp. 35507-35513
    • Kobori, T.1    Smith, G.D.2    Sandford, R.3    Edwardson, J.M.4
  • 20
    • 84885827972 scopus 로고    scopus 로고
    • TRP channels and pain
    • D. Julius TRP channels and pain Annu Rev Cell Dev Biol 29 2013 355 384
    • (2013) Annu Rev Cell Dev Biol , vol.29 , pp. 355-384
    • Julius, D.1
  • 21
    • 66749156637 scopus 로고    scopus 로고
    • Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli
    • D.J. Cavanaugh, H. Lee, and L. Lo Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli Proc Natl Acad Sci USA 106 2009 9075 9080
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 9075-9080
    • Cavanaugh, D.J.1    Lee, H.2    Lo, L.3
  • 22
    • 20444407993 scopus 로고    scopus 로고
    • Expression of the vanilloid receptor TRPV1 in rat dorsal root ganglion neurons supports different roles of the receptor in visceral and cutaneous afferents
    • S.J. Hwang, J.M. Oh, and J.G. Valtschanoff Expression of the vanilloid receptor TRPV1 in rat dorsal root ganglion neurons supports different roles of the receptor in visceral and cutaneous afferents Brain Res 1047 2005 261 266
    • (2005) Brain Res , vol.1047 , pp. 261-266
    • Hwang, S.J.1    Oh, J.M.2    Valtschanoff, J.G.3
  • 23
    • 28844471303 scopus 로고    scopus 로고
    • Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors
    • K. Kobayashi, T. Fukuoka, and K. Obata Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors J Comp Neurol 493 2005 596 606
    • (2005) J Comp Neurol , vol.493 , pp. 596-606
    • Kobayashi, K.1    Fukuoka, T.2    Obata, K.3
  • 24
    • 0032169804 scopus 로고    scopus 로고
    • The cloned capsaicin receptor integrates multiple pain-producing stimuli
    • M. Tominaga, M.J. Caterina, and A.B. Malmberg The cloned capsaicin receptor integrates multiple pain-producing stimuli Neuron 21 1998 531 543
    • (1998) Neuron , vol.21 , pp. 531-543
    • Tominaga, M.1    Caterina, M.J.2    Malmberg, A.B.3
  • 25
    • 58749096723 scopus 로고    scopus 로고
    • The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund's adjuvant
    • L. Yu, F. Yang, and H. Luo The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund's adjuvant Mol Pain 4 2008 61
    • (2008) Mol Pain , vol.4 , pp. 61
    • Yu, L.1    Yang, F.2    Luo, H.3
  • 26
    • 66349132214 scopus 로고    scopus 로고
    • Parvalbumin and TRPV1 receptor expression in dorsal root ganglion neurons after acute peripheral inflammation
    • G. Zacharova, and J. Palecek Parvalbumin and TRPV1 receptor expression in dorsal root ganglion neurons after acute peripheral inflammation Physiol Res 58 2009 305 309
    • (2009) Physiol Res , vol.58 , pp. 305-309
    • Zacharova, G.1    Palecek, J.2
  • 27
    • 84907183896 scopus 로고    scopus 로고
    • TRPV1: A potential drug target for treating various diseases
    • R. Brito, S. Sheth, D. Mukherjea, L.P. Rybak, and V. Ramkumar TRPV1: a potential drug target for treating various diseases Cells 3 2014 517 545
    • (2014) Cells , vol.3 , pp. 517-545
    • Brito, R.1    Sheth, S.2    Mukherjea, D.3    Rybak, L.P.4    Ramkumar, V.5
  • 28
    • 70349272715 scopus 로고    scopus 로고
    • Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesia
    • J.A. Jeffry, S.Q. Yu, P. Sikand, A. Parihar, M.S. Evans, and L.S. Premkumar Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesia PLoS One 4 2009 e7021
    • (2009) PLoS One , vol.4 , pp. e7021
    • Jeffry, J.A.1    Yu, S.Q.2    Sikand, P.3    Parihar, A.4    Evans, M.S.5    Premkumar, L.S.6
  • 29
    • 67649612716 scopus 로고    scopus 로고
    • The role of the TRPV1 endogenous agonist N-Oleoyldopamine in modulation of nociceptive signaling at the spinal cord level
    • D. Spicarova, and J. Palecek The role of the TRPV1 endogenous agonist N-Oleoyldopamine in modulation of nociceptive signaling at the spinal cord level J Neurophysiol 102 2009 234 243
    • (2009) J Neurophysiol , vol.102 , pp. 234-243
    • Spicarova, D.1    Palecek, J.2
  • 30
    • 45849132372 scopus 로고    scopus 로고
    • The role of spinal cord vanilloid (TRPV1) receptors in pain modulation
    • D. Spicarova, and J. Palecek The role of spinal cord vanilloid (TRPV1) receptors in pain modulation Physiol Res 57 Suppl 3 2008 S69 S77
    • (2008) Physiol Res , vol.57 , pp. S69-S77
    • Spicarova, D.1    Palecek, J.2
  • 31
    • 84897589790 scopus 로고    scopus 로고
    • Update on the role of spinal cord TRPV1 receptors in pain modulation
    • D. Spicarova, V. Nerandzic, and J. Palecek Update on the role of spinal cord TRPV1 receptors in pain modulation Physiol Res 63 Suppl 1 2014 S225 S236
    • (2014) Physiol Res , vol.63 , pp. S225-S236
    • Spicarova, D.1    Nerandzic, V.2    Palecek, J.3
  • 32
    • 79960413942 scopus 로고    scopus 로고
    • Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons
    • D.J. Cavanaugh, A.T. Chesler, J.M. Braz, N.M. Shah, D. Julius, and A.I. Basbaum Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons J Neurosci 31 2011 10119 10127
    • (2011) J Neurosci , vol.31 , pp. 10119-10127
    • Cavanaugh, D.J.1    Chesler, A.T.2    Braz, J.M.3    Shah, N.M.4    Julius, D.5    Basbaum, A.I.6
  • 34
    • 84872691932 scopus 로고    scopus 로고
    • Gonadal ERalpha/beta, AR and TRPV1 gene expression: Modulation by pain and morphine treatment in male and female rats
    • S. Vodo, D. Arcelli, and P. Fiorenzani Gonadal ERalpha/beta, AR and TRPV1 gene expression: modulation by pain and morphine treatment in male and female rats Physiol Behav 110-111 2013 80 86
    • (2013) Physiol Behav , vol.110-111 , pp. 80-86
    • Vodo, S.1    Arcelli, D.2    Fiorenzani, P.3
  • 35
    • 0035958884 scopus 로고    scopus 로고
    • Analysis of the native quaternary structure of vanilloid receptor 1
    • N. Kedei, T. Szabo, and J.D. Lile Analysis of the native quaternary structure of vanilloid receptor 1 J Biol Chem 276 2001 28613 28619
    • (2001) J Biol Chem , vol.276 , pp. 28613-28619
    • Kedei, N.1    Szabo, T.2    Lile, J.D.3
  • 36
    • 34250190946 scopus 로고    scopus 로고
    • The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity
    • P.V. Lishko, E. Procko, X. Jin, C.B. Phelps, and R. Gaudet The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity Neuron 54 2007 905 918
    • (2007) Neuron , vol.54 , pp. 905-918
    • Lishko, P.V.1    Procko, E.2    Jin, X.3    Phelps, C.B.4    Gaudet, R.5
  • 38
    • 84889578787 scopus 로고    scopus 로고
    • Structural biology: Ion channel seen by electron microscopy
    • R. Henderson Structural biology: ion channel seen by electron microscopy Nature 504 2013 93 94
    • (2013) Nature , vol.504 , pp. 93-94
    • Henderson, R.1
  • 39
    • 84874229704 scopus 로고    scopus 로고
    • TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids
    • E. Cao, F. Cordero-Morales Julio, B. Liu, F. Qin, and D. Julius TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids Neuron 77 2013 667 679
    • (2013) Neuron , vol.77 , pp. 667-679
    • Cao, E.1    Cordero-Morales Julio, F.2    Liu, B.3    Qin, F.4    Julius, D.5
  • 40
    • 0034608878 scopus 로고    scopus 로고
    • Acid potentiation of the capsaicin receptor determined by a key extracellular site
    • S.E. Jordt, M. Tominaga, and D. Julius Acid potentiation of the capsaicin receptor determined by a key extracellular site Proc Natl Acad Sci USA 97 2000 8134 8139
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 8134-8139
    • Jordt, S.E.1    Tominaga, M.2    Julius, D.3
  • 41
    • 58149373549 scopus 로고    scopus 로고
    • TRPV1 is activated by both acidic and basic pH
    • A. Dhaka, V. Uzzell, and A.E. Dubin TRPV1 is activated by both acidic and basic pH J Neurosci 29 2009 153 158
    • (2009) J Neurosci , vol.29 , pp. 153-158
    • Dhaka, A.1    Uzzell, V.2    Dubin, A.E.3
  • 42
    • 0037062411 scopus 로고    scopus 로고
    • An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors
    • S.M. Huang, T. Bisogno, and M. Trevisani An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors Proc Natl Acad Sci USA 99 2002 8400 8405
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8400-8405
    • Huang, S.M.1    Bisogno, T.2    Trevisani, M.3
  • 43
    • 0004906771 scopus 로고    scopus 로고
    • Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances
    • S.W. Hwang, H. Cho, and J. Kwak Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances Proc Natl Acad Sci USA 97 2000 6155 6160
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6155-6160
    • Hwang, S.W.1    Cho, H.2    Kwak, J.3
  • 44
    • 0033614984 scopus 로고    scopus 로고
    • Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
    • P.M. Zygmunt, J. Petersson, and D.A. Andersson Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide Nature 400 1999 452 457
    • (1999) Nature , vol.400 , pp. 452-457
    • Zygmunt, P.M.1    Petersson, J.2    Andersson, D.A.3
  • 45
    • 83655161366 scopus 로고    scopus 로고
    • Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site
    • A. Nieto-Posadas, G. Picazo-Juarez, and I. Llorente Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site Nat Chem Biol 8 2012 78 85
    • (2012) Nat Chem Biol , vol.8 , pp. 78-85
    • Nieto-Posadas, A.1    Picazo-Juarez, G.2    Llorente, I.3
  • 46
    • 66849104240 scopus 로고    scopus 로고
    • Pharmacology of vanilloid transient receptor potential cation channels
    • J. Vriens, G. Appendino, and B. Nilius Pharmacology of vanilloid transient receptor potential cation channels Mol Pharmacol 75 2009 1262 1279
    • (2009) Mol Pharmacol , vol.75 , pp. 1262-1279
    • Vriens, J.1    Appendino, G.2    Nilius, B.3
  • 47
    • 84905029508 scopus 로고    scopus 로고
    • Redox regulation of transient receptor potential channels
    • D. Kozai, N. Ogawa, and Y. Mori Redox regulation of transient receptor potential channels Antioxid Redox Signal 21 2014 971 986
    • (2014) Antioxid Redox Signal , vol.21 , pp. 971-986
    • Kozai, D.1    Ogawa, N.2    Mori, Y.3
  • 48
    • 0032881344 scopus 로고    scopus 로고
    • Resiniferatoxin-type phorboid vanilloids display capsaicin-like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1
    • A. Szallasi, T. Szabo, and T. Biro Resiniferatoxin-type phorboid vanilloids display capsaicin-like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1 Br J Pharmacol 128 1999 428 434
    • (1999) Br J Pharmacol , vol.128 , pp. 428-434
    • Szallasi, A.1    Szabo, T.2    Biro, T.3
  • 49
    • 77953271751 scopus 로고    scopus 로고
    • A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain
    • C.J. Bohlen, A. Priel, S. Zhou, D. King, J. Siemens, and D. Julius A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain Cell 141 2010 834 845
    • (2010) Cell , vol.141 , pp. 834-845
    • Bohlen, C.J.1    Priel, A.2    Zhou, S.3    King, D.4    Siemens, J.5    Julius, D.6
  • 50
    • 33750873334 scopus 로고    scopus 로고
    • Spider toxins activate the capsaicin receptor to produce inflammatory pain
    • J. Siemens, S. Zhou, and R. Piskorowski Spider toxins activate the capsaicin receptor to produce inflammatory pain Nature 444 2006 208 212
    • (2006) Nature , vol.444 , pp. 208-212
