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Volumn 8, Issue 4, 2008, Pages 417-434

EGFR/HER2 in breast cancer: A biological approach for molecular diagnosis and therapy

Author keywords

Basal; Breast cancer; EGF receptor; EGFR; HER2; Monoclonal antibody; Targeted therapy; Triple negative; Tyrosine kinase inhibitor

Indexed keywords

ANTHRACYCLINE; CAPECITABINE; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERLOTINIB; ESTROGEN RECEPTOR; GEFITINIB; LAPATINIB; MATUZUMAB; NAVELBINE; PACLITAXEL; PANITUMUMAB; PERTUZUMAB; TRASTUZUMAB;

EID: 46949101939     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/14737159.8.4.417     Document Type: Review
Times cited : (84)

References (173)
  • 1
    • 0037214253 scopus 로고    scopus 로고
    • Pharmacopathology: A new spin on an old idea
    • Schnitt SJ. Pharmacopathology: a new spin on an old idea. Am. J. Surg. Pathol. 27(1), 121-123(2003).
    • (2003) Am. J. Surg. Pathol , vol.27 , Issue.1 , pp. 121-123
    • Schnitt, S.J.1
  • 2
    • 5644252971 scopus 로고    scopus 로고
    • Molecular approach to breast cancer treatment
    • Yarden Y, Baselga J, Miles D. Molecular approach to breast cancer treatment. Semin. Oncol. 31(5 Suppl. 10), 6-13 (2004).
    • (2004) Semin. Oncol , vol.31 , Issue.5 SUPPL. 10 , pp. 6-13
    • Yarden, Y.1    Baselga, J.2    Miles, D.3
  • 3
    • 36549055697 scopus 로고    scopus 로고
    • Will targeted therapy hold its promise? An evidence-based review
    • Murdoch D, Sager J. Will targeted therapy hold its promise? An evidence-based review. Curr. Opin. Oncol. 20(1), 104-111 (2008).
    • (2008) Curr. Opin. Oncol , vol.20 , Issue.1 , pp. 104-111
    • Murdoch, D.1    Sager, J.2
  • 5
    • 33746782976 scopus 로고    scopus 로고
    • Adjuvant trastuzumab therapy for HER2-overexpressing breast cancer: What we know and what we still need to learn
    • Piccart-Gebhart MJ. Adjuvant trastuzumab therapy for HER2-overexpressing breast cancer: what we know and what we still need to learn. Eur. J. Cancer 42(12), 1715-1719 (2006).
    • (2006) Eur. J. Cancer , vol.42 , Issue.12 , pp. 1715-1719
    • Piccart-Gebhart, M.J.1
  • 6
    • 5644302245 scopus 로고    scopus 로고
    • Future options with trastuzumab for primary systemic and adjuvant therapy
    • Baselga J, Gianni L, Geyer C et al. Future options with trastuzumab for primary systemic and adjuvant therapy. Semin. Oncol. 31(5 Suppl. 10), 51-57 (2004).
    • (2004) Semin. Oncol , vol.31 , Issue.5 SUPPL. 10 , pp. 51-57
    • Baselga, J.1    Gianni, L.2    Geyer, C.3
  • 7
    • 33847718214 scopus 로고    scopus 로고
    • The EGF receptor family: Spearheading a merger of signaling and therapeutics
    • Bublil EM, Yarden Y The EGF receptor family: spearheading a merger of signaling and therapeutics. Curr. Opin. Cell. Biol. 19(2), 124-134 (2007).
    • (2007) Curr. Opin. Cell. Biol , vol.19 , Issue.2 , pp. 124-134
    • Bublil, E.M.1    Yarden, Y.2
  • 8
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
    • Mendelsohn J, Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J. Clin. Oncol. 21(14), 2787-2799 (2003).
    • (2003) J. Clin. Oncol , vol.21 , Issue.14 , pp. 2787-2799
    • Mendelsohn, J.1    Baselga, J.2
  • 9
    • 34547854801 scopus 로고    scopus 로고
    • The oncogene HER2: Its signaling and transforming functions and its role in human cancer pathogenesis
    • Moasser MM. The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis. Oncogene 26(45), 6469-6487 (2007).
    • (2007) Oncogene , vol.26 , Issue.45 , pp. 6469-6487
    • Moasser, M.M.1
  • 10
    • 34547922452 scopus 로고    scopus 로고
    • Targeting the function of the HER2 oncogene in human cancer therapeutics
    • Moasser MM. Targeting the function of the HER2 oncogene in human cancer therapeutics. Oncogene 26(46), 6577-6592 (2007).
    • (2007) Oncogene , vol.26 , Issue.46 , pp. 6577-6592
    • Moasser, M.M.1
  • 11
    • 34249672864 scopus 로고    scopus 로고
    • Trastuzumab: Triumphs and tribulations
    • Nahta R, Esteva FJ. Trastuzumab: triumphs and tribulations. Oncogene 26(25), 3637-3643 (2007).
    • (2007) Oncogene , vol.26 , Issue.25 , pp. 3637-3643
    • Nahta, R.1    Esteva, F.J.2
  • 13
    • 26844559765 scopus 로고    scopus 로고
    • Trastuzumab in the treatment of breast cancer
    • Hortobagyi GN. Trastuzumab in the treatment of breast cancer. N. Engl. J. Med. 353(16), 1734-1736(2005).
    • (2005) N. Engl. J. Med , vol.353 , Issue.16 , pp. 1734-1736
    • Hortobagyi, G.N.1
  • 14
    • 44849117186 scopus 로고    scopus 로고
    • Estimating the magnitude of trastuzumab effects within patient subgroups in the HERA trial
    • Untch M, Gelber RD, Jackisch C et al. Estimating the magnitude of trastuzumab effects within patient subgroups in the HERA trial. Ann. Oncol. 19(6), 1090-1096 (2008).
    • (2008) Ann. Oncol , vol.19 , Issue.6 , pp. 1090-1096
    • Untch, M.1    Gelber, R.D.2    Jackisch, C.3
  • 15
    • 41649083764 scopus 로고    scopus 로고
    • Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial
    • Perez EA, Suman VJ, Davidson NE et al. Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial. J. Clin. Oncol. 26(8), 1231-1238 (2008).
    • (2008) J. Clin. Oncol , vol.26 , Issue.8 , pp. 1231-1238
    • Perez, E.A.1    Suman, V.J.2    Davidson, N.E.3
  • 16
    • 33947317453 scopus 로고    scopus 로고
    • BCIRG 006: 2nd interim analysis Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (ACT) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (ACTH) with docetaxel, carboplatin and trastuzumab (TCH) in HER2neu positive early breast cancer patients
    • Abstract 52
    • Slamon D, Eirmann W, Robert N et al. BCIRG 006: 2nd interim analysis Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (ACT) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (ACTH) with docetaxel, carboplatin and trastuzumab (TCH) in HER2neu positive early breast cancer patients. Breast Cancer Res. Treat. 100(Suppl. 1) (2006) (Abstract 52).
    • (2006) Breast Cancer Res. Treat , Issue.SUPPL. 1 , pp. 100
    • Slamon, D.1    Eirmann, W.2    Robert, N.3
  • 17
    • 33344458106 scopus 로고    scopus 로고
    • Herceptin and the heart - a molecular modifier of cardiac failure
    • Chien KR. Herceptin and the heart - a molecular modifier of cardiac failure. N. Engl. J. Med. 354(8), 789-790 (2006).
    • (2006) N. Engl. J. Med , vol.354 , Issue.8 , pp. 789-790
    • Chien, K.R.1
  • 18
    • 33847147313 scopus 로고    scopus 로고
    • American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer
    • Wolff AC, Hammond ME, Schwartz JN et al. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J. Clin. Oncol. 25(1), 118-145 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.1 , pp. 118-145
    • Wolff, A.C.1    Hammond, M.E.2    Schwartz, J.N.3
  • 19
    • 15544382365 scopus 로고    scopus 로고
    • Assessment of the HER2 status in breast cancer by fluorescence in situ hybridization: A technical review with interpretive guidelines
    • Hicks DG, Tubbs RR. Assessment of the HER2 status in breast cancer by fluorescence in situ hybridization: a technical review with interpretive guidelines. Hum. Pathol. 36(3), 250-261 (2005).
    • (2005) Hum. Pathol , vol.36 , Issue.3 , pp. 250-261
    • Hicks, D.G.1    Tubbs, R.R.2
  • 20
    • 4143150688 scopus 로고    scopus 로고
    • Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma
    • Nielsen TO, Hsu FD, Jensen K et al. Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin. Cancer Res. 10(16), 5367-5374(2004).
    • (2004) Clin. Cancer Res , vol.10 , Issue.16 , pp. 5367-5374
    • Nielsen, T.O.1    Hsu, F.D.2    Jensen, K.3
  • 21
    • 33846587923 scopus 로고    scopus 로고
    • The basal subtype of breast carcinomas may represent the group of breast tumors that could benefit from EGFR-targeted therapies
    • Siziopikou KP, Cobleigh M. The basal subtype of breast carcinomas may represent the group of breast tumors that could benefit from EGFR-targeted therapies. Breast 16(1), 104-107 (2007).
    • (2007) Breast , vol.16 , Issue.1 , pp. 104-107
    • Siziopikou, K.P.1    Cobleigh, M.2
  • 22
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304(5676), 1497-1500 (2004).
    • (2004) Science , vol.304 , Issue.5676 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 23
    • 27244451321 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer
    • Takano T, Ohe Y, Sakamoto H et al. Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer. J. Clin. Oncol. 23(28), 6829-6837 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.28 , pp. 6829-6837
    • Takano, T.1    Ohe, Y.2    Sakamoto, H.3
  • 24
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350(21), 2129-2139 (2004).
    • (2004) N. Engl. J. Med , vol.350 , Issue.21 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 25
    • 41549097718 scopus 로고    scopus 로고
    • EGFR FISH assay predicts for response to cetuximab in chemotherapy refractory colorectal cancer patients
    • Cappuzzo F, Finocchiaro G, Rossi E et al. EGFR FISH assay predicts for response to cetuximab in chemotherapy refractory colorectal cancer patients. Ann. Oncol. 19(4), 717-723 (2008).
