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Volumn 3, Issue 2, 2014, Pages 517-545

TRPV1: A potential drug target for treating various diseases

Author keywords

Cystitis; Diabetes; Obesity; Ototoxicity; Peripheral neuropathy; TRPV1

Indexed keywords

1 (2 BROMOPHENYL) 3 [1 (5 TRIFLUOROMETHYL 2 PYRIDINYL) 3 PYRROLIDINYL] UREA; 1 (2 BROMOPHENYL) 3 [1 (5 TRIFLUOROMETHYL 2 PYRIDINYL) 3 PYRROLIDINYL]UREA; 1 (5 ISOQUINOLINYL) 3 [4 (TRIFLUOROMETHYL) BENZYL] UREA; 1 (5 ISOQUINOLINYL) 3 [4 (TRIFLUOROMETHYL)BENZYL]UREA; 3 [2 (1 PIPERIDINYL) 6 (TRIFLUOROMETHYL) 3 PYRIDINYL] N (5, 6, 7, 8 TETRAHYDRO 7 HYDROXY 1 NAPHTHYL) ACRYLAMIDE; 3 [2 (1 PIPERIDINYL) 6 (TRIFLUOROMETHYL) 3 PYRIDINYL] N (5,6,7,8 TETRAHYDRO 7 HYDROXY 1 NAPHTHYL)ACRYLAMIDE; 4 CHLORO N (3 METHOXYPHENYL) CINNAMAMIDE; 4 CHLORO N (3 METHOXYPHENYL)CINNAMAMIDE; 4 [3 (TRIFLUOROMETHYL) 2 PYRIDINYL] N [5 (TRIFLUOROMETHYL) 2 PYRIDINYL] 1 PIPERAZINECARBOXAMIDE; ADENOSINE TRIPHOSPHATE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANANDAMIDE; BENZIMIDAZOLE; C REACTIVE PROTEIN; CAPSAICIN; CAPSAZEPINE; CISPLATIN; CITRIC ACID; ENDOCANNABINOID; GENTAMICIN; HEPOXILIN A; HEXAPEPTIDE; METHOCTRAMINE; N (1, 4 BENZODIOXAN 6 YL) 3 (4 TERT BUTYLPHENYL) ACRYLAMIDE; N (1,4 BENZODIOXAN 6 YL) 3 (4 TERT BUTYLPHENYL)ACRYLAMIDE; N OLEOYLETHANOLAMINE; N [4 [6 [4 (TRIFLUOROMETHYL) PHENYL] 4 PYRIMIDINYLOXY] BENZOTHIAZOL 2 YL] ACETAMIDE; N [4 [6 [4 (TRIFLUOROMETHYL)PHENYL] 4 PYRIMIDINYLOXY]BENZOTHIAZOL 2 YL]ACETAMIDE; QUINAZOLINE; REACTIVE OXYGEN METABOLITE; RESINIFERATOXIN; SPERMIDINE; STAT1 PROTEIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; UREA DERIVATIVE; VANILLOID RECEPTOR 1;

EID: 84907183896     PISSN: None     EISSN: 20734409     Source Type: Journal    
DOI: 10.3390/cells3020517     Document Type: Review
Times cited : (116)

References (194)
  • 1
    • 0034926291 scopus 로고    scopus 로고
    • The vanilloid receptor: A molecular gateway to the pain pathway
    • Caterina, M.J.; Julius, D. The vanilloid receptor: A molecular gateway to the pain pathway. Annu. Rev. Neurosci. 2001, 24, 487-517.
    • (2001) Annu. Rev. Neurosci. , vol.24 , pp. 487-517
    • Caterina, M.J.1    Julius, D.2
  • 2
    • 0025871477 scopus 로고
    • Capsaicin: Cellular targets, mechanisms of action, and selectivity for thin sensory neurons
    • Holzer, P. Capsaicin: Cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol. Rev. 1991, 43, 143-201.
    • (1991) Pharmacol. Rev. , vol.43 , pp. 143-201
    • Holzer, P.1
  • 4
    • 0034724402 scopus 로고    scopus 로고
    • Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human
    • Mezey, E.; Toth, Z.E.; Cortright, D.N.; Arzubi, M.K.; Krause, J.E.; Elde, R.; Guo, A.; Blumberg, P.M.; Szallasi, A. Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human. Proc. Natl. Acad. Sci. USA 2000, 97, 3655-3660.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 3655-3660
    • Mezey, E.1    Toth, Z.E.2    Cortright, D.N.3    Arzubi, M.K.4    Krause, J.E.5    Elde, R.6    Guo, A.7    Blumberg, P.M.8    Szallasi, A.9
  • 5
    • 0346221274 scopus 로고    scopus 로고
    • [3H]Resiniferatoxin autoradiography in the CNS of wild-type and TRPV1 null mice defines TRPV1 (VR-1) protein distribution
    • Roberts, J.C.; Davis, J.B.; Benham, C.D. [3H]Resiniferatoxin autoradiography in the CNS of wild-type and TRPV1 null mice defines TRPV1 (VR-1) protein distribution. Brain Res. 2004, 995, 176-183.
    • (2004) Brain Res. , vol.995 , pp. 176-183
    • Roberts, J.C.1    Davis, J.B.2    Benham, C.D.3
  • 6
    • 2442636258 scopus 로고    scopus 로고
    • Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels
    • Van der Stelt, M.; di Marzo, V. Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels. Eur. J. Biochem. 2004, 271, 1827-1834.
    • (2004) Eur. J. Biochem. , vol.271 , pp. 1827-1834
    • Van der Stelt, M.1    di Marzo, V.2
  • 8
    • 0344873175 scopus 로고    scopus 로고
    • Anandamide and vanilloid TRPV1 receptors
    • Ross, R.A. Anandamide and vanilloid TRPV1 receptors. Br. J. Pharmacol. 2003, 140, 790-801.
    • (2003) Br. J. Pharmacol. , vol.140 , pp. 790-801
    • Ross, R.A.1
  • 9
    • 0037308120 scopus 로고    scopus 로고
    • Endocannabinoids induce ileitis in rats via the capsaicin receptor (VR1)
    • McVey, D.C.; Schmid, P.C.; Schmid, H.H.; Vigna, S.R. Endocannabinoids induce ileitis in rats via the capsaicin receptor (VR1). J. Pharmacol. Exp. Ther. 2003, 304, 713-722.
    • (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 713-722
    • McVey, D.C.1    Schmid, P.C.2    Schmid, H.H.3    Vigna, S.R.4
  • 10
    • 0037341020 scopus 로고    scopus 로고
    • Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease
    • Lastres-Becker, I.; de Miguel, R.; de Petrocellis, L.; Makriyannis, A.; di Marzo, V.; Fernandez-Ruiz, J. Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease. J. Neurochem. 2003, 84, 1097-1109.
    • (2003) J. Neurochem. , vol.84 , pp. 1097-1109
    • Lastres-Becker, I.1    de Miguel, R.2    de Petrocellis, L.3    Makriyannis, A.4    di Marzo, V.5    Fernandez-Ruiz, J.6
  • 12
    • 39649088445 scopus 로고    scopus 로고
    • Actions of 3-methyl-N-oleoyldopamine, 4-methyl-N-oleoyldopamine and N-oleoylethanolamide on the rat TRPV1 receptor in vitro and in vivo
    • Almasi, R.; Szoke, E.; Bolcskei, K.; Varga, A.; Riedl, Z.; Sandor, Z.; Szolcsanyi, J.; Petho, G. Actions of 3-methyl-N-oleoyldopamine, 4-methyl-N-oleoyldopamine and N-oleoylethanolamide on the rat TRPV1 receptor in vitro and in vivo. Life Sci. 2008, 82, 644-651.
    • (2008) Life Sci. , vol.82 , pp. 644-651
    • Almasi, R.1    Szoke, E.2    Bolcskei, K.3    Varga, A.4    Riedl, Z.5    Sandor, Z.6    Szolcsanyi, J.7    Petho, G.8
  • 13
    • 17844392649 scopus 로고    scopus 로고
    • Oleoylethanolamide excites vagal sensory neurones, induces visceral pain and reduces short-term food intake in mice via capsaicin receptor TRPV1
    • Wang, X.; Miyares, R.L.; Ahern, G.P. Oleoylethanolamide excites vagal sensory neurones, induces visceral pain and reduces short-term food intake in mice via capsaicin receptor TRPV1. J. Physiol. 2005, 564, 541-547.
    • (2005) J. Physiol. , vol.564 , pp. 541-547
    • Wang, X.1    Miyares, R.L.2    Ahern, G.P.3
  • 14
    • 0038636006 scopus 로고    scopus 로고
    • Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat
    • Toth, A.; Kedei, N.; Wang, Y.; Blumberg, P.M. Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat. Life Sci. 2003, 73, 487-498.
    • (2003) Life Sci. , vol.73 , pp. 487-498
    • Toth, A.1    Kedei, N.2    Wang, Y.3    Blumberg, P.M.4
  • 18
    • 33747885659 scopus 로고    scopus 로고
    • Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: Their role and involvement in neurological disorders
    • Phillis, J.W.; Horrocks, L.A.; Farooqui, A.A. Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: Their role and involvement in neurological disorders. Brain Res. Rev. 2006, 52, 201-243.
    • (2006) Brain Res. Rev. , vol.52 , pp. 201-243
    • Phillis, J.W.1    Horrocks, L.A.2    Farooqui, A.A.3
  • 22
    • 84879845514 scopus 로고    scopus 로고
    • The role of endogenous molecules in modulating pain through transient receptor potential vanilloid 1 (TRPV1)
    • Morales-Lazaro, S.L.; Simon, S.A.; Rosenbaum, T. The role of endogenous molecules in modulating pain through transient receptor potential vanilloid 1 (TRPV1). J. Physiol. 2013, 591, 3109-3121.
    • (2013) J. Physiol. , vol.591 , pp. 3109-3121
    • Morales-Lazaro, S.L.1    Simon, S.A.2    Rosenbaum, T.3
  • 23
    • 66849104240 scopus 로고    scopus 로고
    • Pharmacology of vanilloid transient receptor potential cation channels
    • Vriens, J.; Appendino, G.; Nilius, B. Pharmacology of vanilloid transient receptor potential cation channels. Mol. Pharmacol. 2009, 75, 1262-1279.
    • (2009) Mol. Pharmacol. , vol.75 , pp. 1262-1279
    • Vriens, J.1    Appendino, G.2    Nilius, B.3
  • 24
    • 34250190946 scopus 로고    scopus 로고
    • The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity
    • Lishko, P.V.; Procko, E.; Jin, X.; Phelps, C.B.; Gaudet, R. The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity. Neuron 2007, 54, 905-918.
