-
1
-
-
0037048290
-
Roles of BRCA1 in centrosome duplication
-
Deng C.X. Roles of BRCA1 in centrosome duplication. Oncogene. 21:2002;6222-6227.
-
(2002)
Oncogene
, vol.21
, pp. 6222-6227
-
-
Deng, C.X.1
-
2
-
-
0035502955
-
Identification of a gamma-tubulin-binding domain in BRCA1
-
Hsu L.C., Doan T.P., White R.L. Identification of a gamma-tubulin-binding domain in BRCA1. Cancer Res. 61:2001;7713-7718.
-
(2001)
Cancer Res.
, vol.61
, pp. 7713-7718
-
-
Hsu, L.C.1
Doan, T.P.2
White, R.L.3
-
3
-
-
0036836565
-
Subcellular localization of the BRCA1 gene product in mitotic cells
-
Lotti L.V., Ottini L., D'Amico C., Gradini R., Cama A., Belleudi F., Frati L., Torrisi M.R., Mariani-Costantini R. Subcellular localization of the BRCA1 gene product in mitotic cells. Genes Chromosomes Cancer. 35:2002;193-203.
-
(2002)
Genes Chromosomes Cancer
, vol.35
, pp. 193-203
-
-
Lotti, L.V.1
Ottini, L.2
D'Amico, C.3
Gradini, R.4
Cama, A.5
Belleudi, F.6
Frati, L.7
Torrisi, M.R.8
Mariani-Costantini, R.9
-
4
-
-
0037455691
-
Overexpression of a protein fragment of RNA helicase A causes inhibition of endogenous BRCA1 function and defects in ploidy and cytokinesis in mammary epithelial cells
-
Schlegel B.P., Starita L.M., Parvin J.D. Overexpression of a protein fragment of RNA helicase A causes inhibition of endogenous BRCA1 function and defects in ploidy and cytokinesis in mammary epithelial cells. Oncogene. 22:2003;983-991.
-
(2003)
Oncogene
, vol.22
, pp. 983-991
-
-
Schlegel, B.P.1
Starita, L.M.2
Parvin, J.D.3
-
5
-
-
0029830051
-
Transcriptional activation by BRCA1
-
Chapman M.S., Verma I.M. Transcriptional activation by BRCA1. Nature. 382:1996;678-679.
-
(1996)
Nature
, vol.382
, pp. 678-679
-
-
Chapman, M.S.1
Verma, I.M.2
-
6
-
-
0030474170
-
Evidence for a transcriptional activation function of BRCA1 C-terminal region
-
Monteiro A.N., August A., Hanafusa H. Evidence for a transcriptional activation function of BRCA1 C-terminal region. Proc. Natl. Acad Sci. USA. 93:1996;13595-13599.
-
(1996)
Proc. Natl. Acad Sci. USA
, vol.93
, pp. 13595-13599
-
-
Monteiro, A.N.1
August, A.2
Hanafusa, H.3
-
7
-
-
0030965157
-
BRCA1 is a component of the RNA polymerase II holoenzyme
-
Scully R., Anderson S.F., Chao D.M., Wei W., Ye L., Young R.A., Livingston D.M., Parvin J.D. BRCA1 is a component of the RNA polymerase II holoenzyme. Proc. Natl. Acad Sci. USA. 94:1997;5605-5610.
-
(1997)
Proc. Natl. Acad Sci. USA
, vol.94
, pp. 5605-5610
-
-
Scully, R.1
Anderson, S.F.2
Chao, D.M.3
Wei, W.4
Ye, L.5
Young, R.A.6
Livingston, D.M.7
Parvin, J.D.8
-
8
-
-
0033593432
-
Activation of transcription in vitro by the BRCA1 carboxyl-terminal domain
-
Haile D.T., Parvin J.D. Activation of transcription in vitro by the BRCA1 carboxyl-terminal domain. J. Biol. Chem. 274:1999;2113-2117.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 2113-2117
-
-
Haile, D.T.1
Parvin, J.D.2
-
9
-
-
0035932978
-
From the Cover: Direct DNA binding by Brca1
-
Paull T.T., Cortez D., Bowers B., Elledge S.J., Gellert M. From the Cover: Direct DNA binding by Brca1. Proc. Natl. Acad Sci. USA. 98:2001;6086-6091.
