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Volumn 38, Issue 4, 2014, Pages 787-798

Functional and molecular characterization of the effect of amyloid-β42 on an in vitro epithelial barrier model

Author keywords

Alzheimer's disease; Amyloid ; Blood brain barrier; Claudin 2; Endothelial cells; Occluding; Permeability

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; CLAUDIN 2; OCCLUDIN;

EID: 84890490409     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-122374     Document Type: Article
Times cited : (21)

References (67)
  • 1
    • 67349142021 scopus 로고    scopus 로고
    • Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease
    • Bell RD, Zlokovic BV (2009) Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol 118, 103-113.
    • (2009) Acta Neuropathol , vol.118 , pp. 103-113
    • Bell, R.D.1    Zlokovic, B.V.2
  • 2
    • 84862885703 scopus 로고    scopus 로고
    • Abeta(1)(-)(4)(2)-RAGE interaction disrupts tight junctions of the blood-brain barrier via Ca(2)(+)-calcineurin signaling
    • Kook SY, Hong HS, Moon M, Ha CM, Chang S, Mook-Jung I (2012) Abeta(1)(-)(4)(2)-RAGE interaction disrupts tight junctions of the blood-brain barrier via Ca(2)(+)-calcineurin signaling. J Neurosci 32, 8845-8854.
    • (2012) J Neurosci , vol.32 , pp. 8845-8854
    • Kook, S.Y.1    Hong, H.S.2    Moon, M.3    Ha, C.M.4    Chang, S.5    Mook-Jung, I.6
  • 3
    • 33747436236 scopus 로고    scopus 로고
    • Amyloid beta-peptide1-42 alters tight junction protein distribution and expression in brain microvessel endothelial cells
    • Marco S, Skaper SD (2006) Amyloid beta-peptide1-42 alters tight junction protein distribution and expression in brain microvessel endothelial cells. Neurosci Lett 401, 219-224.
    • (2006) Neurosci Lett , vol.401 , pp. 219-224
    • Marco, S.1    Skaper, S.D.2
  • 5
    • 84862834603 scopus 로고    scopus 로고
    • Tight junctions on the move:Molecular mechanisms for epithelial barrier regulation
    • Shen L (2012) Tight junctions on the move:Molecular mechanisms for epithelial barrier regulation. Ann N Y Acad Sci 1258, 9-18.
    • (2012) Ann N y Acad Sci , vol.1258 , pp. 9-18
    • Shen, L.1
  • 6
    • 77954711307 scopus 로고    scopus 로고
    • Amyloid-beta-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation
    • Tai LM, Holloway KA, Male DK, Loughlin AJ, Romero IA (2010) Amyloid-beta-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation. J Cell Mol Med 14, 1101-1112.
    • (2010) J Cell Mol Med , vol.14 , pp. 1101-1112
    • Tai, L.M.1    Holloway, K.A.2    Male, D.K.3    Loughlin, A.J.4    Romero, I.A.5
  • 8
    • 0034870813 scopus 로고    scopus 로고
    • Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease
    • Poduslo JF, Curran GL, Wengenack TM, Malester B, Duff K (2001) Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease. Neurobiol Dis 8, 555-567.
    • (2001) Neurobiol Dis , vol.8 , pp. 555-567
    • Poduslo, J.F.1    Curran, G.L.2    Wengenack, T.M.3    Malester, B.4    Duff, K.5
  • 9
    • 34250623663 scopus 로고    scopus 로고
    • Blood-brain barrier pathology in Alzheimer's and Parkinson's disease: Implications for drug therapy
    • Desai BS, Monahan AJ, Carvey PM, Hendey B (2007) Blood-brain barrier pathology in Alzheimer's and Parkinson's disease: Implications for drug therapy. Cell Transplant 16, 285-299.
    • (2007) Cell Transplant , vol.16 , pp. 285-299
    • Desai, B.S.1    Monahan, A.J.2    Carvey, P.M.3    Hendey, B.4
  • 10
    • 84861443482 scopus 로고    scopus 로고
    • Alzheimer's disease: A breach in the blood-brain barrier
    • Carmeliet P, De Strooper B (2012) Alzheimer's disease: A breach in the blood-brain barrier. Nature 485, 451-452.
