Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease

International Journal of Neuropsychopharmacology

Volumn 15, Issue 1, 2012, Pages 77-90

  Chen, Chia Hsiung ^a   Zhou, Weihui ^a,b   Liu, Shengchun ^a,b   Deng, Yu ^a   Cai, Fang ^a   Tone, Masahide ^c   Tone, Yukiko ^c   Tong, Yigang ^a   Song, Weihong ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b CHONGQING MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Amyloid precursor protein (APP); site APP cleaving enzyme 1 (BACE1); Alzheimer's disease; amyloid protein (A ); NF B; NSAIDs

Indexed keywords

ACETYLSALICYLIC ACID; BETA SECRETASE 1; I KAPPA B; IBUPROFEN; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APP PROTEIN, HUMAN; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; SECRETASE; TRANSCRIPTION FACTOR RELA;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME BLOOD LEVEL; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SYSTEMATIC REVIEW; TRANSCRIPTION INITIATION; UPREGULATION; AGED; BRAIN; DRUG EFFECTS; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PROMOTER REGION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPARTIC ACID ENDOPEPTIDASES; BRAIN; HUMANS; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84856428468     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145711000149     Document Type: Article

References (41)

1. Baeuerle PA, Henkel T (1994). Function and activation of NF-kappa B in the immune system. Annual Review of Immunology 12, 141-179.
2. Baldwin AS (1996). The NF-kappa B and I kappa B proteins : new discoveries and insights. Annual Review of Immunology 14, 649-683.
3. Barger SW, Horster D, Furukawa K, Goodman Y, et al. (1995). Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity : evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation. Proceedings of the National Academy of Sciences USA 92, 9328-9332.
4. Behl C, Davis JB, Lesley R, Schubert D (1994). Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77, 817-827. (Pubitemid 24187680)
5. Blasko I, Apochal A, Boeck G, Hartmann T, et al. (2001). Ibuprofen decreases cytokine-induced amyloid beta production in neuronal cells. Neurobiology of Disease 8, 1094-1101. (Pubitemid 34017102)
6. Bourne KZ, Ferrari DC, Lange-Dohna C, Rossner S, et al. (2007). Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides. Journal of Neuroscience Research 85, 1194-1204. (Pubitemid 46724363)
7. Buggia-Prevot V, Sevalle J, Rossner S, Checler F (2008). NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42. Journal of Biological Chemistry 283, 10037-10047.
8. Cai F, Chen B, Zhou W, Zis O, et al. (2008). SP1 regulates a human SNAP-25 gene expression. Journal of Neurochemistry 105, 512-523. (Pubitemid 351490021)
9. Christensen MA, Zhou W, Qing H, Lehman A, et al. (2004). Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1. Molecular and Cellular Biology 24, 865-874. (Pubitemid 38057936)
10. De Pietri Tonelli D, Mihailovich M, Di Cesare A, Codazzi F, et al. (2004). Translational regulation of BACE-1 expression in neuronal and non-neuronal cells. Nucleic Acids Research 32, 1808-1817. (Pubitemid 38832726)
11. Gapuzan ME, Schmah O, Pollock AD, Hoffmann A, et al. (2005). Immortalized fibroblasts from NF-kappaB RelA knockout mice show phenotypic heterogeneity and maintain increased sensitivity to tumor necrosis factor alpha after transformation by v-Ras. Oncogene 24, 6574-6583. (Pubitemid 41486640)
12. Ghosh S, May MJ, Kopp EB (1998). NF-kappa B and Rel proteins : evolutionarily conserved mediators of immune responses. Annual Review of Immunology 16, 225-260. (Pubitemid 28183365)
13. Guo Q, Robinson N, Mattson MP (1998). Secreted betaamyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis. Journal of Biological Chemistry 273, 12341-12351. (Pubitemid 28240603)
14. Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, et al. (1997). Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proceedings of the National Academy of Sciences USA 94, 2642-2647. (Pubitemid 27136929)
15. Kitamura Y, Shimohama S, Ota T, Matsuoka Y, et al. (1997). Alteration of transcription factors NF-kappaB and STAT1 in Alzheimer's disease brains. Neuroscience Letters 237, 17-20. (Pubitemid 27521155)
16. Lammich S, Schobel S, Zimmer AK, Lichtenthaler SF, et al. (2004). Expression of the Alzheimer protease BACE1 is suppressed via its 5k-untranslated region. EMBO Reports 5, 620-625. (Pubitemid 39139534)