    • Siemens, J.1    Zhou, S.2    Piskorowski, R.3
  • 51
    • 30544435419 scopus 로고    scopus 로고
    • Hydrogen sulfide causes vanilloid receptor 1-mediated neurogenic inflammation in the airways
    • M. Trevisani, R. Patacchini, and P. Nicoletti Hydrogen sulfide causes vanilloid receptor 1-mediated neurogenic inflammation in the airways Br J Pharmacol 145 2005 1123 1131
    • (2005) Br J Pharmacol , vol.145 , pp. 1123-1131
    • Trevisani, M.1    Patacchini, R.2    Nicoletti, P.3
  • 52
    • 2442498381 scopus 로고    scopus 로고
    • Molecular determinants of vanilloid sensitivity in TRPV1
    • N.R. Gavva, L. Klionsky, and Y. Qu Molecular determinants of vanilloid sensitivity in TRPV1 J Biol Chem 279 2004 20283 20295
    • (2004) J Biol Chem , vol.279 , pp. 20283-20295
    • Gavva, N.R.1    Klionsky, L.2    Qu, Y.3
  • 53
    • 0036183319 scopus 로고    scopus 로고
    • Molecular basis for species-specific sensitivity to "hot" chili peppers
    • S.E. Jordt, and D. Julius Molecular basis for species-specific sensitivity to "hot" chili peppers Cell 108 2002 421 430
    • (2002) Cell , vol.108 , pp. 421-430
    • Jordt, S.E.1    Julius, D.2
  • 54
    • 23244441222 scopus 로고    scopus 로고
    • Voltage sensor of Kv1.2: Structural basis of electromechanical coupling
    • S.B. Long, E.B. Campbell, and R. Mackinnon Voltage sensor of Kv1.2: structural basis of electromechanical coupling Science 309 2005 903 908
    • (2005) Science , vol.309 , pp. 903-908
    • Long, S.B.1    Campbell, E.B.2    Mackinnon, R.3
  • 55
    • 34748848687 scopus 로고    scopus 로고
    • Closing in on the resting state of the Shaker K(+) channel
    • M.M. Pathak, V. Yarov-Yarovoy, and G. Agarwal Closing in on the resting state of the Shaker K(+) channel Neuron 56 2007 124 140
    • (2007) Neuron , vol.56 , pp. 124-140
    • Pathak, M.M.1    Yarov-Yarovoy, V.2    Agarwal, G.3
  • 56
    • 4043077669 scopus 로고    scopus 로고
    • The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels
    • T. Voets, G. Droogmans, U. Wissenbach, A. Janssens, V. Flockerzi, and B. Nilius The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels Nature 430 2004 748 754
    • (2004) Nature , vol.430 , pp. 748-754
    • Voets, T.1    Droogmans, G.2    Wissenbach, U.3    Janssens, A.4    Flockerzi, V.5    Nilius, B.6
  • 57
    • 42649095142 scopus 로고    scopus 로고
    • TRPV1 shows dynamic ionic selectivity during agonist stimulation
    • M.-K. Chung, A.D. Guler, and M.J. Caterina TRPV1 shows dynamic ionic selectivity during agonist stimulation Nat Neurosci 11 2008 555 564
    • (2008) Nat Neurosci , vol.11 , pp. 555-564
    • Chung, M.-K.1    Guler, A.D.2    Caterina, M.J.3
  • 58
    • 0038721194 scopus 로고    scopus 로고
    • A tyrosine residue in TM6 of the vanilloid receptor TRPV1 involved in desensitization and calcium permeability of capsaicin-activated currents
    • D.P. Mohapatra, S.Y. Wang, G.K. Wang, and C. Nau A tyrosine residue in TM6 of the vanilloid receptor TRPV1 involved in desensitization and calcium permeability of capsaicin-activated currents Mol Cell Neurosci 23 2003 314 324
    • (2003) Mol Cell Neurosci , vol.23 , pp. 314-324
    • Mohapatra, D.P.1    Wang, S.Y.2    Wang, G.K.3    Nau, C.4
  • 59
    • 0030956114 scopus 로고    scopus 로고
    • The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons
    • P.A. Koplas, R.L. Rosenberg, and G.S. Oxford The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons J Neurosci 17 1997 3525 3537
    • (1997) J Neurosci , vol.17 , pp. 3525-3537
    • Koplas, P.A.1    Rosenberg, R.L.2    Oxford, G.S.3
  • 60
    • 84865469570 scopus 로고    scopus 로고
    • The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical Gbetagamma-dependent modulation of TRPV1 channel
    • L. Loo, A.J. Shepherd, and A.D. Mickle The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical Gbetagamma-dependent modulation of TRPV1 channel J Neurosci 32 2012 11942 11955
    • (2012) J Neurosci , vol.32 , pp. 11942-11955
    • Loo, L.1    Shepherd, A.J.2    Mickle, A.D.3
  • 61
    • 0029965156 scopus 로고    scopus 로고
    • Inhibition of calcineurin inhibits the desensitization of capsaicin-evoked currents in cultured dorsal root ganglion neurones from adult rats
    • R.J. Docherty, J.C. Yeats, S. Bevan, and H.W. Boddeke Inhibition of calcineurin inhibits the desensitization of capsaicin-evoked currents in cultured dorsal root ganglion neurones from adult rats Pflugers Arch 431 1996 828 837
    • (1996) Pflugers Arch , vol.431 , pp. 828-837
    • Docherty, R.J.1    Yeats, J.C.2    Bevan, S.3    Boddeke, H.W.4
  • 62
    • 17144397173 scopus 로고    scopus 로고
    • 2 +-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase
    • 2 +-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase J Biol Chem 280 2005 13424 13432
    • (2005) J Biol Chem , vol.280 , pp. 13424-13432
    • Mohapatra, D.P.1    Nau, C.2
  • 64
    • 78149479471 scopus 로고    scopus 로고
    • IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex
    • O.K. Melemedjian, M.N. Asiedu, and D.V. Tillu IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex J Neurosci 30 2010 15113 15123
    • (2010) J Neurosci , vol.30 , pp. 15113-15123
    • Melemedjian, O.K.1    Asiedu, M.N.2    Tillu, D.V.3
  • 65
    • 84904424376 scopus 로고    scopus 로고
    • Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity
    • O.K. Melemedjian, D.V. Tillu, and J.K. Moy Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity Mol Pain 10 2014 45
    • (2014) Mol Pain , vol.10 , pp. 45
    • Melemedjian, O.K.1    Tillu, D.V.2    Moy, J.K.3
  • 66
    • 0142059776 scopus 로고    scopus 로고
    • Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)
    • G. Bhave, H.-J. Hu, and K.S. Glauner Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) Proc Natl Acad Sci USA 100 2003 12480 12485
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12480-12485
    • Bhave, G.1    Hu, H.-J.2    Glauner, K.S.3
  • 67
    • 0037104657 scopus 로고    scopus 로고
    • CAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation
    • G. Bhave, W. Zhu, H. Wang, D.J. Brasier, G.S. Oxford, and R.W. Gereau Iv cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation Neuron 35 2002 721 731
    • (2002) Neuron , vol.35 , pp. 721-731
    • Bhave, G.1    Zhu, W.2    Wang, H.3    Brasier, D.J.4    Oxford, G.S.5    Gereau Iv, R.W.6
  • 69
    • 1342346561 scopus 로고    scopus 로고
    • 2 +/calmodulin-dependent kinase II regulates its vanilloid binding
    • 2 +/calmodulin-dependent kinase II regulates its vanilloid binding J Biol Chem 279 2004 7048 7054
    • (2004) J Biol Chem , vol.279 , pp. 7048-7054
    • Jung, J.1    Shin, J.S.2    Lee, S.Y.3
  • 70
    • 0037134417 scopus 로고    scopus 로고
    • Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues
    • M. Numazaki, T. Tominaga, H. Toyooka, and M. Tominaga Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues J Biol Chem 277 2002 13375 13378
    • (2002) J Biol Chem , vol.277 , pp. 13375-13378
    • Numazaki, M.1    Tominaga, T.2    Toyooka, H.3    Tominaga, M.4
  • 71
    • 33846293924 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1
    • T.K. Pareek, J. Keller, and S. Kesavapany Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1 Proc Natl Acad Sci USA 104 2007 660 665
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 660-665
    • Pareek, T.K.1    Keller, J.2    Kesavapany, S.3
  • 72
    • 0035425705 scopus 로고    scopus 로고
    • Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide
    • V. Vellani, S. Mapplebeck, A. Moriondo, J.B. Davis, and P.A. McNaughton Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide J Physiol 534 2001 813 825
    • (2001) J Physiol , vol.534 , pp. 813-825
    • Vellani, V.1    Mapplebeck, S.2    Moriondo, A.3    Davis, J.B.4    McNaughton, P.A.5
  • 73
    • 29244484493 scopus 로고    scopus 로고
    • NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels
    • X. Zhang, J. Huang, and P.A. McNaughton NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels EMBO J 24 2005 4211 4223
    • (2005) EMBO J , vol.24 , pp. 4211-4223
    • Zhang, X.1    Huang, J.2    McNaughton, P.A.3
  • 74
    • 0346118925 scopus 로고    scopus 로고
    • Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway
    • D.P. Mohapatra, and C. Nau Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway J Biol Chem 278 2003 50080 50090
    • (2003) J Biol Chem , vol.278 , pp. 50080-50090
    • Mohapatra, D.P.1    Nau, C.2
  • 75
    • 0037179755 scopus 로고    scopus 로고
    • P38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
    • R.R. Ji, T.A. Samad, S.X. Jin, R. Schmoll, and C.J. Woolf p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia Neuron 36 2002 57 68
    • (2002) Neuron , vol.36 , pp. 57-68
    • Ji, R.R.1    Samad, T.A.2    Jin, S.X.3    Schmoll, R.4    Woolf, C.J.5
  • 76
    • 33750510073 scopus 로고    scopus 로고
    • Why pain gets worse: The mechanism of heat hyperalgesia
    • X. Zhang, and P.A. McNaughton Why pain gets worse: the mechanism of heat hyperalgesia J Gen Physiol 128 2006 491 493
    • (2006) J Gen Physiol , vol.128 , pp. 491-493
    • Zhang, X.1    McNaughton, P.A.2
  • 77
    • 0035927651 scopus 로고    scopus 로고
    • Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
    • H.H. Chuang, E.D. Prescott, and H. Kong Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition Nature 411 2001 957 962
    • (2001) Nature , vol.411 , pp. 957-962
    • Chuang, H.H.1    Prescott, E.D.2    Kong, H.3
  • 78
    • 84880435653 scopus 로고    scopus 로고
    • Distinctive changes in plasma membrane phosphoinositides underlie differential regulation of TRPV1 in nociceptive neurons
    • V. Lukacs, Y. Yudin, G.R. Hammond, E. Sharma, K. Fukami, and T. Rohacs Distinctive changes in plasma membrane phosphoinositides underlie differential regulation of TRPV1 in nociceptive neurons J Neurosci 33 2013 11451 11463
    • (2013) J Neurosci , vol.33 , pp. 11451-11463
    • Lukacs, V.1    Yudin, Y.2    Hammond, G.R.3    Sharma, E.4    Fukami, K.5    Rohacs, T.6
  • 79
    • 84885786957 scopus 로고    scopus 로고
    • Regulation of transient receptor potential channels by the phospholipase C pathway
    • T. Rohacs Regulation of transient receptor potential channels by the phospholipase C pathway Adv Biol Regul 53 2013 341 355
    • (2013) Adv Biol Regul , vol.53 , pp. 341-355
    • Rohacs, T.1
  • 80
    • 26444511606 scopus 로고    scopus 로고
    • Structure and function of TRPV1
    • M. Tominaga, and T. Tominaga Structure and function of TRPV1 Pflugers Arch 451 2005 143 150
    • (2005) Pflugers Arch , vol.451 , pp. 143-150
    • Tominaga, M.1    Tominaga, T.2
  • 82
    • 0034646740 scopus 로고    scopus 로고
    • Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    • M.J. Caterina, A. Leffler, and A.B. Malmberg Impaired nociception and pain sensation in mice lacking the capsaicin receptor Science 288 2000 306 313
    • (2000) Science , vol.288 , pp. 306-313
    • Caterina, M.J.1    Leffler, A.2    Malmberg, A.B.3
  • 83
    • 0034636441 scopus 로고    scopus 로고
    • Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
    • J.B. Davis, J. Gray, and M.J. Gunthorpe Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia Nature 405 2000 183 187
    • (2000) Nature , vol.405 , pp. 183-187
    • Davis, J.B.1    Gray, J.2    Gunthorpe, M.J.3
  • 85
    • 33750323945 scopus 로고    scopus 로고
    • Attenuation of experimental arthritis in TRPV1R knockout mice
    • N.J. Barton, D.S. McQueen, and D. Thomson Attenuation of experimental arthritis in TRPV1R knockout mice Exp Mol Pathol 81 2006 166 170
    • (2006) Exp Mol Pathol , vol.81 , pp. 166-170
    • Barton, N.J.1    McQueen, D.S.2    Thomson, D.3
  • 86
    • 84918588843 scopus 로고    scopus 로고
    • Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain
    • S. Kelly, R.J. Chapman, and S. Woodhams Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain Ann Rheum Dis 74 2015 252 259
    • (2015) Ann Rheum Dis , vol.74 , pp. 252-259
    • Kelly, S.1    Chapman, R.J.2    Woodhams, S.3
  • 87
    • 80051474349 scopus 로고    scopus 로고
    • The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis
    • A.M. Valdes, G. De Wilde, and S.A. Doherty The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis Ann Rheum Dis 70 2011 1556 1561
    • (2011) Ann Rheum Dis , vol.70 , pp. 1556-1561
    • Valdes, A.M.1    De Wilde, G.2    Doherty, S.A.3
  • 88
    • 20144388484 scopus 로고    scopus 로고
    • Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain
    • J.R. Ghilardi, H. Rohrich, and T.H. Lindsay Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain J Neurosci 25 2005 3126 3131
    • (2005) J Neurosci , vol.25 , pp. 3126-3131
    • Ghilardi, J.R.1    Rohrich, H.2    Lindsay, T.H.3
  • 89
    • 84888640113 scopus 로고    scopus 로고
    • Bone cancer pain: Causes, consequences, and therapeutic opportunities
    • P. Mantyh Bone cancer pain: causes, consequences, and therapeutic opportunities Pain 154 Suppl 1 2013 S54 S62
    • (2013) Pain , vol.154 , pp. S54-S62
    • Mantyh, P.1
  • 90
    • 4444318878 scopus 로고    scopus 로고
    • Anandamide acts as a vasodilator of dural blood vessels in vivo by activating TRPV1 receptors
    • S. Akerman, H. Kaube, and P.J. Goadsby Anandamide acts as a vasodilator of dural blood vessels in vivo by activating TRPV1 receptors Br J Pharmacol 142 2004 1354 1360
    • (2004) Br J Pharmacol , vol.142 , pp. 1354-1360
    • Akerman, S.1    Kaube, H.2    Goadsby, P.J.3
  • 92
    • 2442713905 scopus 로고    scopus 로고
    • Ethanol causes inflammation in the airways by a neurogenic and TRPV1-dependent mechanism
    • M. Trevisani, D. Gazzieri, and F. Benvenuti Ethanol causes inflammation in the airways by a neurogenic and TRPV1-dependent mechanism J Pharmacol Exp Ther 309 2004 1167 1173
    • (2004) J Pharmacol Exp Ther , vol.309 , pp. 1167-1173
    • Trevisani, M.1    Gazzieri, D.2    Benvenuti, F.3
  • 93
    • 85047696992 scopus 로고    scopus 로고
    • Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1
    • M. Trevisani, D. Smart, and M.J. Gunthorpe Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1 Nat Neurosci 5 2002 546 551
    • (2002) Nat Neurosci , vol.5 , pp. 546-551
    • Trevisani, M.1    Smart, D.2    Gunthorpe, M.J.3
  • 94
    • 79956046587 scopus 로고    scopus 로고
    • Characterization of dental nociceptive neurons
    • H.Y. Kim, G. Chung, and H.J. Jo Characterization of dental nociceptive neurons J Dent Res 90 2011 771 776
    • (2011) J Dent Res , vol.90 , pp. 771-776
    • Kim, H.Y.1    Chung, G.2    Jo, H.J.3
  • 95
    • 33745212252 scopus 로고    scopus 로고
    • Functional expression of thermo-transient receptor potential channels in dental primary afferent neurons: Implication for tooth pain
    • C.K. Park, M.S. Kim, and Z. Fang Functional expression of thermo-transient receptor potential channels in dental primary afferent neurons: implication for tooth pain J Biol Chem 281 2006 17304 17311
    • (2006) J Biol Chem , vol.281 , pp. 17304-17311
    • Park, C.K.1    Kim, M.S.2    Fang, Z.3
  • 96
    • 80051751960 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced pulpitis up-regulates TRPV1 in trigeminal ganglia
    • M.K. Chung, J. Lee, G. Duraes, and J.Y. Ro Lipopolysaccharide-induced pulpitis up-regulates TRPV1 in trigeminal ganglia J Dent Res 90 2011 1103 1107
    • (2011) J Dent Res , vol.90 , pp. 1103-1107
    • Chung, M.K.1    Lee, J.2    Duraes, G.3    Ro, J.Y.4
  • 97
    • 84876079130 scopus 로고    scopus 로고
    • TRP channels in dental pain
    • G. Chung, and S.B. Oh TRP channels in dental pain Open Pain J 6 2013 31 36
    • (2013) Open Pain J , vol.6 , pp. 31-36
    • Chung, G.1    Oh, S.B.2
  • 99
    • 11144255122 scopus 로고    scopus 로고
    • Vanilloid receptor 1 antagonists attenuate disease severity in dextran sulphate sodium-induced colitis in mice
    • E.S. Kimball, N.H. Wallace, C.R. Schneider, M.R. D'Andrea, and P.J. Hornby Vanilloid receptor 1 antagonists attenuate disease severity in dextran sulphate sodium-induced colitis in mice Neurogastroenterol Motil. 16 2004 811 818
    • (2004) Neurogastroenterol Motil. , vol.16 , pp. 811-818
    • Kimball, E.S.1    Wallace, N.H.2    Schneider, C.R.3    D'Andrea, M.R.4    Hornby, P.J.5
  • 100
    • 0037309871 scopus 로고    scopus 로고
    • Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency
    • C.L. Chan, P. Facer, and J.B. Davis Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency Lancet 361 2003 385 391
    • (2003) Lancet , vol.361 , pp. 385-391
    • Chan, C.L.1    Facer, P.2    Davis, J.B.3
  • 101
    • 51549091407 scopus 로고    scopus 로고
    • Lack of TRPV1 inhibits cystitis-induced increased mechanical sensitivity in mice
    • Z.Y. Wang, P. Wang, F.V. Merriam, and D.E. Bjorling Lack of TRPV1 inhibits cystitis-induced increased mechanical sensitivity in mice Pain 139 2008 158 167
    • (2008) Pain , vol.139 , pp. 158-167
    • Wang, Z.Y.1    Wang, P.2    Merriam, F.V.3    Bjorling, D.E.4
  • 102
    • 34447099726 scopus 로고    scopus 로고
    • Short-term sensitization of colon mechanoreceptors is associated with long-term hypersensitivity to colon distention in the mouse
    • R.C. Jones III., E. Otsuka, E. Wagstrom, C.S. Jensen, M.P. Price, and G.F. Gebhart Short-term sensitization of colon mechanoreceptors is associated with long-term hypersensitivity to colon distention in the mouse Gastroenterology 133 2007 184 194
    • (2007) Gastroenterology , vol.133 , pp. 184-194
    • Jones, R.C.1    Otsuka, E.2    Wagstrom, E.3    Jensen, C.S.4    Price, M.P.5    Gebhart, G.F.6
  • 103
    • 28044453285 scopus 로고    scopus 로고
    • The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require transient receptor potential vanilloid 1 and acid-sensing ion channel 3
    • R.C. Jones III., L. Xu, and G.F. Gebhart The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require transient receptor potential vanilloid 1 and acid-sensing ion channel 3 J Neurosci 25 2005 10981 10989
    • (2005) J Neurosci , vol.25 , pp. 10981-10989
    • Jones, R.C.1    Xu, L.2    Gebhart, G.F.3
  • 104
    • 32044436722 scopus 로고    scopus 로고
    • Vanilloid receptor (TRPV1)-deficient mice show increased susceptibility to dinitrobenzene sulfonic acid induced colitis
    • F. Massa, A. Sibaev, G. Marsicano, H. Blaudzun, M. Storr, and B. Lutz Vanilloid receptor (TRPV1)-deficient mice show increased susceptibility to dinitrobenzene sulfonic acid induced colitis J Mol Med 84 2006 142 146
    • (2006) J Mol Med , vol.84 , pp. 142-146
    • Massa, F.1    Sibaev, A.2    Marsicano, G.3    Blaudzun, H.4    Storr, M.5    Lutz, B.6
  • 105
    • 34447500674 scopus 로고    scopus 로고
    • TRPV1 in colitis: Is it a good or a bad receptor? A viewpoint
    • M. Storr TRPV1 in colitis: is it a good or a bad receptor? A viewpoint Neurogastroenterol Motil 19 2007 625 629
    • (2007) Neurogastroenterol Motil , vol.19 , pp. 625-629
    • Storr, M.1
  • 106
    • 0342437490 scopus 로고    scopus 로고
    • Suppression of bladder hyperreflexia by intravesical resiniferatoxin
    • F. Cruz, M. Guimaraes, C. Silva, and M. Reis Suppression of bladder hyperreflexia by intravesical resiniferatoxin Lancet 350 1997 640 641
    • (1997) Lancet , vol.350 , pp. 640-641
    • Cruz, F.1    Guimaraes, M.2    Silva, C.3    Reis, M.4
  • 107
    • 17644411712 scopus 로고    scopus 로고
    • Differential responses of bladder lumbosacral and thoracolumbar dorsal root ganglion neurons to purinergic agonists, protons, and capsaicin
    • K. Dang, K. Bielefeldt, and G.F. Gebhart Differential responses of bladder lumbosacral and thoracolumbar dorsal root ganglion neurons to purinergic agonists, protons, and capsaicin J Neurosci 25 2005 3973 3984
    • (2005) J Neurosci , vol.25 , pp. 3973-3984
    • Dang, K.1    Bielefeldt, K.2    Gebhart, G.F.3
  • 108
    • 47749116508 scopus 로고    scopus 로고
    • TRPV1: A target for next generation analgesics
    • L.S. Premkumar, and P. Sikand TRPV1: a target for next generation analgesics Curr Neuropharmacol 6 2008 151 163
    • (2008) Curr Neuropharmacol , vol.6 , pp. 151-163
    • Premkumar, L.S.1    Sikand, P.2
  • 109
    • 3242772894 scopus 로고    scopus 로고
    • Intravesical resiniferatoxin decreases spinal c-fos expression and increases bladder volume to reflex micturition in rats with chronic inflamed urinary bladders
    • P. Dinis, A. Charrua, A. Avelino, and F. Cruz Intravesical resiniferatoxin decreases spinal c-fos expression and increases bladder volume to reflex micturition in rats with chronic inflamed urinary bladders BJU Int 94 2004 153 157
    • (2004) BJU Int , vol.94 , pp. 153-157
    • Dinis, P.1    Charrua, A.2    Avelino, A.3    Cruz, F.4
  • 110
    • 41749117999 scopus 로고    scopus 로고
    • Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans
    • N.R. Gavva, J.J. Treanor, and A. Garami Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans Pain 136 2008 202 210
    • (2008) Pain , vol.136 , pp. 202-210
    • Gavva, N.R.1    Treanor, J.J.2    Garami, A.3
  • 111
    • 84898822647 scopus 로고    scopus 로고
    • No requirement of TRPV1 in long-term potentiation or long-term depression in the anterior cingulate cortex
    • M.G. Liu, and M. Zhuo No requirement of TRPV1 in long-term potentiation or long-term depression in the anterior cingulate cortex Mol Pain 7 2014 27
    • (2014) Mol Pain , vol.7 , pp. 27
    • Liu, M.G.1    Zhuo, M.2
  • 112
    • 35548999215 scopus 로고    scopus 로고
    • Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs
    • A. Bhattacharya, B.P. Scott, and N. Nasser Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs J Pharmacol Exp Ther 323 2007 665 674
    • (2007) J Pharmacol Exp Ther , vol.323 , pp. 665-674
    • Bhattacharya, A.1    Scott, B.P.2    Nasser, N.3
  • 113
    • 33644806753 scopus 로고    scopus 로고
    • The transient receptor potential vanilloid 1: Role in airway inflammation and disease
    • P. Geppetti, S. Materazzi, and P. Nicoletti The transient receptor potential vanilloid 1: role in airway inflammation and disease Eur J Pharmacol 533 2006 207 214
    • (2006) Eur J Pharmacol , vol.533 , pp. 207-214
