TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel

FASEB Journal

Volumn 28, Issue 11, 2014, Pages 4677-4685

  Du, Juan ^a,b   Ma, Xin ^a   Shen, Bing ^a,b   Huang, Yu ^a   Birnbaumer, Lutz ^c   Yao, Xiaoqiang ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b ANHUI MEDICAL UNIVERSITY   (China)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Ca2+; Endothelial cells; Mesenteric artery; Shear stress

Indexed keywords

CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; POLYCYSTIN 2; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; VANILLOID RECEPTOR 4; POLYCYSTIN; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY C, MEMBER 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPV4 PROTEIN, HUMAN; TRPV4 PROTEIN, RAT; VANILLOID RECEPTOR;

ANIMAL CELL; ARTICLE; CELL MOTION; CONTROLLED STUDY; ENDOTHELIUM CELL; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MALE; MEMBRANE STEADY POTENTIAL; MESENTERIC ARTERY; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; REGULATORY MECHANISM; VASODILATATION; WHOLE CELL PATCH CLAMP; ANIMAL; CELL LINE; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; CELL LINE; ENDOTHELIAL CELLS; HUMANS; MESENTERIC ARTERIES; RATS, SPRAGUE-DAWLEY; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPC CATION CHANNELS; TRPP CATION CHANNELS; TRPV CATION CHANNELS;

EID: 84912111747     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-251652     Document Type: Article

References (25)

1. 2+ channels TRPV5 and TRPV6. EMBO J. 22, 776-785
2. Cheng, W., Sun, C., and Zheng, J. (2010) Heteromerization of TRP channel subunits: extending functional diversity. Protein Cell 1, 802-810
3. Hofmann, T., Schaefer, M., Schultz, G., and Gudermann, T. (2002) Subunit composition of mammalian transient receptor potential channels in living cells. Proc. Natl. Acad. Sci. U. S. A. 99, 7461-7466
4. Tsiokas, L., Arnould, T., Zhu, C., Kim, E., Walz, G., and Sukhatme, V. P. (1999) Specific association of the gene product of PKD2 with the TRPC1 channel. Proc. Natl. Acad. Sci. U. S. A. 96, 3934-3939
5. Bai, C. X., Giamarchi, A., Rodat-Despoix, L., Padilla, F., Downs, T., Tsiokas, L., and Delmas, P. (2008) Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits. EMBO Rep. 9, 472-479
6. Köttgen, M., Buchholz, B., Garcia-Gonzalez, M. A., Kotsis, F., Fu, X., Doerken, M., Boehlke, C., Steffl, D., Tauber, R., Wegierski, T., Nitschke, R., Suzuki, M., Kramer-Zucker, A., Germino, G. G., Watnick, T., Prenen, J., Nilius, B., Kuehn, E. W., and Walz, G. (2008) TRPP2 and TRPV4 form a polymodal sensory channel complex. J. Cell Biol. 182, 437-447
7. 2+ influx. Arterioscler. Thromb. Vasc. Biol. 30, 851-858
8. Ma. X., Nilius, B., Wong, J. W., Huang, Y., and Yao, X. (2011) Electrophysiological properties of heteromeric TRPV4-C1 channels. Biochim. Biophyis. Acta 1808, 2789-2797
9. Bevan, J. A., Kaley, G., and Rubanyi, G. M. (1995) Flow-Dependent Regulation of Vascular Function. Oxford University Press, New York
10. Hartmannsgruber, V., Heyken, W. T., Kacik, M., Kaistha, A., Grgic, I., Harteneck, C., Liedtke, W., Hoyer, J., and Köhler, R. (2007) Arterial response to shear stress critically depends on endothelial TRPV4 expression. PLoS One 2, e827
11. AbouAlaiwi, W. A., Takahashi, M., Mell, B. R., Jones, T. J., Ratnam, S., Kolb, R. J., and Nauli, S. M. (2009) Ciliary polycystin- 2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades. Circ. Res. 104, 860-869
12. Harada, J., Kokura, K., Kanei-Ishii, C., Nomura, T., Khan, M. M., Kim, Y., and Ishii, S. (2003) Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation. J. Biol. Chem. 278, 38998-39005
13. Zheng, J., Trudeau, M. C., and Zagotta, W. N. (2002) Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit. Neuron 36, 891-896
14. Barakat, A. I., Leaver, E. V., Pappone, P. A., and Davies, P. F. (1999) A flow-activated chloride-selective membrane current in vascular endothelial cells. Circ. Res. 85, 820-828
15. Voets, T., Prenen, J., Vriens, J., Watanabe, H., Janssens, A., Wissenbach, U., Bodding, M., Droogmans, G., and Nilius, B. (2002) Molecular determinants of permeation through the cation channel TRPV4. J. Biol. Chem. 277, 33704-33710
16. Maroto, R., Raso, A., Wood, T. G., Kurosky, A., Martinac, B., and Hamill, O. P. (2005) TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nat. Cell Biol. 7, 179-185
17. Yang, X. R., Lin, M. J., McIntosh, L. S., and Sham, J. S. (2006) Functional expression of transient receptor potential melastatin- and vanilloid-related channels in pulmonary arterial and aortic smooth muscle. Am. J. Physiol. Lung Cell. Mol. Physiol. 290, L1267-L1276
18. 2+ channels: role of acidic amino acid residues in the S5-S6 region. J. Biol. Chem. 278, 11337-11343
19. Ma, R., Li, W. P., Rundle, D., Kong, J., Akbarali, H. I., and Tsiokas, L. (2005) PKD2 functions as an epidermal growth factor-activated plasma membrane channel. Mol. Cell. Biol. 25, 8285-8298
20. Olesen, S., Clapham, D. E., and Davies, P. F. (1988) Haemodynamic shear stress activates a K+ current in vascular endothelial cells. Nature 331, 168-170
21. 2+ entry in endothelial cells. FASEB J. 14, 932-938
22. 2+, a negative feedback control. Trends Pharmacol. Sci. 24, 263-266
23. 2+ influx in rat endothelial cells. Circ. Res. 92, 286-292
24. 2+ influx in bovine aortic endothelial cells. Circ. Res. 88, 925-932
25. Bähre, H., Danker, K. Y., Stasch, J. P., Kaever, V., and Seifert, R. (2014) Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells. Biochem. Biophys. Res. Commun. 443, 1195-1199