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Volumn 33, Issue 2, 2012, Pages 191-206

Microglia in the developing brain: A potential target with lifetime effects

Author keywords

Brain macrophages; Developmental neurotoxicity; Microglia; Ontogeny; Pruning

Indexed keywords

ANGIOGENESIS; BRAIN DEVELOPMENT; BRAIN INFECTION; BRAIN INJURY; CELL AGING; CELL PROLIFERATION; CELLULAR DISTRIBUTION; EARLY LIFE STRESS; ENCEPHALITIS; EXCITOTOXICITY; HUMAN; INFECTION SENSITIVITY; LIFESPAN; MACROPHAGE FUNCTION; MICROGLIA; MOLECULAR STABILITY; MYELINATION; NERVE CELL DIFFERENTIATION; NERVE CELL NECROSIS; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; NUCLEAR REPROGRAMMING; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SYNAPTIC TRANSMISSION; SYNAPTOGENESIS;

EID: 84857008054     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2012.01.012     Document Type: Review
Times cited : (200)

References (205)
  • 1
    • 0347364630 scopus 로고    scopus 로고
    • Migration and differentiation of neural precursor cells can be directed by microglia
    • Aarum J., Sandberg K., Haeberlein S.L., Persson M.A. Migration and differentiation of neural precursor cells can be directed by microglia. Proc Natl Acad Sci USA 2003, 100:15983-15989.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15983-15989
    • Aarum, J.1    Sandberg, K.2    Haeberlein, S.L.3    Persson, M.A.4
  • 2
    • 33947363967 scopus 로고    scopus 로고
    • The fibrin-derived γ377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease
    • Adams R.A., Bauer J., Flick M.J., Sikorski S.L., Nuriel T., Lassmann H., et al. The fibrin-derived γ377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. J Exp Med 2007, 204:571-582.
    • (2007) J Exp Med , vol.204 , pp. 571-582
    • Adams, R.A.1    Bauer, J.2    Flick, M.J.3    Sikorski, S.L.4    Nuriel, T.5    Lassmann, H.6
  • 3
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • Ajami B., Bennett J.L., Krieger C., Tetziaff W., Rossi F.M. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci 2007, 10:1538-1543.
    • (2007) Nat Neurosci , vol.10 , pp. 1538-1543
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    Tetziaff, W.4    Rossi, F.M.5
  • 6
    • 0013991569 scopus 로고
    • The histiocyte in human foetal tissues: its morphology, cytochemistry, origin, function and fate
    • Andersen H., Matthiessen M.E. The histiocyte in human foetal tissues: its morphology, cytochemistry, origin, function and fate. Z Zellforsch 1966, 72:193-212.
    • (1966) Z Zellforsch , vol.72 , pp. 193-212
    • Andersen, H.1    Matthiessen, M.E.2
  • 7
    • 0026643572 scopus 로고
    • Intracebral injection of proinflammatory cytokines or leucocyte chemotaxins induces minimal myelomonocytic cell recruitment to the parenchyma of the CNS
    • Andersson P.B., Perry V.H., Gordon S. Intracebral injection of proinflammatory cytokines or leucocyte chemotaxins induces minimal myelomonocytic cell recruitment to the parenchyma of the CNS. J Exp Med 1992, 176:255-259.
    • (1992) J Exp Med , vol.176 , pp. 255-259
    • Andersson, P.B.1    Perry, V.H.2    Gordon, S.3
  • 8
    • 0032517803 scopus 로고    scopus 로고
    • Macrophages/microglial cells in human central nervous system during development: an immunohistochemical study
    • Andjelkovic A.V., Nikolic B., Pachter J.S., Zecevic N. Macrophages/microglial cells in human central nervous system during development: an immunohistochemical study. Brain Res 1998, 814:13-25.
    • (1998) Brain Res , vol.814 , pp. 13-25
    • Andjelkovic, A.V.1    Nikolic, B.2    Pachter, J.S.3    Zecevic, N.4
  • 9
    • 78751689107 scopus 로고    scopus 로고
    • Endogenous microglia regulate development of embryonic cortical precursor cells
    • Antony J.M., Paquin A., Nutt S.L., Kaplan D.R., Miller F. Endogenous microglia regulate development of embryonic cortical precursor cells. J Neurosci Res 2011, 89:286-298.
    • (2011) J Neurosci Res , vol.89 , pp. 286-298
    • Antony, J.M.1    Paquin, A.2    Nutt, S.L.3    Kaplan, D.R.4    Miller, F.5
  • 11
    • 0002715915 scopus 로고
    • Das reliculo-endotheliale system
    • Aschoff L. Das reliculo-endotheliale system. Ergeb Inn Med Kinderheilkd 1924, 26:1-118.
    • (1924) Ergeb Inn Med Kinderheilkd , vol.26 , pp. 1-118
    • Aschoff, L.1
  • 12
    • 70349484628 scopus 로고    scopus 로고
    • Inflammation in rat pups subjected to short hyperthermic seizures enhances brain long-term excitability
    • Auvin S., Porta N., Nehlig A., Lecointe C., Vallee L., Bordet R. Inflammation in rat pups subjected to short hyperthermic seizures enhances brain long-term excitability. Epilepsy Res 2009, 86:124-130.
    • (2009) Epilepsy Res , vol.86 , pp. 124-130
    • Auvin, S.1    Porta, N.2    Nehlig, A.3    Lecointe, C.4    Vallee, L.5    Bordet, R.6
  • 15
    • 0030250932 scopus 로고    scopus 로고
    • Comparison of phenotypic and functional properties of immediately ex vivo and cultured human adult microglia
    • Becher B., Antel J.P. Comparison of phenotypic and functional properties of immediately ex vivo and cultured human adult microglia. Glia 1996, 18:1-10.
    • (1996) Glia , vol.18 , pp. 1-10
    • Becher, B.1    Antel, J.P.2
  • 16
    • 0033824640 scopus 로고    scopus 로고
    • Phagocytosis of neuronal or glial debris by microglial cells: upregulation of MHC class II expression and multinuclear giant cell formation in vitro
    • Beyer M., Gimsa U., Eyupoglu I.Y., Hailer N.P., Nitsch R. Phagocytosis of neuronal or glial debris by microglial cells: upregulation of MHC class II expression and multinuclear giant cell formation in vitro. Glia 2000, 31:262-266.
    • (2000) Glia , vol.31 , pp. 262-266
    • Beyer, M.1    Gimsa, U.2    Eyupoglu, I.Y.3    Hailer, N.P.4    Nitsch, R.5
  • 18
    • 77953543114 scopus 로고    scopus 로고
    • Early-life infection is a vulnerability factor for aging related glial alterations and cognitive decline
    • Bilbo S.D. Early-life infection is a vulnerability factor for aging related glial alterations and cognitive decline. Neurobiol Learn Mem 2010, 94:57-64.
    • (2010) Neurobiol Learn Mem , vol.94 , pp. 57-64
    • Bilbo, S.D.1
  • 19
    • 77649139342 scopus 로고    scopus 로고
    • Early-life programming of later-life brain and behavior: a critical role for the immune system
    • Bilbo S.D., Schwarz J.M. Early-life programming of later-life brain and behavior: a critical role for the immune system. Front Behav Neurosci 2009, 3:14.
    • (2009) Front Behav Neurosci , vol.3 , pp. 14
    • Bilbo, S.D.1    Schwarz, J.M.2
  • 20
    • 24344478174 scopus 로고    scopus 로고
    • Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition
    • Bilbo S.D., Biedenkapp J.C., Der-Avakian A., Watkins L.R., Rudy J.W., Maier S.F. Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition. J Neurosci 2005, 25:8000-8009.
    • (2005) J Neurosci , vol.25 , pp. 8000-8009
    • Bilbo, S.D.1    Biedenkapp, J.C.2    Der-Avakian, A.3    Watkins, L.R.4    Rudy, J.W.5    Maier, S.F.6
  • 21
    • 33244494436 scopus 로고    scopus 로고
    • A behavioural characterization of neonatal infection-facilitated memory impairment in adult rats
    • Bilbo S.D., Rudy J.W., Watkins L.R., Maier S.F. A behavioural characterization of neonatal infection-facilitated memory impairment in adult rats. Behav Brain Res 2006, 169:39-47.
    • (2006) Behav Brain Res , vol.169 , pp. 39-47
    • Bilbo, S.D.1    Rudy, J.W.2    Watkins, L.R.3    Maier, S.F.4
  • 23
    • 84858008384 scopus 로고    scopus 로고
    • Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain
    • Bland S.T., Beckley J.T., Young S., Tsang V., Watkins L.R., Maier S.F., et al. Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain. Brain Behav Immun 2010, 22:451-455.
    • (2010) Brain Behav Immun , vol.22 , pp. 451-455
    • Bland, S.T.1    Beckley, J.T.2    Young, S.3    Tsang, V.4    Watkins, L.R.5    Maier, S.F.6
  • 24
    • 77954218028 scopus 로고    scopus 로고
    • Effects of prenatal infection on brain development and behavior: a review of findings from animal models
    • Boksa P. Effects of prenatal infection on brain development and behavior: a review of findings from animal models. Brain Behav Immun 2010, 24:881-897.
    • (2010) Brain Behav Immun , vol.24 , pp. 881-897
    • Boksa, P.1
  • 26
    • 79952123263 scopus 로고    scopus 로고
    • Maternal infection and schizophrenia: implications for prevention
    • Brown A.S., Patterson P.H. Maternal infection and schizophrenia: implications for prevention. Schizophr Bull 2011, 37:284-290.
    • (2011) Schizophr Bull , vol.37 , pp. 284-290
    • Brown, A.S.1    Patterson, P.H.2
  • 27
    • 0031661172 scopus 로고    scopus 로고
    • Cellular localization and temporal elevation of TNF, IL-1, and TGFβ1 mRNA in hippocampal injury response induced by trimethyltin
    • Bruccoleri A., Brown H.W., Harry G.J. Cellular localization and temporal elevation of TNF, IL-1, and TGFβ1 mRNA in hippocampal injury response induced by trimethyltin. J Neurochem 1998, 71:1577-1587.
