Mutation profiling identifies numerous rare drug targets and distinct mutation patterns in different clinical subtypes of breast cancers

Breast Cancer Research and Treatment

Volumn 134, Issue 1, 2012, Pages 333-343

  Santarpia, Libero ^a,b   Qi, Yuan ^b   Stemke Hale, Katherine ^b   Wang, Bailiang ^b   Young, Elliana J ^b   Booser, Daniel J ^b   Holmes, Frankie A ^c   O'Shaughnessy, Joyce ^c,d   Hellerstedt, Beth ^d   Pippen, John ^c,d   Vidaurre, Tatiana ^e   Gomez, Henry ^e   Valero, Vicente ^b   Hortobagyi, Gabriel N ^b   Symmans, W Fraser ^b   Bottai, Giulia ^a   Di Leo, Angelo ^a   Gonzalez Angulo, Ana M ^b   Pusztai, Lajos ^b  

^a ISTITUTO TOSCANO TUMORI   (Italy)

^b UNIVERSITY OF TEXAS   (United States)

^c Developmental Therapeutics Committee and Co Chair of the Genitourinary Committee   (United States)

^d TEXAS ONCOLOGY   (United States)

^e INSTITUTO NACIONAL DE ENFERMEDADES NEOPLÁSICAS   (Peru)

Author keywords

Breast cancer; Drug targets; Gene mutations; Mutation detection; Signaling pathways

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; 4 [BIS(2 CHLOROETHYL)OXIDOAMINO]PHENYLALANINE; 5 (6 QUINOXALINYLMETHYLENE) 2,4 THIAZOLIDINEDIONE; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; AG 18; ANTINEOPLASTIC AGENT; AVN 316; AXITINIB; CABOZANTINIB; DANUSERTIB; ESTROGEN RECEPTOR; EVEROLIMUS; IMATINIB; MOTESANIB; NILOTINIB; ORANTINIB; PICTRELISIB; PIMASERTIB; PONATINIB; RAPAMYCIN; RX 0047; SELUMETINIB; SORAFENIB; TANDUTINIB; TEMSIROLIMUS; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; XL 147; [1 (4 OXO 8 PHENYL 4H 1 BENZOPYRAN 2 YL)MORPHOLINIO]METHOXYSUCCINYLARGINYLGLYCYLASPARTYLSERINE ACETATE;

ADULT; AGED; AKT GENE; AKT1 GENE; ALLELE; ARTICLE; ASPIRATION BIOPSY; BRAF GENE; BREAST CANCER; CANCER CELL; CANCER STAGING; CONTROLLED STUDY; CTNNB1 GENE; DISEASE CLASSIFICATION; DNA POLYMORPHISM; DRUG TARGETING; EGFR GENE; FBXW7 GENE; FEMALE; GENE; GENE ACTIVATION; GENE EXPRESSION PROFILING; GENE FREQUENCY; GENE IDENTIFICATION; GENE MUTATION; GENE SEQUENCE; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; KIT GENE; KRAS GENE; MAJOR CLINICAL STUDY; PDGFR ALPHA GENE; PHLPP2 GENE; PIK3CA GENE; PRIORITY JOURNAL; TRIPLE NEGATIVE BREAST CANCER; VALIDATION STUDY;

EID: 84863983915     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-012-2035-3     Document Type: Article

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