    • (2008) Ann. Oncol , vol.19 , Issue.4 , pp. 717-723
    • Cappuzzo, F.1    Finocchiaro, G.2    Rossi, E.3
  • 26
    • 1342281177 scopus 로고    scopus 로고
    • Evaluation of epidermal growth factor receptor (EGFR) by chromogenic in situ hybridization (CISH) and immunohistochemistry (IHC) in archival gliomas using bright-field microscopy
    • Marquez A, Wu R, Zhao J, Tao J, Shi Z. Evaluation of epidermal growth factor receptor (EGFR) by chromogenic in situ hybridization (CISH) and immunohistochemistry (IHC) in archival gliomas using bright-field microscopy. Diagn.Mol. Pathol. 13(1), 1-8 (2004).
    • (2004) Diagn.Mol. Pathol , vol.13 , Issue.1 , pp. 1-8
    • Marquez, A.1    Wu, R.2    Zhao, J.3    Tao, J.4    Shi, Z.5
  • 27
    • 0037429779 scopus 로고    scopus 로고
    • The deaf and the dumb: The biology of ErbB-2 and ErbB-3
    • Citri A, Skaria KB, Yarden Y The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp. Cell. Res. 284(1), 54-65 (2003).
    • (2003) Exp. Cell. Res , vol.284 , Issue.1 , pp. 54-65
    • Citri, A.1    Skaria, K.B.2    Yarden, Y.3
  • 28
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • Hynes NE, Lane HA. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat. Rev. Cancer 5(5), 341-354 (2005).
    • (2005) Nat. Rev. Cancer , vol.5 , Issue.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 29
    • 0037429727 scopus 로고    scopus 로고
    • Stern DE ErbBs in mammary development
    • Stern DE ErbBs in mammary development. Exp. Cell. Res. 284(1), 89-98 (2003).
    • (2003) Exp. Cell. Res , vol.284 , Issue.1 , pp. 89-98
  • 30
    • 3042611780 scopus 로고    scopus 로고
    • Oncogenic growth factor receptors: Implications for signal transduction therapy
    • Mosesson Y, Yarden Y Oncogenic growth factor receptors: implications for signal transduction therapy. Semin. Cancer Biol. 14(4), 262-270 (2004).
    • (2004) Semin. Cancer Biol , vol.14 , Issue.4 , pp. 262-270
    • Mosesson, Y.1    Yarden, Y.2
  • 31
    • 0042029746 scopus 로고    scopus 로고
    • Muc4/sialomucin complex, the intramembrane ErbB2 ligand, translocates ErbB2 to the apical surface in polarized epithelial cells
    • Ramsauer VP, Carraway CA, Salas PJ, Carraway KL. Muc4/sialomucin complex, the intramembrane ErbB2 ligand, translocates ErbB2 to the apical surface in polarized epithelial cells. J. Biol. Chem. 278(32), 30142-30147 (2003).
    • (2003) J. Biol. Chem , vol.278 , Issue.32 , pp. 30142-30147
    • Ramsauer, V.P.1    Carraway, C.A.2    Salas, P.J.3    Carraway, K.L.4
  • 32
    • 0042307325 scopus 로고    scopus 로고
    • The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation
    • Holbro T, Beerli RR, Maurer F et al. The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Proc. Natl Acad. Sci. USA 100(15), 8933-8938 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , Issue.15 , pp. 8933-8938
    • Holbro, T.1    Beerli, R.R.2    Maurer, F.3
  • 33
    • 34547601870 scopus 로고    scopus 로고
    • A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration
    • Katz M, Amit I, Citri A et al. A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration. Nat. Cell Biol. 9(8), 961-969 (2007).
    • (2007) Nat. Cell Biol , vol.9 , Issue.8 , pp. 961-969
    • Katz, M.1    Amit, I.2    Citri, A.3
  • 34
    • 0038575385 scopus 로고    scopus 로고
    • Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer
    • Witton CJ, Reeves JR, Going JJ, Cooke TG, Bartlett JM. Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer. J. Pathol. 200(3), 290-297 (2003).
    • (2003) J. Pathol , vol.200 , Issue.3 , pp. 290-297
    • Witton, C.J.1    Reeves, J.R.2    Going, J.J.3    Cooke, T.G.4    Bartlett, J.M.5
  • 35
    • 0031730476 scopus 로고    scopus 로고
    • Expression of c-erbB3 protein in primary breast carcinomas
    • Naidu R, Yadav M, Nair S, Kutty MK. Expression of c-erbB3 protein in primary breast carcinomas. Br. J. Cancer 78(10), 1385-1390 (1998).
    • (1998) Br. J. Cancer , vol.78 , Issue.10 , pp. 1385-1390
    • Naidu, R.1    Yadav, M.2    Nair, S.3    Kutty, M.K.4
  • 36
    • 0033747558 scopus 로고    scopus 로고
    • Prognostic value of the type I growth factor receptors in a large series of human primary breast cancers quantified with a real-time reverse transcription-polymerase chain reaction assay
    • Pawlowski V, Revillion F, Hebbar M, Hornez L, Peyrat JP Prognostic value of the type I growth factor receptors in a large series of human primary breast cancers quantified with a real-time reverse transcription-polymerase chain reaction assay. Clin. Cancer Res. 6(11), 4217-4225 (2000).
    • (2000) Clin. Cancer Res , vol.6 , Issue.11 , pp. 4217-4225
    • Pawlowski, V.1    Revillion, F.2    Hebbar, M.3    Hornez, L.4    Peyrat, J.P.5
  • 37
    • 0036145181 scopus 로고    scopus 로고
    • EGFR family expression in breast carcinomas. c-erbB-2 and c-erbB-4 receptors have different effects on survival
    • Suo Z, Risberg B, Kalsson MG et al. EGFR family expression in breast carcinomas. c-erbB-2 and c-erbB-4 receptors have different effects on survival. J. Pathol. 196(1), 17-25 (2002).
    • (2002) J. Pathol , vol.196 , Issue.1 , pp. 17-25
    • Suo, Z.1    Risberg, B.2    Kalsson, M.G.3
  • 38
    • 37849046940 scopus 로고    scopus 로고
    • ErbB/HER ligands in human breast cancer and relationships with their receptors, the bio-pathological features and prognosis
    • Revillion F, Lhotellier V, Hornez L, Bonneterre J, Peyrat JP. ErbB/HER ligands in human breast cancer and relationships with their receptors, the bio-pathological features and prognosis. Ann. Oncol. 19(1), 73-80 (2008).
    • (2008) Ann. Oncol , vol.19 , Issue.1 , pp. 73-80
    • Revillion, F.1    Lhotellier, V.2    Hornez, L.3    Bonneterre, J.4    Peyrat, J.P.5
  • 39
    • 34547871259 scopus 로고    scopus 로고
    • Targeting HER proteins in cancer therapy and the role of the non-target HER3
    • Hsieh AC, Moasser MM. Targeting HER proteins in cancer therapy and the role of the non-target HER3. Br. J. Cancer 97(4), 453-457 (2007).
    • (2007) Br. J. Cancer , vol.97 , Issue.4 , pp. 453-457
    • Hsieh, A.C.1    Moasser, M.M.2
  • 40
    • 0016000929 scopus 로고
    • Epidermal growth factor: Chemical and biological characterization
    • Cohen S, Taylor JM. Epidermal growth factor: chemical and biological characterization. Recent Prog. Horm. Res. 30(0), 533-550(1974).
    • (1974) Recent Prog. Horm. Res , vol.30 , Issue.0 , pp. 533-550
    • Cohen, S.1    Taylor, J.M.2
  • 41
    • 0037285971 scopus 로고    scopus 로고
    • Growth factor receptors in breast cancer: Potential for therapeutic intervention
    • Nahta R, Hortobagyi GN, Esteva FJ. Growth factor receptors in breast cancer: potential for therapeutic intervention. Oncologist 8(1), 5-17 (2003).
    • (2003) Oncologist , vol.8 , Issue.1 , pp. 5-17
    • Nahta, R.1    Hortobagyi, G.N.2    Esteva, F.J.3
  • 42
    • 0010066582 scopus 로고
    • A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma
    • Semba K, Kamata N, Toyoshima K, Yamamoto T A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma. Proc. Natl Acad. Sci. USA 82(19), 6497-6501 (1985).
    • (1985) Proc. Natl Acad. Sci. USA , vol.82 , Issue.19 , pp. 6497-6501
    • Semba, K.1    Kamata, N.2    Toyoshima, K.3    Yamamoto, T.4
  • 43
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 100(1), 57-70 (2000).
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 44
    • 0038461104 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) as a target in cancer therapy: Understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs
    • Ciardiello F, Tortora G. Epidermal growth factor receptor (EGFR) as a target in cancer therapy: understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs. Eur. J. Cancer 39(10), 1348-1354 (2003).
    • (2003) Eur. J. Cancer , vol.39 , Issue.10 , pp. 1348-1354
    • Ciardiello, F.1    Tortora, G.2
  • 45
    • 33745761030 scopus 로고    scopus 로고
    • Amplification of the epidermal growth factor receptor in astrocytic tumours by chromogenic in situ hybridization: Association with clinicopathological features and patient survival
    • Jarvela S, Helin H, Haapasalo J et al. Amplification of the epidermal growth factor receptor in astrocytic tumours by chromogenic in situ hybridization: association with clinicopathological features and patient survival. Neuropathol Appl. Neurobiol. 32(4), 441-450 (2006).
    • (2006) Neuropathol Appl. Neurobiol , vol.32 , Issue.4 , pp. 441-450
    • Jarvela, S.1    Helin, H.2    Haapasalo, J.3
  • 46
    • 4544258999 scopus 로고    scopus 로고
    • EGFR and EGFRvIII expression in primary breast cancer and cell lines
    • Rae JM, Scheys JO, Clark KM et al. EGFR and EGFRvIII expression in primary breast cancer and cell lines. Breast Cancer Res. Treat. 87(1), 87-95 (2004).
    • (2004) Breast Cancer Res. Treat , vol.87 , Issue.1 , pp. 87-95
    • Rae, J.M.1    Scheys, J.O.2    Clark, K.M.3
  • 47
    • 35348848403 scopus 로고    scopus 로고
    • Prognostic significance of overexpression and phosphorylation of epidermal growth factor receptor (EGFR) and the presence of truncated EGFRvIII in locoregionally advanced breast cancer
    • Nieto Y Nawaz F, Jones RB, Shpall EJ, Nawaz S. Prognostic significance of overexpression and phosphorylation of epidermal growth factor receptor (EGFR) and the presence of truncated EGFRvIII in locoregionally advanced breast cancer. J. Clin. Oncol. 25(28), 4405-4413 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.28 , pp. 4405-4413
    • Nieto, Y.1    Nawaz, F.2    Jones, R.B.3    Shpall, E.J.4    Nawaz, S.5
  • 48
    • 1842591231 scopus 로고    scopus 로고
    • Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases
    • Marmor MD, Yarden Y Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases. Oncogene 23(11), 2057-2070 (2004).
