Agonist- and Ca2+-dependent desensitization of TRPV1 channel targets the receptor to lysosomes for degradation

Journal of Biological Chemistry

Volumn 287, Issue 23, 2012, Pages 19462-19471

  Sanz Salvador, Lucía ^a   Andrés Borderia, Amparo ^a   Ferrer Montiel, Antonio ^b   Planells Cases, Rosa ^a,b  

^a CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^b MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

NEURONS;

CELLULAR MECHANISMS; CHANNEL ACTIVATION; CHANNEL RECEPTORS; ENDOCYTIC ROUTE; EXPRESSION LEVELS; LYSOSOMAL DEGRADATION; MOLECULAR MECHANISM; RECEPTOR ENDOCYTOSIS;

MOLECULAR BIOLOGY;

CALCIUM ION; CLATHRIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; DYNAMIN; RECOMBINANT PROTEIN; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR AGONIST; ANTIPRURITIC AGENT; CALCIUM; CAPSAICIN; NERVE PROTEIN; TRPV1 PROTEIN, HUMAN; VANILLOID RECEPTOR;

ARTICLE; CALCIUM TRANSPORT; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; ENDOCYTOSIS; INTERNALIZATION; LYSOSOME; NOCICEPTIVE RECEPTOR; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RECEPTOR DOWN REGULATION; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; GENETICS; HUMAN; METABOLISM; NERVE CELL; PHOSPHORYLATION; PHYSIOLOGY; SECOND MESSENGER;

ANTIPRURITICS; CALCIUM; CAPSAICIN; CLATHRIN; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DYNAMINS; ENDOCYTOSIS; HEK293 CELLS; HUMANS; LYSOSOMES; NERVE TISSUE PROTEINS; NEURONS; NOCICEPTORS; PHOSPHORYLATION; PROTEOLYSIS; SECOND MESSENGER SYSTEMS; TRPV CATION CHANNELS;

EID: 84861732941     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.289751     Document Type: Article

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