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Volumn 27, Issue 3, 2007, Pages 627-633

Aβ40 inhibits amyloid deposition in vivo

Author keywords

Aggregation; Alzheimer's disease; Amyloid ; Cerebral amyloid angiopathy; Premature death; Transgenic mice

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID; AMYLOID BETA PROTEIN; PEPTIDE FRAGMENT;

EID: 33846435323     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4849-06.2007     Document Type: Article
Times cited : (321)

References (51)
  • 1
    • 0033616590 scopus 로고    scopus 로고
    • Ancolio K, Dumanchin C, Barelli H, Warter JM, Brice A, Campion D, Frebourg T, Checler F (1999) Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 → Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease. Proc Natl Acad Sci USA 96:4119-4124.
    • Ancolio K, Dumanchin C, Barelli H, Warter JM, Brice A, Campion D, Frebourg T, Checler F (1999) Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 → Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease. Proc Natl Acad Sci USA 96:4119-4124.
  • 4
    • 0037551741 scopus 로고    scopus 로고
    • Protofibrils, pores, fibrils, and neurodegeneration: Separating the responsible protein aggregates from the innocent bystanders
    • Caughey B, Lansbury PT (2003) Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annu Rev Neurosci 26:267-298.
    • (2003) Annu Rev Neurosci , vol.26 , pp. 267-298
    • Caughey, B.1    Lansbury, P.T.2
  • 6
    • 0037312858 scopus 로고    scopus 로고
    • In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories
    • D'Amore JD, Kajdasz ST, McLellan ME, Bacskai BJ, Stern EA, Hyman BT (2003) In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories. J Neuropathol Exp Neurol 62:137-145.
    • (2003) J Neuropathol Exp Neurol , vol.62 , pp. 137-145
    • D'Amore, J.D.1    Kajdasz, S.T.2    McLellan, M.E.3    Bacskai, B.J.4    Stern, E.A.5    Hyman, B.T.6
  • 7
    • 33645578379 scopus 로고    scopus 로고
    • Delection of presenilin 1 hydrophilic loop sequence leads to impaired γ-secretase activity and exacerbated amyloid pathology
    • Deng Y, Tarassishin L, Kallhoff V, Peethumnongsin E, Wu L, Li Y, Zheng H (2006) Delection of presenilin 1 hydrophilic loop sequence leads to impaired γ-secretase activity and exacerbated amyloid pathology. J Neurosci 26:3845-3854.
    • (2006) J Neurosci , vol.26 , pp. 3845-3854
    • Deng, Y.1    Tarassishin, L.2    Kallhoff, V.3    Peethumnongsin, E.4    Wu, L.5    Li, Y.6    Zheng, H.7
  • 10
    • 3242809725 scopus 로고    scopus 로고
    • A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster
    • Finelli A, Kelkar A, Song HJ, Yang H, Konsolaki M (2004) A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster. Mol Cell Neurosci 26:365-375.
    • (2004) Mol Cell Neurosci , vol.26 , pp. 365-375
    • Finelli, A.1    Kelkar, A.2    Song, H.J.3    Yang, H.4    Konsolaki, M.5
  • 12
    • 22544481733 scopus 로고    scopus 로고
    • The bad seed in Alzheimer's disease
    • Fryer JD, Holtzman DM (2005) The bad seed in Alzheimer's disease. Neuron 47:167-168.
    • (2005) Neuron , vol.47 , pp. 167-168
    • Fryer, J.D.1    Holtzman, D.M.2
  • 13
    • 15244340676 scopus 로고    scopus 로고
    • Human apolipoprotein E4 alters the amyloid-β 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model
    • Fryer JD, Simmons K, Parsadanian M, Bales KR, Paul SM, Sullivan PM, Holtzman DM (2005) Human apolipoprotein E4 alters the amyloid-β 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. J Neurosci 25:2803-2810.
    • (2005) J Neurosci , vol.25 , pp. 2803-2810
    • Fryer, J.D.1    Simmons, K.2    Parsadanian, M.3    Bales, K.R.4    Paul, S.M.5    Sullivan, P.M.6    Holtzman, D.M.7
  • 14
    • 33344463679 scopus 로고    scopus 로고