    • Geppetti, P.1    Materazzi, S.2    Nicoletti, P.3
  • 114
    • 39449102203 scopus 로고    scopus 로고
    • Peripheral TRPV1 receptors as targets for drug development: New molecules and mechanisms
    • M.J. Gunthorpe, and A. Szallasi Peripheral TRPV1 receptors as targets for drug development: new molecules and mechanisms Curr Pharm Des 14 2008 32 41
    • (2008) Curr Pharm des , vol.14 , pp. 32-41
    • Gunthorpe, M.J.1    Szallasi, A.2
  • 115
    • 18944406302 scopus 로고    scopus 로고
    • TRPV1 receptor: A target for the treatment of pain, cough, airway disease and urinary incontinence
    • Y. Jia, R.L. McLeod, and J.A. Hey TRPV1 receptor: a target for the treatment of pain, cough, airway disease and urinary incontinence Drug News Perspect 18 2005 165 171
    • (2005) Drug News Perspect , vol.18 , pp. 165-171
    • Jia, Y.1    McLeod, R.L.2    Hey, J.A.3
  • 116
    • 33747227271 scopus 로고    scopus 로고
    • Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice
    • S. Amadesi, G.S. Cottrell, and L. Divino Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice J Physiol 575 2006 555 571
    • (2006) J Physiol , vol.575 , pp. 555-571
    • Amadesi, S.1    Cottrell, G.S.2    Divino, L.3
  • 117
    • 33746662945 scopus 로고    scopus 로고
    • Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs
    • R. Gatti, E. Andre, and S. Amadesi Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs J Appl Physiol 101 2006 506 511
    • (2006) J Appl Physiol , vol.101 , pp. 506-511
    • Gatti, R.1    Andre, E.2    Amadesi, S.3
  • 118
    • 33845382786 scopus 로고    scopus 로고
    • TRPV1 + sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes
    • R. Razavi, Y. Chan, and F.N. Afifiyan TRPV1 + sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes Cell 127 2006 1123 1135
    • (2006) Cell , vol.127 , pp. 1123-1135
    • Razavi, R.1    Chan, Y.2    Afifiyan, F.N.3
  • 119
    • 77950436208 scopus 로고    scopus 로고
    • TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats
    • S. McGaraughty, K. Chu, R. Perner, S. DiDomenico, M. Kort, and P. Kym TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats Mol Pain 6 2010 14
    • (2010) Mol Pain , vol.6 , pp. 14
    • McGaraughty, S.1    Chu, K.2    Perner, R.3    Didomenico, S.4    Kort, M.5    Kym, P.6
  • 120
    • 84864147863 scopus 로고    scopus 로고
    • Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature
    • R.M. Reilly, H.A. McDonald, and P.S. Puttfarcken Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature J Pharmacol Exp Ther 342 2012 416 428
    • (2012) J Pharmacol Exp Ther , vol.342 , pp. 416-428
    • Reilly, R.M.1    McDonald, H.A.2    Puttfarcken, P.S.3
  • 121
    • 27644551317 scopus 로고    scopus 로고
    • Physiologic and antinociceptive effects of intrathecal resiniferatoxin in a canine bone cancer model
    • D.C. Brown, M.J. Iadarola, and S.Z. Perkowski Physiologic and antinociceptive effects of intrathecal resiniferatoxin in a canine bone cancer model Anesthesiology 103 2005 1052 1059
    • (2005) Anesthesiology , vol.103 , pp. 1052-1059
    • Brown, D.C.1    Iadarola, M.J.2    Perkowski, S.Z.3
  • 122
    • 84876089233 scopus 로고    scopus 로고
    • Resiniferatoxin for pain treatment: An interventional approach to personalized pain medicine
    • M.J. Iadarola, and G.L. Gonnella Resiniferatoxin for pain treatment: an interventional approach to personalized pain medicine Open Pain J 6 2013 95 107
    • (2013) Open Pain J , vol.6 , pp. 95-107
    • Iadarola, M.J.1    Gonnella, G.L.2
  • 123
    • 20244375697 scopus 로고    scopus 로고
    • Intravesical resiniferatoxin for the treatment of interstitial cystitis: A randomized, double-blind, placebo controlled trial
    • C.K. Payne, P.G. Mosbaugh, and J.B. Forrest Intravesical resiniferatoxin for the treatment of interstitial cystitis: a randomized, double-blind, placebo controlled trial J Urol 173 2005 1590 1594
    • (2005) J Urol , vol.173 , pp. 1590-1594
    • Payne, C.K.1    Mosbaugh, P.G.2    Forrest, J.B.3
  • 124
    • 0033119629 scopus 로고    scopus 로고
    • A capsaicin-receptor homologue with a high threshold for noxious heat
    • M.J. Caterina, T.A. Rosen, M. Tominaga, A.J. Brake, and D. Julius A capsaicin-receptor homologue with a high threshold for noxious heat Nature 398 1999 436 441
    • (1999) Nature , vol.398 , pp. 436-441
    • Caterina, M.J.1    Rosen, T.A.2    Tominaga, M.3    Brake, A.J.4    Julius, D.5
  • 125
    • 3242784060 scopus 로고    scopus 로고
    • A TRPV2-PKA signaling module for transduction of physical stimuli in mast cells
    • A.J. Stokes, L.M. Shimoda, M. Koblan-Huberson, C.N. Adra, and H. Turner A TRPV2-PKA signaling module for transduction of physical stimuli in mast cells J Exp Med 200 2004 137 147
    • (2004) J Exp Med , vol.200 , pp. 137-147
    • Stokes, A.J.1    Shimoda, L.M.2    Koblan-Huberson, M.3    Adra, C.N.4    Turner, H.5
  • 127
    • 80051556902 scopus 로고    scopus 로고
    • TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception
    • U. Park, N. Vastani, Y. Guan, S.N. Raja, M. Koltzenburg, and M.J. Caterina TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception J Neurosci 31 2011 11425 11436
    • (2011) J Neurosci , vol.31 , pp. 11425-11436
    • Park, U.1    Vastani, N.2    Guan, Y.3    Raja, S.N.4    Koltzenburg, M.5    Caterina, M.J.6
  • 128
    • 0037077041 scopus 로고    scopus 로고
    • A heat-sensitive TRP channel expressed in keratinocytes
    • A.M. Peier, A.J. Reeve, and D.A. Andersson A heat-sensitive TRP channel expressed in keratinocytes Science 296 2002 2046 2049
    • (2002) Science , vol.296 , pp. 2046-2049
    • Peier, A.M.1    Reeve, A.J.2    Andersson, D.A.3
  • 129
    • 0037062915 scopus 로고    scopus 로고
    • TRPV3 is a calcium-permeable temperature-sensitive cation channel
    • H. Xu, I.S. Ramsey, and S.A. Kotecha TRPV3 is a calcium-permeable temperature-sensitive cation channel Nature 418 2002 181 186
    • (2002) Nature , vol.418 , pp. 181-186
    • Xu, H.1    Ramsey, I.S.2    Kotecha, S.A.3
  • 131
    • 84865295536 scopus 로고    scopus 로고
    • Evidence TRPV4 contributes to mechanosensitive ion channels in mouse skeletal muscle fibers
    • T.C. Ho, N.A. Horn, T. Huynh, L. Kelava, and J.B. Lansman Evidence TRPV4 contributes to mechanosensitive ion channels in mouse skeletal muscle fibers Channels (Austin) 6 2012 246 254
    • (2012) Channels (Austin) , vol.6 , pp. 246-254
    • Ho, T.C.1    Horn, N.A.2    Huynh, T.3    Kelava, L.4    Lansman, J.B.5
  • 132
    • 84873413090 scopus 로고    scopus 로고
    • The puzzle of TRPV4 channelopathies
    • B. Nilius, and T. Voets The puzzle of TRPV4 channelopathies EMBO Rep 14 2013 152 163
    • (2013) EMBO Rep , vol.14 , pp. 152-163
    • Nilius, B.1    Voets, T.2
  • 133
    • 84869101137 scopus 로고    scopus 로고
    • TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis
    • L. Ye, S. Kleiner, and J. Wu TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis Cell 151 2012 96 110
    • (2012) Cell , vol.151 , pp. 96-110
    • Ye, L.1    Kleiner, S.2    Wu, J.3
  • 134
    • 0043267987 scopus 로고    scopus 로고
    • Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
    • H. Watanabe, J. Vriens, J. Prenen, G. Droogmans, T. Voets, and B. Nilius Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels Nature 424 2003 434 438
    • (2003) Nature , vol.424 , pp. 434-438
    • Watanabe, H.1    Vriens, J.2    Prenen, J.3    Droogmans, G.4    Voets, T.5    Nilius, B.6
  • 135
    • 84912111747 scopus 로고    scopus 로고
    • TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel
    • J. Du, X. Ma, B. Shen, Y. Huang, L. Birnbaumer, and X. Yao TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel FASEB J 28 2014 4677 4685
    • (2014) FASEB J , vol.28 , pp. 4677-4685
    • Du, J.1    Ma, X.2    Shen, B.3    Huang, Y.4    Birnbaumer, L.5    Yao, X.6
  • 136
    • 38749148787 scopus 로고    scopus 로고
    • Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia
    • N. Alessandri-Haber, O.A. Dina, E.K. Joseph, D.B. Reichling, and J.D. Levine Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia J Neurosci 28 2008 1046 1057
    • (2008) J Neurosci , vol.28 , pp. 1046-1057
    • Alessandri-Haber, N.1    Dina, O.A.2    Joseph, E.K.3    Reichling, D.B.4    Levine, J.D.5
  • 137
    • 0041695412 scopus 로고    scopus 로고
    • Hypotonicity induces TRPV4-mediated nociception in rat
    • N. Alessandri-Haber, J.J. Yeh, and A.E. Boyd Hypotonicity induces TRPV4-mediated nociception in rat Neuron 39 2003 497 511
    • (2003) Neuron , vol.39 , pp. 497-511
    • Alessandri-Haber, N.1    Yeh, J.J.2    Boyd, A.E.3
  • 138
    • 84861825585 scopus 로고    scopus 로고
    • Role of transient receptor potential vanilloid 4 in rat joint inflammation
    • A. Denadai-Souza, L. Martin, and M.A. de Paula Role of transient receptor potential vanilloid 4 in rat joint inflammation Arthritis Rheum 64 2012 1848 1858
    • (2012) Arthritis Rheum , vol.64 , pp. 1848-1858
    • Denadai-Souza, A.1    Martin, L.2    De Paula, M.A.3
  • 139
    • 59149106559 scopus 로고    scopus 로고
    • Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli
    • T. Wegierski, U. Lewandrowski, B. Muller, A. Sickmann, and G. Walz Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli J Biol Chem 284 2009 2923 2933
    • (2009) J Biol Chem , vol.284 , pp. 2923-2933
    • Wegierski, T.1    Lewandrowski, U.2    Muller, B.3    Sickmann, A.4    Walz, G.5
  • 140
    • 27644447312 scopus 로고    scopus 로고
    • TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator
    • N. Alessandri-Haber, E. Joseph, O.A. Dina, W. Liedtke, and J.D. Levine TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator Pain 118 2005 70 79
    • (2005) Pain , vol.118 , pp. 70-79
    • Alessandri-Haber, N.1    Joseph, E.2    Dina, O.A.3    Liedtke, W.4    Levine, J.D.5
  • 142
    • 0344630199 scopus 로고    scopus 로고
    • Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans
    • W. Liedtke, D.M. Tobin, C.I. Bargmann, and J.M. Friedman Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans Proc Natl Acad Sci USA 100 Suppl 2 2003 14531 14536
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 14531-14536
    • Liedtke, W.1    Tobin, D.M.2    Bargmann, C.I.3    Friedman, J.M.4
  • 143
    • 0038604287 scopus 로고    scopus 로고
    • Impaired pressure sensation in mice lacking TRPV4
    • M. Suzuki, A. Mizuno, K. Kodaira, and M. Imai Impaired pressure sensation in mice lacking TRPV4 J Biol Chem 278 2003 22664 22668
    • (2003) J Biol Chem , vol.278 , pp. 22664-22668
    • Suzuki, M.1    Mizuno, A.2    Kodaira, K.3    Imai, M.4
  • 144
    • 4143079214 scopus 로고    scopus 로고
    • Warm temperature-sensitive transient receptor potential vanilloid 4 (TRPV4) plays an essential role in thermal hyperalgesia
    • H. Todaka, J. Taniguchi, J. Satoh, A. Mizuno, and M. Suzuki Warm temperature-sensitive transient receptor potential vanilloid 4 (TRPV4) plays an essential role in thermal hyperalgesia J Biol Chem 279 2004 35133 35138
    • (2004) J Biol Chem , vol.279 , pp. 35133-35138
