Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an alzheimer's mouse model

Journal of Neuroscience

Volumn 33, Issue 11, 2013, Pages 5053-5064

  Ghosh, Simantini ^a   Wu, Michael D ^a   Shaftel, Solomon S ^a   Kyrkanides, Stephanos ^b   LaFerla, Frank M ^c   Olschowka, John A ^a   Kerry O'Banion, M ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; GLYCOGEN SYNTHASE KINASE 3BETA; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE P38; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRANSGENIC MOUSE; WESTERN BLOTTING;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANALYSIS OF VARIANCE; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMMUNODEFICIENCY VIRUS, FELINE; INTERLEUKIN-1BETA; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICROFILAMENT PROTEINS; MUSCLE PROTEINS; MUTATION; PRESENILIN-1; TAU PROTEINS; TRISACCHARIDES; TUBULIN;

EID: 84874882726     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4361-12.2013     Document Type: Article

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