-
1
-
-
84655164303
-
Neuroinflammation: Modulation by flavonoids and mechanisms of action
-
Spencer JPE, Vafeiadou K, Williams RJ, Vauzour D. Neuroinflammation: modulation by flavonoids and mechanisms of action. Mol Aspects Med. 2012;33(1):83-97.
-
(2012)
Mol Aspects Med
, vol.33
, Issue.1
, pp. 83-97
-
-
Spencer, J.P.E.1
Vafeiadou, K.2
Williams, R.J.3
Vauzour, D.4
-
2
-
-
77954977618
-
Neuroinflammation in Alzheimer’s disease: Mechanisms, pathologic consequences, and potential for therapeutic manipulation
-
Hensley K. Neuroinflammation in Alzheimer’s disease: mechanisms, pathologic consequences, and potential for therapeutic manipulation. J Alzheimers Dis. 2010;21(1):1-14.
-
(2010)
J Alzheimers Dis
, vol.21
, Issue.1
, pp. 1-14
-
-
Hensley, K.1
-
3
-
-
75149118999
-
Neuroinflammation in Alzheimer’s disease and mild cognitive impairment: A field in its infancy
-
McGeer EG, McGeer PL. Neuroinflammation in Alzheimer’s disease and mild cognitive impairment: a field in its infancy. J Alzheimer Dis. 2010;19(1):355-361.
-
(2010)
J Alzheimer Dis
, vol.19
, Issue.1
, pp. 355-361
-
-
McGeer, E.G.1
McGeer, P.L.2
-
4
-
-
0041784698
-
Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria
-
Brown GC, Bal-Price A. Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria. Mol Neurobiol. 2003;27(3):325-355.
-
(2003)
Mol Neurobiol
, vol.27
, Issue.3
, pp. 325-355
-
-
Brown, G.C.1
Bal-Price, A.2
-
5
-
-
84883139252
-
Regulation of immune cell infiltration into the CNS by regional neural Inputs explained by the gate theory
-
Arima Y, Kamimura D, Sabharwal L, et al. Regulation of immune cell infiltration into the CNS by regional neural Inputs explained by the gate theory. Mediators Inflamm. 2013;2013:898165.
-
(2013)
Mediators Inflamm
, vol.2013
-
-
Arima, Y.1
Kamimura, D.2
Sabharwal, L.3
-
6
-
-
29244463365
-
Astrocyte-endothelial interactions at the blood-brain barrier
-
Abbott NJ, Rönnbäck L, Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci. 2006;7(1):41-53.
-
(2006)
Nat Rev Neurosci
, vol.7
, Issue.1
, pp. 41-53
-
-
Abbott, N.J.1
Rönnbäck, L.2
Hansson, E.3
-
7
-
-
84882721669
-
Blood-brain barrier and blood-nerve barrier in neuroinflammatory diseases
-
Maeda T, Kanda T. Blood-brain barrier and blood-nerve barrier in neuroinflammatory diseases. Nippon Rinsho. 2013;71(5):789-794.
-
(2013)
Nippon Rinsho
, vol.71
, Issue.5
, pp. 789-794
-
-
Maeda, T.1
Kanda, T.2
-
8
-
-
84874038104
-
Advances in PET imaging of P-glycoprotein function at the blood-brain barrier
-
Syvanen S, Eriksson J. Advances in PET imaging of P-glycoprotein function at the blood-brain barrier. ACS Chem Neurosci. 2013;4(2):225-237.
-
(2013)
ACS Chem Neurosci
, vol.4
, Issue.2
, pp. 225-237
-
-
Syvanen, S.1
Eriksson, J.2
-
9
-
-
84890490409
-
Functional and molecular characterization of the effect of amyloid-beta(42) on an in vitro epithelial barrier model
-
Gheorghiu M, Enciu A-M, Popescu BO, Gheorghiu E. Functional and molecular characterization of the effect of amyloid-beta(42) on an in vitro epithelial barrier model. J Alzheimers Dis. 2014;38(4):787-798.
-
(2014)
J Alzheimers Dis
, vol.38
, Issue.4
, pp. 787-798
-
-
Gheorghiu, M.1
Enciu, A.-M.2
Popescu, B.O.3
Gheorghiu, E.4
-
10
-
-
84878887419
-
Amyloid-beta interacts with blood-brain barrier function in dementia: A systematic review
-
Burgmans S, van de Haar HJ, Verhey FRJ, Backes WH. Amyloid-beta interacts with blood-brain barrier function in dementia: a systematic review. J Alzheimers Dis. 2013;35(4):859-873.
-
(2013)
J Alzheimers Dis
, vol.35
, Issue.4
, pp. 859-873
-
-
Burgmans, S.1
van de Haar, H.J.2
Verhey, F.R.J.3
Backes, W.H.4
-
11
-
-
84872552966
-
Inflammatory cytokines at the summits of pathological signal cascades in brain diseases
-
Steinman L. Inflammatory cytokines at the summits of pathological signal cascades in brain diseases. Sci Signal. 2013;6(258):e3.
-
(2013)
Sci Signal
, vol.6
, Issue.258
-
-
Steinman, L.1
-
12
-
-
84860218969
-
Neuroinflammation and blood-brain barrier changes in capillary amyloid angiopathy
-
Carrano A, Hoozemans JJM, van der Vies SM, van Horssen J, de Vries HE, Rozemuller AJM. Neuroinflammation and blood-brain barrier changes in capillary amyloid angiopathy. Neurodegene Dis. 2012;10(1-4):329-331.
-
(2012)
Neurodegene Dis
, vol.10
, Issue.1-4
, pp. 329-331
-
-
Carrano, A.1
Hoozemans, J.J.M.2
van der Vies, S.M.3
van Horssen, J.4
de Vries, H.E.5
Rozemuller, A.J.M.6
-
13
-
-
0034105064
-
How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli
-
Rivest S, Lacroix S, Vallières L, Nadeau S, Zhang J, Laflamme N. How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli. Proc Soc Exp Biol Med. 2000;223(1):22-38.
-
(2000)
Proc Soc Exp Biol Med
, vol.223
, Issue.1
, pp. 22-38
-
-
Rivest, S.1
Lacroix, S.2
Vallières, L.3
Nadeau, S.4
Zhang, J.5
Laflamme, N.6
-
14
-
-
84877586983
-
Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model
-
Takeda S, Sato N, Ikimura K, Nishino H, Rakugi H, Morishita R. Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model. Neurobiol Aging. 2013;34(8):2064-2070.
-
(2013)
Neurobiol Aging
, vol.34
, Issue.8
, pp. 2064-2070
-
-
Takeda, S.1
Sato, N.2
Ikimura, K.3
Nishino, H.4
Rakugi, H.5
Morishita, R.6
-
15
-
-
84939214542
-
-
Inventor; (MISC-Individual), assignee, US patent US2013079682-A1, Mar 28
-
Mischelevich DJ, Inventor; MISCHELEVICH DJ, (MISC-Individual), assignee. Method for altering permeability of blood-brain barrier in patient for use in treatment of eg., Alzheimer disease, involves energizing transducer to deliver pulsed ultrasound energy to target in brain or spinal cord. US patent US2013079682-A1. 2013 Mar 28.
-
(2013)
Method for altering permeability of blood-brain barrier in patient for use in treatment of eg., Alzheimer disease, involves energizing transducer to deliver pulsed ultrasound energy to target in brain or spinal cord
-
-
Mischelevich, D.J.1
Mischelevich, D.J.2
-
16
-
-
80052837439
-
Reactive Glia not only associates with plaques but also parallels tangles in Alzheimer’s disease
-
Serrano-Pozo A, Mielke ML, Gómez-Isla T, et al. Reactive Glia not only associates with plaques but also parallels tangles in Alzheimer’s disease. Am J Pathol. 2011;179(3):1373-1384.
-
(2011)
Am J Pathol
, vol.179
, Issue.3
, pp. 1373-1384
-
-
Serrano-Pozo, A.1
Mielke, M.L.2
Gómez-Isla, T.3
-
17
-
-
33847613885
-
Inflammatory processes in Alzheimer’s disease
-
Heneka MT, O’Banion MK. Inflammatory processes in Alzheimer’s disease. J Neuroimmunol. 2007;184(1):69-91.
-
(2007)
J Neuroimmunol
, vol.184
, Issue.1
, pp. 69-91
-
-
Heneka, M.T.1
O’Banion, M.K.2
-
19
-
-
84875965538
-
Origin and differentiation of microglia
-
Ginhoux F, Lim S, Hoeffel G, Low D, Huber T. Origin and differentiation of microglia. Front Cell Neurosci. 2013;17:7.
-
(2013)
Front Cell Neurosci
, vol.17
, pp. 7
-
-
Ginhoux, F.1
Lim, S.2
Hoeffel, G.3
Low, D.4
Huber, T.5
-
20
-
-
77950363010
-
Mechanisms underlying inflammation in neurodegeneration
-
Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH. Mechanisms underlying inflammation in neurodegeneration. Cell. 2010;140(6):918-934.
-
(2010)
Cell
, vol.140
, Issue.6
, pp. 918-934
-
-
Glass, C.K.1
Saijo, K.2
Winner, B.3
Marchetto, M.C.4
Gage, F.H.5
-
21
-
-
84869161077
-
Regulation of microglia development and homeostasis
-
Greter M, Merad M. Regulation of microglia development and homeostasis. Glia. 2013;61(1):121-127.
-
(2013)
Glia
, vol.61
, Issue.1
, pp. 121-127
-
-
Greter, M.1
Merad, M.2
-
22
-
-
33845768784
-
Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
-
Block ML, Zecca L, Hong J-S. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci. 2007;8(1):57-69.
-
(2007)
Nat Rev Neurosci
, vol.8
, Issue.1
, pp. 57-69
-
-
Block, M.L.1
Zecca, L.2
Hong, J.-S.3
-
23
-
-
84857008054
-
Microglia in the developing brain: A potential target with lifetime effects
-
Harry GJ, Kraft AD. Microglia in the developing brain: a potential target with lifetime effects. Neurotoxicology. 2012;33(2):191-206.
-
(2012)
Neurotoxicology
, vol.33
, Issue.2
, pp. 191-206
-
-
Harry, G.J.1
Kraft, A.D.2
-
24
-
-
84892695369
-
Tau oligomers and fibrils induce activation of microglial cells
-
Morales I, Jimenez JM, Mancilla M, Maccioni RB. Tau oligomers and fibrils induce activation of microglial cells. J Alzheimers Dis. 2013;37(4):849-856.
-
(2013)
J Alzheimers Dis
, vol.37
, Issue.4
, pp. 849-856
-
-
Morales, I.1
Jimenez, J.M.2
Mancilla, M.3
McCioni, R.B.4
-
25
-
-
77949491472
-
Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer’s disease
-
Rodriguez JJ, Witton J, Olabarria M, Noristani HN, Verkhratsky A. Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer’s disease. Cell Death Dis. 2010;1:e1.
-
(2010)
Cell Death Dis
, vol.1
-
-
Rodriguez, J.J.1
Witton, J.2
Olabarria, M.3
Noristani, H.N.4
Verkhratsky, A.5
-
26
-
-
84878433339
-
Alzheimer’s disease risk gene CD33 inhibits microglial uptake of amyloid beta
-
Griciuc A, Serrano-Pozo A, Parrado AR, et al. Alzheimer’s disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron. 2013;78(4):631-643.