    • (2007) Neuron , vol.54 , pp. 905-918
    • Lishko, P.V.1    Procko, E.2    Jin, X.3    Phelps, C.B.4    Gaudet, R.5
  • 25
    • 0034700494 scopus 로고    scopus 로고
    • Induction of vanilloid receptor channel activity by protein kinase C
    • Premkumar, L.S.; Ahern, G.P. Induction of vanilloid receptor channel activity by protein kinase C. Nature 2000, 408, 985-990.
    • (2000) Nature , vol.408 , pp. 985-990
    • Premkumar, L.S.1    Ahern, G.P.2
  • 26
    • 0035810934 scopus 로고    scopus 로고
    • Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia
    • Tominaga, M.; Wada, M.; Masu, M. Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia. Proc. Natl. Acad. Sci. USA 2001, 98, 6951-6956.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6951-6956
    • Tominaga, M.1    Wada, M.2    Masu, M.3
  • 27
    • 0035855860 scopus 로고    scopus 로고
    • Molecular mechanisms of nociception
    • Julius, D.; Basbaum, A.I. Molecular mechanisms of nociception. Nature 2001, 413, 203-210.
    • (2001) Nature , vol.413 , pp. 203-210
    • Julius, D.1    Basbaum, A.I.2
  • 29
    • 33646845297 scopus 로고    scopus 로고
    • Polyamines are potent ligands for the capsaicin receptor TRPV1
    • Ahern, G.P.; Wang, X.; Miyares, R.L. Polyamines are potent ligands for the capsaicin receptor TRPV1. J. Biol. Chem. 2006, 281, 8991-8995.
    • (2006) J. Biol. Chem. , vol.281 , pp. 8991-8995
    • Ahern, G.P.1    Wang, X.2    Miyares, R.L.3
  • 30
    • 0017837049 scopus 로고
    • Comparison of responses of warm and nociceptive C-fiber afferents in monkey with human judgments of thermal pain
    • LaMotte, R.H.; Campbell, J.N. Comparison of responses of warm and nociceptive C-fiber afferents in monkey with human judgments of thermal pain. J. Neurophysiol. 1978, 41, 509-528.
    • (1978) J. Neurophysiol. , vol.41 , pp. 509-528
    • LaMotte, R.H.1    Campbell, J.N.2
  • 31
    • 0029047639 scopus 로고
    • Response of C fibre nociceptors in the anaesthetized monkey to heat stimuli: Estimates of receptor depth and threshold
    • Tillman, D.B.; Treede, R.D.; Meyer, R.A.; Campbell, J.N. Response of C fibre nociceptors in the anaesthetized monkey to heat stimuli: Estimates of receptor depth and threshold. J. Physiol. 1995, 485 Pt 3, 753-765.
    • (1995) J. Physiol. , vol.485 , Issue.PART 3 , pp. 753-765
    • Tillman, D.B.1    Treede, R.D.2    Meyer, R.A.3    Campbell, J.N.4
  • 32
    • 0030446311 scopus 로고    scopus 로고
    • A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin
    • Cesare, P.; McNaughton, P. A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin. Proc. Natl. Acad. Sci. USA 1996, 93, 15435-15439.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 15435-15439
    • Cesare, P.1    McNaughton, P.2
  • 33
    • 0030978813 scopus 로고    scopus 로고
    • Heat transduction in rat sensory neurons by calcium-dependent activation of a cation channel
    • Reichling, D.B.; Levine, J.D. Heat transduction in rat sensory neurons by calcium-dependent activation of a cation channel. Proc. Natl. Acad. Sci. USA 1997, 94, 7006-7011.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 7006-7011
    • Reichling, D.B.1    Levine, J.D.2
  • 35
    • 28844471303 scopus 로고    scopus 로고
    • Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors
    • Kobayashi, K.; Fukuoka, T.; Obata, K.; Yamanaka, H.; Dai, Y.; Tokunaga, A.; Noguchi, K. Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors. J. Comp. Neurol. 2005, 493, 596-606.
    • (2005) J. Comp. Neurol. , vol.493 , pp. 596-606
    • Kobayashi, K.1    Fukuoka, T.2    Obata, K.3    Yamanaka, H.4    Dai, Y.5    Tokunaga, A.6    Noguchi, K.7
  • 38
    • 84863727587 scopus 로고    scopus 로고
    • TRPV1 is important for mechanical and heat sensitivity in uninjured animals and development of heat hypersensitivity after muscle inflammation
    • Walder, R.Y.; Radhakrishnan, R.; Loo, L.; Rasmussen, L.A.; Mohapatra, D.P.; Wilson, S.P.; Sluka, K.A. TRPV1 is important for mechanical and heat sensitivity in uninjured animals and development of heat hypersensitivity after muscle inflammation. Pain 2012, 153, 1664-1672.
    • (2012) Pain , vol.153 , pp. 1664-1672
    • Walder, R.Y.1    Radhakrishnan, R.2    Loo, L.3    Rasmussen, L.A.4    Mohapatra, D.P.5    Wilson, S.P.6    Sluka, K.A.7
  • 39
    • 84886901532 scopus 로고    scopus 로고
    • Dynamic and permissive roles of TRPV1 and TRPV4 channels for thermosensation in mouse supraoptic magnocellular neurosecretory neurons
    • Sudbury, J.R.; Bourque, C.W. Dynamic and permissive roles of TRPV1 and TRPV4 channels for thermosensation in mouse supraoptic magnocellular neurosecretory neurons. J. Neurosci. 2013, 33, 17160-17165.
    • (2013) J. Neurosci. , vol.33 , pp. 17160-17165
    • Sudbury, J.R.1    Bourque, C.W.2
  • 40
    • 79954992058 scopus 로고    scopus 로고
    • Thermosensitive transient receptor potential channels in human corneal epithelial cells
    • Mergler, S.; Garreis, F.; Sahlmuller, M.; Reinach, P.S.; Paulsen, F.; Pleyer, U. Thermosensitive transient receptor potential channels in human corneal epithelial cells. J. Cell Physiol. 2011, 226, 1828-1842.
    • (2011) J. Cell Physiol. , vol.226 , pp. 1828-1842
    • Mergler, S.1    Garreis, F.2    Sahlmuller, M.3    Reinach, P.S.4    Paulsen, F.5    Pleyer, U.6
  • 41
    • 0030459626 scopus 로고    scopus 로고
    • Modification of nociceptor responses by inflammatory mediators and second messengers implicated in their action-A study in canine testicular polymodal receptors
    • Mizumura, K.; Kumazawa, T. Modification of nociceptor responses by inflammatory mediators and second messengers implicated in their action-A study in canine testicular polymodal receptors. Prog. Brain Res. 1996, 113, 115-141.
    • (1996) Prog. Brain Res. , vol.113 , pp. 115-141
    • Mizumura, K.1    Kumazawa, T.2
  • 43
    • 0034625770 scopus 로고    scopus 로고
    • Neuronal plasticity: Increasing the gain in pain
    • Woolf, C.J.; Salter, M.W. Neuronal plasticity: Increasing the gain in pain. Science 2000, 288, 1765-1769.
    • (2000) Science , vol.288 , pp. 1765-1769
    • Woolf, C.J.1    Salter, M.W.2
  • 44
  • 45
    • 2442468123 scopus 로고    scopus 로고
    • Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain
    • Dai, Y.; Moriyama, T.; Higashi, T.; Togashi, K.; Kobayashi, K.; Yamanaka, H.; Tominaga, M.; Noguchi, K. Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. J. Neurosci. 2004, 24, 4293-4299.
    • (2004) J. Neurosci. , vol.24 , pp. 4293-4299
    • Dai, Y.1    Moriyama, T.2    Higashi, T.3    Togashi, K.4    Kobayashi, K.5    Yamanaka, H.6    Tominaga, M.7    Noguchi, K.8
  • 47
    • 0038573980 scopus 로고    scopus 로고
    • Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity
    • Moriyama, T.; Iida, T.; Kobayashi, K.; Higashi, T.; Fukuoka, T.; Tsumura, H.; Leon, C.; Suzuki, N.; Inoue, K.; Gachet, C.; et al. Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity. J. Neurosci. 2003, 23, 6058-6062.
    • (2003) J. Neurosci. , vol.23 , pp. 6058-6062
    • Moriyama, T.1    Iida, T.2    Kobayashi, K.3    Higashi, T.4    Fukuoka, T.5    Tsumura, H.6    Leon, C.7    Suzuki, N.8    Inoue, K.9    Gachet, C.10
  • 48
    • 0036310523 scopus 로고    scopus 로고
    • Bradykinin lowers the threshold temperature for heat activation of vanilloid receptor 1
    • Sugiura, T.; Tominaga, M.; Katsuya, H.; Mizumura, K. Bradykinin lowers the threshold temperature for heat activation of vanilloid receptor 1. J. Neurophysiol. 2002, 88, 544-548.
    • (2002) J. Neurophysiol. , vol.88 , pp. 544-548
    • Sugiura, T.1    Tominaga, M.2    Katsuya, H.3    Mizumura, K.4
  • 49
    • 0142059776 scopus 로고    scopus 로고
    • Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)
    • Bhave, G.; Hu, H.J.; Glauner, K.S.; Zhu, W.; Wang, H.; Brasier, D.J.; Oxford, G.S.; Gereau, R.W.T. Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proc. Natl. Acad. Sci. USA 2003, 100, 12480-12485.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 12480-12485
    • Bhave, G.1    Hu, H.J.2    Glauner, K.S.3    Zhu, W.4    Wang, H.5    Brasier, D.J.6    Oxford, G.S.7    Gereau, R.W.T.8
  • 50
    • 0037134417 scopus 로고    scopus 로고
    • Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues
    • Numazaki, M.; Tominaga, T.; Toyooka, H.; Tominaga, M. Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues. J. Biol. Chem. 2002, 277, 13375-13378.
    • (2002) J. Biol. Chem. , vol.277 , pp. 13375-13378
    • Numazaki, M.1    Tominaga, T.2    Toyooka, H.3    Tominaga, M.4
  • 51
    • 84867624240 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 controls TRPV1 membrane trafficking and the heat sensitivity of nociceptors through KIF13B
    • Xing, B.M.; Yang, Y.R.; Du, J.X.; Chen, H.J.; Qi, C.; Huang, Z.H.; Zhang, Y.; Wang, Y. Cyclin-dependent kinase 5 controls TRPV1 membrane trafficking and the heat sensitivity of nociceptors through KIF13B. J. Neurosci. 2012, 32, 14709-14721.
    • (2012) J. Neurosci. , vol.32 , pp. 14709-14721
    • Xing, B.M.1    Yang, Y.R.2    Du, J.X.3    Chen, H.J.4    Qi, C.5    Huang, Z.H.6    Zhang, Y.7    Wang, Y.8
  • 52
    • 84863240877 scopus 로고    scopus 로고
    • Heteromeric heat-sensitive transient receptor potential channels exhibit distinct temperature and chemical response
    • Cheng, W.; Yang, F.; Liu, S.; Colton, C.K.; Wang, C.; Cui, Y.; Cao, X.; Zhu, M.X.; Sun, C.; Wang, K.; et al. Heteromeric heat-sensitive transient receptor potential channels exhibit distinct temperature and chemical response. J. Biol. Chem. 2012, 287, 7279-7288.