    • (1998) J Neurochem , vol.71 , pp. 1577-1587
    • Bruccoleri, A.1    Brown, H.W.2    Harry, G.J.3
  • 28
    • 0037728798 scopus 로고    scopus 로고
    • Differential roles of tumor necrosis factor-alpha and interleukin-1 beta in lipopolysaccharide-induced brain injury in the neonatal rat
    • Cai Z., Pang Y., Lin S., Rhodes P.G. Differential roles of tumor necrosis factor-alpha and interleukin-1 beta in lipopolysaccharide-induced brain injury in the neonatal rat. Brain Res 2003, 975:37-47.
    • (2003) Brain Res , vol.975 , pp. 37-47
    • Cai, Z.1    Pang, Y.2    Lin, S.3    Rhodes, P.G.4
  • 29
    • 0001619989 scopus 로고
    • Contribucion al conocimiento de la meuroglia del cerebro humano
    • Cajal R.Y. Contribucion al conocimiento de la meuroglia del cerebro humano. Trab Lab Invest Biol 1913, 11:254.
    • (1913) Trab Lab Invest Biol , vol.11 , pp. 254
    • Cajal, R.Y.1
  • 30
    • 0031985336 scopus 로고    scopus 로고
    • Mature microglia resemble immature antigen-presenting cells
    • Carson M.J., Reilly C.R., Sutcliff J.G., Lo D. Mature microglia resemble immature antigen-presenting cells. Glia 1998, 22:72-85.
    • (1998) Glia , vol.22 , pp. 72-85
    • Carson, M.J.1    Reilly, C.R.2    Sutcliff, J.G.3    Lo, D.4
  • 32
    • 0028342433 scopus 로고
    • Brain macrophages stimulate neurite growth and regeneration by secreting thrombospondin
    • Chamak B., Morandi V., Mallat M. Brain macrophages stimulate neurite growth and regeneration by secreting thrombospondin. J Neurosci Res 1994, 38:221-233.
    • (1994) J Neurosci Res , vol.38 , pp. 221-233
    • Chamak, B.1    Morandi, V.2    Mallat, M.3
  • 33
    • 33846571886 scopus 로고    scopus 로고
    • The origin and cell lineage of microglia - new concepts
    • Chan W.Y., Kohsaka S., Razaie P. The origin and cell lineage of microglia - new concepts. Brain Res Rev 2007, 53:344-354.
    • (2007) Brain Res Rev , vol.53 , pp. 344-354
    • Chan, W.Y.1    Kohsaka, S.2    Razaie, P.3
  • 34
    • 78650677309 scopus 로고    scopus 로고
    • Maternal separation affects the number, proliferation and apoptosis of glia cells in the substantia nigra and ventral tegmental area of juvenile rats
    • Chocyk A., Dudys D., Przyborowska A., Majcher I., Mackowiak M., Wedzony K. Maternal separation affects the number, proliferation and apoptosis of glia cells in the substantia nigra and ventral tegmental area of juvenile rats. Neurosci 2011, 173:1-18.
    • (2011) Neurosci , vol.173 , pp. 1-18
    • Chocyk, A.1    Dudys, D.2    Przyborowska, A.3    Majcher, I.4    Mackowiak, M.5    Wedzony, K.6
  • 35
    • 0019414892 scopus 로고
    • Haematogenous cells in the central nervous system of developing human embryos and fetuses
    • Choi B.H. Haematogenous cells in the central nervous system of developing human embryos and fetuses. J Comp Neurol 1981, 196:683-694.
    • (1981) J Comp Neurol , vol.196 , pp. 683-694
    • Choi, B.H.1
  • 37
    • 44649201117 scopus 로고    scopus 로고
    • Activity-dependent regulation of synaptic AMPA receptor composition and abundance by beta3 integrins
    • Cingolani L.A., Thalhammer A., Yu L.M., Catalano M., Ramos T., Colicos M.A., et al. Activity-dependent regulation of synaptic AMPA receptor composition and abundance by beta3 integrins. Neuron 2008, 58:749-762.
    • (2008) Neuron , vol.58 , pp. 749-762
    • Cingolani, L.A.1    Thalhammer, A.2    Yu, L.M.3    Catalano, M.4    Ramos, T.5    Colicos, M.A.6
  • 39
    • 0031690332 scopus 로고    scopus 로고
    • The origin and differentiation of microglial cells during development
    • Cuadros M.A., Navascues J. The origin and differentiation of microglial cells during development. Prog Neurobiol 1998, 56:173-189.
    • (1998) Prog Neurobiol , vol.56 , pp. 173-189
    • Cuadros, M.A.1    Navascues, J.2
  • 42
    • 45549098351 scopus 로고    scopus 로고
    • Molecular mechanisms of preconditioning
    • Das M., Das D.K. Molecular mechanisms of preconditioning. IUBMB Life 2008, 60:199-203.
    • (2008) IUBMB Life , vol.60 , pp. 199-203
    • Das, M.1    Das, D.K.2
  • 44
    • 33750125650 scopus 로고    scopus 로고
    • Bone marrow CD34+/B220+ progenitors target the inflamed brain and display in vitro differentiation potential toward microglia
    • Davoust N., Vuaillat C., Cavillon G., Domenget C., Hatterer E., Bernard A., et al. Bone marrow CD34+/B220+ progenitors target the inflamed brain and display in vitro differentiation potential toward microglia. FASEB J 2006, 20:2081-2092.
    • (2006) FASEB J , vol.20 , pp. 2081-2092
    • Davoust, N.1    Vuaillat, C.2    Cavillon, G.3    Domenget, C.4    Hatterer, E.5    Bernard, A.6
  • 46
    • 54049130467 scopus 로고    scopus 로고
    • Progress in periventricular leukomalacia
    • Deng W., Pleasure J., Pleasure D. Progress in periventricular leukomalacia. Arch Neurol 2008, 65:1291-1295.
    • (2008) Arch Neurol , vol.65 , pp. 1291-1295
    • Deng, W.1    Pleasure, J.2    Pleasure, D.3
  • 47
    • 0030729012 scopus 로고    scopus 로고
    • Direct ex vivo flow cytometric analysis of human microglial cell CD14 expression: examination of central nervous system biopsy specimens from HIV-seropositive patients with other neurological diseases
    • Dick A.D., Pell M., Brew B.J., Foulcher E., Sedgwick J.D. Direct ex vivo flow cytometric analysis of human microglial cell CD14 expression: examination of central nervous system biopsy specimens from HIV-seropositive patients with other neurological diseases. AIDS 1997, 11:1699-1708.
    • (1997) AIDS , vol.11 , pp. 1699-1708
    • Dick, A.D.1    Pell, M.2    Brew, B.J.3    Foulcher, E.4    Sedgwick, J.D.5
  • 48
    • 78650236263 scopus 로고    scopus 로고
    • Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions
    • Drouin-Ouellet J., Brownell A.L., Saint-Pierre M., Fasano C., Emond V., Trudeau L.E., et al. Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions. Glia 2011, 59:188-199.
    • (2011) Glia , vol.59 , pp. 188-199
    • Drouin-Ouellet, J.1    Brownell, A.L.2    Saint-Pierre, M.3    Fasano, C.4    Emond, V.5    Trudeau, L.E.6
  • 49
    • 70349823133 scopus 로고    scopus 로고
    • The promise of epidemiologic studies: neuroimmune mechanisms in the etiologies of brain disorders
    • Ellman L.M., Susser E.S. The promise of epidemiologic studies: neuroimmune mechanisms in the etiologies of brain disorders. Neuron 2009, 64:25-27.
    • (2009) Neuron , vol.64 , pp. 25-27
    • Ellman, L.M.1    Susser, E.S.2
  • 50
    • 80055051144 scopus 로고    scopus 로고
    • Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits
    • Erblich B., Zhu L., Etgen A.M., Dobrenis K., Pollard J.W. Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits. PLoS One 2011, 6:e26317.
    • (2011) PLoS One , vol.6
    • Erblich, B.1    Zhu, L.2    Etgen, A.M.3    Dobrenis, K.4    Pollard, J.W.5
  • 51
    • 0026022020 scopus 로고
    • Macrophages, microglia cells, and HLA-DR antigens in fetal and infant brain
    • Esiri M.M., Al Izzi M.S., Reading M.C. Macrophages, microglia cells, and HLA-DR antigens in fetal and infant brain. J Clin Pathol 1991, 44:102-106.
    • (1991) J Clin Pathol , vol.44 , pp. 102-106
    • Esiri, M.M.1    Al Izzi, M.S.2    Reading, M.C.3
  • 52
    • 0025696092 scopus 로고
    • Naturally occurring cell death in the cerebral cortex of the rat and removal of dead cells by transitory phagocytes
    • Ferrer I., Bennet E., Soriano E.T., del Rio T., Fonseca M. Naturally occurring cell death in the cerebral cortex of the rat and removal of dead cells by transitory phagocytes. Neuroscience 1990, 39:451-458.
    • (1990) Neuroscience , vol.39 , pp. 451-458
    • Ferrer, I.1    Bennet, E.2    Soriano, E.T.3    del Rio, T.4    Fonseca, M.5
  • 54
    • 0034094052 scopus 로고    scopus 로고
    • Microglial activation in the developing rat olfactory bulb
    • Fiske B.K., Brunjes P.C. Microglial activation in the developing rat olfactory bulb. Neuroscience 2000, 96:807-815.
    • (2000) Neuroscience , vol.96 , pp. 807-815
    • Fiske, B.K.1    Brunjes, P.C.2
  • 55
    • 0347285467 scopus 로고    scopus 로고
    • Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes
    • Flanary B.E., Streit W.J. Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes. Glia 2004, 45:75-88.
    • (2004) Glia , vol.45 , pp. 75-88
    • Flanary, B.E.1    Streit, W.J.2
  • 56
  • 57
    • 0035869637 scopus 로고    scopus 로고
    • Regulation of microglial development: a novel role for thyroid hormone
    • Flavia R., Lima S., Gervais A., Colin C., Izembart M., Neto V.M., et al. Regulation of microglial development: a novel role for thyroid hormone. J Neurosci 2001, 21:2028-2038.
    • (2001) J Neurosci , vol.21 , pp. 2028-2038
    • Flavia, R.1    Lima, S.2    Gervais, A.3    Colin, C.4    Izembart, M.5    Neto, V.M.6
  • 58
    • 79960744467 scopus 로고    scopus 로고
    • Microglia demonstrate age-dependent interaction with amyloid-β fibrils
    • Floden A.M., Combs C.K. Microglia demonstrate age-dependent interaction with amyloid-β fibrils. J Alzheimers Dis 2011, 25(2):279.