    • (2012) Nature , vol.485 , pp. 451-452
    • Carmeliet, P.1    De Strooper, B.2
  • 11
    • 84858146983 scopus 로고    scopus 로고
    • Modulation of tight junction structure and function by kinases and phosphatases targeting occludin
    • Dorfel MJ, Huber O (2012) Modulation of tight junction structure and function by kinases and phosphatases targeting occludin. J Biomed Biotechnol 2012, 807356.
    • (2012) J Biomed Biotechnol , vol.2012 , pp. 807356
    • Dorfel, M.J.1    Huber, O.2
  • 14
    • 82455162480 scopus 로고    scopus 로고
    • Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: A study in the MRC-CFASpopulation neuropathology cohort
    • Viggars AP, Wharton SB, Simpson JE, Matthews FE, Brayne C, Savva GM, Garwood C, Drew D, Shaw PJ, Ince PG (2011) Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: A study in the MRC-CFASpopulation neuropathology cohort. Neurosci Lett 505, 25-30.
    • (2011) Neurosci Lett , vol.505 , pp. 25-30
    • Viggars, A.P.1    Wharton, S.B.2    Simpson, J.E.3    Matthews, F.E.4    Brayne, C.5    Savva, G.M.6    Garwood, C.7    Drew, D.8    Shaw, P.J.9    Ince, P.G.10
  • 15
    • 53149133922 scopus 로고    scopus 로고
    • Soluble aggregates of the amyloid-beta protein selectively stimulate permeability in human brain microvascular endothelial monolayers
    • Gonzalez-Velasquez FJ, Kotarek JA, Moss MA (2008) Soluble aggregates of the amyloid-beta protein selectively stimulate permeability in human brain microvascular endothelial monolayers. J Neurochem 107, 466-477.
    • (2008) J Neurochem , vol.107 , pp. 466-477
    • Gonzalez-Velasquez, F.J.1    Kotarek, J.A.2    Moss, M.A.3
  • 18
    • 47249165979 scopus 로고    scopus 로고
    • Amyloid beta toxicity dependent upon endothelial cell state
    • Balcells M, Wallins JS, Edelman ER (2008) Amyloid beta toxicity dependent upon endothelial cell state. Neurosci Lett 441, 319-322.
    • (2008) Neurosci Lett , vol.441 , pp. 319-322
    • Balcells, M.1    Wallins, J.S.2    Edelman, E.R.3
  • 22
    • 80053554604 scopus 로고    scopus 로고
    • The MDCK variety pack: Choosing the right strain
    • Dukes JD, Whitley P, Chalmers AD (2011) The MDCK variety pack: Choosing the right strain. BMC Cell Biol 12, 43.
    • (2011) BMC Cell Biol , vol.12 , pp. 43
    • Dukes, J.D.1    Whitley, P.2    Chalmers, A.D.3
  • 23
    • 0030453193 scopus 로고    scopus 로고
    • Identification of a cytoplasmic domain important in the polarized expression and clustering of the Kv2.1 K+ channel
    • Scannevin RH, Murakoshi H, Rhodes KJ, Trimmer JS (1996) Identification of a cytoplasmic domain important in the polarized expression and clustering of the Kv2.1 K+ channel. J Cell Biol 135, 1619-1632.
    • (1996) J Cell Biol , vol.135 , pp. 1619-1632
    • Scannevin, R.H.1    Murakoshi, H.2    Rhodes, K.J.3    Trimmer, J.S.4
  • 24
    • 0028985176 scopus 로고
    • Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals
    • Haass C, Koo EH, Capell A, Teplow DB, Selkoe DJ (1995) Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals. J Cell Biol 128, 537-547.
    • (1995) J Cell Biol , vol.128 , pp. 537-547
    • Haass, C.1    Koo, E.H.2    Capell, A.3    Teplow, D.B.4    Selkoe, D.J.5
  • 25
    • 40849102300 scopus 로고    scopus 로고
    • LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model
    • Nazer B, Hong S, Selkoe DJ (2008) LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model. Neurobiol Dis 30, 94-102.
    • (2008) Neurobiol Dis , vol.30 , pp. 94-102
    • Nazer, B.1    Hong, S.2    Selkoe, D.J.3
  • 26
    • 0028181256 scopus 로고
    • Polarized secretion of beta-amyloid precursor protein and amyloid betapeptide in MDCK cells
    • Haass C, Koo EH, Teplow DB, Selkoe DJ (1994) Polarized secretion of beta-amyloid precursor protein and amyloid betapeptide in MDCK cells. Proc Natl Acad Sci U S A 91, 1564-1568.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 1564-1568
    • Haass, C.1    Koo, E.H.2    Teplow, D.B.3    Selkoe, D.J.4
  • 27
    • 0037085453 scopus 로고    scopus 로고
    • Apical sorting of beta-secretase limits amyloid betapeptide production
    • Capell A, Meyn L, Fluhrer R, Teplow DB, Walter J, Haass C (2002) Apical sorting of beta-secretase limits amyloid betapeptide production. J Biol Chem 277, 5637-5643.
