Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six

Neuron

Volumn 82, Issue 5, 2014, Pages 1017-1031

  Jabba, Sairam ^a   Goyal, Raman ^a   Sosa Pagán, Jason O ^a   Moldenhauer, Hans ^b   Wu, Jason ^a   Kalmeta, Breanna ^a   Bandell, Michael ^c,d   Latorre, Ramon ^b   Patapoutian, Ardem ^c,d   Grandl, Jörg ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b Centro Interdisciplinario de Neurociencias de Valparaíso   (Chile)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYL ISOTHIOCYANATE; ANKYRIN; CAFFEINE; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1;

ACTION POTENTIAL; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CHANNEL GATING; CHO CELL LINE; COLD SENSITIVITY; CONTROLLED STUDY; DROSOPHILA; ELECTRIC CURRENT; ELECTRIC POTENTIAL; HEAT SENSITIVITY; ION CONDUCTANCE; MOUSE; MUTANT; NONHUMAN; PHYSICAL PARAMETERS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; STIMULUS RESPONSE; TEMPERATURE DEPENDENCE; TEMPERATURE SENSITIVITY; THERMAL CONDUCTIVITY; VOLTAGE SENSITIVITY; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; ANKYRIN REPEAT; CHO CELLS; CRICETULUS; DROSOPHILA; MICE; MOLECULAR SEQUENCE DATA; POINT MUTATION; TEMPERATURE; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84901827531     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2014.04.016     Document Type: Article

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