    • (2011) J Alzheimers Dis , vol.25 , Issue.2 , pp. 279
    • Floden, A.M.1    Combs, C.K.2
  • 59
    • 0035476293 scopus 로고    scopus 로고
    • Transformation of donor-derived bone marrow precursors into host microglia during autoimmune CNS inflammation and during the retrograde response to axotomy
    • Flugel A., Bradl M., Kreutzberg G.W., Graeber M.B. Transformation of donor-derived bone marrow precursors into host microglia during autoimmune CNS inflammation and during the retrograde response to axotomy. J Neurosci Res 2001, 66:74-82.
    • (2001) J Neurosci Res , vol.66 , pp. 74-82
    • Flugel, A.1    Bradl, M.2    Kreutzberg, G.W.3    Graeber, M.B.4
  • 61
    • 0024437592 scopus 로고
    • Histochemical study of the differentiation of microglial cells in the developing human cerebral hemispheres
    • Fujimoto E., Miki A., Mizoguti H. Histochemical study of the differentiation of microglial cells in the developing human cerebral hemispheres. J Anat 1989, 166:253-264.
    • (1989) J Anat , vol.166 , pp. 253-264
    • Fujimoto, E.1    Miki, A.2    Mizoguti, H.3
  • 62
    • 79960278270 scopus 로고    scopus 로고
    • Voluntary exercise protects hippocampal neurons from trimethyltin injury: possible role of interleukin-6 to modulate tumor necrosis factor receptor-mediated neurotoxicity
    • Funk J.A., Gohlke J., Kraft A.D., McPherson C.A., Collins J.B., Harry G.J. Voluntary exercise protects hippocampal neurons from trimethyltin injury: possible role of interleukin-6 to modulate tumor necrosis factor receptor-mediated neurotoxicity. Brain Behav Immun 2011, 25:1063-1077.
    • (2011) Brain Behav Immun , vol.25 , pp. 1063-1077
    • Funk, J.A.1    Gohlke, J.2    Kraft, A.D.3    McPherson, C.A.4    Collins, J.B.5    Harry, G.J.6
  • 64
    • 33747463996 scopus 로고    scopus 로고
    • Microglia biology in health and disease
    • Garden G.C., Moller T. Microglia biology in health and disease. J Neuroimmune Pharmacol 2006, 1:127-137.
    • (2006) J Neuroimmune Pharmacol , vol.1 , pp. 127-137
    • Garden, G.C.1    Moller, T.2
  • 65
    • 0036182751 scopus 로고    scopus 로고
    • Roles of the complement system in human neurode-generative disorders: pro-inflammatory and tissue remodeling activities
    • Gasque P., Neal J.W., Singhrao S.K., McGreal E.P., Dean Y.D., Van B.J., et al. Roles of the complement system in human neurode-generative disorders: pro-inflammatory and tissue remodeling activities. Mol Neurobiol 2002, 25:1-17.
    • (2002) Mol Neurobiol , vol.25 , pp. 1-17
    • Gasque, P.1    Neal, J.W.2    Singhrao, S.K.3    McGreal, E.P.4    Dean, Y.D.5    Van, B.J.6
  • 66
    • 78149360132 scopus 로고    scopus 로고
    • Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    • Ginhoux F., Greter M., Leboeuf M., Nandi S., See P., Gokhan S., et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 2010, 330:841-845.
    • (2010) Science , vol.330 , pp. 841-845
    • Ginhoux, F.1    Greter, M.2    Leboeuf, M.3    Nandi, S.4    See, P.5    Gokhan, S.6
  • 67
  • 68
    • 0028881820 scopus 로고
    • Cell surface morphology identifies microglia as a distinct class of mononuclear phagocyte
    • Giulian D., Li J., Bartel S., Broker J., Li X., Kirkpatrick J.B. Cell surface morphology identifies microglia as a distinct class of mononuclear phagocyte. J Neurosci 1995, 15:7712-7726.
    • (1995) J Neurosci , vol.15 , pp. 7712-7726
    • Giulian, D.1    Li, J.2    Bartel, S.3    Broker, J.4    Li, X.5    Kirkpatrick, J.B.6
  • 69
    • 7044231658 scopus 로고    scopus 로고
    • Umbilical cord plasma interleukin-6 concentrations in preterm infants and risk of neonatal morbidity
    • Goepfert A.R., Andrews W.W., Carlo W., Ramsey P.S., Cliver S.P., Goldenberg R.L., et al. Umbilical cord plasma interleukin-6 concentrations in preterm infants and risk of neonatal morbidity. Am J Obstet Gynecol 2004, 191:1375-1381.
    • (2004) Am J Obstet Gynecol , vol.191 , pp. 1375-1381
    • Goepfert, A.R.1    Andrews, W.W.2    Carlo, W.3    Ramsey, P.S.4    Cliver, S.P.5    Goldenberg, R.L.6
  • 70
    • 77953012930 scopus 로고    scopus 로고
    • Prenatal stress alters microglial development and distribution in postnatal rat brain
    • Gomez-Gonzalez B., Escobar A. Prenatal stress alters microglial development and distribution in postnatal rat brain. Acta Neuropathol 2010, 119:303-315.
    • (2010) Acta Neuropathol , vol.119 , pp. 303-315
    • Gomez-Gonzalez, B.1    Escobar, A.2
  • 73
    • 0029840954 scopus 로고    scopus 로고
    • Intracerebral NMDA injection stimulates production of interleukin-1 beta in perinatal rat brain
    • Hagan P., Poole S., Bristow A.F., Tilders F., Silverstein F.S. Intracerebral NMDA injection stimulates production of interleukin-1 beta in perinatal rat brain. J Neurochem 1996, 67:2215-2218.
    • (1996) J Neurochem , vol.67 , pp. 2215-2218
    • Hagan, P.1    Poole, S.2    Bristow, A.F.3    Tilders, F.4    Silverstein, F.S.5
  • 74
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: active sensor and versatile effector cells in the normal and pathologic brain
    • Hanisch U.K., Kettenmann H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 2007, 11:1387-1394.
    • (2007) Nat Neurosci , vol.11 , pp. 1387-1394
    • Hanisch, U.K.1    Kettenmann, H.2
  • 75
    • 55049136520 scopus 로고    scopus 로고
    • Neuroinflammation and microglia: considerations and approaches for neurotixicity assessment
    • Harry G.J., Kraft A.D. Neuroinflammation and microglia: considerations and approaches for neurotixicity assessment. Expert Opin Drug Metab Toxicol 2008, 4:1266-1277.
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , pp. 1266-1277
    • Harry, G.J.1    Kraft, A.D.2
  • 76
    • 33747394460 scopus 로고    scopus 로고
    • Maternal infection and white matter toxicity
    • Harry G.J., Lawler C., Brunssen S.H. Maternal infection and white matter toxicity. Neurotoxicology 2006, 27:658-670.
    • (2006) Neurotoxicology , vol.27 , pp. 658-670
    • Harry, G.J.1    Lawler, C.2    Brunssen, S.H.3
  • 77
    • 0032006643 scopus 로고    scopus 로고
    • Vitamin E induces ramification and downregulation of adhesion molecules in cultured microglial cells
    • Heppner F.L., Roth K., Nitsch R., Hailer N.P. Vitamin E induces ramification and downregulation of adhesion molecules in cultured microglial cells. Glia 1998, 22:180-188.
    • (1998) Glia , vol.22 , pp. 180-188
    • Heppner, F.L.1    Roth, K.2    Nitsch, R.3    Hailer, N.P.4
  • 79
    • 0023949553 scopus 로고
    • Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
    • Hickey W.F., Kimura H. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 1988, 239:290-292.
    • (1988) Science , vol.239 , pp. 290-292
    • Hickey, W.F.1    Kimura, H.2
  • 81
    • 4344710139 scopus 로고    scopus 로고
    • Intrauterine infection/inflammation during pregnancy and offspring brain damages: possible mechanisms involved
    • Huleihel M., Golan H., Hallak M. Intrauterine infection/inflammation during pregnancy and offspring brain damages: possible mechanisms involved. Reprod Biol Endocrinol 2004, 2:17.
    • (2004) Reprod Biol Endocrinol , vol.2 , pp. 17
    • Huleihel, M.1    Golan, H.2    Hallak, M.3
  • 83
    • 0020536689 scopus 로고
    • Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers
    • Hume D.A., Perry V.H., Gordon S. Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers. J Cell Biol 1983, 97:253-257.
    • (1983) J Cell Biol , vol.97 , pp. 253-257
    • Hume, D.A.1    Perry, V.H.2    Gordon, S.3
  • 84
    • 71749083143 scopus 로고    scopus 로고
    • Activation of microglia by neuronal activity: results from a new in vitro paradigm based on neuronal-silicon interfacing technology
    • Hung J., Chansard M., Ousman S.S., Nguyen M.D., Colicos M.A. Activation of microglia by neuronal activity: results from a new in vitro paradigm based on neuronal-silicon interfacing technology. Brain Behav Immun 2010, 24:31-40.
    • (2010) Brain Behav Immun , vol.24 , pp. 31-40
    • Hung, J.1    Chansard, M.2    Ousman, S.S.3    Nguyen, M.D.4    Colicos, M.A.5
  • 85
    • 0029555385 scopus 로고
    • Griffonia simplicifolia II lectin labels a population of radial glial cells in the embryonic rat brain
    • Hurley S.D., Streit W.J. Griffonia simplicifolia II lectin labels a population of radial glial cells in the embryonic rat brain. Dev Neurosci 1995, 17:324-334.
    • (1995) Dev Neurosci , vol.17 , pp. 324-334
    • Hurley, S.D.1    Streit, W.J.2
  • 86
    • 0025335694 scopus 로고
    • Localization of morphologically distinct microglial populations in the developing human fetal brain: implications for ontogeny
    • Hutchins K.D., Dickson D.W., Rashbaum W.K., Lyman W.D. Localization of morphologically distinct microglial populations in the developing human fetal brain: implications for ontogeny. Dev Brain Res 1990, 55:95-102.
    • (1990) Dev Brain Res , vol.55 , pp. 95-102
    • Hutchins, K.D.1    Dickson, D.W.2    Rashbaum, W.K.3    Lyman, W.D.4
  • 87
    • 0018096010 scopus 로고
    • Radioautographic investigation of gliogenesis in the corpus callosum of young rats. II. Origin of microglial cells
    • Imamoto K., Leblond C.P. Radioautographic investigation of gliogenesis in the corpus callosum of young rats. II. Origin of microglial cells. J Comp Neurol 1978, 180:139-164.
