Bid as a potential target of apoptotic effects exerted by low doses of PPARγ and RXR ligands in breast cancer cells

Cell Cycle

Volumn 10, Issue 14, 2011, Pages 2344-2354

  Bonofiglio, Daniela ^a   Cione, Erika ^a   Vizza, Donatella ^a   Perri, Mariarita ^a   Pingitore, Attilio ^a   Qi, Hongyan ^a   Catalano, Stefania ^a   Rovito, Daniela ^a   Genchi, Giuseppe ^a   Andò, Sebastiano ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

Author keywords

Apoptosis; Bid; Breast cancer; Mitochondria; PPAR ; RXR

Indexed keywords

GLUTATHIONE TRANSFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN BCL 2; PROTEIN BID; PROTEIN P21; PROTEIN P53; RETINOID X RECEPTOR; ROSIGLITAZONE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL GROWTH; ENZYME ACTIVITY; ENZYME INDUCTION; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENE SEQUENCE; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LIPID PEROXIDATION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSIENT TRANSFECTION; UPREGULATION; WESTERN BLOTTING;

EID: 79960453436     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.14.15917     Document Type: Article

References (33)

1. Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML, et al. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 1993; 362:849-52. (Pubitemid 23132162)
2. Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 1993; 362:847-9. (Pubitemid 23132161)
3. Lowe SW, Bodis S, McClatchey A, Remington L, Ruley HE, Fisher DE, et al. p53 status and the efficacy of cancer therapy in vivo. Science 1994; 266:807-10. (Pubitemid 24359290)
4. El-Deiry WS. Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling. Cell Death Differ 2001; 8:1066-75. (Pubitemid 33061824)
5. Caelles C, Helmberg A, Karin M. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 1994; 370:220-3. (Pubitemid 24236778)
6. Haupt Y, Rowan S, Shaulian E, Vousden KH, Oren M. Induction of apoptosis in HeLa cells by transactivation-deficient p53. Genes Dev 1995; 9:2170-83.
7. Ding HF, Lin YL, McGill G, Juo P, Zhu H, Blenis J, et al. Essential role for caspase-8 in transcription-independent apoptosis triggered by p53. J Biol Chem 2000; 275:38905-11. (Pubitemid 32009229)
8. Chipuk JE, Maurer U, Green DR, Schuler M. Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription. Cancer Cell 2003; 4:371-81. (Pubitemid 37491098)
9. Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 2004; 303:1010-4. (Pubitemid 38209704)
10. Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, et al. Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death. Science 2001; 292:727-30. (Pubitemid 32385543)
11. Wei MC, Lindsten T, Mootha VK, Weiler S, Gross A, Ashiya M, et al. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev 2000; 14:2060-71. (Pubitemid 30637355)
12. Korsmeyer SJ, Wei MC, Saito M, Weiler S, Oh KJ, Schlesinger PH. Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ 2000; 7:1166-73. (Pubitemid 32042223)
13. Bonofiglio D, Cione E, Qi H, Pingitore A, Perri M, Catalano S, et al. Combined low doses of PPARgamma and RXR ligands trigger an intrinsic apoptotic pathway in human breast cancer cells. Am J Pathol 2009; 175:1270-80.
14. Levine AJ. p53, the cellular gatekeeper for growth and division. Cell 1997; 88:323-31.
15. Hansen R, Oren M. p53; from inductive signal to cellular effect. Curr Opin Genet Dev 1997; 7:46-51. (Pubitemid 27092763)
16. Oren M. Regulation of the p53 tumor suppressor protein. J Biol Chem 1999; 274:36031-4.
17. Chung SH, Onoda N, Ishikawa T, Ogisawa K, Takenaka C, Yano Y, et al. Peroxisome proliferator-activated receptor gamma activition induce cell cycle arrest via p53-independent pathway in human anaplastic thyroid cancer cells. Jap J Cancer Res 2002; 93:1358-65. (Pubitemid 36104876)
18. Hong J, Samudio I, Liu S, Abdelrahim M, Safe S. Peroxisome proliferator-activited receptor γ-dependent activation of p21 in panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins. Endocrinology 2004; 145:5774-85. (Pubitemid 39564619)
19. Cip/WAF1 in a Sp1-dependent manner. Endocr Relat Cancer 2008; 15:545-57.
20. Murphy ME, Leu JIJ, George DL. p53 moves to mitochondria. A turn on the path to apoptosis. Cell Cycle 2004; 3:836-9.
21. Bonofiglio D, Aquila S, Catalano S, Gabriele S, Belmonte M, Middea E, et al. Peroxisome proliferator-activated receptor-gamma activates p53 gene promoter binding to the nuclear factor-kappaB sequence in human MCF7 breast cancer cells. Mol Endocrinol 2006; 20:3083-92. (Pubitemid 44833557)
22. Marchenko ND, Zaika A, Moll UM. Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling. J Biol Chem 2000; 275:16202-12. (Pubitemid 30366932)
23. Katsumoto T, Higaki K, Ohno K, Onodera K. Cell cycle dependent biosynthesis and localization of p53 protein in untransformed human cells. Biol Cell 1995; 84:167-73. (Pubitemid 26017544)
24. Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, et al. p53 has a direct apoptogenic role at the mitochondria. Mol Cell 2003; 11:577-90. (Pubitemid 36385115)
25. Jiang P, Du WJ, Heese K, Wu M. The Bad Guy Cooperates with Good Cop p53: Bad is transcriptionally upregulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis. Mol Cell Biol 2006; 26:9071-82. (Pubitemid 44851962)
26. Song G, Chen GG, Yun JP, Lai PB. Association of p53 with Bid induces cell death in response to etoposide treatment in hepatocellular carcinoma. Curr Cancer Drug Targets 2009; 9:871-80.
27. Sax JK, Fei P, Murphy ME, Bernhard E, Korsmeyer SJ, El-Deiry WS. BID regulation by p53 contributes to chemosensitivity. Nat Cell Biol 2002; 4:842-9. (Pubitemid 35331358)
28. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 1998; 281:1322-6. (Pubitemid 28406819)
29. Gross A, McDonnell JM, Korsmeyer SJ. BCL-2 family members and the mitochondria in apoptosis. Genes Dev 1999; 13:1899-911. (Pubitemid 29407357)
30. Pelicano H, Carney D, Huang P. ROS stress in cancer cells and therapeutic implications. Drug Resistance Updates 2004; 7:97-110. (Pubitemid 38736063)
31. Simon HU, Haj-Yehia A, Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 2000; 5:415-8. (Pubitemid 32162623)
32. Fruehauf JP, Meyskens FL Jr. Reactive oxygen species: A breath of life or death? Clin Cancer Res 2007; 13:789-94.
33. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95:351-8. (Pubitemid 9194347)