    • Common mechanisms of amyloid oligomer pathogenesis in degenerative disease
    • Glabe CG (2006) Common mechanisms of amyloid oligomer pathogenesis in degenerative disease. Neurobiol Aging 27:570-575.
    • (2006) Neurobiol Aging , vol.27 , pp. 570-575
    • Glabe, C.G.1
  • 15
    • 0028915895 scopus 로고
    • Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43)
    • Gravina SA, Ho L, Eckman CB, Long KE, Otvos Jr L, Younkin LH, Suzuki N, Younkin SG (1995) Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43). J Biol Chem 270:7013-7016.
    • (1995) J Biol Chem , vol.270 , pp. 7013-7016
    • Gravina, S.A.1    Ho, L.2    Eckman, C.B.3    Long, K.E.4    Otvos Jr, L.5    Younkin, L.H.6    Suzuki, N.7    Younkin, S.G.8
  • 16
    • 0030798816 scopus 로고    scopus 로고
    • Diagnosis of cerebral amyloid angiopathy. Sensitivity and specificity of cortical biopsy
    • Greenberg SM, Vonsattel JP (1997) Diagnosis of cerebral amyloid angiopathy. Sensitivity and specificity of cortical biopsy. Stroke 28:1418-1422.
    • (1997) Stroke , vol.28 , pp. 1418-1422
    • Greenberg, S.M.1    Vonsattel, J.P.2
  • 17
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297:353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 18
    • 0033598697 scopus 로고    scopus 로고
    • Interaction between A beta(1-42) and A beta(1-40) in Alzheimer's beta-amyloid fibril formation in vitro
    • Hasegawa K, Yamaguchi I, Omata S, Gejyo F, Naiki H (1999) Interaction between A beta(1-42) and A beta(1-40) in Alzheimer's beta-amyloid fibril formation in vitro. Biochemistry 38:15514-15521.
    • (1999) Biochemistry , vol.38 , pp. 15514-15521
    • Hasegawa, K.1    Yamaguchi, I.2    Omata, S.3    Gejyo, F.4    Naiki, H.5
  • 19
    • 0035950270 scopus 로고    scopus 로고
    • beta-Synuclein inhibits alpha-synuclein aggregation: A possible role as an antiparkinsonian factor
    • Hashimoto M, Rockenstein E, Mante M, Mallory M, Masliah E (2001) beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an antiparkinsonian factor. Neuron 32:213-223.
    • (2001) Neuron , vol.32 , pp. 213-223
    • Hashimoto, M.1    Rockenstein, E.2    Mante, M.3    Mallory, M.4    Masliah, E.5
  • 23
    • 0035863055 scopus 로고    scopus 로고
    • Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease
    • Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG (2001) Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci 21:372-381.
    • (2001) J Neurosci , vol.21 , pp. 372-381
    • Kawarabayashi, T.1    Younkin, L.H.2    Saido, T.C.3    Shoji, M.4    Ashe, K.H.5    Younkin, S.G.6
  • 24
    • 2542455537 scopus 로고    scopus 로고
    • Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease
    • Klein WL, Stine Jr WB, Teplow DB (2004) Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease. Neurobiol Aging 25:569-580.
    • (2004) Neurobiol Aging , vol.25 , pp. 569-580
    • Klein, W.L.1    Stine Jr, W.B.2    Teplow, D.B.3
  • 25
    • 0242362596 scopus 로고    scopus 로고
    • Beta-amyloid protein oligomers induced by metal ions and acid pH are distinct from those generated by slow spontaneous ageing at neutral pH
    • Klug GM, Losic D, Subasinghe SS, Aguilar MI, Martin LL, Small DH (2003) Beta-amyloid protein oligomers induced by metal ions and acid pH are distinct from those generated by slow spontaneous ageing at neutral pH. Eur J Biochem 270:4282-4293.
    • (2003) Eur J Biochem , vol.270 , pp. 4282-4293
    • Klug, G.M.1    Losic, D.2    Subasinghe, S.S.3    Aguilar, M.I.4    Martin, L.L.5    Small, D.H.6
  • 26
    • 3142512452 scopus 로고    scopus 로고
    • Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration
    • Koo EH, Kopan R (2004) Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. Nat Med [Suppl] 10:S26-S33.
    • (2004) Nat Med , vol.10 , Issue.SUPPL.