    • (1978) J Comp Neurol , vol.180 , pp. 139-164
    • Imamoto, K.1    Leblond, C.P.2
  • 88
    • 77954212567 scopus 로고    scopus 로고
    • Maternal immune activation alters nonspatial information processing in the hippocampus
    • Ito H.T., Smith S.E., Hsiao E., Patterson P.H. Maternal immune activation alters nonspatial information processing in the hippocampus. Brain Behav Immun 2010, 24:930-941.
    • (2010) Brain Behav Immun , vol.24 , pp. 930-941
    • Ito, H.T.1    Smith, S.E.2    Hsiao, E.3    Patterson, P.H.4
  • 89
    • 0030578454 scopus 로고    scopus 로고
    • Conditioned medium from activated microglia promotes cholinergic differentiation in the basal forebrain in vitro
    • Jonakait G.M., Luskin M.B., Wei R., Tian X.F., Ni L. Conditioned medium from activated microglia promotes cholinergic differentiation in the basal forebrain in vitro. Dev Biol 1996, 177:85-95.
    • (1996) Dev Biol , vol.177 , pp. 85-95
    • Jonakait, G.M.1    Luskin, M.B.2    Wei, R.3    Tian, X.F.4    Ni, L.5
  • 90
    • 0034105793 scopus 로고    scopus 로고
    • Macrophage cell-conditioned medium promotes cholinergic differentiation of undifferentiated progenitors and synergizes with nerve growth factor action in the developing basal forebrain
    • Jonakait G.M., Wen Y., Wan Y., Ni L. Macrophage cell-conditioned medium promotes cholinergic differentiation of undifferentiated progenitors and synergizes with nerve growth factor action in the developing basal forebrain. Exp Neurol 2000, 161:285-296.
    • (2000) Exp Neurol , vol.161 , pp. 285-296
    • Jonakait, G.M.1    Wen, Y.2    Wan, Y.3    Ni, L.4
  • 91
    • 79955732851 scopus 로고    scopus 로고
    • Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisomes proliferator-activated receptor-γ agonists
    • Kane C.J., Phelan K.D., Han L., Smith R.R., Xie J., Douglas J.C., et al. Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisomes proliferator-activated receptor-γ agonists. Brain Behav Immun 2011, 25:S137-S145.
    • (2011) Brain Behav Immun , vol.25
    • Kane, C.J.1    Phelan, K.D.2    Han, L.3    Smith, R.R.4    Xie, J.5    Douglas, J.C.6
  • 92
    • 0026331351 scopus 로고
    • A study of the transformation of amoeboid microglial cells into microglia labelled with the isolectin Griffonea simplicifolia in postnatal rats
    • Kaur C., Ling E.A. A study of the transformation of amoeboid microglial cells into microglia labelled with the isolectin Griffonea simplicifolia in postnatal rats. Acta Anat 1991, 142:118-125.
    • (1991) Acta Anat , vol.142 , pp. 118-125
    • Kaur, C.1    Ling, E.A.2
  • 93
    • 0001792648 scopus 로고
    • Genesis of microglia in the human brain
    • Kershman J. Genesis of microglia in the human brain. Arch Neurol Psychiat 1939, 41:24-50.
    • (1939) Arch Neurol Psychiat , vol.41 , pp. 24-50
    • Kershman, J.1
  • 94
    • 0027343512 scopus 로고
    • Electrophysiological behavior of microglia
    • Kettenmann H., Banati R., Walz W. Electrophysiological behavior of microglia. Glia 1993, 7:93-101.
    • (1993) Glia , vol.7 , pp. 93-101
    • Kettenmann, H.1    Banati, R.2    Walz, W.3
  • 95
    • 20944436901 scopus 로고    scopus 로고
    • The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2
    • Klunemann H.H., Ridha B.H., Magy L., Wherrett J.R., Hemelsoet D.M., Keen R.W., et al. The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2. Neurology 2005, 64:1502-1507.
    • (2005) Neurology , vol.64 , pp. 1502-1507
    • Klunemann, H.H.1    Ridha, B.H.2    Magy, L.3    Wherrett, J.R.4    Hemelsoet, D.M.5    Keen, R.W.6
  • 96
    • 48749100173 scopus 로고    scopus 로고
    • Influence of prenatal stress on behavioral, endocrine, and cytokine responses to adulthood bacterial endotoxin exposure
    • Kohman R.A., Tarr A.J., Day C.E., McLinden K.A., Boehm G.W. Influence of prenatal stress on behavioral, endocrine, and cytokine responses to adulthood bacterial endotoxin exposure. Behav Brain Res 2010, 193:257-268.
    • (2010) Behav Brain Res , vol.193 , pp. 257-268
    • Kohman, R.A.1    Tarr, A.J.2    Day, C.E.3    McLinden, K.A.4    Boehm, G.W.5
  • 97
    • 79960784323 scopus 로고    scopus 로고
    • Features of microglia and neuroinflammation relevant to environmental exposure and neurotoxicity
    • Kraft A.D., Harry G.J. Features of microglia and neuroinflammation relevant to environmental exposure and neurotoxicity. Int J Environ Public Health 2011, 8:2980-3011.
    • (2011) Int J Environ Public Health , vol.8 , pp. 2980-3011
    • Kraft, A.D.1    Harry, G.J.2
  • 98
    • 79960798306 scopus 로고    scopus 로고
    • Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons
    • [Epub]
    • Kraft A.D., Kaltenbach L.S., Lo D.C., Harry G.J. Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons. Neurobiol Aging 2011, [Epub].
    • (2011) Neurobiol Aging
    • Kraft, A.D.1    Kaltenbach, L.S.2    Lo, D.C.3    Harry, G.J.4
  • 99
    • 0036570325 scopus 로고    scopus 로고
    • Correlation between the sequential ingrowth of afferents and transient patterns of cortical lamination in preterm infants
    • Kostović I., Judas M. Correlation between the sequential ingrowth of afferents and transient patterns of cortical lamination in preterm infants. Anat Rec 2002, 267:1-6.
    • (2002) Anat Rec , vol.267 , pp. 1-6
    • Kostović, I.1    Judas, M.2
  • 100
    • 21944457972 scopus 로고    scopus 로고
    • Bone marrow-derived microglia contribute to the neuroinflammatory response and express iNOS in the MPTP mouse model of Parkinson's disease
    • Kokovay E., Cunningham L.A. Bone marrow-derived microglia contribute to the neuroinflammatory response and express iNOS in the MPTP mouse model of Parkinson's disease. Neurobiol Dis 2005, 19:471-478.
    • (2005) Neurobiol Dis , vol.19 , pp. 471-478
    • Kokovay, E.1    Cunningham, L.A.2
  • 102
    • 0027931095 scopus 로고
    • Characterization and transduction mechanisms of purinoceptors in activated rat mciroglia
    • Langosch J.M., Gebicke-Haerter P.J., Norenberg W., Illes P. Characterization and transduction mechanisms of purinoceptors in activated rat mciroglia. Br J Pharmacol 1994, 113:4403-4411.
    • (1994) Br J Pharmacol , vol.113 , pp. 4403-4411
    • Langosch, J.M.1    Gebicke-Haerter, P.J.2    Norenberg, W.3    Illes, P.4
  • 103
    • 0034503091 scopus 로고    scopus 로고
    • The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function
    • Lanier L.L., Bakker A.B. The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function. Immunol Today 2000, 21:611-614.
    • (2000) Immunol Today , vol.21 , pp. 611-614
    • Lanier, L.L.1    Bakker, A.B.2
  • 104
    • 0026073369 scopus 로고
    • Microglial cells are a component of the perivascular glia limitans
    • Lassmann H., Zimprich F., Vass K., Hickey W.F. Microglial cells are a component of the perivascular glia limitans. J Neurosci Res 1991, 28:236-243.
    • (1991) J Neurosci Res , vol.28 , pp. 236-243
    • Lassmann, H.1    Zimprich, F.2    Vass, K.3    Hickey, W.F.4
  • 105
    • 0026552605 scopus 로고
    • Turnover of resident microglia in the normal adult mouse brain
    • Lawson L.J., Perry V.H., Gordon S. Turnover of resident microglia in the normal adult mouse brain. Neurosci 1992, 48:405-415.
    • (1992) Neurosci , vol.48 , pp. 405-415
    • Lawson, L.J.1    Perry, V.H.2    Gordon, S.3
  • 106
    • 0025220976 scopus 로고
    • Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
    • Lawson L.J., Perry V.H., Dri P., Gordon S. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neurosci 1990, 39:151-170.
    • (1990) Neurosci , vol.39 , pp. 151-170
    • Lawson, L.J.1    Perry, V.H.2    Dri, P.3    Gordon, S.4
  • 107
    • 0032710609 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease
    • Liberatore G.T., Jackson-Lewis V., Vukosavic S., Mandir A.S., Vila M., McAuliffe W.G., et al. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat Med 1999, 5:1403-1409.
    • (1999) Nat Med , vol.5 , pp. 1403-1409
    • Liberatore, G.T.1    Jackson-Lewis, V.2    Vukosavic, S.3    Mandir, A.S.4    Vila, M.5    McAuliffe, W.G.6
  • 108
    • 0035869637 scopus 로고    scopus 로고
    • Regulation of microglial development: a novel role for thyroid hormone
    • Lima F.R., Gervais A., Colin C., Izembart M., Neto V.M., Mallat M. Regulation of microglial development: a novel role for thyroid hormone. J Neurosci 2001, 21:2028-2038.
    • (2001) J Neurosci , vol.21 , pp. 2028-2038
    • Lima, F.R.1    Gervais, A.2    Colin, C.3    Izembart, M.4    Neto, V.M.5    Mallat, M.6
  • 109
    • 70350450344 scopus 로고    scopus 로고
    • Lipoplysaccharide preconditioning reduces neuroinflammation against hypoxic ischemia and provides long-term outcome of neuroprotection in the neonatal rat
    • Lin H.Y., Huang C.C., Chang K.F. Lipoplysaccharide preconditioning reduces neuroinflammation against hypoxic ischemia and provides long-term outcome of neuroprotection in the neonatal rat. Pediatr Res 2009, 66:254-259.
