Harnessing the PI3K/Akt/mtor pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels

Oncotarget

Volumn 3, Issue 8, 2012, Pages 811-823

  Bressanin, Daniela ^a   Evangelisti, Camilla ^b   Ricci, Francesca ^c   Tabellini, Giovanna ^d   Chiarini, Francesca ^b   Tazzari, Pier Luigi ^c   Melchionda, Fraia ^a   Buontempo, Francesca ^a   Pagliaro, Pasqualepaolo ^c   Pession, Andrea ^a   McCubrey, James A ^e   Martelli, Alberto M ^a,b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d UNIVERSITY OF BRESCIA   (Italy)

^e EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Acute leukemia; PI3K PDK1; Signal transduction modulators; Targeted therapy; Vertical inhibition

Indexed keywords

8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; ANTINEOPLASTIC AGENT; CASPASE 3; EVEROLIMUS; KU 63794; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; NVP BAG 956; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PICTILISIB; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; ENZYME INHIBITION; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; INTRACELLULAR SIGNALING; PROTEIN CLEAVAGE; SURVIVAL RATE;

EID: 84868614691     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.579     Document Type: Article

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