    • (2004) Oncogene , vol.23 , Issue.11 , pp. 2057-2070
    • Marmor, M.D.1    Yarden, Y.2
  • 49
    • 0035895664 scopus 로고    scopus 로고
    • Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases
    • Waterman H, Yarden Y Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases. FEBS Lett. 490(3), 142-152 (2001).
    • (2001) FEBS Lett , vol.490 , Issue.3 , pp. 142-152
    • Waterman, H.1    Yarden, Y.2
  • 50
    • 33646394318 scopus 로고    scopus 로고
    • Disruption of the Y-box binding protein-1 results in suppression of the epidermal growth factor receptor and HER-2
    • Wu J, Lee C, Yokom D et al. Disruption of the Y-box binding protein-1 results in suppression of the epidermal growth factor receptor and HER-2. Cancer Res. 66(9), 4872-4879 (2006).
    • (2006) Cancer Res , vol.66 , Issue.9 , pp. 4872-4879
    • Wu, J.1    Lee, C.2    Yokom, D.3
  • 51
    • 18844457596 scopus 로고    scopus 로고
    • Y-box-binding protein 1 confers EGF independence to human mammary epithelial cells
    • Berquin IM, Pang B, Dziubinski ML et al. Y-box-binding protein 1 confers EGF independence to human mammary epithelial cells. Oncogene 24(19), 3177-3186 (2005).
    • (2005) Oncogene , vol.24 , Issue.19 , pp. 3177-3186
    • Berquin, I.M.1    Pang, B.2    Dziubinski, M.L.3
  • 52
    • 33750627353 scopus 로고    scopus 로고
    • Mutational analysis of the HER2 gene in lung tumors from Caucasian patients: Mutations are mainly present in adenocarcinomas with bronchioloalveolar features
    • Buttitta F, Barassi F, Fresu G et al. Mutational analysis of the HER2 gene in lung tumors from Caucasian patients: mutations are mainly present in adenocarcinomas with bronchioloalveolar features. Int. J. Cancer 119(11), 2586-2591 (2006).
    • (2006) Int. J. Cancer , vol.119 , Issue.11 , pp. 2586-2591
    • Buttitta, F.1    Barassi, F.2    Fresu, G.3
  • 53
    • 20144386787 scopus 로고    scopus 로고
    • Somatic mutations of the HER2 kinase domain in lung adenocarcinomas
    • Shigematsu H, Takahashi T, Nomura M et al. Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. Cancer Res. 65(5), 1642-1646 (2005).
    • (2005) Cancer Res , vol.65 , Issue.5 , pp. 1642-1646
    • Shigematsu, H.1    Takahashi, T.2    Nomura, M.3
  • 54
    • 21644441867 scopus 로고    scopus 로고
    • Yin Yang 1 cooperates with activator protein 2 to stimulate ERBB2 gene expression in mammary cancer cells
    • Begon DY, Delacroix L, Vernimmen D, Jackers P, Winkler R. Yin Yang 1 cooperates with activator protein 2 to stimulate ERBB2 gene expression in mammary cancer cells. J. Biol. Chem. 280(26), 24428-24434 (2005).
    • (2005) J. Biol. Chem , vol.280 , Issue.26 , pp. 24428-24434
    • Begon, D.Y.1    Delacroix, L.2    Vernimmen, D.3    Jackers, P.4    Winkler, R.5
  • 55
    • 0141841783 scopus 로고    scopus 로고
    • Different mechanisms are implicated in ERBB2 gene overexpression in breast and in other cancers
    • Vernimmen D, Gueders M, Pisvin S, Delvenne P Winkler R. Different mechanisms are implicated in ERBB2 gene overexpression in breast and in other cancers. Br. J. Cancer 89(5), 899-906 (2003).
    • (2003) Br. J. Cancer , vol.89 , Issue.5 , pp. 899-906
    • Vernimmen, D.1    Gueders, M.2    Pisvin, S.3    Delvenne, P.4    Winkler, R.5
  • 56
    • 1942431966 scopus 로고    scopus 로고
    • The achilles heel of ErbB-2/HER2: Regulation by the Hsp90 chaperone machine and potential for pharmacological intervention
    • Citri A, Kochupurakkal BS, Yarden Y The achilles heel of ErbB-2/HER2: regulation by the Hsp90 chaperone machine and potential for pharmacological intervention. Cell Cycle 3(1), 51-60 (2004).
    • (2004) Cell Cycle , vol.3 , Issue.1 , pp. 51-60
    • Citri, A.1    Kochupurakkal, B.S.2    Yarden, Y.3
  • 57
    • 12144266330 scopus 로고    scopus 로고
    • Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation
    • 512, 1165-1170
    • Citri A, Gan J, Mosesson Y et al. Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation. EMBO Rep. 5(12), 1165-1170(2004).
    • (2004) EMBO Rep
    • Citri, A.1    Gan, J.2    Mosesson, Y.3
  • 58
    • 33744931946 scopus 로고    scopus 로고
    • Hsp90 recognizes a common surface on client kinases
    • Citri A, Harari D, Shohat G et al. Hsp90 recognizes a common surface on client kinases. J. Biol. Chem. 281(20), 14361-14369 (2006).
    • (2006) J. Biol. Chem , vol.281 , Issue.20 , pp. 14361-14369
    • Citri, A.1    Harari, D.2    Shohat, G.3
  • 59
    • 33847638137 scopus 로고    scopus 로고
    • Estimates of the cancer incidence and mortality in Europe in 2006
    • Ferlay J, Autier P, Boniol M et al. Estimates of the cancer incidence and mortality in Europe in 2006. Ann. Oncol. 18(3), 581-592 (2007).
    • (2007) Ann. Oncol , vol.18 , Issue.3 , pp. 581-592
    • Ferlay, J.1    Autier, P.2    Boniol, M.3
  • 60
    • 46949097619 scopus 로고    scopus 로고
    • Tumours of the breast. In: World Health Organization Classification of Tumours -Pathology and Genetics of Tumours of the Breast and Female Genital Organs. Tavassoli FA, Devilee P (Eds). IARC Press, Lyon, France (2003).
    • Tumours of the breast. In: World Health Organization Classification of Tumours -Pathology and Genetics of Tumours of the Breast and Female Genital Organs. Tavassoli FA, Devilee P (Eds). IARC Press, Lyon, France (2003).
  • 62
    • 34548536058 scopus 로고    scopus 로고
    • Prognostic and predictive value of centrally reviewed expression of estrogen and progesterone receptors in a randomized trial comparing letrozole and tamoxifen adjuvant therapy for postmenopausal early breast cancer: BIG 1-98
    • Viale G, Regan MM, Maiorano E et al. Prognostic and predictive value of centrally reviewed expression of estrogen and progesterone receptors in a randomized trial comparing letrozole and tamoxifen adjuvant therapy for postmenopausal early breast cancer: BIG 1-98. J. Clin. Oncol. 25(25), 3846-3852 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.25 , pp. 3846-3852
    • Viale, G.1    Regan, M.M.2    Maiorano, E.3
  • 63
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, Sorlie T, Eisen MB et al. Molecular portraits of human breast tumours. Nature 406(6797), 747-752 (2000).
    • (2000) Nature , vol.406 , Issue.6797 , pp. 747-752
    • Perou, C.M.1    Sorlie, T.2    Eisen, M.B.3
  • 64
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sorlie T, Perou CM, Tibshirani R et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl Acad. Sci. USA 98(19), 10869-10874(2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , Issue.19 , pp. 10869-10874
    • Sorlie, T.1    Perou, C.M.2    Tibshirani, R.3
  • 65
    • 0037137519 scopus 로고    scopus 로고
    • A gene-expression signature as a predictor of survival in breast cancer
    • van de Vijver MJ, He YD, van't Veer LJ et al. A gene-expression signature as a predictor of survival in breast cancer. N. Engl. J. Med. 347(25), 1999-2009 (2002).
    • (2002) N. Engl. J. Med , vol.347 , Issue.25 , pp. 1999-2009
    • van de Vijver, M.J.1    He, Y.D.2    van't Veer, L.J.3
  • 66
    • 34247145491 scopus 로고    scopus 로고
    • Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade
    • Loi S, Haibe-Kains B, Desmedt C et al. Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade. J. Clin. Oncol. 25(10), 1239-1246 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.10 , pp. 1239-1246
    • Loi, S.1    Haibe-Kains, B.2    Desmedt, C.3
  • 67
    • 33645820586 scopus 로고    scopus 로고
    • Estrogen-regulated genes predict survival in hormone receptor-positive breast cancers
    • Oh DS, Troester MA, Usary J et al. Estrogen-regulated genes predict survival in hormone receptor-positive breast cancers. J. Clin. Oncol. 24(11), 1656-1664 (2006).
    • (2006) J. Clin. Oncol , vol.24 , Issue.11 , pp. 1656-1664
    • Oh, D.S.1    Troester, M.A.2    Usary, J.3
  • 68
    • 35048864555 scopus 로고    scopus 로고
    • Molecular classification system identifies invasive breast carcinoma patients who are most likely and those who are least likely to achieve a complete pathologic response after neoadjuvant chemotherapy
    • Goldstein NS, Decker D, Severson D et al. Molecular classification system identifies invasive breast carcinoma patients who are most likely and those who are least likely to achieve a complete pathologic response after neoadjuvant chemotherapy. Cancer 110(8), 1687-1696(2007).
    • (2007) Cancer , vol.110 , Issue.8 , pp. 1687-1696
    • Goldstein, N.S.1    Decker, D.2    Severson, D.3
  • 69
    • 27644567107 scopus 로고    scopus 로고
    • p63, cytokeratin 5, and P-cadherin: Three molecular markers to distinguish basal phenotype in breast carcinomas
    • Matos I, Dufloth R, Alvarenga M, Zeferino LC, Schmitt F. p63, cytokeratin 5, and P-cadherin: three molecular markers to distinguish basal phenotype in breast carcinomas. Virchows Arch. 447(4), 688-694 (2005).