    • (2009) Pediatr Res , vol.66 , pp. 254-259
    • Lin, H.Y.1    Huang, C.C.2    Chang, K.F.3
  • 110
    • 0015959071 scopus 로고
    • Amoeboid microglial cells in the corpus callosum of neonatal rats
    • Ling E.A., Tan C.K. Amoeboid microglial cells in the corpus callosum of neonatal rats. Arch Histol Jpn 1974, 36:265-280.
    • (1974) Arch Histol Jpn , vol.36 , pp. 265-280
    • Ling, E.A.1    Tan, C.K.2
  • 111
    • 0027343619 scopus 로고
    • The origin and nature of ramified and amoeboid microglia: a historical review and current concepts
    • Ling E.A., Wong W.C. The origin and nature of ramified and amoeboid microglia: a historical review and current concepts. Glia 1993, 7:9-18.
    • (1993) Glia , vol.7 , pp. 9-18
    • Ling, E.A.1    Wong, W.C.2
  • 112
    • 0019129071 scopus 로고
    • Use of carbon labeling to demonstrate the role of blood monocytes as precursors of the amoeboid cells present in the corpus callosum of postnatal rats
    • Ling E.A., Penney D., Leblond D.P. Use of carbon labeling to demonstrate the role of blood monocytes as precursors of the amoeboid cells present in the corpus callosum of postnatal rats. J Comp Neurol 1980, 193:631-657.
    • (1980) J Comp Neurol , vol.193 , pp. 631-657
    • Ling, E.A.1    Penney, D.2    Leblond, D.P.3
  • 113
    • 77950826971 scopus 로고    scopus 로고
    • Microglia in the aging brain: relevance to neurodegeneration
    • Luo X.G., Ding J.Z., Chen S.D. Microglia in the aging brain: relevance to neurodegeneration. Mol Neurodegeneration 2010, 5:12.
    • (2010) Mol Neurodegeneration , vol.5 , pp. 12
    • Luo, X.G.1    Ding, J.Z.2    Chen, S.D.3
  • 114
    • 13844275290 scopus 로고    scopus 로고
    • Phagocytosis in the developing CNS: more than clearing the corpses
    • Mallat M., Marin-Teva J.L., Cheret C. Phagocytosis in the developing CNS: more than clearing the corpses. Curr Opin Neurobiol 2005, 15:101-107.
    • (2005) Curr Opin Neurobiol , vol.15 , pp. 101-107
    • Mallat, M.1    Marin-Teva, J.L.2    Cheret, C.3
  • 115
    • 0030958169 scopus 로고    scopus 로고
    • Induction of tumor necrosis factor alpha in cultured glial cells by trimethyltin
    • Maier W.E., Bartenbach M.J., Brown H.A., Tilson H.A., Harry G.J. Induction of tumor necrosis factor alpha in cultured glial cells by trimethyltin. Neurochem Int 1997, 30:385-392.
    • (1997) Neurochem Int , vol.30 , pp. 385-392
    • Maier, W.E.1    Bartenbach, M.J.2    Brown, H.A.3    Tilson, H.A.4    Harry, G.J.5
  • 116
    • 0022347657 scopus 로고
    • Embryonic vascularization of the mammalian cerebral cortex: golgi and electron microscopic studies
    • Marin-Padilla M. Embryonic vascularization of the mammalian cerebral cortex: golgi and electron microscopic studies. J Comp Neurol 1985, 241:237-249.
    • (1985) J Comp Neurol , vol.241 , pp. 237-249
    • Marin-Padilla, M.1
  • 118
    • 80052791226 scopus 로고    scopus 로고
    • Capillary blood flow around microglial somata determines dynamics of microglial processes in ischemic conditions
    • Masuda T., Croom D., Hida H., Kirov S.A. Capillary blood flow around microglial somata determines dynamics of microglial processes in ischemic conditions. Glia 2011, 59:1744-1753.
    • (2011) Glia , vol.59 , pp. 1744-1753
    • Masuda, T.1    Croom, D.2    Hida, H.3    Kirov, S.A.4
  • 119
    • 0345999337 scopus 로고
    • Absence of donor-type major histocompatibility complex class I antigen bearing microglia in the rat central nervous system of radiation bone marrow chimeras
    • Matsumoto Y., Fujiwara M. Absence of donor-type major histocompatibility complex class I antigen bearing microglia in the rat central nervous system of radiation bone marrow chimeras. J Neuroimmunol 1987, 17:71-82.
    • (1987) J Neuroimmunol , vol.17 , pp. 71-82
    • Matsumoto, Y.1    Fujiwara, M.2
  • 120
    • 0025339720 scopus 로고
    • Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors
    • Mattiace L.A., Davies P., Dickson D.W. Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors. Am J Pathol 1990, 136:1101-1114.
    • (1990) Am J Pathol , vol.136 , pp. 1101-1114
    • Mattiace, L.A.1    Davies, P.2    Dickson, D.W.3
  • 121
    • 0023912069 scopus 로고
    • Radioautographic evidence for slow astrocyte turnover and modest oligodendrocyte production in the corpus callosum of adult mice infused with 3H-thymidine
    • McCarthy G.F., Leblond C.P. Radioautographic evidence for slow astrocyte turnover and modest oligodendrocyte production in the corpus callosum of adult mice infused with 3H-thymidine. J Comp Neurol 1988, 271:589-603.
    • (1988) J Comp Neurol , vol.271 , pp. 589-603
    • McCarthy, G.F.1    Leblond, C.P.2
  • 123
    • 33748702290 scopus 로고    scopus 로고
    • Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease
    • McCoy M.K., Martinez T.N., Ruhn K.A., Szymkowski D.E., Smith C.G., Botterman B.R., et al. Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease. J Neurosci 2006, 26:9365-9375.
    • (2006) J Neurosci , vol.26 , pp. 9365-9375
    • McCoy, M.K.1    Martinez, T.N.2    Ruhn, K.A.3    Szymkowski, D.E.4    Smith, C.G.5    Botterman, B.R.6
  • 124
    • 0029610011 scopus 로고
    • The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases
    • McGeer P.L., McGeer E.G. The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res Brain Res Rev 1995, 21:195-218.
    • (1995) Brain Res Brain Res Rev , vol.21 , pp. 195-218
    • McGeer, P.L.1    McGeer, E.G.2
  • 125
    • 79751537734 scopus 로고    scopus 로고
    • Injury-induced neurogenesis: consideration of resident microglia as supportive of neural progenitor cells
    • McPherson C.A., Kraft A.D., Harry G.J. Injury-induced neurogenesis: consideration of resident microglia as supportive of neural progenitor cells. Neurotox Res 2011, 19:341-352.
    • (2011) Neurotox Res , vol.19 , pp. 341-352
    • McPherson, C.A.1    Kraft, A.D.2    Harry, G.J.3
  • 127
    • 67649464224 scopus 로고    scopus 로고
    • In vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders
    • Meyer U., Feldon J., Fatemi S.H. In vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders. Neurosci Biobehav Rev 2009, 33:1061-1079.
    • (2009) Neurosci Biobehav Rev , vol.33 , pp. 1061-1079
    • Meyer, U.1    Feldon, J.2    Fatemi, S.H.3
  • 129
    • 0035105538 scopus 로고    scopus 로고
    • Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude
    • Mittelbronn M., Dietz K., Schluesener J.H., Meyermann R. Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude. Acta Neuropathol 2001, 101:249-255.
    • (2001) Acta Neuropathol , vol.101 , pp. 249-255
    • Mittelbronn, M.1    Dietz, K.2    Schluesener, J.H.3    Meyermann, R.4
  • 130
    • 80053281065 scopus 로고    scopus 로고
    • Interleukin-34 selectively enhances the neuroprotective effects of microglia to attenuate oligomeric amyloid-β neurotoxicity
    • Mizuno T., Doi Y., Zizoguchi H., Jin S., Noda M., Sonobe Y., et al. Interleukin-34 selectively enhances the neuroprotective effects of microglia to attenuate oligomeric amyloid-β neurotoxicity. Am J Pathol 2011, 179:2016-2027.
    • (2011) Am J Pathol , vol.179 , pp. 2016-2027
    • Mizuno, T.1    Doi, Y.2    Zizoguchi, H.3    Jin, S.4    Noda, M.5    Sonobe, Y.6
  • 131
    • 77953512334 scopus 로고    scopus 로고
    • Early life activation of toll-like receptor 4 reprograms neural anti-inflammatory pathways
    • Mouihate A., Galic M.A., Ellis S.L., Spencer S.J., Tsutsui S., Pittman Q.J. Early life activation of toll-like receptor 4 reprograms neural anti-inflammatory pathways. J Neurosci 2010, 30:7975-7983.
    • (2010) J Neurosci , vol.30 , pp. 7975-7983
    • Mouihate, A.1    Galic, M.A.2    Ellis, S.L.3    Spencer, S.J.4    Tsutsui, S.5    Pittman, Q.J.6
  • 132
    • 33750213032 scopus 로고    scopus 로고
    • Distribution and differentiation of microglia in the human encephalon during the first two trimesters of gestation
    • Monier A., Evrard P., Gressens P., Verney C. Distribution and differentiation of microglia in the human encephalon during the first two trimesters of gestation. J Comp Neurol 2006, 499:565-582.
    • (2006) J Comp Neurol , vol.499 , pp. 565-582
    • Monier, A.1    Evrard, P.2    Gressens, P.3    Verney, C.4
  • 133
    • 74949127037 scopus 로고    scopus 로고
    • Developmental exposure to manganese increases adult susceptibility to inflammatory activation of glia and neuronal protein nitration
    • Moreno J.A., Streifel K.M., Sullivan K.A., Legare M.E., Tjalkens R.B. Developmental exposure to manganese increases adult susceptibility to inflammatory activation of glia and neuronal protein nitration. Toxicol Sci 2009, 112:405-415.
    • (2009) Toxicol Sci , vol.112 , pp. 405-415
    • Moreno, J.A.1    Streifel, K.M.2    Sullivan, K.A.3    Legare, M.E.4    Tjalkens, R.B.5
  • 134
    • 79960993418 scopus 로고    scopus 로고
    • Manganese-induced NF-kB activation and nitrosative stress is decreased by estrogen in juvenile mice
    • Moreno J.A., Streifel K.M., Sullivan K.A., Hanneman W.H., Tjalkens R.B. Manganese-induced NF-kB activation and nitrosative stress is decreased by estrogen in juvenile mice. Toxicol Sci 2011, 122:121-133.