    • (2002) J Biol Chem , vol.277 , pp. 5637-5643
    • Capell, A.1    Meyn, L.2    Fluhrer, R.3    Teplow, D.B.4    Walter, J.5    Haass, C.6
  • 31
    • 63249115678 scopus 로고    scopus 로고
    • The blood-brain barrier in brain homeostasis and neurological diseases
    • Weiss N, Miller F, Cazaubon S, Couraud PO (2009) The blood-brain barrier in brain homeostasis and neurological diseases. Biochim Biophys Acta 1788, 842-857.
    • (2009) Biochim Biophys Acta , vol.1788 , pp. 842-857
    • Weiss, N.1    Miller, F.2    Cazaubon, S.3    Couraud, P.O.4
  • 32
    • 0141749108 scopus 로고    scopus 로고
    • Distinct effects of protein kinase C on the barrier function at different developmental stages
    • Sjo A, Magnusson KE, Peterson KH (2003) Distinct effects of protein kinase C on the barrier function at different developmental stages. Biosci Rep 23, 87-102.
    • (2003) Biosci Rep , vol.23 , pp. 87-102
    • Sjo, A.1    Magnusson, K.E.2    Peterson, K.H.3
  • 33
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyteendothelial interactions at the blood-brain barrier
    • Abbott NJ, Ronnback L, Hansson E (2006) Astrocyteendothelial interactions at the blood-brain barrier. Nat Rev Neurosci 7, 41-53.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 34
    • 84875261981 scopus 로고    scopus 로고
    • New spin on an old transition: Epithelial parallels in neuronal adhesion control
    • Famulski JK, Solecki DJ (2013) New spin on an old transition: Epithelial parallels in neuronal adhesion control. Trends Neurosci 36, 163-173.
    • (2013) Trends Neurosci , vol.36 , pp. 163-173
    • Famulski, J.K.1    Solecki, D.J.2
  • 36
    • 0031759026 scopus 로고    scopus 로고
    • Comparison of the cytotoxic effects of cadmium (Cd(2+)) in high and low resistance strains of MDCK cells that express different levels of ECadherin
    • Prozialeck WC, Lamar PC (1998) Comparison of the cytotoxic effects of cadmium (Cd(2+)) in high and low resistance strains of MDCK cells that express different levels of ECadherin. Toxicol In Vitro 12, 633-647.
    • (1998) Toxicol in Vitro , vol.12 , pp. 633-647
    • Prozialeck, W.C.1    Lamar, P.C.2
  • 37
    • 33747770301 scopus 로고    scopus 로고
    • Side by side comparison between dynamic versus static models of blood-brain barrier in vitro: A permeability study
    • Santaguida S, Janigro D, Hossain M, Oby E, Rapp E, Cucullo L (2006) Side by side comparison between dynamic versus static models of blood-brain barrier in vitro: A permeability study. Brain Res 1109, 1-13.
    • (2006) Brain Res , vol.1109 , pp. 1-13
    • Santaguida, S.1    Janigro, D.2    Hossain, M.3    Oby, E.4    Rapp, E.5    Cucullo, L.6
  • 39
    • 33846014316 scopus 로고    scopus 로고
    • The supramolecular architecture of junctional microdomains in native lens membranes
    • Buzhynskyy N, Hite RK, Walz T, Scheuring S (2007) The supramolecular architecture of junctional microdomains in native lens membranes. EMBO Rep 8, 51-55.
    • (2007) EMBO Rep , vol.8 , pp. 51-55
    • Buzhynskyy, N.1    Hite, R.K.2    Walz, T.3    Scheuring, S.4
  • 41
    • 42349090300 scopus 로고    scopus 로고
    • Cytotoxicity of aggregated fullerene C60 particles on CHO and MDCK cells
    • Han B, Karim MN (2008) Cytotoxicity of aggregated fullerene C60 particles on CHO and MDCK cells. Scanning 30, 213-220.
