Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: Visualizing the therapeutic effects of metformin in tumor tissue

Cell Cycle

Volumn 10, Issue 23, 2011, Pages 4047-4064

  Whitaker Menezes, Diana ^a   Martinez Outschoorn, Ubaldo E ^a,b   Flomenberg, Neal ^a,b   Birbe, Ruth C ^a,b   Witkiewicz, Agnieszka K ^a,b   Howell, Anthony ^c   Pavlides, Stephanos ^a   Tsirigos, Aristotelis ^d   Ertel, Adam ^a   Pestell, Richard G ^a,b   Broda, Paolo ^e   Minetti, Carlo ^e   Lisanti, Michael P ^a,b,c,e   Sotgia, Federica ^a,c,e  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d IBM T J WATSON RESEARCH CENTER   (United States)

^e G GASLINI INSTITUTE   (Italy)

Author keywords

Aerobic glycolysis; Autophagy; Cancer metabolism; Complex I; Complex IV; Cytochrome c oxidase (COX); Electron transport; Metformin; Mitochondria; Mitophagy; NADH dehydrogenase; Oxidative phosphorylation (OXPHOS); Respiratory chain; Warburg effect; Warburg's respiratory enzyme

Indexed keywords

BIOLOGICAL MARKER; CATHEPSIN B; CAVEOLIN 1; CYTOCHROME C OXIDASE; GLUTAMINE; HYDROGEN PEROXIDE; KETONE; LACTIC ACID; METFORMIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SUCCINATE DEHYDROGENASE; TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20;

ANAEROBIC GLYCOLYSIS; ARTICLE; AUTOPHAGY; BREAST TUMOR; CANCER CELL; CATABOLISM; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG EFFECT; ENERGY TRANSFER; ENZYME ACTIVITY; EPITHELIUM CELL; FIBROBLAST; FROZEN SECTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MITOCHONDRIAL RESPIRATION; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; TUMOR GROWTH; TUMOR MICROENVIRONMENT;

EID: 82855182002     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.23.18151     Document Type: Article

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