    • Todaka, H.1    Taniguchi, J.2    Satoh, J.3    Mizuno, A.4    Suzuki, M.5
  • 145
    • 77957014371 scopus 로고    scopus 로고
    • Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice
    • E. Ceppa, F. Cattaruzza, and V. Lyo Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice Am J Physiol Gastrointest Liver Physiol 299 2010 G556 G571
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.299 , pp. G556-G571
    • Ceppa, E.1    Cattaruzza, F.2    Lyo, V.3
  • 146
    • 78650482651 scopus 로고    scopus 로고
    • Transient receptor potential vanilloid 4 activated inflammatory signals by intestinal epithelial cells and colitis in mice
    • E. D'Aldebert, N. Cenac, and P. Rousset Transient receptor potential vanilloid 4 activated inflammatory signals by intestinal epithelial cells and colitis in mice Gastroenterology 140 2011 275 285
    • (2011) Gastroenterology , vol.140 , pp. 275-285
    • D'Aldebert, E.1    Cenac, N.2    Rousset, P.3
  • 147
    • 79955667133 scopus 로고    scopus 로고
    • TRPM3 is a nociceptor channel involved in the detection of noxious heat
    • J. Vriens, G. Owsianik, and T. Hofmann TRPM3 is a nociceptor channel involved in the detection of noxious heat Neuron 70 2011 482 494
    • (2011) Neuron , vol.70 , pp. 482-494
    • Vriens, J.1    Owsianik, G.2    Hofmann, T.3
  • 148
    • 57049164233 scopus 로고    scopus 로고
    • Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells
    • T.F. Wagner, S. Loch, and S. Lambert Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells Nat Cell Biol 10 2008 1421 1430
    • (2008) Nat Cell Biol , vol.10 , pp. 1421-1430
    • Wagner, T.F.1    Loch, S.2    Lambert, S.3
  • 149
    • 0035807346 scopus 로고    scopus 로고
    • Physiology. Cold current in thermoreceptive neurons
    • G. Reid, and M.L. Flonta Physiology. Cold current in thermoreceptive neurons Nature 413 2001 480
    • (2001) Nature , vol.413 , pp. 480
    • Reid, G.1    Flonta, M.L.2
  • 150
    • 0037034931 scopus 로고    scopus 로고
    • Identification of a cold receptor reveals a general role for TRP channels in thermosensation
    • D.D. McKemy, W.M. Neuhausser, and D. Julius Identification of a cold receptor reveals a general role for TRP channels in thermosensation Nature 416 2002 52 58
    • (2002) Nature , vol.416 , pp. 52-58
    • McKemy, D.D.1    Neuhausser, W.M.2    Julius, D.3
  • 151
    • 18344386202 scopus 로고    scopus 로고
    • A TRP channel that senses cold stimuli and menthol
    • A.M. Peier, A. Moqrich, and A.C. Hergarden A TRP channel that senses cold stimuli and menthol Cell 108 2002 705 715
    • (2002) Cell , vol.108 , pp. 705-715
    • Peier, A.M.1    Moqrich, A.2    Hergarden, A.C.3
  • 152
    • 84857791792 scopus 로고    scopus 로고
    • Regulation of TRPM8 channel activity
    • Y. Yudin, and T. Rohacs Regulation of TRPM8 channel activity Mol Cell Endocrinol 353 2012 68 74
    • (2012) Mol Cell Endocrinol , vol.353 , pp. 68-74
    • Yudin, Y.1    Rohacs, T.2
  • 153
    • 38549180951 scopus 로고    scopus 로고
    • Visualizing cold spots: TRPM8-expressing sensory neurons and their projections
    • A. Dhaka, T.J. Earley, J. Watson, and A. Patapoutian Visualizing cold spots: TRPM8-expressing sensory neurons and their projections J Neurosci 28 2008 566 575
    • (2008) J Neurosci , vol.28 , pp. 566-575
    • Dhaka, A.1    Earley, T.J.2    Watson, J.3    Patapoutian, A.4
  • 154
    • 79958750586 scopus 로고    scopus 로고
    • A novel role for TRPM8 in visceral afferent function
    • A.M. Harrington, P.A. Hughes, and C.M. Martin A novel role for TRPM8 in visceral afferent function Pain 152 2011 1459 1468
    • (2011) Pain , vol.152 , pp. 1459-1468
    • Harrington, A.M.1    Hughes, P.A.2    Martin, C.M.3
  • 155
    • 38349101323 scopus 로고    scopus 로고
    • Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neurons
    • Y. Takashima, R.L. Daniels, W. Knowlton, J. Teng, E.R. Liman, and D.D. McKemy Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neurons J Neurosci 27 2007 14147 14157
    • (2007) J Neurosci , vol.27 , pp. 14147-14157
    • Takashima, Y.1    Daniels, R.L.2    Knowlton, W.3    Teng, J.4    Liman, E.R.5    McKemy, D.D.6
  • 156
    • 45849132683 scopus 로고    scopus 로고
    • TRPM8 mechanism of autonomic nerve response to cold in respiratory airway
    • H. Xing, J.X. Ling, and M. Chen TRPM8 mechanism of autonomic nerve response to cold in respiratory airway Mol Pain 4 2008 22
    • (2008) Mol Pain , vol.4 , pp. 22
    • Xing, H.1    Ling, J.X.2    Chen, M.3
  • 157
    • 18944382751 scopus 로고    scopus 로고
    • TRPM8 protein localization in trigeminal ganglion and taste papillae
    • J. Abe, H. Hosokawa, and M. Okazawa TRPM8 protein localization in trigeminal ganglion and taste papillae Brain Res Mol Brain Res 136 2005 91 98
    • (2005) Brain Res Mol Brain Res , vol.136 , pp. 91-98
    • Abe, J.1    Hosokawa, H.2    Okazawa, M.3
  • 159
    • 33645352477 scopus 로고    scopus 로고
    • High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol
    • M. Bandell, A.E. Dubin, and M.J. Petrus High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol Nat Neurosci 9 2006 493 500
    • (2006) Nat Neurosci , vol.9 , pp. 493-500
    • Bandell, M.1    Dubin, A.E.2    Petrus, M.J.3
  • 160
    • 14044261739 scopus 로고    scopus 로고
    • Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5-bisphosphate
    • B. Liu, and F. Qin Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5-bisphosphate J Neurosci 25 2005 1674 1681
    • (2005) J Neurosci , vol.25 , pp. 1674-1681
    • Liu, B.1    Qin, F.2
  • 161
    • 17844373771 scopus 로고    scopus 로고
    • PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain
    • T. Rohacs, C.M. Lopes, I. Michailidis, and D.E. Logothetis PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain Nat Neurosci 8 2005 626 634
    • (2005) Nat Neurosci , vol.8 , pp. 626-634
    • Rohacs, T.1    Lopes, C.M.2    Michailidis, I.3    Logothetis, D.E.4
  • 162
    • 77956799526 scopus 로고    scopus 로고
    • Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers
    • E. Zakharian, C. Cao, and T. Rohacs Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers J Neurosci 30 2010 12526 12534
    • (2010) J Neurosci , vol.30 , pp. 12526-12534
    • Zakharian, E.1    Cao, C.2    Rohacs, T.3
  • 163
    • 78349312518 scopus 로고    scopus 로고
    • Menthol inhibits the respiratory rhythm in brainstem preparations of the newborn rats
    • M. Tani, H. Onimaru, K. Ikeda, K. Kawakami, and I. Homma Menthol inhibits the respiratory rhythm in brainstem preparations of the newborn rats Neuroreport 21 2010 1095 1099
    • (2010) Neuroreport , vol.21 , pp. 1095-1099
    • Tani, M.1    Onimaru, H.2    Ikeda, K.3    Kawakami, K.4    Homma, I.5
  • 164
    • 34548610605 scopus 로고    scopus 로고
    • Bimodal action of menthol on the transient receptor potential channel TRPA1
    • Y. Karashima, N. Damann, and J. Prenen Bimodal action of menthol on the transient receptor potential channel TRPA1 J Neurosci 27 2007 9874 9884
    • (2007) J Neurosci , vol.27 , pp. 9874-9884
    • Karashima, Y.1    Damann, N.2    Prenen, J.3
  • 165
    • 55749087512 scopus 로고    scopus 로고
    • Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels
    • B. Xiao, A.E. Dubin, B. Bursulaya, V. Viswanath, T.J. Jegla, and A. Patapoutian Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels J Neurosci 28 2008 9640 9651
    • (2008) J Neurosci , vol.28 , pp. 9640-9651
    • Xiao, B.1    Dubin, A.E.2    Bursulaya, B.3    Viswanath, V.4    Jegla, T.J.5    Patapoutian, A.6
  • 167
    • 84855936838 scopus 로고    scopus 로고
    • Menthol pain relief through cumulative inactivation of voltage-gated sodium channels
    • C. Gaudioso, J. Hao, M.F. Martin-Eauclaire, M. Gabriac, and P. Delmas Menthol pain relief through cumulative inactivation of voltage-gated sodium channels Pain 153 2012 473 484
    • (2012) Pain , vol.153 , pp. 473-484
    • Gaudioso, C.1    Hao, J.2    Martin-Eauclaire, M.F.3    Gabriac, M.4    Delmas, P.5
  • 168
    • 0023192478 scopus 로고
    • Effect of menthol on two types of Ca currents in cultured sensory neurons of vertebrates
    • D. Swandulla, E. Carbone, K. Schafer, and H.D. Lux Effect of menthol on two types of Ca currents in cultured sensory neurons of vertebrates Pflugers Arch 409 1987 52 59
    • (1987) Pflugers Arch , vol.409 , pp. 52-59
    • Swandulla, D.1    Carbone, E.2    Schafer, K.3    Lux, H.D.4
  • 169
    • 33644769222 scopus 로고    scopus 로고
    • 2 +-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8
    • 2 +-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8 Neurosci Lett 397 2006 140 144
    • (2006) Neurosci Lett , vol.397 , pp. 140-144
    • Abe, J.1    Hosokawa, H.2    Sawada, Y.3    Matsumura, K.4    Kobayashi, S.5
  • 170
    • 59449084852 scopus 로고    scopus 로고
    • Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4,5-bisphosphate
    • R.L. Daniels, Y. Takashima, and D.D. McKemy Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4,5-bisphosphate J Biol Chem 284 2009 1570 1582
    • (2009) J Biol Chem , vol.284 , pp. 1570-1582
    • Daniels, R.L.1    Takashima, Y.2    McKemy, D.D.3
  • 171
    • 30544438062 scopus 로고    scopus 로고
    • Downregulation of transient receptor potential melastatin 8 by protein kinase C-mediated dephosphorylation
    • L.S. Premkumar, M. Raisinghani, S.C. Pingle, C. Long, and F. Pimentel Downregulation of transient receptor potential melastatin 8 by protein kinase C-mediated dephosphorylation J Neurosci 25 2005 11322 11329
    • (2005) J Neurosci , vol.25 , pp. 11322-11329
    • Premkumar, L.S.1    Raisinghani, M.2    Pingle, S.C.3    Long, C.4    Pimentel, F.5
  • 172
    • 83455234830 scopus 로고    scopus 로고
    • Decrease in phosphatidylinositol 4,5-bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels
    • Y. Yudin, V. Lukacs, C. Cao, and T. Rohacs Decrease in phosphatidylinositol 4,5-bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels J Physiol 589 2011 6007 6027
    • (2011) J Physiol , vol.589 , pp. 6007-6027
    • Yudin, Y.1    Lukacs, V.2    Cao, C.3    Rohacs, T.4
  • 173
    • 77951217290 scopus 로고    scopus 로고
    • The transient receptor potential channel TRPM8 is inhibited via the alpha 2A adrenoreceptor signaling pathway
    • A. Bavencoffe, D. Gkika, and A. Kondratskyi The transient receptor potential channel TRPM8 is inhibited via the alpha 2A adrenoreceptor signaling pathway J Biol Chem 285 2010 9410 9419
    • (2010) J Biol Chem , vol.285 , pp. 9410-9419
    • Bavencoffe, A.1    Gkika, D.2    Kondratskyi, A.3
  • 174
    • 34247523747 scopus 로고    scopus 로고
    • Regulation of transient receptor potential channels of melastatin type 8 (TRPM8): Effect of cAMP, cannabinoid CB(1) receptors and endovanilloids
    • L. De Petrocellis, K. Starowicz, A.S. Moriello, M. Vivese, P. Orlando, and V. Di Marzo Regulation of transient receptor potential channels of melastatin type 8 (TRPM8): effect of cAMP, cannabinoid CB(1) receptors and endovanilloids Exp Cell Res 313 2007 1911 1920