    • (2011) Toxicol Sci , vol.122 , pp. 121-133
    • Moreno, J.A.1    Streifel, K.M.2    Sullivan, K.A.3    Hanneman, W.H.4    Tjalkens, R.B.5
  • 135
    • 0025893822 scopus 로고
    • Macrophages in haemopoietic and other tissues of the developing mouse detected by the monoclonal antibody F4/80
    • Morris L., Graham C.F., Gordon S. Macrophages in haemopoietic and other tissues of the developing mouse detected by the monoclonal antibody F4/80. Development 1991, 112:517-526.
    • (1991) Development , vol.112 , pp. 517-526
    • Morris, L.1    Graham, C.F.2    Gordon, S.3
  • 136
    • 2542421703 scopus 로고    scopus 로고
    • Neuronal expression of CD22: novel mechanism for inhibiting microglial proinflammatory cytokine production
    • Mott R.T., Ait-Ghezala G., Town T., Mori T., Vendrame M., Zeng J., et al. Neuronal expression of CD22: novel mechanism for inhibiting microglial proinflammatory cytokine production. Glia 2004, 46:369-379.
    • (2004) Glia , vol.46 , pp. 369-379
    • Mott, R.T.1    Ait-Ghezala, G.2    Town, T.3    Mori, T.4    Vendrame, M.5    Zeng, J.6
  • 137
    • 0344157469 scopus 로고    scopus 로고
    • The role of tumour necrosis factor, interleukin 6, interferon-gamma and inducible nitric oxide synthase in the development and pathology of the nervous system
    • Munoz-Fernandez M.A., Fresno M. The role of tumour necrosis factor, interleukin 6, interferon-gamma and inducible nitric oxide synthase in the development and pathology of the nervous system. Prog Neurobiol 1998, 56:307-340.
    • (1998) Prog Neurobiol , vol.56 , pp. 307-340
    • Munoz-Fernandez, M.A.1    Fresno, M.2
  • 138
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A., Kirchhoff F., Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005, 308:1314-1318.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 140
    • 0002679258 scopus 로고
    • Ueber einige Beziehungen zwishcen Nerven zellerkrankungen und glioesen Erscheinungen bei verschiedenen Psychosen
    • Nissl F. Ueber einige Beziehungen zwishcen Nerven zellerkrankungen und glioesen Erscheinungen bei verschiedenen Psychosen. Arch Psychiat 1899, 32:1-21.
    • (1899) Arch Psychiat , vol.32 , pp. 1-21
    • Nissl, F.1
  • 141
    • 33745988227 scopus 로고    scopus 로고
    • Role of interleukin-6 in lipopolysaccharide-induced brain injury and behavioral dysfunction in neonatal rats
    • Pang Y., Fan L.-W., Zheng B., Cai Z., Rhodes P.G. Role of interleukin-6 in lipopolysaccharide-induced brain injury and behavioral dysfunction in neonatal rats. Neurosci 2006, 141:745-755.
    • (2006) Neurosci , vol.141 , pp. 745-755
    • Pang, Y.1    Fan, L.-W.2    Zheng, B.3    Cai, Z.4    Rhodes, P.G.5
  • 142
  • 143
    • 0023553325 scopus 로고
    • Modulation of CD4 antigen on macrophages and microglia in rat brain
    • Perry V.H., Gordon S. Modulation of CD4 antigen on macrophages and microglia in rat brain. J Exp Med 1987, 166:1138-1143.
    • (1987) J Exp Med , vol.166 , pp. 1138-1143
    • Perry, V.H.1    Gordon, S.2
  • 144
    • 78650063641 scopus 로고    scopus 로고
    • The role of microglia in synaptic stripping and synaptic degeneration: a revised perspective
    • Perry V.H., O'Connor V. The role of microglia in synaptic stripping and synaptic degeneration: a revised perspective. ASN Neuro 2010, 2.
    • (2010) ASN Neuro , vol.2
    • Perry, V.H.1    O'Connor, V.2
  • 145
    • 0022387412 scopus 로고
    • Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain
    • Perry V.H., Hume D.A., Gordon S. Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain. Neuroscience 1985, 15:313-326.
    • (1985) Neuroscience , vol.15 , pp. 313-326
    • Perry, V.H.1    Hume, D.A.2    Gordon, S.3
  • 146
    • 0027352040 scopus 로고
    • Altered antigen expression of microglia in the aged rodent CNS
    • Perry V.H., Matyszak M.K., Fearn S. Altered antigen expression of microglia in the aged rodent CNS. Glia 1993, 7:60-67.
    • (1993) Glia , vol.7 , pp. 60-67
    • Perry, V.H.1    Matyszak, M.K.2    Fearn, S.3
  • 147
    • 0028920736 scopus 로고
    • CD14 receptor-mediated uptake of monopsonised Mycobacterium tuberculosis by human microglia
    • Peterson P.K., Gekker G., Hu S., Sheng W.S., Anderson W.R., Ulevitch R.J., et al. CD14 receptor-mediated uptake of monopsonised Mycobacterium tuberculosis by human microglia. Infect Immun 1995, 63:1598-1602.
    • (1995) Infect Immun , vol.63 , pp. 1598-1602
    • Peterson, P.K.1    Gekker, G.2    Hu, S.3    Sheng, W.S.4    Anderson, W.R.5    Ulevitch, R.J.6
  • 148
    • 34848843543 scopus 로고    scopus 로고
    • Neurotransmitter receptors on microglia
    • Pocock J.M., Kettenmann H. Neurotransmitter receptors on microglia. Trends Neurosci 2007, 30:527-535.
    • (2007) Trends Neurosci , vol.30 , pp. 527-535
    • Pocock, J.M.1    Kettenmann, H.2
  • 149
    • 14644400486 scopus 로고    scopus 로고
    • No phenotype associated with established lipopolysaccharide model for cerebral palsy
    • Poggi S.H., Park J., Toso L., Abebe D., Roberson R., Woodard J.E., et al. No phenotype associated with established lipopolysaccharide model for cerebral palsy. J Obstet Gynecol 2005, 192:727-733.
    • (2005) J Obstet Gynecol , vol.192 , pp. 727-733
    • Poggi, S.H.1    Park, J.2    Toso, L.3    Abebe, D.4    Roberson, R.5    Woodard, J.E.6
  • 151
    • 33745266414 scopus 로고    scopus 로고
    • Triggering receptor expressed in myeloid cells 2 (TREM2) trafficking in microglial cells: continuous shuttling to and from the plasma membrane regulated by cell stimulation
    • Prada I., Ongania G.N., Buonsanti C., Panina-Bordignon P., Meldolesi J. Triggering receptor expressed in myeloid cells 2 (TREM2) trafficking in microglial cells: continuous shuttling to and from the plasma membrane regulated by cell stimulation. Neuroscience 2006, 140:1139-1148.
    • (2006) Neuroscience , vol.140 , pp. 1139-1148
    • Prada, I.1    Ongania, G.N.2    Buonsanti, C.3    Panina-Bordignon, P.4    Meldolesi, J.5
  • 152
    • 0029451822 scopus 로고
    • Calcitonin gene-related peptide and ATP induce immediate early gene expression in cultured rat microglia cells
    • Priller J., Haas C.A., Reddington M., Kreutzberg G.W. Calcitonin gene-related peptide and ATP induce immediate early gene expression in cultured rat microglia cells. Glia 1995, 15:447-457.
    • (1995) Glia , vol.15 , pp. 447-457
    • Priller, J.1    Haas, C.A.2    Reddington, M.3    Kreutzberg, G.W.4
  • 153
    • 0033811463 scopus 로고    scopus 로고
    • Programmed cell death in the developing human telencephalon
    • Rakic S., Zecevic N. Programmed cell death in the developing human telencephalon. Eur J Neurosci 2000, 12:2721-2734.
    • (2000) Eur J Neurosci , vol.12 , pp. 2721-2734
    • Rakic, S.1    Zecevic, N.2
  • 154
    • 67650966680 scopus 로고    scopus 로고
    • Microglial physiology: unique stimuli, specialized responses
    • Ransohoff R.M., Perry V.H. Microglial physiology: unique stimuli, specialized responses. Annu Rev Immunol 2009, 27:119-145.
    • (2009) Annu Rev Immunol , vol.27 , pp. 119-145
    • Ransohoff, R.M.1    Perry, V.H.2
  • 155
    • 26944453586 scopus 로고    scopus 로고
    • Like cops on the beat, the active role of resting microglia
    • Raivich G. Like cops on the beat, the active role of resting microglia. Trends Neurosci 2005, 28:571-573.
    • (2005) Trends Neurosci , vol.28 , pp. 571-573
    • Raivich, G.1
  • 156
    • 0033564675 scopus 로고    scopus 로고
    • Colonisation of the developing human brain and spinal cord by microglia: a review
    • Rezaie P., Male D. Colonisation of the developing human brain and spinal cord by microglia: a review. Microsc Res Tech 1999, 45:359-382.
    • (1999) Microsc Res Tech , vol.45 , pp. 359-382
    • Rezaie, P.1    Male, D.2
  • 157
    • 0344874240 scopus 로고    scopus 로고
    • Microglia in fetal and adult human brain can be distinguished from other mononuclear phagocytes through their lack of CD163 expression
    • Rezaie P., Male D. Microglia in fetal and adult human brain can be distinguished from other mononuclear phagocytes through their lack of CD163 expression. Neuroembryology 2003, 2:130-133.
    • (2003) Neuroembryology , vol.2 , pp. 130-133
    • Rezaie, P.1    Male, D.2
  • 158
    • 0031578947 scopus 로고    scopus 로고
    • Expression of adhesion molecules on human fetal cerebral vessels: relationship to microglial colonization during development
    • Rezaie P., Cairns N.J., Male D.K. Expression of adhesion molecules on human fetal cerebral vessels: relationship to microglial colonization during development. Brain Res Dev Brain Res 1997, 104:175-189.
    • (1997) Brain Res Dev Brain Res , vol.104 , pp. 175-189
    • Rezaie, P.1    Cairns, N.J.2    Male, D.K.3
  • 159
    • 20544449468 scopus 로고    scopus 로고
    • Microglia in the cerebral wall of the human telencephalon at second trimester
    • Rezaie P., Dean A., Male D., Ulfig N. Microglia in the cerebral wall of the human telencephalon at second trimester. Cerebral Cortex 2005, 15:938-949.
