Transient receptor potential ankyrin 1 receptor activation in vitro and in vivo by pro-tussive agents: GRC 17536 as a promising anti-tussive therapeutic

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Mukhopadhyay, Indranil ^a   Kulkarni, Abhay ^a   Aranake, Sarika ^a   Karnik, Pallavi ^a   Shetty, Mahesh ^a   Thorat, Sandeep ^a   Ghosh, Indraneel ^a   Wale, Dinesh ^a   Bhosale, Vikram ^a   Khairatkar Joshi, Neelima ^a  

^a Glenmark Pharmaceuticals Limited   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITUSSIVE AGENT; CALCIUM ION; CITRIC ACID; DEXTROMETHORPHAN; GRC 17536; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; UNCLASSIFIED DRUG; CALCIUM; CALCIUM CHANNEL; LIGAND; NERVE PROTEIN; TOLL LIKE RECEPTOR; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRPA1 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; CHRONIC COUGH; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; FEMALE; HARTLEY GUINEA PIG; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; ANIMAL; CELL LINE; CHEMICALLY INDUCED; COUGH; DRUG EFFECTS; GUINEA PIG; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; ANTITUSSIVE AGENTS; BIOLOGICAL TRANSPORT; CALCIUM; CALCIUM CHANNELS; CELL LINE; CITRIC ACID; COUGH; GUINEA PIGS; HUMANS; LIGANDS; MALE; NERVE TISSUE PROTEINS; TOLL-LIKE RECEPTORS; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84901270872     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097005     Document Type: Article

References (47)

