Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: Possibilities for therapeutic intervention

Oncotarget

Volumn 5, Issue 13, 2014, Pages 4603-4650

  Davis, Nicole M ^a   Sokolosky, Melissa ^a   Stadelman, Kristin ^a   Abrams, Steve L ^a   Libra, Massimo ^b   Candido, Saverio ^b   Nicoletti, Ferdinando ^b   Polesel, Jerry ^c   Maestro, Roberta ^c   D'Assoro, Antonino ^d   Drobot, Lyudmyla ^e   Rakus, Dariusz ^f   Gizak, Agnieszka ^f   Laidler, Piotr ^g   Dulinska Litewka, Joanna ^g   Basecke, Joerg ^h   Mijatovic, Sanja ⁱ   Maksimovic Ivanic, Danijela ⁱ   Montalto, Giuseppe ^j,k   Cervello, Melchiorre ^k   Fitzgerald, Timothy L ^a   Demidenko, Zoya N ^l   Martelli, Alberto M ^m   Cocco, Lucio ^m   Steelman, Linda S ^a   McCubrey, James A ^a   more..

^a EAST CAROLINA UNIVERSITY   (United States)

^b UNIVERSITY OF CATANIA   (Italy)

^c CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^d MAYO GRADUATE SCHOOL   (United States)

^e PALLADIN INSTITUTE OF BIOCHEMISTRY   (Ukraine)

^f UNIVERSITY OF WROC AW   (Poland)

^g JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^h UNIVERSITY OF GÖTTINGEN   (Germany)

ⁱ UNIVERSITY OF BELGRADE   (Serbia)

^j UNIVERSITY OF PALERMO   (Italy)

^k CNR   (Italy)

^l ROSWELL PARK CANCER INSTITUTE   (United States)

^m UNIVERSITY OF BOLOGNA   (Italy)

more..

Author keywords

MTOR; Mutations; PI3K; Rapamycin; Targeted therapy; Therapy resistance

Indexed keywords

ANTINEOPLASTIC AGENT; AZD 6482; BUPARLISIB; CETUXIMAB; CYCLOPHOSPHAMIDE; DACTOLISIB; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; FULVESTRANT; GSK 2636771; HYDROXYUREA; LAPATINIB; LETROZOLE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOXANTRONE; NERATINIB; PACLITAXEL; PHENMETRAZINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PICTILISIB; PILARALISIB; PROTEIN KINASE B; RAPAMYCIN; TEMSIROLIMUS; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; PIK3CA PROTEIN, HUMAN; PTEN PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER COMBINATION CHEMOTHERAPY; CANCER HORMONE THERAPY; CANCER INITIATING CELL; CANCER RADIOTHERAPY; CANCER SURGERY; DNA REPAIR; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG RESISTANCE; DRUG SENSITIVITY; DRUG TARGETING; ENDOMETRIUM CANCER; EPIGENETICS; EPITHELIAL MESENCHYMAL TRANSITION; GENE; GENE AMPLIFICATION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HER2 GENE; HEREDITARY BREAST AND OVARIAN CANCER SYNDROME; HUMAN; METASTASIS; MONOTHERAPY; NONHUMAN; ONCOGENE C MYC; ONCOGENE RAS; PIK3CA GENE; PROTEIN PROTEIN INTERACTION; RNA SPLICING; SIGNAL TRANSDUCTION; TRANSLATION REGULATION; TUMOR SUPPRESSOR GENE; BREAST TUMOR; FEMALE; GENE EXPRESSION REGULATION; GENETICS;

BREAST NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MULTIPROTEIN COMPLEXES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84904968175     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2209     Document Type: Article

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