-
1
-
-
84875354777
-
Alzheimer's Association. 2013 Alzheimer's disease facts and figures
-
Thies W, Bleiler L, Alzheimer's Association. 2013 Alzheimer's disease facts and figures. Alzheimers Dement 2013; 9:208-245.
-
(2013)
Alzheimers Dement
, vol.9
, pp. 208-245
-
-
Thies, W.1
Bleiler, L.2
-
2
-
-
77953518555
-
Alzheimer's disease: Clinical trials and drug development
-
Mangialasche F, Solomon A, Winblad B, et al. Alzheimer's disease: clinical trials and drug development. Lancet Neurol 2010; 9:702-716.
-
(2010)
Lancet Neurol
, vol.9
, pp. 702-716
-
-
Mangialasche, F.1
Solomon, A.2
Winblad, B.3
-
3
-
-
70349093083
-
Disease-modifying approach to the treatment of Alzheimer's disease: From alpha-secretase activators to gamma-secretase inhibitors and modulators
-
Panza F, Solfrizzi V, Frisardi V, et al. Disease-modifying approach to the treatment of Alzheimer's disease: from alpha-secretase activators to gamma-secretase inhibitors and modulators. Drugs Aging 2009; 26:537-555.
-
(2009)
Drugs Aging
, vol.26
, pp. 537-555
-
-
Panza, F.1
Solfrizzi, V.2
Frisardi, V.3
-
4
-
-
0032749171
-
Application of the National Institute on Aging (NIA)-Reagan Institute criteria for the neuro-pathological diagnosis of Alzheimer disease
-
Newell KL, Hyman BT, Growdon JH, Hedley-Whyte ET. Application of the National Institute on Aging (NIA)-Reagan Institute criteria for the neuro-pathological diagnosis of Alzheimer disease. J Neuropathol Exp Neurol 1999; 58:1147-1155.
-
(1999)
J Neuropathol Exp Neurol
, vol.58
, pp. 1147-1155
-
-
Newell, K.L.1
Hyman, B.T.2
Growdon, J.H.3
Hedley-Whyte, E.T.4
-
5
-
-
0035477333
-
The cell biology of Alzheimer's disease: Uncovering the secrets of secretases
-
Walter J, Kaether C, Steiner H, Haass C. The cell biology of Alzheimer's disease: uncovering the secrets of secretases. Curr Opin Neurobiol 2001; 11:585-590.
-
(2001)
Curr Opin Neurobiol
, vol.11
, pp. 585-590
-
-
Walter, J.1
Kaether, C.2
Steiner, H.3
Haass, C.4
-
6
-
-
0026646605
-
Isolation and quantification of soluble Alzheimer's p-peptide from biological fluids
-
Seubert P, Vigo-Pelfry C, Esch F, et al. Isolation and quantification of soluble Alzheimer's p-peptide from biological fluids. Nature 1996; 359: 325-327.
-
(1996)
Nature
, vol.359
, pp. 325-327
-
-
Seubert, P.1
Vigo-Pelfry, C.2
Esch, F.3
-
7
-
-
0028169925
-
Visualization of Ap42(43) and Ap40 in senile plaques with specific Ap monoclonals: Evidence that the initially deposited species is Ap42(43)
-
Iwatsubo T, Odaka A, Suzuki N, et al. Visualization of Ap42(43) and Ap40 in senile plaques with specific Ap monoclonals: evidence that the initially deposited species is Ap42(43). Neuron 1993; 13:45-53.
-
(1993)
Neuron
, vol.13
, pp. 45-53
-
-
Iwatsubo, T.1
Odaka, A.2
Suzuki, N.3
-
8
-
-
0025899041
-
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
-
Hardy J, Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 1991; 12:383-388.
-
(1991)
Trends Pharmacol Sci
, vol.12
, pp. 383-388
-
-
Hardy, J.1
Allsop, D.2
-
9
-
-
79953276681
-
The pathogenesis of Alzheimer's disease: A reevaluation of the 'Amyloid Cascade Hypothesis'
-
doi:10.4061/2011/630865
-
Armstrong RA. The pathogenesis of Alzheimer's disease: a reevaluation of the 'Amyloid Cascade Hypothesis'. Int J Alzheimers Dis 2011; 2011:630865. doi:10.4061/2011/630865.
-
(2011)
Int J Alzheimers Dis
, vol.2011
, pp. 630865
-
-
Armstrong, R.A.1
-
11
-
-
0028942632
-
Tau protein directly interacts with the amyloid p-protein precursor: Implications for Alzheimer's disease
-
Smith MA, Siedlak SL, Richey PL, et al. Tau protein directly interacts with the amyloid p-protein precursor: implications for Alzheimer's disease. Nat Med 1995; 1:365-369.
-
(1995)
Nat Med
, vol.1
, pp. 365-369
-
-
Smith, M.A.1
Siedlak, S.L.2
Richey, P.L.3
-
12
-
-
0027322817
-
P-amyloid protein precursor and T mRNA levels versus p-amyloid plaque and neurofibrillary tangles in the aged human brain
-
Oyama F, Shimada H, Oyama R, et al. p-amyloid protein precursor and T mRNA levels versus p-amyloid plaque and neurofibrillary tangles in the aged human brain. J Neurochem 1993; 60:1658-1664.