-
(2001)
Proc. Natl. Acad Sci. USA
, vol.98
, pp. 6086-6091
-
-
Paull, T.T.1
Cortez, D.2
Bowers, B.3
Elledge, S.J.4
Gellert, M.5
-
10
-
-
0036682183
-
The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme
-
The domains required for BRCA1 association with the holo-pol were determined, and deletion of the amino-terminal domain resulted in a reduction of BRCA1 association with the RNA polymerase II holoenzyme (holo-pol) by 98%. Because BARD1 was also found associated with the holo-pol, this interaction of BRCA1 with holo-pol might occur via BARD1. The authors also showed that the amino-terminal domain of BRCA1 is essential for association of BRCA1 into foci in S phase of the cell cycle. The BRCT domain had a minor contribution of BRCA1 association with the holo-pol.
-
Chiba N., Parvin J.D. The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme. Cancer Res. 62:2002;4222-4228 The domains required for BRCA1 association with the holo-pol were determined, and deletion of the amino-terminal domain resulted in a reduction of BRCA1 association with the RNA polymerase II holoenzyme (holo-pol) by 98%. Because BARD1 was also found associated with the holo-pol, this interaction of BRCA1 with holo-pol might occur via BARD1. The authors also showed that the amino-terminal domain of BRCA1 is essential for association of BRCA1 into foci in S phase of the cell cycle. The BRCT domain had a minor contribution of BRCA1 association with the holo-pol.
-
(2002)
Cancer Res.
, vol.62
, pp. 4222-4228
-
-
Chiba, N.1
Parvin, J.D.2
-
11
-
-
0031830844
-
BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A
-
Anderson S.F., Schlegel B.P., Nakajima T., Wolpin E.S., Parvin J.D. BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nat. Genet. 19:1998;254-256.
-
(1998)
Nat. Genet.
, vol.19
, pp. 254-256
-
-
Anderson, S.F.1
Schlegel, B.P.2
Nakajima, T.3
Wolpin, E.S.4
Parvin, J.D.5
-
12
-
-
0033612303
-
Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1
-
Harkin D.P., Bean J.M., Miklos D., Song Y.H., Truong V.B., Englert C., Christians F.C., Ellisen L.W., Maheswaran S., Oliner J.D.et al. Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1. Cell. 97:1999;575-586.
-
(1999)
Cell
, vol.97
, pp. 575-586
-
-
Harkin, D.P.1
Bean, J.M.2
Miklos, D.3
Song, Y.H.4
Truong, V.B.5
Englert, C.6
Christians, F.C.7
Ellisen, L.W.8
Maheswaran, S.9
Oliner, J.D.10
-
13
-
-
0034723347
-
BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression
-
MacLachlan T.K., Somasundaram K., Sgagias M., Shifman Y., Muschel R.J., Cowan K.H., El-Deiry W.S. BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression. J. Biol. Chem. 275:2000;2777-2785.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 2777-2785
-
-
MacLachlan, T.K.1
Somasundaram, K.2
Sgagias, M.3
Shifman, Y.4
Muschel, R.J.5
Cowan, K.H.6
El-Deiry, W.S.7
-
14
-
-
0036724986
-
BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair
-
Hartman A.R., Ford J.M. BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair. Nat. Genet. 32:2002;180-184.
-
(2002)
Nat. Genet.
, vol.32
, pp. 180-184
-
-
Hartman, A.R.1
Ford, J.M.2
-
15
-
-
0036261733
-
BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets
-
The authors showed that overexpression of BRCA1 or DNA damage stabilizes the p53 protein, leading to the upregulation of genes normally induced by p53. Genes encoding cell cycle arrest and the DNA-damage response proteins were activated; however, p53-responsive genes that trigger apoptosis were downregulated by BRCA1.
-
MacLachlan T.K., Takimoto R., El-Deiry W.S. BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets. Mol. Cell Biol. 22:2002;4280-4292 The authors showed that overexpression of BRCA1 or DNA damage stabilizes the p53 protein, leading to the upregulation of genes normally induced by p53. Genes encoding cell cycle arrest and the DNA-damage response proteins were activated; however, p53-responsive genes that trigger apoptosis were downregulated by BRCA1.
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 4280-4292
-
-
MacLachlan, T.K.1
Takimoto, R.2
El-Deiry, W.S.3
-
16
-
-
18544368238
-
BRCA1 regulates the interferon gamma-mediated apoptotic response
-
Using an inducible expression system, BRCA1 activates genes that are necessary for apoptosis via the interferon γ pathway, such as IFN56, MxA and IRF-7.
