Regulation of tumor necrosis factor-α expression by CD40 ligation in BV-2 microglial cells

Journal of Neurochemistry

Volumn 80, Issue 1, 2002, Pages 197-206

  Jana, Malabendu ^a   Dasgupta, Subhajit ^a   Liu, Xiaojuan ^a   Pahan, Kalipada ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

C EBP ; CD40 ligation; Microglia; Nuclear factor B (NF B); Tumor necrosis factor (TNF )

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; CD40 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MUTANT PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GLIA CELL; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; RNA ANALYSIS; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBODIES; ANTIGENS, CD40; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CD40 LIGAND; CELL LINE; INTERFERON TYPE II; MICE; MICROGLIA; NF-KAPPA B; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 0036270560     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-3042.2001.00691.x     Document Type: Article

References (46)

1. Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins
2. Increased IL-12 production in progressive multiple sclerosis: Induction by activated CD4+ T cells via CD40 ligand
3. Soluble tumor necrosis factor receptor inhibits interleukin-12 production by stimulated human adult microglia cells in vitro
4. IkappaB interacts with the nuclear localization sequences of the subunits of NF-kappaB: A mechanism for cytoplasmic retention
5. Multiple sclerosis: Oligodendrocytes display cell death-related molecules in situ but do not undergo apoptosis
6. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
7. Mechanisms of immune injury in multiple sclerosis
8. Control of IkappaB-α proteolysis by site-specific, signal-induced phosphorylation
9. Multiple sclerosis: Fas signaling in oligodendrocyte cell death
10. A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA
11. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
12. Immune regulation by CD40 and its ligand GP39
13. CD40-CD40 ligand interactions in experimental allergic encephalomyetitis and multiple sclerosis
14. Microglia as mediators of inflammatory and degenerative diseases
15. The CD40 ligand: At the center of the immune universe?
16. Requirement of CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis
17. Nuclear factor-kappaB is a molecular target for sulforaphanemediated anti-inflammatory mechanisms
18. Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region
19. Activation of microglial cells by β-amyloid protein and interferon-γ
20. Interaction and functional collaboration of p300 and C/EBPβ
21. Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-β
22. Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages
23. N-Acetyl cysteine inhibits induction of NO production by endotoxin or cytokine stimulated rat peritaneal macrophages, C6 glial cells and astrocytes
24. Inhibitors of protein phosphatase 1 and 2A differentially regulate the expression of inducible nitric-oxide synthase in rat astrocytes and macrophages
25. Expression of a constitutively active form of phosphatidylinositol 3-kinase inhibits the induction of nitric oxide synthase in human astrocytes
26. ras inhibits induction of nitric oxide synthase and activation of nuclear factor-kappaB in primary astrocytes
27. Induction of nitric-oxide synthase and activation of NF-kappaB by interleukin-12 p40 in microglial cells
28. 2
29. Selective modulation of BV-2 microglial activation by prostaglandin E (2). Differential effects on endotoxin-stimulated cytokine induction
30. Multiple sclerosis: TNF revisited, with promise
31. An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis
32. CD40L blockade prevents autoimmune encephalomyelitis and hampers THI but not TH2 pathway of T cell differentiation
33. Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro
34. Association between tumor necrosis factor-α and disease progression in patients with multiple sclerosis
35. Lipopolysaccharide induces activation of CDI4-associated protein tyrosine kinase p53/56lyn
36. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kB and C/EBPβ
37. NF-kappaB controls expression of inhibitor IkappaB-α: Evidence for an inducible autoregulatory pathway
38. Activation of microglial cells by the CD40 pathway: Relevance to multiple sclerosis
39. Ligation of microglial CD40 results in p44/42 mitogen-activated protein kinase-dependent TNF-α production that is opposed by TGF-beta 1 and IL-10
40. Cytokine expression of macrophages in HIV-I-associated vacuolar myelopathy
41. Complex NF-kB interactions at the distal tumor necrosis factor promoter region in human monocytes
42. The pathophysiology of tumor necrosis factors
43. CCAAT/ enhancer binding protein is involved in the expression of the rumor necrosis factor gene in human monocytes
44. Lipopolysaccharide induction of the tumor necrosis factor-α promoter in human monocytic cells
45. A20 inhibits NF-kB activation downstream of multiple MAP3 kinases and interacts with the IkappaB signalosome
46. The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP- independent mechanism