    • (2005) Virchows Arch , vol.447 , Issue.4 , pp. 688-694
    • Matos, I.1    Dufloth, R.2    Alvarenga, M.3    Zeferino, L.C.4    Schmitt, F.5
  • 70
    • 84925550146 scopus 로고    scopus 로고
    • Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: Immunohistochemical and chromogenic in situ hybridization analysis
    • Reis-Filho JS, Milanezi F, Carvalho S et al. Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis. Breast Cancer Res. 7(6), R1028-R1035 (2005).
    • (2005) Breast Cancer Res , vol.7 , Issue.6
    • Reis-Filho, J.S.1    Milanezi, F.2    Carvalho, S.3
  • 71
    • 20144387584 scopus 로고    scopus 로고
    • Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers
    • Palacios J, Honrado E, Osorio A et al. Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers. Breast Cancer Res. Treat. 90(1), 5-14 (2005).
    • (2005) Breast Cancer Res. Treat , vol.90 , Issue.1 , pp. 5-14
    • Palacios, J.1    Honrado, E.2    Osorio, A.3
  • 72
    • 0036997114 scopus 로고    scopus 로고
    • Aberrant P-cadherin expression: Is it associated with estrogen-independent growth in breast cancer?
    • Paredes J, Milanezi F, Reis-Filho JS et al. Aberrant P-cadherin expression: is it associated with estrogen-independent growth in breast cancer? Pathol. Res. Pract. 198(12), 795-801 (2002).
    • (2002) Pathol. Res. Pract , vol.198 , Issue.12 , pp. 795-801
    • Paredes, J.1    Milanezi, F.2    Reis-Filho, J.S.3
  • 73
    • 0037347755 scopus 로고    scopus 로고
    • Novel and classic myoepithelial/stem cell markers in metaplastic carcinomas of the breast
    • Reis-Filho JS, Milanezi F, Paredes J et al. Novel and classic myoepithelial/stem cell markers in metaplastic carcinomas of the breast. Appl. Immunohistochem. Mol. Morphol. 11(1), 1-8 (2003).
    • (2003) Appl. Immunohistochem. Mol. Morphol , vol.11 , Issue.1 , pp. 1-8
    • Reis-Filho, J.S.1    Milanezi, F.2    Paredes, J.3
  • 74
    • 33746911642 scopus 로고    scopus 로고
    • EGFR amplification and lack of activating mutations in metaplastic breast carcinomas
    • Reis-Filho J, Pinheiro C, Lambros M et al. EGFR amplification and lack of activating mutations in metaplastic breast carcinomas. J. Pathol. 209, 445-453 (2006).
    • (2006) J. Pathol , vol.209 , pp. 445-453
    • Reis-Filho, J.1    Pinheiro, C.2    Lambros, M.3
  • 75
    • 33745653114 scopus 로고    scopus 로고
    • Metaplastic breast carcinomas are basal-like tumours
    • Reis-Filho JS, Milanezi F, Steele D et al. Metaplastic breast carcinomas are basal-like tumours. Histopathology 49(1), 10-21 (2006).
    • (2006) Histopathology , vol.49 , Issue.1 , pp. 10-21
    • Reis-Filho, J.S.1    Milanezi, F.2    Steele, D.3
  • 76
    • 33847292843 scopus 로고    scopus 로고
    • Breast carcinoma with basal differentiation: A proposal for pathology definition based on basal cytokeratin expression
    • Rakha EA, El-Sayed ME, Green AR et al. Breast carcinoma with basal differentiation: a proposal for pathology definition based on basal cytokeratin expression. Histopathology 50(4), 434-438 (2007).
    • (2007) Histopathology , vol.50 , Issue.4 , pp. 434-438
    • Rakha, E.A.1    El-Sayed, M.E.2    Green, A.R.3
  • 77
    • 37248999372 scopus 로고    scopus 로고
    • Triple negative tumours: A critical review
    • Reis-Filho JS, Tutt AN. Triple negative tumours: a critical review. Histopathology 52(1), 108-118 (2008).
    • (2008) Histopathology , vol.52 , Issue.1 , pp. 108-118
    • Reis-Filho, J.S.1    Tutt, A.N.2
  • 78
    • 30944450821 scopus 로고    scopus 로고
    • Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma
    • Livasy CA, Karaca G, Nanda R et al. Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma. Mod. Pathol. 19(2), 264-271 (2006).
    • (2006) Mod. Pathol , vol.19 , Issue.2 , pp. 264-271
    • Livasy, C.A.1    Karaca, G.2    Nanda, R.3
  • 79
    • 40449115153 scopus 로고    scopus 로고
    • P-cadherin expression in breast cancer: A review
    • Paredes J, Correia AL, Ribeiro AS et al. P-cadherin expression in breast cancer: a review. Breast Cancer Res. 9(5), 214 (2007).
    • (2007) Breast Cancer Res , vol.9 , Issue.5 , pp. 214
    • Paredes, J.1    Correia, A.L.2    Ribeiro, A.S.3
  • 80
    • 33845215486 scopus 로고    scopus 로고
    • Basal phenotype identifies a poor prognostic subgroup of breast cancer of clinical importance
    • Rakha EA, El-Rehim DA, Paish C et al. Basal phenotype identifies a poor prognostic subgroup of breast cancer of clinical importance. Eur. J. Cancer 42(18), 3149-3156 (2006).
    • (2006) Eur. J. Cancer , vol.42 , Issue.18 , pp. 3149-3156
    • Rakha, E.A.1    El-Rehim, D.A.2    Paish, C.3
  • 81
    • 38149124802 scopus 로고    scopus 로고
    • The influence of basal phenotype on the metastatic pattern of breast cancer
    • Luck AA, Evans AJ, Green AR et al. The influence of basal phenotype on the metastatic pattern of breast cancer. Clin. Oncol. (R. Coll. Radiol.) 20(1), 40-45 (2008).
    • (2008) Clin. Oncol. (R. Coll. Radiol.) , vol.20 , Issue.1 , pp. 40-45
    • Luck, A.A.1    Evans, A.J.2    Green, A.R.3
  • 82
    • 33744750480 scopus 로고    scopus 로고
    • Basal-like breast carcinomas: Clinical outcome and response to chemotherapy
    • Banerjee S, Reis-Filho JS, Ashley S et al. Basal-like breast carcinomas: clinical outcome and response to chemotherapy. J. Clin. Pathol. 59(7), 729-735 (2006).
    • (2006) J. Clin. Pathol , vol.59 , Issue.7 , pp. 729-735
    • Banerjee, S.1    Reis-Filho, J.S.2    Ashley, S.3
  • 83
    • 37448999035 scopus 로고    scopus 로고
    • Triple negative breast cancer: Molecular profiling and prognostic impact in adjuvant anthracycline-treated patients
    • Epub ahead of print
    • Tan DS, Marchio C, Jones RL et al. Triple negative breast cancer: molecular profiling and prognostic impact in adjuvant anthracycline-treated patients. Breast Cancer Res. Treat. (2007) (Epub ahead of print).
    • (2007) Breast Cancer Res. Treat
    • Tan, D.S.1    Marchio, C.2    Jones, R.L.3
  • 84
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235(4785), 177-182 (1987).
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 85
    • 38149032775 scopus 로고    scopus 로고
    • Basal-HER2 phenotype shows poorer survival than basal-like phenotype in hormone receptor-negative invasive breast cancers
    • Liu H, Fan Q, Zhang Z et al. Basal-HER2 phenotype shows poorer survival than basal-like phenotype in hormone receptor-negative invasive breast cancers. Hum. Pathol. 39(2), 167-174 (2008).
    • (2008) Hum. Pathol , vol.39 , Issue.2 , pp. 167-174
    • Liu, H.1    Fan, Q.2    Zhang, Z.3
  • 86
    • 33947246109 scopus 로고    scopus 로고
    • Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer
    • Harris LN, You F, Schnitt SJ et al. Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer. Clin. Cancer Res. 13(4), 1198-1207 (2007).
    • (2007) Clin. Cancer Res , vol.13 , Issue.4 , pp. 1198-1207
    • Harris, L.N.1    You, F.2    Schnitt, S.J.3
  • 87
    • 34247363714 scopus 로고    scopus 로고
    • Standardization of HER2 testing: Results of an international proficiency-testing ring study
    • Dowsett M, Hanna WM, Kockx M et al. Standardization of HER2 testing: results of an international proficiency-testing ring study. Mod. Pathol. 20(5), 584-591 (2007).
    • (2007) Mod. Pathol , vol.20 , Issue.5 , pp. 584-591
    • Dowsett, M.1    Hanna, W.M.2    Kockx, M.3
  • 88
    • 36849069347 scopus 로고    scopus 로고
    • American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer
    • Harris L, Fritsche H, Mennel R et al. American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer. J. Clin. Oncol. 25(33), 5287-5312 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.33 , pp. 5287-5312
    • Harris, L.1    Fritsche, H.2    Mennel, R.3
  • 89
    • 38049103907 scopus 로고    scopus 로고
    • HER2 status and efficacy of adjuvant anthracyclines in early breast cancer: A pooled analysis of randomized trials
    • Gennari A, Sormani MP, Pronzato P et al. HER2 status and efficacy of adjuvant anthracyclines in early breast cancer: a pooled analysis of randomized trials. J. Natl Cancer Inst. 100(1), 14-20 (2008).
    • (2008) J. Natl Cancer Inst , vol.100 , Issue.1 , pp. 14-20
    • Gennari, A.1    Sormani, M.P.2    Pronzato, P.3
  • 90
    • 32944475493 scopus 로고    scopus 로고
    • Retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group
    • Knoop AS, Knudsen H, Balslev E et al. Retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group. J. Clin. Oncol. 23(30), 7483-7490 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.30 , pp. 7483-7490
    • Knoop, A.S.1    Knudsen, H.2    Balslev, E.3
  • 91
    • 0036091354 scopus 로고    scopus 로고
    • HER-2 amplification and topoisomerase IIα gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil
    • Di Leo A, Gancberg D, Larsimont D et al. HER-2 amplification and topoisomerase IIα gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil. Clin. Cancer Res. 8(5), 1107-1116 (2002).