-
Andrews H.N., Mullan P.B., McWilliams S., Sebelova S., Quinn J.E., Gilmore P.M., McCabe N., Pace A., Koller B., Johnston P.G.et al. BRCA1 regulates the interferon gamma-mediated apoptotic response. J. Biol. Chem. 277:2002;26225-26232 Using an inducible expression system, BRCA1 activates genes that are necessary for apoptosis via the interferon γ pathway, such as IFN56, MxA and IRF-7.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 26225-26232
-
-
Andrews, H.N.1
Mullan, P.B.2
McWilliams, S.3
Sebelova, S.4
Quinn, J.E.5
Gilmore, P.M.6
McCabe, N.7
Pace, A.8
Koller, B.9
Johnston, P.G.10
-
17
-
-
0037188479
-
BRCA1 transcriptionally regulates genes involved in breast tumorigenesis
-
Welcsh P.L., Lee M.K., Gonzalez-Hernandez R.M., Black D.J., Mahadevappa M., Swisher E.M., Warrington J.A., King M.C. BRCA1 transcriptionally regulates genes involved in breast tumorigenesis. Proc. Natl. Acad Sci. USA. 99:2002;7560-7565.
-
(2002)
Proc. Natl. Acad Sci. USA
, vol.99
, pp. 7560-7565
-
-
Welcsh, P.L.1
Lee, M.K.2
Gonzalez-Hernandez, R.M.3
Black, D.J.4
Mahadevappa, M.5
Swisher, E.M.6
Warrington, J.A.7
King, M.C.8
-
18
-
-
0030759895
-
Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1
-
Somasundaram K., Zhang H., Zeng Y.X., Houvras Y., Peng Y., Wu G.S., Licht J.D., Weber B.L., El-Deiry W.S. Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1. Nature. 389:1997;187-190.
-
(1997)
Nature
, vol.389
, pp. 187-190
-
-
Somasundaram, K.1
Zhang, H.2
Zeng, Y.X.3
Houvras, Y.4
Peng, Y.5
Wu, G.S.6
Licht, J.D.7
Weber, B.L.8
El-Deiry, W.S.9
-
19
-
-
0032478085
-
BRCA1 regulates p53-dependent gene expression
-
Ouchi T., Monteiro A.N., August A., Aaronson S.A., Hanafusa H. BRCA1 regulates p53-dependent gene expression. Proc. Natl. Acad Sci. USA. 95:1998;2302-2306.
-
(1998)
Proc. Natl. Acad Sci. USA
, vol.95
, pp. 2302-2306
-
-
Ouchi, T.1
Monteiro, A.N.2
August, A.3
Aaronson, S.A.4
Hanafusa, H.5
-
20
-
-
0032473879
-
BRCA1 physically associates with p53 and stimulates its transcriptional activity
-
Zhang H., Somasundaram K., Peng Y., Tian H., Bi D., Weber B.L., El-Deiry W.S. BRCA1 physically associates with p53 and stimulates its transcriptional activity. Oncogene. 16:1998;1713-1721.
-
(1998)
Oncogene
, vol.16
, pp. 1713-1721
-
-
Zhang, H.1
Somasundaram, K.2
Peng, Y.3
Tian, H.4
Bi, D.5
Weber, B.L.6
El-Deiry, W.S.7
-
21
-
-
0032004591
-
Factors associated with the mammalian RNA polymerase II holoenzyme
-
Neish A.S., Anderson S.F., Schlegel B.P., Wei W., Parvin J.D. Factors associated with the mammalian RNA polymerase II holoenzyme. Nucleic Acids Res. 26:1998;847-853.
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 847-853
-
-
Neish, A.S.1
Anderson, S.F.2
Schlegel, B.P.3
Wei, W.4
Parvin, J.D.5
-
22
-
-
0034697973
-
BRCA1 is associated with a human SWI/SNF-related complex: Linking chromatin remodeling to breast cancer
-
Bochar D.A., Wang L., Beniya H., Kinev A., Xue Y., Lane W.S., Wang W., Kashanchi F., Shiekhattar R. BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. Cell. 102:2000;257-265.