    • (2012) J. Biol. Chem. , vol.287 , pp. 7279-7288
    • Cheng, W.1    Yang, F.2    Liu, S.3    Colton, C.K.4    Wang, C.5    Cui, Y.6    Cao, X.7    Zhu, M.X.8    Sun, C.9    Wang, K.10
  • 53
    • 70349916098 scopus 로고    scopus 로고
    • Acid-sensitive ion channels and receptors
    • Holzer, P. Acid-sensitive ion channels and receptors. Handb. Exp. Pharmacol. 2009, 194, 283-332.
    • (2009) Handb. Exp. Pharmacol. , vol.194 , pp. 283-332
    • Holzer, P.1
  • 55
    • 33645894707 scopus 로고    scopus 로고
    • The role of the capsaicin receptor TRPV1 and acid-sensing ion channels (ASICS) in proton sensitivity of subpopulations of primary nociceptive neurons in rats and mice
    • Leffler, A.; Monter, B.; Koltzenburg, M. The role of the capsaicin receptor TRPV1 and acid-sensing ion channels (ASICS) in proton sensitivity of subpopulations of primary nociceptive neurons in rats and mice. Neuroscience 2006, 139, 699-709.
    • (2006) Neuroscience , vol.139 , pp. 699-709
    • Leffler, A.1    Monter, B.2    Koltzenburg, M.3
  • 57
    • 33748362837 scopus 로고    scopus 로고
    • Sustained currents through ASIC3 ion channels at the modest pH changes that occur during myocardial ischemia
    • Yagi, J.; Wenk, H.N.; Naves, L.A.; McCleskey, E.W. Sustained currents through ASIC3 ion channels at the modest pH changes that occur during myocardial ischemia. Circ. Res. 2006, 99, 501-509.
    • (2006) Circ. Res. , vol.99 , pp. 501-509
    • Yagi, J.1    Wenk, H.N.2    Naves, L.A.3    McCleskey, E.W.4
  • 58
    • 24644470357 scopus 로고    scopus 로고
    • Functional aspects and mechanisms of TRPV1 involvement in neurogenic inflammation that leads to thermal hyperalgesia
    • Planells-Cases, R.; Garcia-Sanz, N.; Morenilla-Palao, C.; Ferrer-Montiel, A. Functional aspects and mechanisms of TRPV1 involvement in neurogenic inflammation that leads to thermal hyperalgesia. Pflugers Arch. 2005, 451, 151-159.
    • (2005) Pflugers Arch. , vol.451 , pp. 151-159
    • Planells-Cases, R.1    Garcia-Sanz, N.2    Morenilla-Palao, C.3    Ferrer-Montiel, A.4
  • 59
    • 0034954583 scopus 로고    scopus 로고
    • VR1 protein expression increases in undamaged DRG neurons after partial nerve injury
    • Hudson, L.J.; Bevan, S.; Wotherspoon, G.; Gentry, C.; Fox, A.; Winter, J. VR1 protein expression increases in undamaged DRG neurons after partial nerve injury. Eur. J. Neurosci. 2001, 13, 2105-2114.
    • (2001) Eur. J. Neurosci. , vol.13 , pp. 2105-2114
    • Hudson, L.J.1    Bevan, S.2    Wotherspoon, G.3    Gentry, C.4    Fox, A.5    Winter, J.6
  • 60
    • 0037179755 scopus 로고    scopus 로고
    • p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
    • Ji, R.R.; Samad, T.A.; Jin, S.X.; Schmoll, R.; Woolf, C.J. p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron 2002, 36, 57-68.
    • (2002) Neuron , vol.36 , pp. 57-68
    • Ji, R.R.1    Samad, T.A.2    Jin, S.X.3    Schmoll, R.4    Woolf, C.J.5
  • 61
    • 0027908753 scopus 로고
    • Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
    • Tisch, R.; Yang, X.D.; Singer, S.M.; Liblau, R.S.; Fugger, L.; McDevitt, H.O. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 1993, 366, 72-75.
    • (1993) Nature , vol.366 , pp. 72-75
    • Tisch, R.1    Yang, X.D.2    Singer, S.M.3    Liblau, R.S.4    Fugger, L.5    McDevitt, H.O.6
  • 62
    • 0034010247 scopus 로고    scopus 로고
    • Genetic and immunological basis of autoimmune diabetes in the NOD mouse
    • Yoshida, K.; Kikutani, H. Genetic and immunological basis of autoimmune diabetes in the NOD mouse. Rev. Immunogenet. 2000, 2, 140-146.
    • (2000) Rev. Immunogenet. , vol.2 , pp. 140-146
    • Yoshida, K.1    Kikutani, H.2
  • 63
    • 0035865096 scopus 로고    scopus 로고
    • Type I diabetes and multiple sclerosis patients target islet plus central nervous system autoantigens; nonimmunized nonobese diabetic mice can develop autoimmune encephalitis
    • Winer, S.; Astsaturov, I.; Cheung, R.; Gunaratnam, L.; Kubiak, V.; Cortez, M.A.; Moscarello, M.; O'Connor, P.W.; McKerlie, C.; Becker, D.J.; et al. Type I diabetes and multiple sclerosis patients target islet plus central nervous system autoantigens; nonimmunized nonobese diabetic mice can develop autoimmune encephalitis. J. Immunol. 2001, 166, 2831-2841.
    • (2001) J. Immunol. , vol.166 , pp. 2831-2841
    • Winer, S.1    Astsaturov, I.2    Cheung, R.3    Gunaratnam, L.4    Kubiak, V.5    Cortez, M.A.6    Moscarello, M.7    O'Connor, P.W.8    McKerlie, C.9    Becker, D.J.10
  • 65
    • 0017720392 scopus 로고
    • Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones
    • Jancso, G.; Kiraly, E.; Jancso-Gabor, A. Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones. Nature 1977, 270, 741-743.
    • (1977) Nature , vol.270 , pp. 741-743
    • Jancso, G.1    Kiraly, E.2    Jancso-Gabor, A.3
  • 67
    • 17044421275 scopus 로고    scopus 로고
    • Immunological role of neuronal receptor vanilloid receptor 1 expressed on dendritic cells
    • Basu, S.; Srivastava, P. Immunological role of neuronal receptor vanilloid receptor 1 expressed on dendritic cells. Proc. Natl. Acad. Sci. USA 2005, 102, 5120-5125.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 5120-5125
    • Basu, S.1    Srivastava, P.2
  • 68
    • 84876479898 scopus 로고    scopus 로고
    • Transient receptor potential vanilloid-2 mediates the effects of transient heat shock on endocytosis of human monocyte-derived dendritic cells
    • Szollosi, A.G.; Olah, A.; Toth, I.B.; Papp, F.; Czifra, G.; Panyi, G.; Biro, T. Transient receptor potential vanilloid-2 mediates the effects of transient heat shock on endocytosis of human monocyte-derived dendritic cells. FEBS Lett. 2013, 587, 1440-1445.
    • (2013) FEBS Lett. , vol.587 , pp. 1440-1445
    • Szollosi, A.G.1    Olah, A.2    Toth, I.B.3    Papp, F.4    Czifra, G.5    Panyi, G.6    Biro, T.7
  • 69
    • 65549107329 scopus 로고    scopus 로고
    • Transient receptor potential vanilloid-1 signaling inhibits differentiation and activation of human dendritic cells
    • Toth, B.I.; Benko, S.; Szollosi, A.G.; Kovacs, L.; Rajnavolgyi, E.; Biro, T. Transient receptor potential vanilloid-1 signaling inhibits differentiation and activation of human dendritic cells. FEBS Lett. 2009, 583, 1619-1624.
    • (2009) FEBS Lett. , vol.583 , pp. 1619-1624
    • Toth, B.I.1    Benko, S.2    Szollosi, A.G.3    Kovacs, L.4    Rajnavolgyi, E.5    Biro, T.6
  • 70
    • 24944498502 scopus 로고    scopus 로고
    • Dendritic cells do not transduce inflammatory stimuli via the capsaicin receptor TRPV1
    • O'Connell, P.J.; Pingle, S.C.; Ahern, G.P. Dendritic cells do not transduce inflammatory stimuli via the capsaicin receptor TRPV1. FEBS Lett. 2005, 579, 5135-5139.
    • (2005) FEBS Lett. , vol.579 , pp. 5135-5139
    • O'Connell, P.J.1    Pingle, S.C.2    Ahern, G.P.3
  • 71
    • 3543040629 scopus 로고    scopus 로고
    • Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet beta cells modulates insulin secretion in rats
    • Akiba, Y.; Kato, S.; Katsube, K.; Nakamura, M.; Takeuchi, K.; Ishii, H.; Hibi, T. Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet beta cells modulates insulin secretion in rats. Biochem. Biophys. Res. Commun. 2004, 321, 219-225.
    • (2004) Biochem. Biophys. Res. Commun. , vol.321 , pp. 219-225
    • Akiba, Y.1    Kato, S.2    Katsube, K.3    Nakamura, M.4    Takeuchi, K.5    Ishii, H.6    Hibi, T.7
  • 73
    • 12844286900 scopus 로고    scopus 로고
    • Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1
    • Hong, S.; Wiley, J.W. Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1. J. Biol. Chem. 2005, 280, 618-627.
    • (2005) J. Biol. Chem. , vol.280 , pp. 618-627
    • Hong, S.1    Wiley, J.W.2
  • 75
    • 35348852604 scopus 로고    scopus 로고
    • Epidermal transient receptor potential vanilloid 1 in idiopathic small nerve fibre disease, diabetic neuropathy and healthy human subjects
    • Wilder-Smith, E.P.; Ong, W.Y.; Guo, Y.; Chow, A.W. Epidermal transient receptor potential vanilloid 1 in idiopathic small nerve fibre disease, diabetic neuropathy and healthy human subjects. Histopathology 2007, 51, 674-680.
    • (2007) Histopathology , vol.51 , pp. 674-680
    • Wilder-Smith, E.P.1    Ong, W.Y.2    Guo, Y.3    Chow, A.W.4
  • 76
    • 34250857978 scopus 로고    scopus 로고
    • Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy
    • Facer, P.; Casula, M.A.; Smith, G.D.; Benham, C.D.; Chessell, I.P.; Bountra, C.; Sinisi, M.; Birch, R.; Anand, P. Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy. BMC Neurol. 2007, 7, 11.