    • (2002) Clin. Cancer Res , vol.8 , Issue.5 , pp. 1107-1116
    • Di Leo, A.1    Gancberg, D.2    Larsimont, D.3
  • 92
    • 0033870292 scopus 로고    scopus 로고
    • Amplification and deletion of topoisomerase IIα associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer
    • Jarvinen TA, Tanner M, Rantanen V et al. Amplification and deletion of topoisomerase IIα associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer. Am. J. Pathol. 156(3), 839-847 (2000).
    • (2000) Am. J. Pathol , vol.156 , Issue.3 , pp. 839-847
    • Jarvinen, T.A.1    Tanner, M.2    Rantanen, V.3
  • 93
    • 0035884620 scopus 로고    scopus 로고
    • Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: Evidence from a Phase III randomized trial
    • Ellis MJ, Coop A, Singh B et al. Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a Phase III randomized trial. J. Clin. Oncol. 19(18), 3808-3816 (2001).
    • (2001) J. Clin. Oncol , vol.19 , Issue.18 , pp. 3808-3816
    • Ellis, M.J.1    Coop, A.2    Singh, B.3
  • 94
    • 37449028688 scopus 로고    scopus 로고
    • Arimidex T, Alone or in Combination (ATAC) Trialists' Group, Forbes JF et al. Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial. Lancet Oncol. 9(1), 45-53 (2008).
    • Arimidex T, Alone or in Combination (ATAC) Trialists' Group, Forbes JF et al. Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial. Lancet Oncol. 9(1), 45-53 (2008).
  • 95
    • 20244374413 scopus 로고    scopus 로고
    • Biomarker changes during neoadjuvant anastrozole, tamoxifen, or the combination: Influence of hormonal status and HER-2 in breast cancer - a study from the IMPACT trialists
    • Dowsett M, Ebbs SR, Dixon JM et al. Biomarker changes during neoadjuvant anastrozole, tamoxifen, or the combination: influence of hormonal status and HER-2 in breast cancer - a study from the IMPACT trialists. J. Clin. Oncol. 23(11), 2477-2492 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.11 , pp. 2477-2492
    • Dowsett, M.1    Ebbs, S.R.2    Dixon, J.M.3
  • 96
    • 37549056583 scopus 로고    scopus 로고
    • Adjuvant letrozole versus tamoxifen according to centrally-assessed ERBB2 status for postmenopausal women with endocrine-responsive early breast cancer: Supplementary results from the BIG 1-98 randomised trial
    • Rasmussen BB, Regan MM, Lykkesfeldt AE et al. Adjuvant letrozole versus tamoxifen according to centrally-assessed ERBB2 status for postmenopausal women with endocrine-responsive early breast cancer: supplementary results from the BIG 1-98 randomised trial. Lancet Oncol. 9(1), 23-28 (2008).
    • (2008) Lancet Oncol , vol.9 , Issue.1 , pp. 23-28
    • Rasmussen, B.B.1    Regan, M.M.2    Lykkesfeldt, A.E.3
  • 97
    • 0036187710 scopus 로고    scopus 로고
    • NH(2)-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer
    • Molina MA, Saez R, Ramsey EE et al. NH(2)-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer. Clin. Cancer Res. 8(2), 347-353 (2002).
    • (2002) Clin. Cancer Res , vol.8 , Issue.2 , pp. 347-353
    • Molina, M.A.1    Saez, R.2    Ramsey, E.E.3
  • 98
    • 0026071364 scopus 로고
    • The extracellular domain of pl85/neu is released from the surface of human breast carcinoma cells, SK-BR-3
    • Zabrecky JR, Lam T, McKenzie SJ, Carney W. The extracellular domain of pl85/neu is released from the surface of human breast carcinoma cells, SK-BR-3. J. Biol. Chem. 266(3), 1716-1720 (1991).
    • (1991) J. Biol. Chem , vol.266 , Issue.3 , pp. 1716-1720
    • Zabrecky, J.R.1    Lam, T.2    McKenzie, S.J.3    Carney, W.4
  • 99
    • 14644401104 scopus 로고    scopus 로고
    • Serum HER2 extracellular domain in metastatic breast cancer patients treated with weekly trastuzumab and paclitaxel: Association with HER2 status by immunohistochemistry and fluorescence in situ hybridization and with response rate
    • Fornier MN, Seidman AD, Schwartz MK et al. Serum HER2 extracellular domain in metastatic breast cancer patients treated with weekly trastuzumab and paclitaxel: association with HER2 status by immunohistochemistry and fluorescence in situ hybridization and with response rate. Ann. Oncol. 16(2), 234-239 (2005).
    • (2005) Ann. Oncol , vol.16 , Issue.2 , pp. 234-239
    • Fornier, M.N.1    Seidman, A.D.2    Schwartz, M.K.3
  • 100
    • 2442591882 scopus 로고    scopus 로고
    • Serum levels of HER2 ECD can determine the response rate to low dose oral cyclophosphamide and methotrexate in patients with advanced stage breast carcinoma, 242C, 1261-1266
    • Sandri MT, Johansson H, Colleoni M et al. Serum levels of HER2 ECD can determine the response rate to low dose oral cyclophosphamide and methotrexate in patients with advanced stage breast carcinoma. Anticancer Res. 24(2C), 1261-1266 (2004).
    • (2004) Anticancer Res
    • Sandri, M.T.1    Johansson, H.2    Colleoni, M.3
  • 101
    • 33646157497 scopus 로고    scopus 로고
    • Ductal carcinoma in situ with basal-like phenotype: A possible precursor to invasive basal-like breast cancer
    • Bryan BB, Schnitt SJ, Collins LC. Ductal carcinoma in situ with basal-like phenotype: a possible precursor to invasive basal-like breast cancer. Mod. Pathol. 19(5), 617-621 (2006).
    • (2006) Mod. Pathol , vol.19 , Issue.5 , pp. 617-621
    • Bryan, B.B.1    Schnitt, S.J.2    Collins, L.C.3
  • 102
    • 33847663351 scopus 로고    scopus 로고
    • P-cadherin and cytokeratin 5: Useful adjunct markers to distinguish basal-like ductal carcinomas in situ
    • Paredes J, Lopes N, Milanezi F, Schmitt FC. P-cadherin and cytokeratin 5: useful adjunct markers to distinguish basal-like ductal carcinomas in situ. Virchows Arch. 450(1), 73-80 (2007).
    • (2007) Virchows Arch , vol.450 , Issue.1 , pp. 73-80
    • Paredes, J.1    Lopes, N.2    Milanezi, F.3    Schmitt, F.C.4
  • 103
    • 33846197980 scopus 로고    scopus 로고
    • Identification of a basal-like subtype of breast ductal carcinoma in situ
    • Livasy CA, Perou CM, Karaca G et al. Identification of a basal-like subtype of breast ductal carcinoma in situ. Hum. Pathol. 38(2), 197-204 (2007).
    • (2007) Hum. Pathol , vol.38 , Issue.2 , pp. 197-204
    • Livasy, C.A.1    Perou, C.M.2    Karaca, G.3
  • 104
    • 33847339743 scopus 로고    scopus 로고
    • A mouse model of basal-like breast carcinoma with metaplastic elements
    • McCarthy A, Savage K, Gabriel A et al. A mouse model of basal-like breast carcinoma with metaplastic elements. J. Pathol. 211 (4), 389-398 (2007).
    • (2007) J. Pathol , vol.211 , Issue.4 , pp. 389-398
    • McCarthy, A.1    Savage, K.2    Gabriel, A.3
  • 105
    • 33646428682 scopus 로고    scopus 로고
    • The basal phenotype of BRCAl-related breast cancer: Past, present and future
    • Tischkowitz MD, Foulkes WD. The basal phenotype of BRCAl-related breast cancer: past, present and future. Cell Cycle 5(9), 963-967 (2006).
    • (2006) Cell Cycle , vol.5 , Issue.9 , pp. 963-967
    • Tischkowitz, M.D.1    Foulkes, W.D.2
  • 106
    • 33847035558 scopus 로고    scopus 로고
    • James CR, Quinn JE, Mullan PB, Johnston Harkin DP. BRCAl, a potential predictive biomarker in the treatment of breast cancer. Oncologist 12(2), 142-150(2007).
    • James CR, Quinn JE, Mullan PB, Johnston PG, Harkin DP. BRCAl, a potential predictive biomarker in the treatment of breast cancer. Oncologist 12(2), 142-150(2007).
  • 107
    • 0026571910 scopus 로고
    • The clinical significance of epidermal growth factor receptor (EGF-R) in human breast cancer: A review on 5232 patients
    • Klijn JG, Berns PM, Schmitz PI, Foekens JA. The clinical significance of epidermal growth factor receptor (EGF-R) in human breast cancer: a review on 5232 patients. Endocr. Rev. 13(1), 3-17 (1992).
    • (1992) Endocr. Rev , vol.13 , Issue.1 , pp. 3-17
    • Klijn, J.G.1    Berns, P.M.2    Schmitz, P.I.3    Foekens, J.A.4
  • 108
    • 24044520039 scopus 로고    scopus 로고
    • EGFR gene amplification in breast cancer: Correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations
    • Bhargava R, Gerald WL, Li AR et al. EGFR gene amplification in breast cancer: correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations. Mod. Pathol. 18(8), 1027-1033(2005).
    • (2005) Mod. Pathol , vol.18 , Issue.8 , pp. 1027-1033
    • Bhargava, R.1    Gerald, W.L.2    Li, A.R.3
  • 109
    • 38849208351 scopus 로고    scopus 로고
    • Independent prognostic value of the basal-like phenotype of breast cancer and associations with EGFR and candidate stem cell marker BMI-1
    • Arnes JB, Collett K, Akslen LA. Independent prognostic value of the basal-like phenotype of breast cancer and associations with EGFR and candidate stem cell marker BMI-1. Histopathology 52(3), 370-380 (2008).
    • (2008) Histopathology , vol.52 , Issue.3 , pp. 370-380
    • Arnes, J.B.1    Collett, K.2    Akslen, L.A.3
  • 110
    • 23444460828 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression correlates with poor survival in patients who have breast carcinoma treated with doxorubicin-based neoadjuvant chemotherapy
    • Buchholz TA, Tu X, Ang KK et al. Epidermal growth factor receptor expression correlates with poor survival in patients who have breast carcinoma treated with doxorubicin-based neoadjuvant chemotherapy. Cancer 104(4), 676-681 (2005).
