Control of JNK for an activation of NADPH oxidase in LPS-stimulated BV2 microglia

Archives of Pharmacal Research

Volumn 35, Issue 4, 2012, Pages 709-715

  Han, Jung Eun ^a   Choi, Ji Woong ^a  

^a Gachon University College of Medicine   (South Korea)

Author keywords

4 (2 aminoethyl)benzenesulfonylfluoride; Diphenyleneiodonium chloride; Gp91phox; JIP; P47phox; SP600125

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; GLYCOPROTEIN GP 91; LIPOPOLYSACCHARIDE; PROTEIN P22; PROTEIN P47; PROTEIN P67; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; MICROGLIA; POLYMERASE CHAIN REACTION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; UPREGULATION;

ANIMALS; CELL LINE; ENZYME ACTIVATION; ENZYME INHIBITORS; HYDROGEN PEROXIDE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; MICROSCOPY, CONFOCAL; NADPH OXIDASE; POLYMERASE CHAIN REACTION; REACTIVE OXYGEN SPECIES;

EID: 84862871522     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0415-1     Document Type: Article

References (32)

1. Anrather, J., Racchumi, G., and Iadecola, C., NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox. J. Biol. Chem., 281, 5657-5667 (2006).
2. Babior, B. M., NADPH oxidase: an update. Blood, 93, 1464-1476 (1999).
3. Bedard, K. and Krause, K. H., The NOX family of ROSgenerating NADPH oxidases: physiology and pathophysiology. Physiol. Rev., 87, 245-313 (2007).
4. Brown, G. E., Stewart, M. Q., Bissonnette, S. A., Elia, A. E., Wilker, E., and Yaffe, M. B., Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase. J. Biol. Chem., 279, 27059-27068 (2004).
5. Coyle, J. T. and Puttfarcken, P., Oxidative stress, glutamate, and neurodegenerative disorders. Science, 262, 689-695 (1993).
6. Crisostomo, P. R., Wang, Y., Markel, T. A., Wang, M., Lahm, T., and Meldrum, D. R., Human mesenchymal stem cells stimulated by TNF-alpha, LPS, or hypoxia produce growth factors by an NF kappa B-but not JNK-dependent mechanism. Am. J. Physiol. Cell Physiol., 294, C675-C682 (2008).
7. Davis, R. J., Signal transduction by the JNK group of MAP kinases. Cell, 103, 239-252 (2000).
8. El-Remessy, A. B., Tang, Y., Zhu, G., Matragoon, S., Khalifa, Y., Liu, E. K., Liu, J. Y., Hanson, E., Mian, S., Fatteh, N., and Liou, G. I.. Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation. Mol. Vis., 14, 2190-2203 (2008).
9. Gauss, K. A., Nelson-Overton, L. K., Siemsen, D. W., Gao, Y., Deleo, F. R., and Quinn, M. T., Role of NF-kappaB in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor-alpha. J. Leukoc. Biol., 82, 729-741 (2007).
10. Huo, Y., Rangarajan, P., Ling, E. A., and Dheen, S. T., Dexamethasone inhibits the Nox-dependent ROS production via suppression of MKP-1-dependent MAPK pathways in activated microglia. BMC Neurosci., 12, 49 (2011).
11. Kacimi, R., Giffard, R. G., and Yenari, M. A., Endotoxin-activated microglia injure brain derived endothelial cells via NF-kappaB, JAK-STAT and JNK stress kinase pathways. J. Inflamm. (Lond.), 8, 7 (2011).
12. Karin, M., Liu, Z., and Zandi, E., AP-1 function and regulation. Curr. Opin. Cell Biol., 9, 240-246 (1997).
13. Kim, H. S., Ye, S. K., Cho, I. H., Jung, J. E., Kim, D. H., Choi, S., Kim, Y. S., Park, C. G., Kim, T. Y., Lee, J. W., and Chung, M. H., 8-hydroxydeoxyguanosine suppresses NO production and COX-2 activity via Rac1/STATs signaling in LPS-induced brain microglia. Free Radic. Biol. Med., 41, 1392-1403 (2006).
14. Kim, J. Y., Yu, S. J., Oh, H. J., Lee, J. Y., Kim, Y., and Sohn, J., Panaxydol induces apoptosis through an increased intracellular calcium level, activation of JNK and p38 MAPK and NADPH oxidase-dependent generation of reactive oxygen species. Apoptosis, 16, 347-358 (2011).
15. Kuwano, Y., Tominaga, K., Kawahara, T., Sasaki, H., Takeo, K., Nishida, K., Masuda, K., Kawai, T., Teshima-Kondo, S., and Rokutan, K., Tumor necrosis factor alpha activates transcription of the NADPH oxidase organizer 1 (NOXO1) gene and upregulates superoxide production in colon epithelial cells. Free Radic. Biol. Med., 45, 1642-1652 (2008).
16. Lavigne, M. C., Malech, H. L., Holland, S. M., and Leto, T. L., Genetic requirement of p47phox for superoxide production by murine microglia. FASEB J., 15, 285-287 (2001).