    • (2007) BMC Neurol. , vol.7 , pp. 11
    • Facer, P.1    Casula, M.A.2    Smith, G.D.3    Benham, C.D.4    Chessell, I.P.5    Bountra, C.6    Sinisi, M.7    Birch, R.8    Anand, P.9
  • 77
    • 0034604248 scopus 로고    scopus 로고
    • Chronic subclinical inflammation as part of the insulin resistance syndrome: The Insulin Resistance Atherosclerosis Study (IRAS)
    • Festa, A.; D'Agostino, R., Jr.; Howard, G.; Mykkanen, L.; Tracy, R.P.; Haffner, S.M. Chronic subclinical inflammation as part of the insulin resistance syndrome: The Insulin Resistance Atherosclerosis Study (IRAS). Circulation 2000, 102, 42-47.
    • (2000) Circulation , vol.102 , pp. 42-47
    • Festa, A.1    D'Agostino Jr., R.2    Howard, G.3    Mykkanen, L.4    Tracy, R.P.5    Haffner, S.M.6
  • 78
    • 0036140023 scopus 로고    scopus 로고
    • Associations of serum C-reactive protein with fasting insulin, glucose, and glycosylated hemoglobin: The Third National Health and Nutrition Examination Survey, 1988-1994
    • Wu, T.; Dorn, J.P.; Donahue, R.P.; Sempos, C.T.; Trevisan, M. Associations of serum C-reactive protein with fasting insulin, glucose, and glycosylated hemoglobin: The Third National Health and Nutrition Examination Survey, 1988-1994. Am. J. Epidemiol. 2002, 155, 65-71.
    • (2002) Am. J. Epidemiol. , vol.155 , pp. 65-71
    • Wu, T.1    Dorn, J.P.2    Donahue, R.P.3    Sempos, C.T.4    Trevisan, M.5
  • 79
    • 35348829384 scopus 로고    scopus 로고
    • Indicators for the efficacy of pioglitazone before and during treatment in Japanese patients with type 2 diabetes
    • Tajiri, Y.; Takei, R.; Mimura, K.; Umeda, F. Indicators for the efficacy of pioglitazone before and during treatment in Japanese patients with type 2 diabetes. Diabetes Technol. Ther. 2007, 9, 429-437.
    • (2007) Diabetes Technol. Ther. , vol.9 , pp. 429-437
    • Tajiri, Y.1    Takei, R.2    Mimura, K.3    Umeda, F.4
  • 80
    • 29644448140 scopus 로고    scopus 로고
    • Plasma calcitonin gene-related peptide is increased prior to obesity, and sensory nerve desensitization by capsaicin improves oral glucose tolerance in obese Zucker rats
    • Gram, D.X.; Hansen, A.J.; Wilken, M.; Elm, T.; Svendsen, O.; Carr, R.D.; Ahren, B.; Brand, C.L. Plasma calcitonin gene-related peptide is increased prior to obesity, and sensory nerve desensitization by capsaicin improves oral glucose tolerance in obese Zucker rats. Eur. J. Endocrinol. 2005, 153, 963-969.
    • (2005) Eur. J. Endocrinol. , vol.153 , pp. 963-969
    • Gram, D.X.1    Hansen, A.J.2    Wilken, M.3    Elm, T.4    Svendsen, O.5    Carr, R.D.6    Ahren, B.7    Brand, C.L.8
  • 81
    • 0029331457 scopus 로고
    • Resistance to aging-associated obesity in capsaicin-desensitized rats one year after treatment
    • Melnyk, A.; Himms-Hagen, J. Resistance to aging-associated obesity in capsaicin-desensitized rats one year after treatment. Obes. Res. 1995, 3, 337-344.
    • (1995) Obes. Res. , vol.3 , pp. 337-344
    • Melnyk, A.1    Himms-Hagen, J.2
  • 82
    • 0022501795 scopus 로고
    • Calcitonin gene-related peptide: Occurrence in pancreatic islets in the mouse and the rat and inhibition of insulin secretion in the mouse
    • Pettersson, M.; Ahren, B.; Bottcher, G.; Sundler, F. Calcitonin gene-related peptide: Occurrence in pancreatic islets in the mouse and the rat and inhibition of insulin secretion in the mouse. Endocrinology 1986, 119, 865-869.
    • (1986) Endocrinology , vol.119 , pp. 865-869
    • Pettersson, M.1    Ahren, B.2    Bottcher, G.3    Sundler, F.4
  • 83
    • 33846194056 scopus 로고    scopus 로고
    • Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes
    • Gram, D.X.; Ahren, B.; Nagy, I.; Olsen, U.B.; Brand, C.L.; Sundler, F.; Tabanera, R.; Svendsen, O.; Carr, R.D.; Santha, P.; et al. Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes. Eur. J. Neurosci. 2007, 25, 213-223.
    • (2007) Eur. J. Neurosci. , vol.25 , pp. 213-223
    • Gram, D.X.1    Ahren, B.2    Nagy, I.3    Olsen, U.B.4    Brand, C.L.5    Sundler, F.6    Tabanera, R.7    Svendsen, O.8    Carr, R.D.9    Santha, P.10
  • 84
    • 20044370154 scopus 로고    scopus 로고
    • Sensory and gastrointestinal satiety effects of capsaicin on food intake
    • Westerterp-Plantenga, M.S.; Smeets, A.; Lejeune, M.P. Sensory and gastrointestinal satiety effects of capsaicin on food intake. Int. J. Obes. 2005, 29, 682-688.
    • (2005) Int. J. Obes. , vol.29 , pp. 682-688
    • Westerterp-Plantenga, M.S.1    Smeets, A.2    Lejeune, M.P.3
  • 85
    • 33845765350 scopus 로고    scopus 로고
    • Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: A placebo-controlled, double-blind 8-week intervention in obese subjects
    • Belza, A.; Frandsen, E.; Kondrup, J. Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: A placebo-controlled, double-blind 8-week intervention in obese subjects. Int. J. Obes. 2007, 31, 121-130.
    • (2007) Int. J. Obes. , vol.31 , pp. 121-130
    • Belza, A.1    Frandsen, E.2    Kondrup, J.3
  • 87
    • 0032694345 scopus 로고    scopus 로고
    • Application of antioxidants and other agents to prevent cisplatin ototoxicity
    • Rybak, L.P.; Whitworth, C.; Somani, S. Application of antioxidants and other agents to prevent cisplatin ototoxicity. Laryngoscope 1999, 109, 1740-1744.
    • (1999) Laryngoscope , vol.109 , pp. 1740-1744
    • Rybak, L.P.1    Whitworth, C.2    Somani, S.3
  • 88
    • 12644293785 scopus 로고    scopus 로고
    • Use of organotypic cultures of Corti's organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory hair cells
    • Kopke, R.D.; Liu, W.; Gabaizadeh, R.; Jacono, A.; Feghali, J.; Spray, D.; Garcia, P.; Steinman, H.; Malgrange, B.; Ruben, R.J.; et al. Use of organotypic cultures of Corti's organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory hair cells. Am. J. Otol. 1997, 18, 559-571.
    • (1997) Am. J. Otol. , vol.18 , pp. 559-571
    • Kopke, R.D.1    Liu, W.2    Gabaizadeh, R.3    Jacono, A.4    Feghali, J.5    Spray, D.6    Garcia, P.7    Steinman, H.8    Malgrange, B.9    Ruben, R.J.10
  • 89
    • 0037486951 scopus 로고    scopus 로고
    • Vanilloid receptors in hearing: Altered cochlear sensitivity by vanilloids and expression of TRPV1 in the organ of corti
    • Zheng, J.; Dai, C.; Steyger, P.S.; Kim, Y.; Vass, Z.; Ren, T.; Nuttall, A.L. Vanilloid receptors in hearing: Altered cochlear sensitivity by vanilloids and expression of TRPV1 in the organ of corti. J. Neurophysiol. 2003, 90, 444-455.
    • (2003) J. Neurophysiol. , vol.90 , pp. 444-455
    • Zheng, J.1    Dai, C.2    Steyger, P.S.3    Kim, Y.4    Vass, Z.5    Ren, T.6    Nuttall, A.L.7
  • 90
    • 1542351164 scopus 로고    scopus 로고
    • Co-localization of the vanilloid capsaicin receptor and substance P in sensory nerve fibers innervating cochlear and vertebro-basilar arteries
    • Vass, Z.; Dai, C.F.; Steyger, P.S.; Jancso, G.; Trune, D.R.; Nuttall, A.L. Co-localization of the vanilloid capsaicin receptor and substance P in sensory nerve fibers innervating cochlear and vertebro-basilar arteries. Neuroscience 2004, 124, 919-927.
    • (2004) Neuroscience , vol.124 , pp. 919-927
    • Vass, Z.1    Dai, C.F.2    Steyger, P.S.3    Jancso, G.4    Trune, D.R.5    Nuttall, A.L.6
  • 91
    • 79751530452 scopus 로고    scopus 로고
    • Effect of capsaicin on potassium conductance and electromotility of the guinea pig outer hair cell
    • Wu, T.; Song, L.; Shi, X.; Jiang, Z.; Santos-Sacchi, J.; Nuttall, A.L. Effect of capsaicin on potassium conductance and electromotility of the guinea pig outer hair cell. Hear. Res. 2011, 272, 117-124.
    • (2011) Hear. Res. , vol.272 , pp. 117-124
    • Wu, T.1    Song, L.2    Shi, X.3    Jiang, Z.4    Santos-Sacchi, J.5    Nuttall, A.L.6
  • 92
    • 33746308434 scopus 로고    scopus 로고
    • Effect of intracochlear perfusion of vanilloids on cochlear neural activity in the guinea pig
    • Zhou, J.; Balaban, C.; Durrant, J.D. Effect of intracochlear perfusion of vanilloids on cochlear neural activity in the guinea pig. Hear. Res. 2006, 218, 43-49.
    • (2006) Hear. Res. , vol.218 , pp. 43-49
    • Zhou, J.1    Balaban, C.2    Durrant, J.D.3
  • 94
    • 19544392023 scopus 로고    scopus 로고
    • TRPV1 regulators mediate gentamicin penetration of cultured kidney cells
    • Myrdal, S.E.; Steyger, P.S. TRPV1 regulators mediate gentamicin penetration of cultured kidney cells. Hear. Res. 2005, 204, 170-182.
    • (2005) Hear. Res. , vol.204 , pp. 170-182
    • Myrdal, S.E.1    Steyger, P.S.2
  • 95
    • 84875973128 scopus 로고    scopus 로고
    • Different uptake of gentamicin through TRPV1 and TRPV4 channels determines cochlear hair cell vulnerability
    • Lee, J.H.; Park, C.; Kim, S.J.; Kim, H.J.; Oh, G.S.; Shen, A.; So, H.S.; Park, R. Different uptake of gentamicin through TRPV1 and TRPV4 channels determines cochlear hair cell vulnerability. Exp. Mol. Med. 2013, 45, e12.