    • (2005) Cerebral Cortex , vol.15 , pp. 938-949
    • Rezaie, P.1    Dean, A.2    Male, D.3    Ulfig, N.4
  • 161
    • 36148998691 scopus 로고    scopus 로고
    • Bone-marrow-derived cell differentiation into microglia: a study in a progressive mouse model of Parkinson's disease
    • Rodriquez M., Alvarez-Erviti L., Blesa F.J., Rodriquez-Oroz M.C., Arina A., Melero I., et al. Bone-marrow-derived cell differentiation into microglia: a study in a progressive mouse model of Parkinson's disease. Neurobiol Dis 2007, 28:316-325.
    • (2007) Neurobiol Dis , vol.28 , pp. 316-325
    • Rodriquez, M.1    Alvarez-Erviti, L.2    Blesa, F.J.3    Rodriquez-Oroz, M.C.4    Arina, A.5    Melero, I.6
  • 162
  • 163
    • 79251551934 scopus 로고    scopus 로고
    • A two-way communication between microglial cells and angiogenic sprouts regulates angiogenesis in aortic ring cultures
    • Rymo S.F., Gerhardt H., Wolfhagen Sand F., Lang R., Uv A., Betsholtz C. A two-way communication between microglial cells and angiogenic sprouts regulates angiogenesis in aortic ring cultures. PLoS One 2011, 6:e15846.
    • (2011) PLoS One , vol.6
    • Rymo, S.F.1    Gerhardt, H.2    Wolfhagen Sand, F.3    Lang, R.4    Uv, A.5    Betsholtz, C.6
  • 164
    • 67849121525 scopus 로고    scopus 로고
    • Fibrinogen signal transduction in the nervous system
    • Ryu J.K., Davalos D., Akassoglou K. Fibrinogen signal transduction in the nervous system. J Thromb Haemost 2009, 7:S151-S154.
    • (2009) J Thromb Haemost , vol.7
    • Ryu, J.K.1    Davalos, D.2    Akassoglou, K.3
  • 165
    • 0035079119 scopus 로고    scopus 로고
    • Inflammatory mediators and neonatal brain damage
    • Saliba E., Henrot A. Inflammatory mediators and neonatal brain damage. Biol Neonate 2001, 79:224-227.
    • (2001) Biol Neonate , vol.79 , pp. 224-227
    • Saliba, E.1    Henrot, A.2
  • 166
    • 33646472435 scopus 로고    scopus 로고
    • Prenatal exposure to interleukin-6 results in inflammatory neurodegeneration in hippocampus with NMDA/GABA(A) dysregulation and impaired spatial learning
    • Samuelsson A.M., Jennische E., Hansson H.A., Holmang A. Prenatal exposure to interleukin-6 results in inflammatory neurodegeneration in hippocampus with NMDA/GABA(A) dysregulation and impaired spatial learning. Am J Physiol Regul Integr Comp Physiol 2006, 290:R1345-R1356.
    • (2006) Am J Physiol Regul Integr Comp Physiol , vol.290
    • Samuelsson, A.M.1    Jennische, E.2    Hansson, H.A.3    Holmang, A.4
  • 167
    • 77953271370 scopus 로고    scopus 로고
    • Synapse elimination during development and disease: immune molecules take centre stage
    • Schafer D.P., Stevens B. Synapse elimination during development and disease: immune molecules take centre stage. Biochem Soc Trans 2010, 38:476-481.
    • (2010) Biochem Soc Trans , vol.38 , pp. 476-481
    • Schafer, D.P.1    Stevens, B.2
  • 168
    • 79952068402 scopus 로고    scopus 로고
    • Microglia in the developing brain: from immunity to behavior
    • Schlegelmilch T., Henke K., Peri F. Microglia in the developing brain: from immunity to behavior. Curr Opin Neurobiol 2011, 21:5-10.
    • (2011) Curr Opin Neurobiol , vol.21 , pp. 5-10
    • Schlegelmilch, T.1    Henke, K.2    Peri, F.3
  • 169
    • 64349105022 scopus 로고    scopus 로고
    • Differential gene expression in LPS/IFNgamma activated microglia and macrophages: in vitro versus in vivo
    • Schmid C.D., Melchior B., Masek K., Puntambekar S.S., Danielson P.E., Lo D.D. Differential gene expression in LPS/IFNgamma activated microglia and macrophages: in vitro versus in vivo. J Neurochem 2009, 109:117-125.
    • (2009) J Neurochem , vol.109 , pp. 117-125
    • Schmid, C.D.1    Melchior, B.2    Masek, K.3    Puntambekar, S.S.4    Danielson, P.E.5    Lo, D.D.6
  • 170
    • 83055169214 scopus 로고    scopus 로고
    • Early-life experience decreases drug-induced reinstatement of morphing CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression
    • Schwarz J.M., Hutchinson M.R., Bilbo S.D. Early-life experience decreases drug-induced reinstatement of morphing CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression. J Neurosci 2011, 31:17835-17847.
    • (2011) J Neurosci , vol.31 , pp. 17835-17847
    • Schwarz, J.M.1    Hutchinson, M.R.2    Bilbo, S.D.3
  • 171
    • 0042977534 scopus 로고    scopus 로고
    • Macrophage-mediated corpse engulfment is required for normal Drosophila CNS morphogenesis
    • Sears H.C., Kennedy C.J., Garrity P.A. Macrophage-mediated corpse engulfment is required for normal Drosophila CNS morphogenesis. Development 2003, 130:3557-3565.
    • (2003) Development , vol.130 , pp. 3557-3565
    • Sears, H.C.1    Kennedy, C.J.2    Garrity, P.A.3
  • 172
    • 0025900245 scopus 로고
    • Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system
    • Sedgwick J.D., Schwender S., Imrich H., Dorries R., Butcher G.W., ter Meulen V. Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system. Proc Natl Acad Sci USA 1991, 88:7438-7442.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 7438-7442
    • Sedgwick, J.D.1    Schwender, S.2    Imrich, H.3    Dorries, R.4    Butcher, G.W.5    ter Meulen, V.6
  • 173
    • 0031960498 scopus 로고    scopus 로고
    • Microglial expression of MHC class II increases in normal aging of nonhuman primates
    • Sheffield L.G., Berman N.E. Microglial expression of MHC class II increases in normal aging of nonhuman primates. Neurobiol Aging 1998, 19:47-55.
    • (1998) Neurobiol Aging , vol.19 , pp. 47-55
    • Sheffield, L.G.1    Berman, N.E.2
  • 174
    • 3543144446 scopus 로고
    • Dendritic organization in the neurons of the visual and motor cortices of the cat
    • Sholl D.A. Dendritic organization in the neurons of the visual and motor cortices of the cat. J Anat 1953, 87:387-406.
    • (1953) J Anat , vol.87 , pp. 387-406
    • Sholl, D.A.1
  • 176
    • 35148872226 scopus 로고    scopus 로고
    • Maternal immune activation alters fetal brain development through interleukin-6
    • Smith S.E.P., Li J., Garbett K., Mirnics K., Patterson P.H. Maternal immune activation alters fetal brain development through interleukin-6. J Neurosci 2007, 27:10695-10702.
    • (2007) J Neurosci , vol.27 , pp. 10695-10702
    • Smith, S.E.P.1    Li, J.2    Garbett, K.3    Mirnics, K.4    Patterson, P.H.5
  • 177
    • 33646199097 scopus 로고    scopus 로고
    • Synaptic scaling mediated by glial TNF-alpha
    • Stellwagen D., Malenka R.C. Synaptic scaling mediated by glial TNF-alpha. Nature 2006, 440:1054-1059.
    • (2006) Nature , vol.440 , pp. 1054-1059
    • Stellwagen, D.1    Malenka, R.C.2
  • 179
    • 1042291300 scopus 로고    scopus 로고
    • Dystrophic microglia in the aging human brain
    • Streit W.J., Sammons N.W., Kuhns A.J., Sparks D.L. Dystrophic microglia in the aging human brain. Glia 2004, 45:208-212.
    • (2004) Glia , vol.45 , pp. 208-212
    • Streit, W.J.1    Sammons, N.W.2    Kuhns, A.J.3    Sparks, D.L.4
  • 180
    • 20144363592 scopus 로고    scopus 로고
    • Quantitative morphological study of microglial cells in the ischemic rat brain using principal component analysis
    • Soltys Z., Orzylowska-Sliwinska O., Zaremba M., Orlowski D., Piechota M., Fiedorowicz A., et al. Quantitative morphological study of microglial cells in the ischemic rat brain using principal component analysis. J Neurosci Methods 2005, 146:50-60.
    • (2005) J Neurosci Methods , vol.146 , pp. 50-60
    • Soltys, Z.1    Orzylowska-Sliwinska, O.2    Zaremba, M.3    Orlowski, D.4    Piechota, M.5    Fiedorowicz, A.6
  • 181
    • 42649098547 scopus 로고    scopus 로고
    • Microglial degeneration in the aging brain - bad news for neurons
    • Streit W.J., Miller K.R., Lopes K.O., Njie E. Microglial degeneration in the aging brain - bad news for neurons. Front Biosci 2008, 13:3423-3438.
    • (2008) Front Biosci , vol.13 , pp. 3423-3438
    • Streit, W.J.1    Miller, K.R.2    Lopes, K.O.3    Njie, E.4
  • 182
    • 0024340657 scopus 로고
    • Expression of Ia antigens on perivascular and microglial cells after sublethal and lethal neuronal injury
    • Streit W.J., Graeber M.B., Kreutzberg G.W. Expression of Ia antigens on perivascular and microglial cells after sublethal and lethal neuronal injury. Exp Neurol 1989, 105:115-126.
    • (1989) Exp Neurol , vol.105 , pp. 115-126
    • Streit, W.J.1    Graeber, M.B.2    Kreutzberg, G.W.3
  • 183
    • 21244443731 scopus 로고    scopus 로고
    • Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences
    • Stout R.D., Jiang C., Matta B., Tietzel I., Watkins S.K., Suttles J. Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences. J Immunol 2005, 175:342-349.
    • (2005) J Immunol , vol.175 , pp. 342-349
    • Stout, R.D.1    Jiang, C.2    Matta, B.3    Tietzel, I.4    Watkins, S.K.5    Suttles, J.6
  • 184
    • 79953321796 scopus 로고    scopus 로고
    • Cold stress induced morphological microglial activation and increased IL-1b expression in astroglial cells in rat brain
    • Sugama S., Takenouchi T., Fujita M., Kitani H., Hashimoto M. Cold stress induced morphological microglial activation and increased IL-1b expression in astroglial cells in rat brain. J Neuroimmunol 2011, 233:29-36.