-
(2000)
Cell
, vol.102
, pp. 257-265
-
-
Bochar, D.A.1
Wang, L.2
Beniya, H.3
Kinev, A.4
Xue, Y.5
Lane, W.S.6
Wang, W.7
Kashanchi, F.8
Shiekhattar, R.9
-
23
-
-
0033609057
-
BRCA1 interacts with components of the histone deacetylase complex
-
Yarden R.I., Brody L.C. BRCA1 interacts with components of the histone deacetylase complex. Proc. Natl. Acad Sci. USA. 96:1999;4983-4988.
-
(1999)
Proc. Natl. Acad Sci. USA
, vol.96
, pp. 4983-4988
-
-
Yarden, R.I.1
Brody, L.C.2
-
24
-
-
0035842893
-
BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations
-
In an assay of BRCA1 function in regulating chromatin dynamics, BRCA1 was fused to the lac DNA-binding domain and expressed in a cell line containing arrays of the lac operator in the DNA in a large heterochromatin domain. Remarkably, cancer-predisposing mutations within the BRCT repeats enhance the remodeling and also enhance binding to a novel protein co-factor of BRCA1, COBRA1.
-
Ye Q., Hu Y.F., Zhong H., Nye A.C., Belmont A.S., Li R. BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations. J. Cell Biol. 155:2001;911-921 In an assay of BRCA1 function in regulating chromatin dynamics, BRCA1 was fused to the lac DNA-binding domain and expressed in a cell line containing arrays of the lac operator in the DNA in a large heterochromatin domain. Remarkably, cancer-predisposing mutations within the BRCT repeats enhance the remodeling and also enhance binding to a novel protein co-factor of BRCA1, COBRA1.
-
(2001)
J. Cell Biol.
, vol.155
, pp. 911-921
-
-
Ye, Q.1
Hu, Y.F.2
Zhong, H.3
Nye, A.C.4
Belmont, A.S.5
Li, R.6
-
25
-
-
18744372123
-
BRCA1 supports XIST RNA concentration on the inactive X chromosome
-
This study showed that the X inactivation process is defective in cells with mutated or silenced BRCA1. The XIST RNA, which nucleates the silencing of the inactive X chromosome, is expressed at normal levels, but it fails to localize to the chromosome.
-
Ganesan S., Silver D.P., Greenberg R.A., Avni D., Drapkin R., Miron A., Mok S.C., Randrianarison V., Brodie S., Salstrom J.et al. BRCA1 supports XIST RNA concentration on the inactive X chromosome. Cell. 111:2002;393-405 This study showed that the X inactivation process is defective in cells with mutated or silenced BRCA1. The XIST RNA, which nucleates the silencing of the inactive X chromosome, is expressed at normal levels, but it fails to localize to the chromosome.
-
(2002)
Cell
, vol.111
, pp. 393-405
-
-
Ganesan, S.1
Silver, D.P.2
Greenberg, R.A.3
Avni, D.4
Drapkin, R.5
Miron, A.6
Mok, S.C.7
Randrianarison, V.8
Brodie, S.9
Salstrom, J.10
-
26
-
-
0343280013
-
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
-
Paull T.T., Rogakou E.P., Yamazaki V., Kirchgessner C.U., Gellert M., Bonner W.M. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 10:2000;886-895.
-
(2000)
Curr. Biol.
, vol.10
, pp. 886-895
-
-
Paull, T.T.1
Rogakou, E.P.2
Yamazaki, V.3
Kirchgessner, C.U.4
Gellert, M.5
Bonner, W.M.6
-
27
-
-
0032861343
-
Megabase chromatin domains involved in DNA double-strand breaks in vivo
-
Rogakou E.P., Boon C., Redon C., Bonner W.M. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J. Cell Biol. 146:1999;905-916.
-
(1999)
J. Cell Biol.
, vol.146
, pp. 905-916
-
-
Rogakou, E.P.1
Boon, C.2
Redon, C.3
Bonner, W.M.4
-
28
-
-
0034749425
-
DNA damage-dependent nuclear dynamics of the Mre11 complex
-
Mirzoeva O.K., Petrini J.H. DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol. Cell Biol. 21:2001;281-288.
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 281-288
-
-
Mirzoeva, O.K.1
Petrini, J.H.2
-
29
-
-
0037012845
-
Genomic instability in mice lacking histone H2AX
-
The authors generated a knockout mouse for H2AX. There are over 20 H2A genes, and the H2AX variant is a minor component of chromatin; after DNA damage, however, it is rapidly phosphorylated. By deleting this gene, mice were found to be viable but to have a defective repair of DNA damage. In addition, the BRCA1 response after DNA damage of nuclear dot formation was defective.
