Detecting and targeting mesenchymal-like subpopulations within squamous cell carcinomas

Cell Cycle

Volumn 10, Issue 12, 2011, Pages 2008-2016

  Basu, Devraj ^a,b,c   Montone, Kathleen T ^a   Wang, Li Ping ^a   Gimotty, Phyllis A ^a   Hammond, Rachel ^a   Diehl, J Alan ^a   Rustgi, Anil K ^a   Lee, John T ^c   Rasanen, Kati ^c   Weinstein, Gregory S ^a   Herlyn, Meenhard ^c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c WISTAR INSTITUTE   (United States)

Author keywords

Chemotherapy resistance; EMT; Esophageal cancer; Head and neck cancer; Salinomycin; Squamous cell carcinoma; Tumor heterogeneity

Indexed keywords

CISPLATIN; SALINOMYCIN; UVOMORULIN; VIMENTIN;

ARTICLE; BREAST CARCINOMA; CELL SUBPOPULATION; DRUG RESISTANCE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MESENCHYME CELL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA;

MUS;

EID: 79959260166     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.12.15883     Document Type: Article

References (28)

1. Christiansen JJ, Rajasekaran AK. Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res 2006; 66:8319-26; DOI: 10.1158/0008-5472.CAN-06-0410.
2. Hugo H, Ackland ML, Blick T, Lawrence MG, Clements JA, Williams ED, et al. Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression. J Cell Physiol 2007; 213:374-83; DOI: 10.1002/jcp.21223.
3. Micalizzi DS, Farabaugh SM, Ford HL. Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia 2010; 15:117-34; DOI: 10.1007/s10911-010-9178-9.
4. Guarino M, Rubino B, Ballabio G. The role of epithelial-mesenchymal transition in cancer pathology. Pathology 2007; 39:305-18; DOI: 10.1080/00313020701329914.
5. Singh A, Settleman J. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 2010; 29:4741-51; DOI: 10.1038/onc.2010.215.
6. Basu D, Nguyen TT, Montone KT, Zhang G, Wang LP, Diehl JA, et al. Evidence for mesenchymal-like sub-populations within squamous cell carcinomas possessing chemoresistance and phenotypic plasticity. Oncogene 2010; 29:4170-82; DOI: 10.1038/onc.2010.170.
7. Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008; 133:704-15; DOI: 10.1016/j.cell.2008.03.027.
8. Gupta PB, Onder TT, Jiang G, Tao K, Kuperwasser C, Weinberg RA, et al. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 2009; 138:645-59; DOI: 10.1016/j.cell.2009.06.034.
9. Tarin D, Thompson EW, Newgreen DF. The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Res 2005; 65:5996-6000. (Pubitemid 40994379)
10. Petersen OW, Lind Nielsen H, Gudjonsson T, Villadsen R, Ronnov-Jessen L, Bissell MJ. The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion. Breast Cancer Res 2001; 3:213-7; DOI: 10.1186/bcr298.
11. Yang AD, Fan F, Camp ER, van Buren G, Liu W, Somcio R, et al. Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines. Clin Cancer Res 2006; 12:4147-53; DOI: 10.1158/1078-0432.CCR-06-0038.
12. Wang Z, Li Y, Kong D, Banerjee S, Ahmad A, Azmi AS, et al. Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. Cancer Res 2009; 69:2400-7; DOI: 10.1158/0008-5472.CAN-08-4312.
13. Thomson S, Buck E, Petti F, Griffin G, Brown E, Ramnarine N, et al. Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition. Cancer Res 2005; 65:9455-62; DOI: 10.1158/0008-5472.CAN-05-1058.
14. Yauch RL, Januario T, Eberhard DA, Cavet G, Zhu W, Fu L, et al. Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients. Clin Cancer Res 2005; 11:8686-98; DOI: 10.1158/1078-0432.CCR-05-1492.
15. Fuchs BC, Fujii T, Dorfman JD, Goodwin JM, Zhu AX, Lanuti M, et al. Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells. Cancer Res 2008; 68:2391-9; DOI: 10.1158/0008-5472.CAN-07-2460.
16. Pan Q, Gorin MA, Teknos TN. Pharmacotherapy of head and neck squamous cell carcinoma. Expert Opin Pharmacother 2009; 10:2291-302; DOI: 10.1517/14656560903136754.
17. Bardsley MR, Horvath VJ, Asuzu DT, Lorincz A, Redelman D, Hayashi Y, et al. Kitlow stem cells cause resistance to Kit/platelet-derived growth factor alpha inhibitors in murine gastrointestinal stromal tumors. Gastroenterology 2010; 139:942-52; DOI: 10.1053/j.gastro.2010.05.083.
18. Callaway TR, Edrington TS, Rychlik JL, Genovese KJ, Poole TL, Jung YS, et al. Ionophores: their use as ruminant growth promotants and impact on food safety. Curr Issues Intest Microbiol 2003; 4:43-51; PubMed.
19. Daugschies A, Gasslein U, Rommel M. Comparative efficacy of anticoccidials under the conditions of commercial broiler production and in battery trials. Vet Parasitol 1998; 76:163-71; DOI: 10.1016/S0304-4017(97)00203- 3.
20. Fuchs D, Heinold A, Opelz G, Daniel V, Naujokat C. Salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cells. Biochem Biophys Res Commun 2009; 390:743-9; DOI: 10.1016/j.bbrc.2009.10.042.
21. Fuchs D, Daniel V, Sadeghi M, Opelz G, Naujokat C. Salinomycin overcomes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells. Biochem Biophys Res Commun 2010; 394:1098-104; DOI: 10.1016/j.bbrc.2010.03.138.
22. Riccioni R, Dupuis ML, Bernabei M, Petrucci E, Pasquini L, Mariani G, et al. The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor. Blood Cells Mol Dis 2010; 45:86-92; DOI: 10.1016/j.bcmd.2010.03.008.
23. Li Y, Fang J, Wu S, Ma K, Li H, Yan X, et al. Identification and quantification of salinomycin in intoxicated human plasma by liquid chromatography-electrospray tandem mass spectrometry. Anal Bioanal Chem 2010; 398:955-61; DOI: 10.1007/s00216-010-3999-7.
24. Friedl P, Wolf K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 2003; 3:362-74; DOI: 10.1038/nrc1075.
25. Friedl P, Wolf K. Plasticity of cell migration: a multiscale tuning model. J Cell Biol 2010; 188:11-9; DOI: 10.1083/jcb.200909003.
26. Strauss R, Sova P, Liu Y, Li ZY, Tuve S, Pritchard D, et al. Epithelial phenotype confers resistance of ovarian cancer cells to oncolytic adenoviruses. Cancer Res 2009; 69:5115-25; DOI: 10.1158/0008-5472.CAN-09-0645.
27. Smalley KS, Brafford P, Haass NK, Brandner JM, Brown E, Herlyn M. Upregulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion. Am J Pathol 2005; 166:1541-54; DOI: 10.1016/S0002-9440(10)62370-X.
28. Mancaniello D, Carbonari M. Immunophenotyping and DNA content analysis of acetone-fixed cells. Curr Protoc Cytom 2008; 9:26.