-
(1993)
J Neurochem
, vol.60
, pp. 1658-1664
-
-
Oyama, F.1
Shimada, H.2
Oyama, R.3
-
13
-
-
33746650412
-
Alzheimer's disease and the aging brain
-
Terry RD. Alzheimer's disease and the aging brain. J Geriatr Psychiatry Neurol 2006; 19:125-128.
-
(2006)
J Geriatr Psychiatry Neurol
, vol.19
, pp. 125-128
-
-
Terry, R.D.1
-
14
-
-
77951928742
-
The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia
-
Medical Research Council Cognitive Function and Ageing Study
-
McDonald JM, Savva GM, Brayne C, et al., Medical Research Council Cognitive Function and Ageing Study. The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. Brain 2010; 133:1328-1341.
-
(2010)
Brain
, vol.133
, pp. 1328-1341
-
-
McDonald, J.M.1
Savva, G.M.2
Brayne, C.3
-
15
-
-
49149124343
-
Amyloid-p protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
-
Shankar GM, Li S, Mehta TH, et al. Amyloid-p protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 2008; 14:837-842.
-
(2008)
Nat Med
, vol.14
, pp. 837-842
-
-
Shankar, G.M.1
Li, S.2
Mehta, T.H.3
-
16
-
-
84877254025
-
Passive antiamyloid immunotherapy in Alzheimer's disease: What are the most promising targets?
-
Moreth J, Mavoungou C, Schindowski K. Passive antiamyloid immunotherapy in Alzheimer's disease: what are the most promising targets? Immun Ageing 2013; 10:18.
-
(2013)
Immun Ageing
, vol.10
, pp. 18
-
-
Moreth, J.1
Mavoungou, C.2
Schindowski, K.3
-
17
-
-
33645038471
-
A specific amyloid-p protein assembly in the brain impairs memory
-
Lesne S, Koh MT, Kotilinek L, et al. A specific amyloid-p protein assembly in the brain impairs memory. Nature 2006; 440:352-357.
-
(2006)
Nature
, vol.440
, pp. 352-357
-
-
Lesne, S.1
Koh, M.T.2
Kotilinek, L.3
-
18
-
-
62649174753
-
Oligomeric amyloid p associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
-
Koffie RM, Meyer-Luehmann M, Hashimoto T, et al. Oligomeric amyloid p associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proc Natl Acad Sci USA 2009; 106:4012-4017.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 4012-4017
-
-
Koffie, R.M.1
Meyer-Luehmann, M.2
Hashimoto, T.3
-
19
-
-
84865529158
-
Dominantly Inherited Alzheimer Network. Clinical and biomarker changes in dominantly inherited Alzheimer's disease
-
Bateman RJ, Xiong C, Benzinger TL, et al., Dominantly Inherited Alzheimer Network. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med 2012; 367:795-804.
-
(2012)
N Engl J Med
, vol.367
, pp. 795-804
-
-
Bateman, R.J.1
Xiong, C.2
Benzinger, T.L.3
-
20
-
-
84875250937
-
Amyloid p deposition, neurodegenera-tion, and cognitive decline in sporadic Alzheimer's disease: A prospective cohort study
-
Australian Imaging Biomarkers and Lifestyle (AIBL) Research Group
-
Villemagne VL, Burnham S, Bourgeat P, et al., Australian Imaging Biomarkers and Lifestyle (AIBL) Research Group. Amyloid p deposition, neurodegenera-tion, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study. Lancet Neurol 2013; 12:357-367.
-
(2013)
Lancet Neurol
, vol.12
, pp. 357-367
-
-
Villemagne, V.L.1
Burnham, S.2
Bourgeat, P.3
-
21
-
-
84857558439
-
Immunotherapy for Alzheimer's disease: From antip-amyloid to tau-based immunization strategies
-
Panza F, Frisardi V, Solfrizzi V, et al. Immunotherapy for Alzheimer's disease: from antip-amyloid to tau-based immunization strategies. Immunotherapy 2012;4:213-238.
-
(2012)
Immunotherapy
, vol.4
, pp. 213-238
-
-
Panza, F.1
Frisardi, V.2
Solfrizzi, V.3
-
22
-
-
84885649629
-
Clinical trials of amyloid-based immunotherapy for Alzheimer's disease: End of beginning or beginning of end?
-
Li Y, Liu Y, Wang Z, Jiang Y. Clinical trials of amyloid-based immunotherapy for Alzheimer's disease: end of beginning or beginning of end? Expert Opin Biol Ther 2013; 13:1515-1522.
-
(2013)
Expert Opin Biol Ther
, vol.13
, pp. 1515-1522
-
-
Li, Y.1
Liu, Y.2
Wang, Z.3
Jiang, Y.4
-
23
-
-
84882258085
-
Immunotherapy in Alzheimer's disease: Do we have all the pieces of the puzzle?
-
Sarazin M, Dorothee G, de Souza LC, Aucouturier P. Immunotherapy in Alzheimer's disease: do we have all the pieces of the puzzle? Biol Psychiatry 2013; 74:329-332.