    • (2008) Scanning , vol.30 , pp. 213-220
    • Han, B.1    Karim, M.N.2
  • 43
    • 4444382459 scopus 로고    scopus 로고
    • Platinum complex toxicity in cultured renal epithelia
    • Ludwig T, Oberleithner H (2004) Platinum complex toxicity in cultured renal epithelia. Cell Physiol Biochem 14, 431-440.
    • (2004) Cell Physiol Biochem , vol.14 , pp. 431-440
    • Ludwig, T.1    Oberleithner, H.2
  • 44
    • 2342609772 scopus 로고    scopus 로고
    • The effect of raft lipid depletion on microvilli formation in MDCK cells, visualized by atomic force microscopy
    • Poole K, Meder D, Simons K, Muller D (2004) The effect of raft lipid depletion on microvilli formation in MDCK cells, visualized by atomic force microscopy. FEBS Lett 565, 53-58.
    • (2004) FEBS Lett , vol.565 , pp. 53-58
    • Poole, K.1    Meder, D.2    Simons, K.3    Muller, D.4
  • 46
    • 0028276694 scopus 로고
    • Surface morphology and mechanical properties of MDCK monolayers by atomic force microscopy
    • Hoh JH, Schoenenberger CA (1994) Surface morphology and mechanical properties of MDCK monolayers by atomic force microscopy. J Cell Sci 107(Pt 5), 1105-1114.
    • (1994) J Cell Sci , vol.107 , Issue.PART 5 , pp. 1105-1114
    • Hoh, J.H.1    Schoenenberger, C.A.2
  • 47
    • 0027769934 scopus 로고
    • Imaging the lamellipodium of migrating epithelial cells in vivo by atomic force microscopy
    • Oberleithner H, Giebisch G, Geibel J (1993) Imaging the lamellipodium of migrating epithelial cells in vivo by atomic force microscopy. Pflugers Arch 425, 506-510.
    • (1993) Pflugers Arch , vol.425 , pp. 506-510
    • Oberleithner, H.1    Giebisch, G.2    Geibel, J.3
  • 49
    • 0025916059 scopus 로고
    • Micromotion of mammalian cells measured electrically
    • Giaever I, Keese CR (1991) Micromotion of mammalian cells measured electrically. Proc Natl Acad Sci U S A 88, 7896-7900.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 7896-7900
    • Giaever, I.1    Keese, C.R.2
  • 50
    • 1542568487 scopus 로고    scopus 로고
    • Disruption of epithelial barrier function by H2O2: Distinct responses of Caco-2 and Madin-Darby canine kidney (MDCK) strains
    • JepsonMA(2003) Disruption of epithelial barrier function by H2O2: Distinct responses of Caco-2 and Madin-Darby canine kidney (MDCK) strains. Cell Mol Biol (Noisy-le-grand) 49, 101-112.
    • (2003) Cell Mol Biol (Noisy-le-grand) , vol.49 , pp. 101-112
    • Jepson, M.A.1
  • 53
    • 33846323280 scopus 로고    scopus 로고
    • Quantification of the heterogeneity in breast cancer cell lines using whole-cell impedance spectroscopy
    • Han A, Yang L, Frazier AB (2007) Quantification of the heterogeneity in breast cancer cell lines using whole-cell impedance spectroscopy. Clin Cancer Res 13, 139-143.
    • (2007) Clin Cancer Res , vol.13 , pp. 139-143
    • Han, A.1    Yang, L.2    Frazier, A.B.3
  • 54
    • 78650461227 scopus 로고    scopus 로고
    • Electrical cell-substrate impedance sensing as a non-invasive tool for cancer cell study
    • Hong J, Kandasamy K, Marimuthu M, Choi CS, Kim S (2011) Electrical cell-substrate impedance sensing as a non-invasive tool for cancer cell study. Analyst 136, 237-245.
    • (2011) Analyst , vol.136 , pp. 237-245
    • Hong, J.1    Kandasamy, K.2    Marimuthu, M.3    Choi, C.S.4    Kim, S.5
  • 55
    • 84855187639 scopus 로고    scopus 로고
    • Simultaneous impedimetric and amperometric interrogation of renal cells exposed to a calculus-forming salt
    • Gaspar S, David S, Polonschii C, Marcu I, Gheorghiu M, Gheorghiu E (2012) Simultaneous impedimetric and amperometric interrogation of renal cells exposed to a calculus-forming salt. Anal Chim Acta 713, 115-120.