-
(2013)
Neuron
, vol.78
, Issue.4
, pp. 631-643
-
-
Griciuc, A.1
Serrano-Pozo, A.2
Parrado, A.R.3
-
27
-
-
80054088628
-
Determination of spatial and temporal distribution of microglia by 230 nm-high-resolution, high-throughput automated analysis reveals different amyloid plaque populations in an APP/PS1 mouse model of Alzheimer’s disease
-
Scheffler K, Stenzel J, Krohn M, et al. Determination of spatial and temporal distribution of microglia by 230 nm-high-resolution, high-throughput automated analysis reveals different amyloid plaque populations in an APP/PS1 mouse model of Alzheimer’s disease. Curr Alzheimer Res. 2011;8(7):781-788.
-
(2011)
Curr Alzheimer Res
, vol.8
, Issue.7
, pp. 781-788
-
-
Scheffler, K.1
Stenzel, J.2
Krohn, M.3
-
28
-
-
0013615899
-
RAGE and amyloid-β peptide neurotoxicity in Alzheimer’s disease
-
Du Yan S, Chen X, Fu J, et al. RAGE and amyloid-β peptide neurotoxicity in Alzheimer’s disease. Nature. 1996;382(6593):685-691.
-
(1996)
Nature
, vol.382
, Issue.6593
, pp. 685-691
-
-
Du Yan, S.1
Chen, X.2
Fu, J.3
-
29
-
-
0031957224
-
Microglia, scavenger receptors, and the pathogenesis of Alzheimer’s disease
-
El Khoury J, Hickman S, Thomas C, Loike J, Silverstein S. Microglia, scavenger receptors, and the pathogenesis of Alzheimer’s disease. Neurobiol Aging. 1998;19(1):S81-S84.
-
(1998)
Neurobiol Aging
, vol.19
, Issue.1
, pp. S81-S84
-
-
El Khoury, J.1
Hickman, S.2
Thomas, C.3
Loike, J.4
Silverstein, S.5
-
30
-
-
0346101885
-
Enhanced proteolysis of β-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
-
Leissring MA, Farris W, Chang AY, et al. Enhanced proteolysis of β-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron. 2003;40(6):1087-1093.
-
(2003)
Neuron
, vol.40
, Issue.6
, pp. 1087-1093
-
-
Leissring, M.A.1
Farris, W.2
Chang, A.Y.3
-
31
-
-
79954422020
-
Regulation of matrix metalloproteinase 2 by oligomeric amyloid β protein
-
Li W, Poteet E, Xie L, Liu R, Wen Y, Yang S-H. Regulation of matrix metalloproteinase 2 by oligomeric amyloid β protein. Brain Res. 2011;1387:141-148.
-
(2011)
Brain Res
, vol.1387
, pp. 141-148
-
-
Li, W.1
Poteet, E.2
Xie, L.3
Liu, R.4
Wen, Y.5
Yang, S.-H.6
-
32
-
-
0037215645
-
Role of microglia in inflammation-mediated neurodegenerative diseases: Mechanisms and strategies for therapeutic intervention
-
Liu B, Hong J-S. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J Pharmacol Exp Ther. 2003;304(1):1-7.
-
(2003)
J Pharmacol Exp Ther
, vol.304
, Issue.1
, pp. 1-7
-
-
Liu, B.1
Hong, J.-S.2
-
33
-
-
79954518984
-
The role of microglial cell subsets in Alzheimer’s disease
-
Naert G, Rivest S. The role of microglial cell subsets in Alzheimer’s disease. Curr Alzheimer Res. 2011;8(2):151-155.
-
(2011)
Curr Alzheimer Res
, vol.8
, Issue.2
, pp. 151-155
-
-
Naert, G.1
Rivest, S.2
-
34
-
-
51149120624
-
Microglial dysfunction and defective β-amyloid clearance pathways in aging Alzheimer’s disease mice
-
Hickman SE, Allison EK, El Khoury J. Microglial dysfunction and defective β-amyloid clearance pathways in aging Alzheimer’s disease mice. J Neurosci. 2008;28(33):8354-8360.
-
(2008)
J Neurosci
, vol.28
, Issue.33
, pp. 8354-8360
-
-
Hickman, S.E.1
Allison, E.K.2
El Khoury, J.3
-
35
-
-
79960744467
-
Microglia demonstrate age-dependent interaction with amyloid-beta fibrils
-
Floden AM, Combs CK. Microglia demonstrate age-dependent interaction with amyloid-beta fibrils. J Alzheimers Dis. 2011;25(2):279-293.
-
(2011)
J Alzheimers Dis
, vol.25
, Issue.2
, pp. 279-293
-
-
Floden, A.M.1
Combs, C.K.2
-
36
-
-
84876006819
-
Functional impairment of microglia coincides with beta-amyloid deposition in mice with Alzheimer-like pathology
-
Krabbe G, Halle A, Matyash V, et al. Functional impairment of microglia coincides with beta-amyloid deposition in mice with Alzheimer-like pathology. PLoS One. 2013;8(4):e60921.
-
(2013)
PLoS One
, vol.8
, Issue.4
-
-
Krabbe, G.1
Halle, A.2
Matyash, V.3
-
37
-
-
35548986304
-
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
-
Hanisch UK, Kettenmann H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci. 2007;10(11):1387-1394.
-
(2007)
Nat Neurosci
, vol.10
, Issue.11
, pp. 1387-1394
-
-
Hanisch, U.K.1
Kettenmann, H.2
-
38
-
-
84873087532
-
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
-
Heneka MT, Kummer MP, Stutz A, et al. NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice. Nature. 2012;493(7434):674-678.
-
(2012)
Nature
, vol.493
, Issue.7434
, pp. 674-678
-
-
Heneka, M.T.1
Kummer, M.P.2
Stutz, A.3
-
39
-
-
33748806586
-
Evolution of increased glia-neuron ratios in the human frontal cortex
-
Sherwood CC, Stimpson CD, Raghanti MA, et al. Evolution of increased glia-neuron ratios in the human frontal cortex. Proc Natl Acad Sci U S A. 2006;103(37):13606-13611.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.37
, pp. 13606-13611
-
-
Sherwood, C.C.1
Stimpson, C.D.2
Raghanti, M.A.3
-
40
-
-
33846571886
-
The origin and cell lineage of microglia-new concepts
-
Chan WY, Kohsaka S, Rezaie P. The origin and cell lineage of microglia-new concepts. Brain Res Rev. 2007;53(2):344-354.
-
(2007)
Brain Res Rev
, vol.53
, Issue.2
, pp. 344-354
-
-
Chan, W.Y.1
Kohsaka, S.2
Rezaie, P.3
-
41
-
-
84860530692
-
Astrocytes and disease: A neurodevelopmental perspective
-
Molofsky AV, Krencik R, Ullian EM, et al. Astrocytes and disease: a neurodevelopmental perspective. Genes Dev. 2012;26(9):891-907.
-
(2012)
Genes Dev
, vol.26
, Issue.9
, pp. 891-907
-
-
Molofsky, A.V.1
Krencik, R.2
Ullian, E.M.3
-
42
-
-
84867753337
-
Structural remodeling of astrocytes in the injured CNS
-
Sun D, Jakobs TC. Structural remodeling of astrocytes in the injured CNS. Neuroscientist. 2012;18(6):567-588.
-
(2012)
Neuroscientist
, vol.18
, Issue.6
, pp. 567-588
-
-
Sun, D.1
Jakobs, T.C.2
-
43
-
-
79959492122
-
Role of astrocytes in brain function and disease
-
Sidoryk-Wegrzynowicz M, Wegrzynowicz M, Lee E, Bowman AB, Aschner M. Role of astrocytes in brain function and disease. Toxicol Pathol. 2011;39(1):115-123.
-
(2011)
Toxicol Pathol
, vol.39
, Issue.1
, pp. 115-123
-
-
Sidoryk-Wegrzynowicz, M.1
Wegrzynowicz, M.2
Lee, E.3
Bowman, A.B.4
Aschner, M.5
-
44
-
-
84861743669
-
Oligomers of beta-amyloid protein (A beta 1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1beta, tumour necrosis factor-alpha, and a nuclear factor kappa-B mechanism in the rat brain
-
Carrero I, Gonzalo MR, Martin B, Sanz-Anquela JM, Arevalo-Serrano J, Gonzalo-Ruiz A. Oligomers of beta-amyloid protein (A beta 1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1beta, tumour necrosis factor-alpha, and a nuclear factor kappa-B mechanism in the rat brain. Exp Neurol. 2012;236(2):215-227.
-
(2012)
Exp Neurol
, vol.236
, Issue.2
, pp. 215-227
-
-
Carrero, I.1
Gonzalo, M.R.2
Martin, B.3
Sanz-Anquela, J.M.4
Arevalo-Serrano, J.5
Gonzalo-Ruiz, A.6
-
45
-
-
84868252916
-
Astrocytes: Conductors of the Alzheimer disease neuroinflammatory symphony
-
Medeiros R, LaFerla FM. Astrocytes: conductors of the Alzheimer disease neuroinflammatory symphony. Exp Neurol. 2013;239:133-138.
-
(2013)
Exp Neurol
, vol.239
, pp. 133-138
-
-
Medeiros, R.1
LaFerla, F.M.2
-
46
-
-
84939214547
-
Astrocyte senescence as a component of Alzheimer’s disease
-
Crowe E, Bhat R, Bitto A, et al. Astrocyte senescence as a component of Alzheimer’s disease. Exp Gerontol. 2013;48(7):695-696.
-
(2013)
Exp Gerontol
, vol.48
, Issue.7
, pp. 695-696
-
-
Crowe, E.1
Bhat, R.2
Bitto, A.3
-
47
-
-
0034523456
-
Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes
-
Blasko I, Veerhuis R, Stampfer-Kountchev M, Saurwein-Teissl M, Eikelenboom P, Grubeck-Loebenstein B. Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes. Neurobiol Dis. 2000;7(6 pt B):682-689.
-
(2000)
Neurobiol Dis
, vol.7
, Issue.6
, pp. 682-689
-
-
Blasko, I.1
Veerhuis, R.2
Stampfer-Kountchev, M.3
Saurwein-Teissl, M.4
Eikelenboom, P.5
Grubeck-Loebenstein, B.6
-
48
-
-
71849113134
-
Increased hippocampal neurogenesis in the progressive stage of Alzheimer’s disease phenotype in an APP/PS1 double transgenic mouse model
-
Yu Y, He J, Zhang Y, et al. Increased hippocampal neurogenesis in the progressive stage of Alzheimer’s disease phenotype in an APP/PS1 double transgenic mouse model. Hippocampus. 2009;19(12):1247-1253.
-
(2009)
Hippocampus
, vol.19
, Issue.12
, pp. 1247-1253
-
-
Yu, Y.1
He, J.2
Zhang, Y.3
-
49
-
-
67049171648
-
Neuronal protein trafficking associated with Alzheimer disease: From APP and BACE1 to glutamate receptors
-
Tang BL. Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptors. Cell Adh Migr. 2009;3(1):118-128.
