Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations

Journal of Biological Chemistry

Volumn 287, Issue 29, 2012, Pages 24573-24584

  Chami, Linda ^a   Buggia Prévot, Virginie ^a,c   Duplan, Eric ^a   Delprete, Dolores ^a   Chami, Mounia ^a   Peyron, Jean François ^b   Checler, Frédéric ^a  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b CENTRE MÉDITERRANÉEN DE MÉDECINE MOLÉCULAIRE C3M   (France)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER; AMYLOID PRECURSOR PROTEINS; ENZYMATIC ACTIVITIES; EXPERIMENTAL CONDITIONS; HEK293 CELLS; INTRACELLULAR DOMAIN; NICASTRIN; NUCLEAR FACTORS; PATHOLOGICAL CONDITIONS; PHYSIOLOGICAL CONDITION; PROTEIN COMPONENTS; PROTEIN EXPRESSIONS; PROTEIN LEVEL; SECRETASES; SENILE PLAQUES; TRANSCRIPTIONAL ACTIVITY;

ENZYMES; GLYCOPROTEINS; PEPTIDES; TRANSCRIPTION FACTORS;

PHYSIOLOGY;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; BETA SECRETASE; BETA SECRETASE 1; CELL PROTEIN; GAMMA SECRETASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NICASTRIN; PRESENILIN 1; PRESENILIN 2; PROTEIN PEN 2; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HOMEOSTASIS; PROTEIN SYNTHESIS INHIBITION; PROTEIN SYNTHESIS REGULATION; SIGNAL TRANSDUCTION; STABLE TRANSFECTION; TRANSCRIPTION REGULATION;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; BLOTTING, WESTERN; CELL LINE; GENE EXPRESSION; HUMANS; MEMBRANE GLYCOPROTEINS; NF-KAPPA B; PROMOTER REGIONS, GENETIC;

EID: 84863798868     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.333054     Document Type: Article

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