    • (2011) J Neuroimmunol , vol.233 , pp. 29-36
    • Sugama, S.1    Takenouchi, T.2    Fujita, M.3    Kitani, H.4    Hashimoto, M.5
  • 185
    • 34247500821 scopus 로고    scopus 로고
    • TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis
    • Takahashi K., Prinz M., Stagi M., Chechneva O., Neumann H. TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis. PLoS Med 2007, 4:e124.
    • (2007) PLoS Med , vol.4
    • Takahashi, K.1    Prinz, M.2    Stagi, M.3    Chechneva, O.4    Neumann, H.5
  • 186
    • 58149459143 scopus 로고    scopus 로고
    • Developmental regulation of TRAM2 and DAP12 expression in the mouse CNS: implications for Nasu-Hakola disease
    • Thrash J.C., Torbett B.E., Carson M.J. Developmental regulation of TRAM2 and DAP12 expression in the mouse CNS: implications for Nasu-Hakola disease. Neurochem Res 2009, 34:38-45.
    • (2009) Neurochem Res , vol.34 , pp. 38-45
    • Thrash, J.C.1    Torbett, B.E.2    Carson, M.J.3
  • 187
    • 84855252961 scopus 로고    scopus 로고
    • Differential mRNA expression of neuroimmune markers in the hippocampus of infant mice following toluene exposure during brain developmental period
    • Tin-Tin Win-Shwe, Kunugita N., Yoshida Y., Nakajima D., Tsukahara S., Fujimaki H. Differential mRNA expression of neuroimmune markers in the hippocampus of infant mice following toluene exposure during brain developmental period. J Appl Toxicol 2011, 10.1002/jat.1643.
    • (2011) J Appl Toxicol
    • Tin-Tin Win-Shwe1    Kunugita, N.2    Yoshida, Y.3    Nakajima, D.4    Tsukahara, S.5    Fujimaki, H.6
  • 189
    • 78649976052 scopus 로고    scopus 로고
    • Microglial interactions with synapses are modulated by visual experience
    • Tremblay M.È., Lowery R.L., Majewska A.K. Microglial interactions with synapses are modulated by visual experience. PLoS Biol 2010, 8:e1000527.
    • (2010) PLoS Biol , vol.8
    • Tremblay, M.È.1    Lowery, R.L.2    Majewska, A.K.3
  • 190
    • 0015276610 scopus 로고
    • The mononuclear phagocyte system: a new classification of macrophages, monocytes, and their precursor cells
    • Van Furth R., Cohn Z.A., Hirsch J.G., Humphrey J.H., Spector W.G., Langevoort H.L. The mononuclear phagocyte system: a new classification of macrophages, monocytes, and their precursor cells. Bull WHO 1972, 46:845-852.
    • (1972) Bull WHO , vol.46 , pp. 845-852
    • Van Furth, R.1    Cohn, Z.A.2    Hirsch, J.G.3    Humphrey, J.H.4    Spector, W.G.5    Langevoort, H.L.6
  • 192
    • 65249157852 scopus 로고    scopus 로고
    • Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals
    • Wake H., Moorhouse A.J., Jinno S., Kohsaka S., Nabekura J. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J Neurosci 2009, 29:3974-3980.
    • (2009) J Neurosci , vol.29 , pp. 3974-3980
    • Wake, H.1    Moorhouse, A.J.2    Jinno, S.3    Kohsaka, S.4    Nabekura, J.5
  • 193
    • 0027426013 scopus 로고
    • Extracellular ATP activates a cation conductance and a K+ conductance in cultured microglial cells from mouse brain
    • Walz W., Ilschner S., Ohlemeyer C., Banati R., Kettenmann H. Extracellular ATP activates a cation conductance and a K+ conductance in cultured microglial cells from mouse brain. J Neurosci 1993, 13:4403-4411.
    • (1993) J Neurosci , vol.13 , pp. 4403-4411
    • Walz, W.1    Ilschner, S.2    Ohlemeyer, C.3    Banati, R.4    Kettenmann, H.5
  • 194
    • 0037115056 scopus 로고    scopus 로고
    • Microglial distribution and apoptosis in fetal rat brain
    • Wang C.C., Wu C.H., Shieh J.H., Wen C.Y. Microglial distribution and apoptosis in fetal rat brain. Dev Brain Res 2002, 139:337-342.
    • (2002) Dev Brain Res , vol.139 , pp. 337-342
    • Wang, C.C.1    Wu, C.H.2    Shieh, J.H.3    Wen, C.Y.4
  • 195
    • 51149091666 scopus 로고    scopus 로고
    • Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor
    • Wakselman S., Bechade C., Roumier A., Bernard D., Triller A., Bessis A. Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor. J Neurosci 2008, 28:8138-8143.
    • (2008) J Neurosci , vol.28 , pp. 8138-8143
    • Wakselman, S.1    Bechade, C.2    Roumier, A.3    Bernard, D.4    Triller, A.5    Bessis, A.6
  • 196
    • 70350654793 scopus 로고    scopus 로고
    • Neuro-inflammation induced in the hippocampus of 'binge drinking' rats may be mediated by elevated extracellular glutamate content
    • Ward R.J., Colivicchi M.A., Allen R., Schol F., Lallemand F., de Witte P., et al. Neuro-inflammation induced in the hippocampus of 'binge drinking' rats may be mediated by elevated extracellular glutamate content. J Neurochem 2009, 111:1119-1128.
    • (2009) J Neurochem , vol.111 , pp. 1119-1128
    • Ward, R.J.1    Colivicchi, M.A.2    Allen, R.3    Schol, F.4    Lallemand, F.5    de Witte, P.6
  • 197
    • 84858007228 scopus 로고    scopus 로고
    • Early life stress inhibits expression of a novel innate immune pathway in the developing hippocampus
    • [Epub]
    • Wei L., Simen A., Mane S., Kaffman A. Early life stress inhibits expression of a novel innate immune pathway in the developing hippocampus. Neuropsychopharmacology 2011, [Epub].
    • (2011) Neuropsychopharmacology
    • Wei, L.1    Simen, A.2    Mane, S.3    Kaffman, A.4
  • 198
    • 0030701949 scopus 로고    scopus 로고
    • Production of peptide hormones and neurotransmitters by the immune system
    • Weigent D.A., Blalock J.E. Production of peptide hormones and neurotransmitters by the immune system. Chem Immunol 1997, 69:1-30.
    • (1997) Chem Immunol , vol.69 , pp. 1-30
    • Weigent, D.A.1    Blalock, J.E.2
  • 199
    • 0028062835 scopus 로고
    • Immune regulatory and effector properties of human adult microglia studies in vitro and in situ
    • Williams K., Ulvestad E., Antel J. Immune regulatory and effector properties of human adult microglia studies in vitro and in situ. Adv Neuroimmunol 1994, 4:273-281.
    • (1994) Adv Neuroimmunol , vol.4 , pp. 273-281
    • Williams, K.1    Ulvestad, E.2    Antel, J.3
  • 200
    • 0031040803 scopus 로고    scopus 로고
    • Ramification of microglia, monocytes and macrophages in vitro: influences of various epithelial and mesenchymal cells and their conditioned media
    • Wilms H., Hartmann D., Sievers J. Ramification of microglia, monocytes and macrophages in vitro: influences of various epithelial and mesenchymal cells and their conditioned media. Cell Tissue Res 1997, 287:447-458.
    • (1997) Cell Tissue Res , vol.287 , pp. 447-458
    • Wilms, H.1    Hartmann, D.2    Sievers, J.3
  • 201
    • 80055014830 scopus 로고    scopus 로고
    • Central nervous system pericytes in health and disease
    • Winkler E.A., Bell R.D., Ziokovic B.V. Central nervous system pericytes in health and disease. Nat Neurosci 2011, 14:1398-1405.
    • (2011) Nat Neurosci , vol.14 , pp. 1398-1405
    • Winkler, E.A.1    Bell, R.D.2    Ziokovic, B.V.3
  • 202
    • 0028219403 scopus 로고
    • Down-regulation of membrane glycoprotein in amoeboid microglia transforming into ramified microglia in postnatal rat brain
    • Wu C.H., Wen C.Y., Shieh J.Y., Ling E.A. Down-regulation of membrane glycoprotein in amoeboid microglia transforming into ramified microglia in postnatal rat brain. J Neurocytol 1994, 23:258-269.
    • (1994) J Neurocytol , vol.23 , pp. 258-269
    • Wu, C.H.1    Wen, C.Y.2    Shieh, J.Y.3    Ling, E.A.4
  • 203
    • 0037947448 scopus 로고    scopus 로고
    • NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    • Wu D.C., Teismann P., Tieu K., Vila M., Jackson-Lewis V., Ischiropoulos H., et al. NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Proc Natl Acad Sci USA 2003, 100:6145-6150.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6145-6150
    • Wu, D.C.1    Teismann, P.2    Tieu, K.3    Vila, M.4    Jackson-Lewis, V.5    Ischiropoulos, H.6
  • 204
    • 20144389524 scopus 로고    scopus 로고
    • Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease
    • Zhang W., Wang T., Pei Z., Miller D.S., Wu X., Block M.L., et al. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J 2005, 19:533-542.
    • (2005) FASEB J , vol.19 , pp. 533-542
    • Zhang, W.1    Wang, T.2    Pei, Z.3    Miller, D.S.4    Wu, X.5    Block, M.L.6
  • 205
    • 77954217806 scopus 로고    scopus 로고
    • The direction of synaptic plasticity mediated by C-fibers in spinal dorsal horn is decided by Src-family kinases in microglia: the role of tumor necrosis factor-alpha
    • Zhong Y., Zhou L.J., Ren W.J., Xin W.J., Li Y.Y., Zhang T., et al. The direction of synaptic plasticity mediated by C-fibers in spinal dorsal horn is decided by Src-family kinases in microglia: the role of tumor necrosis factor-alpha. Brain Behav Immun 2010, 24:874-880.
    • (2010) Brain Behav Immun , vol.24 , pp. 874-880
    • Zhong, Y.1    Zhou, L.J.2    Ren, W.J.3    Xin, W.J.4    Li, Y.Y.5    Zhang, T.6


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