-
(2009)
Cell Adh Migr
, vol.3
, Issue.1
, pp. 118-128
-
-
Tang, B.L.1
-
50
-
-
0037440474
-
Astrocytic expression of the Alzheimer’s disease β-secretase (BACE1) is stimulus-dependent
-
Hartlage-Rübsamen M, Zeitschel U, Apelt J, et al. Astrocytic expression of the Alzheimer’s disease β-secretase (BACE1) is stimulus-dependent. Glia. 2003;41(2):169-179.
-
(2003)
Glia
, vol.41
, Issue.2
, pp. 169-179
-
-
Hartlage-Rübsamen, M.1
Zeitschel, U.2
Apelt, J.3
-
51
-
-
13244264935
-
Alzheimer’s disease β-secretase BACE1 is not a neuron-specific enzyme
-
Roßner S, Lange-Dohna C, Zeitschel U, Perez-Polo JR. Alzheimer’s disease β-secretase BACE1 is not a neuron-specific enzyme. J Neurochem. 2005;92(2):226-234.
-
(2005)
J Neurochem
, vol.92
, Issue.2
, pp. 226-234
-
-
Roßner, S.1
Lange-Dohna, C.2
Zeitschel, U.3
Perez-Polo, J.R.4
-
52
-
-
0032487575
-
Prominent expression of presenilin-1 in senile plaques and reactive astrocytes in Alzheimer’s disease brain
-
Weggen S, Diehlmann A, Buslei R, Beyreuther K, Bayer T. Prominent expression of presenilin-1 in senile plaques and reactive astrocytes in Alzheimer’s disease brain. Neuroreport. 1998;9(14):3279-3283.
-
(1998)
Neuroreport
, vol.9
, Issue.14
, pp. 3279-3283
-
-
Weggen, S.1
Diehlmann, A.2
Buslei, R.3
Beyreuther, K.4
Bayer, T.5
-
53
-
-
84939214551
-
The contribution of activated astrocytes to A beta production: Implications for Alzheimer’s disease pathogenesis
-
Zhao J, O’Connor T, Vassar R. The contribution of activated astrocytes to A beta production: implications for Alzheimer’s disease pathogenesis. J Neuroinflammation. 2011;2:8.
-
(2011)
J Neuroinflammation
, vol.2
, pp. 8
-
-
Zhao, J.1
O’Connor, T.2
Vassar, R.3
-
54
-
-
77953193048
-
Changes with age in the activities of β-secretase and the Aβ-degrading enzymes neprilysin, insulin-degrading enzyme and angiotensin-converting enzyme
-
Miners JS, Van Helmond Z, Kehoe PG, Love S. Changes with age in the activities of β-secretase and the Aβ-degrading enzymes neprilysin, insulin-degrading enzyme and angiotensin-converting enzyme. Brain Pathol. 2010;20(4):794-802.
-
(2010)
Brain Pathol
, vol.20
, Issue.4
, pp. 794-802
-
-
Miners, J.S.1
Van Helmond, Z.2
Kehoe, P.G.3
Love, S.4
-
55
-
-
0037468588
-
Aging-related down-regulation of neprilysin, a putative β-amyloid-degrading enzyme, in transgenic Tg2576 Alzheimer-like mouse brain is accompanied by an astroglial upregulation in the vicinity of β-amyloid plaques
-
Apelt J, Ach K, Schliebs R. Aging-related down-regulation of neprilysin, a putative β-amyloid-degrading enzyme, in transgenic Tg2576 Alzheimer-like mouse brain is accompanied by an astroglial upregulation in the vicinity of β-amyloid plaques. Neurosci Lett. 2003;339(3):183-186.
-
(2003)
Neurosci Lett
, vol.339
, Issue.3
, pp. 183-186
-
-
Apelt, J.1
Ach, K.2
Schliebs, R.3
-
56
-
-
84857782207
-
AP-2 beta regulates amyloid beta-protein stimulation of apolipoprotein E transcription in astrocytes
-
Rossello XS, Igbavboa U, Weisman GA, Sun GY, Wood WG. AP-2 beta regulates amyloid beta-protein stimulation of apolipoprotein E transcription in astrocytes. Brain Res. 2012;1444:87-95.
-
(2012)
Brain Res
, vol.1444
, pp. 87-95
-
-
Rossello, X.S.1
Igbavboa, U.2
Weisman, G.A.3
Sun, G.Y.4
Wood, W.G.5
-
57
-
-
70349425672
-
Astrocytic dysfunction: Insights on the role in neurodegeneration
-
Rossi D, Volterra A. Astrocytic dysfunction: insights on the role in neurodegeneration. Brain Res Bull. 2009;80(4):224-232.
-
(2009)
Brain Res Bull
, vol.80
, Issue.4
, pp. 224-232
-
-
Rossi, D.1
Volterra, A.2
-
58
-
-
84855930897
-
ELISA methodology to quantify astrocyte production of cytokines/chemokines in vitro
-
Qin H, Benveniste EN. ELISA methodology to quantify astrocyte production of cytokines/chemokines in vitro. Methods Mol Biol. 2012;2012(814):235-249.
-
(2012)
Methods Mol Biol
, vol.2012
, Issue.814
, pp. 235-249
-
-
Qin, H.1
Benveniste, E.N.2
-
59
-
-
84879732252
-
A beta induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
-
Talantova M, Sanz-Blasco S, Zhang X, et al. A beta induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proc Natl Acad Sci U S A. 2013;110(27):E2518-E2527.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.27
, pp. E2518-E2527
-
-
Talantova, M.1
Sanz-Blasco, S.2
Zhang, X.3
-
60
-
-
84866316014
-
Astrocyte senescence as a component of Alzheimer’s disease
-
Bhat R, Crowe EP, Bitto A, et al. Astrocyte senescence as a component of Alzheimer’s disease. PLoS One. 2012;7(9):e45069.
-
(2012)
PLoS One
, vol.7
, Issue.9
-
-
Bhat, R.1
Crowe, E.P.2
Bitto, A.3
-
61
-
-
84861687100
-
The role of astrocytes in amyloid beta-protein toxicity and clearance
-
Thal DR. The role of astrocytes in amyloid beta-protein toxicity and clearance. Exp Neurol. 2012;236(1):1-5.
-
(2012)
Exp Neurol
, vol.236
, Issue.1
, pp. 1-5
-
-
Thal, D.R.1
-
62
-
-
84869016768
-
Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer’s disease
-
Furman JL, Sama DM, Gant JC, et al. Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer’s disease. J Neurosci. 2012;32(46):16129-16140.
-
(2012)
J Neurosci
, vol.32
, Issue.46
, pp. 16129-16140
-
-
Furman, J.L.1
Sama, D.M.2
Gant, J.C.3
-
63
-
-
56549091431
-
The complexity of mitogen-activated protein kinases (MAPKs) made simple
-
Krishna M, Narang H. The complexity of mitogen-activated protein kinases (MAPKs) made simple. Cell Mol Life Sci. 2008;65(22):3525-3544.
-
(2008)
Cell Mol Life Sci
, vol.65
, Issue.22
, pp. 3525-3544
-
-
Krishna, M.1
Narang, H.2
-
64
-
-
32144436881
-
Regulation of cellular functions by the ERK5 signalling pathway
-
Wang X, Tournier C. Regulation of cellular functions by the ERK5 signalling pathway. Cell Signal. 2006;18(6):753-760.
-
(2006)
Cell Signal
, vol.18
, Issue.6
, pp. 753-760
-
-
Wang, X.1
Tournier, C.2
-
65
-
-
84860165740
-
Mammalian MAPK signal transduction pathways activated by stress and inflammation: A 10-year update
-
Kyriakis JM, Avruch J. Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. Physiol Rev. 2012;92(2):689-737.
-
(2012)
Physiol Rev
, vol.92
, Issue.2
, pp. 689-737
-
-
Kyriakis, J.M.1
Avruch, J.2
-
66
-
-
34247367950
-
In vivo functions of mitogen-activated protein kinases: Conclusions from knock-in and knock-out mice
-
Gerits N, Kostenko S, Moens U. In vivo functions of mitogen-activated protein kinases: conclusions from knock-in and knock-out mice. Transgenic Res. 2007;16(3):281-314.
-
(2007)
Transgenic Res
, vol.16
, Issue.3
, pp. 281-314
-
-
Gerits, N.1
Kostenko, S.2
Moens, U.3
-
67
-
-
67749117934
-
Signal integration by JNK and p38 MAPK pathways in cancer development
-
Wagner EF, Nebreda ÁR. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer. 2009;9(8):537-549.
-
(2009)
Nat Rev Cancer
, vol.9
, Issue.8
, pp. 537-549
-
-
Wagner, E.F.1
Nebreda, Á.R.2
-
68
-
-
84876434217
-
Implication of JNK pathway on tau pathology and cognitive decline in a senescence-accelerated mouse model
-
Orejana L, Barros-Minones L, Aguirre N, Puerta E. Implication of JNK pathway on tau pathology and cognitive decline in a senescence-accelerated mouse model. Exp Gerontol. 2013;48(6):565-571.
-
(2013)
Exp Gerontol
, vol.48
, Issue.6
, pp. 565-571
-
-
Orejana, L.1
Barros-Minones, L.2
Aguirre, N.3
Puerta, E.4
-
69
-
-
83755171439
-
c-Jun N-terminal kinase regulates soluble A beta oligomers and cognitive impairment in AD mouse model
-
Sclip A, Antoniou X, Colombo A, et al. c-Jun N-terminal kinase regulates soluble A beta oligomers and cognitive impairment in AD mouse model. J Biol Chem. 2011;286(51):43871-43880.
-
(2011)
J Biol Chem
, vol.286
, Issue.51
, pp. 43871-43880
-
-
Sclip, A.1
Antoniou, X.2
Colombo, A.3
-
70
-
-
0034727889
-
JNK activation is associated with intracellular β-amyloid accumulation
-
Shoji M, Iwakami N, Takeuchi S, et al. JNK activation is associated with intracellular β-amyloid accumulation. Mol Brain Res. 2000;85(1):221-233.
-
(2000)
Mol Brain Res
, vol.85
, Issue.1
, pp. 221-233
-
-
Shoji, M.1
Iwakami, N.2
Takeuchi, S.3
-
71
-
-
84885695172
-
The role of TLR2/JNK/NF-kappa B pathway in amyloid beta peptide-induced inflammatory response in mouse NG108-15 neural cells
-
Lin W, Ding M, Xue J, Leng W. The role of TLR2/JNK/NF-kappa B pathway in amyloid beta peptide-induced inflammatory response in mouse NG108-15 neural cells. Int Immunopharmacol. 2013;17(3):880-884.
-
(2013)
Int Immunopharmacol
, vol.17
, Issue.3
, pp. 880-884
-
-
Lin, W.1
Ding, M.2
Xue, J.3
Leng, W.4
-
72
-
-
73449131129
-
Targeting p38 MAPK pathway for the treatment of Alzheimer’s disease
-
Munoz L, Ammit AJ. Targeting p38 MAPK pathway for the treatment of Alzheimer’s disease. Neuropharmacology. 2010;58(3):561-568.
-
(2010)
Neuropharmacology
, vol.58
, Issue.3
, pp. 561-568
-
-
Munoz, L.1
Ammit, A.J.2
-
73
-
-
0033911179
-
p38 MAP kinase regulates TNF-α production in human astrocytes and microglia by multiple mechanisms
-
Lee YB, Schrader JW, Kim SU. p38 MAP kinase regulates TNF-α production in human astrocytes and microglia by multiple mechanisms. Cytokine. 2000;12(7):874-880.