-
Celeste A., Petersen S., Romanienko P.J., Fernandez-Capetillo O., Chen H.T., Sedelnikova O.A., Reina-San-Martin B., Coppola V., Meffre E., Difilippantonio M.J.et al. Genomic instability in mice lacking histone H2AX. Science. 296:2002;922-927 The authors generated a knockout mouse for H2AX. There are over 20 H2A genes, and the H2AX variant is a minor component of chromatin; after DNA damage, however, it is rapidly phosphorylated. By deleting this gene, mice were found to be viable but to have a defective repair of DNA damage. In addition, the BRCA1 response after DNA damage of nuclear dot formation was defective.
-
(2002)
Science
, vol.296
, pp. 922-927
-
-
Celeste, A.1
Petersen, S.2
Romanienko, P.J.3
Fernandez-Capetillo, O.4
Chen, H.T.5
Sedelnikova, O.A.6
Reina-San-Martin, B.7
Coppola, V.8
Meffre, E.9
Difilippantonio, M.J.10
-
30
-
-
0037062492
-
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
-
•].
-
•].
-
(2002)
Proc. Natl. Acad Sci. USA
, vol.99
, pp. 8173-8178
-
-
Bassing, C.H.1
Chua, K.F.2
Sekiguchi, J.3
Suh, H.4
Whitlow, S.R.5
Fleming, J.C.6
Monroe, B.C.7
Ciccone, D.N.8
Yan, C.9
Vlasakova, K.10
-
31
-
-
0032516654
-
BRCA1 required for transcription-coupled repair of oxidative DNA damage
-
Gowen L.C., Avrutskaya A.V., Latour A.M., Koller B.H., Leadon S.A. BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science. 281:1998;1009-1012.
-
(1998)
Science
, vol.281
, pp. 1009-1012
-
-
Gowen, L.C.1
Avrutskaya, A.V.2
Latour, A.M.3
Koller, B.H.4
Leadon, S.A.5
-
32
-
-
0033603440
-
BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair
-
Abbott D.W., Thompson M.E., Robinson-Benion C., Tomlinson G., Jensen R.A., Holt J.T. BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair. J. Biol. Chem. 274:1999;18808-18812.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 18808-18812
-
-
Abbott, D.W.1
Thompson, M.E.2
Robinson-Benion, C.3
Tomlinson, G.4
Jensen, R.A.5
Holt, J.T.6
-
34
-
-
0033590171
-
BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene
-
Snouwaert J.N., Gowen L.C., Latour A.M., Mohn A.R., Xiao A., DiBiase L., Koller B.H. BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene. Oncogene. 18:1999;7900-7907.
-
(1999)
Oncogene
, vol.18
, pp. 7900-7907
-
-
Snouwaert, J.N.1
Gowen, L.C.2
Latour, A.M.3
Mohn, A.R.4
Xiao, A.5
DiBiase, L.6
Koller, B.H.7
-
35
-
-
0037099520
-
Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts
-
BRCA1 has been implicated in multiple repair pathways, but this is the only study to demonstrate a direct role of full-length BRCA1 in a cell-free biochemical repair assay. Nonhomologous end-joining was dependent upon BRCA1 in the extract, and the BRCA1 dependence was condition-specific, suggesting that at least two nonhomologous end-joining mechanisms exist, and one requires BRCA1.
-
Zhong Q., Boyer T.G., Chen P.L., Lee W.H. Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts. Cancer Res. 62:2002;3966-3970 BRCA1 has been implicated in multiple repair pathways, but this is the only study to demonstrate a direct role of full-length BRCA1 in a cell-free biochemical repair assay. Nonhomologous end-joining was dependent upon BRCA1 in the extract, and the BRCA1 dependence was condition-specific, suggesting that at least two nonhomologous end-joining mechanisms exist, and one requires BRCA1.
-
(2002)
Cancer Res.
, vol.62
, pp. 3966-3970
-
-
Zhong, Q.1
Boyer, T.G.2
Chen, P.L.3
Lee, W.H.4
-
36
-
-
0037047387
-
BRCA1 facilitates microhomology-mediated end-joining of DNA double strand breaks
-
Zhong Q., Chen C.F., Chen P.L., Lee W.H. BRCA1 facilitates microhomology-mediated end-joining of DNA double strand breaks. J. Biol. Chem. 277:2002;28641-28647.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 28641-28647
-
-
Zhong, Q.1
Chen, C.F.2
Chen, P.L.3
Lee, W.H.4
-
37
-
-
0033618621
-
Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response
-
Zhong Q., Chen C.F., Li S., Chen Y., Wang C.C., Xiao J., Chen P.L., Sharp Z.D., Lee W.H. Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. Science. 285:1999;747-750.
