Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: Potential significance for tau protein phosphorylation

Neurochemistry International

Volumn 39, Issue 5-6, 2001, Pages 341-348

  Sheng, Jin G ^a,e   Jones, Richard A ^c   Zhou, Xue Q ^a   McGinness, John M ^a   Van Eldik, Linda J ^d   Mrak, Robert E ^b   Griffin, W Sue T ^a,c  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

^e SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; AT8; Interleukin 1; MAPK p38; Tau phosphorylation

Indexed keywords

INTERLEUKIN 1; ISOPROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN ANTIBODY; SYNAPTOPHYSIN; TAU PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CELL ACTIVATION; CONTROLLED STUDY; DYSTROPHY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENT CELL; MALE; MICROGLIA; NEURITE; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TISSUE LEVEL;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANIMALS; BLOTTING, WESTERN; BRAIN; FEMALE; HUMANS; INTERLEUKIN-1; MALE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TAU PROTEINS;

EID: 0034814057     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(01)00041-9     Document Type: Article

References (22)

1. Abnormally phosphorylated tau protein related to the formation of neurofibrillary tangles and neuropil threads in the cerebral cortex of sheep and goat
2. Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state
3. Association of an interleukin 1α polymorphism with Alzheimer's disease
4. Monoclonal antibody AT8 recognizes tau protein phosphorylated at both serine 202 and threonine 205
5. Brain interleukin-1 and S100 immunoreactivity is elevated in Down syndrome and Alzheimer's disease
6. Interleukin-1 expression in different plaque types in Alzheimer's disease: Significance in plaque evolution
7. Glial-neuronal interactions in Alzheimer's disease: The potential role of a cytokine cycle in disease progression
8. The pervasiveness of interleukin-1 in Alzheimer pathogenesis: A role for specific polymorphisms in disease risk
9. Association of early onset Alzheimer's disease with an interleukin-1 gene polymorphism
10. 2 biosynthesis stimulated by interleukin-1β
11. p38 Kinase is activated in Alzheimer's disease brain
12. Demonstration by fluorescence resonance energy transfer of a close association between activated MAP kinase and neurofibrillary tangles: Implications for MAP kinase activation in Alzheimer disease
13. The consortium to establish a registry for Alzheimer's disease, CERAD. Part II. Standardization of the neuropathological assessment of Alzheimer's disease
14. Glial cytokines in Alzheimer's disease. Review and pathogenic implications
15. Association of interleukin-1 gene polymorphisms with Alzheimer's disease
16. Towards an understanding of the signal transduction pathways for interleukin-1
17. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
18. Confirmation of the genetic association of interleukin-1A with early onset sporadic Alzheimer's disease
19. Reactivating kinase/p38 phosphorylates protein in vitro
20. + astrocytes with neurofibrillary tangle stage
21. Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo
22. Mitogen-activated protein kinase cascades and regulation of gene expression