    • (2013) Exp. Mol. Med. , vol.45
    • Lee, J.H.1    Park, C.2    Kim, S.J.3    Kim, H.J.4    Oh, G.S.5    Shen, A.6    So, H.S.7    Park, R.8
  • 96
    • 58149395091 scopus 로고    scopus 로고
    • Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat
    • Mukherjea, D.; Jajoo, S.; Whitworth, C.; Bunch, J.R.; Turner, J.G.; Rybak, L.P.; Ramkumar, V. Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat. J. Neurosci. 2008, 28, 13056-13065.
    • (2008) J. Neurosci. , vol.28 , pp. 13056-13065
    • Mukherjea, D.1    Jajoo, S.2    Whitworth, C.3    Bunch, J.R.4    Turner, J.G.5    Rybak, L.P.6    Ramkumar, V.7
  • 97
    • 79951870207 scopus 로고    scopus 로고
    • NOX3 NADPH oxidase couples transient receptor potential vanilloid 1 to signal transducer and activator of transcription 1-mediated inflammation and hearing loss
    • Mukherjea, D.; Jajoo, S.; Sheehan, K.; Kaur, T.; Sheth, S.; Bunch, J.; Perro, C.; Rybak, L.P.; Ramkumar, V. NOX3 NADPH oxidase couples transient receptor potential vanilloid 1 to signal transducer and activator of transcription 1-mediated inflammation and hearing loss. Antioxid Redox Signal. 2011, 14, 999-1010.
    • (2011) Antioxid Redox Signal. , vol.14 , pp. 999-1010
    • Mukherjea, D.1    Jajoo, S.2    Sheehan, K.3    Kaur, T.4    Sheth, S.5    Bunch, J.6    Perro, C.7    Rybak, L.P.8    Ramkumar, V.9
  • 98
    • 13844254271 scopus 로고    scopus 로고
    • Changes in transient receptor potential cation channel superfamily V (TRPV) mRNA expression in the mouse inner ear ganglia after kanamycin challenge
    • Kitahara, T.; Li, H.S.; Balaban, C.D. Changes in transient receptor potential cation channel superfamily V (TRPV) mRNA expression in the mouse inner ear ganglia after kanamycin challenge. Hear. Res. 2005, 201, 132-144.
    • (2005) Hear. Res. , vol.201 , pp. 132-144
    • Kitahara, T.1    Li, H.S.2    Balaban, C.D.3
  • 99
    • 60549094066 scopus 로고    scopus 로고
    • Changes in transient receptor potential vanilloid (TRPV) 1, 2, 3 and 4 expression in mouse inner ear following gentamicin challenge
    • Ishibashi, T.; Takumida, M.; Akagi, N.; Hirakawa, K.; Anniko, M. Changes in transient receptor potential vanilloid (TRPV) 1, 2, 3 and 4 expression in mouse inner ear following gentamicin challenge. Acta Oto-Laryngol. 2009, 129, 116-126.
    • (2009) Acta Oto-Laryngol. , vol.129 , pp. 116-126
    • Ishibashi, T.1    Takumida, M.2    Akagi, N.3    Hirakawa, K.4    Anniko, M.5
  • 101
    • 34447129412 scopus 로고    scopus 로고
    • Acoustic injury and TRPV1 expression in the cochlear spiral ganglion
    • Bauer, C.A.; Brozoski, T.J.; Myers, K.S. Acoustic injury and TRPV1 expression in the cochlear spiral ganglion. Int. Tinnitus J. 2007, 13, 21-28.
    • (2007) Int. Tinnitus J. , vol.13 , pp. 21-28
    • Bauer, C.A.1    Brozoski, T.J.2    Myers, K.S.3
  • 102
    • 80051492646 scopus 로고    scopus 로고
    • Short interfering RNA against STAT1 attenuates cisplatin-induced ototoxicity in the rat by suppressing inflammation
    • Kaur, T.; Mukherjea, D.; Sheehan, K.; Jajoo, S.; Rybak, L.P.; Ramkumar, V. Short interfering RNA against STAT1 attenuates cisplatin-induced ototoxicity in the rat by suppressing inflammation. Cell Death. Dis. 2011, 2, e180.
    • (2011) Cell Death. Dis. , vol.2
    • Kaur, T.1    Mukherjea, D.2    Sheehan, K.3    Jajoo, S.4    Rybak, L.P.5    Ramkumar, V.6
  • 103
    • 0035885406 scopus 로고    scopus 로고
    • Tachykinins as modulators of the micturition reflex in the central and peripheral nervous system
    • Lecci, A.; Maggi, C.A. Tachykinins as modulators of the micturition reflex in the central and peripheral nervous system. Regul. Pept. 2001, 101, 1-18.
    • (2001) Regul. Pept. , vol.101 , pp. 1-18
    • Lecci, A.1    Maggi, C.A.2
  • 104
    • 0035724244 scopus 로고    scopus 로고
    • Capsaicin receptor VR1 and ATP-gated ion channel P2X3 in human urinary bladder
    • Yiangou, Y.; Facer, P.; Ford, A.; Brady, C.; Wiseman, O.; Fowler, C.J.; Anand, P. Capsaicin receptor VR1 and ATP-gated ion channel P2X3 in human urinary bladder. BJU Int. 2001, 87, 774-779.
    • (2001) BJU Int. , vol.87 , pp. 774-779
    • Yiangou, Y.1    Facer, P.2    Ford, A.3    Brady, C.4    Wiseman, O.5    Fowler, C.J.6    Anand, P.7
  • 105
    • 0024324862 scopus 로고
    • Cystometric evidence that capsaicin-sensitive nerves modulate the afferent branch of micturition reflex in humans
    • Maggi, C.A.; Barbanti, G.; Santicioli, P.; Beneforti, P.; Misuri, D.; Meli, A.; Turini, D. Cystometric evidence that capsaicin-sensitive nerves modulate the afferent branch of micturition reflex in humans. J. Urol. 1989, 142, 150-154.
    • (1989) J. Urol. , vol.142 , pp. 150-154
    • Maggi, C.A.1    Barbanti, G.2    Santicioli, P.3    Beneforti, P.4    Misuri, D.5    Meli, A.6    Turini, D.7
  • 106
    • 0025116965 scopus 로고
    • The dual function of capsaicin-sensitive sensory nerves in the bladder and urethra
    • discussion 83-90
    • Maggi, C.A. The dual function of capsaicin-sensitive sensory nerves in the bladder and urethra. Ciba. Found. Symp. 1990, 151, 77-83; discussion 83-90.
    • (1990) Ciba. Found. Symp. , vol.151 , pp. 77-83
    • Maggi, C.A.1
  • 107
    • 0027411411 scopus 로고
    • Characterization of a peripheral vanilloid (capsaicin) receptor in the urinary bladder of the rat
    • Szallasi, A.; Conte, B.; Goso, C.; Blumberg, P.M.; Manzini, S. Characterization of a peripheral vanilloid (capsaicin) receptor in the urinary bladder of the rat. Life Sci. 1993, 52, PL221-PL226.
    • (1993) Life Sci. , vol.52
    • Szallasi, A.1    Conte, B.2    Goso, C.3    Blumberg, P.M.4    Manzini, S.5
  • 108
    • 0037154961 scopus 로고    scopus 로고
    • Vanilloid receptor 1 expression in the rat urinary tract
    • Avelino, A.; Cruz, C.; Nagy, I.; Cruz, F. Vanilloid receptor 1 expression in the rat urinary tract. Neuroscience 2002, 109, 787-798.
    • (2002) Neuroscience , vol.109 , pp. 787-798
    • Avelino, A.1    Cruz, C.2    Nagy, I.3    Cruz, F.4
  • 110
    • 13844294354 scopus 로고    scopus 로고
    • Capsaicin receptor TRPV1 in urothelium of neurogenic human bladders and effect of intravesical resiniferatoxin
    • Apostolidis, A.; Brady, C.M.; Yiangou, Y.; Davis, J.; Fowler, C.J.; Anand, P. Capsaicin receptor TRPV1 in urothelium of neurogenic human bladders and effect of intravesical resiniferatoxin. Urology 2005, 65, 400-405.
    • (2005) Urology , vol.65 , pp. 400-405
    • Apostolidis, A.1    Brady, C.M.2    Yiangou, Y.3    Davis, J.4    Fowler, C.J.5    Anand, P.6
  • 111
    • 70449339879 scopus 로고    scopus 로고
    • Sex differences in the expression profile of acid-sensing ion channels in the mouse urinary bladder: A possible involvement in irritative bladder symptoms
    • Kobayashi, H.; Yoshiyama, M.; Zakoji, H.; Takeda, M.; Araki, I. Sex differences in the expression profile of acid-sensing ion channels in the mouse urinary bladder: A possible involvement in irritative bladder symptoms. BJU Int. 2009, 104, 1746-1751.
    • (2009) BJU Int. , vol.104 , pp. 1746-1751
    • Kobayashi, H.1    Yoshiyama, M.2    Zakoji, H.3    Takeda, M.4    Araki, I.5
  • 112
    • 24644523380 scopus 로고    scopus 로고
    • Transient receptor potential vanilloid type 1 (TRPV1) expression changes from normal urothelium to transitional cell carcinoma of human bladder
    • Lazzeri, M.; Vannucchi, M.G.; Spinelli, M.; Bizzoco, E.; Beneforti, P.; Turini, D.; Faussone-Pellegrini, M.S. Transient receptor potential vanilloid type 1 (TRPV1) expression changes from normal urothelium to transitional cell carcinoma of human bladder. Eur. Urol. 2005, 48, 691-698.
    • (2005) Eur. Urol. , vol.48 , pp. 691-698
    • Lazzeri, M.1    Vannucchi, M.G.2    Spinelli, M.3    Bizzoco, E.4    Beneforti, P.5    Turini, D.6    Faussone-Pellegrini, M.S.7
  • 114
    • 78651304019 scopus 로고    scopus 로고
    • Expression and distribution of transient receptor potential (TRP) channels in bladder epithelium
    • Yu, W.; Hill, W.G.; Apodaca, G.; Zeidel, M.L. Expression and distribution of transient receptor potential (TRP) channels in bladder epithelium. Am. J. Physiol. Renal Physiol. 2011, 300, F49-F59.
    • (2011) Am. J. Physiol. Renal Physiol. , vol.300
    • Yu, W.1    Hill, W.G.2    Apodaca, G.3    Zeidel, M.L.4
  • 115
    • 0036279574 scopus 로고    scopus 로고
    • Topography of the vanilloid receptor in the human bladder: More than just the nerve fibers
    • Ost, D.; Roskams, T.; van der Aa, F.; de Ridder, D. Topography of the vanilloid receptor in the human bladder: More than just the nerve fibers. J. Urol. 2002, 168, 293-297.
    • (2002) J. Urol. , vol.168 , pp. 293-297
    • Ost, D.1    Roskams, T.2    van der Aa, F.3    de Ridder, D.4
  • 116
    • 0346498115 scopus 로고    scopus 로고
    • Electrical characteristics of suburothelial cells isolated from the human bladder
    • Sui, G.P.; Wu, C.; Fry, C.H. Electrical characteristics of suburothelial cells isolated from the human bladder. J. Urol. 2004, 171, 938-943.