    • (2005) Cancer , vol.104 , Issue.4 , pp. 676-681
    • Buchholz, T.A.1    Tu, X.2    Ang, K.K.3
  • 111
    • 40949121882 scopus 로고    scopus 로고
    • Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype
    • Cheang MC, Voduc D, Bajdik C et al. Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype. Clin. Cancer Res. 14(5), 1368-1376 (2008).
    • (2008) Clin. Cancer Res , vol.14 , Issue.5 , pp. 1368-1376
    • Cheang, M.C.1    Voduc, D.2    Bajdik, C.3
  • 112
    • 24644445676 scopus 로고    scopus 로고
    • Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients
    • Cappuzzo F, Varella-Garcia M, Shigematsu H et al. Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients. J. Clin. Oncol. 23(22), 5007-5018 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.22 , pp. 5007-5018
    • Cappuzzo, F.1    Varella-Garcia, M.2    Shigematsu, H.3
  • 113
    • 20444498630 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer
    • Cappuzzo F, Hirsch FR, Rossi E et al. Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J. Natl Cancer Inst. 97(9), 643-655 (2005).
    • (2005) J. Natl Cancer Inst , vol.97 , Issue.9 , pp. 643-655
    • Cappuzzo, F.1    Hirsch, F.R.2    Rossi, E.3
  • 114
    • 0142119289 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis
    • Hirsch FR, Varella-Garcia M, Bunn PA Jr et al. Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis. J. Clin. Oncol. 21(20), 3798-3807 (2003).
    • (2003) J. Clin. Oncol , vol.21 , Issue.20 , pp. 3798-3807
    • Hirsch, F.R.1    Varella-Garcia, M.2    Bunn Jr, P.A.3
  • 115
    • 36649030622 scopus 로고    scopus 로고
    • Expression and amplification of Her2, EGFR and cyclin Dl in breast cancer: Immunohistochemistry and chromogenic in situ hybridization
    • Cho EY, Choi YL, Han JJ, Kim KM, Oh YL. Expression and amplification of Her2, EGFR and cyclin Dl in breast cancer: immunohistochemistry and chromogenic in situ hybridization. Pathol. Int. 58(1), 17-25 (2008).
    • (2008) Pathol. Int , vol.58 , Issue.1 , pp. 17-25
    • Cho, E.Y.1    Choi, Y.L.2    Han, J.J.3    Kim, K.M.4    Oh, Y.L.5
  • 116
    • 44149098849 scopus 로고    scopus 로고
    • Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients
    • Sassen A, Rochon J, Wild P et al. Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients. Breast Cancer Res. 10(1), R2 (2008).
    • (2008) Breast Cancer Res , vol.10 , Issue.1
    • Sassen, A.1    Rochon, J.2    Wild, P.3
  • 117
    • 33847323129 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in lung cancer
    • Sharma SV, Bell DW, Settleman J, Haber DA. Epidermal growth factor receptor mutations in lung cancer. Nat. Rev. Cancer 7(3), 169-181 (2007).
    • (2007) Nat. Rev. Cancer , vol.7 , Issue.3 , pp. 169-181
    • Sharma, S.V.1    Bell, D.W.2    Settleman, J.3    Haber, D.A.4
  • 118
    • 33748134662 scopus 로고    scopus 로고
    • The role of the epidermal growth factor receptor in breast cancer
    • Chan SK, Hill ME, Gullick WJ. The role of the epidermal growth factor receptor in breast cancer. J. Mammary Gland Biol. Neoplasia 11(1), 3-11 (2006).
    • (2006) J. Mammary Gland Biol. Neoplasia , vol.11 , Issue.1 , pp. 3-11
    • Chan, S.K.1    Hill, M.E.2    Gullick, W.J.3
  • 119
    • 33745986327 scopus 로고    scopus 로고
    • HER2 testing by local, central, and reference laboratories in specimens from the North Central Cancer Treatment Group N9831 intergroup adjuvant trial
    • Perez EA, Suman VJ, Davidson NE et al. HER2 testing by local, central, and reference laboratories in specimens from the North Central Cancer Treatment Group N9831 intergroup adjuvant trial. J. Clin. Oncol. 24(19), 3032-3038 (2006).
    • (2006) J. Clin. Oncol , vol.24 , Issue.19 , pp. 3032-3038
    • Perez, E.A.1    Suman, V.J.2    Davidson, N.E.3
  • 120
    • 34447302567 scopus 로고    scopus 로고
    • External quality assurance of HER2 fluorescence in situ hybridisation testing: Results of a UK NEQAS pilot scheme
    • Bartlett JM, Ibrahim M, Jasani B et al. External quality assurance of HER2 fluorescence in situ hybridisation testing: results of a UK NEQAS pilot scheme. J. Clin. Pathol. 60(7), 816-819 (2007).
    • (2007) J. Clin. Pathol , vol.60 , Issue.7 , pp. 816-819
    • Bartlett, J.M.1    Ibrahim, M.2    Jasani, B.3
  • 121
    • 1542503725 scopus 로고    scopus 로고
    • HER-2 testing and trastuzumab therapy for metastatic breast cancer: A cost-effectiveness analysis
    • Elkin EB, Weinstein MC, Winer EP et al. HER-2 testing and trastuzumab therapy for metastatic breast cancer: a cost-effectiveness analysis. J. Clin. Oncol. 22(5), 854-863 (2004).
    • (2004) J. Clin. Oncol , vol.22 , Issue.5 , pp. 854-863
    • Elkin, E.B.1    Weinstein, M.C.2    Winer, E.P.3
  • 122
    • 36849043530 scopus 로고    scopus 로고
    • Quantitative justification of the change from 10% to 30% for human epidermal growth factor receptor 2 scoring in the American Society of Clinical Oncology/College of American Pathologists guidelines: Tumor heterogeneity in breast cancer and its implications for tissue microarray based assessment of outcome
    • Moeder CB, Giltnane JM, Harigopal M et al. Quantitative justification of the change from 10% to 30% for human epidermal growth factor receptor 2 scoring in the American Society of Clinical Oncology/College of American Pathologists guidelines: tumor heterogeneity in breast cancer and its implications for tissue microarray based assessment of outcome. J. Clin. Oncol. 25(34), 5418-5425 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.34 , pp. 5418-5425
    • Moeder, C.B.1    Giltnane, J.M.2    Harigopal, M.3
  • 123
    • 0347539778 scopus 로고    scopus 로고
    • Calibration of immunohistochemistry for assessment of HER2 in breast cancer: Results of the French multicentre GEFPICS study
    • Vincent-Salomon A, MacGrogan G, Couturier J et al. Calibration of immunohistochemistry for assessment of HER2 in breast cancer: results of the French multicentre GEFPICS study. Histopathology 42(4), 337-347 (2003).
    • (2003) Histopathology , vol.42 , Issue.4 , pp. 337-347
    • Vincent-Salomon, A.1    MacGrogan, G.2    Couturier, J.3
  • 124
    • 26844498595 scopus 로고    scopus 로고
    • Phosphorylated/activated HER2 as a marker of clinical resistance to single agent taxane chemotherapy for metastatic breast cancer
    • Modi S, DiGiovanna MP, Lu Z et al. Phosphorylated/activated HER2 as a marker of clinical resistance to single agent taxane chemotherapy for metastatic breast cancer. Cancer Invest. 23(6), 483-487 (2005).
    • (2005) Cancer Invest , vol.23 , Issue.6 , pp. 483-487
    • Modi, S.1    DiGiovanna, M.P.2    Lu, Z.3
  • 125
    • 34548843012 scopus 로고    scopus 로고
    • HER2 evaluation using the novel rabbit monoclonal antibody SP3 and CISH in tissue microarrays of invasive breast carcinomas
    • Ricardo SA, Milanezi F, Carvalho ST, Leitao DR, Schmitt FC. HER2 evaluation using the novel rabbit monoclonal antibody SP3 and CISH in tissue microarrays of invasive breast carcinomas. J. Clin. Pathol. 60(9), 1001-1005 (2007).
    • (2007) J. Clin. Pathol , vol.60 , Issue.9 , pp. 1001-1005
    • Ricardo, S.A.1    Milanezi, F.2    Carvalho, S.T.3    Leitao, D.R.4    Schmitt, F.C.5
  • 126
    • 18044392064 scopus 로고    scopus 로고
    • A modified trastuzumab antibody for the immunohistochemical detection of HER-2 overexpression in breast cancer
    • Bussolati G, Montemurro F, Righi L et al. A modified trastuzumab antibody for the immunohistochemical detection of HER-2 overexpression in breast cancer. Br. J. Cancer 92(7), 1261-1267 (2005).
    • (2005) Br. J. Cancer , vol.92 , Issue.7 , pp. 1261-1267
    • Bussolati, G.1    Montemurro, F.2    Righi, L.3
  • 127
    • 37349046484 scopus 로고    scopus 로고
    • Patients with advanced stage breast carcinoma immunoreactive to biotinylated Herceptin are most likely to benefit from trastuzumab-based therapy: An hypothesis-generating study
    • Sapino A, Montemurro F, Marchio C et al. Patients with advanced stage breast carcinoma immunoreactive to biotinylated Herceptin are most likely to benefit from trastuzumab-based therapy: an hypothesis-generating study. Ann. Oncol. 18(12), 1963-1968 (2007).
    • (2007) Ann. Oncol , vol.18 , Issue.12 , pp. 1963-1968
    • Sapino, A.1    Montemurro, F.2    Marchio, C.3
  • 128
    • 0035874981 scopus 로고    scopus 로고
    • Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells
    • Molina MA, Codony-Servat J, Albanell J et al. Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells. Cancer Res. 61(12), 4744-4749 (2001).
    • (2001) Cancer Res , vol.61 , Issue.12 , pp. 4744-4749
    • Molina, M.A.1    Codony-Servat, J.2    Albanell, J.3
  • 129
    • 33745765680 scopus 로고    scopus 로고
    • Identification of ADAM 10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells
    • Liu PC, Liu X, Li Y et al. Identification of ADAM 10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells. Cancer Biol. Ther. 5(6), 657-664 (2006).
    • (2006) Cancer Biol. Ther , vol.5 , Issue.6 , pp. 657-664
    • Liu, P.C.1    Liu, X.2    Li, Y.3
  • 130
    • 33644528230 scopus 로고    scopus 로고
    • Clinical utility of serum HER2/neu in monitoring and prediction of progression-free survival in metastatic breast cancer patients treated with trastuzumab-based therapies
    • Esteva FJ, Cheli CD, Fritsche H et al. Clinical utility of serum HER2/neu in monitoring and prediction of progression-free survival in metastatic breast cancer patients treated with trastuzumab-based therapies. Breast Cancer Res. 7(4), R436-R443 (2005).