-
(1999)
Science
, vol.285
, pp. 747-750
-
-
Zhong, Q.1
Chen, C.F.2
Li, S.3
Chen, Y.4
Wang, C.C.5
Xiao, J.6
Chen, P.L.7
Sharp, Z.D.8
Lee, W.H.9
-
38
-
-
0035914340
-
Redistribution of BRCA1 among four different protein complexes following replication blockage
-
Chiba N., Parvin J.D. Redistribution of BRCA1 among four different protein complexes following replication blockage. J. Biol. Chem. 276:2001;38549-38554.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38549-38554
-
-
Chiba, N.1
Parvin, J.D.2
-
39
-
-
0034308251
-
The lore of the RINGs: Substrate recognition and catalysis by ubiquitin ligases
-
Jackson P.K., Eldridge A.G., Freed E., Furstenthal L., Hsu J.Y., Kaiser B.K., Reimann J.D. The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases. Trends Cell Biol. 10:2000;429-439.
-
(2000)
Trends Cell Biol.
, vol.10
, pp. 429-439
-
-
Jackson, P.K.1
Eldridge, A.G.2
Freed, E.3
Furstenthal, L.4
Hsu, J.Y.5
Kaiser, B.K.6
Reimann, J.D.7
-
40
-
-
0034804672
-
Structure of a BRCA1-BARD1 heterodimeric RING-RING complex
-
Brzovic P.S., Rajagopal P., Hoyt D.W., King M.C., Klevit R.E. Structure of a BRCA1-BARD1 heterodimeric RING-RING complex. Nat. Struct. Biol. 8:2001;833-837.
-
(2001)
Nat. Struct. Biol.
, vol.8
, pp. 833-837
-
-
Brzovic, P.S.1
Rajagopal, P.2
Hoyt, D.W.3
King, M.C.4
Klevit, R.E.5
-
41
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-
0035805582
-
The ring heterodimer brca1-bard1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation
-
Hashizume R., Fukuda M., Maeda I., Nishikawa H., Oyake D., Yabuki Y., Ogata H., Ohta T. The ring heterodimer brca1-bard1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation. J. Biol. Chem. 276:2001;14537-14540.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 14537-14540
-
-
Hashizume, R.1
Fukuda, M.2
Maeda, I.3
Nishikawa, H.4
Oyake, D.5
Yabuki, Y.6
Ogata, H.7
Ohta, T.8
-
43
-
-
0038237514
-
Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein
-
Xia Y., Pao G., Chen H.W., Verma I.M., Hunter T. Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J. Biol. Chem. 278:2002;5255-5263.
-
(2002)
J. Biol. Chem.
, vol.278
, pp. 5255-5263
-
-
Xia, Y.1
Pao, G.2
Chen, H.W.3
Verma, I.M.4
Hunter, T.5
-
44
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-
0037122004
-
Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains
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This study utilized full-length BRCA1-BARD1 and identified that the monoubiquitination of histones by BRCA1-BARD1 was dependent upon automodification with polyubiquitin.
-
Mallery D.L., Vandenberg C.J., Hiom K. Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains. EMBO J. 21:2002;6755-6762 This study utilized full-length BRCA1-BARD1 and identified that the monoubiquitination of histones by BRCA1-BARD1 was dependent upon automodification with polyubiquitin.
-
(2002)
EMBO J.
, vol.21
, pp. 6755-6762
-
-
Mallery, D.L.1
Vandenberg, C.J.2
Hiom, K.3
-
45
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-
0037154159
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Self-assembly properties of a model RING domain
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This biophysical study revealed that RING-domain proteins self-assemble into large complexes. The BRCA1-BARD1 RING domains generate 30 nm super-rings, which may resemble the foci seen in nuclei after DNA damage. These super-ring structures function as scaffolds for a highly processive ubiquitin ligase activity.
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Kentsis A., Gordon R.E., Borden K.L. Self-assembly properties of a model RING domain. Proc. Natl. Acad Sci. USA. 99:2002;667-672 This biophysical study revealed that RING-domain proteins self-assemble into large complexes. The BRCA1-BARD1 RING domains generate 30 nm super-rings, which may resemble the foci seen in nuclei after DNA damage. These super-ring structures function as scaffolds for a highly processive ubiquitin ligase activity.