-
(2000)
Cytokine
, vol.12
, Issue.7
, pp. 874-880
-
-
Lee, Y.B.1
Schrader, J.W.2
Kim, S.U.3
-
74
-
-
41149177024
-
Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt
-
Xing B, Xin T, Hunter RL, Bing G. Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt. J Neuroinflammation. 2008;5(4):1-11.
-
(2008)
J Neuroinflammation
, vol.5
, Issue.4
, pp. 1-11
-
-
Xing, B.1
Xin, T.2
Hunter, R.L.3
Bing, G.4
-
75
-
-
0036968944
-
β-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: Involvement of the p38MAPK pathway
-
Giovannini MG, Scali C, Prosperi C, et al. β-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway. Neurobiol Dis. 2002;11(2):257-274.
-
(2002)
Neurobiol Dis
, vol.11
, Issue.2
, pp. 257-274
-
-
Giovannini, M.G.1
Scali, C.2
Prosperi, C.3
-
76
-
-
53949085542
-
Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades
-
Matos M, Augusto E, Oliveira C, Agostinho P. Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: involvement of oxidative stress and mitogen-activated protein kinase cascades. Neuroscience. 2008;156(4):898-910.
-
(2008)
Neuroscience
, vol.156
, Issue.4
, pp. 898-910
-
-
Matos, M.1
Augusto, E.2
Oliveira, C.3
Agostinho, P.4
-
77
-
-
33745852641
-
C-Jun N-terminal kinase (JNK) regulation of iNOS expression in glial cells: Predominant role of JNK1 isoform
-
Pawate S, Bhat NR. C-Jun N-terminal kinase (JNK) regulation of iNOS expression in glial cells: predominant role of JNK1 isoform. Antioxid Redox Signal. 2006;8(5-6):903-909.
-
(2006)
Antioxid Redox Signal
, vol.8
, Issue.5-6
, pp. 903-909
-
-
Pawate, S.1
Bhat, N.R.2
-
78
-
-
0037440375
-
Cytokine-stimulated inducible nitric oxide synthase expression in astroglia: Role of Erk mitogen-activated protein kinase and NF-κB
-
Marcus JS, Karackattu SL, Fleegal MA, Sumners C. Cytokine-stimulated inducible nitric oxide synthase expression in astroglia: role of Erk mitogen-activated protein kinase and NF-κB. Glia. 2003;41(2):152-160.
-
(2003)
Glia
, vol.41
, Issue.2
, pp. 152-160
-
-
Marcus, J.S.1
Karackattu, S.L.2
Fleegal, M.A.3
Sumners, C.4
-
79
-
-
84862871522
-
Control of JNK for an activation of NADPH oxidase in LPS-stimulated BV2 microglia
-
Han JE, Choi JW. Control of JNK for an activation of NADPH oxidase in LPS-stimulated BV2 microglia. Arch Pharm Res. 2012;35(4):709-715.
-
(2012)
Arch Pharm Res
, vol.35
, Issue.4
, pp. 709-715
-
-
Han, J.E.1
Choi, J.W.2
-
80
-
-
84875727718
-
Inhibition of phosphorylation of JNK suppresses A beta-induced ER stress and upregulates prosurvival mitochondrial proteins in rat hippocampus
-
Yenki P, Khodagholi F, Shaerzadeh F. Inhibition of phosphorylation of JNK suppresses A beta-induced ER stress and upregulates prosurvival mitochondrial proteins in rat hippocampus. J Mol Neurosci. 2013;49(2):262-269.
-
(2013)
J Mol Neurosci
, vol.49
, Issue.2
, pp. 262-269
-
-
Yenki, P.1
Khodagholi, F.2
Shaerzadeh, F.3
-
81
-
-
84875660794
-
Interferon-alpha induces nitric oxide synthase expression and haem oxygenase-1 down-regulation in microglia: Implications of cellular mechanism of IFN-alpha-induced depression
-
Lu D-Y, Leung Y-M, Su K-P. Interferon-alpha induces nitric oxide synthase expression and haem oxygenase-1 down-regulation in microglia: implications of cellular mechanism of IFN-alpha-induced depression. Int J Neuropsychopharmacol. 2013;16(2):433-444.
-
(2013)
Int J Neuropsychopharmacol
, vol.16
, Issue.2
, pp. 433-444
-
-
Lu, D.-Y.1
Leung, Y.-M.2
Su, K.-P.3
-
82
-
-
84874024590
-
Deficiency in p38beta MAPK fails to inhibit cytokine production or protect neurons against inflammatory insult in in vitro and in vivo mouse models
-
Xing B, Bachstetter AD, Van Eldik LJ. Deficiency in p38beta MAPK fails to inhibit cytokine production or protect neurons against inflammatory insult in in vitro and in vivo mouse models. PloS One. 2013;8(2):e56852-e56852.
-
(2013)
PloS One
, vol.8
, Issue.2
, pp. e56852-e56852
-
-
Xing, B.1
Bachstetter, A.D.2
Van Eldik, L.J.3
-
83
-
-
0346037264
-
JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins
-
Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M. JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev Cell. 2003;4(4):521-533.
-
(2003)
Dev Cell
, vol.4
, Issue.4
, pp. 521-533
-
-
Chang, L.1
Jones, Y.2
Ellisman, M.H.3
Goldstein, L.S.4
Karin, M.5
-
84
-
-
36448936747
-
Kinase activities increase during the development of tauopathy in htau mice
-
Kelleher I, Garwood C, Hanger DP, Anderton BH, Noble W. Kinase activities increase during the development of tauopathy in htau mice. J Neurochem. 2007;103(6):2256-2267.
-
(2007)
J Neurochem
, vol.103
, Issue.6
, pp. 2256-2267
-
-
Kelleher, I.1
Garwood, C.2
Hanger, D.P.3
Anderton, B.H.4
Noble, W.5
-
85
-
-
70349336861
-
Green tea (-)-epigallocatechin-3-gallate inhibits beta-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-kappa B pathways in mice
-
Lee JW, Lee YK, Ban JO, et al. Green tea (-)-epigallocatechin-3-gallate inhibits beta-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-kappa B pathways in mice. J Nutr. 2009;139(10):1987-1993.
-
(2009)
J Nutr
, vol.139
, Issue.10
, pp. 1987-1993
-
-
Lee, J.W.1
Lee, Y.K.2
Ban, J.O.3
-
86
-
-
34547700243
-
Epigallocatechin-3-gallate suppresses NF-kappa B activation and phosphorylation of p38 MAPK and JNK in human astrocytoma U373MG cells
-
Kim SJ, Jeong HJ, Lee KM, et al. Epigallocatechin-3-gallate suppresses NF-kappa B activation and phosphorylation of p38 MAPK and JNK in human astrocytoma U373MG cells. J Nutr Biochem. 2007;18(9):587-596.
-
(2007)
J Nutr Biochem
, vol.18
, Issue.9
, pp. 587-596
-
-
Kim, S.J.1
Jeong, H.J.2
Lee, K.M.3
-
87
-
-
0036270560
-
Regulation of tumor necrosis factor-α expression by CD40 ligation in BV-2 microglial cells
-
Jana M, Dasgupta S, Liu X, Pahan K. Regulation of tumor necrosis factor-α expression by CD40 ligation in BV-2 microglial cells. J Neurochem. 2002;80(1):197-206.
-
(2002)
J Neurochem
, vol.80
, Issue.1
, pp. 197-206
-
-
Jana, M.1
Dasgupta, S.2
Liu, X.3
Pahan, K.4
-
88
-
-
33646588324
-
Differential suppression of endotoxin-inducible inflammatory cytokines by nuclear factor kappa B (NFκB) inhibitor in rat microglia
-
Nakajima K, Matsushita Y, Tohyama Y, Kohsaka S, Kurihara T. Differential suppression of endotoxin-inducible inflammatory cytokines by nuclear factor kappa B (NFκB) inhibitor in rat microglia. Neurosci Lett. 2006;401(3):199-202.
-
(2006)
Neurosci Lett
, vol.401
, Issue.3
, pp. 199-202
-
-
Nakajima, K.1
Matsushita, Y.2
Tohyama, Y.3
Kohsaka, S.4
Kurihara, T.5
-
89
-
-
0037119464
-
p38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells roles of nuclear factors, nuclear factor κB, cAMP response element-binding protein, CCAAT/enhance-binding protein-β, and activating transcription factor-2
-
Bhat NR, Feinstein DL, Shen Q, Bhat AN. p38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells roles of nuclear factors, nuclear factor κB, cAMP response element-binding protein, CCAAT/enhance-binding protein-β, and activating transcription factor-2. J Biol Chem. 2002;277(33):29584-29592.
-
(2002)
J Biol Chem
, vol.277
, Issue.33
, pp. 29584-29592
-
-
Bhat, N.R.1
Feinstein, D.L.2
Shen, Q.3
Bhat, A.N.4
-
90
-
-
33646246179
-
Triptolide inhibits COX-2 expression via NF-kappa B pathway in astrocytes
-
Dai Y-Q, Jin D-Z, Zhu X-Z, Lei D-L. Triptolide inhibits COX-2 expression via NF-kappa B pathway in astrocytes. Neurosci Res. 2006;55(2):154-160.
-
(2006)
Neurosci Res
, vol.55
, Issue.2
, pp. 154-160
-
-
Dai, Y.-Q.1
Jin, D.-Z.2
Zhu, X.-Z.3
Lei, D.-L.4
-
91
-
-
0034651101
-
Inflammatory mechanisms in Alzheimer’s disease: Inhibition of β-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARγ agonists
-
Combs CK, Johnson DE, Karlo JC, Cannady SB, Landreth GE. Inflammatory mechanisms in Alzheimer’s disease: inhibition of β-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARγ agonists. J Neurosci. 2000;20(2):558-567.
-
(2000)
J Neurosci
, vol.20
, Issue.2
, pp. 558-567
-
-
Combs, C.K.1
Johnson, D.E.2
Karlo, J.C.3
Cannady, S.B.4
Landreth, G.E.5
-
92
-
-
46749115113
-
PPARγ agonists as therapeutics for the treatment of Alzheimer’s disease
-
Landreth G, Jiang Q, Mandrekar S, Heneka M. PPARγ agonists as therapeutics for the treatment of Alzheimer’s disease. Neurotherapeutics. 2008;5(3):481-489.
-
(2008)
Neurotherapeutics
, vol.5
, Issue.3
, pp. 481-489
-
-
Landreth, G.1
Jiang, Q.2
Mandrekar, S.3
Heneka, M.4
-
93
-
-
0022481133
-
Multiple nuclear factors interact with the immunoglobulin enhancer sequences
-
Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell. 1986;46(5):705-716.
-
(1986)
Cell
, vol.46
, Issue.5
, pp. 705-716
-
-
Sen, R.1
Baltimore, D.2
-
94
-
-
38849199203
-
Shared principles in NF-κB signaling
-
Hayden MS, Ghosh S. Shared principles in NF-κB signaling. Cell. 2008;132(3):344-362.
-
(2008)
Cell
, vol.132
, Issue.3
, pp. 344-362
-
-
Hayden, M.S.1
Ghosh, S.2
-
95
-
-
84877824588
-
NF-κB signaling pathways role in nervous system physiology and pathology
-
Mincheva-Tasheva S, Soler RM. NF-κB signaling pathways role in nervous system physiology and pathology. Neuroscientist. 2013;19(2):175-194.