    • Koo, E.H.1    Kopan, R.2
  • 29
    • 0041825430 scopus 로고    scopus 로고
    • Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores
    • Lashuel HA, Hartley DM, Petre BM, Wall JS, Simon MN, Walz T, Lansbury Jr PT (2003) Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores. J Mol Biol 332:795-808.
    • (2003) J Mol Biol , vol.332 , pp. 795-808
    • Lashuel, H.A.1    Hartley, D.M.2    Petre, B.M.3    Wall, J.S.4    Simon, M.N.5    Walz, T.6    Lansbury Jr, P.T.7
  • 31
    • 0346101885 scopus 로고    scopus 로고
    • Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
    • Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sun X, Frosch MP, Selkoe DJ (2003) Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron 40:1087-1093.
    • (2003) Neuron , vol.40 , pp. 1087-1093
    • Leissring, M.A.1    Farris, W.2    Chang, A.Y.3    Walsh, D.M.4    Wu, X.5    Sun, X.6    Frosch, M.P.7    Selkoe, D.J.8
  • 37
    • 0032953541 scopus 로고    scopus 로고
    • Premature death in transgenic mice that overexpress a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis
    • Moechars D, Lorent K, Van Leuven F (1999a) Premature death in transgenic mice that overexpress a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis. Neuroscience 91:819-830.
    • (1999) Neuroscience , vol.91 , pp. 819-830
    • Moechars, D.1    Lorent, K.2    Van Leuven, F.3
  • 41
    • 0034609561 scopus 로고    scopus 로고
    • Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein
    • Rochet JC, Conway KA, Lansbury Jr PT (2000) Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein. Biochemistry 39:10619-10626.
    • (2000) Biochemistry , vol.39 , pp. 10619-10626
    • Rochet, J.C.1    Conway, K.A.2    Lansbury Jr, P.T.3
  • 44
    • 0034568802 scopus 로고    scopus 로고
    • Intramembrane proteolysis by presenilins
    • Steiner H, Haass C (2000) Intramembrane proteolysis by presenilins. Nat Rev Mol Cell Biol 1:217-224.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 217-224
    • Steiner, H.1    Haass, C.2
  • 45
    • 7044220336 scopus 로고    scopus 로고
    • Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches
    • Tsai J, Grutzendler J, Duff K, Gan WB (2004) Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nat Neurosci 7:1181-1183.
    • (2004) Nat Neurosci , vol.7 , pp. 1181-1183
    • Tsai, J.1    Grutzendler, J.2    Duff, K.3    Gan, W.B.4
  • 46
    • 30344478220 scopus 로고    scopus 로고
    • Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice
    • Van Dooren T, Muyllaert D, Borghgraef P, Cresens A, Devijver H, Van der Auwera I, Wera S, Dewachter I, Van Leuven F (2006) Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice. Am J Pathol 168:245-260.
    • (2006) Am J Pathol , vol.168 , pp. 245-260
    • Van Dooren, T.1    Muyllaert, D.2    Borghgraef, P.3    Cresens, A.4    Devijver, H.5    Van der Auwera, I.6    Wera, S.7    Dewachter, I.8    Van Leuven, F.9
  • 49
    • 0032105394 scopus 로고    scopus 로고
    • The role of A beta 42 in Alzheimer's disease
    • Younkin SG (1998) The role of A beta 42 in Alzheimer's disease. J Physiol (Paris) 92:289-292.
    • (1998) J Physiol (Paris) , vol.92 , pp. 289-292
    • Younkin, S.G.1
  • 50
    • 33845655221 scopus 로고    scopus 로고
    • Presenilin/gamma-secretase activity regulates protein clearance from the endocytic recycling compartment
    • Zhang M, Haapasalo A, Kim DY, Ingano LA, Pettingell WH, Kovacs DM (2006) Presenilin/gamma-secretase activity regulates protein clearance from the endocytic recycling compartment. FASEB J 20:1176-1178.
    • (2006) FASEB J , vol.20 , pp. 1176-1178
    • Zhang, M.1    Haapasalo, A.2    Kim, D.Y.3    Ingano, L.A.4    Pettingell, W.H.5    Kovacs, D.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.