    • (2007) Exp Cell Res , vol.313 , pp. 1911-1920
    • De Petrocellis, L.1    Starowicz, K.2    Moriello, A.S.3    Vivese, M.4    Orlando, P.5    Di Marzo, V.6
  • 175
    • 33847633845 scopus 로고    scopus 로고
    • Desensitization of cold- and menthol-sensitive rat dorsal root ganglion neurones by inflammatory mediators
    • R.M. Linte, C. Ciobanu, G. Reid, and A. Babes Desensitization of cold- and menthol-sensitive rat dorsal root ganglion neurones by inflammatory mediators Exp Brain Res 178 2007 89 98
    • (2007) Exp Brain Res , vol.178 , pp. 89-98
    • Linte, R.M.1    Ciobanu, C.2    Reid, G.3    Babes, A.4
  • 176
    • 77955693167 scopus 로고    scopus 로고
    • Menthol response and adaptation in nociceptive-like and nonnociceptive-like neurons: Role of protein kinases
    • I. Sarria, and J. Gu Menthol response and adaptation in nociceptive-like and nonnociceptive-like neurons: role of protein kinases Mol Pain 6 2010 47
    • (2010) Mol Pain , vol.6 , pp. 47
    • Sarria, I.1    Gu, J.2
  • 177
    • 83055199978 scopus 로고    scopus 로고
    • TRPM8 acute desensitization is mediated by calmodulin and requires PIP(2): Distinction from tachyphylaxis
    • I. Sarria, J. Ling, M.X. Zhu, and J.G. Gu TRPM8 acute desensitization is mediated by calmodulin and requires PIP(2): distinction from tachyphylaxis J Neurophysiol 106 2011 3056 3066
    • (2011) J Neurophysiol , vol.106 , pp. 3056-3066
    • Sarria, I.1    Ling, J.2    Zhu, M.X.3    Gu, J.G.4
  • 178
    • 44249117614 scopus 로고    scopus 로고
    • Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8
    • L. De Petrocellis, V. Vellani, and A. Schiano-Moriello Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8 J Pharmacol Exp Ther 325 2008 1007 1015
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 1007-1015
    • De Petrocellis, L.1    Vellani, V.2    Schiano-Moriello, A.3
  • 179
    • 33947515995 scopus 로고    scopus 로고
    • Modulation of the cold-activated channel TRPM8 by lysophospholipids and polyunsaturated fatty acids
    • D.A. Andersson, M. Nash, and S. Bevan Modulation of the cold-activated channel TRPM8 by lysophospholipids and polyunsaturated fatty acids J Neurosci 27 2007 3347 3355
    • (2007) J Neurosci , vol.27 , pp. 3347-3355
    • Andersson, D.A.1    Nash, M.2    Bevan, S.3
  • 180
    • 33845979165 scopus 로고    scopus 로고
    • 2 +-independent phospholipase A2-dependent gating of TRPM8 by lysophospholipids
    • 2 +-independent phospholipase A2-dependent gating of TRPM8 by lysophospholipids J Biol Chem 281 2006 40174 40182
    • (2006) J Biol Chem , vol.281 , pp. 40174-40182
    • Vanden Abeele, F.1    Zholos, A.2    Bidaux, G.3
  • 181
    • 84876080671 scopus 로고    scopus 로고
    • Targeting TRPM8 for pain relief
    • C. Fernández-Peña, and F. Viana Targeting TRPM8 for pain relief Open Pain J 6 2013 154 164
    • (2013) Open Pain J , vol.6 , pp. 154-164
    • Fernández-Peña, C.1    Viana, F.2
  • 182
    • 67249087987 scopus 로고    scopus 로고
    • Review: Fibre, antispasmodics, and peppermint oil are all effective for irritable bowel syndrome
    • S.V. van Zanten Review: fibre, antispasmodics, and peppermint oil are all effective for irritable bowel syndrome Evid Based Med 14 2009 84
    • (2009) Evid Based Med , vol.14 , pp. 84
    • Van Zanten, S.V.1
  • 183
    • 80053184400 scopus 로고    scopus 로고
    • Human odontoblasts express functional thermo-sensitive TRP channels: Implications for dentin sensitivity
    • I.A. El Karim, G.J. Linden, and T.M. Curtis Human odontoblasts express functional thermo-sensitive TRP channels: implications for dentin sensitivity Pain 152 2011 2211 2223
    • (2011) Pain , vol.152 , pp. 2211-2223
    • El Karim, I.A.1    Linden, G.J.2    Curtis, T.M.3
  • 184
    • 79959721099 scopus 로고    scopus 로고
    • Genome-wide association study reveals three susceptibility loci for common migraine in the general population
    • D.I. Chasman, M. Schurks, and V. Anttila Genome-wide association study reveals three susceptibility loci for common migraine in the general population Nat Genet 43 2011 695 698
    • (2011) Nat Genet , vol.43 , pp. 695-698
    • Chasman, D.I.1    Schurks, M.2    Anttila, V.3
  • 185
    • 34447542435 scopus 로고    scopus 로고
    • The menthol receptor TRPM8 is the principal detector of environmental cold
    • D.M. Bautista, J. Siemens, and J.M. Glazer The menthol receptor TRPM8 is the principal detector of environmental cold Nature 448 2007 204 208
    • (2007) Nature , vol.448 , pp. 204-208
    • Bautista, D.M.1    Siemens, J.2    Glazer, J.M.3
  • 186
    • 34247472646 scopus 로고    scopus 로고
    • Attenuated cold sensitivity in TRPM8 null mice
    • R.W. Colburn, M.L. Lubin, and D.J. Stone Jr. Attenuated cold sensitivity in TRPM8 null mice Neuron 54 2007 379 386
    • (2007) Neuron , vol.54 , pp. 379-386
    • Colburn, R.W.1    Lubin, M.L.2    Stone, Jr.D.J.3
  • 188
    • 65649147153 scopus 로고    scopus 로고
    • + channels TRAAK and TREK-1 control both warm and cold perception
    • + channels TRAAK and TREK-1 control both warm and cold perception EMBO J 28 2009 1308 1318
    • (2009) EMBO J , vol.28 , pp. 1308-1318
    • Noel, J.1    Zimmermann, K.2    Busserolles, J.3
  • 189
    • 0345616438 scopus 로고    scopus 로고
    • ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
    • G.M. Story, A.M. Peier, and A.J. Reeve ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures Cell 112 2003 819 829
    • (2003) Cell , vol.112 , pp. 819-829
    • Story, G.M.1    Peier, A.M.2    Reeve, A.J.3
  • 190
    • 84860857225 scopus 로고    scopus 로고
    • Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation
    • N.R. Gavva, C. Davis, S.G. Lehto, S. Rao, W. Wang, and D.X. Zhu Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation Mol Pain 8 2012 36
    • (2012) Mol Pain , vol.8 , pp. 36
    • Gavva, N.R.1    Davis, C.2    Lehto, S.G.3    Rao, S.4    Wang, W.5    Zhu, D.X.6
  • 191
    • 54449099066 scopus 로고    scopus 로고
    • AMTB, a TRPM8 channel blocker: Evidence in rats for activity in overactive bladder and painful bladder syndrome
    • E.S. Lashinger, M.S. Steiginga, and J.P. Hieble AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome Am J Physiol Renal Physiol 295 2008 F803 F810
    • (2008) Am J Physiol Renal Physiol , vol.295 , pp. F803-F810
    • Lashinger, E.S.1    Steiginga, M.S.2    Hieble, J.P.3
  • 192
    • 33845222371 scopus 로고    scopus 로고
    • How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation
    • D.D. McKemy How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation Mol Pain 1 2005 16
    • (2005) Mol Pain , vol.1 , pp. 16
    • McKemy, D.D.1
  • 193
    • 0033548702 scopus 로고    scopus 로고
    • An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts
    • D. Jaquemar, T. Schenker, and B. Trueb An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts J Biol Chem 274 1999 7325 7333
    • (1999) J Biol Chem , vol.274 , pp. 7325-7333
    • Jaquemar, D.1    Schenker, T.2    Trueb, B.3
  • 194
    • 84868135050 scopus 로고    scopus 로고
    • TRPA1 is functionally expressed primarily by IB4-binding, non-peptidergic mouse and rat sensory neurons
    • M.E. Barabas, E.A. Kossyreva, and C.L. Stucky TRPA1 is functionally expressed primarily by IB4-binding, non-peptidergic mouse and rat sensory neurons PLoS One 7 2012 e47988
    • (2012) PLoS One , vol.7 , pp. e47988
    • Barabas, M.E.1    Kossyreva, E.A.2    Stucky, C.L.3
  • 195
    • 80053600154 scopus 로고    scopus 로고
    • TRPA1 and substance P mediate colitis in mice
    • M.A. Engel, A. Leffler, and F. Niedermirtl TRPA1 and substance P mediate colitis in mice Gastroenterology 141 2011 1346 1358
    • (2011) Gastroenterology , vol.141 , pp. 1346-1358
    • Engel, M.A.1    Leffler, A.2    Niedermirtl, F.3
  • 196
    • 84902343834 scopus 로고    scopus 로고
    • TRPA1 mediates bladder hyperalgesia in a mouse model of cystitis
    • J.J. DeBerry, E.S. Schwartz, and B.M. Davis TRPA1 mediates bladder hyperalgesia in a mouse model of cystitis Pain 155 2014 1280 1287
    • (2014) Pain , vol.155 , pp. 1280-1287
    • Deberry, J.J.1    Schwartz, E.S.2    Davis, B.M.3
  • 197
    • 70349731732 scopus 로고    scopus 로고
    • Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin
    • R. Atoyan, D. Shander, and N.V. Botchkareva Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin J Invest Dermatol 129 2009 2312 2315
    • (2009) J Invest Dermatol , vol.129 , pp. 2312-2315
    • Atoyan, R.1    Shander, D.2    Botchkareva, N.V.3
  • 198
    • 77649263336 scopus 로고    scopus 로고
    • Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn
    • Y.S. Kim, J.Y. Son, and T.H. Kim Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn J Comp Neurol 518 2010 687 698
    • (2010) J Comp Neurol , vol.518 , pp. 687-698
    • Kim, Y.S.1    Son, J.Y.2    Kim, T.H.3
  • 199
    • 77953188578 scopus 로고    scopus 로고
    • TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord
    • D. Uta, H. Furue, and A.E. Pickering TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord Eur J Neurosci 31 2010 1960 1973
    • (2010) Eur J Neurosci , vol.31 , pp. 1960-1973
    • Uta, D.1    Furue, H.2    Pickering, A.E.3
  • 200
    • 84859901805 scopus 로고    scopus 로고
    • The functions of TRPA1 and TRPV1: Moving away from sensory nerves
    • E.S. Fernandes, M.A. Fernandes, and J.E. Keeble The functions of TRPA1 and TRPV1: moving away from sensory nerves Br J Pharmacol. 166 2012 510 521
    • (2012) Br J Pharmacol. , vol.166 , pp. 510-521
    • Fernandes, E.S.1    Fernandes, M.A.2    Keeble, J.E.3
  • 201
    • 84555172978 scopus 로고    scopus 로고
    • TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3
    • E. Shigetomi, X. Tong, and K.Y. Kwan TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3 Nat Neurosci. 15 2011 70 80
    • (2011) Nat Neurosci. , vol.15 , pp. 70-80
    • Shigetomi, E.1    Tong, X.2    Kwan, K.Y.3
  • 202
    • 77955912196 scopus 로고    scopus 로고
    • Evidence for the pathophysiological relevance of TRPA1 receptors in the cardiovascular system in vivo
    • G. Pozsgai, J.V. Bodkin, and R. Graepel Evidence for the pathophysiological relevance of TRPA1 receptors in the cardiovascular system in vivo Cardiovasc Res. 87 2010 760 768
    • (2010) Cardiovasc Res. , vol.87 , pp. 760-768
    • Pozsgai, G.1    Bodkin, J.V.2    Graepel, R.3
  • 203
    • 84861669129 scopus 로고    scopus 로고
    • Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells
    • D.-S. Cao, L. Zhong, and Hsieh T-h Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells PLoS One 7 2012 e38005
    • (2012) PLoS One , vol.7 , pp. e38005
    • Cao, D.-S.1    Zhong, L.2
  • 204
    • 10644290199 scopus 로고    scopus 로고
    • TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells
    • D.P. Corey, J. Garcia-Anoveros, and J.R. Holt TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells Nature 432 2004 723 730
    • (2004) Nature , vol.432 , pp. 723-730
    • Corey, D.P.1    Garcia-Anoveros, J.2    Holt, J.R.3
  • 205
    • 81855221884 scopus 로고    scopus 로고