-
(2013)
Neuroscientist
, vol.19
, Issue.2
, pp. 175-194
-
-
Mincheva-Tasheva, S.1
Soler, R.M.2
-
96
-
-
84880779328
-
Induction of an inflammatory loop by interleukin-1 beta and tumor necrosis factor-alpha involves NF-kappa B and STAT-1 in differentiated human neuroprogenitor cells
-
Pugazhenthi S, Zhang Y, Bouchard R, Mahaffey G. Induction of an inflammatory loop by interleukin-1 beta and tumor necrosis factor-alpha involves NF-kappa B and STAT-1 in differentiated human neuroprogenitor cells. PLoS One. 2013;8(7):e69585.
-
(2013)
PLoS One
, vol.8
, Issue.7
-
-
Pugazhenthi, S.1
Zhang, Y.2
Bouchard, R.3
Mahaffey, G.4
-
97
-
-
54849410809
-
Complementary roles of tumor necrosis factor alpha and interferon gamma in inducible microglial nitric oxide generation
-
Mir M, Tolosa L, Asensio VJ, Lladó J, Olmos G. Complementary roles of tumor necrosis factor alpha and interferon gamma in inducible microglial nitric oxide generation. J Neuroimmunol. 2008;204(1):101-109.
-
(2008)
J Neuroimmunol
, vol.204
, Issue.1
, pp. 101-109
-
-
Mir, M.1
Tolosa, L.2
Asensio, V.J.3
Lladó, J.4
Olmos, G.5
-
98
-
-
77249129746
-
Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior
-
Koo JW, Russo SJ, Ferguson D, Nestler EJ, Duman RS. Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc Natl Acad Sci U S A. 2010;107(6):2669-2674.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.6
, pp. 2669-2674
-
-
Koo, J.W.1
Russo, S.J.2
Ferguson, D.3
Nestler, E.J.4
Duman, R.S.5
-
99
-
-
0035139792
-
Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer
-
Yamamoto Y, Gaynor RB. Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer. J Clin Invest. 2001;107(2):135-142.
-
(2001)
J Clin Invest
, vol.107
, Issue.2
, pp. 135-142
-
-
Yamamoto, Y.1
Gaynor, R.B.2
-
100
-
-
0030222080
-
Induction of neuroprotective κB-dependent transcription by secreted forms of the Alzheimer’s β-amyloid precursor
-
Barger SW, Mattson MP. Induction of neuroprotective κB-dependent transcription by secreted forms of the Alzheimer’s β-amyloid precursor. Mol Brain Res. 1996;40(1):116-126.
-
(1996)
Mol Brain Res
, vol.40
, Issue.1
, pp. 116-126
-
-
Barger, S.W.1
Mattson, M.P.2
-
101
-
-
44349140124
-
NFκB-dependent control of BACE1 promoter transactivation by Aβ42
-
Buggia-Prevot V, Sevalle J, Rossner S, Checler F. NFκB-dependent control of BACE1 promoter transactivation by Aβ42. J Biol Chem. 2008;283(15):10037-10047.
-
(2008)
J Biol Chem
, vol.283
, Issue.15
, pp. 10037-10047
-
-
Buggia-Prevot, V.1
Sevalle, J.2
Rossner, S.3
Checler, F.4
-
102
-
-
33645461302
-
NF-κB pathway: A target for preventing β-amyloid (Aβ)-induced neuronal damage and Aβ42 production
-
Valerio A, Boroni F, Benarese M, et al. NF-κB pathway: a target for preventing β-amyloid (Aβ)-induced neuronal damage and Aβ42 production. Eur J Neurosci. 2006;23(7):1711-1720.
-
(2006)
Eur J Neurosci
, vol.23
, Issue.7
, pp. 1711-1720
-
-
Valerio, A.1
Boroni, F.2
Benarese, M.3
-
103
-
-
84856428468
-
Increased NF-kappa B signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer’s disease
-
Chen CH, Zhou W, Liu S, et al. Increased NF-kappa B signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer’s disease. Int J Neuropsychopharmacol. 2012;15(1):77-90.
-
(2012)
Int J Neuropsychopharmacol
, vol.15
, Issue.1
, pp. 77-90
-
-
Chen, C.H.1
Zhou, W.2
Liu, S.3
-
104
-
-
76649092343
-
Expression of the apoptosis-related proteins caspase-3 and NF-κB in the hippocampus of Tg2576 mice
-
Niu YL, Zhang WJ, Wu P, et al. Expression of the apoptosis-related proteins caspase-3 and NF-κB in the hippocampus of Tg2576 mice. Neurosci Bull. 2010;26(1):37-46.
-
(2010)
Neurosci Bull
, vol.26
, Issue.1
, pp. 37-46
-
-
Niu, Y.L.1
Zhang, W.J.2
Wu, P.3
-
105
-
-
84863798868
-
Nuclear factor-kappa B regulates beta APP and beta-and gamma-secretases differently at physiological and supraphysiological A beta concentrations
-
Chami L, Buggia-Prévot V, Duplan E, et al. Nuclear factor-kappa B regulates beta APP and beta-and gamma-secretases differently at physiological and supraphysiological A beta concentrations. J Biol Chem. 2012;287(29):24573-24584.
-
(2012)
J Biol Chem
, vol.287
, Issue.29
, pp. 24573-24584
-
-
Chami, L.1
Buggia-Prévot, V.2
Duplan, E.3
-
106
-
-
33847627937
-
Inhibition of Aβ production by NF-κB inhibitors
-
Paris D, Patel N, Quadros A, et al. Inhibition of Aβ production by NF-κB inhibitors. Neurosci Lett. 2007;415(1):11-16.
-
(2007)
Neurosci Lett
, vol.415
, Issue.1
, pp. 11-16
-
-
Paris, D.1
Patel, N.2
Quadros, A.3
-
107
-
-
9644275598
-
Modulation of nuclear factor-κB activity by indomethacin influences Aβ levels but not Aβ precursor protein metabolism in a model of Alzheimer’s disease
-
Sung S, Yang H, Uryu K, et al. Modulation of nuclear factor-κB activity by indomethacin influences Aβ levels but not Aβ precursor protein metabolism in a model of Alzheimer’s disease. Am J Pathol. 2004;165(6):2197-2206.
-
(2004)
Am J Pathol
, vol.165
, Issue.6
, pp. 2197-2206
-
-
Sung, S.1
Yang, H.2
Uryu, K.3
-
108
-
-
84856452782
-
Dysregulated NF-kappa B pathway in peripheral mononuclear cells of Alzheimer’s disease patients
-
Ascolani A, Balestrieri E, Minutolo A, et al. Dysregulated NF-kappa B pathway in peripheral mononuclear cells of Alzheimer’s disease patients. Curr Alzheimer Res. 2012;9(1):128-137.
-
(2012)
Curr Alzheimer Res
, vol.9
, Issue.1
, pp. 128-137
-
-
Ascolani, A.1
Balestrieri, E.2
Minutolo, A.3
-
109
-
-
48749127970
-
PPARs in Alzheimer’s disease
-
Kummer MP, Heneka MT. PPARs in Alzheimer’s disease. PPAR Res. 2008;2008:403896.
-
(2008)
PPAR Res
, vol.2008
-
-
Kummer, M.P.1
Heneka, M.T.2
-
110
-
-
36949009469
-
Peroxisome proliferator activated receptors and lipoprotein metabolism
-
Kersten S. Peroxisome proliferator activated receptors and lipoprotein metabolism. PPAR Res. 2007;2008:132960.
-
(2007)
PPAR Res
, vol.2008
-
-
Kersten, S.1
-
111
-
-
47949094965
-
Integration of metabolism and inflammation by lipid-activated nuclear receptors
-
Bensinger SJ, Tontonoz P. Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature. 2008;454(7203):470-477.
-
(2008)
Nature
, vol.454
, Issue.7203
, pp. 470-477
-
-
Bensinger, S.J.1
Tontonoz, P.2
-
112
-
-
33747154772
-
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network
-
Bookout AL, Jeong Y, Downes M, Yu RT, Evans RM, Mangelsdorf DJ. Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell. 2006;126(4):789-799.
-
(2006)
Cell
, vol.126
, Issue.4
, pp. 789-799
-
-
Bookout, A.L.1
Jeong, Y.2
Downes, M.3
Yu, R.T.4
Evans, R.M.5
Mangelsdorf, D.J.6
-
113
-
-
33746238205
-
Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer’s disease
-
de la Monte SM, Wands JR. Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer’s disease. J Alzheimer Dis. 2006;9(2):167-181.
-
(2006)
J Alzheimer Dis
, vol.9
, Issue.2
, pp. 167-181
-
-
de la Monte, S.M.1
Wands, J.R.2
-
114
-
-
84868121739
-
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) and neurodegenerative disorders
-
Chen YC, Wu JS, Tsai HD, et al. Peroxisome proliferator-activated receptor gamma (PPAR-gamma) and neurodegenerative disorders. Mol Neurobiol. 2012;46(1):114-124.
-
(2012)
Mol Neurobiol
, vol.46
, Issue.1
, pp. 114-124
-
-
Chen, Y.C.1
Wu, J.S.2
Tsai, H.D.3
-
115
-
-
33744962510
-
Peroxisome proliferator-activated receptor γ-mediated regulation of neural stem cell proliferation and differentiation
-
Wada K, Nakajima A, Katayama K, et al. Peroxisome proliferator-activated receptor γ-mediated regulation of neural stem cell proliferation and differentiation. J Biol Chem. 2006;281(18):12673-12681.
-
(2006)
J Biol Chem
, vol.281
, Issue.18
, pp. 12673-12681
-
-
Wada, K.1
Nakajima, A.2
Katayama, K.3
-
117
-
-
82655189157
-
Cannabidiol reduces Ab-induced neuroinflammation and promotes hippocampal neurogenesis through PPAR gamma involvement
-
Esposito G, Scuderi C, Valenza M, et al. Cannabidiol reduces Ab-induced neuroinflammation and promotes hippocampal neurogenesis through PPAR gamma involvement. PLoS One. 2011;6(12):e28668.
-
(2011)
PLoS One
, vol.6
, Issue.12
-
-
Esposito, G.1
Scuderi, C.2
Valenza, M.3
-
118
-
-
34147102288
-
Therapeutic use of agonists of the nuclear receptor PPAR in Alzheimers disease
-
Landreth G. Therapeutic use of agonists of the nuclear receptor PPAR in Alzheimers disease. Curr Alzheimer Res. 2007;4(2):159-164.
-
(2007)
Curr Alzheimer Res
, vol.4
, Issue.2
, pp. 159-164
-
-
Landreth, G.1
-
119
-
-
53549097355
-
Insulin resistance and Alzheimer’s disease: Molecular links clinical implications
-
Neumann KF, Rojo L, Navarrete LP, Farías G, Reyes P, Maccioni RB. Insulin resistance and Alzheimer’s disease: molecular links clinical implications. Curr Alzheimer Res. 2008;5(5):438-447.