-
(2013)
Biol Psychiatry
, vol.74
, pp. 329-332
-
-
Sarazin, M.1
Dorothee, G.2
De Souza, L.C.3
Aucouturier, P.4
-
24
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk D, Barbour R, Dunn W, et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999;400:173-177.
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
-
25
-
-
0036780877
-
Amyloid-beta immunotherapy for Alzheimer's disease: The end of the beginning
-
Schenk D. Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning. Nat Rev Neurosci 2002; 3:824-828.
-
(2002)
Nat Rev Neurosci
, vol.3
, pp. 824-828
-
-
Schenk, D.1
-
26
-
-
11444267243
-
Evaluation of the safety and immuno-genicity of synthetic Abeta42 (AN1792) in patients with AD
-
Bayer AJ, Bullock R, Jones RW, et al. Evaluation of the safety and immuno-genicity of synthetic Abeta42 (AN1792) in patients with AD. Neurology 2005; 64:94-101.
-
(2005)
Neurology
, vol.64
, pp. 94-101
-
-
Bayer, A.J.1
Bullock, R.2
Jones, R.W.3
-
27
-
-
10744230547
-
Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization
-
Orgogozo JM, Gilman S, Dartigues JF, et al. Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology 2003; 61:46-54.
-
(2003)
Neurology
, vol.61
, pp. 46-54
-
-
Orgogozo, J.M.1
Gilman, S.2
Dartigues, J.F.3
-
28
-
-
1042265187
-
Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease
-
Ferrer I, Boada Rovira M, Sanchez Guerra ML, et al. Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease. Brain Pathol 2004; 14:11-20.
-
(2004)
Brain Pathol
, vol.14
, pp. 11-20
-
-
Ferrer, I.1
Boada Rovira, M.2
Sanchez Guerra, M.L.3
-
29
-
-
64549152492
-
Long-term follow-up of patients immunized with AN1792: Reduced functional decline in antibody responders
-
AN1792 (QS-21)-251 Study Team
-
Vellas B, Black R, Thai U, et al., AN1792 (QS-21)-251 Study Team. Long-term follow-up of patients immunized with AN1792: reduced functional decline in antibody responders. Curr Alzheimer Res 2009; 6:144-151.
-
(2009)
Curr Alzheimer Res
, vol.6
, pp. 144-151
-
-
Vellas, B.1
Black, R.2
Thai, U.3
-
30
-
-
19944429065
-
Ab vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease
-
Masliah E, Hansen L, Adame A, et al. Ab vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease. Neurology 2005; 64:129-131.
-
(2005)
Neurology
, vol.64
, pp. 129-131
-
-
Masliah, E.1
Hansen, L.2
Adame, A.3
-
31
-
-
34247113214
-
Absence of beta-amyloid deposits after immunization in Alzheimer disease with Lewy body dementia
-
Bombois S, Maurage CA, Gompel M, et al. Absence of beta-amyloid deposits after immunization in Alzheimer disease with Lewy body dementia. Arch Neurol 2007; 64:583-587.
-
(2007)
Arch Neurol
, vol.64
, pp. 583-587
-
-
Bombois, S.1
Maurage, C.A.2
Gompel, M.3
-
32
-
-
20944448555
-
Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial
-
Gilman S, Koller M, Black RS, et al. Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology 2005; 64:1553-1562.
-
(2005)
Neurology
, vol.64
, pp. 1553-1562
-
-
Gilman, S.1
Koller, M.2
Black, R.S.3
-
33
-
-
0038100154
-
Antibodies against b-amyloid slow cognitive decline in Alzheimer's disease
-
Hock C, Konietzko U, Streffer JR, et al. Antibodies against b-amyloid slow cognitive decline in Alzheimer's disease. Neuron 2003; 38:547-554.
-
(2003)
Neuron
, vol.38
, pp. 547-554
-
-
Hock, C.1
Konietzko, U.2
Streffer, J.R.3
-
34
-
-
0035943436
-
Formation of neurofibrillary tangles in P3011 tau transgenic mice induced by Ab42 fibrils
-
Gotz J, Chen F, van Dorpe J, Nitsch RM. Formation of neurofibrillary tangles in P3011 tau transgenic mice induced by Ab42 fibrils. Science 2001; 293:1491-1495.
-
(2001)
Science
, vol.293
, pp. 1491-1495
-
-
Gotz, J.1
Chen, F.2
Van Dorpe, J.3
Nitsch, R.M.4
-
36
-
-
4043167747
-
Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
-
Oddo S, Billings L, Kesslak JP, et al. Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron 2004;43:321-332.
-
(2004)
Neuron
, vol.43
, pp. 321-332
-
-
Oddo, S.1
Billings, L.2
Kesslak, J.P.3
-
37
-
-
47149112621
-
Long-term effects of Ab42 immunisation in Alzheimer's disease: Follow-up of a randomised, placebo-controlled Phase i trial
-
Holmes C, Boche D, Wilkinson D, et al. Long-term effects of Ab42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled Phase I trial. Lancet 2008; 372:216-223.
-
(2008)
Lancet
, vol.372
, pp. 216-223
-
-
Holmes, C.1
Boche, D.2
Wilkinson, D.3
-
38
-
-
76849091134
-
Can Alzheimer disease be prevented by amyloid-beta immunotherapy?