1. Chung KF, Pavord ID (2008) Prevalence, pathogenesis, and causes of chronic cough. Lancet 371: 1364-1374.
2. Chung KF (2003) Current and future prospects for drugs to suppress cough. IDrugs 6: 781-786.
3. Belvisi MG, Geppetti P (2004) Current and future drugs for the treatment of chronic cough. Thorax 59: 438-440.
4. Dicpinigaitis PV (2011) Cough: an unmet clinical need. Br J Pharmacol 163: 116-124.
5. Mazzone SB (2005) An overview of the sensory receptors regulating cough. Cough 1: 2.
6. Birrell MA, Belvisi MG, Grace M, Sadofsky L, Faruqi S, et al. (2009) TRPA1 agonists evoke coughing in guinea pig and human volunteers. Am J Respir Crit Care Med 180: 1042-1047.
7. Buckley J, Birrell MA, Maher SA, Nials AT, Clarke DL, et al. (2011) EP4 receptor as a new target for bronchodilator therapy. Thorax 66: 1029-1035.
8. Canning BJ (2009) Central regulation of the cough reflex: therapeutic implications. Pulm Pharmacol Ther 22: 75-81.
9. Nassenstein C, Kwong K, Taylor-Clark T, Kollarik M, Macglashan DM, et al. (2008) Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. J Physiol 586: 1595-1604.
10. Facchinetti F, Amadei F, Geppetti P, Tarantini F, Di Serio C, et al. (2007) Alpha, beta-unsaturated aldehydes in cigarette smoke release inflammatory mediators from human macrophages. Am J Respir Cell Mol Biol 37: 617-623.
11. Bessac BF, Sivula M, von Hehn CA, Escalera J, Cohn L, et al. (2008) TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin Invest 118: 1899-1910.
12. Facchinetti F, Patacchini R (2010) The rising role of TRPA1 in asthma. Open Drug Discov J 2: 71-80.
13. Mukhopadhyay I, Gomes P, Aranake S, Shetty M, Karnik P, et al. (2011) Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells. J Recept Signal Transduct 31: 350-358.
14. McMahon SB, Wood JN (2006) Increasingly irritable and close to tears: TRPA1 in inflammatory pain. Cell 124: 1123-1125.
15. Andrè E, Campi B, Materazzi S, Trevisani M, Amadesi S, et al. (2008) Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest 118: 2574-2582.
16. Shapiro D, Deering-Rice CE, Romero EG, Hughen RW, Light AR, et al. (2013) Activation of transient receptor potential ankyrin-1 (TRPA1) in lung cells by wood smoke particulate material. Chem Res Toxicol 26: 750-758.
17. Canning BJ (2010) Afferent nerves regulating the cough reflex: Mechanisms and Mediators of Cough in Disease. Otolaryngol Clin North Am 43: 15-25.
18. Silva-Carvalho L, Paton JF, Rocha I, Goldsmith GE, Spyer KM (1998) Convergence properties of solitary tract neurons responsive to cardiac receptor stimulation in the anesthetized cat. J Neurophysiol 79:2374-2382.
19. Mazzone SB, Mori N, Canning BJ (2005) Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs. J Physiol 569: 559-573.
20. Bezemer GFG, Sagar S, van Bergenhenegouwen J, Georgiou NA, Garssen J, et al. (2012) Dual Role of Toll-Like Receptors in Asthma and Chronic Obstructive Pulmonary Disease. Pharmacol Rev 64: 337-358.
21. Zhang L, Liu J, Bai J, Wang X, Li Y, et al. (2013) Comparative expression of Toll-like receptors and inflammatory cytokines in pigs infected with different virulent porcine reproductive and respiratory syndrome virus isolates. J Virol 10:135.
22. Qi J, Buzas K, Fan H, Cohen JI, Wang K, et al. (2011) Painful pathways induced by TLR stimulation of dorsal root ganglion neurons. J Immunol 186: 6417-6426.
23. Canning BJ, Farmer DG, Mori N (2006) Mechanistic studies of acid-evoked coughing in anesthetized guinea pigs. Am J Physiol Regul Integr Comp Physiol 291: R454-R463.
24. Wright CE, Jackson J, Thompson RL, Morice AH (2010) Validation of the ERS standard citric acid cough challenge in healthy adult volunteers. Cough 6: 8.
25. Wang YY, Chang RB, Allgood SD, Silver WL, Liman ER (2011) A TRPA1-dependent mechanism for the pungent sensation of weak acids. J Gen Physiol 137: 493-505.
26. Belvisi MG, Patel HJ, Freund-Michel V, Hele DJ, Crispino N, et al. (2008) Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guineapig and human sensory nerve function in the airways. Br J Pharmacol 155: 547-557.
27. Xia R, Dekermendjian K, Lullau E, Dekker N (2011) TRPV1: A therapy target that attracts the pharmaceutical interests. In: Islam S Md, editor. Advances in experimental medicine and biology; Transient receptor potential channels. Vol. 704London: Springer; pp. 637-666.
28. McCartney SA, Colonna M (2009) Viral sensors: diversity in pathogen recognition. Immunol Rev 227: 87-94.
29. Cherfils-Vicini J, Platonova S, Gillard M, Laurans L, Validire P, et al. (2010) Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance. J Clin Invest 120:1285-1297.
30. Bautista DM, Pellegrino M, Tsunozaki M (2013) TRPA1: A gatekeeper for inflammation. Annu Rev Physiol 75: 181-200.
31. Nassini R, Pedretti P, Moretto N, Fusi C, Carnini C, et al. (2012) Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation. PLoS One 7: e42454.
32. Andrè E, Gatti R, Trevisani M, Preti D, Baraldi PG, et al. (2009) Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents. Br J Pharmacol 158: 1621-1628.
33. Belvisi MG, Dubuis E, Birrell MA (2011) Transient receptor potential A1 channels: insights into cough and airway inflammatory disease. Chest 140:1040-1047.
34. Lavinka PC, Dong X (2013) Molecular signaling and targets from itch: lessons for cough. Cough 9: 8.
35. Taylor-Clark TE, Kiros F, Carr MJ, McAlexander MA (2009) Transient receptor potential ankyrin 1 mediates toluene diisocyanate-evoked respiratory irritation. Am J Respir Cell Mol Biol 40: 756-762.
36. Gu Q, Lin RL (2010) Heavy metals zinc, cadmium and copper stimulate pulmonary sensory neurons via direct activation of TRPA1. J Appl Physiol 108: 891-897.
37. Wang YY, Chang RB, Liman ER (2010) TRPA1 is a component of the nociceptive response to CO 2. J Neurosci 30: 12958-12963.
38. Akopian AN, Ruparel NB, Jeske NA, Hargreaves KM (2007) Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization. J Physiol 583: 175-193.
39. Raisinghani M, Zhong L, Jeffry JA, Bishnoi M, Pabbidi RM, et al. (2011) Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception. Am J Physiol Cell Physiol 301: C587-C600.
40. Reilly CA, Taylor JL, Lanza DL, Carr BA, Crouch DJ, et al. (2003) Capsaicinoids cause inflammation and epithelial cell death through activation of vanilloid receptors. Toxicol Sci 73: 170-181.
41. Morice AH (2011) Potential Role of TRP Channels in Cough Hypersensitivity? Curr Respir Med Rev 7: 10-13.
42. Schroeder K, Fahey T (2002) Systematic review of randomised controlled trials of over the counter cough medicines for acute cough in adults. BMJ 324: 329-331.
43. Hasday JD, Bascom R, Costa JJ, Fitzgerald T, Dubin W (1999) Bacterial endotoxin is an active component of cigarette smoke. Chest 115: 829-835.
44. Møller-Larsen S, Nyegaard M, Haagerup A, Vestbo J, Kruse TA, et al. (2008) Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders. Thorax 63: 1064-1069.
45. Cherfils-Vicini J, Platonova S, Gillard M, Laurans L, Validire P, et al. (2010) Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance. J Clin Invest 120: 1285-1297.
46. Becker J, Hackl M, Rupp O, Jakobi T, Schneider J, et al. (2011) Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. J Biotechnol 156: 227-235.
47. Xu X, Nagarajan H, Lewis NE, Pan S, Cai Z, et al. (2011) The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line. Nat Biotechnol 29: 735-741.