-
(2008)
Curr Alzheimer Res
, vol.5
, Issue.5
, pp. 438-447
-
-
Neumann, K.F.1
Rojo, L.2
Navarrete, L.P.3
Farías, G.4
Reyes, P.5
McCioni, R.B.6
-
120
-
-
36949038203
-
The role of peroxisome proliferator-activated receptor-γ PPARγ) in Alzheimer’s disease
-
Jiang Q, Heneka M, Landreth GE. The role of peroxisome proliferator-activated receptor-γ PPARγ) in Alzheimer’s disease. CNS Drugs. 2008;22(1):1-14.
-
(2008)
CNS Drugs
, vol.22
, Issue.1
, pp. 1-14
-
-
Jiang, Q.1
Heneka, M.2
Landreth, G.E.3
-
121
-
-
84877654967
-
Peroxisome proliferator-activated receptor (PPAR) gamma and PPAR alpha agonists modulate mitochondrial fusion-fission dynamics: Relevance to reactive oxygen species (ROS)-related neurodegenerative disorders?
-
Zolezzi JM, Silva-Alvarez C, Ordenes D, et al. Peroxisome proliferator-activated receptor (PPAR) gamma and PPAR alpha agonists modulate mitochondrial fusion-fission dynamics: relevance to reactive oxygen species (ROS)-related neurodegenerative disorders? PLoS One. 2013;8(5):e64019.
-
(2013)
PLoS One
, vol.8
, Issue.5
-
-
Zolezzi, J.M.1
Silva-Alvarez, C.2
Ordenes, D.3
-
122
-
-
20444499367
-
Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1-42 levels in APPV717I transgenic mice
-
Heneka MT, Sastre M, Dumitrescu-Ozimek L, et al. Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1-42 levels in APPV717I transgenic mice. Brain. 2005;128(6):1442-1453.
-
(2005)
Brain
, vol.128
, Issue.6
, pp. 1442-1453
-
-
Heneka, M.T.1
Sastre, M.2
Dumitrescu-Ozimek, L.3
-
123
-
-
84859349600
-
The PPAR-gamma agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function
-
Gray E, Ginty M, Kemp K, Scolding N, Wilkins A. The PPAR-gamma agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function. J Neuroinflammation. 2012;5:9.
-
(2012)
J Neuroinflammation
, vol.5
, pp. 9
-
-
Gray, E.1
Ginty, M.2
Kemp, K.3
Scolding, N.4
Wilkins, A.5
-
124
-
-
33746396694
-
Troglitazone, a peroxisome proliferator-activated receptor-γ agonist, decreases tau phosphorylation in CHOtau4R cells
-
d’Abramo C, Ricciarelli R, Pronzato MA, Davies P. Troglitazone, a peroxisome proliferator-activated receptor-γ agonist, decreases tau phosphorylation in CHOtau4R cells. J Neurochem. 2006;98(4):1068-1077.
-
(2006)
J Neurochem
, vol.98
, Issue.4
, pp. 1068-1077
-
-
d’Abramo, C.1
Ricciarelli, R.2
Pronzato, M.A.3
Davies, P.4
-
125
-
-
79955667671
-
Effects of chronic systemic treatment with peroxisome proliferator-activated receptor alpha activators on neuroinflammation induced by intracerebral injection of lipopolysaccharide in adult mice
-
Wang G, Namura S. Effects of chronic systemic treatment with peroxisome proliferator-activated receptor alpha activators on neuroinflammation induced by intracerebral injection of lipopolysaccharide in adult mice. Neurosci Res. 2011;70(2):230-237.
-
(2011)
Neurosci Res
, vol.70
, Issue.2
, pp. 230-237
-
-
Wang, G.1
Namura, S.2
-
126
-
-
84858972381
-
PPAR delta prevents radiation-induced proinflammatory responses in microglia via transrepression of NF-kappa B and inhibition of the PK alpha/MEK1/2/ERK1/2/AP-1 pathway
-
Schnegg CI, Kooshki M, Hsu F-C, Sui G, Robbins ME. PPAR delta prevents radiation-induced proinflammatory responses in microglia via transrepression of NF-kappa B and inhibition of the PK alpha/MEK1/2/ERK1/2/AP-1 pathway. Free Radic Biol Med. 2012;52(9):1734-1743.
-
(2012)
Free Radic Biol Med
, vol.52
, Issue.9
, pp. 1734-1743
-
-
Schnegg, C.I.1
Kooshki, M.2
Hsu, F.-C.3
Sui, G.4
Robbins, M.E.5
-
127
-
-
84877340453
-
Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPAR beta/delta-null mice
-
Barroso E, del Valle J, Porquet D, et al. Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPAR beta/delta-null mice. Biochim Biophys Acta. 2013;1832(8):1241-1248.
-
(2013)
Biochim Biophys Acta
, vol.1832
, Issue.8
, pp. 1241-1248
-
-
Barroso, E.1
del Valle, J.2
Porquet, D.3
-
128
-
-
84863299227
-
Tumor necrosis factor and Alzheimer’s disease: A cause and consequence relationship
-
Sharma V, Thakur V, Singh SN, Guleria R. Tumor necrosis factor and Alzheimer’s disease: a cause and consequence relationship. Klinik Psikofarmakoloji B. 2012;22(1):86-97.
-
(2012)
Klinik Psikofarmakoloji B
, vol.22
, Issue.1
, pp. 86-97
-
-
Sharma, V.1
Thakur, V.2
Singh, S.N.3
Guleria, R.4
-
129
-
-
78049419440
-
A meta-analysis of cytokines in Alzheimer’s disease
-
Swardfager W, Lanctôt K, Rothenburg L, Wong A, Cappell J, Herrmann N. A meta-analysis of cytokines in Alzheimer’s disease. Biol Psychiatry. 2010;68(10):930-941.
-
(2010)
Biol Psychiatry
, vol.68
, Issue.10
, pp. 930-941
-
-
Swardfager, W.1
Lanctôt, K.2
Rothenburg, L.3
Wong, A.4
Cappell, J.5
Herrmann, N.6
-
130
-
-
84883187048
-
BDNF, TNF alpha, HSP90, CFH, and IL-10 serum levels in patients with early or late onset Alzheimer’s disease or mild cognitive impairment
-
Gezen-Ak D, Dursun E, Hanağası H, et al. BDNF, TNF alpha, HSP90, CFH, and IL-10 serum levels in patients with early or late onset Alzheimer’s disease or mild cognitive impairment. J Alzheimers Dis. 2013;37(1):185-195.
-
(2013)
J Alzheimers Dis
, vol.37
, Issue.1
, pp. 185-195
-
-
Gezen-Ak, D.1
Dursun, E.2
Hanağası, H.3
-
131
-
-
62249094525
-
Inhibition of soluble TNF signaling in a mouse model of Alzheimer’s disease prevents pre-plaque amyloid-associated neuropathology
-
McAlpine FE, Lee JK, Harms AS, et al. Inhibition of soluble TNF signaling in a mouse model of Alzheimer’s disease prevents pre-plaque amyloid-associated neuropathology. Neurobiol Dis. 2009;34(1):163-177.
-
(2009)
Neurobiol Dis
, vol.34
, Issue.1
, pp. 163-177
-
-
McAlpine, F.E.1
Lee, J.K.2
Harms, A.S.3
-
132
-
-
33947512432
-
Interferon-γ and tumor necrosis factor-α regulate amyloid-β plaque deposition and β-secretase expression in Swedish mutant APP transgenic mice
-
Yamamoto M, Kiyota T, Horiba M, et al. Interferon-γ and tumor necrosis factor-α regulate amyloid-β plaque deposition and β-secretase expression in Swedish mutant APP transgenic mice. Am J Pathol. 2007;170(2):680-692.
-
(2007)
Am J Pathol
, vol.170
, Issue.2
, pp. 680-692
-
-
Yamamoto, M.1
Kiyota, T.2
Horiba, M.3
-
133
-
-
10344238086
-
Tumor necrosis factor-α, interleukin-1β, and interferon-γ stimulate γ-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway
-
Liao Y-F, Wang B-J, Cheng H-T, Kuo L-H, Wolfe MS. Tumor necrosis factor-α, interleukin-1β, and interferon-γ stimulate γ-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway. J Biol Chem. 2004;279(47):49523-49532.
-
(2004)
J Biol Chem
, vol.279
, Issue.47
, pp. 49523-49532
-
-
Liao, Y.-F.1
Wang, B.-J.2
Cheng, H.-T.3
Kuo, L.-H.4
Wolfe, M.S.5
-
134
-
-
84861473274
-
Tumor necrosis factor-alpha synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease
-
Tweedie D, Ferguson RA, Fishman K, et al. Tumor necrosis factor-alpha synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease. J Neuroinflammation. 2012;29:9.
-
(2012)
J Neuroinflammation
, vol.29
, pp. 9
-
-
Tweedie, D.1
Ferguson, R.A.2
Fishman, K.3
-
135
-
-
84862883254
-
Levels of amyloid beta-42, interleukin-6 and tumor necrosis factor-alpha in Alzheimer’s disease and vascular dementia
-
Uslu S, Akarkarasu ZE, Ozbabalik D, et al. Levels of amyloid beta-42, interleukin-6 and tumor necrosis factor-alpha in Alzheimer’s disease and vascular dementia. Neurochem Res. 2012;37(7):1554-1559.
-
(2012)
Neurochem Res
, vol.37
, Issue.7
, pp. 1554-1559
-
-
Uslu, S.1
Akarkarasu, Z.E.2
Ozbabalik, D.3
-
136
-
-
33644862228
-
Interleukin 1 genetics, inflammatory mechanisms, and nutrigenetic opportunities to modulate diseases of aging
-
Kornman KS. Interleukin 1 genetics, inflammatory mechanisms, and nutrigenetic opportunities to modulate diseases of aging. Am J Clin Nutr. 2006;83(2):475S-483S.
-
(2006)
Am J Clin Nutr
, vol.83
, Issue.2
, pp. 475S-483S
-
-
Kornman, K.S.1
-
137
-
-
84873567043
-
Increased systemic inflammatory interleukin-1 beta and interleukin-6 during agitation as predictors of Alzheimer’s disease
-
Honma T, Hatta K, Hitomi Y, et al. Increased systemic inflammatory interleukin-1 beta and interleukin-6 during agitation as predictors of Alzheimer’s disease. Int J Geriatr Psychiatry. 2013;28(3):233-241.
-
(2013)
Int J Geriatr Psychiatry
, vol.28
, Issue.3
, pp. 233-241
-
-
Honma, T.1
Hatta, K.2
Hitomi, Y.3
-
138
-
-
84860833662
-
Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer’s disease
-
Payão SL, Gonçalves GM, de Labio RW, et al. Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer’s disease. J Neuroimmunol. 2012;247(1-2):59-62.
-
(2012)
J Neuroimmunol
, vol.247
, Issue.1-2
, pp. 59-62
-
-
Payão, S.L.1
Gonçalves, G.M.2
de Labio, R.W.3
-
139
-
-
0033525735
-
Translation of the Alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5′-untranslated region sequences
-
Rogers JT, Leiter LM, McPhee J, et al. Translation of the Alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5′-untranslated region sequences. J Biol Chem. 1999;274(10):6421-6431.
-
(1999)
J Biol Chem
, vol.274
, Issue.10
, pp. 6421-6431
-
-
Rogers, J.T.1
Leiter, L.M.2
McPhee, J.3
-
140
-
-
83455213559
-
Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors
-
Liu L, Aboud O, Jones RA, Mrak RE, Griffin S, Barger SW. Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors. J Neuroinflammation. 2011;8:175.