    • Tooth injury increases expression of the cold sensitive TRP channel TRPA1 in trigeminal neurons
    • E.T. Haas, K. Rowland, and M. Gautam Tooth injury increases expression of the cold sensitive TRP channel TRPA1 in trigeminal neurons Arch Oral Biol 56 2011 1604 1609
    • (2011) Arch Oral Biol , vol.56 , pp. 1604-1609
    • Haas, E.T.1    Rowland, K.2    Gautam, M.3
  • 206
    • 84865052691 scopus 로고    scopus 로고
    • Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation
    • R. Nassini, P. Pedretti, and N. Moretto Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation PLoS One. 7 2012 e42454
    • (2012) PLoS One. , vol.7 , pp. e42454
    • Nassini, R.1    Pedretti, P.2    Moretto, N.3
  • 207
    • 42349109026 scopus 로고    scopus 로고
    • A primer on ankyrin repeat function in TRP channels and beyond
    • R. Gaudet A primer on ankyrin repeat function in TRP channels and beyond Mol BioSyst 4 2008 372 379
    • (2008) Mol BioSyst , vol.4 , pp. 372-379
    • Gaudet, R.1
  • 208
    • 33845934490 scopus 로고    scopus 로고
    • Ankyrin repeat: A unique motif mediating protein-protein interactions
    • J. Li, A. Mahajan, and M.-D. Tsai Ankyrin repeat: a unique motif mediating protein-protein interactions Biochemistry 45 2006 15168 15178
    • (2006) Biochemistry , vol.45 , pp. 15168-15178
    • Li, J.1    Mahajan, A.2    Tsai, M.-D.3
  • 209
    • 79953156425 scopus 로고    scopus 로고
    • Irritating channels: The case of TRPA1
    • B. Nilius, J. Prenen, and G. Owsianik Irritating channels: the case of TRPA1 J Physiol 589 2011 1543 1549
    • (2011) J Physiol , vol.589 , pp. 1543-1549
    • Nilius, B.1    Prenen, J.2    Owsianik, G.3
  • 210
    • 84863178659 scopus 로고    scopus 로고
    • Identification of in vivo disulfide conformation of TRPA1 ion channel
    • L. Wang, T.L. Cvetkov, M.R. Chance, and V.Y. Moiseenkova-Bell Identification of in vivo disulfide conformation of TRPA1 ion channel J Biol Chem 287 2012 6169 6176
    • (2012) J Biol Chem , vol.287 , pp. 6169-6176
    • Wang, L.1    Cvetkov, T.L.2    Chance, M.R.3    Moiseenkova-Bell, V.Y.4
  • 211
    • 80055073153 scopus 로고    scopus 로고
    • Molecular architecture and subunit organization of TRPA1 ion channel revealed by electron microscopy
    • T.L. Cvetkov, K.W. Huynh, M.R. Cohen, and V.Y. Moiseenkova-Bell Molecular architecture and subunit organization of TRPA1 ion channel revealed by electron microscopy J Biol Chem 286 2011 38168 38176
    • (2011) J Biol Chem , vol.286 , pp. 38168-38176
    • Cvetkov, T.L.1    Huynh, K.W.2    Cohen, M.R.3    Moiseenkova-Bell, V.Y.4
  • 212
    • 33846692923 scopus 로고    scopus 로고
    • Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
    • L.J. Macpherson, A.E. Dubin, and M.J. Evans Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines Nature 445 2007 541 545
    • (2007) Nature , vol.445 , pp. 541-545
    • Macpherson, L.J.1    Dubin, A.E.2    Evans, M.J.3
  • 215
    • 55749115431 scopus 로고    scopus 로고
    • Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators
    • N. Takahashi, Y. Mizuno, and D. Kozai Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators Channels 2 2008 287 298
    • (2008) Channels , vol.2 , pp. 287-298
    • Takahashi, N.1    Mizuno, Y.2    Kozai, D.3
  • 216
    • 84864287703 scopus 로고    scopus 로고
    • The role of transient receptor potential ankyrin 1 (TRPA1) receptor activation in hydrogen-sulphide-induced CGRP-release and vasodilation
    • G. Pozsgai, Z. Hajna, and T. Bagoly The role of transient receptor potential ankyrin 1 (TRPA1) receptor activation in hydrogen-sulphide-induced CGRP-release and vasodilation Eur J Pharmacol 689 2012 56 64
    • (2012) Eur J Pharmacol , vol.689 , pp. 56-64
    • Pozsgai, G.1    Hajna, Z.2    Bagoly, T.3
  • 217
    • 34548094044 scopus 로고    scopus 로고
    • 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
    • M. Trevisani, J. Siemens, and S. Materazzi 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1 Proc Natl Acad Sci USA 104 2007 13519 13524
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 13519-13524
    • Trevisani, M.1    Siemens, J.2    Materazzi, S.3
  • 218
    • 84880072362 scopus 로고    scopus 로고
    • The molecular basis for species-specific activation of human TRPA1 protein by protons involves poorly conserved residues within transmembrane domains 5 and 6
    • J. de la Roche, M.J. Eberhardt, and A.B. Klinger The molecular basis for species-specific activation of human TRPA1 protein by protons involves poorly conserved residues within transmembrane domains 5 and 6 J Biol Chem 288 2013 20280 20292
    • (2013) J Biol Chem , vol.288 , pp. 20280-20292
    • De La Roche, J.1    Eberhardt, M.J.2    Klinger, A.B.3
  • 219
  • 220
    • 77957369610 scopus 로고    scopus 로고
    • TRPA1 is a component of the nociceptive response to CO2
    • Y.Y. Wang, R.B. Chang, and E.R. Liman TRPA1 is a component of the nociceptive response to CO2 J Neurosci 30 2010 12958 12963
    • (2010) J Neurosci , vol.30 , pp. 12958-12963
    • Wang, Y.Y.1    Chang, R.B.2    Liman, E.R.3
  • 222
    • 33646045075 scopus 로고    scopus 로고
    • TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents
    • D.M. Bautista, S.-E. Jordt, and T. Nikai TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents Cell 124 2006 1269 1282
    • (2006) Cell , vol.124 , pp. 1269-1282
    • Bautista, D.M.1    Jordt, S.-E.2    Nikai, T.3
  • 223
    • 84885145935 scopus 로고    scopus 로고
    • Species differences and molecular determinant of TRPA1 cold sensitivity
    • J. Chen, D. Kang, and J. Xu Species differences and molecular determinant of TRPA1 cold sensitivity Nat Commun 4 2013 2501
    • (2013) Nat Commun , vol.4 , pp. 2501
    • Chen, J.1    Kang, D.2    Xu, J.3
  • 225
    • 78049367698 scopus 로고    scopus 로고
    • The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors
    • M.J.M. Fischer, A. Leffler, and F. Niedermirtl The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors J Biol Chem 285 2010 34781 34792
    • (2010) J Biol Chem , vol.285 , pp. 34781-34792
    • Fischer, M.J.M.1    Leffler, A.2    Niedermirtl, F.3
  • 227
    • 58949092103 scopus 로고    scopus 로고
    • TRPA1 activation by lidocaine in nerve terminals results in glutamate release increase
    • L.-H. Piao, T. Fujita, and C.-Y. Jiang TRPA1 activation by lidocaine in nerve terminals results in glutamate release increase Biochem Biophys Res Commun 379 2009 980 984
    • (2009) Biochem Biophys Res Commun , vol.379 , pp. 980-984
    • Piao, L.-H.1    Fujita, T.2    Jiang, C.-Y.3
  • 228
    • 84862608453 scopus 로고    scopus 로고
    • Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner
    • T. Komatsu, K. Uchida, F. Fujita, Y. Zhou, and M. Tominaga Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner Pflugers Arch 463 2012 549 559
    • (2012) Pflugers Arch , vol.463 , pp. 549-559
    • Komatsu, T.1    Uchida, K.2    Fujita, F.3    Zhou, Y.4    Tominaga, M.5
  • 229
    • 70349559585 scopus 로고    scopus 로고
    • Nicotine activates the chemosensory cation channel TRPA1
    • K. Talavera, M. Gees, and Y. Karashima Nicotine activates the chemosensory cation channel TRPA1 Nat Neurosci 12 2009 1293 1299
    • (2009) Nat Neurosci , vol.12 , pp. 1293-1299
    • Talavera, K.1    Gees, M.2    Karashima, Y.3
  • 230
    • 84862534272 scopus 로고    scopus 로고
    • TRPA1 is a polyunsaturated fatty acid sensor in mammals
    • A.L. Motter, and G.P. Ahern TRPA1 is a polyunsaturated fatty acid sensor in mammals PLoS One 7 2012 e38439
    • (2012) PLoS One , vol.7 , pp. e38439
    • Motter, A.L.1    Ahern, G.P.2
  • 231
    • 77950927723 scopus 로고    scopus 로고
    • Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs
    • H. Hu, J. Tian, and Y. Zhu Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs Pflugers Arch 459 2010 579 592
    • (2010) Pflugers Arch , vol.459 , pp. 579-592
    • Hu, H.1    Tian, J.2    Zhu, Y.3
  • 232
    • 1842475312 scopus 로고    scopus 로고
    • Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
    • M. Bandell, G.M. Story, and S.W. Hwang Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin Neuron 41 2004 849 857
    • (2004) Neuron , vol.41 , pp. 849-857
    • Bandell, M.1    Story, G.M.2    Hwang, S.W.3
  • 233
    • 73749086232 scopus 로고    scopus 로고
    • Transient receptor potential channel A1 and noxious cold responses in rat cutaneous nociceptors
    • J. Dunham, J. Leith, B. Lumb, and D. LF Transient receptor potential channel A1 and noxious cold responses in rat cutaneous nociceptors Neuroscience 165 2010 1412 1419
    • (2010) Neuroscience , vol.165 , pp. 1412-1419
    • Dunham, J.1    Leith, J.2    Lumb, B.3    Lf, D.4
  • 235
    • 84901827531 scopus 로고    scopus 로고
    • Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six
    • S. Jabba, R. Goyal, and O. Sosa-Pagán Jason Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six Neuron 82 2014 1017 1031
    • (2014) Neuron , vol.82 , pp. 1017-1031
    • Jabba, S.1    Goyal, R.2    Sosa-Pagán Jason, O.3
  • 236
    • 79960369248 scopus 로고    scopus 로고
    • TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity
    • S.M. Brierley, J. Castro, and A.M. Harrington TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity J Physiol 589 2011 3575 3593
    • (2011) J Physiol , vol.589 , pp. 3575-3593
    • Brierley, S.M.1    Castro, J.2    Harrington, A.M.3
  • 237
    • 70749118691 scopus 로고    scopus 로고
    • The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli
    • e2083
    • S.M. Brierley, P.A. Hughes, and A.J. Page The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli Gastroenterology 137 2009 2084 2095 e2083
    • (2009) Gastroenterology , vol.137 , pp. 2084-2095
    • Brierley, S.M.1    Hughes, P.A.2    Page, A.J.3
  • 238
    • 57749107691 scopus 로고    scopus 로고
    • The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions
    • Y.Y. Wang, R.B. Chang, H.N. Waters, D.D. McKemy, and E.R. Liman The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions J Biol Chem 283 2008 32691 32703
    • (2008) J Biol Chem , vol.283 , pp. 32691-32703
    • Wang, Y.Y.1    Chang, R.B.2    Waters, H.N.3    McKemy, D.D.4    Liman, E.R.5
  • 239
    • 52749099369 scopus 로고    scopus 로고
    • Inhibition of transient receptor potential A1 channel by phosphatidylinositol-4,5-bisphosphate
    • D. Kim, E.J. Cavanaugh, and D. Simkin Inhibition of transient receptor potential A1 channel by phosphatidylinositol-4,5-bisphosphate Am J Physiol Cell Physiol 295 2008 C92 C99
    • (2008) Am J Physiol Cell Physiol , vol.295 , pp. C92-C99
    • Kim, D.1    Cavanaugh, E.J.2    Simkin, D.3
  • 240
    • 64849093208 scopus 로고    scopus 로고
    • TRPA1-mediated responses in trigeminal sensory neurons: Interaction between TRPA1 and TRPV1
    • M.M. Salas, K.M. Hargreaves, and A.N. Akopian TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1 Eur J Neurosci 29 2009 1568 1578
    • (2009) Eur J Neurosci , vol.29 , pp. 1568-1578
    • Salas, M.M.1    Hargreaves, K.M.2    Akopian, A.N.3
  • 241
    • 84860318535 scopus 로고    scopus 로고