-
(2002)
Proc. Natl. Acad Sci. USA
, vol.99
, pp. 667-672
-
-
Kentsis, A.1
Gordon, R.E.2
Borden, K.L.3
-
46
-
-
0035979738
-
Regulation of transcriptional activation domain function by ubiquitin
-
Salghetti S.E., Caudy A.A., Chenoweth J.G., Tansey W.P. Regulation of transcriptional activation domain function by ubiquitin. Science. 293:2001;1651-1653.
-
(2001)
Science
, vol.293
, pp. 1651-1653
-
-
Salghetti, S.E.1
Caudy, A.A.2
Chenoweth, J.G.3
Tansey, W.P.4
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48
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0037371682
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Human transcription elongation factor NELF: Identification of novel subunits and reconstitution of the functionally active complex
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Narita T., Yamaguchi Y., Yano K., Sugimoto S., Chanarat S., Wada T., Kim D., Hasegawa J., Omori M., Inukai N.et al. Human transcription elongation factor NELF: Identification of novel subunits and reconstitution of the functionally active complex. Mol. Cell Biol. 23:2003;1863-1873.
-
(2003)
Mol. Cell Biol.
, vol.23
, pp. 1863-1873
-
-
Narita, T.1
Yamaguchi, Y.2
Yano, K.3
Sugimoto, S.4
Chanarat, S.5
Wada, T.6
Kim, D.7
Hasegawa, J.8
Omori, M.9
Inukai, N.10
-
49
-
-
0031194120
-
Assays for investigating transcription by RNA polymerase II in vitro
-
Reines D., Dvir A., Conaway J.W., Conaway R.C. Assays for investigating transcription by RNA polymerase II in vitro. Methods. 12:1997;192-202.
-
(1997)
Methods
, vol.12
, pp. 192-202
-
-
Reines, D.1
Dvir, A.2
Conaway, J.W.3
Conaway, R.C.4
-
50
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-
0032991645
-
Ubiquitination of RNA polymerase II large subunit signaled by phosphorylation of carboxyl-terminal domain
-
Mitsui A., Sharp P.A. Ubiquitination of RNA polymerase II large subunit signaled by phosphorylation of carboxyl-terminal domain. Proc. Natl. Acad Sci. USA. 96:1999;6054-6059.
-
(1999)
Proc. Natl. Acad Sci. USA
, vol.96
, pp. 6054-6059
-
-
Mitsui, A.1
Sharp, P.A.2
-
51
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-
0037007036
-
Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro
-
This study revealed that the inhibition of transcription elongation results in ubiquitination of RNA polymerase II.
-
Lee K.B., Wang D., Lippard S.J., Sharp P.A. Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro. Proc. Natl. Acad Sci. USA. 99:2002;4239-4244 This study revealed that the inhibition of transcription elongation results in ubiquitination of RNA polymerase II.
-
(2002)
Proc. Natl. Acad Sci. USA
, vol.99
, pp. 4239-4244
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-
Lee, K.B.1
Wang, D.2
Lippard, S.J.3
Sharp, P.A.4
-
52
-
-
0029820765
-
Mutations in the yeast SRB2 general transcription factor suppress hpr1-induced recombination and show defects in DNA repair
-
Piruat J.I., Aguilera A. Mutations in the yeast SRB2 general transcription factor suppress hpr1-induced recombination and show defects in DNA repair. Genetics. 143:1996;1533-1542.
-
(1996)
Genetics
, vol.143
, pp. 1533-1542
-
-
Piruat, J.I.1
Aguilera, A.2
-
53
-
-
0031439267
-
The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability
-
Chavez S., Aguilera A. The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability. Genes Dev. 11:1997;3459-3470.
-
(1997)
Genes Dev.
, vol.11
, pp. 3459-3470
-
-
Chavez, S.1
Aguilera, A.2
-
54
-
-
0034534868
-
Pointing (zinc) fingers at BRCA1 targets
-
MacLachlan T.K., El-Deiry W.S. Pointing (zinc) fingers at BRCA1 targets. Nat. Med. 6:2000;1318-1319.
-
(2000)
Nat. Med.
, vol.6
, pp. 1318-1319
-
-
MacLachlan, T.K.1
El-Deiry, W.S.2
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