-
Lemere CA, Masliah E. Can Alzheimer disease be prevented by amyloid-beta immunotherapy? Nat Rev Neurol 2010; 6:108-119.
-
(2010)
Nat Rev Neurol
, vol.6
, pp. 108-119
-
-
Lemere, C.A.1
Masliah, E.2
-
39
-
-
0034884382
-
Etal. Immunization with a nontoxic/nonfibrillar amyloid-p homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice
-
Sigurdsson EM, Scholtzova H, Mehta PD, etal. Immunization with a nontoxic/nonfibrillar amyloid-p homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice. Am J Pathol 2001; 159:439-447.
-
(2001)
Am J Pathol
, vol.159
, pp. 439-447
-
-
Sigurdsson, E.M.1
Scholtzova, H.2
Mehta, P.D.3
-
41
-
-
56349165547
-
DNA epitope vaccine containing complement component C3d enhances antiamyloid-beta antibody production and polarizes the immune response towards a Th2 phenotype
-
Movsesyan N, Mkrtichyan M, Petrushina I, et al. DNA epitope vaccine containing complement component C3d enhances antiamyloid-beta antibody production and polarizes the immune response towards a Th2 phenotype. J Neuroimmunol 2008; 205:57-63.
-
(2008)
J Neuroimmunol
, vol.205
, pp. 57-63
-
-
Movsesyan, N.1
Mkrtichyan, M.2
Petrushina, I.3
-
42
-
-
84863430558
-
Intranasal inoculation with an adenovirus vaccine encoding ten repeats of Ap3-10 reduces AD-like pathology and cognitive impairment in Tg-APPswe/PSEN1dE9 mice
-
Li Y, Ma Y, Zong LX, et al. Intranasal inoculation with an adenovirus vaccine encoding ten repeats of Ap3-10 reduces AD-like pathology and cognitive impairment in Tg-APPswe/PSEN1dE9 mice. J Neuroimmunol 2012; 249: 16-26.
-
(2012)
J Neuroimmunol
, vol.249
, pp. 16-26
-
-
Li, Y.1
Ma, Y.2
Zong, L.X.3
-
43
-
-
0037424110
-
Reduction of p-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization
-
Frenkel D, Dewachter I, Van Leuven F, Solomon B. Reduction of p-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization. Vaccine 2003; 21:1060-1065.
-
(2003)
Vaccine
, vol.21
, pp. 1060-1065
-
-
Frenkel, D.1
Dewachter, I.2
Van Leuven, F.3
Solomon, B.4
-
44
-
-
10044263401
-
Gene vaccination to bias the immune response to amyloid-beta peptide as therapy for Alzheimer disease
-
Qu B, Rosenberg RN, Li L, et al. Gene vaccination to bias the immune response to amyloid-beta peptide as therapy for Alzheimer disease. Arch Neurol 2004; 61:1859-1864.
-
(2004)
Arch Neurol
, vol.61
, pp. 1859-1864
-
-
Qu, B.1
Rosenberg, R.N.2
Li, L.3
-
45
-
-
33745476486
-
Nonviral Abeta DNA vaccine therapy against Alzheimer's disease: Long-term effects and safety
-
Okura Y, Miyakoshi A, Kohyama K, etal. Nonviral Abeta DNA vaccine therapy against Alzheimer's disease: long-term effects and safety. Proc Natl Acad Sci USA 2006; 103:9619-9624.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 9619-9624
-
-
Okura, Y.1
Miyakoshi, A.2
Kohyama, K.3
-
46
-
-
67649207270
-
Vaccination with Ap-displaying virus-like particles reduces soluble and insoluble cerebral Ap and lowers plaque burden in APP transgenic mice
-
Bach P, Tschape JA, Kopietz F, et al. Vaccination with Ap-displaying virus-like particles reduces soluble and insoluble cerebral Ap and lowers plaque burden in APP transgenic mice. J Immunol 2008; 182:7613-7624.
-
(2008)
J Immunol
, vol.182
, pp. 7613-7624
-
-
Bach, P.1
Tschape, J.A.2
Kopietz, F.3
-
47
-
-
84884679996
-
Development of a new DNA vaccine for Alzheimer disease targeting a wide range of Ap species and amyloidogenic peptides
-
Matsumoto Y, Niimi N, Kohyama K. Development of a new DNA vaccine for Alzheimer disease targeting a wide range of Ap species and amyloidogenic peptides. PLoS One 2013; 8:e75203.
-
(2013)
PLoS One
, vol.8
-
-
Matsumoto, Y.1
Niimi, N.2
Kohyama, K.3
-
48
-
-
12444268257
-
Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from p-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide
-
Agadjanyan MG, Ghochikyan A, Petrushina I, et al. Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from p-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide. J Immunol 2005; 174:1580-1586.
-
(2005)
J Immunol
, vol.174
, pp. 1580-1586
-
-
Agadjanyan, M.G.1
Ghochikyan, A.2
Petrushina, I.3
-
49
-
-
36248941497
-
Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Ap species in amyloid precursor protein transgenic mice
-
Petrushina I, Ghochikyan A, Mktrichyan M, et al. Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Ap species in amyloid precursor protein transgenic mice. J Neurosci 2007; 27:12721-12731.