-
(2011)
J Neuroinflammation
, vol.8
, pp. 175
-
-
Liu, L.1
Aboud, O.2
Jones, R.A.3
Mrak, R.E.4
Griffin, S.5
Barger, S.W.6
-
141
-
-
0034814057
-
Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer’s disease: Potential significance for tau protein phosphorylation
-
Sheng JG, Jones RA, Zhou XQ, et al. Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer’s disease: potential significance for tau protein phosphorylation. Neurochem Int. 2001;39(5):341-348.
-
(2001)
Neurochem Int
, vol.39
, Issue.5
, pp. 341-348
-
-
Sheng, J.G.1
Jones, R.A.2
Zhou, X.Q.3
-
142
-
-
33645809729
-
Interleukin-1 mediates Alzheimer and Lewy body pathologies
-
Griffin WST, Liu L, Li Y, Mrak RE, Barger SW. Interleukin-1 mediates Alzheimer and Lewy body pathologies. J Neuroinflammation. 2006;3(1):5.
-
(2006)
J Neuroinflammation
, vol.3
, Issue.1
, pp. 5
-
-
Griffin, W.S.T.1
Liu, L.2
Li, Y.3
Mrak, R.E.4
Barger, S.W.5
-
143
-
-
84874882726
-
Sustained interleukin-1 beta overexpression exacerbates tau pathology despite reduced Amyloid burden in an Alzheimer’s mouse model
-
Ghosh S, Wu MD, Shaftel SS, et al. Sustained interleukin-1 beta overexpression exacerbates tau pathology despite reduced Amyloid burden in an Alzheimer’s mouse model. J Neurosci. 2013;33(11):5053-5064.
-
(2013)
J Neurosci
, vol.33
, Issue.11
, pp. 5053-5064
-
-
Ghosh, S.1
Wu, M.D.2
Shaftel, S.S.3
-
144
-
-
36849052929
-
Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1 beta injections into the dorsal hippocampus
-
Hein AM, Stutzman DL, Bland ST, et al. Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1 beta injections into the dorsal hippocampus. Neuroscience. 2007;150(4):754-763.
-
(2007)
Neuroscience
, vol.150
, Issue.4
, pp. 754-763
-
-
Hein, A.M.1
Stutzman, D.L.2
Bland, S.T.3
-
145
-
-
72649097241
-
Sustained hippocampal IL-1β overexpression impairs contextual and spatial memory in transgenic mice
-
Hein AM, Stasko MR, Matousek SB, et al. Sustained hippocampal IL-1β overexpression impairs contextual and spatial memory in transgenic mice. Brain Behav Immun. 2010;24(2):243-253.
-
(2010)
Brain Behav Immun
, vol.24
, Issue.2
, pp. 243-253
-
-
Hein, A.M.1
Stasko, M.R.2
Matousek, S.B.3
-
146
-
-
84860751910
-
Chronic IL-1 beta-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer’s disease without inducing overt neurodegeneration
-
Matousek SB, Ghosh S, Shaftel SS, Kyrkanides S, Olschowka JA, O’Banion MK. Chronic IL-1 beta-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer’s disease without inducing overt neurodegeneration. J Neuroimmune Pharmacol. 2012;7(1):156-164.
-
(2012)
J Neuroimmune Pharmacol
, vol.7
, Issue.1
, pp. 156-164
-
-
Matousek, S.B.1
Ghosh, S.2
Shaftel, S.S.3
Kyrkanides, S.4
Olschowka, J.A.5
O’Banion, M.K.6
-
147
-
-
84869857934
-
Interleukin-6, a major cytokine in the central nervous system
-
Erta M, Quintana A, Hidalgo J. Interleukin-6, a major cytokine in the central nervous system. Int J Biol Sci. 2012;8(9):1254-1266.
-
(2012)
Int J Biol Sci
, vol.8
, Issue.9
, pp. 1254-1266
-
-
Erta, M.1
Quintana, A.2
Hidalgo, J.3
-
148
-
-
34548555711
-
Genetics of Alzheimer’s disease. A rapidly evolving field
-
Serretti A, Olgiati P, De Ronchi D. Genetics of Alzheimer’s disease. A rapidly evolving field. J Alzheimer Dis. 2007;12(1):73-92.
-
(2007)
J Alzheimer Dis
, vol.12
, Issue.1
, pp. 73-92
-
-
Serretti, A.1
Olgiati, P.2
De Ronchi, D.3
-
149
-
-
84939214550
-
Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer’s disease
-
Chen SY, Chen TF, Lai LC, et al. Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer’s disease. J Neuroinflammation. 2012;24:9.
-
(2012)
J Neuroinflammation
, vol.24
, pp. 9
-
-
Chen, S.Y.1
Chen, T.F.2
Lai, L.C.3
-
150
-
-
84862005841
-
IL-6-174 G/C and-572 C/G polymorphisms and risk of Alzheimer’s disease
-
Qi H-P, Qu Z-Y, Duan S-R, Wei S-Q, Wen S-R, Bi S. IL-6-174 G/C and-572 C/G polymorphisms and risk of Alzheimer’s disease. PLoS One. 2012;7(6):e37858.
-
(2012)
PLoS One
, vol.7
, Issue.6
-
-
Qi, H.-P.1
Qu, Z.-Y.2
Duan, S.-R.3
Wei, S.-Q.4
Wen, S.-R.5
Bi, S.6
-
152
-
-
1642420308
-
Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway
-
Quintanilla RA, Orellana DI, González-Billault C, Maccioni RB. Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway. Exp Cell Res. 2004;295(1):245-257.
-
(2004)
Exp Cell Res
, vol.295
, Issue.1
, pp. 245-257
-
-
Quintanilla, R.A.1
Orellana, D.I.2
González-Billault, C.3
McCioni, R.B.4
-
153
-
-
84882436628
-
Association between interleukin-6-174G/C polymorphism and the risk of Alzheimer’s disease: A meta-analysis
-
Hua Y, Guo X, Huang Q, Kong Y, Lu X. Association between interleukin-6-174G/C polymorphism and the risk of Alzheimer’s disease: a meta-analysis. Int J Neurosci. 2013;123(9):626-635.
-
(2013)
Int J Neurosci
, vol.123
, Issue.9
, pp. 626-635
-
-
Hua, Y.1
Guo, X.2
Huang, Q.3
Kong, Y.4
Lu, X.5
-
154
-
-
0035255055
-
IL-4, IL-10 and IL-13 modulate Aβ (1-42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line
-
Szczepanik AM, Funes S, Petko W, Ringheim GE. IL-4, IL-10 and IL-13 modulate Aβ (1-42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line. J Neuroimmunol. 2001;113(1):49-62.
-
(2001)
J Neuroimmunol
, vol.113
, Issue.1
, pp. 49-62
-
-
Szczepanik, A.M.1
Funes, S.2
Petko, W.3
Ringheim, G.E.4
-
155
-
-
44949173099
-
Blocking TGF-β-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology
-
Town T, Laouar Y, Pittenger C, et al. Blocking TGF-β-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat Med. 2008;14(6):681-687.
-
(2008)
Nat Med
, vol.14
, Issue.6
, pp. 681-687
-
-
Town, T.1
Laouar, Y.2
Pittenger, C.3
-
156
-
-
33846435323
-
Abeta40 inhibits amyloid deposition in vivo
-
Kim J, Onstead L, Randle S, et al. Abeta40 inhibits amyloid deposition in vivo. J Neurosci. 2007;27(3):627-633.
-
(2007)
J Neurosci
, vol.27
, Issue.3
, pp. 627-633
-
-
Kim, J.1
Onstead, L.2
Randle, S.3
-
157
-
-
84878893173
-
Inflammatory proteins in plasma are associated with severity of Alzheimer’s disease
-
Leung R, Proitsi P, Simmons A, et al. Inflammatory proteins in plasma are associated with severity of Alzheimer’s disease. PLoS One. 2013;8(6):e64971.
-
(2013)
PLoS One
, vol.8
, Issue.6
-
-
Leung, R.1
Proitsi, P.2
Simmons, A.3
-
158
-
-
84864357300
-
The neuroprotective functions of transforming growth factor beta proteins
-
Dobolyi A, Vincze C, Pal G, Lovas G. The neuroprotective functions of transforming growth factor beta proteins. Int J Mol Sci. 2012;13(7):8219-8258.
-
(2012)
Int J Mol Sci
, vol.13
, Issue.7
, pp. 8219-8258
-
-
Dobolyi, A.1
Vincze, C.2
Pal, G.3
Lovas, G.4
-
159
-
-
33745252827
-
Increased intrathecal TGF-β1, but not IL-12, IFN-γ and IL-10 levels in Alzheimer’s disease patients
-
Rota E, Bellone G, Rocca P, Bergamasco B, Emanuelli G, Ferrero P. Increased intrathecal TGF-β1, but not IL-12, IFN-γ and IL-10 levels in Alzheimer’s disease patients. Neurol Sci. 2006;27(1):33-39.
-
(2006)
Neurol Sci
, vol.27
, Issue.1
, pp. 33-39
-
-
Rota, E.1
Bellone, G.2
Rocca, P.3
Bergamasco, B.4
Emanuelli, G.5
Ferrero, P.6
-
160
-
-
35448979876
-
Altered plasma cytokine levels in Alzheimer’s disease: Correlation with the disease progression
-
Motta M, Imbesi R, Di Rosa M, Stivala F, Malaguarnera L. Altered plasma cytokine levels in Alzheimer’s disease: correlation with the disease progression. Immunol Lett. 2007;114(1):46-51.
-
(2007)
Immunol Lett
, vol.114
, Issue.1
, pp. 46-51
-
-
Motta, M.1
Imbesi, R.2
Di Rosa, M.3
Stivala, F.4
Malaguarnera, L.5
-
161
-
-
79959669857
-
Expression profiles of cytokines in the brains of Alzheimer’s disease (AD) patients compared to the brains of non-demented patients with and without increasing AD pathology
-
Morimoto K, Horio J, Satoh H, et al. Expression profiles of cytokines in the brains of Alzheimer’s disease (AD) patients compared to the brains of non-demented patients with and without increasing AD pathology. J Alzheimer Dis. 2011;25(1):59-76.
-
(2011)
J Alzheimer Dis
, vol.25
, Issue.1
, pp. 59-76
-
-
Morimoto, K.1
Horio, J.2
Satoh, H.3
-
162
-
-
82755194885
-
Immunotherapy of cerebrovascular amyloidosis in a transgenic mouse model
-
Lifshitz V, Weiss R, Benromano T, et al. Immunotherapy of cerebrovascular amyloidosis in a transgenic mouse model. Neurobiol Aging. 2012;33(2):e431-e432.
-
(2012)
Neurobiol Aging
, vol.33
, Issue.2
, pp. e431-e432
-
-
Lifshitz, V.1
Weiss, R.2
Benromano, T.3
-
163
-
-
84881372319
-
Decreased serum levels of the angiogenic factors VEGF and TGF-beta1 in Alzheimer’s disease and amnestic mild cognitive impairment
-
Huang L, Jia J, Liu R. Decreased serum levels of the angiogenic factors VEGF and TGF-beta1 in Alzheimer’s disease and amnestic mild cognitive impairment. Neurosci Lett. 2013;550:60-63.