    • (2004) J. Urol. , vol.171 , pp. 938-943
    • Sui, G.P.1    Wu, C.2    Fry, C.H.3
  • 118
    • 62649121036 scopus 로고    scopus 로고
    • Differential localizations of the transient receptor potential channels TRPV4 and TRPV1 in the mouse urinary bladder
    • Yamada, T.; Ugawa, S.; Ueda, T.; Ishida, Y.; Kajita, K.; Shimada, S. Differential localizations of the transient receptor potential channels TRPV4 and TRPV1 in the mouse urinary bladder. J. Histochem. Cytochem. 2009, 57, 277-287.
    • (2009) J. Histochem. Cytochem. , vol.57 , pp. 277-287
    • Yamada, T.1    Ugawa, S.2    Ueda, T.3    Ishida, Y.4    Kajita, K.5    Shimada, S.6
  • 119
    • 34548312495 scopus 로고    scopus 로고
    • Bladder afferent sensitivity in wild-type and TRPV1 knockout mice
    • Daly, D.; Rong, W.; Chess-Williams, R.; Chapple, C.; Grundy, D. Bladder afferent sensitivity in wild-type and TRPV1 knockout mice. J. Physiol. 2007, 583, 663-674.
    • (2007) J. Physiol. , vol.583 , pp. 663-674
    • Daly, D.1    Rong, W.2    Chess-Williams, R.3    Chapple, C.4    Grundy, D.5
  • 121
    • 0032871228 scopus 로고    scopus 로고
    • Effect of capsaicin on the micturition reflex in normal and chronic spinal cord-injured cats
    • Cheng, C.L.; Liu, J.C.; Chang, S.Y.; Ma, C.P.; de Groat, W.C. Effect of capsaicin on the micturition reflex in normal and chronic spinal cord-injured cats. Am. J. Physiol. 1999, 277, R786-R794.
    • (1999) Am. J. Physiol. , vol.277
    • Cheng, C.L.1    Liu, J.C.2    Chang, S.Y.3    Ma, C.P.4    de Groat, W.C.5
  • 122
    • 0028954338 scopus 로고
    • Effect of capsaicin on micturition and associated reflexes in chronic spinal rats
    • Cheng, C.L.; Ma, C.P.; de Groat, W.C. Effect of capsaicin on micturition and associated reflexes in chronic spinal rats. Brain Res. 1995, 678, 40-48.
    • (1995) Brain Res. , vol.678 , pp. 40-48
    • Cheng, C.L.1    Ma, C.P.2    de Groat, W.C.3
  • 123
    • 84855942949 scopus 로고    scopus 로고
    • Rat detrusor overactivity induced by chronic spinalization can be abolished by a transient receptor potential vanilloid 1 (TRPV1) antagonist
    • Santos-Silva, A.; Charrua, A.; Cruz, C.D.; Gharat, L.; Avelino, A.; Cruz, F. Rat detrusor overactivity induced by chronic spinalization can be abolished by a transient receptor potential vanilloid 1 (TRPV1) antagonist. Autono. Neurosci. 2012, 166, 35-38.
    • (2012) Autono. Neurosci. , vol.166 , pp. 35-38
    • Santos-Silva, A.1    Charrua, A.2    Cruz, C.D.3    Gharat, L.4    Avelino, A.5    Cruz, F.6
  • 124
    • 0032861506 scopus 로고    scopus 로고
    • Intravesical capsaicin and resiniferatoxin therapy: Spicing up the ways to treat the overactive bladder
    • Chancellor, M.B.; de Groat, W.C. Intravesical capsaicin and resiniferatoxin therapy: Spicing up the ways to treat the overactive bladder. J. Urol. 1999, 162, 3-11.
    • (1999) J. Urol. , vol.162 , pp. 3-11
    • Chancellor, M.B.1    de Groat, W.C.2
  • 125
    • 84870821092 scopus 로고    scopus 로고
    • Alteration in TRPV1 and Muscarinic (M3) receptor expression and function in idiopathic overactive bladder urothelial cells
    • Birder, L.A.; Wolf-Johnston, A.S.; Sun, Y.; Chai, T.C. Alteration in TRPV1 and Muscarinic (M3) receptor expression and function in idiopathic overactive bladder urothelial cells. Acta Physiol. (Oxf.) 2013, 207, 123-129.
    • (2013) Acta Physiol. (Oxf.) , vol.207 , pp. 123-129
    • Birder, L.A.1    Wolf-Johnston, A.S.2    Sun, Y.3    Chai, T.C.4
  • 126
    • 84891276546 scopus 로고    scopus 로고
    • Role of CXCR2 and TRPV1 in functional, inflammatory and behavioural changes in the rat model of cyclophosphamide-induced haemorrhagic cystitis
    • Dornelles, F.N.; Andrade, E.L.; Campos, M.M.; Calixto, J.B. Role of CXCR2 and TRPV1 in functional, inflammatory and behavioural changes in the rat model of cyclophosphamide-induced haemorrhagic cystitis. Br. J. Pharmacol. 2014, 171, 452-467.
    • (2014) Br. J. Pharmacol. , vol.171 , pp. 452-467
    • Dornelles, F.N.1    Andrade, E.L.2    Campos, M.M.3    Calixto, J.B.4
  • 127
    • 51549091407 scopus 로고    scopus 로고
    • Lack of TRPV1 inhibits cystitis-induced increased mechanical sensitivity in mice
    • Wang, Z.Y.; Wang, P.; Merriam, F.V.; Bjorling, D.E. Lack of TRPV1 inhibits cystitis-induced increased mechanical sensitivity in mice. Pain 2008, 139, 158-167.
    • (2008) Pain , vol.139 , pp. 158-167
    • Wang, Z.Y.1    Wang, P.2    Merriam, F.V.3    Bjorling, D.E.4
  • 128
    • 84880139912 scopus 로고    scopus 로고
    • Cyclophosphamide-induced cystitis reduces ASIC channel but enhances TRPV1 receptor function in rat bladder sensory neurons
    • Dang, K.; Bielefeldt, K.; Gebhart, G.F. Cyclophosphamide-induced cystitis reduces ASIC channel but enhances TRPV1 receptor function in rat bladder sensory neurons. J. Neurophysiol. 2013, 110, 408-417.
    • (2013) J. Neurophysiol. , vol.110 , pp. 408-417
    • Dang, K.1    Bielefeldt, K.2    Gebhart, G.F.3
  • 129
    • 84888638270 scopus 로고    scopus 로고
    • Increased mRNA expression of genes involved in pronociceptive inflammatory reactions in bladder tissue of interstitial cystitis
    • Homma, Y.; Nomiya, A.; Tagaya, M.; Oyama, T.; Takagaki, K.; Nishimatsu, H.; Igawa, Y. Increased mRNA expression of genes involved in pronociceptive inflammatory reactions in bladder tissue of interstitial cystitis. J. Urol. 2013, 190, 1925-1931.
    • (2013) J. Urol. , vol.190 , pp. 1925-1931
    • Homma, Y.1    Nomiya, A.2    Tagaya, M.3    Oyama, T.4    Takagaki, K.5    Nishimatsu, H.6    Igawa, Y.7
  • 130
    • 33746471163 scopus 로고    scopus 로고
    • Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system
    • Watanabe, N.; Horie, S.; Michael, G.J.; Keir, S.; Spina, D.; Page, C.P.; Priestley, J.V. Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system. Neuroscience 2006, 141, 1533-1543.
    • (2006) Neuroscience , vol.141 , pp. 1533-1543
    • Watanabe, N.1    Horie, S.2    Michael, G.J.3    Keir, S.4    Spina, D.5    Page, C.P.6    Priestley, J.V.7
  • 131
    • 84872121788 scopus 로고    scopus 로고
    • Quantitative analysis of TRP channel genes in mouse organs
    • Jang, Y.; Lee, Y.; Kim, S.M.; Yang, Y.D.; Jung, J.; Oh, U. Quantitative analysis of TRP channel genes in mouse organs. Arch. Pharm. Res. 2012, 35, 1823-1830.
    • (2012) Arch. Pharm. Res. , vol.35 , pp. 1823-1830
    • Jang, Y.1    Lee, Y.2    Kim, S.M.3    Yang, Y.D.4    Jung, J.5    Oh, U.6
  • 132
    • 33748136861 scopus 로고    scopus 로고
    • Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strains
    • Kunert-Keil, C.; Bisping, F.; Kruger, J.; Brinkmeier, H. Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strains. BMC Genomics 2006, 7, 159.
    • (2006) BMC Genomics , vol.7 , pp. 159
    • Kunert-Keil, C.1    Bisping, F.2    Kruger, J.3    Brinkmeier, H.4
  • 135
    • 77956235414 scopus 로고    scopus 로고
    • Loss of function of transient receptor potential vanilloid 1 (TRPV1) genetic variant is associated with lower risk of active childhood asthma
    • Cantero-Recasens, G.; Gonzalez, J.R.; Fandos, C.; Duran-Tauleria, E.; Smit, L.A.; Kauffmann, F.; Anto, J.M.; Valverde, M.A. Loss of function of transient receptor potential vanilloid 1 (TRPV1) genetic variant is associated with lower risk of active childhood asthma. J. Biol. Chem. 2010, 285, 27532-27535.
    • (2010) J. Biol. Chem. , vol.285 , pp. 27532-27535
    • Cantero-Recasens, G.1    Gonzalez, J.R.2    Fandos, C.3    Duran-Tauleria, E.4    Smit, L.A.5    Kauffmann, F.6    Anto, J.M.7    Valverde, M.A.8
  • 136
    • 34248146986 scopus 로고    scopus 로고
    • TRPV1 antagonists attenuate antigen-provoked cough in ovalbumin sensitized guinea pigs
    • McLeod, R.L.; Fernandez, X.; Correll, C.C.; Phelps, T.P.; Jia, Y.; Wang, X.; Hey, J.A. TRPV1 antagonists attenuate antigen-provoked cough in ovalbumin sensitized guinea pigs. Cough 2006, 2, 10.
    • (2006) Cough , vol.2 , pp. 10
    • McLeod, R.L.1    Fernandez, X.2    Correll, C.C.3    Phelps, T.P.4    Jia, Y.5    Wang, X.6    Hey, J.A.7
  • 138
    • 35548999215 scopus 로고    scopus 로고
    • Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs
    • Bhattacharya, A.; Scott, B.P.; Nasser, N.; Ao, H.; Maher, M.P.; Dubin, A.E.; Swanson, D.M.; Shankley, N.P.; Wickenden, A.D.; Chaplan, S.R. Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs. J. Pharmacol. Exp. Ther. 2007, 323, 665-674.
