Microglia, scavenger receptors, and the pathogenesis of Alzheimer's disease

Neurobiology of Aging

Volumn 19, Issue SUPPL. 1, 1998, Pages

  El Khoury, J ^a   Hickman, S E ^a   Thomas, C A ^a   Loike, J D ^a   Silverstein, S C ^a  

^a Columbia Univ Coll Phys Surgs ^*  (United States)

Author keywords

Amyloid; Endothelial cells; Microglia; Migration; Reactive oxygen species; Scavenger receptors

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; REACTIVE OXYGEN METABOLITE; SCAVENGER RECEPTOR; SCLEROPROTEIN;

ALZHEIMER DISEASE; ASTROCYTE; CONFERENCE PAPER; ENDOTHELIUM CELL; HUMAN; MICROGLIA; NERVE CELL DEGENERATION; NEUROTOXICITY; PATHOGENESIS; PRIORITY JOURNAL; SENILE PLAQUE;

ALZHEIMER DISEASE; ANIMALS; FREE RADICAL SCAVENGERS; HUMANS; MICROGLIA; REACTIVE OXYGEN SPECIES;

EID: 0031957224     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(98)00036-0     Document Type: Conference Paper

References (31)

1. Betz-Corradin S., Mauel J., Denis-Donini S., Quattrochi E., Ricciardi-Castagnoli P. Inducible nitric oxide synthase activity of cloned murine microglial cells. Glia. 7:1993;255-262.
2. Bickel P. E., Freeman M. W. Rabbit smooth muscle cells express inducible macrophage scavenger receptor mRNA that is absent from endothelial cells. J. Clin. Invest. 90:1992;1450-1457.
3. Boje K. M., Arora K. P. Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res. 587:1992;250-256.
4. Boyles J. K., Pitas R. E., Wilson E., Mahley R. W., Taylor J. M. ApoE associated with astrocytic glia of the CNS and with non-myelinating glia of the PNS. J. Clin. Invest. 76:1985;1501-1513.
5. Christie R. H., Freeman M., Hyman B. T. Expression of macrophage scavenger receptor a multifunctional lipoprotein receptor in microglia associated with senile plaques in Alzheimer's disease. Am. J. Path. 148:1996;399-403.
6. Duan H., Li Z., Mazzone T. TNF modulates monocyte/macrophage ApoE gene expression. J. Clin. Invest. 96:1995;915-922.
7. El Khoury J., Hickman S. E., Thomas C. A., Cao L., Silverstein S. C., Loike J. D. Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils. Nature. 382:1996;716-719.
8. El Khoury J., Thomas C. A., Loike J. D., Hickman S. E., Cao L., Silverstein S. C. Macrophages adhere to Glucose-modified basement collagen IV via their scavenger receptors. J. Biol. Chem. 269:1994;10197-10200.
9. Giulian D., Baker T. J. Characterization of ameboid microglia isolated from developing mammalian brain. J. Neurosci. 6:1986;2163-2178.
10. Hickman S. E., El Khoury J., Greenberg S., Schieren I., Silverstein S. C. P2Z ATP receptor activity in cultured human monocyte-derived macrophages. Blood. 84:1994;2452-2456.
11. Ishii T., Haga S. Immuno-electron microscopic localization of complement in amyloid fibrils of senile plaques. Acta Neuropath. 63:1984;296-305.
12. Jiang H., Burdick D., Glabe C. G., Cotman C. W., Tanner A. J. Beta amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. J. Immun. 152:1994;5050-5059.
13. Klegeris A., Walker D. G., McGeer P. L. Activation of macrophages by Alzheimer beta amyloid peptide. Biochem. Biophys. Res. Comm. 199:1994;984-991.
14. Krieger M., Herz J. Structures and functions of multiligand lipoprotein receptors Macrophage scavenger receptors and LDL receptor-related protein . Ann. Rev. Biochem. 63:1994;601-637.
15. Loike J. D., El Khoury J., Cao L., Richards C. P., Rascoff H., Manderville T. H., Maxfield F. R., Silverstein S. C. Fibrin regulates neutrophil migration in response to Interleukin 8, Leukotriene B4, TNF, and FMLP. J. Exp. Med. 181:1995;1763-1772.
16. Lorenzo A., Yankner B. A. Beta amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc. Natl. Acad. Sci. USA. 91:1994;12243-12247.
17. Mazzone T., Basheeruddin K., Poulos C. Regulation of macrophage ApoE gene expression by cholesterol. J. Lipid Res. 30:1989;1055-1064.
18. McGeer P. L., Walker D. G., Haruhiko A., Yasuhara O., McGeer E. G. Involvement of microglia in Alzheimer's disease. Neuropath. Appl. Neurosci. 20:1994;191-192.
19. Meda L., Cassatella M. A., Szendrei G. I., Otvos L. Jr, Baron P., Villalba M., Ferrari D., Rossi F. Activation of microglial cells by beta amyloid protein and interferon gamma. Nature. 374:1995;647-650.
20. Muller-Eberhard H. J. Molecular organization and function of the complement system Ann. Rev. Biochem. 57:1988;321-347.
21. Paresce D. M., Ghosh R. N., Maxfield F. R. Microglial cells internalize aggregates of Alzheimer's disease amyloid beta protein via a scavenger receptor. Neuron. 17:1996;553-565.
22. Perlmutter L. S., Chang Chui H. Microangiopathy, the vascular basement membrane and Alzheimer's disease: A review. Brain Res. Bull. 24:1990;677-686.
23. Sawamura T., Kume N., Aoyama T., Moriwaki H., Hoshikawa H., Aiba Y., Tanaka T., Miwa S., Yoshimoto K., Kita T., Masaki T. An endothelial receptor for oxidized LDL. Nature. 386:1997;73-77.
24. Schmidt A. M., Hori O., Chen J. X., Li J. F., Crandall J., Zhang J., Cao R., Yan S. D., Brett J., Stern D. AGEs interacting with their endothelial receptor induce expression of VCAM-1 in cultured human endothelial cells and mice. J. Clin. Invest. 96:1995;1395-1403.
25. Sisodia S. S., Price D. L. Role of the β-amyloid protein in Alzheimer's disease. FASEB J. 9:1995;366-370.
26. 125I-labeled low density lipoprotein. Biochim. Biophys. Acta. 620:1980;631-635.
27. Strittmatter W. J., Roses A. D. Apolipoprotein E and Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 92:1995;4725-4727.
28. Thomas T., Thomas G., Mclendon C., Sutton T., Mullan M. β-amyloid-mediated vasoactivity and vascular endothelial damage. Nature. 380:1996;168-171.
29. Werb Z., Chin J. R. ApoE is synthesized and secreted by resident and thioglycollate ellicited macrophages but not by pyran copolymer- or BCG activated macrophages. J. Exp. Med. 158:1983;1272-1293.
30. Werb Z., Takemura R., Stenberg P. E., Bainton D. F. Directed exocytosis of secretory granules containing apoE to the adherent surface and basal vacuoles of macrophages spreading on immobile immune complexes. Am. J. Path. 134:1989;661-670.
31. Wisiniewski H. M., Robe A., Zigman W., Silverman W. Neuropathological diagnosis of Alzheimer's disease. J. Neuropath. Exp. Neurol. 48:1989;606-609.