17. Manea, A., Manea, S. A., Gafencu, A. V., Raicu, M., and Simionescu, M., AP-1-dependent transcriptional regulation of NADPH oxidase in human aortic smooth muscle cells: role of p22phox subunit. Arterioscler. Thromb. Vasc. Biol., 28, 878-885 (2008).
18. Marden, J. J., Zhang, Y., Oakley, F. D., Zhou, W., Luo, M., Jia, H. P., Mccray, P. B., Jr., Yaniv, M., Weitzman, J. B., and Engelhardt, J. F., JunD protects the liver from ischemia/ reperfusion injury by dampening AP-1 transcriptional activation. J. Biol. Chem., 283, 6687-6695 (2008).
19. Park, S., Ahn, J. Y., Lim, M. J., Kim, M. H., Yun, Y. S., Jeong, G., and Song, J. Y., Sustained expression of NADPH oxidase 4 by p38 MAPK-Akt signaling potentiates radiationinduced differentiation of lung fibroblasts. J. Mol. Med., 88, 807-816 (2010).
20. Parvathenani, L. K., Tertyshnikova, S., Greco, C. R., Roberts, S. B., Robertson, B., and Posmantur, R., P2X7 mediates superoxide production in primary microglia and is upregulated in a transgenic mouse model of Alzheimer's disease. J. Biol. Chem., 278, 13309-13317 (2003).
21. Quiroga, A. D., De Lujan Alvarez, M., Parody, J. P., Ronco, M. T., Carnovale, C. E., and Carrillo, M. C., Interferonalpha2b (IFN-alpha2b)-induced apoptosis is mediated by p38 MAPK in hepatocytes from rat preneoplastic liver via activation of NADPH oxidase. Growth Factors, 27, 214-227 (2009).
22. Reynolds, A., Laurie, C., Mosley, R. L., and Gendelman, H. E., Oxidative stress and the pathogenesis of neurodegenerative disorders. Int. Rev. Neurobiol., 82, 297-325 (2007).
23. Sorce, S. and Krause, K. H., NOX enzymes in the central nervous system: from signaling to disease. Antioxid. Redox Signal., 11, 2481-2504 (2009).
24. Sun, H. N., Kim, S. U., Lee, M. S., Kim, S. K., Kim, J. M., Yim, M., Yu, D. Y., and Lee, D. S., Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent activation of phosphoinositide 3-kinase and p38 mitogenactivated protein kinase signal pathways is required for lipopolysaccharide-induced microglial phagocytosis. Biol. Pharm. Bull., 31, 1711-1715 (2008).
25. Sun, H. N., Kim, S. U., Huang, S. M., Kim, J. M., Park, Y. H., Kim, S. H., Yang, H. Y., Chung, K. J., Lee, T. H., Choi, H. S., Min, J. S., Park, M. K., Kim, S. K., Lee, S. R., Chang, K. T., Lee, S. H., Yu, D. Y., and Lee, D. S., Microglial peroxiredoxin V acts as an inducible anti-inflammatory antioxidant through cooperation with redox signaling cascades. J. Neurochem., 114, 39-50 (2010).
26. Svensson, C., Part, K., Kunnis-Beres, K., Kaldmae, M., Fernaeus, S. Z., and Land, T., Pro-survival effects of JNK and p38 MAPK pathways in LPS-induced activation of BV-2 cells. Biochem. Biophys. Res. Commun., 406, 488-492 (2011).
27. Torres, M. and Forman, H. J., Redox signaling and the MAP kinase pathways. Biofactors, 17, 287-296 (2003).
28. Wang, X. J., Zhang, S., Yan, Z. Q., Zhao, Y. X., Zhou, H. Y., Wang, Y., Lu, G. Q., and Zhang, J. D., Impaired CD200-CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: roles of aging, superoxide, NADPH oxidase, and p38 MAPK. Free Radic. Biol. Med., 50, 1094-1106 (2011).
29. Watters, J. J., Sommer, J. A., Pfeiffer, Z. A., Prabhu, U., Guerra, A. N., and Bertics, P. J., A differential role for the mitogen-activated protein kinases in lipopolysaccharide signaling: the MEK/ERK pathway is not essential for nitric oxide and interleukin 1beta production. J. Biol. Chem., 277, 9077-9087 (2002).
30. Yamamori, T., Inanami, O., Nagahata, H., Cui, Y., and Kuwabara, M., Roles of p38 MAPK, PKC and PI3-K in the signaling pathways of NADPH oxidase activation and phagocytosis in bovine polymorphonuclear leukocytes. FEBS Lett., 467, 253-258 (2000).
31. Yoo, B. K., Choi, J. W., Shin, C. Y., Jeon, S. J., Park, S. J., Cheong, J. H., Han, S. Y., Ryu, J. R., Song, M. R., and Ko, K. H., Activation of p38 MAPK induced peroxynitrite generation in LPS plus IFN-gamma-stimulated rat primary astrocytes via activation of iNOS and NADPH oxidase. Neurochem. Int., 52, 1188-1197 (2008).
32. Zhang, L., Wu, C., Zhao, S., Yuan, D., Lian, G., Wang, X., Wang, L., and Yang, J., Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROSrelated MAPK/NF-kappaB signaling pathways in N9 microglia induced by lipopolysaccharide. Int. Immunopharmacol., 10, 331-338 (2010).