-
(2007)
J Neurosci
, vol.27
, pp. 12721-12731
-
-
Petrushina, I.1
Ghochikyan, A.2
Mktrichyan, M.3
-
50
-
-
11844265865
-
HSV amplicon-mediated Ap vaccination in Tg2576 mice: Differential antigen-specific immune responses
-
Bowers WJ, Mastrangelo MA, Stanley HA, et al. HSV amplicon-mediated Ap vaccination in Tg2576 mice: differential antigen-specific immune responses. Neurobiol Aging 2005; 26:393-407.
-
(2005)
Neurobiol Aging
, vol.26
, pp. 393-407
-
-
Bowers, W.J.1
Mastrangelo, M.A.2
Stanley, H.A.3
-
51
-
-
84884211555
-
Active vaccination with ankyrin G reduces p-amyloid pathology in APP transgenic mice
-
Santuccione AC, Merlini M, Shetty A, et al. Active vaccination with ankyrin G reduces p-amyloid pathology in APP transgenic mice. Mol Psychiatry 2013; 18:358-368.
-
(2013)
Mol Psychiatry
, vol.18
, pp. 358-368
-
-
Santuccione, A.C.1
Merlini, M.2
Shetty, A.3
-
52
-
-
84874901987
-
Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's isease: Prelude to a clinical trial
-
Davtyan H, Ghochikyan A, Petrushina I, etal. Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's isease: prelude to a clinical trial. J Neurosci 2013; 33:4923-4934.
-
(2013)
J Neurosci
, vol.33
, pp. 4923-4934
-
-
Davtyan, H.1
Ghochikyan, A.2
Petrushina, I.3
-
53
-
-
79959670013
-
The second-generation active Abeta immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects
-
Wiessner C, Wiederhold KH, Tissot AC, et al. The second-generation active Abeta immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects. J Neurosci 2011; 31:9323-9331.
-
(2011)
J Neurosci
, vol.31
, pp. 9323-9331
-
-
Wiessner, C.1
Wiederhold, K.H.2
Tissot, A.C.3
-
54
-
-
84862331908
-
Safety, tolerability, and antibody response of active Abeta immunotherapy with CAD106 in patients with Alzheimer's disease: Randomised, double-blind, placebo-controlled, first-inhuman study
-
Winblad B, Andreasen N, Minthon L, etal. Safety, tolerability, and antibody response of active Abeta immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-inhuman study. Lancet Neurol 2012; 11:597-604.
-
(2012)
Lancet Neurol
, vol.11
, pp. 597-604
-
-
Winblad, B.1
Andreasen, N.2
Minthon, L.3
-
55
-
-
67849102202
-
Antiamyloid-beta immunotherapy in Alzheimer's disease: ACC-001 clinical trials are ongoing
-
Ryan JM, Grundman M. Antiamyloid-beta immunotherapy in Alzheimer's disease: ACC-001 clinical trials are ongoing. J Alzheimers Dis 2009; 17:243.
-
(2009)
J Alzheimers Dis
, vol.17
, pp. 243
-
-
Ryan, J.M.1
Grundman, M.2
-
56
-
-
63249137056
-
Development of AFFITOPE vaccines for Alzheimer's disease (AD): From concept to clinical testing
-
Schneeberger A, Mandler M, Otawa O, et al. Development of AFFITOPE vaccines for Alzheimer's disease (AD): from concept to clinical testing. J Nutr Health Aging 2009; 13:264-267.
-
(2009)
J Nutr Health Aging
, vol.13
, pp. 264-267
-
-
Schneeberger, A.1
Mandler, M.2
Otawa, O.3
-
57
-
-
84886281639
-
Advances in the development of vaccines for Alzheimer's disease
-
Lambracht-Washington D, Rosenberg RN. Advances in the development of vaccines for Alzheimer's disease. Discov Med 2013; 15:319-326.
-
(2013)
Discov Med
, vol.15
, pp. 319-326
-
-
Lambracht-Washington, D.1
Rosenberg, R.N.2
-
58
-
-
84886937126
-
Immunotherapy for Alzheimer's disease: Hoops and hurdles
-
Lemere CA. Immunotherapy for Alzheimer's disease: hoops and hurdles. Mol Neurodegener 2013; 8:36.
-
(2013)
Mol Neurodegener
, vol.8
, pp. 36
-
-
Lemere, C.A.1
-
59
-
-
0033835996
-
Peripherally administered antibodies against amyloid p-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
-
Bard F, Cannon C, Barbour R, et al. Peripherally administered antibodies against amyloid p-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 2000; 6:916-919.
-
(2000)
Nat Med
, vol.6
, pp. 916-919
-
-
Bard, F.1
Cannon, C.2
Barbour, R.3
-
60
-
-
33744499734
-
Mechanisms of A beta plaque clearance following passive Abeta immunization
-
Morgan D. Mechanisms of A beta plaque clearance following passive Abeta immunization. Neurodegener Dis 2005; 2:261-266.
-
(2005)
Neurodegener Dis
, vol.2
, pp. 261-266
-
-
Morgan, D.1
-
61
-
-
80053385682
-
Antip-amyloid immunotherapy for Alzheimer's disease: Focus on bapineuzumab
-
Panza F, Frisardi V, Imbimbo BP, et al. Antip-amyloid immunotherapy for Alzheimer's disease: focus on bapineuzumab. Curr Alzheimer Res 2011; 8:808-817.