    • (2007) J. Pharmacol. Exp. Ther. , vol.323 , pp. 665-674
    • Bhattacharya, A.1    Scott, B.P.2    Nasser, N.3    Ao, H.4    Maher, M.P.5    Dubin, A.E.6    Swanson, D.M.7    Shankley, N.P.8    Wickenden, A.D.9    Chaplan, S.R.10
  • 139
    • 0028805448 scopus 로고
    • Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs
    • Lalloo, U.G.; Fox, A.J.; Belvisi, M.G.; Chung, K.F.; Barnes, P.J. Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs. J. Appl. Physiol. 1995, 79, 1082-1087.
    • (1995) J. Appl. Physiol. , vol.79 , pp. 1082-1087
    • Lalloo, U.G.1    Fox, A.J.2    Belvisi, M.G.3    Chung, K.F.4    Barnes, P.J.5
  • 140
    • 0033910751 scopus 로고    scopus 로고
    • Capsaicin responsiveness and cough in asthma and chronic obstructive pulmonary disease
    • Doherty, M.J.; Mister, R.; Pearson, M.G.; Calverley, P.M. Capsaicin responsiveness and cough in asthma and chronic obstructive pulmonary disease. Thorax 2000, 55, 643-649.
    • (2000) Thorax , vol.55 , pp. 643-649
    • Doherty, M.J.1    Mister, R.2    Pearson, M.G.3    Calverley, P.M.4
  • 141
    • 33745653533 scopus 로고    scopus 로고
    • Cough sensitivity in pure cough variant asthma elicited using continuous capsaicin inhalation
    • Nakajima, T.; Nishimura, Y.; Nishiuma, T.; Kotani, Y.; Nakata, H.; Yokoyama, M. Cough sensitivity in pure cough variant asthma elicited using continuous capsaicin inhalation. Allergol. Int. 2006, 55, 149-155.
    • (2006) Allergol. Int. , vol.55 , pp. 149-155
    • Nakajima, T.1    Nishimura, Y.2    Nishiuma, T.3    Kotani, Y.4    Nakata, H.5    Yokoyama, M.6
  • 142
    • 0029891760 scopus 로고    scopus 로고
    • Capsaicin cough sensitivity increases during upper respiratory infection
    • O'Connell, F.; Thomas, V.E.; Studham, J.M.; Pride, N.B.; Fuller, R.W. Capsaicin cough sensitivity increases during upper respiratory infection. Respir. Med. 1996, 90, 279-286.
    • (1996) Respir. Med. , vol.90 , pp. 279-286
    • O'Connell, F.1    Thomas, V.E.2    Studham, J.M.3    Pride, N.B.4    Fuller, R.W.5
  • 143
    • 64549160630 scopus 로고    scopus 로고
    • Cough reflex sensitivity testing in in seasonal allergic rhinitis patients and healthy volunteers
    • Pecova, R.; Zucha, J.; Pec, M.; Neuschlova, M.; Hanzel, P.; Tatar, M. Cough reflex sensitivity testing in in seasonal allergic rhinitis patients and healthy volunteers. J. Physiol. Pharmacol. 2008, 59(Suppl. 6), 557-564.
    • (2008) J. Physiol. Pharmacol. , vol.59 , Issue.SUPPL. 6 , pp. 557-564
    • Pecova, R.1    Zucha, J.2    Pec, M.3    Neuschlova, M.4    Hanzel, P.5    Tatar, M.6
  • 144
    • 33750412360 scopus 로고    scopus 로고
    • Testing of cough reflex sensitivity in children suffering from allergic rhinitis and common cold
    • Plevkova, J.; Varechova, S.; Brozmanova, M.; Tatar, M. Testing of cough reflex sensitivity in children suffering from allergic rhinitis and common cold. J. Physiol. Pharmacol. 2006, 57(Suppl. 4), 289-296.
    • (2006) J. Physiol. Pharmacol. , vol.57 , Issue.SUPPL. 4 , pp. 289-296
    • Plevkova, J.1    Varechova, S.2    Brozmanova, M.3    Tatar, M.4
  • 147
    • 0037090616 scopus 로고    scopus 로고
    • Expression of tachykinins in nonnociceptive vagal afferent neurons during respiratory viral infection in guinea pigs
    • Carr, M.J.; Hunter, D.D.; Jacoby, D.B.; Undem, B.J. Expression of tachykinins in nonnociceptive vagal afferent neurons during respiratory viral infection in guinea pigs. Am. J. Respir. Crit. Care Med. 2002, 165, 1071-1075.
    • (2002) Am. J. Respir. Crit. Care Med. , vol.165 , pp. 1071-1075
    • Carr, M.J.1    Hunter, D.D.2    Jacoby, D.B.3    Undem, B.J.4
  • 149
    • 84860519073 scopus 로고    scopus 로고
    • TRPV1 induction in airway vagal low-threshold mechanosensory neurons by allergen challenge and neurotrophic factors
    • Lieu, T.M.; Myers, A.C.; Meeker, S.; Undem, B.J. TRPV1 induction in airway vagal low-threshold mechanosensory neurons by allergen challenge and neurotrophic factors. Am. J. Physiol. Lung. Cell Mol. Physiol. 2012, 302, L941-L948.
    • (2012) Am. J. Physiol. Lung. Cell Mol. Physiol. , vol.302
    • Lieu, T.M.1    Myers, A.C.2    Meeker, S.3    Undem, B.J.4
  • 150
    • 0036082623 scopus 로고    scopus 로고
    • Allergic inflammation-induced neuropeptide production in rapidly adapting afferent nerves in guinea pig airways
    • Myers, A.C.; Kajekar, R.; Undem, B.J. Allergic inflammation-induced neuropeptide production in rapidly adapting afferent nerves in guinea pig airways. Am. J. Physiol. Lung Cell Mol. Physiol. 2002, 282, L775-L781.
    • (2002) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.282
    • Myers, A.C.1    Kajekar, R.2    Undem, B.J.3
  • 151
    • 79952964536 scopus 로고    scopus 로고
    • Cough reflex sensitivity is increased in guinea pigs with parainfluenza virus infection
    • Ye, X.M.; Zhong, N.S.; Liu, C.L.; Chen, R.C. Cough reflex sensitivity is increased in guinea pigs with parainfluenza virus infection. Exp. Lung Res. 2011, 37, 186-194.
    • (2011) Exp. Lung Res. , vol.37 , pp. 186-194
    • Ye, X.M.1    Zhong, N.S.2    Liu, C.L.3    Chen, R.C.4
  • 152
    • 57049165322 scopus 로고    scopus 로고
    • Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat
    • Zhang, G.; Lin, R.L.; Wiggers, M.; Snow, D.M.; Lee, L.Y. Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat. J. Physiol. 2008, 586, 5771-5786.
    • (2008) J. Physiol. , vol.586 , pp. 5771-5786
    • Zhang, G.1    Lin, R.L.2    Wiggers, M.3    Snow, D.M.4    Lee, L.Y.5
  • 153
    • 33947310739 scopus 로고    scopus 로고
    • Diabetic painful neuropathy: Current and future treatment options
    • Chong, M.S.; Hester, J. Diabetic painful neuropathy: Current and future treatment options. Drugs 2007, 67, 569-585.
    • (2007) Drugs , vol.67 , pp. 569-585
    • Chong, M.S.1    Hester, J.2
  • 154
    • 0035208068 scopus 로고    scopus 로고
    • Management of painful diabetic neuropathy
    • Jensen, P.G.; Larson, J.R. Management of painful diabetic neuropathy. Drugs Aging 2001, 18, 737-749.
    • (2001) Drugs Aging , vol.18 , pp. 737-749
    • Jensen, P.G.1    Larson, J.R.2
  • 155
    • 41949119381 scopus 로고    scopus 로고
    • An update on the pharmacological management of post-herpetic neuralgia and painful diabetic neuropathy
    • Zin, C.S.; Nissen, L.M.; Smith, M.T.; O'Callaghan, J.P.; Moore, B.J. An update on the pharmacological management of post-herpetic neuralgia and painful diabetic neuropathy. CNS Drugs 2008, 22, 417-442.
    • (2008) CNS Drugs , vol.22 , pp. 417-442
    • Zin, C.S.1    Nissen, L.M.2    Smith, M.T.3    O'Callaghan, J.P.4    Moore, B.J.5
  • 156
    • 34249718923 scopus 로고    scopus 로고
    • Management strategies for herpes zoster and postherpetic neuralgia
    • Galluzzi, K.E. Management strategies for herpes zoster and postherpetic neuralgia. J. Am. Osteopath. Assoc. 2007, 107, S8-S13.
    • (2007) J. Am. Osteopath. Assoc. , vol.107
    • Galluzzi, K.E.1
  • 157
    • 58149201564 scopus 로고    scopus 로고
    • Recent progress in the development of selective TRPV1 antagonists for pain
    • Broad, L.M.; Keding, S.J.; Blanco, M.J. Recent progress in the development of selective TRPV1 antagonists for pain. Curr. Top. Med. Chem. 2008, 8, 1431-1441.
    • (2008) Curr. Top. Med. Chem. , vol.8 , pp. 1431-1441
    • Broad, L.M.1    Keding, S.J.2    Blanco, M.J.3
  • 158
    • 65549133355 scopus 로고    scopus 로고
    • Vanilloid receptor antagonists: Emerging class of novel anti-inflammatory agents for pain management
    • Pal, M.; Angaru, S.; Kodimuthali, A.; Dhingra, N. Vanilloid receptor antagonists: Emerging class of novel anti-inflammatory agents for pain management. Curr. Pharm. Des. 2009, 15, 1008-1026.
    • (2009) Curr. Pharm. Des. , vol.15 , pp. 1008-1026
    • Pal, M.1    Angaru, S.2    Kodimuthali, A.3    Dhingra, N.4
  • 159
    • 63649126112 scopus 로고    scopus 로고
    • Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks
    • Wong, G.Y.; Gavva, N.R. Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks. Brain Res. Rev. 2009, 60, 267-277.
    • (2009) Brain Res. Rev. , vol.60 , pp. 267-277
    • Wong, G.Y.1    Gavva, N.R.2
  • 162
    • 0030792361 scopus 로고    scopus 로고
    • Capsazepine, a vanilloid receptor antagonist, inhibits nicotinic acetylcholine receptors in rat trigeminal ganglia
    • Liu, L.; Simon, S.A. Capsazepine, a vanilloid receptor antagonist, inhibits nicotinic acetylcholine receptors in rat trigeminal ganglia. Neurosci. Lett. 1997, 228, 29-32.
    • (1997) Neurosci. Lett. , vol.228 , pp. 29-32
    • Liu, L.1    Simon, S.A.2
  • 163
    • 0030742250 scopus 로고    scopus 로고
    • Capsazepine block of voltage-activated calcium channels in adult rat dorsal root ganglion neurones in culture
    • Docherty, R.J.; Yeats, J.C.; Piper, A.S. Capsazepine block of voltage-activated calcium channels in adult rat dorsal root ganglion neurones in culture. Br. J. Pharmacol. 1997, 121, 1461-1467.
