Cytokine-stimulated inducible nitric oxide synthase expression in astroglia: Role of Erk mitogen-activated protein kinase and NF-κB

GLIA

Volumn 41, Issue 2, 2003, Pages 152-160

  Marcus, Joshua S ^a   Karackattu, Sharon L ^a   Fleegal, Melissa A ^a   Sumners, Colin ^a,b  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Astroglia; Cytokine; Inducible nitric oxide synthase; Mitogen activated protein kinase; NF B; Nitric oxide

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYTOKINE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; NITRIC OXIDE SYNTHASE; NITRITE; PYRROLIDINE DITHIOCARBAMATE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; ENZYME ACTIVITY; MACROGLIA; MALE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; RAT; TIME;

ANIMALS; ASTROCYTES; BRAIN; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOKINES; I-KAPPA B PROTEINS; INTERLEUKIN-1; MALE; MAP KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037440375     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/glia.10168     Document Type: Article

References (25)

1. Abe K, Saito H. 2000. The p44/42 mitogen-activated protein kinase cascade is involved in the induction and maintenance of astrocyte stellation mediated by protein kinase C. Neurosci Res 36:251-257.
2. Abraham E. 2000. NF-kappaB activation. Crit Care Med 28(Suppl 4):N100-N104.
3. Alpert D, Schwenger P, Han J, Vilcek J. 1999. Cell stress and MKK6b-mediated p38 MAP kinase activation inhibit tumor necrosis factor-induced IkappaB phosphorylation and NF kappaB activation. J Biol Chem 274:22176-22183.
4. Andrews NC, Faller DV. 1991. A rapid micropreparation technique for extraction of DNA binding proteins from limiting numbers of mammalian cells. Nucl Acids Res 19:2499.
5. mapk in a mouse macrophage cell line. Am J Physiol Cell Physiol 280:C441-C450.
6. Chan E, Morris K, Belisle J, Hill P, Remigio L, Brennan P, Riches D. 2001. Induction of inducible nitric oxide synthase-NO by lipoarabi-nomannan of mycobacterium tuberculosis is mediated by MEK1-ERK, MKK7-JNK, and NF-κB signaling pathways. Infect Immun 69:2001-2010.
7. Chandler LJ, Kopnisky K, Richards E, Crews FT, Sumners C. 1995. Angiotensin II decreases inducible nitric oxide synthase expression in rat astroglial cultures. Am J Physiol 268(3 Pt 1):C700-C707.
8. Choi J, Krushel LA, Crossin KL. 2001. NF-kappaB activation by N-CAM and cytokines in astrocytes is regulated by multiple protein kinases and redox modulation. Glia 33:45-56.
9. Da Silva J, Pierrat B, Mary JL, Lesslauer W. 1997. Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression in mouse astrocytes. J Biol Chem 272: 28373-28380.
10. Doi M, Shichiri M, Katsuyama K, Marumo F, Hirata, Y. 2000. Cytokine-activated p42/p44 MAP kinase is involved in inducible nitric oxide synthase gene expression independent from NF-κB activation in vascular smooth muscle cells. Hypertens Res 6:659-667.
11. Ghosh S, Karin M. 2002. Missing pieces in the NF-kappaB puzzle. Cell 109(Suppl):S81-S96.
12. Hirano M, Osada S, Aoki T, Hirai S, Hosaka M., Inoeu J, Ohno S. 1996. MEK kinase is involved in tumor necrosis factor α-induced NF-κB activation and degradation of IκB-α. J Biol Chem 271:13234-13238.
13. Hua LL, Zhao ML, Cosenza M, Kim MO, Huang H, Tanowitz HB, Brosnan CF, Lee SC. 2002. Role of mitogen-activated protein kinases in inducible nitric oxide synthase and TNFalpha expression in human fetal astrocytes. J Neuroimmunol 126:180-189.
14. Jiang B, Brecher P, Cohen RA. 2001. Persistent activation of nuclear factor-kappaB by interleukin-1beta and subsequent inducible NO synthase expression requires extracellular signal regulated kinase. Arterioscler Thromb Vasc Biol 21:1915-1920.
15. Kan H, Xie Z, Finkel M. 1999. TNF-α enhances cardiac myocyte NO production through MAP kinase-mediated NF-κB activation. Am J Physiol 277:H1641-H1646.
16. Kopnisky KL, Sumners C, Chandler LJ. 1997. Cytokine- and endotoxin-induced nitric oxide synthase in rat astroglial cultures: differential modulation by angiotensin II. J Neurochem 68:935-944.
17. Kopnisky KL, Sumners C. 2000. Angiotensin II-induced decrease in expression of inducible nitric oxide synthase in rat astroglial cultrues: role of protein kinase c. J Neurochem 74:613-620.
18. Kroncke KD, Fehsel K, Kolb-Bachofen V. 1997. Nitric oxide: cytotoxicity versus cytoprotection - how, why, when, and where? Nitric Oxide 1:107-120.
19. LaPointe MC, Isenovic E. 1999. Interleukin-1β regulation of inducible nitric oxide synthase and cyclooxygenase-2 involves the p42/44 and p38 MAPK signaling pathways in cardiac myocytes. Hypertension 33:276-282.
20. Lipton SA. 1999. Neuronal protection and destruction by NO. Cell Death Diff 6:943-951.
21. Liu L, Stamler JS. 1999. NO: an inhibitor of cell death. Cell Death Diff 6:937-942.
22. Neary JT, Kang Y, Bu Y, Yu E, Akong K, Peters CM. 1999. Mitogenic signaling by ATP/P2Y purinergic receptors in astrocytes: involvement of a calcium-independent protein kinase C, extracellular signal-regulated protein kinase pathway distinct from the phosphatidylinositol specific phospholipase C/calcium pathway. J Neurosci 19:4211-4220.
23. Nomura Y. 2001. NF-kappaB activation and IkappaB alpha dynamism involved in iNOS and chemokine induction in astroglial cells. Life Sci 68:1695-1701.
24. Pahan K, Namboodiri AM, Sheikh FG, Smith BT, Singh I. 1997. Increasing cAMP attenuates induction of inducible nitric-oxide synthase in rat primary astrocytes. J Biol Chem 272:7786-7791.
25. Pahan K, Liu X, McKinney MJ, Wood C, Sheikh FG, Raymond JR. 2000. Expression of a dominant-negative mutant of p21(ras) inhibits induction of nitric oxide synthase and activation of nuclear factor-kappaB in primary astrocytes. J Neurochem 74:2288-2295.