-
(2011)
Curr Alzheimer Res
, vol.8
, pp. 808-817
-
-
Panza, F.1
Frisardi, V.2
Imbimbo, B.P.3
-
62
-
-
84856608579
-
Solanezumab for the treatment of mild-to-moderate Alzheimer's disease
-
Imbimbo BP, Ottonello S, Frisardi V, et al. Solanezumab for the treatment of mild-to-moderate Alzheimer's disease. Expert Rev Clin Immunol 2012; 8:135-149.
-
(2012)
Expert Rev Clin Immunol
, vol.8
, pp. 135-149
-
-
Imbimbo, B.P.1
Ottonello, S.2
Frisardi, V.3
-
63
-
-
84878927746
-
Bapineuzumab and solanezumab for Alzheimer's disease: Is the 'amyloid cascade hypothesis' still alive?
-
Tayeb HO, Murray ED, Price BH, Tarazi Fl. Bapineuzumab and solanezumab for Alzheimer's disease: is the 'amyloid cascade hypothesis' still alive? Expert Opin Biol Ther 2013; 13:1075-1084.
-
(2013)
Expert Opin Biol Ther
, vol.13
, pp. 1075-1084
-
-
Tayeb, H.O.1
Murray, E.D.2
Price, B.H.3
Fl, T.4
-
64
-
-
79960817113
-
Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer's Association Research Roundtable Workgroup
-
Sperling RA, Jack CR Jr, Black SE, et al. Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup. Alzheimers Dement 2011; 7:367-385.
-
(2011)
Alzheimers Dement
, vol.7
, pp. 367-385
-
-
Sperling, R.A.1
Jack Jr., C.R.2
Black, S.E.3
-
65
-
-
73349091534
-
A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease
-
Salloway S, Sperling R, Gilman S, et al. A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology 2009; 73:2061-2070.
-
(2009)
Neurology
, vol.73
, pp. 2061-2070
-
-
Salloway, S.1
Sperling, R.2
Gilman, S.3
-
66
-
-
77949300796
-
11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: A phase 2, double-blind, placebo-controlled, ascending-dose study
-
Rinne JO, Brooks DJ, Rossor MN, etal. 11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study. Lancet Neurol 2010; 9:363-372.
-
(2010)
Lancet Neurol
, vol.9
, pp. 363-372
-
-
Rinne, J.O.1
Brooks, D.J.2
Rossor, M.N.3
-
67
-
-
84863750982
-
Effect of immunotherapy with bapineuzumab on cerebrospinal fluid biomarker levels in patients with mild to moderate Alzheimer disease
-
AAB-001201/202 Investigators
-
Blennow K, Zetterberg H, Rinne JO, et al. AAB-001201/202 Investigators. Effect of immunotherapy with bapineuzumab on cerebrospinal fluid biomarker levels in patients with mild to moderate Alzheimer disease. Arch Neurol 2012; 69:1002-1010.
-
(2012)
Arch Neurol
, vol.69
, pp. 1002-1010
-
-
Blennow, K.1
Zetterberg, H.2
Rinne, J.O.3
-
68
-
-
37849012608
-
Antibody capture of soluble Abeta does not reduce cortical Abeta amyloidosis in the PDAPP mouse
-
Seubert P, Barbour R, Khan K, etal. Antibody capture of soluble Abeta does not reduce cortical Abeta amyloidosis in the PDAPP mouse. Neurodegener Dis 2008; 5:65-71.
-
(2008)
Neurodegener Dis
, vol.5
, pp. 65-71
-
-
Seubert, P.1
Barbour, R.2
Khan, K.3
-
69
-
-
84863221661
-
Safety and biomarker effects of solanezumab in patients with Alzheimer's disease
-
Farlow M, Arnold SE, van Dyck CH, et al. Safety and biomarker effects of solanezumab in patients with Alzheimer's disease. Alzheimers Dement 2012; 8:261-271.
-
(2012)
Alzheimers Dement
, vol.8
, pp. 261-271
-
-
Farlow, M.1
Arnold, S.E.2
Van Dyck, C.H.3
-
70
-
-
77951086901
-
Safety and changes in plasma and cerebrospinal fluid amyloid-beta after a single administration of an amyloid-beta monoclonal antibody in subjects with Alzheimer disease
-
Siemers ER, Friedrich S, Dean RA, et al. Safety and changes in plasma and cerebrospinal fluid amyloid-beta after a single administration of an amyloid-beta monoclonal antibody in subjects with Alzheimer disease. Clin Neuropharmacol 2010; 33:67-73.
-
(2010)
Clin Neuropharmacol
, vol.33
, pp. 67-73
-
-
Siemers, E.R.1
Friedrich, S.2
Dean, R.A.3
-
71
-
-
84865077476
-
News focus: Stopping Alzheimer's before it starts
-
Miller G. News focus: stopping Alzheimer's before it starts. Science 2012; 337:790-792.
-
(2012)
Science
, vol.337
, pp. 790-792
-
-
Miller, G.1
-
72
-
-
34447322271
-
Research criteria for the diagnosis of Alzheimer's disease: Revising the NINCDS-ADRDA criteria
-
Dubois B, Feldman HH, Jacova C, etal. Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 2007; 6:734-746.
