Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner

Pflugers Archiv European Journal of Physiology

Volumn 463, Issue 4, 2012, Pages 549-559

  Komatsu, Tomoko ^a,b   Uchida, Kunitoshi ^a,c   Fujita, Fumitaka ^d   Zhou, Yiming ^a,c   Tominaga, Makoto ^a,c  

^a NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^b JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^c GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^d C   (Japan)

Author keywords

Alcohol; Calcium imaging; Pain; Patch clamp; Sensory neurons; Transient receptor potential

Indexed keywords

ALCOHOL; CALCIUM ION; ION CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1;

ACTION POTENTIAL; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CELL LEVEL; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENZYME ACTIVATION; ENZYME ANALYSIS; HUMAN; HUMAN CELL; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION;

1-BUTANOL; 1-OCTANOL; ALCOHOLS; ANIMALS; CALCIUM; CALCIUM CHANNELS; CELL LINE; CELLS, CULTURED; HEK293 CELLS; HEXANOLS; HUMANS; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR STRUCTURE; MUTATION; NERVE TISSUE PROTEINS; NEURONS; PATCH-CLAMP TECHNIQUES; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84862608453     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-011-1069-4     Document Type: Article

References (35)

1. 2+. Proc Natl Acad Sci USA 106:8374-8379
2. Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, Earley TJ, Patapoutian A (2004) Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41:849-857 (Pubitemid 38429729)
3. Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D (2006) TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124:1269-1282
4. Caspani O, Heppenstall PA (2009) TRPA1 and cold transduction: an unresolved issue? J Gen Physiol 133:245-249
5. Cometto-Muniz JE, Cain WS (1995) Relative sensitivity of the ocular trigeminal, nasal trigeminal and olfactory systems to airborne chemicals. Chem Senses 20:191-198
6. Doerner JF, Gisselmann G, Hatt H, Wetzel CH (2007) Transient receptor potential channel A1 is directly gated by calcium ions. J Biol Chem 282:13180-13189 (Pubitemid 47100541)
7. Dopico AM, Lovinger DM (2009) Acute alcohol action and desensitization of ligand-gated ion channels. Pharmacol Rev 61:98-114
8. Eilers H, Cattaruzza F, Nassini R, Materazzi S, Andre E, Chu C, Cottrell GS, Schumacher M, Geppetti P, Bunnett NW (2010) Pungent general anesthetics activate transient receptor potential- A1 to produce hyperalgesia and neurogenic bronchoconstriction. Anesthesiology 112:1452-1463
9. Forman SA (1997) Homologous mutations on different subunits cause unequal but additive effects on n-alcohol block in the nicotinic receptor pore. Biophys J 72:2170-2179
10. Fujii M, Okano Y, Masaki H (1989) Skin sensory stimulation. J Soc Cosmet Chem Jpn 22:229-235
11. Fujita F, Moriyama T, Higashi T, Shima A, Tominaga M (2007) Methyl p-hydroxybenzoate causes pain sensation through activation of TRPA1 channels. Br J Pharmacol 151:153-160
12. Fujita F, Uchida K, Moriyama T, Shima A, Shibasaki K, Inada H, Sokabe T, Tominaga M (2008) Intracellular alkalization causes pain sensation through activation of TRPA1 in mice. J Clin Invest 118:4049-4057
13. Hammes-Schiffer S, Benkovic SJ (2006) Relating protein motion to catalysis. Annu Rev Biochem 75:519-541 (Pubitemid 44118042)
14. Hinman A, Chuang HH, Bautista DM, Julius D (2006) TRP channel activation by reversible covalent modification. Proc Natl Acad Sci USA 103:19564-19568 (Pubitemid 46026070)
15. Hu H, Bandell M, Petrus MJ, Zhu MX, Patapoutian A (2009) Zinc activates damage-sensing TRPA1 ion channels. Nat Chem Biol 5:183-190
16. Hu H, Tian J, Zhu Y, Wang C, Xiao R, Herz JM, Wood JD, Zhu MX (2010) Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. Pflugers Arch 459:579-592