    • (2012) Anal Chim Acta , vol.713 , pp. 115-120
    • Gaspar, S.1    David, S.2    Polonschii, C.3    Marcu, I.4    Gheorghiu, M.5    Gheorghiu, E.6
  • 56
    • 84857642949 scopus 로고    scopus 로고
    • The toxic Abeta oligomer and Alzheimer's disease: An emperor in need of clothes
    • Benilova I, Karran E, De Strooper B (2012) The toxic Abeta oligomer and Alzheimer's disease: An emperor in need of clothes. Nat Neurosci 15, 349-357.
    • (2012) Nat Neurosci , vol.15 , pp. 349-357
    • Benilova, I.1    Karran, E.2    De Strooper, B.3
  • 57
    • 84867576631 scopus 로고    scopus 로고
    • Claudin expression profile separates Alzheimer's disease cases from normal aging and from vascular dementia cases
    • Spulber S, Bogdanovic N, Romanitan MO, Bajenaru OA, Popescu BO (2012) Claudin expression profile separates Alzheimer's disease cases from normal aging and from vascular dementia cases. J Neurol Sci 322, 184-186.
    • (2012) J Neurol Sci , vol.322 , pp. 184-186
    • Spulber, S.1    Bogdanovic, N.2    Romanitan, M.O.3    Bajenaru, O.A.4    Popescu, B.O.5
  • 59
    • 79960830822 scopus 로고    scopus 로고
    • Claudins: Control of barrier function and regulation in response to oxidant stress
    • Overgaard CE, Daugherty BL, Mitchell LA, Koval M (2011) Claudins: Control of barrier function and regulation in response to oxidant stress. Antioxid Redox Signal 15, 1179-1193.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 1179-1193
    • Overgaard, C.E.1    Daugherty, B.L.2    Mitchell, L.A.3    Koval, M.4
  • 61
    • 77957335213 scopus 로고    scopus 로고
    • Amyloid-beta1-42 induces reactive oxygen speciesmediated autophagic cell death in U87 and SH-SY5Y cells
    • Wang H, Ma J, Tan Y, Wang Z, Sheng C, Chen S, Ding J (2010) Amyloid-beta1-42 induces reactive oxygen speciesmediated autophagic cell death in U87 and SH-SY5Y cells. J Alzheimers Dis 21, 597-610.
    • (2010) J Alzheimers Dis , vol.21 , pp. 597-610
    • Wang, H.1    Ma, J.2    Tan, Y.3    Wang, Z.4    Sheng, C.5    Chen, S.6    Ding, J.7
  • 62
    • 81555200043 scopus 로고    scopus 로고
    • Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
    • Zlokovic BV (2011) Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci 12, 723-738.
    • (2011) Nat Rev Neurosci , vol.12 , pp. 723-738
    • Zlokovic, B.V.1
  • 63
    • 0032550221 scopus 로고    scopus 로고
    • Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions
    • Saitou M, Fujimoto K, Doi Y, Itoh M, Fujimoto T, Furuse M, Takano H, Noda T, Tsukita S (1998) Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions. J Cell Biol 141, 397-408.
    • (1998) J Cell Biol , vol.141 , pp. 397-408
    • Saitou, M.1    Fujimoto, K.2    Doi, Y.3    Itoh, M.4    Fujimoto, T.5    Furuse, M.6    Takano, H.7    Noda, T.8    Tsukita, S.9
  • 65
    • 0035897412 scopus 로고    scopus 로고
    • Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney i cells
    • Furuse M, Furuse K, Sasaki H, Tsukita S (2001) Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J Cell Biol 153, 263-272.
    • (2001) J Cell Biol , vol.153 , pp. 263-272
    • Furuse, M.1    Furuse, K.2    Sasaki, H.3    Tsukita, S.4
  • 67
    • 70449109156 scopus 로고    scopus 로고
    • Remodeling of the tight junction during recovery from exposure to hydrogen peroxide in kidney epithelial cells
    • Gonzalez JE, DiGeronimo RJ, Arthur DE, King JM (2009) Remodeling of the tight junction during recovery from exposure to hydrogen peroxide in kidney epithelial cells. Free Radic Biol Med 47, 1561-1569.
    • (2009) Free Radic Biol Med , vol.47 , pp. 1561-1569
    • Gonzalez, J.E.1    Digeronimo, R.J.2    Arthur, D.E.3    King, J.M.4


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