-
(2007)
Lancet Neurol
, vol.6
, pp. 734-746
-
-
Dubois, B.1
Feldman, H.H.2
Jacova, C.3
-
73
-
-
77957951112
-
Revising the definition of Alzheimer's disease: A new lexicon
-
Dubois B, Feldman HH, Jacova C, etal. Revising the definition of Alzheimer's disease: a new lexicon. Lancet Neurol 2010; 9:1118-1127.
-
(2010)
Lancet Neurol
, vol.9
, pp. 1118-1127
-
-
Dubois, B.1
Feldman, H.H.2
Jacova, C.3
-
74
-
-
84855780598
-
Gantenerumab: A novel human anti-Ap antibody demonstrates sustained cerebral amyloid-p binding and elicits cell-mediated removal of human amyloid-p
-
Bohrmann B, Baumann K, Benz J, etal. Gantenerumab: a novel human anti-Ap antibody demonstrates sustained cerebral amyloid-p binding and elicits cell-mediated removal of human amyloid-p. J Alzheimers Dis 2012; 28:49-69.
-
(2012)
J Alzheimers Dis
, vol.28
, pp. 49-69
-
-
Bohrmann, B.1
Baumann, K.2
Benz, J.3
-
75
-
-
84863115941
-
Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab
-
Ostrowitzki S, Deptula D, Thurfjell L, etal. Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab. Arch Neurol 2012; 69:198-207.
-
(2012)
Arch Neurol
, vol.69
, pp. 198-207
-
-
Ostrowitzki, S.1
Deptula, D.2
Thurfjell, L.3
-
76
-
-
84863803152
-
Gantenerumab for the treatment of Alzheimer's disease
-
Delrieu J, Ousset PJ, Vellas B. Gantenerumab for the treatment of Alzheimer's disease. Expert Opin Biol Ther 2012; 12:1077-1086.
-
(2012)
Expert Opin Biol Ther
, vol.12
, pp. 1077-1086
-
-
Delrieu, J.1
Ousset, P.J.2
Vellas, B.3
-
77
-
-
84878794559
-
Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network
-
Morris JC, Aisen PS, Bateman RJ, et al. Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network. Clin Investig 2012; 2:975-984.
-
(2012)
Clin Investig
, vol.2
, pp. 975-984
-
-
Morris, J.C.1
Aisen, P.S.2
Bateman, R.J.3
-
78
-
-
84863245510
-
39-week toxicity and toxicokinetic study of ponezumab (PF-04360365) in cynomolgus monkeys with 12-week recovery period
-
Freeman GB, Lin JC, Pons J, Raha NM. 39-week toxicity and toxicokinetic study of ponezumab (PF-04360365) in cynomolgus monkeys with 12-week recovery period. J Alzheimers Dis 2012; 28:531-541.
-
(2012)
J Alzheimers Dis
, vol.28
, pp. 531-541
-
-
Freeman, G.B.1
Lin, J.C.2
Pons, J.3
Raha, N.M.4
-
79
-
-
84872970450
-
Safety and pharmacology of ponezumab (PF-04360365) after a single 10-min intravenous infusion in subjects with mild to moderate Alzheimer disease
-
Burstein AH, Zhao Q, Ross J, et al. Safety and pharmacology of ponezumab (PF-04360365) after a single 10-min intravenous infusion in subjects with mild to moderate Alzheimer disease. Clin Neuropharmacol 2013; 36:8-13.
-
(2013)
Clin Neuropharmacol
, vol.36
, pp. 8-13
-
-
Burstein, A.H.1
Zhao, Q.2
Ross, J.3
-
80
-
-
84872960603
-
Safety and pharmacology of a single intravenous dose of ponezumab in subjects with mi Id-to-moderate Alzheimer disease: A phase I, randomized, placebo-controlled, double-blind, dose-escalation study
-
Landen JW, Zhao Q, Cohen S, et al. Safety and pharmacology of a single intravenous dose of ponezumab in subjects with mi Id-to-moderate Alzheimer disease: a phase I, randomized, placebo-controlled, double-blind, dose-escalation study. Clin Neuropharmacol 2013; 36:14-23.
-
(2013)
Clin Neuropharmacol
, vol.36
, pp. 14-23
-
-
Landen, J.W.1
Zhao, Q.2
Cohen, S.3
-
81
-
-
84863693043
-
An effector-reduced antip-amyloid (Ap) antibody with unique Ap binding properties promotes neuroprotection and glial engulfment of Ap
-
Adolfsson O, Pihlgren M, Toni N, etal. An effector-reduced antip-amyloid (Ap) antibody with unique Ap binding properties promotes neuroprotection and glial engulfment of Ap. J Neurosci 2012; 32:9677-9689.
-
(2012)
J Neurosci
, vol.32
, pp. 9677-9689
-
-
Adolfsson, O.1
Pihlgren, M.2
Toni, N.3
-
82
-
-
84873487586
-
Genentech's Alzheimer's antibody trial to study disease prevention
-
Garber K. Genentech's Alzheimer's antibody trial to study disease prevention. Nat Biotechnol 2012; 30:731-732.