    • (1997) Br. J. Pharmacol. , vol.121 , pp. 1461-1467
    • Docherty, R.J.1    Yeats, J.C.2    Piper, A.S.3
  • 164
    • 23044500197 scopus 로고    scopus 로고
    • Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8
    • Weil, A.; Moore, S.E.; Waite, N.J.; Randall, A.; Gunthorpe, M.J. Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8. Mol. Pharmacol. 2005, 68, 518-527.
    • (2005) Mol. Pharmacol. , vol.68 , pp. 518-527
    • Weil, A.1    Moore, S.E.2    Waite, N.J.3    Randall, A.4    Gunthorpe, M.J.5
  • 165
    • 0037215646 scopus 로고    scopus 로고
    • The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain
    • Walker, K.M.; Urban, L.; Medhurst, S.J.; Patel, S.; Panesar, M.; Fox, A.J.; McIntyre, P. The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain. J. Pharmacol. Exp. Ther. 2003, 304, 56-62.
    • (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 56-62
    • Walker, K.M.1    Urban, L.2    Medhurst, S.J.3    Patel, S.4    Panesar, M.5    Fox, A.J.6    McIntyre, P.7
  • 166
    • 34447632844 scopus 로고    scopus 로고
    • Alpha-substituted N-(4-tert-butylbenzyl)-N'-[4-(methylsulfonylamino) benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists
    • Chung, J.U.; Kim, S.Y.; Lim, J.O.; Choi, H.K.; Kang, S.U.; Yoon, H.S.; Ryu, H.; Kang, D.W.; Lee, J.; Kang, B.; et al. Alpha-substituted N-(4-tert-butylbenzyl)-N'-[4-(methylsulfonylamino) benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists. Bioorg. Med. Chem. 2007, 15, 6043-6053.
    • (2007) Bioorg. Med. Chem. , vol.15 , pp. 6043-6053
    • Chung, J.U.1    Kim, S.Y.2    Lim, J.O.3    Choi, H.K.4    Kang, S.U.5    Yoon, H.S.6    Ryu, H.7    Kang, D.W.8    Lee, J.9    Kang, B.10
  • 167
    • 24744433102 scopus 로고    scopus 로고
    • Novel potent antagonists of transient receptor potential channel, vanilloid subfamily member 1: Structure-activity relationship of 1,3-diarylalkyl thioureas possessing new vanilloid equivalents
    • Suh, Y.G.; Lee, Y.S.; Min, K.H.; Park, O.H.; Kim, J.K.; Seung, H.S.; Seo, S.Y.; Lee, B.Y.; Nam, Y.H.; Lee, K.O.; et al. Novel potent antagonists of transient receptor potential channel, vanilloid subfamily member 1: Structure-activity relationship of 1,3-diarylalkyl thioureas possessing new vanilloid equivalents. J. Med. Chem. 2005, 48, 5823-5836.
    • (2005) J. Med. Chem. , vol.48 , pp. 5823-5836
    • Suh, Y.G.1    Lee, Y.S.2    Min, K.H.3    Park, O.H.4    Kim, J.K.5    Seung, H.S.6    Seo, S.Y.7    Lee, B.Y.8    Nam, Y.H.9    Lee, K.O.10
  • 169
    • 34248138496 scopus 로고    scopus 로고
    • The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
    • Szallasi, A.; Cortright, D.N.; Blum, C.A.; Eid, S.R. The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat. Rev. Drug Discov. 2007, 6, 357-372.
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 357-372
    • Szallasi, A.1    Cortright, D.N.2    Blum, C.A.3    Eid, S.R.4
  • 171
    • 23044473189 scopus 로고    scopus 로고
    • A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid
    • El Kouhen, R.; Surowy, C.S.; Bianchi, B.R.; Neelands, T.R.; McDonald, H.A.; Niforatos, W.; Gomtsyan, A.; Lee, C.H.; Honore, P.; Sullivan, J.P.; et al. A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid. J. Pharmacol. Exp. Ther. 2005, 314, 400-409.
    • (2005) J. Pharmacol. Exp. Ther. , vol.314 , pp. 400-409
    • El Kouhen, R.1    Surowy, C.S.2    Bianchi, B.R.3    Neelands, T.R.4    McDonald, H.A.5    Niforatos, W.6    Gomtsyan, A.7    Lee, C.H.8    Honore, P.9    Sullivan, J.P.10
  • 172
    • 0038467306 scopus 로고    scopus 로고
    • N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl) tetrahydropyrazine-1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. In vitro characterization and pharmacokinetic properties
    • Valenzano, K.J.; Grant, E.R.; Wu, G.; Hachicha, M.; Schmid, L.; Tafesse, L.; Sun, Q.; Rotshteyn, Y.; Francis, J.; Limberis, J.; et al. N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl) tetrahydropyrazine-1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. In vitro characterization and pharmacokinetic properties. J. Pharmacol. Exp. Ther. 2003, 306, 377-386.
    • (2003) J. Pharmacol. Exp. Ther. , vol.306 , pp. 377-386
    • Valenzano, K.J.1    Grant, E.R.2    Wu, G.3    Hachicha, M.4    Schmid, L.5    Tafesse, L.6    Sun, Q.7    Rotshteyn, Y.8    Francis, J.9    Limberis, J.10
  • 173
    • 20144376596 scopus 로고    scopus 로고
    • Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl) amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist
    • Swanson, D.M.; Dubin, A.E.; Shah, C.; Nasser, N.; Chang, L.; Dax, S.L.; Jetter, M.; Breitenbucher, J.G.; Liu, C.; Mazur, C.; et al. Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl) amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist. J. Med. Chem. 2005, 48, 1857-1872.
    • (2005) J. Med. Chem. , vol.48 , pp. 1857-1872
    • Swanson, D.M.1    Dubin, A.E.2    Shah, C.3    Nasser, N.4    Chang, L.5    Dax, S.L.6    Jetter, M.7    Breitenbucher, J.G.8    Liu, C.9    Mazur, C.10
  • 176
    • 20144362216 scopus 로고    scopus 로고
    • AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo [b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties
    • Gavva, N.R.; Tamir, R.; Qu, Y.; Klionsky, L.; Zhang, T.J.; Immke, D.; Wang, J.; Zhu, D.; Vanderah, T.W.; Porreca, F.; et al. AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo [b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J. Pharmacol. Exp. Ther. 2005, 313, 474-484.
    • (2005) J. Pharmacol. Exp. Ther. , vol.313 , pp. 474-484
    • Gavva, N.R.1    Tamir, R.2    Qu, Y.3    Klionsky, L.4    Zhang, T.J.5    Immke, D.6    Wang, J.7    Zhu, D.8    Vanderah, T.W.9    Porreca, F.10
  • 178
    • 33745136758 scopus 로고    scopus 로고
    • Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles
    • Ognyanov, V.I.; Balan, C.; Bannon, A.W.; Bo, Y.; Dominguez, C.; Fotsch, C.; Gore, V.K.; Klionsky, L.; Ma, V.V.; Qian, Y.X.; et al. Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles. J. Med. Chem. 2006, 49, 3719-3742.
    • (2006) J. Med. Chem. , vol.49 , pp. 3719-3742
    • Ognyanov, V.I.1    Balan, C.2    Bannon, A.W.3    Bo, Y.4    Dominguez, C.5    Fotsch, C.6    Gore, V.K.7    Klionsky, L.8    Ma, V.V.9    Qian, Y.X.10
  • 180
    • 0034693266 scopus 로고    scopus 로고
    • Identification of an aspartic residue in the P-loop of the vanilloid receptor that modulates pore properties
    • Garcia-Martinez, C.; Morenilla-Palao, C.; Planells-Cases, R.; Merino, J.M.; Ferrer-Montiel, A. Identification of an aspartic residue in the P-loop of the vanilloid receptor that modulates pore properties. J. Biol. Chem. 2000, 275, 32552-32558.
    • (2000) J. Biol. Chem. , vol.275 , pp. 32552-32558
    • Garcia-Martinez, C.1    Morenilla-Palao, C.2    Planells-Cases, R.3    Merino, J.M.4    Ferrer-Montiel, A.5
  • 183
    • 28244475780 scopus 로고    scopus 로고
    • An inhibitor of TRPV1 channels isolated from funnel Web spider venom
    • Kitaguchi, T.; Swartz, K.J. An inhibitor of TRPV1 channels isolated from funnel Web spider venom. Biochemistry 2005, 44, 15544-15549.
    • (2005) Biochemistry , vol.44 , pp. 15544-15549
    • Kitaguchi, T.1    Swartz, K.J.2
  • 186
    • 23044496253 scopus 로고    scopus 로고
    • A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats
    • Honore, P.; Wismer, C.T.; Mikusa, J.; Zhu, C.Z.; Zhong, C.; Gauvin, D.M.; Gomtsyan, A.; el Kouhen, R.; Lee, C.H.; Marsh, K.; et al. A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats. J. Pharmacol. Exp. Ther. 2005, 314, 410-421.
    • (2005) J. Pharmacol. Exp. Ther. , vol.314 , pp. 410-421
    • Honore, P.1    Wismer, C.T.2    Mikusa, J.3    Zhu, C.Z.4    Zhong, C.5    Gauvin, D.M.6    Gomtsyan, A.7    El Kouhen, R.8    Lee, C.H.9    Marsh, K.10
  • 187
    • 0038128285 scopus 로고    scopus 로고
    • N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine-1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropathic pain
    • Pomonis, J.D.; Harrison, J.E.; Mark, L.; Bristol, D.R.; Valenzano, K.J.; Walker, K. N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine-1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropathic pain. J. Pharmacol. Exp. Ther. 2003, 306, 387-393.
    • (2003) J. Pharmacol. Exp. Ther. , vol.306 , pp. 387-393
    • Pomonis, J.D.1    Harrison, J.E.2    Mark, L.3    Bristol, D.R.4    Valenzano, K.J.5    Walker, K.6
  • 189
    • 0021737076 scopus 로고
    • Capsaicin and central control of thermoregulation
    • Hori, T. Capsaicin and central control of thermoregulation. Pharmacol. Ther. 1984, 26, 389-416.
    • (1984) Pharmacol. Ther. , vol.26 , pp. 389-416
    • Hori, T.1
  • 194
    • 84856269228 scopus 로고    scopus 로고
    • The thermo-TRP ion channel family: Properties and therapeutic implications
    • Vay, L.; Gu, C.; McNaughton, P.A. The thermo-TRP ion channel family: Properties and therapeutic implications. Br. J. Pharmacol. 2012, 165, 787-801.
    • (2012) Br. J. Pharmacol. , vol.165 , pp. 787-801
    • Vay, L.1    Gu, C.2    McNaughton, P.A.3


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