    • 5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals
    • M. Sisignano, C.-K. Park, and C. Angioni 5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals J Neurosci 32 2012 6364 6372
    • (2012) J Neurosci , vol.32 , pp. 6364-6372
    • Sisignano, M.1    Park, C.-K.2    Angioni, C.3
  • 242
    • 84860207623 scopus 로고    scopus 로고
    • Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors
    • A.M. Gregus, S. Doolen, and D.S. Dumlao Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors Proc Natl Acad Sci USA 109 2012 6721 6726
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 6721-6726
    • Gregus, A.M.1    Doolen, S.2    Dumlao, D.S.3
  • 243
    • 33748188892 scopus 로고    scopus 로고
    • Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold
    • C.M. Elitt, S.L. McIlwrath, and J.J. Lawson Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold J Neurosci 26 2006 8578 8587
    • (2006) J Neurosci , vol.26 , pp. 8578-8587
    • Elitt, C.M.1    McIlwrath, S.L.2    Lawson, J.J.3
  • 244
    • 33646061333 scopus 로고    scopus 로고
    • TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction
    • K.Y. Kwan, A.J. Allchorne, and M.A. Vollrath TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction Neuron 50 2006 277 289
    • (2006) Neuron , vol.50 , pp. 277-289
    • Kwan, K.Y.1    Allchorne, A.J.2    Vollrath, M.A.3
  • 245
    • 0026749526 scopus 로고
    • Dynamic and static components of mechanical hyperalgesia in human hairy skin
    • M. Koltzenburg, L.E.R. Lundberg, and H.E. Torebjörk Dynamic and static components of mechanical hyperalgesia in human hairy skin Pain 51 1992 207 219
    • (1992) Pain , vol.51 , pp. 207-219
    • Koltzenburg, M.1    Lundberg, L.E.R.2    Torebjörk, H.E.3
  • 246
    • 84859964383 scopus 로고    scopus 로고
    • Species comparison and pharmacological characterization of human, monkey, rat, and mouse TRPA1 channels
    • B.R. Bianchi, X.-F. Zhang, R.M. Reilly, P.R. Kym, B.B. Yao, and J. Chen Species comparison and pharmacological characterization of human, monkey, rat, and mouse TRPA1 channels J Pharmacol Exp Ther 341 2012 360 368
    • (2012) J Pharmacol Exp Ther , vol.341 , pp. 360-368
    • Bianchi, B.R.1    Zhang, X.-F.2    Reilly, R.M.3    Kym, P.R.4    Yao, B.B.5    Chen, J.6
  • 247
    • 84882782663 scopus 로고    scopus 로고
    • TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis
    • B. Liu, J. Escalera, and S. Balakrishna TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis FASEB J 27 2013 3549 3563
    • (2013) FASEB J , vol.27 , pp. 3549-3563
    • Liu, B.1    Escalera, J.2    Balakrishna, S.3
  • 248
    • 84857922629 scopus 로고    scopus 로고
    • Activation of transient receptor potential ankyrin 1 evokes nociception through substance P release from primary sensory neurons
    • Y. Nakamura, Y. Une, and K. Miyano Activation of transient receptor potential ankyrin 1 evokes nociception through substance P release from primary sensory neurons J Neurochem 120 2012 1036 1047
    • (2012) J Neurochem , vol.120 , pp. 1036-1047
    • Nakamura, Y.1    Une, Y.2    Miyano, K.3
  • 249
    • 84877143340 scopus 로고    scopus 로고
    • Excitation and modulation of TRPA1, TRPV1, and TRPM8 channel-expressing sensory neurons by the pruritogen chloroquine
    • J.Y.-X.L. Than, L. Li, R. Hasan, and X. Zhang Excitation and modulation of TRPA1, TRPV1, and TRPM8 channel-expressing sensory neurons by the pruritogen chloroquine J Biol Chem 288 2013 12818 12827
    • (2013) J Biol Chem , vol.288 , pp. 12818-12827
    • Than, J.Y.-X.L.1    Li, L.2    Hasan, R.3    Zhang, X.4
  • 250
    • 84878331790 scopus 로고    scopus 로고
    • The ion channel TRPA1 is required for chronic itch
    • S.R. Wilson, A.M. Nelson, and L. Batia The ion channel TRPA1 is required for chronic itch J Neurosci 33 2013 9283 9294
    • (2013) J Neurosci , vol.33 , pp. 9283-9294
    • Wilson, S.R.1    Nelson, A.M.2    Batia, L.3
  • 251
    • 77953681608 scopus 로고    scopus 로고
    • A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome
    • B. Kremeyer, F. Lopera, and J.J. Cox A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome Neuron 66 2010 671 680
    • (2010) Neuron , vol.66 , pp. 671-680
    • Kremeyer, B.1    Lopera, F.2    Cox, J.J.3
  • 252
    • 84893824865 scopus 로고    scopus 로고
    • Differential methylation of the TRPA1 promoter in pain sensitivity
    • J.T. Bell, A.K. Loomis, and L.M. Butcher Differential methylation of the TRPA1 promoter in pain sensitivity Nat Commun 5 2014 2978
    • (2014) Nat Commun , vol.5 , pp. 2978
    • Bell, J.T.1    Loomis, A.K.2    Butcher, L.M.3
  • 253
    • 84884135043 scopus 로고    scopus 로고
    • Identification of a splice variant of mouse TRPA1 that regulates TRPA1 activity
    • Y. Zhou, Y. Suzuki, K. Uchida, and M. Tominaga Identification of a splice variant of mouse TRPA1 that regulates TRPA1 activity Nat Commun 4 2013 2399
    • (2013) Nat Commun , vol.4 , pp. 2399
    • Zhou, Y.1    Suzuki, Y.2    Uchida, K.3    Tominaga, M.4
  • 254
    • 84880043207 scopus 로고    scopus 로고
    • Emerging roles of TRPA1 in sensation of oxidative stress and its implications in defense and danger
    • S. Kim, and S. Hwang Emerging roles of TRPA1 in sensation of oxidative stress and its implications in defense and danger Arch Pharm Res 36 2013 783 791
    • (2013) Arch Pharm Res , vol.36 , pp. 783-791
    • Kim, S.1    Hwang, S.2
  • 255
    • 84857370967 scopus 로고    scopus 로고
    • Paclitaxel therapy potentiates cold hyperalgesia in streptozotocin-induced diabetic rats through enhanced mitochondrial reactive oxygen species production and TRPA1 sensitization
    • D.A. Barrière, J. Rieusset, and D. Chanteranne Paclitaxel therapy potentiates cold hyperalgesia in streptozotocin-induced diabetic rats through enhanced mitochondrial reactive oxygen species production and TRPA1 sensitization Pain 153 2012 553 561
    • (2012) Pain , vol.153 , pp. 553-561
    • Barrière, D.A.1    Rieusset, J.2    Chanteranne, D.3
  • 256
    • 79958744029 scopus 로고    scopus 로고
    • Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation
    • R. Nassini, M. Gees, and S. Harrison Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation Pain 152 2011 1621 1631
    • (2011) Pain , vol.152 , pp. 1621-1631
    • Nassini, R.1    Gees, M.2    Harrison, S.3
  • 257
    • 84899705648 scopus 로고    scopus 로고
    • Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain
    • E.A. Old, S. Nadkarni, and J. Grist Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain J Clin Invest 124 2014 2023 2036
    • (2014) J Clin Invest , vol.124 , pp. 2023-2036
    • Old, E.A.1    Nadkarni, S.2    Grist, J.3
  • 259
    • 84864609778 scopus 로고    scopus 로고
    • Activation of TRPA1 on dural afferents: A potential mechanism of headache pain
    • R.M. Edelmayer, L.N. Le, and J. Yan Activation of TRPA1 on dural afferents: a potential mechanism of headache pain Pain 153 2012 1949 1958
    • (2012) Pain , vol.153 , pp. 1949-1958
    • Edelmayer, R.M.1    Le, L.N.2    Yan, J.3
  • 260
    • 79953678388 scopus 로고    scopus 로고
    • A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis
    • E.S. Fernandes, F.A. Russell, and D. Spina A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis Arthritis Rheum 63 2011 819 829
    • (2011) Arthritis Rheum , vol.63 , pp. 819-829
    • Fernandes, E.S.1    Russell, F.A.2    Spina, D.3
  • 261
    • 45849101211 scopus 로고    scopus 로고
    • Transient receptor potential ankyrin-1 participates in visceral hyperalgesia following experimental colitis
    • J. Yang, Y. Li, X. Zuo, Y. Zhen, Y. Yu, and L. Gao Transient receptor potential ankyrin-1 participates in visceral hyperalgesia following experimental colitis Neurosci Lett 440 2008 237 241
    • (2008) Neurosci Lett , vol.440 , pp. 237-241
    • Yang, J.1    Li, Y.2    Zuo, X.3    Zhen, Y.4    Yu, Y.5    Gao, L.6
  • 262
    • 84890456531 scopus 로고    scopus 로고
    • Contribution of TRPA1 as a downstream signal of proteinase-activated receptor-2 to pancreatic pain
    • Y. Terada, M. Fujimura, and S. Nishimura Contribution of TRPA1 as a downstream signal of proteinase-activated receptor-2 to pancreatic pain J Pharmacol Sci 123 2013 284 287
    • (2013) J Pharmacol Sci , vol.123 , pp. 284-287
    • Terada, Y.1    Fujimura, M.2    Nishimura, S.3
  • 263
    • 82555196604 scopus 로고    scopus 로고
    • TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ9-tetrahydrocannabiorcol
    • D.A. Andersson, C. Gentry, and L. Alenmyr TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ9-tetrahydrocannabiorcol Nat Commun 2 2011 551
    • (2011) Nat Commun , vol.2 , pp. 551
    • Andersson, D.A.1    Gentry, C.2    Alenmyr, L.3
  • 264
    • 84892854661 scopus 로고    scopus 로고
    • TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins
    • V. Meseguer, Y.A. Alpizar, and E. Luis TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins Nat Commun 5 2014 3125
    • (2014) Nat Commun , vol.5 , pp. 3125
    • Meseguer, V.1    Alpizar, Y.A.2    Luis, E.3
  • 266
    • 56449110894 scopus 로고    scopus 로고
    • HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity
    • S. Eid, E. Crown, and E. Moore HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity Mol Pain 4 2008 48
    • (2008) Mol Pain , vol.4 , pp. 48
    • Eid, S.1    Crown, E.2    Moore, E.3
  • 267
    • 79954576919 scopus 로고    scopus 로고
    • Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
    • J. Chen, S.K. Joshi, and S. DiDomenico Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation Pain 152 2011 1165 1172
    • (2011) Pain , vol.152 , pp. 1165-1172
    • Chen, J.1    Joshi, S.K.2    Didomenico, S.3
  • 268
    • 38949175353 scopus 로고    scopus 로고
    • A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition
    • M. Petrus, A. Peier, and M. Bandell A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition Mol Pain 3 2007 40
    • (2007) Mol Pain , vol.3 , pp. 40
    • Petrus, M.1    Peier, A.2    Bandell, M.3
  • 269
    • 79960016324 scopus 로고    scopus 로고
    • TRPA1 ion channel in the spinal dorsal horn as a therapeutic target in central pain hypersensitivity and cutaneous neurogenic inflammation
    • A. Pertovaara, and A. Koivisto TRPA1 ion channel in the spinal dorsal horn as a therapeutic target in central pain hypersensitivity and cutaneous neurogenic inflammation Eur J Pharmacol 666 2011 1 4
    • (2011) Eur J Pharmacol , vol.666 , pp. 1-4
    • Pertovaara, A.1    Koivisto, A.2
  • 270
    • 84901270872 scopus 로고    scopus 로고
    • Transient receptor potential ankyrin 1 receptor activation in vitro and in vivo by pro-tussive agents: GRC 17536 as a promising anti-tussive therapeutic
    • I. Mukhopadhyay, A. Kulkarni, and S. Aranake Transient receptor potential ankyrin 1 receptor activation in vitro and in vivo by pro-tussive agents: GRC 17536 as a promising anti-tussive therapeutic PLoS One 9 2014 e97005
    • (2014) PLoS One , vol.9 , pp. e97005
    • Mukhopadhyay, I.1    Kulkarni, A.2    Aranake, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.