    • (2005) Breast Cancer Res , vol.7 , Issue.4
    • Esteva, F.J.1    Cheli, C.D.2    Fritsche, H.3
  • 131
    • 33745877913 scopus 로고    scopus 로고
    • Concordance between central and local laboratory HER2 testing from a community-based clinical study
    • Reddy JC, Reimann JD, Anderson SM, Klein PM. Concordance between central and local laboratory HER2 testing from a community-based clinical study. Clin. Breast Cancer 7(2), 153-157 (2006).
    • (2006) Clin. Breast Cancer , vol.7 , Issue.2 , pp. 153-157
    • Reddy, J.C.1    Reimann, J.D.2    Anderson, S.M.3    Klein, P.M.4
  • 132
    • 38049055410 scopus 로고    scopus 로고
    • HER2 testing in a population-based study of patients with metastatic breast cancer treated with trastuzumab
    • O'Malley FP, Thomson T, Julian J et al. HER2 testing in a population-based study of patients with metastatic breast cancer treated with trastuzumab. Arch. Pathol. lab. Med. 132(1), 61-65 (2008).
    • (2008) Arch. Pathol. lab. Med , vol.132 , Issue.1 , pp. 61-65
    • O'Malley, F.P.1    Thomson, T.2    Julian, J.3
  • 133
    • 33747622311 scopus 로고    scopus 로고
    • HER2 testing in breast cancer: NCCN Task Force report and recommendations
    • quiz S23-S24
    • Carlson RW, Moench SJ, Hammond ME et al. HER2 testing in breast cancer: NCCN Task Force report and recommendations. J. Natl Compr. Canc. Netw. 4(Suppl. 3), S1-S22; quiz S23-S24 (2006).
    • (2006) J. Natl Compr. Canc. Netw , vol.4 , Issue.SUPPL. 3
    • Carlson, R.W.1    Moench, S.J.2    Hammond, M.E.3
  • 134
    • 36649015630 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization (FISH) as primary methodology for the assessment of HER2 status in adenocarcinoma of the breast: A single institution experience
    • Tubbs RR, Hicks DG, Cook J et al. Fluorescence in situ hybridization (FISH) as primary methodology for the assessment of HER2 status in adenocarcinoma of the breast: a single institution experience. Diagn. Mol Pathol. 16(4), 207-210 (2007).
    • (2007) Diagn. Mol Pathol , vol.16 , Issue.4 , pp. 207-210
    • Tubbs, R.R.1    Hicks, D.G.2    Cook, J.3
  • 135
    • 20444457037 scopus 로고    scopus 로고
    • Polysomy 17 in HER-2/neu status elaboration in breast cancer: Effect on daily practice
    • Ma Y, Lespagnard L, Durbecq V, Paesmans M et al. Polysomy 17 in HER-2/neu status elaboration in breast cancer: effect on daily practice. Clin. Cancer Res. 11(12), 4393-4399 (2005).
    • (2005) Clin. Cancer Res , vol.11 , Issue.12 , pp. 4393-4399
    • Ma, Y.1    Lespagnard, L.2    Durbecq, V.3    Paesmans, M.4
  • 136
    • 33745153139 scopus 로고    scopus 로고
    • Analysis of aneusomy level and HER-2 gene copy number and their effect on amplification rate in breast cancer specimens read as 2+ in immunohistochemical analysis
    • Merola R, Mottolese M, Orlandi G et al. Analysis of aneusomy level and HER-2 gene copy number and their effect on amplification rate in breast cancer specimens read as 2+ in immunohistochemical analysis. Eur. J. Cancer 42(10), 1501-1506 (2006).
    • (2006) Eur. J. Cancer , vol.42 , Issue.10 , pp. 1501-1506
    • Merola, R.1    Mottolese, M.2    Orlandi, G.3
  • 137
    • 33747883996 scopus 로고    scopus 로고
    • Dual-colour chromogenic in situ hybridization for testing of HER-2 oncogene amplification in archival breast tumours
    • Laakso M, Tanner M, Isola J. Dual-colour chromogenic in situ hybridization for testing of HER-2 oncogene amplification in archival breast tumours. J. Pathol. 210(1), 3-9 (2006).
    • (2006) J. Pathol , vol.210 , Issue.1 , pp. 3-9
    • Laakso, M.1    Tanner, M.2    Isola, J.3
  • 138
    • 28044458147 scopus 로고    scopus 로고
    • Role of chromogenic in situ hybridization (CISH) in the evaluation of HER2 status in breast carcinoma: Comparison with immunohistochemistry and FISH
    • Li-Ning TE, Ronchetti R, Torres-Cabala C, Merino MJ. Role of chromogenic in situ hybridization (CISH) in the evaluation of HER2 status in breast carcinoma: comparison with immunohistochemistry and FISH. Int. J. Surg. Pathol. 13(4), 343-351 (2005).
    • (2005) Int. J. Surg. Pathol , vol.13 , Issue.4 , pp. 343-351
    • Li-Ning, T.E.1    Ronchetti, R.2    Torres-Cabala, C.3    Merino, M.J.4
  • 139
    • 34447295638 scopus 로고    scopus 로고
    • Chromogenic and fluorescent in situ hybridization in breast cancer
    • Lambros MB, Natrajan R, Reis-Filho JS. Chromogenic and fluorescent in situ hybridization in breast cancer. Hum. Pathol. 38(8), 1105-1122(2007).
    • (2007) Hum. Pathol , vol.38 , Issue.8 , pp. 1105-1122
    • Lambros, M.B.1    Natrajan, R.2    Reis-Filho, J.S.3
  • 140
    • 35748985896 scopus 로고    scopus 로고
    • Comparison of automated silver enhanced in situ hybridisation (SISH) and fluorescence ISH (FISH) for the validation of HER2 gene status in breast carcinoma according to the guidelines of the American Society of Clinical Oncology and the College of American Pathologists
    • Dietel M, Ellis IO, Hofler H et al. Comparison of automated silver enhanced in situ hybridisation (SISH) and fluorescence ISH (FISH) for the validation of HER2 gene status in breast carcinoma according to the guidelines of the American Society of Clinical Oncology and the College of American Pathologists. Virchows Arch. 451(1), 19-25 (2007).
    • (2007) Virchows Arch , vol.451 , Issue.1 , pp. 19-25
    • Dietel, M.1    Ellis, I.O.2    Hofler, H.3
  • 141
    • 28444491796 scopus 로고    scopus 로고
    • Gefitinib (ZD1839) combined with weekly epirubicin in patients with metastatic breast cancer: A Phase I study with biological correlate
    • Gasparini G, Sarmiento R, Amici S et al. Gefitinib (ZD1839) combined with weekly epirubicin in patients with metastatic breast cancer: a Phase I study with biological correlate. Ann. Oncol. 16(12), 1867-1873 (2005).
    • (2005) Ann. Oncol , vol.16 , Issue.12 , pp. 1867-1873
    • Gasparini, G.1    Sarmiento, R.2    Amici, S.3
  • 142
    • 19944408390 scopus 로고    scopus 로고
    • Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor-positive primary breast cancer: A double-blind placebo-controlled Phase II randomised trial
    • Polychronis A, Sinnett HD, Hadjiminas D et al. Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor-positive primary breast cancer: a double-blind placebo-controlled Phase II randomised trial. Lancet Oncol. 6(6), 383-391 (2005).
    • (2005) Lancet Oncol , vol.6 , Issue.6 , pp. 383-391
    • Polychronis, A.1    Sinnett, H.D.2    Hadjiminas, D.3
  • 143
    • 20844456577 scopus 로고    scopus 로고
    • A multicentre Phase II study on gefitinib in taxane- and anthracycline-pretreated metastatic breast cancer
    • von Minckwitz G, Jonat W, Fasching P et al. A multicentre Phase II study on gefitinib in taxane- and anthracycline-pretreated metastatic breast cancer. Breast Cancer Res. Treat. 89(2), 165-172 (2005).
    • (2005) Breast Cancer Res. Treat , vol.89 , Issue.2 , pp. 165-172
    • von Minckwitz, G.1    Jonat, W.2    Fasching, P.3
  • 144
    • 23944464495 scopus 로고    scopus 로고
    • Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer
    • Baselga J, Albanell J, Ruiz A et al. Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer. J. Clin. Oncol. 23(23), 5323-5333 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.23 , pp. 5323-5333
    • Baselga, J.1    Albanell, J.2    Ruiz, A.3
  • 145
    • 35548961447 scopus 로고    scopus 로고
    • A mechanistic perspective of monoclonal antibodies in cancer therapy beyond target-related effects
    • Strome SE, Sausville EA, Mann D. A mechanistic perspective of monoclonal antibodies in cancer therapy beyond target-related effects. Oncologist 12(9), 1084-1095 (2007).
    • (2007) Oncologist , vol.12 , Issue.9 , pp. 1084-1095
    • Strome, S.E.1    Sausville, E.A.2    Mann, D.3
  • 146
    • 34547697317 scopus 로고    scopus 로고
    • Antibodies to the epidermal growth factor receptor in non small cell lung cancer: Current status of matuzumab and panitumumab
    • Socinski MA. Antibodies to the epidermal growth factor receptor in non small cell lung cancer: current status of matuzumab and panitumumab. Clin. Cancer Res. 13(15 Pt 2), S4597-S4601 (2007).
    • (2007) Clin. Cancer Res , vol.13 , Issue.15 PART 2
    • Socinski, M.A.1
  • 147
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256(5517), 495-497(1975).
    • (1975) Nature , vol.256 , Issue.5517 , pp. 495-497
    • Kohler, G.1    Milstein, C.2
  • 148
    • 35948977282 scopus 로고    scopus 로고
    • Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies
    • Yu Z, Boggon TJ, Kobayashi S et al. Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies. Cancer Res. 67(21), 10417-10427(2007).
    • (2007) Cancer Res , vol.67 , Issue.21 , pp. 10417-10427
    • Yu, Z.1    Boggon, T.J.2    Kobayashi, S.3
  • 149
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond EH, Perez EA, Bryant J et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N. Engl. J. Med. 353(16), 1673-1684 (2005).