17. Li Y, Zhou W, Tong Y, He G, et al. (2006). Control of APP processing and Abeta generation level by BACE1 enzymatic activity and transcription. FASEB Journal 20, 285-292. (Pubitemid 44933176)
18. Miyamoto S, Verma IM (1995). Rel/NF-kappa B/I kappa B story. Advances in Cancer Research 66, 255-292.
19. Qing H, Zhou W, Christensen MA, Sun X, et al. (2004). Degradation of BACE by the ubiquitin-proteasome pathway. FASEB Journal 18, 1571-1573. (Pubitemid 39561636)
20. Rogers GW, Edelman GM, Mauro VP (2004). Differential utilization of upstream AUGs in the beta-secretase mRNA suggests that a shunting mechanism regulates translation. Proceedings of the National Academy of Sciences USA 101, 2794-2799. (Pubitemid 38327690)
21. Saille C, Marin P, Martinou JC, Nicole A, et al. (1999). Transgenic murine cortical neurons expressing human Bcl-2 exhibit increased resistance to amyloid beta-peptide neurotoxicity. Neuroscience 92, 1455-1463. (Pubitemid 29292580)
22. Sastre M, Dewachter I, Rossner S, Bogdanovic N, et al. (2006). Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proceedings of the National Academy of Sciences USA 103, 443-448. (Pubitemid 43122420)
23. Schreck R, Albermann K, Baeuerle PA (1992). Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radical Research Communications 17, 221-237. (Pubitemid 23207431)
24. Schreck R, Rieber P, Baeuerle PA (1991). Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO Journal 10, 2247-2258. (Pubitemid 21905698)
25. Siebenlist U, Franzoso G, Brown K (1994). Structure, regulation and function of NF-kappa B. Annual Review of Cell Biology 10, 405-455.
26. Stockley JH, O'Neill C (2007). The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain. Biochemical Society Transactions 35, 574-576. (Pubitemid 46975079)
27. Sun X, He G, Qing H, Zhou W, et al. (2006a). Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression. Proceedings of the National Academy of Sciences USA 103, 18727-18732. (Pubitemid 44913478)
28. Sun X, He G, Song W (2006b). BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome. FASEB Journal 20, 1369-1376. (Pubitemid 44943845)
29. Sun X, Tong Y, Qing H, Chen CH, et al. (2006c). Increased BACE1 maturation contributes to the pathogenesis of Alzheimer's disease in Down syndrome. FASEB Journal 20, 1361-1368. (Pubitemid 44943844)
30. Sun X, Wang Y, Qing H, Christensen MA, et al. (2005). Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes. FASEB Journal 19, 739-749. (Pubitemid 40617378)
31. Terai K, Matsuo A, McGeer PL (1996). Enhancement of immunoreactivity for NF-kappa B in the hippocampal formation and cerebral cortex of Alzheimer's disease. Brain Research 735, 159-168. (Pubitemid 26336632)
32. Tesco G, Koh YH, Kang EL, Cameron AN, et al. (2007). Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron 54, 721-737. (Pubitemid 46843521)
33. Tone M, Tone Y, Babik JM, Lin CY, et al. (2002). The role of Sp1 and NF-kappa B in regulating CD40 gene expression. Journal of Biological Chemistry 277, 8890-8897. (Pubitemid 34952958)
34. Tong Y, Zhou W, Fung V, Christensen MA, et al. (2005). Oxidative stress potentiates BACE1 gene expression and Abeta generation. Journal of Neural Transmission 112, 455-469. (Pubitemid 40868054)
35. Vinet J, Bernier PJ, Parent A (2002). Bcl-2 expression in thalamus, brainstem, cerebellum and visual cortex of adult primate. Neuroscience Research 42, 269-277. (Pubitemid 34414987)
36. Wang W-X, Rajeev BW, Stromberg AJ, Ren N, et al. (2008). The expression of MicroRNA miR-107 decreases early in Alzheimer's disease and May accelerate disease progression through regulation of {beta}-site amyloid precursor protein-cleaving enzyme 1. Journal of Neuroscience 28, 1213-1223. (Pubitemid 351186356)
37. Weggen S, Eriksen JL, Das P, Sagi SA, et al. (2001). A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 414, 212-216. (Pubitemid 33051236)
38. Wen Y, Yu WH, Maloney B, Bailey J, et al. (2008). Transcriptional regulation of [beta]-secretase by p25/cdk5 leads to enhanced amyloidogenic processing. Neuron 57, 680-690. (Pubitemid 351335351)
39. Yankner BA, Duffy LK, Kirschner DA (1990). Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science 250, 279-282.
40. Zhao J, Fu Y, Yasvoina M, Shao P, et al. (2007). Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis. Journal of Neuroscience 27, 3639-3649. (Pubitemid 46557686)
41. Zhou W, Song W (2006). Leaky scanning and reinitiation regulate BACE1 gene expression. Molecular and Cellular Biology 26, 3353-3364.