-
(2013)
Neurosci Lett
, vol.550
, pp. 60-63
-
-
Huang, L.1
Jia, J.2
Liu, R.3
-
164
-
-
6944250594
-
Increased plasma levels of soluble CD40, together with the decrease of TGFβ1, as possible differential markers of Alzheimer disease
-
Mocali A, Cedrola S, Della Malva N, et al. Increased plasma levels of soluble CD40, together with the decrease of TGFβ1, as possible differential markers of Alzheimer disease. Exp Gerontol. 2004;39(10):1555-1561.
-
(2004)
Exp Gerontol
, vol.39
, Issue.10
, pp. 1555-1561
-
-
Mocali, A.1
Cedrola, S.2
Della Malva, N.3
-
165
-
-
56349166514
-
Mechanisms of microglia accumulation in Alzheimer’s disease: Therapeutic implications
-
Khoury JE, Luster AD. Mechanisms of microglia accumulation in Alzheimer’s disease: therapeutic implications. Trends Pharmacol Sci. 2008;29(12):626-632.
-
(2008)
Trends Pharmacol Sci
, vol.29
, Issue.12
, pp. 626-632
-
-
Khoury, J.E.1
Luster, A.D.2
-
166
-
-
84859444926
-
Dysfunction of TGF-β1 signaling in Alzheimer’s disease: Perspectives for neuroprotection
-
Caraci F, Spampinato S, Sortino MA, et al. Dysfunction of TGF-β1 signaling in Alzheimer’s disease: perspectives for neuroprotection. Cell Tissue Res. 2012;347(1):291-301.
-
(2012)
Cell Tissue Res
, vol.347
, Issue.1
, pp. 291-301
-
-
Caraci, F.1
Spampinato, S.2
Sortino, M.A.3
-
167
-
-
84867694565
-
TGF-beta induced by interleukin-34-stimulated microglia regulates microglial proliferation and attenuates oligomeric amyloid beta neurotoxicity
-
Ma D, Doi Y, Jin S, et al. TGF-beta induced by interleukin-34-stimulated microglia regulates microglial proliferation and attenuates oligomeric amyloid beta neurotoxicity. Neurosci Lett. 2012;529(1):86-91.
-
(2012)
Neurosci Lett
, vol.529
, Issue.1
, pp. 86-91
-
-
Ma, D.1
Doi, Y.2
Jin, S.3
-
168
-
-
84864857755
-
Transforming growth factor-beta stimulates beta amyloid uptake by microglia through Smad3-dependent mechanisms
-
Tichauer JE, von Bernhardi R. Transforming growth factor-beta stimulates beta amyloid uptake by microglia through Smad3-dependent mechanisms. J Neurosci Res. 2012;90(10):1970-1980.
-
(2012)
J Neurosci Res
, vol.90
, Issue.10
, pp. 1970-1980
-
-
Tichauer, J.E.1
von Bernhardi, R.2
-
169
-
-
79957926734
-
TGF-β1 affects endothelial cell interaction with macrophages and T-cells leading to the development of cerebrovascular amyloidosis
-
Weiss R, Lifshitz V, Frenkel D. TGF-β1 affects endothelial cell interaction with macrophages and T-cells leading to the development of cerebrovascular amyloidosis. Brain Behav Immun. 2011;25(5):1017-1024.
-
(2011)
Brain Behav Immun
, vol.25
, Issue.5
, pp. 1017-1024
-
-
Weiss, R.1
Lifshitz, V.2
Frenkel, D.3
-
170
-
-
84888134284
-
Chronic over-expression of TGF beta 1 alters hippocampal structure and causes learning deficits
-
Martinez-Canabal A, Wheeler AL, Sarkis D, et al. Chronic over-expression of TGF beta 1 alters hippocampal structure and causes learning deficits. Hippocampus. 2013;23(12):1198-1211.
-
(2013)
Hippocampus
, vol.23
, Issue.12
, pp. 1198-1211
-
-
Martinez-Canabal, A.1
Wheeler, A.L.2
Sarkis, D.3
-
171
-
-
77951776829
-
Alzheimer’s disease: Strategies for disease modification
-
Citron M. Alzheimer’s disease: strategies for disease modification. Nat Rev Drug Discov. 2010;9(5):387-398.
-
(2010)
Nat Rev Drug Discov
, vol.9
, Issue.5
, pp. 387-398
-
-
Citron, M.1
-
172
-
-
76849086405
-
The secretases: Enzymes with therapeutic potential in Alzheimer disease
-
De Strooper B, Vassar R, Golde T. The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat Rev Neurol. 2010;6(2):99-107.
-
(2010)
Nat Rev Neurol
, vol.6
, Issue.2
, pp. 99-107
-
-
De Strooper, B.1
Vassar, R.2
Golde, T.3
-
174
-
-
77954132249
-
Amyloid-[beta]-induced neuronal dysfunction in Alzheimer’s disease: From synapses toward neural networks
-
Palop JJ, Mucke L. Amyloid-[beta]-induced neuronal dysfunction in Alzheimer’s disease: from synapses toward neural networks. Nat Neurosci. 2010;13(7):812-818.
-
(2010)
Nat Neurosci
, vol.13
, Issue.7
, pp. 812-818
-
-
Palop, J.J.1
Mucke, L.2
-
175
-
-
78650647193
-
Astrocytes in Alzheimer’s disease: Emerging roles in calcium dysregulation and synaptic plasticity
-
Vincent AJ, Gasperini R, Foa L, Small DH. Astrocytes in Alzheimer’s disease: emerging roles in calcium dysregulation and synaptic plasticity. J Alzheimers Dis. 2010;22(3):699-714.
-
(2010)
J Alzheimers Dis
, vol.22
, Issue.3
, pp. 699-714
-
-
Vincent, A.J.1
Gasperini, R.2
Foa, L.3
Small, D.H.4
-
176
-
-
84896857538
-
Amyloid beta: Multiple mechanisms of toxicity and only some protective effects?
-
Carrillo-Mora P, Luna R, Colin-Barenque L. Amyloid beta: multiple mechanisms of toxicity and only some protective effects? Oxid Med Cell Longev. 2014;2014:795375.
-
(2014)
Oxid Med Cell Longev
, vol.2014
-
-
Carrillo-Mora, P.1
Luna, R.2
Colin-Barenque, L.3
-
177
-
-
84883315336
-
Inflammatory components in human Alzheimer’s disease and after active amyloid-beta(42) immunization
-
Zotova E, Bharambe V, Cheaveau M, et al. Inflammatory components in human Alzheimer’s disease and after active amyloid-beta(42) immunization. Brain. 2013;136:2677-2696.
-
(2013)
Brain
, vol.136
, pp. 2677-2696
-
-
Zotova, E.1
Bharambe, V.2
Cheaveau, M.3
-
178
-
-
84881548115
-
Amyloid beta immunization worsens iron deposits in the choroid plexus and cerebral microbleeds
-
Joseph-Mathurin N, Dorieux O, Trouche SG, et al. Amyloid beta immunization worsens iron deposits in the choroid plexus and cerebral microbleeds. Neurobiol Aging. 2013;34(11):2613-2622.
-
(2013)
Neurobiol Aging
, vol.34
, Issue.11
, pp. 2613-2622
-
-
Joseph-Mathurin, N.1
Dorieux, O.2
Trouche, S.G.3
-
179
-
-
84894033757
-
Is there still any hope for amyloid-based immunotherapy for Alzheimer’s disease?
-
Panza F, Logroscino G, Imbimbo BP, Solfrizzi V. Is there still any hope for amyloid-based immunotherapy for Alzheimer’s disease? Curr Opin Psychiatry. 2014;27(2):128-137.
-
(2014)
Curr Opin Psychiatry
, vol.27
, Issue.2
, pp. 128-137
-
-
Panza, F.1
Logroscino, G.2
Imbimbo, B.P.3
Solfrizzi, V.4
-
180
-
-
79953087890
-
The acetylation of tau inhibits its function and promotes pathological tau aggregation
-
Cohen TJ, Guo JL, Hurtado DE, et al. The acetylation of tau inhibits its function and promotes pathological tau aggregation. Nat Commun. 2011;2:252.
-
(2011)
Nat Commun
, vol.2
, pp. 252
-
-
Cohen, T.J.1
Guo, J.L.2
Hurtado, D.E.3
-
181
-
-
84862833600
-
Tau in Alzheimer disease and related tauopathies
-
Iqbal K, Liu F, Gong C-X, Grundke-Iqbal I. Tau in Alzheimer disease and related tauopathies. Curr Alzheimer Res. 2010;7(8):656.
-
(2010)
Curr Alzheimer Res
, vol.7
, Issue.8
, pp. 656
-
-
Iqbal, K.1
Liu, F.2
Gong, C.-X.3
Grundke-Iqbal, I.4
-
182
-
-
77957001697
-
Acetylation of tau inhibits its degradation and contributes to tauopathy
-
Min SW, Cho SH, Zhou Y, et al. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 2010;67(6):953-966.
-
(2010)
Neuron
, vol.67
, Issue.6
, pp. 953-966
-
-
Min, S.W.1
Cho, S.H.2
Zhou, Y.3
-
183
-
-
79955670132
-
The many faces of tau
-
Morris M, Maeda S, Vossel K, Mucke L. The many faces of tau. Neuron. 2011;70(3):410-426.
-
(2011)
Neuron
, vol.70
, Issue.3
, pp. 410-426
-
-
Morris, M.1
Maeda, S.2
Vossel, K.3
Mucke, L.4
-
184
-
-
84886509822
-
A role for tau at the synapse in Alzheimer’s disease pathogenesis
-
Pooler AM, Noble W, Hanger DP. A role for tau at the synapse in Alzheimer’s disease pathogenesis. Neuropharmacology. 2014;76:1-8.
-
(2014)
Neuropharmacology
, vol.76
, pp. 1-8
-
-
Pooler, A.M.1
Noble, W.2
Hanger, D.P.3
-
185
-
-
33845954777
-
It may take inflammation, phosphorylation and ubiquitination to “tangle” in Alzheimer’s disease
-
Arnaud L, Robakis NK, Figueiredo-Pereira ME. It may take inflammation, phosphorylation and ubiquitination to “tangle” in Alzheimer’s disease. Neurodegener Dis. 2006;3(6):313-319.
-
(2006)
Neurodegener Dis
, vol.3
, Issue.6
, pp. 313-319
-
-
Arnaud, L.1
Robakis, N.K.2
Figueiredo-Pereira, M.E.3
-
187
-
-
84882793431
-
Repeated immunization of mice with phosphorylated-tau peptides causes neuroinflammation
-
Rozenstein-Tsalkovich L, Grigoriadis N, Lourbopoulos A, et al. Repeated immunization of mice with phosphorylated-tau peptides causes neuroinflammation. Exp Neurol. 2013;248:451-456.
-
(2013)
Exp Neurol
, vol.248
, pp. 451-456
-
-
Rozenstein-Tsalkovich, L.1
Grigoriadis, N.2
Lourbopoulos, A.3
-
188
-
-
84886600387
-
Therapeutics of Alzheimer’s disease: Past, present and future
-
Anand R, Gill KD, Mahdi AA. Therapeutics of Alzheimer’s disease: past, present and future. Neuropharmacology. 2014;76:27-50.
-
(2014)
Neuropharmacology
, vol.76
, pp. 27-50
-
-
Anand, R.1
Gill, K.D.2
Mahdi, A.A.3
|