    • (2005) N. Engl. J. Med , vol.353 , Issue.16 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3
  • 150
    • 33748525213 scopus 로고    scopus 로고
    • Adjuvant therapy with trastuzumab for HER-2/neu-positive breast cancer
    • Gonzalez-Angulo AM, Hortobagyi GN, Esteva FJ. Adjuvant therapy with trastuzumab for HER-2/neu-positive breast cancer. Oncologist 11(8), 857-867 (2006).
    • (2006) Oncologist , vol.11 , Issue.8 , pp. 857-867
    • Gonzalez-Angulo, A.M.1    Hortobagyi, G.N.2    Esteva, F.J.3
  • 151
    • 31644439702 scopus 로고    scopus 로고
    • Herceptin: Mechanisms of action and resistance
    • Nahta R, Esteva FJ. Herceptin: mechanisms of action and resistance. Cancer Lett. 232(2), 123-138 (2006).
    • (2006) Cancer Lett , vol.232 , Issue.2 , pp. 123-138
    • Nahta, R.1    Esteva, F.J.2
  • 152
    • 33749011681 scopus 로고    scopus 로고
    • A Phase I study of cetuximab/paclitaxel in patients with advanced-stage breast cancer
    • Modi S, D'Andrea G, Norton L et al. A Phase I study of cetuximab/paclitaxel in patients with advanced-stage breast cancer. Clin. Breast Cancer 7(3), 270-277 (2006).
    • (2006) Clin. Breast Cancer , vol.7 , Issue.3 , pp. 270-277
    • Modi, S.1    D'Andrea, G.2    Norton, L.3
  • 153
    • 34547096751 scopus 로고    scopus 로고
    • Breast cancer expressing the activated HER2/neu is sensitive to gefitinib in vitro and in vivo and acquires resistance through a novel point mutation in the HER2/neu
    • Piechocki MP, Yoo GH, Dibbley SK, Lonardo F Breast cancer expressing the activated HER2/neu is sensitive to gefitinib in vitro and in vivo and acquires resistance through a novel point mutation in the HER2/neu. Cancer Res. 67(14), 6825-6843 (2007).
    • (2007) Cancer Res , vol.67 , Issue.14 , pp. 6825-6843
    • Piechocki, M.P.1    Yoo, G.H.2    Dibbley, S.K.3    Lonardo, F.4
  • 154
    • 52949127301 scopus 로고    scopus 로고
    • Breast cancer cells with acquired resistance to the EGFR tyrosine kinase inhibitor gefitinib show persistent activation of MAPK signaling
    • Epub ahead of print
    • Normanno N, Campiglio M, Maiello MR et al. Breast cancer cells with acquired resistance to the EGFR tyrosine kinase inhibitor gefitinib show persistent activation of MAPK signaling. Breast Cancer Res. Treat. (2007) (Epub ahead of print).
    • (2007) Breast Cancer Res. Treat
    • Normanno, N.1    Campiglio, M.2    Maiello, M.R.3
  • 156
    • 35248889408 scopus 로고    scopus 로고
    • EGFR associated expression profiles vary with breast tumor subtype
    • Hoadley KA, Weigman VJ, Fan C et al. EGFR associated expression profiles vary with breast tumor subtype. BMC Genomics 8, 258 (2007).
    • (2007) BMC Genomics , vol.8 , pp. 258
    • Hoadley, K.A.1    Weigman, V.J.2    Fan, C.3
  • 157
    • 39749085432 scopus 로고    scopus 로고
    • Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancers
    • Guix M, Granja Nde M, Meszoely I et al. Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancers. J. Clin. Oncol. 26(6), 897-906 (2008).
    • (2008) J. Clin. Oncol , vol.26 , Issue.6 , pp. 897-906
    • Guix, M.1    Granja Nde, M.2    Meszoely, I.3
  • 158
    • 33751344602 scopus 로고    scopus 로고
    • HER2 therapy: Molecular mechanisms of trastuzumab resistance
    • Nahta R, Esteva FJ. HER2 therapy: molecular mechanisms of trastuzumab resistance. Breast Cancer Res. 8 (6), 215 (2006).
    • (2006) Breast Cancer Res , vol.8 , Issue.6 , pp. 215
    • Nahta, R.1    Esteva, F.J.2
  • 159
    • 32244435355 scopus 로고    scopus 로고
    • Mechanisms of trastuzumab resistance and their clinical implications
    • Lan KH, Lu CH, Yu D. Mechanisms of trastuzumab resistance and their clinical implications. Ann. NY Acad. Sci. 1059, 70-75 (2005).
    • (2005) Ann. NY Acad. Sci , vol.1059 , pp. 70-75
    • Lan, K.H.1    Lu, C.H.2    Yu, D.3
  • 160
    • 12544250996 scopus 로고    scopus 로고
    • Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line
    • Nagy P, Friedlander E, Tanner M et al. Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line. Cancer Res. 65(2), 473-482 (2005).
    • (2005) Cancer Res , vol.65 , Issue.2 , pp. 473-482
    • Nagy, P.1    Friedlander, E.2    Tanner, M.3
  • 161
    • 34247588567 scopus 로고    scopus 로고
    • Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer
    • Scaltriti M, Rojo F, Ocana A et al. Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. J. Natl Cancer Inst. 99(8), 628-638 (2007)
    • (2007) J. Natl Cancer Inst , vol.99 , Issue.8 , pp. 628-638
    • Scaltriti, M.1    Rojo, F.2    Ocana, A.3
  • 162
    • 43049106865 scopus 로고    scopus 로고
    • Evaluation of serum HER2 extracellular domain in early breast cancer patients: Correlation with clinicopathological parameters and survival
    • Ludovini V, Gori S, Colozza M et al. Evaluation of serum HER2 extracellular domain in early breast cancer patients: correlation with clinicopathological parameters and survival. Ann. Oncol. 19(5), 883-890 (2008).
    • (2008) Ann. Oncol , vol.19 , Issue.5 , pp. 883-890
    • Ludovini, V.1    Gori, S.2    Colozza, M.3
  • 163
    • 5144226211 scopus 로고    scopus 로고
    • PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
    • Nagata Y, Lan KH, Zhou X et al. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 6(2), 117-127(2004).
    • (2004) Cancer Cell , vol.6 , Issue.2 , pp. 117-127
    • Nagata, Y.1    Lan, K.H.2    Zhou, X.3
  • 164
    • 31444444131 scopus 로고    scopus 로고
    • PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer
    • Fujita T, Doihara H, Kawasaki K et al. PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer. Br. J. Cancer 94(2), 247-252 (2006).
    • (2006) Br. J. Cancer , vol.94 , Issue.2 , pp. 247-252
    • Fujita, T.1    Doihara, H.2    Kawasaki, K.3
  • 165
    • 13844317894 scopus 로고    scopus 로고
    • EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
    • Kobayashi S, Boggon TJ, Dayaram T et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 352(8), 786-792 (2005).
    • (2005) N. Engl. J. Med , vol.352 , Issue.8 , pp. 786-792
    • Kobayashi, S.1    Boggon, T.J.2    Dayaram, T.3
  • 166
    • 33846566408 scopus 로고    scopus 로고
    • Dual inhibition of ErbBl (EGFR/HER1) and ErbB2 (HER2/neu)
    • Reid A, Vidal L, Shaw H, de Bono J. Dual inhibition of ErbBl (EGFR/HER1) and ErbB2 (HER2/neu). Eur. J. Cancer 43(3), 481-489 (2007).
    • (2007) Eur. J. Cancer , vol.43 , Issue.3 , pp. 481-489
    • Reid, A.1    Vidal, L.2    Shaw, H.3    de Bono, J.4
  • 167
    • 20244388653 scopus 로고    scopus 로고
    • Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB 1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies
    • Spector NL, Xia W, Burris H III et al. Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB 1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies. J. Clin. Oncol. 23(11), 2502-2512 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.11 , pp. 2502-2512
    • Spector, N.L.1    Xia, W.2    Burris III, H.3
  • 168
    • 32944461545 scopus 로고    scopus 로고
    • Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells
    • Konecny GE, Pegram MD, Venkatesan N et al. Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells. Cancer Res. 66(3), 1630-1639 (2006).
    • (2006) Cancer Res , vol.66 , Issue.3 , pp. 1630-1639
    • Konecny, G.E.1    Pegram, M.D.2    Venkatesan, N.3
  • 169
    • 34548433016 scopus 로고    scopus 로고
    • Clinical strategies for rationale combinations of aromatase inhibitors with novel therapies for breast cancer
    • Johnston SR, Martin LA, Leary A, Head J, Dowsett M. Clinical strategies for rationale combinations of aromatase inhibitors with novel therapies for breast cancer. J. Steroid Biochem. Mol Biol. 106(1-5), 180-186 (2007).
    • (2007) J. Steroid Biochem. Mol Biol , vol.106 , Issue.1-5 , pp. 180-186
    • Johnston, S.R.1    Martin, L.A.2    Leary, A.3    Head, J.4    Dowsett, M.5
  • 170
    • 35748937088 scopus 로고    scopus 로고
    • Lapatinib in breast cancer
    • Bilancia D, Rosati G, Dinota A et al. Lapatinib in breast cancer. Ann. Oncol. (18 Suppl. 6), vi26-vi30 (2007).
    • (2007) Ann. Oncol , vol.18 , Issue.SUPPL. 6
    • Bilancia, D.1    Rosati, G.2    Dinota, A.3
  • 171
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • Geyer CE, Forster J, Lindquist D et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N. Engl J. Med. 355(26), 2733-2743 (2006).
    • (2006) N. Engl J. Med , vol.355 , Issue.26 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 172
    • 1942474587 scopus 로고    scopus 로고
    • The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells
    • Nahta R, Hung MC, Esteva FJ. The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells. Cancer Res. 64(7), 2343-2346 (2004).
    • (2004) Cancer Res , vol.64 , Issue.7 , pp. 2343-2346
    • Nahta, R.1    Hung, M.C.2    Esteva, F.J.3
  • 173
    • 35748935901 scopus 로고    scopus 로고
    • Carteni G, Fiorentino R, Vecchione L, Chiurazzi B, Battista C. Panitumumab a novel drug in cancer treatment. Ann. Oncol. (18 Suppl. 6), vil6-vi21 (2007).
    • Carteni G, Fiorentino R, Vecchione L, Chiurazzi B, Battista C. Panitumumab a novel drug in cancer treatment. Ann. Oncol. (18 Suppl. 6), vil6-vi21 (2007).


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