17. Jacobs GA (1987) OECD Eye Irritation Test on 1-C8OH. J Am Coll Toxicol 11:726
18. Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Hogestatt ED, Meng ID, Julius D (2004) Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427:260-265 (Pubitemid 38112043)
19. Karashima Y, Damann N, Prenen J, Talavera K, Segal A, Voets T, Nilius B (2007) Bimodal action of menthol on the transient receptor potential channel TRPA1. J Neurosci 27:9874-9884 (Pubitemid 47403994)
20. Karashima Y, Talavera K, Everaerts W, Janssens A, Kwan KY, Vennekens R, Nilius B, Voets T (2009) TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci USA 106:1273-1278
21. Kwan KY, Allchorne AJ, Vollrath MA, Christensen AP, Zhang DS, Woolf CJ, Corey DP (2006) TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron 50:277-289
22. Macpherson LJ, Dubin AE, Evans MJ, Marr F, Schultz PG, Cravatt BF, Patapoutian A (2007) Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445:541-545 (Pubitemid 46197634)
23. Matta JA, Cornett PM, Miyares RL, Abe K, Sahibzada N, Ahern GP (2008) General anesthetics activate a nociceptive ion channel to enhance pain and inflammation. Proc Natl Acad Sci USA 105:8784-8789 (Pubitemid 351987757)
24. Mihic SJ, Ye Q,Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, Harris RA, Harrison NL (1997) Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. Nature 389:385-389 (Pubitemid 27415220)
25. Morita A, Iwasaki Y, Kobata K, Iida T, Higashi T, Oda K, Suzuki A, Narukawa M, Sasakuma S, Yokogoshi H, Yazawa S, Tominaga M, Watanabe T (2006) Lipophilicity of capsaicinoids and capsinoids influences the multiple activation process of rat TRPV1. Life Sci 79:2303-2310 (Pubitemid 44666065)
26. - current by a series of n-alcohols disappears at a cutoff point of a longer-chain n-alcohol in rat dorsal root ganglion neurons. Neurosci Lett 205:127-130
27. Neeper MP, Liu Y, Hutchinson TL, Wang Y, Flores CM, Qin N (2007) Activation properties of heterologously expressed mammalian TRPV2: evidence for species dependence. J Biol Chem 282:15894-15902 (Pubitemid 47093309)
28. Peyrot des Gachons C, Uchida K, Bryant B, Shima A, Sperry JB, Dankulich-Nagrudny L, Tominaga M, Smith AB 3rd, Beauchamp GK, Breslin PA (2011) Unusual pungency from extra-virgin olive oil is attributable to restricted spatial expression of the receptor of oleocanthal. J Neurosci 31:999-1009
29. + and substituted benzyl alcohols. Biochemistry 33:5230-5237
30. Sato A, Obata K, Ikeda Y, Ohkoshi K, Okumura H, Ozawa N, Ogawa T, Katsumura Y, Kawai J, Tatsumi H, Honoki S, Hiramatsu I, Hiroyama H, Okada T, Kozuka T (1996) Evaluation of human skin irritation by carboxylic acids, alcohols, esters and aldehydes, with nitrocellulose-replica method and closed patch testing. Contact Dermatitis 34:12-16 (Pubitemid 26019821)
31. Shearer GL, Kim K, Lee KM, Wang CK, Plapp BV (1993) Alternative pathways and reactions of benzyl alcohol and benzaldehyde with horse liver alcohol dehydrogenase. Biochemistry 32:11186-11194 (Pubitemid 23332027)
32. Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, Earley TJ, Hergarden AC, Andersson DA, Hwang SW, McIntyre P, Jegla T, Bevan S, Patapoutian A (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112:819-829 (Pubitemid 36378884)
33. Trevisani M, Smart D, Gunthorpe MJ, Tognetto M, Barbieri M, Campi B, Amadesi S, Gray J, Jerman JC, Brough SJ, Owen D, Smith GD, Randall AD, Harrison S, Bianchi A, Davis JB, Geppetti P (2002) Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1. Nat Neurosci 5:546-551 (Pubitemid 34568996)
34. Ursu D, Knopp K, Beattie RE, Liu B, Sher E (2010) Pungency of TRPV1 agonists is directly correlated with kinetics of receptor activation and lipophilicity. Eur J Pharmacol 641:114-122
35. 2+. Nat Neurosci 10:277-279