Expression and promoter methylation of the RASSF1A gene in sporadic breast cancers in Chinese women

Oncology Reports

Volumn 19, Issue 5, 2008, Pages 1149-1153

  Li, Yongmei ^a   Wei, Qinjun ^a   Cao, Fang ^a   Cao, Xin ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

MSP, methylated specific PCR; RASSF1, Ras association domain family 1

Indexed keywords

MESSENGER RNA; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; RASSF1 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER TISSUE; CHINESE; CLINICAL ARTICLE; COLLOID CARCINOMA; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG CARCINOMA; LYMPH NODE METASTASIS; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; TISSUE DIFFERENTIATION; BIOSYNTHESIS; BREAST TUMOR; CHINA; ETHNOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; METASTASIS; MOLECULAR GENETICS;

BASE SEQUENCE; BREAST NEOPLASMS; CHINA; CPG ISLANDS; DNA METHYLATION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LYMPHATIC METASTASIS; MOLECULAR SEQUENCE DATA; NEOPLASM METASTASIS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; TUMOR SUPPRESSOR PROTEINS;

EID: 47549107706     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: 10.3892/or.19.5.1149     Document Type: Article

References (23)

1. Dammann R, Li C, Yoon JH, Chin PL, Bates S and Pfeifer GP: Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat Genet 25: 315-319, 2000.
2. Dammann R, Yang G and Pfeifer GP: Hypermethylation of the CpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers. Cancer Res 61: 3105-3109, 2001.
3. Burbee DG, Forgacs E, Zöchbauer-Müller S, Shivakumar L, Fong K, Gao B, Randle D, Kondo M, Virmani A, Bader S, Sekido Y, Latif F, Milchgrub S, Toyooka S, Gazdar AF, Lerman MI, Zabarovsky E, White M and Minna JD: Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. J Natl Cancer Inst 93: 664-665, 2001.
4. Whang YM, Kim YH, Kim JS and Yoo DY: RASSF1A suppresses the c-Jun-NH2-kinase pathway and inhibits cell cycle progression. Cancer Res 65: 3682-3690, 2005.
5. Honorio S, Agathanggelou A, Schuermann M, Pankow W, Viacava P, Maher ER and Latif F: Detection of RASSF1A aberrant promoter hypermethylation in sputum from chronic smokers and ductal carcinoma in situ from breast cancer patients. Oncogene 22: 147-150, 2003.
6. Tommasi S, Danimann R, Zhang Z, Wang Y, Liu L, Tsark WM, Wilczynski SP, Li J, You M and Pfeifer GP: Tumor susceptibility of Rassf1a knockout mice. Cancer Res 65: 92-98, 2005.
7. Burbee DG, Forgacs E and Zöchbauer-Müller S: Epigenetic inactivation of RASSF1A in lung and breast cancers malignant phenotype suppression. J Natl Cancer Inst 93: 691-699, 2001.
8. Dammann R, Takahashi T and Pfeifer GP: The CpG island of the novel tumor suppressor gene RASSF1A is intensely methylated in primary small cell lung carcinomas. Oncogene 20: 3563-3567, 2000.
9. Agathanggelou A, Cooper WN and Latif F: Role of the Rasassociation domain family 1 tumor suppressor gene in human cancers. Cancer Res 65: 3497-3508, 2005.
10. Agathanggelou A, Honorio S, Macartney DP, Martinez A, Dallol A, Rader J, Fullwood P, Chauhan A, Walker R, Shaw JA, Hosoe S, Lerman MI, Minna JD, Maher ER and Latif F: Methylation-associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumors. Oncogene 20: 1509-1518, 2001.
11. Yan PS, Shi H, Rahmatpanah F, Hsiau THC, Hsiau AHA, Len YW, Liu JC and Huang THM: Differential distribution of DNA methylation within the RASSF1A CpG island in breast cancer. Cancer Res 63: 6178-6186, 2003.
12. Shinozaki M, Hoon DS, Giuliano AE, Hansen NM, Wang HJ, Turner R and Taback B: Distinct hypermethylation profile of primary breast cancer is associated with sentinel lymph node metastasis. Clin Cancer Res 11: 2156-2162, 2005.
13. Geng C, Li X, Li Y, Shan B, Chen J, Fan Z and Wan S: Clinic pathologic significance of RASSF1A expression in human breast carcinoma. Chin J Cancer Prev Treat 13P: 1631-1634, 2006.
14. Herman JG, Graff JR, Myohanen S, Nelkin BD and Baylin SB: Methylation-specific PCR:A novel PCR assay for methylation status of CpG island. Proc Natl Acad Sci USA 93: 9821-9826, 1996.
15. Sasaki M, Anast J, Bassett W, Kawakami T, Sakuragi N and Dahiya R: Bisulfite conversion-specific and methylation-specific PCR: a sensitive technique for accurate evaluation of CpG methylation. Biochem Biophys Res Commun 309: 305-309, 2003.
16. Jones PA and Takai D: The role of DNA methylation in mammalian epigenetics. Science 293: 1068-1070, 2001.
17. Herman JG and Baylin SB: Gene silencing in cancer in association with promoter methylation. N Engl J Med 349: 2042-2054, 2003.
18. Schagdarsurengin U, Wilkens L, Steinemann D, Flemming P, Kreipe HH, Pfeifer GP, Schlegelberger B and Dammann R: Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma. Oncogene 22: 1866-1871, 2003.
19. Zhong S, Yeo W, Tang MW, Wong N, Lai PB and Johnson PJ: Intensive hypermethylation of the CpG island of Ras association domain family 1A in hepatitis B virus-associated hepatocellular carcinomas. Clin Cancer Res 9: 3376-3382, 2003.
20. Lehmann U, Wingen LU, Brakensiek K, Wedemeyer H, Becker T, Heim A, Metzig K, Hasemeier B, Kreipe H and Flemming P: Epigenetic defects of hepatocellular carcinoma are already found in non-neoplastic liver cells from patients with hereditary haemochromatosis. Hum Mol Genet 16: 1335-1342, 2007.
21. Liu L, Yoon JH, Dammann R and Pfeifer GP: Frequent hypermethylation of the RASSF1A gene in prostate cancer. Oncogene 21: 6835-6840, 2002.
22. Kuzmin I, Gillespie JW, Protopopov A, Geil L, Dreijerink K, Yang Y, Vocke CD, Duh FM, Zabarovsky E, Minna JD, Rhim JS, Emmert-Buck MR, Linehan WM and Lerman MI: The RASSF1A tumor suppressor gene is inactivated in prostate tumors and suppresses growth of prostate carcinoma cells. Cancer Res 62: 3498-3502, 2002.
23. Lee JS, Lo PK, Fackler MJ, Argani P, Zhang Z, Garrett-Mayer E and Sukumar SA: Comparative study of Korean with Caucasian breast cancer reveals frequency of methylation in multiple genes correlates with breast cancer in young, ER, PR-negative breast cancer in Korean women. Cancer Biol Ther 6: 1114-1120, 2007.