Role of the raf signal transduction cascade in the in vitro resistance to the anticancer drug doxorubicin

Clinical Cancer Research

Volumn 7, Issue 9, 2001, Pages 2898-2907

  Weinstein Oppenheimer, Caroline R ^a,b   Davis, Julianne M ^a   Navolanic, Patrick M ^a   Saleh, Oussama A ^a   Steelman, Linda S ^a   Franklin, Richard A ^a   Robinson, Penni J ^a   McCubrey, James A ^a   Henríquez Roldán, Carlos F ^c,d   McMahon, Martin ^e  

^a EAST CAROLINA UNIVERSITY   (United States)

^b Instituto de Biometría   (Germany)

^c Universidad de Valpara so   (United States)

^d IL   (United States)

^e MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; RAF PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER; CANCER CHEMOTHERAPY; GROWTH RATE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTO ONCOGENE; SIGNAL TRANSDUCTION;

ANNEXIN A5; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DIVISION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; MICROSCOPY, CONFOCAL; PLASMIDS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-RAF; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TESTOSTERONE; TUMOR CELLS, CULTURED;

EID: 0034808394     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Drug resistance, the last frontier?
2. The biology of radioresistance: Similarities, differences and interactions with drug resistance
3. Anticancer drug resistance and inhibition of apoptosis
4. Apoptosis and cancer chemotherapy
5. Molecular mechanisms of drug resistance in tumors
6. BCL-2: Prevention of apoptosis as a mechanism of drug resistance
7. Bcl-2 family proteins: Regulators of apoptosis and chemoresistance in hematologic malignancies
8. L expression in human sensitive and resistant leukemia
9. Novel mechanisms of drug resistance in leukemia
10. Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB
11. Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: Possible sites for intervention with anti-neoplastic drugs
12. The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors
13. Effects of the activated Raf protein kinase on the human multidrug resistance 1 (MDRI) gene promoter
14. A signal transduction pathway for activation of the mdrI promoter involves the proto-oncogene c-raf kinase
15. High Raf-1 kinase activity protects human tumor cells against paclitaxel-induced cytotoxicity
16. Oncogenic effects of overexpression of the interleukin-3 receptor on hematopoietic cells
17. Abrogation of factor-dependence in 2 IL-3-dependent cell lines can occur by two distinct mechanisms
18. Retroviral infection can abrogate the factor-dependency of hematopoietic cells by autocrine and non-autocrine mechanisms depending on the presence of a functional viral oncogene
19. Differential effects of viral and cellular oncogenes on the growth factor-dependency of hematopoietic cells
20. Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase
21. Synergism of v-myc and v-Ha-ras in the in vitro neoplastic progression of murine lymphoid cells
22. Cip1
23. New colorimetric cytotoxicity assay for anticancer drug-screening
24. 50 and its confidence intervals when subtoxic stimulus is present
25. Cell line designation change: Multidrug-resistant cell line in the NCI anticancer screen
26. Differential abilities of activated Raf oncoproteins to abrogate cytokine-dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells
27. Differential abilities of protein kinases to abrogate cytokine-dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism
28. Abrogation of c-Raf-1 expression induces apoptosis in tumor cells
29. A conditionally-active form of MEK1 abrogates cytokine-dependency in human and mouse hematopoietic cells
30. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
31. Alteration of caspase-3 (CPP32/Yama/apopain) in wild-type MCF-7, breast cancer cells