-
(2012)
Nat Biotechnol
, vol.30
, pp. 731-732
-
-
Garber, K.1
-
83
-
-
16044365171
-
The E280A presenilin 1 Alzheimer mutation produces increased Ap42 deposition and severe cerebellar pathology
-
Lemere CA, Lopera F, Kosik KS, et al. The E280A presenilin 1 Alzheimer mutation produces increased Ap42 deposition and severe cerebellar pathology. Nat Med 1996; 2:1146-1150.
-
(1996)
Nat Med
, vol.2
, pp. 1146-1150
-
-
Lemere, C.A.1
Lopera, F.2
Kosik, K.S.3
-
84
-
-
8044226013
-
Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation
-
Lopera F, Ardilla A, Martinez A, etal. Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation. JAMA 1997; 277:793-799.
-
(1997)
JAMA
, vol.277
, pp. 793-799
-
-
Lopera, F.1
Ardilla, A.2
Martinez, A.3
-
85
-
-
79851496064
-
Antibody-based therapy in Alzheimer's disease
-
Pul R, Dodel R, Stangel M. Antibody-based therapy in Alzheimer's disease. Expert Opin Biol Ther 2011; 11:343-357.
-
(2011)
Expert Opin Biol Ther
, vol.11
, pp. 343-357
-
-
Pul, R.1
Dodel, R.2
Stangel, M.3
-
86
-
-
84878427627
-
Intravenous immunoglobulin and Alzheimer's disease: What now?
-
Loeffler DA. Intravenous immunoglobulin and Alzheimer's disease: what now? J Neuroinflammation 2013; 10:70.
-
(2013)
J Neuroinflammation
, vol.10
, pp. 70
-
-
Loeffler, D.A.1
-
87
-
-
84876307732
-
Intravenous immunoglobulin for treatment of mild-to-moderate Alzheimer's disease: A phase 2, randomised, double-blind, placebo-controlled, dose-finding trial
-
Dodel R, Rominger A, Bartenstein P, et al. Intravenous immunoglobulin for treatment of mild-to-moderate Alzheimer's disease: a phase 2, randomised, double-blind, placebo-controlled, dose-finding trial. Lancet Neurol 2013; 12:233-243.
-
(2013)
Lancet Neurol
, vol.12
, pp. 233-243
-
-
Dodel, R.1
Rominger, A.2
Bartenstein, P.3
-
88
-
-
33645220400
-
Targeting amyloid-b peptide (Ap) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Ap precursor protein (APP) transgenic mice
-
Lee EB, Leng LZ, Zhang B, et al. Targeting amyloid-b peptide (Ap) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Ap precursor protein (APP) transgenic mice. J Biol Chem 2006; 281:4292-4299.
-
(2006)
J Biol Chem
, vol.281
, pp. 4292-4299
-
-
Lee, E.B.1
Leng, L.Z.2
Zhang, B.3
-
89
-
-
33846135452
-
Monoclonal antibodies that target pathological assemblies of Ap
-
Lambert MP, Velasco PT, Chang L, et al. Monoclonal antibodies that target pathological assemblies of Ap. J Neurochem 2007; 100:23-35.
-
(2007)
J Neurochem
, vol.100
, pp. 23-35
-
-
Lambert, M.P.1
Velasco, P.T.2
Chang, L.3
-
90
-
-
84862816040
-
Passive immunization against pyroglutamate-3 amyloid-p reduces plaque burden in Alzheimer's-like transgenic mice: A pilot study
-
Frost JL, Liu B, Kleinschmidt M, et al. Passive immunization against pyroglutamate-3 amyloid-p reduces plaque burden in Alzheimer's-like transgenic mice: a pilot study. Neurodegenerative Dis 2012; 10:265-270.
-
(2012)
Neurodegenerative Dis
, vol.10
, pp. 265-270
-
-
Frost, J.L.1
Liu, B.2
Kleinschmidt, M.3
-
91
-
-
84871887566
-
AntiapoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Ap amyloidosis
-
Kim J, Eltorai AE, Jiang H, et al. AntiapoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Ap amyloidosis. J Exp Med 2012; 209:2149-2156.
-
(2012)
J Exp Med
, vol.209
, pp. 2149-2156
-
-
Kim, J.1
Eltorai, A.E.2
Jiang, H.3
-
92
-
-
84872144291
-
A plaque-specific antibody clears existing p-amyloid plaques in Alzheimer's disease mice
-
Demattos RB, Lu J, Tang Y, et al. A plaque-specific antibody clears existing p-amyloid plaques in Alzheimer's disease mice. Neuron 2012; 76:908-920.
-
(2012)
Neuron
, vol.76
, pp. 908-920
-
-
Demattos, R.B.1
Lu, J.2
Tang, Y.3
-
93
-
-
84868113477
-
Immunization targeting a minor plaque constituent clears p-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model
-
Morales-Corraliza J, Schmidt SD, Mazzella MJ, et al. Immunization targeting a minor plaque constituent clears p-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model. Neurobiol Aging 2013; 34:137-145.
-
(2013)
Neurobiol Aging
, vol.34
, pp. 137-145
-
-
Morales-Corraliza, J.1
Schmidt, S.D.2
Mazzella, M.J.3
|